Page last updated: 2024-08-17

quinidine and debrisoquin

quinidine has been researched along with debrisoquin in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199012 (31.58)18.7374
1990's16 (42.11)18.2507
2000's9 (23.68)29.6817
2010's1 (2.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Commandeur, JN; Funae, Y; Hiroi, T; ter Laak, AM; Venhorst, J; Vermeulen, NP1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Araki, J; Masubuchi, Y; Narimatsu, S; Suzuki, T1
Bélanger, PM; Eichelbaum, M; Fiset, C; Giguère, R; Gilbert, M; Grech-Bélanger, O; Kroemer, HK; Moerike, K; Rouleau, JR; Turgeon, J1
Ayesh, R; Cholerton, S; Dawling, S; Hayler, A; Idle, JR; Oates, NS; Smith, RL; Widdop, B1
Broly, F; Caron, J; Lhermitte, M; Libersa, C; Vandamme, N1
Brøsen, K; Gram, LF; Kragh-Sørensen, P1
Brøsen, K; Meyer, UA; Zeugin, T1
Anthony, LB; Roden, DM; Wood, AJ; Zhou, HH1
Gonzalez, FJ; Hardwick, JP; Inaba, T; Kalow, W; Tyndale, RF1
Funck-Brentano, C; Roden, DM; Turgeon, J; Woosley, RL1
Agron, L; Bigot, MC; Camsonne, R; Dao, MT; Debruyne, D; Gram, LF; Grollier, G; Lacotte, J; Moulin, M1
Dahlqvist, R; Dumont, E; Spina, E; Steiner, E1
Boobis, AR; Davies, DS; Kobayashi, S; Murray, S; Sesardic, D; Watson, D1
Hawes, EM; Inaba, T; McKay, G; Midha, KK; Muralidharan, G1
Crewe, HK; Lennard, MS; Otton, SV; Tucker, GT; Woods, HF1
Boobis, AR; Davies, DS; Murray, S; Seddon, CE; Speirs, CJ1
Bertilsson, L; Brøsen, K; Gram, LF; Haghfelt, T1
Dayer, P; Eichelbaum, M; Kronbach, T; Meyer, UA1
Dayer, P; Leemann, T; Meyer, UA1
Inaba, T; Mahon, WA; Tyndale, RE1
Almeyda, J; Levantine, A1
Huang, Y; Masubuchi, Y; Mizukami, T; Narimatsu, S; Suzuki, T2
Bertilsson, L; Dahl, ML; Eichelbaum, M; Ingelman-Sundberg, M; Johansson, I; Meese, CO; Säwe, J; Yue, QY1
Dayer, P; Devi, KP; Leemann, TD1
Ebner, T; Eichelbaum, M1
Cooper, JK; Hawes, EM; Korchinski, ED; Midha, KK; Muralidharan, G1
Caraco, Y; Sheller, J; Wood, AJ2
Blackburn, MG; Ellis, SW; Harlow, J; Hayhurst, GP; Larsson, C; Lennard, MS; Lightfoot, T; Lim, CK; Mahling, J; Rowland-Yeo, K; Smith, G; Tucker, GT; Wolf, CR1
Andersson, K; Bertilsson, L; Dahl, M; Dalén, P1
Chiba, M; Lin, JH; Lin, Y; Neway, W; Nishime, JA1
Adedoyin, A; Branch, RA; Frye, RF; Romkes, M; Wilson, JW1
Gelboin, HV; Gonzalez, FJ; Granvil, CP; Idle, JR; Krausz, KW1
Katoh, M; Nakajima, M; Sawada, T; Soeno, Y; Tateno, C; Yokoi, T; Yoshizato, K1
Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA1

Reviews

2 review(s) available for quinidine and debrisoquin

ArticleYear
Inhibition of desipramine 2-hydroxylation by quinidine and quinine in rapid and slow debrisoquine hydroxylators.
    Psychopharmacology series, 1989, Volume: 7

