quinazolines has been researched along with zd 9331 in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (25.45) | 18.2507 |
| 2000's | 39 (70.91) | 29.6817 |
| 2010's | 2 (3.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boyle, FT; Brown, M; Brunton, L; Harrap, KR; Jackman, AL; Kimbell, R; Wardleworth, JM | 1 |
| Harrap, KR | 1 |
| Jackman, AL; Kobayashi, H; Miyachi, H; Skelton, L; Takemura, Y | 1 |
| Calvert, AH; Jackman, AL | 1 |
| Takimoto, CH | 1 |
| Kobayashi, H; Miyachi, H; Takemura, Y | 1 |
| Bavetsias, V; Jackman, AL | 1 |
| Aherne, GW; Boyle, FT; Brunton, L; Jackman, AL; Jansen, G; Kimbell, R; Smith, MN; Stephens, TC; Wardleworth, JM | 1 |
| Pazdur, R; Touroutoglou, N | 1 |
| Aherne, GW; Boyle, FT; Jackman, AL; Medlow, CJ; Mitchell, F; Walton, MI | 1 |
| Boyle, FT; Brown, M; Hennequin, LF; Jackman, AL; Kimbell, R; Marsham, PR; Wardleworth, JM | 1 |
| Creutzig, U; Hählen, K; Janka-Schaub, G; Jansen, G; Kaspers, GJ; Mauritz, R; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ; Willey, JC | 1 |
| Newell, DR | 1 |
| Danenberg, PV; Malli, H; Swenson, S | 1 |
| Aherne, GW; Brunton, L; Jackman, AL; Monaghan, P; Titley, J; Valenti, M; Welsh, SJ | 1 |
| Aherne, GW; Hardcastle, A; Jackman, AL; Ladner, RD; Webley, SD | 1 |
| Jackman, AL; Lynn, S; Mitchell, F | 1 |
| Cassidy, J | 1 |
| Averbuch, S; Bertucci, D; Douglass, E; Goh, BC; Hutchison, M; Mani, S; Ratain, MJ; Schilsky, RL; Smith, M; Smith, R; Vogelzang, NJ | 1 |
| Niculescu-Duvaz, I | 1 |
| Aherne, GW; Jackman, AL; Webley, SD; Welsh, SJ | 1 |
| Aherne, GW; Brunton, L; Crompton, T; Dobinson, D; Hardcastle, A; Jackman, AL; Valenti, M; Ward, E | 1 |
| Boyer, J; Ferguson, PR; Harkin, DP; Johnston, PG; Latif, T; Longley, DB; Lynch, M; Maxwell, P | 1 |
| Calvert, AH; Cunningham, D; Farrugia, DC; Ford, HE; Hill, ME; Jackman, AL; Judson, IR; Mitchell, F; Rees, C | 1 |
| Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH | 1 |
| de Jonge, MJ; de Mulder, PH; Jackman, A; Peters, ME; Planting, AS; Punt, CJ; Smith, R; Sparreboom, A; van De Schraaf, J; Verweij, J | 1 |
| Aherne, GW; Brunton, L; Jackman, AL; Kimbell, R; Melin, CJ; Theti, DS; Walton, M | 1 |
| Bonneterre, J; Culine, S; de Jonge, MJ; de Vries, EG; Droz, J; Glimelius, B; Smith, R; Van Groeningen, C; Verweij, J; Young, J | 1 |
| D'Orazio, AI; Gambill, BD | 1 |
| Aherne, GW; Hobbs, S; Welsh, SJ | 1 |
| Bailly, C; Lansiaux, A | 1 |
| Beale, P; Calvert, H; Douglass, E; Gokul, S; Highley, M; Hughes, A; Jackman, A; Judson, I; Mitchell, F; Plummer, R; Rees, C; Smith, R; Trigo, J | 1 |
| Bertucci, D; Douglass, EC; Fleming, GF; Ratain, MJ; Sawyer, MB; Schilsky, RL; Shulman, K; Smith, RP; Vogelzang, NJ | 1 |
| Beale, P; Douglass, E; Jackman, A; Judson, I; Mitchell, F; Rees, C; Smith, R; Trigo, JM | 1 |
| Callender, MA; Chu, E; Farrell, MP; Schmitz, JC | 1 |
| Gallagher, N; Smith, D | 1 |
| Aiba, K; Horikoshi, N; Koizumi, W; Sasaki, T; Sato, A | 1 |
| Petruzelka, L | 1 |
| Hainsworth, J; Janssens, J; Vergote, I | 1 |
| Benson, A; Poplin, E; Vergote, I | 1 |
| Carson, L; Clarke-Pearson, D; Douglass, EC; Holloway, R; Kao, MS; Moore, M; Rader, JS; Wiznitzer, I | 1 |
| Geller, J; Houghton, JA; Nagy, K; Petak, I; Szucs, KS; Tillman, DM | 1 |
