Page last updated: 2024-08-21

quinazolines and urea

quinazolines has been researched along with urea in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (17.02)	18.7374
1990's	3 (6.38)	18.2507
2000's	9 (19.15)	29.6817
2010's	24 (51.06)	24.3611
2020's	3 (6.38)	2.80

Authors

Authors	Studies
Lubbe, WF	1
Buschauer, A; Büyüktimkin, S; Schunack, W	1
Bensted, JP; Calvert, AH; Clinton, S; Hughes, LR; Jodrell, DI; Morgan, SE; Newell, DR	1
Huang, HS; Liu, KC	1
Bernier, JL; Lespagnol, A; Lespagnol, C	1
Hishida, S; Mizoi, Y; Tanabe, T; Ueda, M	1
Lowenthal, DT; Shear, L	1
Corvera, S; García-Sáinz, JA; Pushpendran, CK	1
Morgan, TO; Myers, JB; Walker, JN	1
Backman-Gullers, B; Kågedal, B; Lundquist, P; Nilsson, L; Rosling, H	1
WALES, JK	1
Di Padova, F; Heng, R; Schlapbach, A	1
Bayburt, EK; Didomenico, S; Drizin, I; Faltynek, CR; Gomtsyan, A; Hannick, SM; Honore, P; Jarvis, MF; Jinkerson, T; Koenig, JR; Lee, CH; Macri, BS; Marsh, KC; McDonald, HA; Oie, T; Perner, RJ; Schmidt, RG; Stewart, KD; Surowy, CS; Turner, S; Wetter, J; Wismer, CT; Zheng, GZ	1
Chicoine, LG; English, BK; Liu, Y; Nelin, LD; Reber, KM; Young, TL	1
Laufer, S; Wagner, G	1
Cortés, D; Díaz-Cruz, A; Guinzberg, R; Piña, E; Riveros-Rosas, H; Villalobos-Molina, R	1
Bakthavatchalam, R; Blum, CA; Blurton, P; Brian Jones, A; Brielmann, H; Burkamp, F; Chandrasekhar, J; Clarkson, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Hutchison, A; Zheng, X	1
Teng, CM; Wu, CC	1
Di Serio, C; Pellerito, S; Tarantini, F	1
Cai, L; Hertz, L; Li, B; Nu, W; Peng, L; Zhang, H; Zhang, S	1
Klein, RQ; Lok, W; Saif, MW	1
Chen, B; Chicoine, LG; Cui, H; Nelin, LD; Toby, IT	1
Arlot, Y; Depreux, P; Farce, A; Garofalo, A; Goossens, L; Lemoine, A	1
Mologni, L	1
Chaniyara, R; Chou, TC; Dong, H; Kakadiya, R; Lee, PC; Lee, TC; Marvania, B; Shah, A; Su, TL; Suman, S	1
Abraham, S; Armstrong, RC; Ator, MA; Bhagwat, SS; Campbell, BT; Chao, Q; Cramer, MD; Dorsey, BD; Faraoni, R; Gardner, MF; Gitnick, D; Gunawardane, RN; Holladay, MW; James, J; Lai, AG; Rowbottom, MW; Ruggeri, BR; Setti, E; Sprankle, KG; Tran, L; Williams, M	1
Brdar, I; Deng, X; Faessler, R; Mani, NS; Roessler, A; Sales, ZS; Wu, J	1
Chavatte, P; Depreux, P; Farce, A; Garofalo, A; Goossens, L; Lemoine, A; Ravez, S; Six, P	1
Hirohama, M; Ito, A; Kumar, A; Yoshida, M; Zhang, KY	1
Ding, J; Ji, X; Jiang, H; Li, J; Li, M; Li, Z; Liu, H; Peng, T; Tong, L; Xie, H; Xu, Y; Yang, W; Zhang, X	1
Anderson, C; Bergeron, D; Binch, H; Decker, C; Garcia-Guzman, M; Hadida, S; Joshi, P; Moore, J; terHaar, E; Termin, A; Yoo, S	1
Barczyk, A; Cagnon, A; Depreux, P; Garofalo, A; Goossens, L; Ravez, S; Six, P	1
Elkamhawy, A; Lee, J; Pae, AN; Park, BG; Park, I; Roh, EJ	1
Cai, J; Cao, M; Chen, J; Hong, KH; Ji, M; Li, L; Wang, P; Wu, X; Zong, X	1
Cho, NC; Elkamhawy, A; Pae, AN; Park, JE; Roh, EJ; Sim, T	1
Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H	1
Bastida, CC; Falchook, GS; Kurzrock, R	1
Cao, YX; He, YY; Mao, S; Xiao, X; Xie, XX; Xin, MH; Xuan, W; Zhang, S; Zhang, SQ; Zuo, SJ	1
Crijns, HJ; De Boer, HC; De Jong, AM; Kamphuisen, PW; Kuiper, M; Lau, DH; Linz, D; Lumeij, S; Maass, AH; Rienstra, M; Schotten, U; Spronk, HM; Ten Cate, H; Van Gelder, IC; van Hunnik, A; van Zonneveld, AJ; Verheule, S; Zeemering, S	1
Choi, JH; Kim, JH; Kwak, Y; Lee, SH; Oh, CH; Roh, EJ; Sim, T; Song, C; Yoo, KH	1
Gong, FH; Li, CG; Sun, LP; Xu, YG; Ye, JQ; Yue, XH; Zhang, C; Zhang, HQ	1
Hino, K; Horigome, K; Ikeya, M; Komura, S; Nagata, S; Nishio, M; Ohta, A; Okanishi, Y; Toguchida, J; Yamada, Y; Zhao, C	1
Duan, Y; Fan, H; Hu, L; Qin, X; Wei, D; Xu, Y; Yang, L; Yang, Y; Zheng, K	1
Cao, DY; Gu, JM; Guo, R; Ma, QY; Shi, XW; Wang, L; Wang, YB; Xing, RJ; Xue, N; Yang, Z; Zhang, K	1
Abouzid, KAM; Elrazaz, EZ; Hadi, SRAE; Lasheen, DS; Soliman, DH	1
Chen, CT; Chen, JN; Cheng, L; He, YZ; Li, QY; Li, T; Liu, G; Qin, TS; Sun, YX; Wei, Y; Yao, D; Zhang, GJ	1
Fedorov, AY; Fonareva, IP; Grishin, ID; Ignatov, SK; Konovalova, MV; Kuimov, AN; Maleev, AA; Salnikova, DI; Scherbakov, AM; Shchegravina, ES; Sorokin, DV; Svirshchevskaya, EV; Zapevalova, MV	1