    Topics: Debrisoquin; Depression, Chemical; Desipramine; Humans; Hydroxylation; Isoquinolines; Phenotype; Quinidine; Quinine

1989
Cutaneous reactions to cardiovascular drugs.
    The British journal of dermatology, 1973, Volume: 88, Issue:3

    Topics: Adrenergic beta-Antagonists; Cardiovascular Diseases; Clonidine; Debrisoquin; Digitalis Glycosides; Drug Eruptions; Ethacrynic Acid; Furosemide; Guanethidine; Humans; Hydralazine; Mercury; Methyldopa; Nitroglycerin; Pentaerythritol Tetranitrate; Procainamide; Quinidine; Thiazines

1973

Trials

5 trial(s) available for quinidine and debrisoquin

ArticleYear
Effect of low dose quinidine on encainide pharmacokinetics and pharmacodynamics. Influence of genetic polymorphism.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:1

    Topics: Adult; Anilides; Biological Availability; Debrisoquin; Drug Interactions; Electrocardiography; Encainide; Humans; Male; Metabolic Clearance Rate; Middle Aged; Polymorphism, Genetic; Quinidine

1989
Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine.
    European journal of clinical pharmacology, 1996, Volume: 50, Issue:1-2

    Topics: Adult; Antipsychotic Agents; Chlorpromazine; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Depression, Chemical; Enzyme Inhibitors; Humans; Hydroxylation; Male; Mixed Function Oxygenases; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Quinidine

1996
Pharmacogenetic determination of the effects of codeine and prediction of drug interactions.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3

    Topics: Adult; Codeine; Cross-Over Studies; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Double-Blind Method; Drug Interactions; Humans; Male; Pupil; Quinidine; Reflex, Pupillary; Respiration

1996
Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:1

    Topics: Adult; Analgesics, Opioid; Asian People; Biotransformation; Codeine; Cross-Over Studies; Dealkylation; Debrisoquin; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Morphine; Psychomotor Performance; Pupil; Quinidine; Respiratory Mechanics; White People

1999
Inhibition of debrisoquine hydroxylation with quinidine in subjects with three or more functional CYP2D6 genes.
    British journal of clinical pharmacology, 2000, Volume: 49, Issue:2

    Topics: Administration, Oral; Adult; Alleles; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Dosage; Genotype; Humans; Hydroxylation; Male; Quinidine

2000

Other Studies

31 other study(ies) available for quinidine and debrisoquin

ArticleYear
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.
    Journal of medicinal chemistry, 2003, Jan-02, Volume: 46, Issue:1

    Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Coumarins; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; Ligands; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Protein Binding; Quinidine; Quinine; Rabbits; Rats; Sequence Homology, Amino Acid; Sparteine; Species Specificity

2003
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Metabolic activation of lidocaine and covalent binding to rat liver microsomal protein.
    Biochemical pharmacology, 1992, Jun-23, Volume: 43, Issue:12

    Topics: Animals; Biotransformation; Carbon Monoxide; Cysteine; Cytochrome P-450 Enzyme System; Debrisoquin; Dose-Response Relationship, Drug; Female; Glutathione; Lidocaine; Male; Microsomes, Liver; NADP; Oxygen; Proadifen; Propranolol; Proteins; Quinidine; Rats; Rats, Inbred Strains

1992
Influence of debrisoquine phenotype and of quinidine on mexiletine disposition in man.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2

    Topics: Administration, Oral; Adult; Debrisoquin; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Phenotype; Polymorphism, Genetic; Quinidine

1991
Comparative effects of the diastereoisomers, quinine and quinidine in producing phenocopy debrisoquine poor metabolisers (PMs) in healthy volunteers.
    Chirality, 1991, Volume: 3, Issue:1

    Topics: Adult; Debrisoquin; Desipramine; Female; Humans; Male; Metabolic Clearance Rate; Molecular Structure; Nortriptyline; Phenotype; Quinidine; Quinine; Reference Values; Stereoisomerism

