quinidine has been researched along with dextrorphan in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bechtel, P; Broly, F; Dupuis, B; Lhermitte, M; Libersa, C | 1 |
| Kalow, W; Otton, SV; Schadel, M; Sellers, EM; Wu, D | 1 |
| Bochner, F; Kerry, NL; Mikus, G; Somogyi, AA | 1 |
| Granda, BW; Grassi, JM; Greenblatt, DJ; Harmatz, JS; Schmider, J; Shader, RI; Venkatakrishnan, K; von Moltke, LL | 1 |
| Abdul-Manap, R; Moghadamnia, AA; Morice, AH; Rostami-Hodjegan, A; Tucker, GT; Wright, CE | 1 |
| Bellward, GD; Chang, TK; Levine, M; Madeira, M; Mirfazaelian, A | 1 |
| Hammond, C; Hargreaves, JA; Rostami-Hodjegan, A; Swales, J; Van, LM; Wilson, C | 1 |
| Bisaga, A; Daniel, WA; Kos, T; Popik, P; Wójcikowski, J | 1 |
| Kwan, YW; Or, PM; Wan, DC; Wang, Y; Yeung, JH; Zhou, X | 1 |
| A, J; Ho, RJ; Liu, J; Liu, K; Peng, Y; Qi, H; Shang, L; Sun, J; Sun, Y; Wang, G; Wu, H; Xiao, Y; Zhang, F; Zhang, X; Zhong, Y; Zhu, J | 1 |
3 trial(s) available for quinidine and dextrorphan
| Article | Year |
|---|---|
Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver.
Topics: Chromatography, High Pressure Liquid; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Dextrorphan; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Oxidoreductases; Oxidoreductases, O-Demethylating; Proteins; Quinidine | 1989 |
Pharmacokinetics of dextromethorphan and metabolites in humans: influence of the CYP2D6 phenotype and quinidine inhibition.
Topics: Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Female; Half-Life; Humans; Male; Mixed Function Oxygenases; Phenotype; Quinidine | 1995 |
Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibition.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Antitussive Agents; Cough; Cross-Over Studies; Dextromethorphan; Dextrorphan; Double-Blind Method; Female; Humans; Male; Quinidine | 2003 |
8 other study(ies) available for quinidine and dextrorphan
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.
Topics: Autoantibodies; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextropropoxyphene; Dextrorphan; Humans; In Vitro Techniques; Methadone; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Perhexiline; Phenotype; Quinidine | 1994 |
Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A.
Topics: Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Quinidine; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Transfection | 1998 |
The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.
Topics: Catalase; Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Edetic Acid; Enzyme Inhibitors; Humans; Kinetics; Microsomes, Liver; NADP; Oxidoreductases, O-Demethylating; Quinidine; Recombinant Proteins; Superoxide Dismutase; Triazoles | 2004 |
Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine (MDMA).
Topics: Algorithms; Cell Count; Cell Survival; Cryopreservation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Enzyme Stability; Hepatocytes; Humans; Kinetics; N-Methyl-3,4-methylenedioxyamphetamine; Quinidine; Time Factors | 2007 |
Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice.
Topics: Animals; Brain; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Drug Synergism; Male; Mastication; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Motor Activity; Naloxone; Narcotic Antagonists; Quinidine; Stereotyped Behavior; Substance Withdrawal Syndrome | 2008 |
Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes.
Topics: Abietanes; Amino Acids; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dextrorphan; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Kinetics; Microsomes, Liver; Phenanthrolines; Protein Binding; Quinidine; Salvia miltiorrhiza | 2012 |
Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms.
Topics: Aconitum; Alkaloids; Animals; Anti-Arrhythmia Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dextrorphan; Dogs; Drug Interactions; Female; Haplorhini; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Mice; Microsomes, Liver; Protein Isoforms; Quinidine; Rats | 2015 |