quinazolines has been researched along with wortmannin in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (9.52) | 18.2507 |
| 2000's | 29 (69.05) | 29.6817 |
| 2010's | 9 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barrington, M; Kotsonis, P; Majewski, H; Murphy, TV | 1 |
| Breu, J; Muchnicki, L; Slack, BE; Wurtman, RJ | 1 |
| Boulton, S; Durkacz, BW; Kyle, S | 1 |
| Mei, L; Si, J | 1 |
| del Carmen Medina, L; García-Sáinz, JA; Vázquez-Prado, J | 1 |
| Balmain, A; Beug, H; Oft, M; Petritsch, C | 1 |
| Adachi, H; Fujioka, T; Kim, JH; Saito, K; Tsujimoto, M; Ui, M; Yokoyama, S | 1 |
| Pouysségur, J; Viñals, F | 1 |
| Eckhart, AD; Eguchi, S; Kim, J; Koch, WJ | 1 |
| Buresi, MC; Buret, AG; Hollenberg, MD; MacNaughton, WK | 1 |
| Hedley, DW; Ng, SS; Nicklee, T; Tsao, MS | 1 |
| Dick, K; Sadhu, C; Staunton, DE; Tino, WT | 1 |
| El-kholy, W; MacDonald, PE; Targonsky, ED; Tsushima, RG; Wang, X; Wheeler, MB; Xia, F | 1 |
| Mattingly, RR; Menard, RE | 1 |
| Barrett, KE; Bertelsen, LS; Keely, SJ | 1 |
| Slomiany, A; Slomiany, BL | 1 |
| Campadelli-Fiume, G; Gianni, T; Menotti, L | 1 |
| Bernd, A; Guschel, M; Kaufmann, R; Kippenberger, S; Knies, Y; Loitsch, S; Müller, J | 1 |
| Ikejima, T; Onodera, S; Tashiro, S; Wang, C; Wang, MW | 1 |
| Catt, KJ; Chu, DB; Neithardt, A; Shah, BH; Shah, FB | 1 |
| Deres, P; Gallyas, F; Hideg, K; Kalai, T; Kovacs, K; Sumegi, B; Toth, A | 1 |
| Cai, K; Enomoto, A; Hosoi, Y; Li, Z; Matsumoto, Y; Miyagawa, K; Morita, A; Nakagawa, K; Tanno, Y | 1 |
| Ashworth, A; Caplin, M; Friedmann, BJ; Hartley, JA; Hochhauser, D; Lord, CJ; Savic, B; Shah, T | 1 |
| Casas-González, P; García-Sáinz, JA | 1 |
| Ferreira, AM; Hayflick, JS; Isaacs, H; Rogers, KA; Sandig, M | 1 |
| Bi, Z; Li, Y; Wan, Y; Yan, B | 1 |
| Kimura, M; Ogihara, M; Okamoto, H | 1 |
| Baker, JE; Fu, X; Gross, GJ; Hsu, A; Strande, JL; Su, J | 1 |
| Bae, YS; Catt, KJ; Choi, H; Hunyady, L; Leto, TL; Rhee, SG | 1 |
| Avissar, NE; Sax, HC; Toia, L | 1 |
| Lin, CC; Lin, WN; Luo, SF; Wu, CB; Yang, CM | 1 |
| Bajer, S; Dudkowska, M; Grzelakowska-Sztabert, B; Jaworski, T; Manteuffel-Cymborowska, M; Zielińska, J | 1 |
| Andina, N; Dahinden, CA; Didichenko, S; Schmidt-Mende, J; Simon, HU | 1 |
| Knight, ZA | 1 |
| Chen, ZC; Guan, YJ; Li, C; Li, MY; Li, XH; Liang, K; Peng, F; Tang, CE; Xiao, ZQ; Yao, KT; Yi, B; Yi, H; Zhang, PF; Zou, HY | 1 |
| Cain, RJ; Ridley, AJ; Vanhaesebroeck, B | 1 |
| Dixon, SJ; Jirik, FR; Kashishian, A; Lannutti, BJ; Pereverzev, A; Puri, KD; Shugg, RP; Sims, SM; Steiner, BH; Tanabe, N; Thomson, A | 1 |
| Fujii, H; Izawa, S; Kiessling, R; Kono, K; Kua, LF; Mimura, K; Mueller, A; Seliger, B; Shiraishi, K; So, J; Yong, WP | 1 |
| Garay, E; García-Carrancá, A; Martínez-Ramírez, AS; Vázquez-Cuevas, FG | 1 |
| Münz, C; Nytko, KJ; Reichenbach, J; Romao, S; Siler, U; Tejera, E | 1 |
| Choi, MG; Ihm, SH; Kang, JG; Kim, CS; Kim, SH; Lee, SJ | 1 |
| Chang, HN; Chueh, HY; Pang, JS; Yeh, YC | 1 |
1 review(s) available for quinazolines and wortmannin
| Article | Year |
|---|---|
Small molecule inhibitors of the PI3-kinase family.