| Algazy, K; Bilenker, JH; Flaherty, KT; Garcia-Vargas, JE; Giantonio, BJ; Haller, DG; Koehler, M; McLaughlin, K; O'Dwyer, PJ; Stevenson, JP | 1 |
| Jackman, AL; Theti, DS | 1 |
| Canfield, V; Douglass, E; Keller, A; Parker, G; Schulz, J | 1 |
| Garrison, M; Jones, CB; McCreery, H; Patnaik, A; Rowinsky, EK; Schwartz, GH; Skinner, M; Takimoto, C; Tolcher, AW | 1 |
| Ackland, SP; Beale, P; Peters, GJ | 1 |
| Doyle, B; Geller, JI; Houghton, JA; Petak, I; Szekely-Szucs, K | 1 |
| Goldman, ID; Wang, Y; Zhao, R | 1 |
| Benepal, TS; Judson, I | 1 |
| André, T; de Gramont, A; Gamelin, E; Garcia, ML; Kalla, S; Lenaers, G; Louvet, C; Méry-Mignard, D; Saavedra, A | 1 |
| André, T; Coudray, AM; De Gramont, A; Faivre, S; Gespach, C; Kornprobst, M; Larsen, AK; Louvet, C; Raymond, E; Tournigand, C | 1 |
| Gibson, LM; Lebioda, L; Lovelace, LL | 1 |
| Bielak, M; Celeste, LR; Chai, G; Lebioda, L; Lovelace, LL; Minor, W | 1 |
| Goldman, ID; Visentin, M; Zhao, R | 1 |
15 review(s) available for quinazolines and zd 9331
| Article | Year |
|---|---|
The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.
Topics: Animals; Antineoplastic Agents; Biological Transport; Clinical Trials, Phase II as Topic; Drug Resistance; Humans; Leukemia L1210; Methotrexate; Mice; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1994 |
Initiatives with platinum- and quinazoline-based antitumor molecules--Fourteenth Bruce F. Cain Memorial Award Lecture.
Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Resistance; Female; Humans; Leukemia L1210; Mice; Neoplasm Transplantation; Organoplatinum Compounds; Ovarian Neoplasms; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 1995 |
Folate-based thymidylate synthase inhibitors as anticancer drugs.
Topics: Antineoplastic Agents; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 1995 |
Antifolates in clinical development.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase | 1997 |
Nonpolyglutamatable antifolates as inhibitors of thymidylate synthase (TS) and potential antitumour agents.
Topics: Antimetabolites, Antineoplastic; Cell Division; Excitatory Amino Acid Antagonists; Folic Acid Antagonists; Humans; Indoles; Peptide Synthases; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1998 |
Thymidylate synthase inhibitors.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Enzyme Inhibitors; Genes, p53; Humans; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
Clinical pharmacokinetics of antitumor antifolates.
Topics: Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase | 1999 |
Thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 1999 |
Thymidylate synthase inhibitors in colorectal cancer.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 2000 |
ZD-9331 AstraZeneca.
Topics: Animals; Antineoplastic Agents; Contraindications; Drugs, Investigational; Enzyme Inhibitors; Humans; Neoplasms; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 2000 |
A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours.
Topics: Antineoplastic Agents; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Folic Acid Antagonists; Gene Expression; Humans; Ovarian Neoplasms; Peptide Synthases; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Thymidylate synthase inhibitors as anticancer agents: from bench to bedside.
