Page last updated: 2024-08-17

quinidine and cyclosporine

quinidine has been researched along with cyclosporine in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (17.14)	18.2507
2000's	29 (41.43)	29.6817
2010's	26 (37.14)	24.3611
2020's	3 (4.29)	2.80

Authors

Authors	Studies
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Inui, KI; Ito, T; Tanaka, K; Yano, I	1
Choo, EF; Imamura, H; Kim, RB; Leake, B; Wandel, C; Wilkinson, GR; Wood, AJ	1
Aubé, J; Borchardt, RT; Gao, J; Murase, O; Schowen, RL	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	2
Adachi, Y; Sugiyama, Y; Suzuki, H	1
Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y	1
Borchardt, RT; Horie, K; Tang, F	3
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Nezu, J; Nozawa, T; Sai, Y; Tamai, I; Tsuji, A	1
Thakker, DR; Troutman, MD	1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Dai, R; Liu, Y; She, M; Wu, Z	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Brincat, JP; Broccatelli, F; Carosati, E; Cruciani, G; Frosini, M; Kaatz, GW; Neri, A; Sabatini, S	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bae, S; Cho, Y; Choi, J; Kang, JA; Kim, YC; Lee, D; Lim, C; Park, M; Park, SG; Seo, J	1
Fardel, O; Guillouzo, A; Ketterer, B; Loyer, P; Ratanasavanh, D	1
Charuk, J; De Lannoy, IA; Klein, J; Koren, G; Silverman, M	1
de Lannoy, IA; Silverman, M	1
Hunt, CM; Stave, GM; Westerkam, WR	1
Gottesman, MM; Mickisch, GH; Pastan, I	1
Aksentijevich, I; Cardarelli, CO; Gottesman, MM; Pastan, I	1
Patterson, FK; Wigler, PW	1
Hill, BT; Hosking, LK	1
Algour, N; Ayesh, S; Lyubimov, E; Stein, WD	1
Ito, S; Koren, G; Woodland, C	1
Lay, RH; Medh, RD; Schmidt, TJ	1
Benet, LZ; Lantz, MV; Parasrampuria, DA	1
Bigler, L; Follath, F; Ha, HR; Kozlik, P; Stieger, B	1
Sakai, K; Sato, F; Shitan, N; Ueda, K; Yazaki, K	1
Haehner, T; Müller-Enoch, D; Refaie, MO	1
Tsai, PL; Tsai, TH	2
Panchagnula, R; Varma, MV	1
Asashi, S; Higuchi, T; Katoh, M; Suzuyama, N; Takeuchi, T; Yokoi, T; Yoshitomi, S	1
Bermejo, M; Casabó-Alós, VG; Fernández-Teruel, C; Garrigues, TM; González-Alvarez, I; Polli, JE; Ruiz-García, A	1
Bui, T; Ho, RJ; Hsiao, P; Unadkat, JD	1
Liu, C; Pei, Y; Wei, Y; Zhou, Y; Zhu, S	1
Mealey, KL; Nelson, FR; Raunig, DL; Schmidt, KR; Waiting, D	1
Be, X; Berry, L; Chen, A; Huang, L; Janosky, B; Lin, MH; Roberts, J	1
Li, H; Shen, GL; Sun, HX; Yuan, M; Zhuang, XM	1
Barot, M; Gokulgandhi, MR; Mitra, AK; Pal, D	1
Ahmed, Z; Bentz, J; Ellens, H; Hidalgo, IJ; Li, J; Li, L; Lumen, AA; Meng, Z; Owen, A	1
Fukami, T; Suzuki, T; Tomono, K	1
de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M	1
Aoki, S; Horie, T; Ito, K; Ogimura, E; Oizumi, K; Sekine, S; Susukida, T	1
Bernkop-Schnürch, A; Laffleur, F; Netsomboon, K; Suchaoin, W	1
Endo, T; Fujii, Y; Haraguchi, K; Kato, Y; Kimura, O; Koga, N; Ohta, C	1
Becker, C; Cao, L; Capparelli, M; Denay, R; Fu, J; Fujimoto, R; Gai, Y; Gallou, F; Gao, Z; Guenat, C; Karur, S; Kim, H; Li, W; Li, X; Lochmann, T; Lu, A; Lu, P; Luneau, A; Meier, N; Mergo, W; Ng, S; Parker, D; Peng, Y; Riss, B; Rivkin, A; Roggo, S; Schroeder, H; Schuerch, F; Simmons, RL; Sun, F; Sweeney, ZK; Tjandra, M; Wang, M; Wang, R; Weiss, AH; Wenger, N; Wu, Q; Xiong, X; Xu, S; Xu, W; Yifru, A; Zhao, J; Zhou, J; Zürcher, C	1
Anderson, MS; Bertz, R; Bhardwaj, R; Collins, JL; Coric, V; Croop, R; Finley, JA; Madonia, J; Stock, DA; Stringfellow, J	1

