Page last updated: 2024-08-17

quinidine and imipramine

quinidine has been researched along with imipramine in 87 studies

Research

Studies (87)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (25.29)	18.7374
1990's	12 (13.79)	18.2507
2000's	29 (33.33)	29.6817
2010's	20 (22.99)	24.3611
2020's	4 (4.60)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Chiang, GH; Unger, SH	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Akazawa, M; Inui, K; Okuda, M; Saito, H; Urakami, Y	1
Keserü, GM	1
Faassen, F; Spanings, H; Vogel, G; Vromans, H	1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Jia, L; Sun, H	1
Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ	1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Dalvie, D; Loi, CM; Smith, DA	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Handzlik, J; Jastrzębska-Więsek, M; Kieć-Kononowicz, K; Kucwaj-Brysz, K; Latacz, G; Lubelska, A; Partyka, A; Wesołowska, A	1
Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L	1
Abadi, AH; Abdel-Halim, M; Engel, M; Fathalla, RK; Hammam, MA; Hartmann, RW; Hefnawy, A; Keeton, AB; Maher, A; Maxuitenko, Y; Piazza, GA; Racheed, NAS; Sigler, S	1
Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S	1
Consoli, V; D'Agata, V; D'Amico, AG; Fallica, AN; Floresta, G; Intagliata, S; Pittalà, V; Rescifina, A; Romeo, G; Salerno, L; Sorrenti, V; Vanella, L	1
Lagerström, PO; Persson, BA	1
Brøsen, K; Skjelbo, E	1
Brøsen, K; Gram, LF; Kragh-Sørensen, P	1
Brøsen, K; Meyer, UA; Zeugin, T	1
Flatman, PW; Smith, LM	1
Higashi, Y; Murakami, T; Nishiura, A; Toyoda, T; Yata, N	1
Brøsen, K; Gram, LF	1
Roden, DM; Siddoway, LA; Woosley, RL	1
Wood, M	1
Féray, JC; Garay, R	1
Hanano, M; Iga, T; Kurihara, A; Sawada, Y; Sugiyama, Y; Suzuki, H	1
Auclair, MC; Gulda, O; Lechat, P	1
Andersson, KE	2
Baum, T; Eckfeld, DK; Rowles, G; Shropshire, AT; Varner, LL	1
Cheymol, G; Gilbert, JC; Schmitt, H	1
Pillat, B	1
Gaultier, M; Potter, M	1
Cavaliere, TA; Tanz, RD	1
Tellenbach, H	1
Chenzbraun, A; Cohen, AM; Keren, A; Loebel, H; Stern, S; Tzivoni, D; Zahavi, I	1
Bigger, JT; Weld, FM	1
Cittadini, A; Di Francesco, A; Wolf, FI	1
Günther, T; Vormann, J	1
Kanakubo, Y; Kitada, M; Kiuchi, M; Ohmori, S; Rikihisa, T; Takeda, S	1
Sequeira, DJ; Strobel, HW	1
Fernández del Pozo, B; Fernández, C; Pérez-Vizcaíno, F; Tamargo, J; Zaragozá, F	1
Bolton, JL; Nikolic, D; van Breemen, RB	1
Mercure, C; Reudelhuber, TL; Touyz, RM	1
Liu, QY; Wang, XL	1
Mason, JC; Patonay, G; Sowell, J; Strekowski, L	1
Touyz, RM; Yao, G	2
Margolis, JM; Obach, RS	1
Axelsson, H; Floby, E; Granhall, C; Jaksch, Y; Sohlenius-Sternbeck, AK; Svedling, M	1
BORSY, J; FEKETE, M	1
BESSON, H	1
OSBORNE, MW; WINBURY, MM	1
Flarakos, J; Morand, KL; Vouros, P	1
Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA	1
Amad, M; Batonga, J; Bethell, RC; Bolger, G; Cordingley, MG; Duan, J; Garneau, M; Jutras, M; Kukolj, G; Lapeyre, N; Montpetit, H; Otis, F; Rhéaume, M; White, PW	1
Gouda, H; Handa, K; Hirono, S; Nakagome, I; Yamaotsu, N	1
Matsumoto, RR; Nguyen, L	1

Reviews

4 review(s) available for quinidine and imipramine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinical pharmacology of old and new antiarrhythmic drugs. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide	1985
Plasma drug binding: implications for anesthesiologists. Anesthesia and analgesia, 1986, Volume: 65, Issue:7 Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Cardiac Surgical Procedures; Chlorpromazine; Dipyridamole; Disopyramide; Etidocaine; Female; Fentanyl; Half-Life; Humans; Imipramine; Kidney Diseases; Lidocaine; Liver; Mathematics; Meperidine; Methadone; Myocardial Infarction; Orosomucoid; Prazosin; Pregnancy; Propranolol; Protein Binding; Quinidine; Serum Albumin; Sex Factors	1986
Drugs and sudden cardiac death. Annals of the New York Academy of Sciences, 1982, Volume: 382 Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Coronary Disease; Death, Sudden; Diet Fads; Digitalis Glycosides; Diuretics; Drug Interactions; Heart Block; Humans; Hypokalemia; Imipramine; Quinidine	1982

Other Studies

83 other study(ies) available for quinidine and imipramine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity. Journal of medicinal chemistry, 1981, Volume: 24, Issue:3 Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship	1981
