quinazolines has been researched along with whi p154 in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 15 (48.39) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, XP; Myers, DE; Narla, RK; Uckun, FM | 1 |
| Klis, D; Liu, XP; Narla, RK; Uckun, FM | 1 |
| Malaviya, R; Uckun, FM | 1 |
| Ghosh, S; Liu, XP; Mahajan, S; Mao, C; Narla, RK; Sudbeck, EA; Uckun, FM | 1 |
| Ghosh, S; Jun, X; Mahajan, S; Mao, C; Sudbeck, EA; Uckun, FM; Zheng, Y | 1 |
| Ghosh, S; Liu, XP; Myers, DE; Sudbeck, EA; Uckun, FM; Zheng, Y | 1 |
| Frost, RA; Lang, CH; Nystrom, GJ | 1 |
| Malaviya, R; Navara, C; Uckun, FM | 1 |
| Böhmig, G; Kelemen, P; Säemann, MD; Staffler, G; Zeyda, M; Zlabinger, GJ | 1 |
| Burnside, J; Kampa, D | 1 |
| Baumruker, T; Böhmig, GA; Diakos, C; Kelemen, P; Parolini, O; Prieschl, EE; Säemann, MD; Stockinger, H; Stulnig, TM; Szekeres, A; Zeyda, M; Zlabinger, GJ | 1 |
| Brake, DK; Deszo, EL; Freund, GG; Kelley, KW | 1 |
| Amin, HM; Cho-Vega, JH; Gilles, F; Goy, AH; Medeiros, LJ; Rassidakis, GZ; Remache, YK; Spurgers, K; Tsioli, P; Vega, F | 1 |
| Aoyama, S; Hamada, H; Hirasawa, N; Linwong, W; Ohuchi, K; Saito, T | 1 |
| Kasprzycka, M; Marzec, M; Odum, N; Ptasznik, A; Wasik, MA; Wlodarski, P; Zhang, Q | 1 |
| Bootman, MD; Cuddon, P; Kerby, J; Leveridge, M; Ma, QP; Richards, GR; Roderick, HL; Simpson, PB; Smith, AJ | 1 |
| Kankaanranta, H; Kärpänniemi, O; Korhonen, R; Moilanen, E; Nieminen, R; Sareila, O | 2 |
| Bucki, R; El-Salem, M; Halasa, K; Kasprzycka, M; Liu, X; Marzec, M; Raghunath, PN; Wasik, MA; Wlodarski, P | 1 |
| Changelian, PS; Doty, JL; Flanagan, ME; Harris, TM; Kent, CR; Kudlacz, EM; Kuhn, CF; Magnuson, KS; Moshinsky, D; Munchhof, MJ; Perregaux, DG; Sawyer, PS; Sun, J; Whipple, DA | 1 |
| Baik, EJ; Chung, JI; Jung, YS; Kim, YH; Lee, SH; Moon, CH; Suh-Kim, H; Woo, HG | 1 |
| Bhavsar, SK; Bobbala, D; Gu, S; Lang, F | 1 |
| Jou, YS; Ko, JY; Lin, KT; Lin, SC; Tu, PH; Wang, YW | 1 |
| Baik, EJ; Jang, YN; Lee, IJ; Park, MC | 1 |
| Bhavsar, SK; Dong, L; Hosseinzadeh, Z; Lang, F; Pakladok, T; Shumilina, E; Umbach, AT; Warsi, J | 1 |
| Ambudkar, SV; Chen, ZS; Fu, LW; Kathawala, RJ; Patel, A; Sodani, K; Talele, TT; Wang, YJ; Zhang, H; Zhang, YK; Zhu, H | 1 |
| Bhavsar, S; Honisch, S; Hosseinzadeh, Z; Jilani, K; Lang, F; Palmada, M; Schmid, E; Shumilina, E; Singh, Y; Szteyn, K; Umbach, AT | 1 |
| Fuchs, J; Honisch, S; Hosseinzadeh, Z; Lang, F; Schmid, E; Shumilina, E; Yan, J | 1 |
| Fezai, M; Lang, F; Warsi, J | 1 |
| Hosseinzadeh, Z; Lang, F; Yan, J; Zhang, B | 1 |
| Bhavsar, SK; Hosseinzadeh, Z; Khairnar, V; Koepsell, H; Lang, F; Lang, KS; Lang, PA; Palmada, M; Sabolic, I; Sharma, P; Singh, Y; Zhang, S | 1 |
1 review(s) available for quinazolines and whi p154
| Article | Year |
|---|---|
Tyrosine kinase inhibitors against EGF receptor-positive malignancies.
