Compounds > quinazolines
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quinazolines and vx680

quinazolines has been researched along with vx680 in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (46.15)29.6817
2010's7 (53.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Doggrell, SA1
Date, DA; Kaur, H; Stiff, AC; Taylor, WR1
Hampton, T1
Albert, DH; Anderson, MG; Bouska, JJ; Donawho, CK; Glaser, KB; Guo, J; Li, J; Niquette, A; Palma, JP; Rodriguez, LE; Semizarov, D; Shah, OJ; Tapang, P; Wang, G1
Dreier, MR; Grabovich, AZ; Katusin, JD; Taylor, WR1
Adams, J; Anderson, K; Copeland, RA; Dhanak, D; Hardwicke, MA; Lai, Z; McDonald, OB; Nartey, EN; Newlander, K; Patrick, D; Stuart, JD; Tummino, PJ; Yang, J1
Bak, A; Bush, TL; Cee, VJ; Chung, G; Deak, HL; Dussault, I; Eden, P; Geuns-Meyer, S; Hodous, BL; Kendall, RL; McElroy, P; Nguyen, HN; Olivieri, PR; Patel, VF; Payton, M; Radinsky, R; Romero, K; Ross, S; Schenkel, LB; Stanton, M; Ziegler, B1
Easthope, E; Emery, A; Glover, DM; Jones, DO; Lawrence, S; Scaerou, F; Sorrell, DA; Stockdale, M; Zheleva, D1
Deng, X; Gray, N; Huang, HC; Kwiatkowski, N; Mitchison, T; Musacchio, A; Santaguida, S; Tan, L; Villa, F; Wang, J1
Chen, JJ; Fang, ZG; Lin, DJ; Liu, LL; Liu, Q; Long, ZJ; Wang, LX; Wang, SW; Xu, DF; Yan, M; Zheng, FM1
Fanelli, M; Hattinger, CM; Landuzzi, L; Magagnoli, G; Michelacci, F; Picci, P; Sero, V; Serra, M; Tavanti, E; Vella, S; Versteeg, R1
Eastmond, DA; Gollapudi, P; Hasegawa, LS1
Bastida, CC; Falchook, GS; Kurzrock, R1

Reviews

2 review(s) available for quinazolines and vx680

ArticleYear
Dawn of Aurora kinase inhibitors as anticancer drugs.
    Expert opinion on investigational drugs, 2004, Volume: 13, Issue:9

    Topics: Animals; Antineoplastic Agents; Aurora Kinase A; Aurora Kinases; Benzamides; Enzyme Inhibitors; Humans; Indoles; Molecular Structure; Piperazines; Protein Serine-Threonine Kinases; Quinazolines; Sulfonamides

2004
Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress.
    Seminars in oncology, 2015, Volume: 42, Issue:6

    Topics: Antineoplastic Agents; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Benzamides; Benzazepines; Benzimidazoles; Clinical Trials as Topic; Heterocyclic Compounds, 3-Ring; Humans; Molecular Targeted Therapy; Neoplasms; Norbornanes; Organophosphates; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Quinazolines; Urea

2015

Other Studies

11 other study(ies) available for quinazolines and vx680

ArticleYear
Analysis of mitotic phosphorylation of borealin.
    BMC cell biology, 2007, Jan-22, Volume: 8

    Topics: Amino Acid Substitution; Aurora Kinase B; Aurora Kinases; Benzamides; CDC2 Protein Kinase; Cell Cycle Proteins; Centromere; Chromosomal Proteins, Non-Histone; Chromosome Segregation; Consensus Sequence; Cycloheximide; G2 Phase; HeLa Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Inhibitor of Apoptosis Proteins; Interphase; Metaphase; Microtubule-Associated Proteins; Mitosis; Multiprotein Complexes; Mutagenesis, Site-Directed; Mutation, Missense; Neoplasm Proteins; Nocodazole; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Piperazines; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Quinazolines; Recombinant Fusion Proteins; Sodium Fluoride; Spindle Apparatus; Substrate Specificity; Survivin; Transfection