Reviews

4 review(s) available for quinidine and cyclosporine

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
In vivo models of P-glycoprotein-mediated multidrug resistance. Cancer treatment and research, 1994, Volume: 73 Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clone Cells; Cloning, Molecular; Cyclosporine; Drug Resistance, Multiple; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Quinidine; Recombinant Fusion Proteins; Reproducibility of Results; Research Design; Sensitivity and Specificity; Transplantation, Heterologous; Tumor Cells, Cultured; Verapamil	1994
Toxic digoxin-drug interactions: the major role of renal P-glycoprotein. Veterinary and human toxicology, 1998, Volume: 40, Issue:1 Topics: Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporine; Digoxin; Drug Interactions; Glomerular Filtration Rate; Humans; Itraconazole; Kidney Tubules; Quinidine; Verapamil	1998

Trials

2 trial(s) available for quinidine and cyclosporine

Article	Year
Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs. Journal of veterinary pharmacology and therapeutics, 2010, Volume: 33, Issue:5 Topics: Animals; Anti-Anxiety Agents; Antidiarrheals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cross-Over Studies; Cyclosporine; Diazepam; Dogs; Enzyme Inhibitors; Female; Genotype; HIV Protease Inhibitors; Loperamide; Male; Nelfinavir; Quinidine; Substrate Specificity	2010
P-Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects. Clinical pharmacology in drug development, 2022, Volume: 11, Issue:7 Topics: ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cross-Over Studies; Cyclosporine; Female; Healthy Volunteers; Humans; Membrane Transport Proteins; Neoplasm Proteins; Piperidines; Pyridines; Quinidine	2022

Article

Year

Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs.

Journal of veterinary pharmacology and therapeutics, 2010, Volume: 33, Issue:5

Topics: Animals; Anti-Anxiety Agents; Antidiarrheals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cross-Over Studies; Cyclosporine; Diazepam; Dogs; Enzyme Inhibitors; Female; Genotype; HIV Protease Inhibitors; Loperamide; Male; Nelfinavir; Quinidine; Substrate Specificity

2010

P-Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects.

Clinical pharmacology in drug development, 2022, Volume: 11, Issue:7

Topics: ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cross-Over Studies; Cyclosporine; Female; Healthy Volunteers; Humans; Membrane Transport Proteins; Neoplasm Proteins; Piperidines; Pyridines; Quinidine