1991
Single-dose quinidine treatment inhibits mexiletine oxidation in extensive metabolizers of debrisoquine.
    Life sciences, 1991, Volume: 48, Issue:26

    Topics: Debrisoquin; Drug Antagonism; Humans; Metabolic Clearance Rate; Mexiletine; Oxidation-Reduction; Quinidine

1991
Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine, and mephenytoin.
    Therapeutic drug monitoring, 1991, Volume: 13, Issue:2

    Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Thin Layer; Debrisoquin; Desipramine; Drug Interactions; Humans; Imipramine; Male; Mephenytoin; Phenotype; Quinidine; Sparteine

1991
Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine.
    Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:6

    Topics: Antibodies; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; DNA; Humans; Imipramine; Isoenzymes; Kidney; Kinetics; Methotrimeprazine; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Polymorphism, Genetic; Quinidine; Sparteine; Transfection

1991
Quinidine reduces clearance of (+)-propranolol more than (-)-propranolol through marked reduction in 4-hydroxylation.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:6

    Topics: Adult; Analysis of Variance; Debrisoquin; Drug Interactions; Electrocardiography; Humans; Hydroxylation; Male; Metabolic Clearance Rate; Propranolol; Quinidine; Stereoisomerism

1990
Sparteine metabolism capacity in human liver: structural variants of human P450IID6 as assessed by immunochemistry.
    Pharmacology & toxicology, 1990, Volume: 67, Issue:1

    Topics: Animals; Blotting, Western; Cytochrome P-450 Enzyme System; Debrisoquin; Ethanolamines; Humans; Immunochemistry; In Vitro Techniques; Kinetics; Liver; Quinidine; Rats; Rats, Inbred Strains; Sparteine

1990
Quinidine disposition in relation to antipyrine elimination and debrisoquine phenotype in alcoholic patients with and without cirrhosis.
    International journal of clinical pharmacology research, 1989, Volume: 9, Issue:5

    Topics: Adult; Aged; Alcoholism; Antipyrine; Chromatography, Liquid; Debrisoquin; Female; Half-Life; Humans; Isoquinolines; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Quinidine

1989
The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man.
    Biochemical pharmacology, 1989, Sep-01, Volume: 38, Issue:17

    Topics: Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Debrisoquin; Humans; In Vitro Techniques; Liver; Male; Mixed Function Oxygenases; Quinidine; Quinine; Rats; Rats, Inbred Strains; Species Specificity

1989
Selective in vivo inhibition by quinidine of methoxyphenamine oxidation in rat models of human debrisoquine polymorphism.
    Xenobiotica; the fate of foreign compounds in biological systems, 1989, Volume: 19, Issue:2

    Topics: Amphetamines; Animals; Debrisoquin; Female; Humans; Isoquinolines; Methamphetamine; Polymorphism, Genetic; Quinidine; Rats; Rats, Inbred Lew; Rats, Inbred Strains

1989
Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:1

    Topics: Cytochrome P-450 Enzyme System; Dealkylation; Debrisoquin; Humans; Hydroxylation; In Vitro Techniques; Isoquinolines; Kinetics; Metoprolol; Microsomes, Liver; Quinidine; Quinine; Sparteine

1988
Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:6

    Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; In Vitro Techniques; Isoenzymes; Isoquinolines; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenotype; Quinidine; Quinine

1986
Extensive metabolizers of debrisoquine become poor metabolizers during quinidine treatment.
    Pharmacology & toxicology, 1987, Volume: 60, Issue:4

    Topics: Aged; Debrisoquin; Depression, Chemical; Humans; Hydroxylation; Isoquinolines; Male; Middle Aged; Phenotype; Quinidine

1987
Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation. Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency.
    Biochemical pharmacology, 1987, Dec-01, Volume: 36, Issue:23

    Topics: Adult; Aged; Binding, Competitive; Cytochrome P-450 Enzyme System; Debrisoquin; Ethanolamines; Humans; Hydroxylation; Isoenzymes; Isoquinolines; Kinetics; Microsomes, Liver; Middle Aged; Phenotype; Polymorphism, Genetic; Quinidine; Sparteine