Topics: Antineoplastic Agents; Enzyme Inhibitors; Humans; Indoles; Isoindoles; Neoplasms; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Thymidylate Synthase | 2003 |
ZD9331 in combination with topotecan: phase I and II experience.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Middle Aged; Neoplasms; Quinazolines; Topotecan | 2003 |
Thymidylate synthase inhibitors.
Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Quinazolines; Thymidylate Synthase | 2003 |
ZD9331: discovery to clinical development.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Neoplasms; Ovarian Neoplasms; Quinazolines; Thymidylate Synthase | 2005 |
17 trial(s) available for quinazolines and zd 9331
| Article | Year |
|---|---|
Phase I study of ZD9331 on short daily intravenous bolus infusion for 5 days every 3 weeks with fixed dosing recommendations.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Neutropenia; Quinazolines; Thrombocytopenia | 2001 |
Patterns of elevation of plasma 2'-deoxyuridine, a surrogate marker of thymidylate synthase (TS) inhibition, after administration of two different schedules of 5-fluorouracil and the specific TS inhibitors raltitrexed (Tomudex) and ZD9331.
Topics: Antimetabolites, Antineoplastic; Biomarkers, Tumor; Colorectal Neoplasms; Deoxyuridine; Enzyme Inhibitors; Fluorouracil; Humans; Infusions, Intravenous; Quinazolines; Thiophenes; Thymidylate Synthase | 2002 |
Phase I and pharmacologic study of oral ZD9331, a novel nonpolyglutamated thymidylate synthase inhibitor, in adult patients with solid tumors.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Area Under Curve; Bone Marrow; Chromatography, Liquid; Drug Eruptions; Female; Humans; Male; Mass Spectrometry; Middle Aged; Neoplasms; Quinazolines; Thymidylate Synthase; Treatment Outcome | 2002 |
Effects of impaired renal function on the pharmacokinetics and toxicity of i.v. ZD9331, a novel non-polyglutamated thymidylate synthase inhibitor, in adult patients with solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Blood Cell Count; Creatinine; Enzyme Inhibitors; Female; Hematologic Diseases; Humans; Injections, Intravenous; Kidney Diseases; Male; Middle Aged; Neoplasms; Quinazolines; Thymidylate Synthase | 2002 |
A phase I trial of ZD9331, a water-soluble, nonpolyglutamatable, thymidylate synthase inhibitor.
Topics: Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Models, Chemical; Neoplasms; Quinazolines; Thymidylate Synthase; Time Factors; Water | 2003 |
Phase I study of an oral formulation of ZD9331 administered daily for 28 days.
Topics: Administration, Oral; Adult; Aged; Anemia; Antineoplastic Agents; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Neutropenia; Quinazolines; Thrombocytopenia | 2003 |
Phase I trial of ZD9331, a nonpolyglutamatable thymidylate synthase inhibitor, given as a 5-day continuous infusion to patients with refractory solid malignancies.
Topics: Adult; Aged; Antineoplastic Agents; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Quinazolines | 2003 |
A phase II/III study comparing intravenous ZD9331 with gemcitabine in patients with pancreatic cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Deoxycytidine; Female; Gemcitabine; Humans; Infusions, Intravenous; Male; Middle Aged; Pancreatic Neoplasms; Quinazolines; Survival Analysis | 2003 |
Phase I dose-escalation trial of ZD9331 in Japanese patients with refractory, solid malignancies.
Topics: Adult; Colorectal Neoplasms; Drug Tolerance; Female; Humans; Japan; Male; Middle Aged; Neoplasms; Quinazolines; Stomach Neoplasms | 2003 |
Phase II multicentre trial of ZD9331 monotherapy as first-line treatment for gastric cancer.