Topics: Adenine; Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Chromones; DNA-Activated Protein Kinase; DNA-Binding Proteins; Humans; Morpholines; Neoplasms; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Tumor Suppressor Proteins; Wortmannin | 2010 |
41 other study(ies) available for quinazolines and wortmannin
| Article | Year |
|---|---|
Noradrenaline release and the effect of endogenous activation of the phospholipase C/protein kinase C signalling pathway in rat atria.
Topics: Androstadienes; Animals; Atrial Function; Diacylglycerol Kinase; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Estrenes; Heart Atria; Male; Norepinephrine; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Kinase C; Pyrrolidinones; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Type C Phospholipases; Wortmannin | 1997 |
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Androstadienes; Aspartic Acid Endopeptidases; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Inositol; Inositol Phosphates; Maleimides; Nitriles; Phosphatidylinositols; Phosphotyrosine; Protein Kinase C; Quinazolines; Tumor Cells, Cultured; Tyrphostins; Wortmannin | 1997 |
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage.
Topics: Androstadienes; Animals; Antineoplastic Agents; Cell Survival; CHO Cells; Cricetinae; Dacarbazine; DNA; DNA Damage; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; DNA, Single-Stranded; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Quinazolines; Temozolomide; Wortmannin | 1999 |
ERK MAP kinase activation is required for acetylcholine receptor inducing activity-induced increase in all five acetylcholine receptor subunit mRNAs as well as synapse-specific expression of acetylcholine receptor epsilon-transgene.
Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Lac Operon; Mice; Muscle Fibers, Skeletal; Phosphatidylinositol 3-Kinases; Quinazolines; Receptors, Cholinergic; RNA, Messenger; Sirolimus; Synapses; Transcription, Genetic; Transgenes; Tyrphostins; Up-Regulation; Wortmannin | 1999 |
Cross-talk between receptors with intrinsic tyrosine kinase activity and alpha1b-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Cell Line; Cell Membrane; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Norepinephrine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; Staurosporine; Time Factors; Transfection; Tyrphostins; Wortmannin | 2000 |
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest.
Topics: Activin Receptors, Type I; Androstadienes; Animals; Cells, Cultured; Chromones; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Fibroblasts; G1 Phase; Morpholines; Mutation; Phosphoprotein Phosphatases; Phosphorylation; Protein Biosynthesis; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Quinazolines; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Ribosomal Protein S6 Kinases; S Phase; Signal Transduction; Sirolimus; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Wortmannin | 2000 |
Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Cell-Free System; CHO Cells; Cricetinae; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Quinazolines; Receptor, Insulin; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Wortmannin | 2001 |
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.
Topics: Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Chromones; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Wortmannin | 2001 |
Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases.
Topics: Androstadienes; Animals; Cells, Cultured; DNA Replication; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibroblasts; Heart; Isoproterenol; Male; Mitogen-Activated Protein Kinases; Myocardium; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Tyrphostins; Virulence Factors, Bordetella; Wortmannin | 2002 |
Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.
Topics: Androstadienes; Butadienes; Cell Line; Chlorides; Epithelial Cells; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Nitriles; Nitrobenzenes; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Pyridines; Pyrimidines; Quinazolines; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Sulfonamides; Thrombin; Tyrphostins; Wortmannin | 2002 |
Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Androstadienes; Animals; Antineoplastic Agents; Apoptosis; Deoxycytidine; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Fluorescent Antibody Technique, Indirect; Gemcitabine; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, SCID; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Wortmannin | 2002 |
Selective role of PI3K delta in neutrophil inflammatory responses.
Topics: Adenine; Androstadienes; Animals; Anti-Inflammatory Agents; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exocytosis; Inflammation; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Morpholines; Neutrophils; Phosphatidylinositol 3-Kinases; Protein Isoforms; Quinazolines; Signal Transduction; Superoxides; Time Factors; Wortmannin | 2003 |
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.
Topics: Androstadienes; Animals; Blotting, Western; Catalysis; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Kinetics; Male; Mice; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Potassium; Precipitin Tests; Protein Precursors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Time Factors; Transcriptional Activation; Tyrphostins; Up-Regulation; Venoms; Wortmannin | 2003 |
Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.
Topics: Androstadienes; Animals; Carbachol; cdc42 GTP-Binding Protein; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Kinetics; Lysophospholipids; Maleimides; Mice; Models, Biological; Myelin Basic Protein; NIH 3T3 Cells; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Quinazolines; rac GTP-Binding Proteins; ras Proteins; Receptor, Muscarinic M2; Receptors, Cell Surface; rho GTP-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrphostins; Wortmannin | 2003 |
Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.