1987
Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers.
    European journal of clinical pharmacology, 1986, Volume: 29, Issue:6

    Topics: Adult; Debrisoquin; Depression, Chemical; Humans; Metoprolol; Oxidation-Reduction; Quinidine; Stereoisomerism

1986
Quinidine: potent inhibition of sparteine and debrisoquine oxidation in vivo.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:2

    Topics: Adult; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Isoquinolines; Male; Middle Aged; Oxidation-Reduction; Quinidine; Sparteine

1986
Development of a high-performance liquid chromatographic method for the analysis of enatiomer/enantiomer interaction in oxidative metabolism of bunitrolol in rat liver microsomes.
    Analytical biochemistry, 1994, Volume: 222, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Chromatography, High Pressure Liquid; Debrisoquin; Gas Chromatography-Mass Spectrometry; Male; Microsomes, Liver; Oxidation-Reduction; Propanolamines; Quinidine; Quinine; Rats; Rats, Wistar; Stereoisomerism

1994
Quinidine inhibition of debrisoquine S(+)-4- and 7-hydroxylations in Chinese of different CYP2D6 genotypes.
    Pharmacogenetics, 1993, Volume: 3, Issue:2

    Topics: Asian People; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Genotype; Haplotypes; Humans; Hydroxylation; Metabolic Clearance Rate; Mixed Function Oxygenases; Polymorphism, Restriction Fragment Length; Quinidine; Stereoisomerism; White People

1993
Similar effect of oxidation deficiency (debrisoquine polymorphism) and quinidine on the apparent volume of distribution of (+/-)-metoprolol.
    European journal of clinical pharmacology, 1993, Volume: 45, Issue:1

    Topics: Adult; Blood Proteins; Debrisoquin; Drug Interactions; Humans; Male; Metoprolol; Phenotype; Polymorphism, Genetic; Protein Binding; Quinidine

1993
The metabolism of aprindine in relation to the sparteine/debrisoquine polymorphism.
    British journal of clinical pharmacology, 1993, Volume: 35, Issue:4

    Topics: Aprindine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Hydroxylation; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Polymorphism, Genetic; Propafenone; Quinidine; Sparteine

1993
In-vitro metabolic interaction of bunitrolol enantiomers in rabbit liver microsomes.
    The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:11

    Topics: Adrenergic beta-Antagonists; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Propanolamines; Quinidine; Quinine; Rabbits; Rats; Rats, Wistar; Species Specificity; Stereoisomerism

1996
Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.
    The Biochemical journal, 2000, Feb-01, Volume: 345 Pt 3

    Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Binding Sites; Catalytic Domain; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Enzyme Inhibitors; Kinetics; Ligands; Metoprolol; Mutagenesis, Site-Directed; Oxidation-Reduction; Propranolol; Quinidine; Quinine; Serine; Substrate Specificity; Yeasts

2000
Comparative in vitro metabolism of indinavir in primates--a unique stereoselective hydroxylation in monkey.
    Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; HIV Protease Inhibitors; Humans; Hydroxylation; Indinavir; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Molecular Conformation; Molecular Structure; Primates; Quinidine; Quinine

2000
In vivo modulation of CYP enzymes by quinidine and rifampin.
    Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:4

    Topics: Acetylation; Administration, Oral; Adrenergic alpha-Antagonists; Adult; Anti-Arrhythmia Agents; Antibiotics, Antitubercular; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Administration Schedule; Enzyme Inhibitors; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Quinidine; Reference Values; Rifampin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline

2000
4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:3

    Topics: Adrenergic Agents; Antimalarials; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxylation; Microsomes; Quinidine; Quinine

2002
In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver.
    Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:2

    Topics: Adrenergic Agents; Animals; Chimera; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Drug Interactions; Humans; Infant; Liver; Male; Mice; Mice, SCID; Models, Animal; Paroxetine; Quinidine; Urokinase-Type Plasminogen Activator

2007
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:8

    Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol

2007