Topics: Abdominal Pain; Antineoplastic Agents; Diarrhea; Drug Tolerance; Hematologic Diseases; Humans; Multicenter Studies as Topic; Neutropenia; Quinazolines; Stomach Neoplasms; Thymidylate Synthase | 2003 |
A review of phase II studies of ZD9331 treatment for relapsed or refractory solid tumours.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Male; Middle Aged; Neoplasms; Ovarian Neoplasms; Quinazolines | 2003 |
ZD9331 in combination with topotecan: phase I and II experience.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Middle Aged; Neoplasms; Quinazolines; Topotecan | 2003 |
A phase II study to determine the efficacy and tolerability of intravenous ZD9331 in heavily pretreated patients with ovarian cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Infusions, Intravenous; Middle Aged; Ovarian Neoplasms; Quinazolines | 2003 |
Phase I trial of the antifolate ZD9331 in combination with cisplatin in patients with refractory solid malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Female; Folic Acid Antagonists; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Quinazolines | 2004 |
ZD9331 as second- or third-line therapy in patients with advanced colorectal cancer: a phase II multicenter trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Male; Middle Aged; Quinazolines | 2004 |
A phase I and pharmacokinetic study of the nonpolyglutamatable thymidylate synthase inhibitor ZD9331 plus docetaxel in patients with advanced solid malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Quinazolines; Taxoids; Thymidylate Synthase; Time Factors; Treatment Outcome | 2004 |
A phase I-II, dose-escalating trial of ZD9331 in combination with irinotecan (CPT11) in previously pretreated metastatic colorectal cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Female; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neutropenia; Quinazolines; Rectal Neoplasms | 2004 |
24 other study(ies) available for quinazolines and zd 9331
| Article | Year |
|---|---|
Effect of hammerhead ribozyme against human thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitors.
Topics: B-Lymphocytes; Base Sequence; Drug Resistance; Drug Synergism; Enzyme Induction; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Molecular Sequence Data; Nucleic Acid Conformation; Quinazolines; Repetitive Sequences, Nucleic Acid; RNA, Catalytic; RNA, Messenger; Thiophenes; Thymidylate Synthase; Transfection; Trimetrexate | 1995 |
Molecular characterization of human acute leukemia cell line resistant to ZD9331, a non-polyglutamatable thymidylate synthase inhibitor.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carrier Proteins; Drug Resistance, Neoplasm; Humans; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Peptide Synthases; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Female; Humans; Kinetics; Leucovorin; Leukemia L1210; Leukemia L5178; Methotrexate; Mice; Mice, Inbred DBA; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1997 |
The renal effects of the water-soluble, non-folylpolyglutamate synthetase-dependent thymidylate synthase inhibitor ZD9331 in mice.
Topics: Animals; Antineoplastic Agents; Female; Glomerular Filtration Rate; Infusions, Intravenous; Injections, Intraperitoneal; Kidney; Mice; Mice, Inbred DBA; Quinazolines; Thymidylate Synthase | 1998 |
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.
Topics: Animals; Antineoplastic Agents; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Leukemia L1210; Mice; Models, Chemical; Quinazolines; Thymidylate Synthase | 1999 |
Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Quinazolines; Thiophenes; Treatment Outcome; Trimetrexate | 1999 |
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Flow Cytometry; Fluorouracil; Glutamates; Guanine; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Mice; Mice, Inbred DBA; Microscopy, Confocal; Neoplasm Transplantation; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured; Up-Regulation | 2000 |
Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331.
Topics: Antineoplastic Agents; Apoptosis; DNA Repair; Humans; Lung Neoplasms; Pyrophosphatases; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
Modified high-performance liquid chromatography assay for the measurement of 2'-deoxyuridine in human plasma and its application to pharmacodynamic studies of antimetabolite drugs.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Deoxyuridine; Folic Acid Antagonists; Humans; Quinazolines; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2000 |
The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Division; Colony-Forming Units Assay; Deoxyuracil Nucleotides; DNA; DNA Damage; Female; Flow Cytometry; Humans; Pyrophosphatases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Thymidylate Synthase; Transfection; Tumor Cells, Cultured | 2001 |
Pharmacokinetic/pharmacodynamic study of ZD9331, a nonpolyglutamatable inhibitor of thymidylate synthase, in a murine model following two curative administration schedules.