2007
New blood cancer therapies under study.
    JAMA, 2007, Feb-07, Volume: 297, Issue:5

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Aurora Kinases; ErbB Receptors; Erlotinib Hydrochloride; Hematologic Neoplasms; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Myelodysplastic Syndromes; Piperazines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Rituximab

2007
Identification of genes that confer tumor cell resistance to the aurora B kinase inhibitor, AZD1152.
    The pharmacogenomics journal, 2009, Volume: 9, Issue:2

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Aurora Kinase B; Aurora Kinases; Cell Line, Tumor; Cell Survival; Comparative Genomic Hybridization; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Mice; Mice, SCID; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Organophosphates; Piperazines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; RNA Interference; RNA, Small Interfering; Time Factors; Up-Regulation; Xenograft Model Antitumor Assays

2009
Short and long-term tumor cell responses to Aurora kinase inhibitors.
    Experimental cell research, 2009, Apr-15, Volume: 315, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Aurora Kinases; Benzamides; Cell Cycle; Cell Line, Tumor; DNA Damage; Enzyme Inhibitors; Etoposide; Histones; Humans; Piperazines; Protein Serine-Threonine Kinases; Quinazolines; Tumor Suppressor Protein p53

2009
Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time1.
    The Biochemical journal, 2009, May-13, Volume: 420, Issue:2

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Aurora Kinase B; Aurora Kinase C; Aurora Kinases; Chromosomal Proteins, Non-Histone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Kinetics; Molecular Sequence Data; Organophosphates; Piperazines; Protein Serine-Threonine Kinases; Quinazolines

2009
Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.
    Cancer research, 2010, Dec-01, Volume: 70, Issue:23

    Topics: Adult; Animals; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Benzamides; Cell Line, Tumor; Cell Proliferation; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; HCT116 Cells; HeLa Cells; Histones; Humans; Mice; Mice, Nude; Mutation; Neoplasms; Organophosphates; Paclitaxel; Phosphorylation; Phthalazines; Piperazines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Quinazolines; Xenograft Model Antitumor Assays

2010
A novel cell-based, high-content assay for phosphorylation of Lats2 by Aurora A.
    Journal of biomolecular screening, 2011, Volume: 16, Issue:8

    Topics: Antibodies, Phospho-Specific; Antineoplastic Agents; Aurora Kinases; Automation, Laboratory; Centrosome; Female; HeLa Cells; High-Throughput Screening Assays; Humans; Microtubule-Associated Proteins; Mitosis; Molecular Imaging; Organophosphates; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Small Molecule Libraries; Tumor Suppressor Proteins; Uterine Cervical Neoplasms

2011
Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen.
    ACS chemical biology, 2012, Jan-20, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aurora Kinase B; Aurora Kinases; Benzazepines; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Isoenzymes; M Phase Cell Cycle Checkpoints; Models, Molecular; Organophosphates; Paclitaxel; Piperazines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Quinazolines; Structure-Activity Relationship; Xenopus laevis

2012
Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism.
    Molecular cancer research : MCR, 2013, Volume: 11, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Aurora Kinases; Benzamides; Cell Line, Tumor; Deoxyglucose; Gene Expression Regulation, Neoplastic; Glucose; Glycolysis; HL-60 Cells; Humans; Indoles; Lactic Acid; Leukemia, Myeloid, Acute; Piperazines; Polyploidy; Purines; Quinazolines; Sequestosome-1 Protein; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; U937 Cells

2013
Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma.
    British journal of cancer, 2013, Nov-12, Volume: 109, Issue:10

    Topics: Adult; Antineoplastic Agents; Aurora Kinases; Benzamides; Bone Neoplasms; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Humans; Molecular Targeted Therapy; Osteosarcoma; Piperazines; Protein Kinase Inhibitors; Quinazolines; Tumor Cells, Cultured; Young Adult

2013
A comparative study of the aneugenic and polyploidy-inducing effects of fisetin and two model Aurora kinase inhibitors.
    Mutation research. Genetic toxicology and environmental mutagenesis, 2014, Volume: 767

    Topics: Aurora Kinase B; Benzamides; Cell Line; Chromosomes, Human; Flavonoids; Flavonols; Humans; Micronuclei, Chromosome-Defective; Piperazines; Polyploidy; Protein Kinase Inhibitors; Quinazolines

2014