Compounds > quinidine
Page last updated: 2024-08-17

quinidine and glutamic acid

quinidine has been researched along with glutamic acid in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's2 (25.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Skibitskiĭ, VV1
Gillam, EM; Guengerich, FP; Hanna, IH; Martin, MV1
Appel, SH; Berg, JE; Bradley, WG; Brooks, BR; Olney, RK; Pope, LE; Smith, RA; Thisted, RA1
Flanagan, JU; Kemp, CA; Maréchal, JD; McLaughlin, LA; Paine, MJ; Roberts, GC; Sutcliffe, MJ; Ward, CJ; Wolf, CR1
Crommen, J; Han, H; Jiang, Z; Peng, K; Ruan, M; Wang, Q; Wu, H; Zhu, P1
Ghosh, S; Malik, C1
Hotta, K; Oka, K; Shindo, Y; Yamanaka, R1

Trials

1 trial(s) available for quinidine and glutamic acid

ArticleYear
Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial.
    Neurology, 2004, Oct-26, Volume: 63, Issue:8

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Double-Blind Method; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Male; Metabolic Clearance Rate; Middle Aged; Pseudobulbar Palsy; Quinidine; Receptors, N-Methyl-D-Aspartate; Treatment Outcome

2004

Other Studies

7 other study(ies) available for quinidine and glutamic acid

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
[The potentials of combined anti-arrhythmia therapy with the use of neuroactive amino acids in patients with ischemic heart disease].
    Terapevticheskii arkhiv, 1992, Volume: 64, Issue:8

    Topics: Aged; Angina Pectoris; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Complexes, Premature; Drug Evaluation; Drug Therapy, Combination; Glutamates; Glutamic Acid; Hemodynamics; Humans; Middle Aged; Myocardial Ischemia; Phenothiazines; Physical Exertion; Quinidine; Succinates; Succinic Acid

1992
Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.
    Biochemistry, 2003, Feb-11, Volume: 42, Issue:5

    Topics: Amines; Amino Acid Substitution; Binding Sites; Catalysis; Cytochrome P-450 CYP2D6; Ethanolamines; Glutamic Acid; Glutamine; Humans; Hydroxylation; Methylation; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Binding; Quinidine; Recombinant Proteins; Spiro Compounds; Static Electricity; Substrate Specificity; Sulfonamides; Tyramine

2003
Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.
    The Journal of biological chemistry, 2005, Nov-18, Volume: 280, Issue:46

    Topics: Alanine; Aspartic Acid; Binding Sites; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Escherichia coli; Glutamic Acid; Humans; Kinetics; Mass Spectrometry; Mixed Function Oxygenases; Models, Molecular; Mutation; Oxidoreductases, O-Demethylating; Protein Binding; Protein Structure, Tertiary; Quinidine; Spectrophotometry; Substrate Specificity

2005
Enantioseparation of N-derivatized amino acids by micro-liquid chromatography/laser induced fluorescence detection using quinidine-based monolithic columns.
    Journal of pharmaceutical and biomedical analysis, 2016, Mar-20, Volume: 121

    Topics: Amino Acids; Benzoxazoles; Chromatography, Liquid; Fluorescence; Glutamic Acid; Lasers; Methacrylates; Permeability; Quinidine; Reproducibility of Results; Stereoisomerism

2016
Quinidine partially blocks mitochondrial voltage-dependent anion channel (VDAC).
    European biophysics journal : EBJ, 2020, Volume: 49, Issue:2

    Topics: Animals; Anions; Crystallography, X-Ray; Cysteine; Female; Glutamic Acid; Inhibitory Concentration 50; Male; Mitochondria; Molecular Docking Simulation; Neurons; Oxidative Phosphorylation; Protein Structure, Secondary; Quinidine; Rats; Rats, Wistar; Spectrometry, Fluorescence; Voltage-Dependent Anion Channel 1; Voltage-Dependent Anion Channel 2

2020
Inhibition of Mg
    Nutrients, 2020, Sep-10, Volume: 12, Issue:9

    Topics: Amiloride; Animals; Cells, Cultured; Cytosol; Glutamic Acid; Hippocampus; Magnesium; Mitochondria; Neurons; Quinidine; Rats

2020