Topics: Adenocarcinoma; Amides; Aniline Compounds; Animals; Antineoplastic Agents; Breast Neoplasms; Drug Design; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Genistein; Humans; Leukemia; Macaca fascicularis; Mice; Mice, Inbred BALB C; Mice, SCID; Models, Molecular; Molecular Structure; Neoplasm Proteins; Neoplasms; Nitriles; Protein Conformation; Protein Structure, Tertiary; Quinazolines; Recombinant Fusion Proteins; Sequence Alignment; Species Specificity; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2001 |
30 other study(ies) available for quinazolines and whi p154
| Article | Year |
|---|---|
4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Dose-Response Relationship, Drug; Epidermal Growth Factor; Glioblastoma; Humans; Mice; Mice, SCID; Quinazolines; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154).
Topics: Actins; Antineoplastic Agents; Cell Adhesion; Epidermal Growth Factor; Glioblastoma; Humans; Integrins; Neoplasm Invasiveness; Quinazolines; Tumor Cells, Cultured | 1998 |
Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions.
Topics: Animals; Bone Marrow Cells; Cell Degranulation; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Dinitrophenols; Gene Deletion; Histamine; Hypersensitivity; Immunoglobulin E; Janus Kinase 3; Leukotriene C4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Protein-Tyrosine Kinases; Quinazolines; Receptor Aggregation; Receptors, IgE; Stem Cell Factor | 1999 |
Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.
Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Computer Simulation; Drug Design; Drug Evaluation, Preclinical; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Leukemia; Models, Molecular; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinazolines; Substrate Specificity; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
Specificity of alpha-cyano-beta-hydroxy-beta-methyl-n-[4-(trifluoromethoxy)phe nyl]-propenamide as an inhibitor of the epidermal growth factor receptor tyrosine kinase.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; COS Cells; Enzyme Inhibitors; ErbB Receptors; Humans; Models, Molecular; Nitriles; Protein Structure, Secondary; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Tumor Cells, Cultured | 1999 |
Regulation of IGF-I mRNA and signal transducers and activators of transcription-3 and -5 (Stat-3 and -5) by GH in C2C12 myoblasts.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Janus Kinase 3; Mice; Milk Proteins; Muscle, Skeletal; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Quinazolines; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Transcriptional Activation | 2002 |
Augmentation of mast cell bactericidal activity by the anti-leukemic drug, 4-(3'bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline.
Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Drug Evaluation, Preclinical; Escherichia coli; Escherichia coli Infections; Male; Mast Cells; Mice; Mice, Inbred BALB C; Peritonitis; Phagocytosis; Quinazolines; Specific Pathogen-Free Organisms | 2002 |
CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when JAK3 activity is inhibited.
Topics: Antigens, CD; CD40 Antigens; Dendritic Cells; Enzyme Inhibitors; Flow Cytometry; Humans; Immune Tolerance; Janus Kinase 3; Monocytes; Protein-Tyrosine Kinases; Quinazolines | 2002 |
Jak3-regulated genes: DNA array analysis of concanavalin a-interleukin-2-activated chicken T cells treated with a specific jak3 inhibitor.
Topics: Animals; Cells, Cultured; Chickens; Concanavalin A; DNA, Complementary; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation; Gene Library; Interleukin-2; Janus Kinase 3; Lymphocyte Activation; Oligonucleotide Array Sequence Analysis; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Quinazolines; Recombinant Proteins; Signal Transduction; T-Lymphocytes | 2002 |
Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154.
Topics: Alkaline Phosphatase; Cell Aggregation; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression; Graft Rejection; Humans; Interleukin-2; Janus Kinase 3; Jurkat Cells; Lymphocyte Activation; NFATC Transcription Factors; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Quinazolines; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Transcription Factors; Transcription, Genetic; Tyrosine | 2003 |
IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta.
Topics: Acetophenones; Antigens, CD; B7-2 Antigen; Benzopyrans; CD11b Antigen; Cell Differentiation; Cell Nucleus; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-4; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Monocytes; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Quinazolines | 2004 |
Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma.
Topics: Alternative Splicing; Anaplastic Lymphoma Kinase; DNA-Binding Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoprecipitation; Janus Kinase 3; Lymphoma, Large-Cell, Anaplastic; Mutation; Oligonucleotide Array Sequence Analysis; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor Protein-Tyrosine Kinases; Repressor Proteins; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors; Tumor Cells, Cultured | 2004 |
Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Degranulation; Cell Line, Tumor; Dinitrophenols; Hexosaminidases; Immunoglobulin E; Janus Kinase 3; Mast Cells; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-vav; Quinazolines; Rats; Serum Albumin; src-Family Kinases | 2005 |
Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.
Topics: Anaplastic Lymphoma Kinase; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Janus Kinase 3; Lymphoma, T-Cell; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor Protein-Tyrosine Kinases; STAT3 Transcription Factor | 2005 |
The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells.
Topics: Calcium; Calcium Signaling; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Humans; Janus Kinase 3; Neurites; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinazolines; Stem Cell Transplantation; Stem Cells; Tetanus Toxin; Tubulin | 2006 |
JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages.
Topics: Animals; Blotting, Western; Cell Nucleus; Enzyme Inhibitors; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Janus Kinase 1; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Polymerase Chain Reaction; Quinazolines; Tyrphostins | 2006 |
Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.