2022

Other Studies

64 other study(ies) available for quinidine and cyclosporine

Article	Year
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2 Topics: Animals; Anti-Infective Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Daunorubicin; Epithelial Cells; Epithelium; Fluoroquinolones; Humans; Kidney; Levofloxacin; LLC-PK1 Cells; Ofloxacin; Quinolones; Swine	1997
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:6 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Caco-2 Cells; Dibenzocycloheptenes; HIV Protease Inhibitors; Humans; Inhibitory Concentration 50; Male; Mice; Quinolines; Testis	2000
A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharmaceutical research, 2001, Volume: 18, Issue:2 Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Biological Transport, Active; Caco-2 Cells; Drug Interactions; Humans; Ligands; Models, Theoretical; Paclitaxel; Tritium	2001
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2 Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors	2001
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharmaceutical research, 2001, Volume: 18, Issue:12 Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Hydrolysis; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Models, Biological; Pharmaceutical Preparations; Swine; Tissue Distribution; Transfection	2001
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharmaceutical research, 2002, Volume: 19, Issue:2 Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine	2002
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharmaceutical research, 2002, Volume: 19, Issue:6 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genes, MDR; Humans; Intestinal Mucosa; Transfection	2002
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharmaceutical research, 2002, Volume: 19, Issue:6 Topics: Animals; Caco-2 Cells; Cell Line; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Mitochondrial Proteins; Multidrug Resistance-Associated Protein 2; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Transfection; Vinblastine	2002
Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharmaceutical research, 2003, Volume: 20, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Clone Cells; Dogs; Gene Expression Regulation; Humans	2003
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharmaceutical research, 2003, Volume: 20, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans	2003
Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:7 Topics: Animals; Anions; Bile; Biological Transport; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Estrone; Hepatocytes; In Vitro Techniques; Injections, Intravenous; Liver-Specific Organic Anion Transporter 1; Oocytes; Peptides; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Xenopus laevis	2003
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharmaceutical research, 2003, Volume: 20, Issue:8 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics	2003
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3 Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Ligand Promiscuity between the Efflux Pumps Human P-Glycoprotein and S. aureus NorA. ACS medicinal chemistry letters, 2012, Mar-08, Volume: 3, Issue:3 Topics:	2012
Entry inhibition of hepatitis B virus using cyclosporin O derivatives with peptoid side chain incorporation. Bioorganic & medicinal chemistry, 2022, 08-15, Volume: 68 Topics: Antiviral Agents; Cyclosporins; Hepatitis B; Hepatitis B virus; Humans; Imidazoles; Liver Neoplasms; Organic Anion Transporters, Sodium-Dependent; Peptoids; Sulfonamides; Symporters; Thiophenes; Virus Internalization	2022
Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture. European journal of biochemistry, 1992, Apr-15, Volume: 205, Issue:2 Topics: Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Cell Membrane; Cell Survival; Cells, Cultured; Cyclosporine; Doxorubicin; Drug Resistance; Gene Expression; Liver; Male; Membrane Glycoproteins; Nifedipine; Quinidine; Rats; Rats, Inbred Strains; RNA, Messenger; Verapamil; Vincristine	1992
Cyclosporin and quinidine inhibition of renal digoxin excretion: evidence for luminal secretion of digoxin. The American journal of physiology, 1992, Volume: 263, Issue:4 Pt 2 Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Digoxin; Dogs; Female; Kidney; Male; Membrane Glycoproteins; Ouabain; Quinidine	1992
The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Biochemical and biophysical research communications, 1992, Nov-30, Volume: 189, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; CHO Cells; Colchicine; Cricetinae; Cyclosporine; Digoxin; Dose-Response Relationship, Drug; Drug Resistance; Kinetics; Membrane Glycoproteins; Quinidine; Verapamil; Vinblastine	1992
Effect of age and gender on the activity of human hepatic CYP3A. Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Humans; Lidocaine; Microsomes, Liver; Middle Aged; Nifedipine; Oxidoreductases, N-Demethylating; Quinidine; Sex Factors; Smoking	1992
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters. Cancer research, 1995, Mar-01, Volume: 55, Issue:5 Topics: 3T3 Cells; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carrier Proteins; Cell Death; Cell Survival; Colchicine; Cyclosporine; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Membrane Glycoproteins; Mice; Phenotype; Point Mutation; Quinidine; Transfection; Verapamil	1995