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:7 Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Cations; Cell Line; Cloning, Molecular; DNA, Complementary; Genetic Variation; Humans; Kidney; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tetraethylammonium; Tissue Distribution; Transfection	2002
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. International journal of pharmaceutics, 2003, Sep-16, Volume: 263, Issue:1-2 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Determination of log D via automated microfluidic liquid-liquid extraction. Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16 Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results	2011
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
MF-8, a novel promising arylpiperazine-hydantoin based 5-HT Bioorganic & medicinal chemistry letters, 2018, 03-01, Volume: 28, Issue:5 Topics: Dose-Response Relationship, Drug; Humans; Hydantoins; Molecular Structure; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship	2018
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties. European journal of medicinal chemistry, 2020, Aug-15, Volume: 200 Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish	2020
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity. Journal of medicinal chemistry, 2021, 04-22, Volume: 64, Issue:8 Topics: Animals; Blood Proteins; Celecoxib; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Female; Half-Life; Humans; Isoenzymes; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phosphodiesterase 5 Inhibitors; Protein Binding; Pyrazoles; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship	2021
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives. European journal of medicinal chemistry, 2021, Nov-05, Volume: 223 Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones	2021
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18 Topics: Acetamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Male; Molecular Docking Simulation; Molecular Structure; Protein Binding; Rats, Sprague-Dawley; Structure-Activity Relationship	2021
Ion-pair partition chromatography in the analysis of drugs and biogenic substances in plasma and urine. Journal of chromatography, 1976, Jul-07, Volume: 122 Topics: Absorption; Biogenic Amines; Chromatography, Ion Exchange; Chromatography, Liquid; Desipramine; Humans; Hydroxylation; Imipramine; Indoleacetic Acids; Metanephrine; Normetanephrine; Quinidine; Spectrophotometry, Ultraviolet	1976
Inhibitors of imipramine metabolism by human liver microsomes. British journal of clinical pharmacology, 1992, Volume: 34, Issue:3 Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Fluvoxamine; Humans; Hydroxylation; Imipramine; In Vitro Techniques; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Polymorphism, Genetic; Quinidine; Selective Serotonin Reuptake Inhibitors	1992
Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine, and mephenytoin. Therapeutic drug monitoring, 1991, Volume: 13, Issue:2 Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Thin Layer; Debrisoquin; Desipramine; Drug Interactions; Humans; Imipramine; Male; Mephenytoin; Phenotype; Quinidine; Sparteine	1991
Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine. Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:6 Topics: Antibodies; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; DNA; Humans; Imipramine; Isoenzymes; Kidney; Kinetics; Methotrimeprazine; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Polymorphism, Genetic; Quinidine; Sparteine; Transfection	1991
Magnesium transport in ferret red cells. The Journal of physiology, 1990, Volume: 431 Topics: Amiloride; Animals; Biological Transport; Cations, Divalent; Choline; Cobalt; Deoxyglucose; Depression, Chemical; Erythrocytes; Ferrets; Imipramine; In Vitro Techniques; Magnesium; Meglumine; Quinidine; Sodium; Temperature	1990
Phosphatidylserine as a determinant for the tissue distribution of weakly basic drugs in rats. Pharmaceutical research, 1990, Volume: 7, Issue:10 Topics: Animals; Desipramine; Hydrogen-Ion Concentration; Imipramine; Injections, Intravenous; Male; Models, Biological; Phosphatidylserines; Propranolol; Quinidine; Rats; Rats, Inbred Strains; Tissue Distribution	1990
Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine. European journal of clinical pharmacology, 1989, Volume: 37, Issue:2 Topics: Adult; Dealkylation; Desipramine; Drug Interactions; Female; Half-Life; Humans; Hydroxylation; Imipramine; Male; Phenotype; Quinidine; Sparteine	1989
Demonstration of a Na+: Mg2+ exchange in human red cells by its sensitivity to tricyclic antidepressant drugs. Naunyn-Schmiedeberg's archives of pharmacology, 1988, Volume: 338, Issue:3 Topics: Antidepressive Agents, Tricyclic; Biological Transport; Dothiepin; Erythrocytes; Humans; Imipramine; Magnesium; Quinidine; Sodium	1988
Uptake of propranolol by microvessels isolated from bovine brain. Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:10 Topics: 2,4-Dinitrophenol; Adsorption; Animals; Brain; Capillaries; Cattle; Dinitrophenols; Glutamine; Hypothermia; Imipramine; In Vitro Techniques; Microcirculation; Ouabain; Potassium Cyanide; Propranolol; Quinidine	1987
[Electrophysiological analysis of the effects of imipramine on heart ventricle fibre]. Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 181, Issue:1 Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Bicarbonates; Calcium Chloride; Cell Membrane Permeability; Electrodes; Guinea Pigs; Heart; Heart Ventricles; Imipramine; Lactates; Membrane Potentials; Potassium Chloride; Procaine; Quinidine; Rats; Sodium; Tetrodotoxin; Time Factors	1969
Effects of chlorpromazine, imipramine, and quinidine on the mechanical activity of single skeletal muscle fibres of the frog. Acta physiologica Scandinavica, 1972, Volume: 85, Issue:4 Topics: Animals; Anura; Caffeine; Chlorpromazine; Drug Synergism; Electric Stimulation; Imipramine; Methods; Muscle Contraction; Myofibrils; Potassium; Quinidine; Rana temporaria; Tendons	1972
Effects of chlorpromazine, imipramine, and quinidine on action potential and tension development in single skeletal muscle fibres of the frog. Acta physiologica Scandinavica, 1973, Volume: 88, Issue:3 Topics: Action Potentials; Animals; Anura; Chlorpromazine; Dose-Response Relationship, Drug; Electric Stimulation; Imipramine; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle Tonus; Quinidine; Urea	1973
Observations on models used for the evaluation of antiarrhythmic drugs. Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 193, Issue:1 Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Atropine; Benzazepines; Bretylium Compounds; Chlorpheniramine; Diazepam; Disease Models, Animal; Dogs; Drug Antagonism; Guinea Pigs; Imipramine; Ketones; Lidocaine; Male; Meperidine; Mephentermine; Ouabain; Phentolamine; Phenytoin; Procainamide; Promazine; Promethazine; Propranolol; Quinidine	1971
[Antiarrythmic and hemodynamic effects of imipramine and chlorimipramine]. Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 184, Issue:1 Topics: Alkaloids; Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Dibenzazepines; Dogs; Epinephrine; Guinea Pigs; Heart; Heart Rate; Imipramine; In Vitro Techniques; Methods; Ouabain; Quinidine; Rats; Tranquilizing Agents	1970
Prolongation of the relative refractory period by drugs acting like quinidine; occurrence of propagated spikes in cardiac muscle. Helvetica physiologica et pharmacologica acta, 1967, Volume: 25, Issue:1 Topics: Action Potentials; Amitriptyline; Animals; Anti-Arrhythmia Agents; Benzofurans; Cattle; Dibenzothiepins; Heart Ventricles; Imipramine; In Vitro Techniques; Quinidine; Sheep; Sympatholytics; Time Factors; Ventricular Function	1967
[Cardiac reanimation in poisoning]. Semaine therapeutique, 1967, Volume: 43, Issue:3 Topics: Aconitum; Arrhythmias, Cardiac; Digitalis Glycosides; Heart Arrest; Humans; Imipramine; Quinidine; Trichloroethylene	1967
Modified method for determining myocardial refractory period. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 120, Issue:1 Topics: Animals; Cats; Electric Stimulation; Imipramine; In Vitro Techniques; Muscle Contraction; Papillary Muscles; Quinidine; Sympatholytics; Tripelennamine	1965
[Directed treatment of phobia of being hurt (blaptophobia) with imipramine]. Deutsche medizinische Wochenschrift (1946), 1966, Nov-11, Volume: 91, Issue:45 Topics: Bipolar Disorder; Electroconvulsive Therapy; Humans; Imipramine; Phobic Disorders; Quinidine	1966