Topics: Anaplastic Lymphoma Kinase; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Humans; Immunohistochemistry; Lymphoma, T-Cell; Mitogen-Activated Protein Kinases; Models, Biological; Nuclear Proteins; Nucleophosmin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor Protein-Tyrosine Kinases; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transfection | 2007 |
Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha.
Topics: Cell Line; Cyclooxygenase 2; Down-Regulation; Humans; Interferon-gamma; Janus Kinase 3; Lipopolysaccharides; Macrophage Activation; Macrophages; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Kinase Inhibitors; Quinazolines; STAT1 Transcription Factor; Tumor Necrosis Factor-alpha | 2008 |
The specificity of JAK3 kinase inhibitors.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Enzyme Inhibitors; Graft Rejection; Humans; Janus Kinase 3; Kinetics; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines | 2008 |
Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway.
Topics: Animals; Blotting, Western; Brain; Cell Differentiation; Cell Proliferation; Cells, Cultured; Immunohistochemistry; Janus Kinase 2; Janus Kinase 3; Mice; Neurogenesis; Neurons; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Stem Cells; Tyrphostins | 2010 |
Janus kinase 3 is expressed in erythrocytes, phosphorylated upon energy depletion and involved in the regulation of suicidal erythrocyte death.
Topics: Adenosine Triphosphate; Animals; Annexin A5; Cell Death; Cell Size; Erythrocyte Count; Erythrocytes; Female; Flow Cytometry; Gene Deletion; Glucose; Humans; Immunohistochemistry; Janus Kinase 3; Male; Mice; Mice, Knockout; Microscopy, Confocal; Phosphatidylserines; Phosphorylation; Protein Kinase Inhibitors; Quinazolines | 2011 |
Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Anaplastic Lymphoma Kinase; Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplasm Metastasis; Phosphorylation; Point Mutation; Protein Kinase Inhibitors; Quinazolines; Receptor Protein-Tyrosine Kinases; Signal Transduction | 2011 |
Role of JAK3 in myogenic differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Insulin-Like Growth Factor II; Janus Kinase 3; MAP Kinase Signaling System; Mice; Myoblasts; MyoD Protein; Myogenic Regulatory Factors; Myogenin; Myosin Heavy Chains; Quinazolines; RNA Interference; RNA, Small Interfering; STAT1 Transcription Factor; STAT3 Transcription Factor | 2012 |
Effect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2.
Topics: Animals; Female; Gene Expression; Humans; Janus Kinase 3; Male; Mice; Mice, Knockout; Oocytes; Peptide Transporter 1; Protein Kinase Inhibitors; Quinazolines; Symporters; Xenopus | 2013 |
WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Antibody Technique; Humans; Lung Neoplasms; Multidrug Resistance-Associated Protein 2; Neoplasm Proteins; Quinazolines | 2014 |
The Role of Janus Kinase 3 in the Regulation of Na⁺/K⁺ ATPase under Energy Depletion.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Cells, Cultured; Dendritic Cells; Energy Metabolism; Female; Gene Deletion; Janus Kinase 3; Male; Mice; Mutation; Oocytes; Quinazolines; Sodium-Potassium-Exchanging ATPase; Xenopus | 2015 |
Impact of Janus Kinase 3 on Cellular Ca Release, Store Operated Ca(2+) Entry and Na(+)/Ca(2+) Exchanger Activity in Dendritic Cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Chemokine CXCL12; Dendritic Cells; Enzyme Inhibitors; Female; Janus Kinase 3; Male; Mice; Quinazolines; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium-Calcium Exchanger; Thapsigargin | 2015 |
Regulation of the Na+,Cl- Coupled Creatine Transporter CreaT (SLC6A8) by the Janus Kinase JAK3.
Topics: Animals; Creatine; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Janus Kinase 3; Membrane Potentials; Membrane Transport Proteins; Mutation; Oocytes; Quinazolines; Xenopus laevis | 2015 |
Down-Regulation of Store-Operated Ca2+ Entry and Na+ Ca2+ Exchange in MCF-7 Breast Cancer Cells by Pharmacological JAK3 Inhibition.
Topics: Adenosine Triphosphate; Breast Neoplasms; Calcium; Down-Regulation; Female; Fura-2; Humans; Janus Kinase 3; MCF-7 Cells; ORAI1 Protein; Quinazolines; Real-Time Polymerase Chain Reaction; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium-Calcium Exchanger; Spectrometry, Fluorescence; TATA-Box Binding Protein; Thapsigargin | 2016 |
Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Biological Transport; Brefeldin A; Caco-2 Cells; Deoxyglucose; Gene Expression Regulation; Glucose; Humans; Janus Kinase 3; Jurkat Cells; Lymphocyte Activation; Mice; Oocytes; Patch-Clamp Techniques; Phlorhizin; Primary Cell Culture; Quinazolines; Signal Transduction; Sodium-Glucose Transporter 1; Spleen; T-Lymphocytes, Cytotoxic; Transgenes; Xenopus laevis | 2016 |