Reversal agent inhibition of the multidrug resistance pump in human leukemic lymphoblasts. Biochimica et biophysica acta, 1994, Jan-03, Volume: 1189, Issue:1 Topics: Amiodarone; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Drug Resistance; Humans; Leukemia; Membrane Glycoproteins; Propranolol; Propylamines; Quinidine; Quinine; Rhodamine 123; Rhodamines; Stereoisomerism; Tumor Cells, Cultured	1994
Differential effectiveness of a range of novel drug-resistance modulators, relative to verapamil, in influencing vinblastine or teniposide cytotoxicity in human lymphoblastoid CCRF-CEM sublines expressing classic or atypical multidrug resistance. Cancer chemotherapy and pharmacology, 1994, Volume: 33, Issue:4 Topics: Cyclosporine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Flunarizine; Humans; Leukemia, T-Cell; Piperidines; Quinidine; Teniposide; Triazines; Tumor Cells, Cultured; Verapamil; Vinblastine	1994
Reversal of P-glycoprotein is greatly reduced by the presence of plasma but can be monitored by an ex vivo clinical assay. Anti-cancer drugs, 1996, Volume: 7, Issue:6 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug Screening Assays, Antitumor; Humans; Kidney; Leukemia P388; Mice; Plasma; Quinidine; Verapamil; Vinblastine	1996
Agonist-specific modulation of glucocorticoid receptor-mediated transcription by immunosuppressants. Molecular and cellular endocrinology, 1998, Mar-16, Volume: 138, Issue:1-2 Topics: Animals; Corticosterone; Cortodoxone; Cyclosporine; Desoxycorticosterone; Dexamethasone; Genes, Reporter; Glucocorticoids; Hydrocortisone; Immunosuppressive Agents; L Cells; Luciferases; Mice; Polyenes; Quinidine; Receptors, Glucocorticoid; Recombinant Fusion Proteins; Sirolimus; Tacrolimus; Transcription, Genetic; Transfection; Triamcinolone Acetonide; Verapamil	1998
A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. Pharmaceutical research, 2001, Volume: 18, Issue:1 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Separation; Cyclosporine; Enzyme Inhibitors; Fluorescent Dyes; Humans; Immunosuppressive Agents; Lymphocytes; Quinidine; Rhodamine 123; Tacrolimus; Verapamil	2001
Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:5 Topics: Amiodarone; Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ketoconazole; Kinetics; Microsomes, Liver; Midazolam; Models, Chemical; Oxidoreductases, N-Demethylating; Protein Isoforms; Quinidine; Rabbits; Rifampin; Time Factors	2001
Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein. Journal of experimental botany, 2002, Volume: 53, Issue:376 Topics: Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Azides; Berberine; Biological Transport; Cells, Cultured; Cyclosporine; Genes, MDR; Hydrogen-Ion Concentration; Lithospermum; Macrolides; Nicotiana; Nifedipine; Quinidine; Ranunculaceae; Vacuoles; Vanadates	2002
Drug-drug interactions evaluated by a highly active reconstituted native human cytochrome P4503A4 and human NADPH-cytochrome P450 reductase system. Arzneimittel-Forschung, 2004, Volume: 54, Issue:1 Topics: Antifungal Agents; Antimalarials; Catalysis; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Estrogen Antagonists; Ethinyl Estradiol; Flavanones; Hormone Antagonists; Humans; Immunosuppressive Agents; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Mifepristone; NADPH-Ferrihemoprotein Reductase; Phospholipids; Quinidine; Quinine; Tacrolimus	2004
Hepatobiliary excretion of berberine. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:4 Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Berberine; Bile; Chromatography, High Pressure Liquid; Cyclosporine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Glucuronides; Half-Life; Injections, Intravenous; Liver; Male; Methylation; Microdialysis; Organic Cation Transport Proteins; Proadifen; Probenecid; Quinidine; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Time Factors	2004
Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study. Planta medica, 2004, Volume: 70, Issue:11 Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Blood-Brain Barrier; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Flavonoids; Glucuronidase; Male; Microdialysis; Phytotherapy; Plant Extracts; Plant Roots; Proadifen; Quinidine; Rats; Rats, Sprague-Dawley; Scutellaria baicalensis	2004
Prediction of in vivo intestinal absorption enhancement on P-glycoprotein inhibition, from rat in situ permeability. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:8 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Dose-Response Relationship, Drug; Humans; Ileum; Intestinal Absorption; Models, Biological; Perfusion; Permeability; Predictive Value of Tests; Quinidine; Rats; Rats, Sprague-Dawley; Solubility	2005
Species differences of inhibitory effects on P-glycoprotein-mediated drug transport. Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:6 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Daunorubicin; Digoxin; Dogs; Dose-Response Relationship, Drug; Humans; Mice; Quinidine; Rats; Species Specificity; Verapamil	2007
In situ kinetic modelling of intestinal efflux in rats: functional characterization of segmental differences and correlation with in vitro results. Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:5 Topics: Algorithms; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Ciprofloxacin; Colon; Cyclosporine; Dose-Response Relationship, Drug; Fluoroquinolones; Immunosuppressive Agents; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Kinetics; Male; Models, Biological; Molecular Structure; Muscarinic Antagonists; p-Aminohippuric Acid; Permeability; Quinidine; Rats; Rats, Wistar; Vasodilator Agents; Verapamil	2007
In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Boron Compounds; Carbamates; Carbon Radioisotopes; Cyclosporine; Drug Interactions; Fluorescent Dyes; Furans; Humans; LLC-PK1 Cells; Positron-Emission Tomography; Quinidine; Quinine; Rats; Sulfonamides; Swine; Verapamil	2008
In situ intestinal absorption of cyclosporine A solid dispersion in rats. Drug development and industrial pharmacy, 2008, Volume: 34, Issue:6 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Cyclosporine; Diffusion; Drug Carriers; Immunosuppressive Agents; Intestinal Absorption; Male; Polyethylene Glycols; Quinidine; Rats; Rats, Sprague-Dawley; Solubility	2008
Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds. Xenobiotica; the fate of foreign compounds in biological systems, 2012, Volume: 42, Issue:9 Topics: Animals; Bosentan; Capillary Permeability; Chromatography, Liquid; Cyclosporine; Dogs; Fluorobenzenes; Hepatocytes; Madin Darby Canine Kidney Cells; Male; Metabolic Clearance Rate; Pyrimidines; Quinidine; Rats; Rats, Sprague-Dawley; Rifampin; Rosuvastatin Calcium; Sulfonamides; Tandem Mass Spectrometry; Verapamil; Xenobiotics	2012
[Evaluation of P-glycoprotein mediated in vitro loperamide biliary excretion with sandwich-cultured rat hepatocytes model]. Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:4 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclosporine; Hepatocytes; Loperamide; Male; Quinidine; Quinolines; Rats; Rats, Sprague-Dawley; Rhodamine 123; Tandem Mass Spectrometry	2012
Mitochondrial localization of P-glycoprotein and peptide transporters in corneal epithelial cells--novel strategies for intracellular drug targeting. Experimental eye research, 2013, Volume: 106 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Blotting, Western; Carbocyanines; Cells, Cultured; Cyclosporine; Dipeptides; Drug Delivery Systems; Epithelium, Corneal; Flow Cytometry; Fluorescent Dyes; Membrane Potential, Mitochondrial; Microscopy, Confocal; Microscopy, Electron, Transmission; Mitochondria; Peptide Transporter 1; Quinidine; Rabbits; Rhodamine 123; Symporters	2013
Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp. PloS one, 2013, Volume: 8, Issue:8 Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Carbamates; Cell Membrane Permeability; Cyclosporine; Digoxin; Dogs; Furans; Gene Expression; Humans; Ketoconazole; Kinetics; Loperamide; Madin Darby Canine Kidney Cells; Protein Binding; Quinidine; Sulfonamides; Tetrahydroisoquinolines; Vinblastine	2013
Possible involvement of cationic-drug sensitive transport systems in the blood-to-brain influx and brain-to-blood efflux of amantadine across the blood-brain barrier. Biopharmaceutics & drug disposition, 2015, Volume: 36, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Amantadine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cell Line; Cyclosporine; Ion Pumps; Male; Microinjections; Quinidine; Rats; Rhodamine 123; Tritium; Verapamil	2015
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:5 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cyclosporins; In Vitro Techniques; Intestinal Mucosa; Isoquinolines; Ketoconazole; Male; Quinazolines; Quinidine; Rats, Wistar; Rhodamine 123; Verapamil	2015
Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:7 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Culture Techniques; Cells, Cultured; Cholestasis; Cyclosporine; HEK293 Cells; Hepatocytes; Humans; Multidrug Resistance-Associated Proteins; Propionates; Quinidine; Quinolines; Rats, Sprague-Dawley	2015
Novel in vitro transport method for screening the reversibility of P-glycoprotein inhibitors. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2016, Volume: 100 Topics: ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Caco-2 Cells; Cell Culture Techniques; Cell Survival; Cyclosporine; Drug Evaluation, Preclinical; Humans; Quinidine; Verapamil	2016
Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers. The Journal of pharmacy and pharmacology, 2016, Volume: 68, Issue:7 Topics: Acetic Acid; Aristolochic Acids; ATP-Binding Cassette Transporters; Benzoic Acid; Biological Transport; Caco-2 Cells; Cells, Cultured; Cyclosporine; Diketopiperazines; Heterocyclic Compounds, 4 or More Rings; Humans; Hydrogen-Ion Concentration; Indomethacin; Intestinal Absorption; Mitoxantrone; Pravastatin; Propionates; Quercetin; Quinidine; Quinolines	2016
Development of a cyclosporin A derivative with excellent anti-hepatitis C virus potency. Bioorganic & medicinal chemistry, 2018, 02-15, Volume: 26, Issue:4 Topics: Antiviral Agents; Cyclization; Cyclosporine; Dipeptides; Drug Design; Hepacivirus; Quinidine; Stereoisomerism; Virus Replication	2018