Topics: Animals; Antineoplastic Agents; Deoxyribonucleotides; Disease Models, Animal; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Female; Infusion Pumps; Injections, Intraperitoneal; Injections, Subcutaneous; Lymphoma; Mice; Mice, Inbred DBA; Nucleoside-Phosphate Kinase; Quinazolines; Time Factors; Tissue Distribution | 2001 |
Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies.
Topics: Blotting, Northern; Blotting, Western; Camptothecin; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cisplatin; Cyclin A; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Humans; Irinotecan; Neoplasms; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Protein Serine-Threonine Kinases; Quinazolines; RNA, Messenger; Tetracycline; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2001 |
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
25th European Society for Medical Oncology Congress. Hamburg, Germany. October 13-17, 2000.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Quinazolines | 2001 |
Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Survival; Comet Assay; DNA Damage; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Lung Neoplasms; N-Glycosyl Hydrolases; Quinazolines; Thiophenes; Thymidylate Synthase; Transfection; Tumor Cells, Cultured; Uracil-DNA Glycosidase | 2003 |
[Perspectives on the oncologist pharmacopoeia].
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Boronic Acids; Bortezomib; Dioxoles; Indoles; Isoquinolines; Neoplasms; Organoplatinum Compounds; Protease Inhibitors; Pyrazines; Pyrroles; Quinazolines; Sesquiterpenes; Tetrahydroisoquinolines; Trabectedin | 2003 |
Interferon-gamma-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the inhibitor of apoptosis survivin.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Caspase 3; Caspase 7; Caspase 8; Caspases; Caspases, Initiator; Cell Line; Cell Line, Tumor; Colonic Neoplasms; Cysteine Endopeptidases; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; fas Receptor; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Inhibitor of Apoptosis Proteins; Interferon-gamma; Kinetics; Microtubule-Associated Proteins; Mitochondria; Multienzyme Complexes; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Retroviridae; RNA, Small Interfering; Signal Transduction; Survivin; Time Factors; Transfection; Tumor Suppressor Protein p53; Up-Regulation | 2003 |
The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Models, Chemical; Neoplasms; Pemetrexed; Quinazolines; Receptors, Cell Surface; Thiophenes; Time Factors | 2004 |
P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.
Topics: Apoptosis; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Synergism; Enzyme Inhibitors; fas Receptor; G1 Phase; HCT116 Cells; HT29 Cells; Humans; Interferon-gamma; Purines; Quinazolines; Roscovitine; S Phase; Thymidylate Synthase | 2004 |
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Blotting, Northern; Carrier Proteins; Cell Line; Cell Line, Tumor; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Ions; Kinetics; Membrane Transport Proteins; Methotrexate; Pemetrexed; Protein Isoforms; Quinazolines; Receptors, Cell Surface; Reduced Folate Carrier Protein; RNA; Thiophenes; Time Factors; Transfection; Trimetrexate | 2004 |
Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independen
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Camptothecin; Caspase 3; Caspase Inhibitors; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cysteine Proteinase Inhibitors; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; HT29 Cells; Humans; Intracellular Signaling Peptides and Proteins; Irinotecan; Oligopeptides; Organoplatinum Compounds; Oxaliplatin; Pemetrexed; Protein Serine-Threonine Kinases; Quinazolines; rho-Associated Kinases; Thymidylate Synthase; Time Factors; Topoisomerase I Inhibitors | 2005 |
Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors.
Topics: Allosteric Regulation; Animals; Binding Sites; Fluorescence; Humans; Kinetics; Mice; Models, Molecular; Organophosphonates; Phosphates; Pregnadienes; Protein Conformation; Quinazolines; Thymidylate Synthase | 2007 |
Mechanism of N10-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors.
Topics: Antineoplastic Agents; Binding, Competitive; Catalysis; Enzyme Inhibitors; Formate-Tetrahydrofolate Ligase; Kinetics; Ligands; Models, Biological; Models, Molecular; Multiprotein Complexes; Organophosphorus Compounds; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Quinazolines | 2012 |
Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis.
Topics: Cell Line, Tumor; Endocytosis; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Pemetrexed; Proton-Coupled Folate Transporter; Quinazolines; Reduced Folate Carrier Protein; Thiophenes | 2015 |