Reviews

4 review(s) available for quinazolines and urea

Article	Year
Small molecular anti-cytokine agents. Medicinal research reviews, 2006, Volume: 26, Issue:1 Topics: ADAM Proteins; ADAM17 Protein; Animals; Caspase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytokines; Humans; Hydroxamic Acids; Imidazoles; Matrix Metalloproteinase Inhibitors; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridazines; Pyridines; Pyrimidines; Quinazolines; Structure-Activity Relationship; Succinates; Thiazoles; Tumor Necrosis Factor-alpha; Urea	2006
Aurora kinase inhibitors as anti-cancer therapy. Anti-cancer drugs, 2010, Volume: 21, Issue:4 Topics: Antineoplastic Agents; Aurora Kinase B; Aurora Kinase C; Aurora Kinases; Benzamides; Benzimidazoles; Cyclohexanecarboxylic Acids; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Neoplasms; Organophosphates; Phenylurea Compounds; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Quinazolines; Thiazoles; Urea	2010
Development of RET kinase inhibitors for targeted cancer therapy. Current medicinal chemistry, 2011, Volume: 18, Issue:2 Topics: Antineoplastic Agents; Humans; Indoles; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Pyrimidines; Quinazolines; Staurosporine; Urea	2011
Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress. Seminars in oncology, 2015, Volume: 42, Issue:6 Topics: Antineoplastic Agents; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Benzamides; Benzazepines; Benzimidazoles; Clinical Trials as Topic; Heterocyclic Compounds, 3-Ring; Humans; Molecular Targeted Therapy; Neoplasms; Norbornanes; Organophosphates; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Quinazolines; Urea	2015

Trials

1 trial(s) available for quinazolines and urea

Article	Year
Prazosin in the therapy of uncontrolled hypertension. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Nov-26, Volume: 52, Issue:23 Topics: Adult; Aged; Clinical Trials as Topic; Creatinine; Female; Humans; Hypertension; Hypotension, Orthostatic; Kidney Failure, Chronic; Male; Middle Aged; Prazosin; Quinazolines; Urea	1977

Other Studies

42 other study(ies) available for quinazolines and urea

Article	Year
[Quinazolinones. 18. Synthesis and H1/H2-antihistaminic action of omega-[2-aryl-2,3-dihydro-4(1H)-quinazolinone-1-yl]alkyl substituted ureas and cyanoguanidines]. Archiv der Pharmazie, 1991, Volume: 324, Issue:5 Topics: Animals; Binding, Competitive; Guanidines; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Myocardium; Quinazolines; Urea	1991
The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice. British journal of cancer, 1991, Volume: 64, Issue:5 Topics: Animals; Carbon Radioisotopes; Cisplatin; Creatinine; Female; Folic Acid; Glomerular Filtration Rate; Inulin; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinazolines; Thiophenes; Thymidylate Synthase; Urea	1991
Synthesis and biological evaluation of some 1-substituted 3-(2-perimidyl)ureas. Archiv der Pharmazie, 1988, Volume: 321, Issue:7 Topics: Anti-Infective Agents; Antineoplastic Agents; Chemical Phenomena; Chemistry; Humans; KB Cells; Quinazolines; Urea	1988
[Sulfur derivatives structurally analogous to benzoylene-urea]. Annales pharmaceutiques francaises, 1974, Volume: 32, Issue:2 Topics: Folic Acid Antagonists; Quinazolines; Thiones; Urea	1974
Experimental studies on the detection of hypnotics using thin layer chromatography. The Kobe journal of medical sciences, 1972, Volume: 18, Issue:1 Topics: Animals; Barbiturates; Carbamates; Chromatography, Thin Layer; Glutethimide; Hypnotics and Sedatives; Phenobarbital; Quinazolines; Rabbits; Stomach; Urea	1972
Use of a new diuretic agent (metolazone) in patients with edema and ascites. Archives of internal medicine, 1973, Volume: 132, Issue:1 Topics: Ascites; Blood Urea Nitrogen; Creatinine; Diuretics; Edema; Furosemide; Humans; Injections, Intravenous; Kidney Diseases; Liver Cirrhosis; Natriuresis; Potassium; Protein Binding; Quinazolines; Sodium; Sulfonamides; