Page last updated: 2024-08-17

quinidine and loperamide

quinidine has been researched along with loperamide in 29 studies

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.45)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (44.83)	29.6817
2010's	14 (48.28)	24.3611
2020's	1 (3.45)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Adachi, Y; Sugiyama, Y; Suzuki, H	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Brincat, JP; Broccatelli, F; Carosati, E; Cruciani, G; Frosini, M; Kaatz, GW; Neri, A; Sabatini, S	1
Gunaydin, H; Sun, Y; Weiss, MM	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
He, H; Sadeque, AJ; Shah, S; Wandel, C; Wood, AJ	1
Geisslinger, G; Jarrar, M; Kauert, G; Langer, M; Lötsch, J; Schmidt, H; Skarke, C	1
Dagenais, C; Graff, CL; Pollack, GM	1
Aldinger, T; Ayrton, A; Bentz, J; Ellens, H; Mittal, A; Polli, JW; Tran, TT	1
Ayrton, A; Bentz, J; Ellens, H; Polli, JW; Tran, TT	1
Acharya, P; Ayrton, A; Bentz, J; Ellens, H; Polli, JW; Tran, TT	1
Acharya, P; Ayrton, A; Bentz, J; Ellens, H; O'Connor, MP; Polli, JW	1
Kawabata, T; Kitamura, Y; Koto, H; Kusuhara, H; Matsuura, S; Sugiyama, Y; Tsuchiya, H; Tsujimoto, H	1
Pollack, GM; Zhao, R	1
Mealey, KL; Nelson, FR; Raunig, DL; Schmidt, KR; Waiting, D	1
Kataoka, M; Masaoka, Y; Sakuma, S; Yamashita, S; Yokoyama, T	1
Li, H; Shen, GL; Sun, HX; Yuan, M; Zhuang, XM	1
Ahmed, Z; Bentz, J; Ellens, H; Hidalgo, IJ; Li, J; Li, L; Lumen, AA; Meng, Z; Owen, A	1
Cho, JY; Han, H; Jang, IJ; Kim, TE; Lee, H; Lee, S; Lim, KS; Park, KM; Shin, SG; Yoon, SH; Yu, KS	1
Akazawa, T; Ohtsuki, S; Tachikawa, M; Terasaki, T; Uchida, Y	1
Bentz, J; Ellens, H; Meng, Z	1

Reviews

2 review(s) available for quinidine and loperamide

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

4 trial(s) available for quinidine and loperamide

Article	Year
Increased drug delivery to the brain by P-glycoprotein inhibition. Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:3 Topics: Adrenergic alpha-Antagonists; Adult; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Carbon Dioxide; Double-Blind Method; Drug Interactions; Humans; Loperamide; Male; Quinidine; Respiration	2000
Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. Pharmacogenetics, 2003, Volume: 13, Issue:11 Topics: Administration, Oral; Alleles; Base Sequence; Central Nervous System; Central Nervous System Agents; Double-Blind Method; Drug Interactions; Drug Resistance, Multiple; Genes, MDR; Genetic Variation; Haplotypes; Heterozygote; Humans; Loperamide; Miosis; Mutation; Narcotics; Pupil; Quinidine	2003
Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs. Journal of veterinary pharmacology and therapeutics, 2010, Volume: 33, Issue:5 Topics: Animals; Anti-Anxiety Agents; Antidiarrheals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cross-Over Studies; Cyclosporine; Diazepam; Dogs; Enzyme Inhibitors; Female; Genotype; HIV Protease Inhibitors; Loperamide; Male; Nelfinavir; Quinidine; Substrate Specificity	2010
Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers. British journal of clinical pharmacology, 2014, Volume: 78, Issue:3 Topics: Adult; Antidiarrheals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzopyrans; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Humans; Intestinal Mucosa; Isoquinolines; Loperamide; Male; Middle Aged; Pupil; Quinidine; Tetrazoles; Young Adult	2014