Topics: Androstadienes; Blotting, Western; Cell Line; Chlorides; Chlorine; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; GTP-Binding Protein alpha Subunits, Gs; Humans; Ions; Isoquinolines; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Quinazolines; Sulfonamides; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin | 2004 |
Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Androstadienes; Animals; Bucladesine; Choline; Colforsin; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Isoproterenol; Phosphoinositide-3 Kinase Inhibitors; Phospholipids; Pyrimidines; Quinazolines; Rats; Receptors, Adrenergic, beta; Saliva; src-Family Kinases; Sublingual Gland; Transcriptional Activation; Wortmannin | 2004 |
Entry of herpes simplex virus mediated by chimeric forms of nectin1 retargeted to endosomes or to lipid rafts occurs through acidic endosomes.
Topics: Ammonium Chloride; Androstadienes; Animals; Cell Adhesion Molecules; Cricetinae; Endocytosis; Endosomes; ErbB Receptors; Macrolides; Membrane Fusion; Membrane Microdomains; Nectins; Quinazolines; Receptors, Virus; Simplexvirus; Tyrphostins; Wortmannin | 2004 |
Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor.
Topics: Androstadienes; Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Line; Cell Membrane; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermis; Epithelial Cells; ErbB Receptors; Genes, Dominant; Humans; Immunoblotting; Microscopy, Confocal; Morpholines; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, Angiotensin, Type 1; Signal Transduction; Threonine; Time Factors; Tyrphostins; Wortmannin | 2005 |
Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death.
Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Enzyme Inhibitors; Evodia; Gene Expression; Genes, p53; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; MAP Kinase Signaling System; Melanoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phytotherapy; Plant Extracts; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Sirtuin 1; Sirtuins; Staurosporine; Wortmannin | 2005 |
Role of EGF receptor transactivation in phosphoinositide 3-kinase-dependent activation of MAP kinase by GPCRs.
Topics: Androstadienes; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 2; Gonadotropin-Releasing Hormone; Hepatocytes; Humans; Kidney; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphatidylinositol 3-Kinases; Protein Kinase C; Quinazolines; ras Proteins; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Tyrphostins; Wortmannin | 2006 |
Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion.
Topics: Androstadienes; Animals; Benzimidazoles; Blotting, Western; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart; In Vitro Techniques; Lipid Peroxidation; Male; Morpholines; Myocardial Reperfusion Injury; Perfusion; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Ventricular Function, Left; Wortmannin | 2006 |
Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.
Topics: Androstadienes; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Infrared Rays; Intracellular Signaling Peptides and Proteins; Kinetics; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; Radiation, Ionizing; Signal Transduction; src-Family Kinases; Temperature; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Wortmannin; X-Rays | 2006 |
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Topics: Androstadienes; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Nucleus; Cisplatin; Cytosol; DNA; DNA-Activated Protein Kinase; ErbB Receptors; Etoposide; Gefitinib; Humans; Neoplasms; Protein Kinase Inhibitors; Quinazolines; Rats; RNA, Small Interfering; Wortmannin | 2006 |
Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.
Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Antibodies; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Endothelin-1; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Norepinephrine; Phenylalanine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Thiophenes; Tyrphostins; Wortmannin | 2006 |
The p110delta isoform of PI3K differentially regulates beta1 and beta2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis.
Topics: Adenine; Androstadienes; CD18 Antigens; cdc42 GTP-Binding Protein; Cell Line; Cell Movement; Chromones; Class I Phosphatidylinositol 3-Kinases; Gene Expression Regulation; Humans; Integrin alpha4beta1; Integrin beta1; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; rac1 GTP-Binding Protein; Signal Transduction; Vascular Cell Adhesion Molecule-1; Wortmannin | 2006 |
UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway.
Topics: Androstadienes; Blotting, Western; Cell Line; Chromones; Dose-Response Relationship, Radiation; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Keratinocytes; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Tumor Suppressor Proteins; Ultraviolet Rays; Vascular Endothelial Growth Factor A; Wortmannin | 2006 |
Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Hepatocytes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Biological; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Sphingosine; Tyrphostins; Wortmannin | 2007 |
SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts.
Topics: Androstadienes; Animals; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hirudins; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channel Blockers; Potassium Channels; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Recombinant Proteins; Research Design; RNA, Messenger; Signal Transduction; Thrombin; Time Factors; Ventricular Function, Left; Wortmannin | 2007 |
Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Angiotensin II; Animals; Cell Line; CHO Cells; Chromones; Cricetinae; Cricetulus; Gene Expression; Humans; Indoles; Maleimides; Membrane Glycoproteins; Morpholines; Mutation; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Kinase C; Pyrazoles; Pyrimidines; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Superoxides; Tyrphostins; Wortmannin | 2008 |
In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.