Magnesium therapy for torsades de pointes. The American journal of cardiology, 1984, Feb-01, Volume: 53, Issue:4 Topics: Aged; Amiodarone; Electrocardiography; Female; Humans; Imipramine; Magnesium Sulfate; Male; Middle Aged; Procainamide; Quinidine; Tachycardia; Thioridazine	1984
Characterization of magnesium efflux from Ehrlich ascites tumor cells. Archives of biochemistry and biophysics, 1994, Feb-01, Volume: 308, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amiloride; Animals; Antimycin A; Bucladesine; Bumetanide; Calcimycin; Carcinoma, Ehrlich Tumor; Colforsin; Cyclic AMP; Energy Metabolism; Glucose; Homeostasis; Imipramine; Kinetics; Magnesium; Mice; Ouabain; Quinidine; Rotenone; Time Factors; Tumor Cells, Cultured	1994
Reversibility of Na+/Mg2+ antiport in rat erythrocytes. Biochimica et biophysica acta, 1995, Mar-08, Volume: 1234, Issue:1 Topics: Adenosine Triphosphate; Amiloride; Animals; Antiporters; Erythrocytes; Imipramine; In Vitro Techniques; Magnesium; Quinidine; Rats; Sodium	1995
Studies on cytochrome P450 responsible for oxidative metabolism of imipramine in human liver microsomes. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:6 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Electrophoresis, Polyacrylamide Gel; Humans; Imipramine; Immunoblotting; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Propranolol; Quinidine; Quinine; Testosterone; Troleandomycin	1993
In vitro metabolism of imipramine by brain microsomes: effects of inhibitors and exogenous cytochrome P450 reductase. Brain research, 1996, Oct-28, Volume: 738, Issue:1 Topics: Animals; Benzoflavones; Brain; Imipramine; In Vitro Techniques; Ketoconazole; Male; Microsomes; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Nerve Tissue Proteins; Osmolar Concentration; Quinidine; Rats; Rats, Sprague-Dawley; Time Factors	1996
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle. General pharmacology, 1997, Volume: 29, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro Techniques; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Quinidine; Rats; Rats, Sprague-Dawley	1997
Metabolic screening using on-line ultrafiltration mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:2 Topics: Animals; Automation; Chlorpromazine; Cytochrome P-450 Enzyme System; Female; Flavanones; Flavonoids; Imipramine; Inactivation, Metabolic; Male; Mass Spectrometry; Microsomes, Liver; Oxazines; Quinidine; Rats; Rats, Sprague-Dawley; Ultrafiltration	1998
Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms. The Journal of biological chemistry, 2001, Apr-27, Volume: 276, Issue:17 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amiloride; Angiotensin II; Animals; Antihypertensive Agents; Benzofurans; Biphenyl Compounds; Calcium; Calcium Channel Agonists; Cell Line; Cells, Cultured; Chelating Agents; Cytosol; Dogs; Dose-Response Relationship, Drug; Egtazic Acid; Ethers, Cyclic; Fluorescent Dyes; Fura-2; Imidazoles; Imipramine; Irbesartan; Kidney; Kinetics; Magnesium; Microscopy, Fluorescence; Peptides; Pyridines; Quinidine; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sodium; Tetrazoles; Time Factors	2001
[The blocking effects of six antiarrhythmic drugs on transient outward current in rat ventricular myocytes]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Imipramine; Male; Myocardium; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Quinidine; Rats; Rats, Wistar; Ventricular Function	1997
Binding constant determination of drugs toward subdomain IIIA of human serum albumin by near-infrared dye-displacement capillary electrophoresis. Electrophoresis, 2001, Volume: 22, Issue:12 Topics: Binding, Competitive; Clofibrate; Coloring Agents; Electrophoresis, Capillary; Humans; Ibuprofen; Imipramine; Indoles; Ketoprofen; Kinetics; Naproxen; Protein Binding; Protein Structure, Tertiary; Quinidine; Serum Albumin; Stereoisomerism; Sulfonic Acids	2001
Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats. Journal of hypertension, 2003, Volume: 21, Issue:2 Topics: Angiotensin II; Animals; Antiporters; Biological Transport; Blood Platelets; Blood Pressure; Body Weight; Cations; Cells, Cultured; Hypertension; Imipramine; Intracellular Membranes; Magnesium; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Quinidine; Rats; Rats, Sprague-Dawley; Sodium; Vasoconstrictor Agents	2003
Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: implications for relating in vitro inhibition data to in vivo drug interactions. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:5 Topics: Benzylamines; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Imipramine; In Vitro Techniques; Microsomes; Phospholipids; Protein Binding; Quinidine	2003
Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger. Clinical science (London, England : 1979), 2003, Volume: 105, Issue:2 Topics: Angiotensin II; Animals; Antiporters; Blood Pressure; Body Weight; Hypertension; Imipramine; Kidney Cortex; Male; Mesenteric Arteries; Mitogen-Activated Protein Kinases; Phosphorylation; Quinidine; Rats; Rats, Sprague-Dawley; Up-Regulation	2003
Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes. Toxicology in vitro : an international journal published in association with BIBRA, 2003, Volume: 17, Issue:4 Topics: Animals; Antidepressive Agents; Antimalarials; Antitussive Agents; Calcium Channel Blockers; Cell Survival; Chlorzoxazone; Coloring Agents; Coumarins; Cryopreservation; Cytochrome P-450 Enzyme System; Dextromethorphan; Imipramine; In Vitro Techniques; Liver; Male; Microsomes, Liver; Muscle Relaxants, Central; Oxazines; Pharmaceutical Preparations; Pharmacokinetics; Quinidine; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Testosterone; Verapamil; Xanthenes	2003
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE). Medicina experimentalis : International journal of experimental medicine, 1964, Volume: 10 Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compounds; Calcium; Cardiac Complexes, Premature; Chlorides; Desipramine; Electrocardiography; Guanethidine; Imipramine; Pharmacology; Quinidine; Rats; Research; Reserpine; Tachycardia; Ventricular Fibrillation	1964
[THE HEART AND POISONINGS]. Maroc medical, 1964, Volume: 43 Topics: Chloroquine; Diagnosis; Digitalis Glycosides; Heart; Heart Failure; Imipramine; Prognosis; Quinidine; Quinine; Toxicology	1964
QUINDONIUM BROMIDE--SOME ASPECTS OF THE CARDIOVASCULAR PHARMACOLOGY. The Journal of pharmacology and experimental therapeutics, 1965, Volume: 147 Topics: Arrhythmias, Cardiac; Blood Pressure; Bromides; Cats; Dogs; Electrocardiography; Epinephrine; Guinea Pigs; Heart; Heart Rate; Hypotension; Ileum; Imipramine; Muscle, Smooth; Ouabain; Pharmacology; Pulse; Pyridines; Quinidine; Quinolines; Rabbits; Research; Toxicology	1965
High-throughput solution-based medicinal library screening against human serum albumin. Analytical chemistry, 2005, Mar-01, Volume: 77, Issue:5 Topics: Acecainide; beta-Lactams; Chromatography, Gel; Chromatography, Liquid; Combinatorial Chemistry Techniques; Dansyl Compounds; Humans; Imipramine; Indomethacin; Pharmaceutical Preparations; Protein Binding; Quinidine; Reproducibility of Results; Sarcosine; Serum Albumin; Tandem Mass Spectrometry; Tryptophan; Warfarin	2005
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:8 Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol	2007
The liver partition coefficient-corrected inhibitory quotient and the pharmacokinetic-pharmacodynamic relationship of directly acting anti-hepatitis C virus agents in humans. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:10 Topics: Animals; Antiviral Agents; Cells, Cultured; Digoxin; Doxorubicin; Hepacivirus; Hepatocytes; Humans; Imipramine; Liver; Male; Mice; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil	2012
In silico study on the inhibitory interaction of drugs with wild-type CYP2D6.1 and the natural variant CYP2D6.17. Drug metabolism and pharmacokinetics, 2014, Volume: 29, Issue:1 Topics: Cocaine; Computer Simulation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Fluoxetine; Imipramine; Molecular Docking Simulation; Molecular Dynamics Simulation; Organic Chemicals; Polymorphism, Genetic; Protein Conformation; Quinidine; Regression Analysis; Stereoisomerism; Thioridazine	2014
Involvement of AMPA receptors in the antidepressant-like effects of dextromethorphan in mice. Behavioural brain research, 2015, Dec-15, Volume: 295 Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder; Dextromethorphan; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hindlimb Suspension; Imipramine; Ketamine; Male; Mice; Quinidine; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Swimming	2015