Other Studies

23 other study(ies) available for quinidine and loperamide

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharmaceutical research, 2001, Volume: 18, Issue:12 Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Hydrolysis; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Models, Biological; Pharmaceutical Preparations; Swine; Tissue Distribution; Transfection	2001
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Ligand Promiscuity between the Efflux Pumps Human P-Glycoprotein and S. aureus NorA. ACS medicinal chemistry letters, 2012, Mar-08, Volume: 3, Issue:3 Topics:	2012
De novo prediction of p-glycoprotein-mediated efflux liability for druglike compounds. ACS medicinal chemistry letters, 2013, Jan-10, Volume: 4, Issue:1 Topics:	2013
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Variable modulation of opioid brain uptake by P-glycoprotein in mice. Biochemical pharmacology, 2004, Jan-15, Volume: 67, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Benzomorphans; Biological Transport; Brain; Drug Interactions; Fentanyl; Loperamide; Meperidine; Methadone; Mice; Narcotics; Quinidine; Time Factors; Verapamil	2004
The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells. Biophysical journal, 2005, Volume: 88, Issue:1 Topics: Algorithms; Animals; Antibiotics, Antitubercular; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carbamates; Cell Line; Cell Membrane; Cytoplasm; Diffusion; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Furans; Kinetics; Liposomes; Loperamide; Models, Chemical; Protein Binding; Quinidine; Software; Sulfonamides; Time Factors; Xenobiotics	2005
The steady-state Michaelis-Menten analysis of P-glycoprotein mediated transport through a confluent cell monolayer cannot predict the correct Michaelis constant Km. Pharmaceutical research, 2005, Volume: 22, Issue:10 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carbamates; Cell Line; Cell Membrane Permeability; Computer Simulation; Dogs; Furans; Humans; Loperamide; Models, Biological; Pharmacokinetics; Quinidine; Reproducibility of Results; Sulfonamides; Tetrahydroisoquinolines	2005
P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites. Biochemistry, 2006, Dec-26, Volume: 45, Issue:51 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Biological Transport, Active; Carbamates; Cell Line; Cell Membrane Permeability; Dogs; Furans; Humans; Loperamide; Protein Binding; Quinidine; Signal Transduction; Substrate Specificity; Sulfonamides	2006
Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamates; Cell Line; Cell Membrane; Digoxin; Dogs; Furans; Kinetics; Loperamide; Quinidine; Sulfonamides	2008
Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:5 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Dogs; Female; Intestinal Absorption; Loperamide; Male; Mutation; Quinidine; Terfenadine	2008
Regional differences in capillary density, perfusion rate, and P-glycoprotein activity: a quantitative analysis of regional drug exposure in the brain. Biochemical pharmacology, 2009, Oct-15, Volume: 78, Issue:8 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Capillaries; Colchicine; Dose-Response Relationship, Drug; Infusions, Subcutaneous; Inulin; Least-Squares Analysis; Linear Models; Loperamide; Mice; Mice, Inbred Strains; Mice, Knockout; Microdissection; Perfusion; Quinidine; Regional Blood Flow; Substrate Specificity; Verapamil	2009
Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Nov-20, Volume: 44, Issue:4 Topics: Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Drug Interactions; Erythromycin; Gene Expression; Glycerol; Humans; Intestinal Absorption; Loperamide; Models, Biological; Pharmaceutical Preparations; Propanolamines; Puromycin; Quinidine; Saquinavir; Solubility; Surface-Active Agents; Terfenadine; Verapamil; Vinblastine	2011
[Evaluation of P-glycoprotein mediated in vitro loperamide biliary excretion with sandwich-cultured rat hepatocytes model]. Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:4 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclosporine; Hepatocytes; Loperamide; Male; Quinidine; Quinolines; Rats; Rats, Sprague-Dawley; Rhodamine 123; Tandem Mass Spectrometry	2012
Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp. PloS one, 2013, Volume: 8, Issue:8 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Carbamates; Cell Membrane Permeability; Cyclosporine; Digoxin; Dogs; Furans; Gene Expression; Humans; Ketoconazole; Kinetics; Loperamide; Madin Darby Canine Kidney Cells; Protein Binding; Quinidine; Sulfonamides; Tetrahydroisoquinolines; Vinblastine	2013
Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine. Molecular pharmaceutics, 2016, 07-05, Volume: 13, Issue:7 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Dexamethasone; Digoxin; Duodenum; Ileum; Intestinal Absorption; Intestine, Small; Jejunum; Loperamide; Mice; Mice, Knockout; Proteomics; Quinidine; Verapamil; Vinblastine	2016
Extrapolation of Elementary Rate Constants of P-glycoprotein-Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Carbamates; Cell Culture Techniques; Cell Membrane; Cell Membrane Permeability; Digoxin; Dogs; Furans; Humans; Kinetics; Loperamide; Madin Darby Canine Kidney Cells; Models, Biological; Quinidine; Sulfonamides	2017