Topics: Amino Acid Transport System ASC; Androstadienes; Blotting, Western; Caco-2 Cells; Cell Membrane; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamine; Humans; Minor Histocompatibility Antigens; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; rho GTP-Binding Proteins; RNA Interference; Signal Transduction; Sodium; Time Factors; Tyrphostins; Up-Regulation; Wortmannin | 2008 |
Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.
Topics: Androstadienes; Blotting, Western; Cell Adhesion; Cell Line; Chromones; Dose-Response Relationship, Drug; E1A-Associated p300 Protein; ErbB Receptors; Humans; Lipopolysaccharides; Morpholines; Myocytes, Smooth Muscle; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Trachea; Transfection; Tyrphostins; Vascular Cell Adhesion Molecule-1; Wortmannin | 2008 |
Antifolate/folate-activated HGF/c-Met signalling pathways in mouse kidneys-the putative role of their downstream effectors in cross-talk with androgen receptor.
Topics: Androstadienes; Animals; Cyclin D2; Cyclins; Female; Folic Acid; Folic Acid Antagonists; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hepatocyte Growth Factor; Kidney; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Ornithine Decarboxylase; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; PTEN Phosphohydrolase; Quinazolines; Receptor Cross-Talk; Receptors, Androgen; Signal Transduction; Testosterone; Wortmannin | 2009 |
Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.
Topics: Adenine; Androstadienes; Apoptosis; Cells, Cultured; Chromones; Eosinophils; Humans; Hypersensitivity; Interleukin-5; Janus Kinase 2; Microscopy, Confocal; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-pim-1; Quinazolines; Tyrphostins; Wortmannin; Xanthenes | 2009 |
Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics.
Topics: Amyloid beta-Protein Precursor; Androstadienes; Antibodies, Monoclonal; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cystatin C; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; ErbB Receptors; Humans; Immunohistochemistry; Nasopharyngeal Neoplasms; Proteomics; Quinazolines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transforming Growth Factor alpha; Wortmannin | 2010 |
Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration.
Topics: Adenine; Androstadienes; Antigens, CD; Cadherins; Capillary Permeability; Cell Membrane Permeability; Cell Shape; Class Ia Phosphatidylinositol 3-Kinase; Dioxoles; Endothelial Cells; Focal Adhesion Kinase 2; Furans; Human Umbilical Vein Endothelial Cells; Humans; Leukocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Quinazolines; Signal Transduction; Thiazolidinediones; TOR Serine-Threonine Kinases; Transendothelial and Transepithelial Migration; Tumor Necrosis Factor-alpha; Wortmannin | 2012 |
Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption.
Topics: Adenine; Androstadienes; Animals; Bone Resorption; Cell Survival; Chromones; Cytoskeleton; Indazoles; Isoenzymes; Morpholines; Osteoclasts; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; Rabbits; RANK Ligand; Rats; Sulfonamides; Wortmannin | 2013 |
The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.
Topics: Androstadienes; Antigen Presentation; Antigens, Neoplasm; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, MHC Class I; HLA-A Antigens; Humans; Lapatinib; MAP Kinase Signaling System; Neoplasm Proteins; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; RNA, Small Interfering; Signal Transduction; Stomach Neoplasms; Wortmannin | 2013 |
The P2RY2 Receptor Induces Carcinoma Cell Migration and EMT Through Cross-Talk With Epidermal Growth Factor Receptor.
Topics: Androstadienes; Cadherins; Cell Line, Tumor; Cell Movement; Epithelial Cells; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovary; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Receptor Cross-Talk; Receptors, Purinergic P2Y2; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Tyrphostins; Uridine Triphosphate; Vimentin; Wortmannin | 2016 |
Defective nuclear entry of hydrolases prevents neutrophil extracellular trap formation in patients with chronic granulomatous disease.
Topics: Adenine; Androstadienes; Benzylamines; Candida albicans; Cell Nucleus; Extracellular Traps; Granulomatous Disease, Chronic; Histones; Humans; Hydrolases; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Wortmannin | 2015 |
Evodiamine Suppresses Survival, Proliferation, Migration and Epithelial-Mesenchymal Transition of Thyroid Carcinoma Cells.
Topics: Androstadienes; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Synergism; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Thyroid Neoplasms; Wortmannin | 2018 |
The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells.
Topics: Angiogenesis Inhibitors; Apelin; Apelin Receptors; Flavonoids; Gene Expression Regulation; Half-Life; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Signaling Peptides and Proteins; Promoter Regions, Genetic; Quinazolines; RNA Stability; RNA, Messenger; Signal Transduction; Wortmannin | 2019 |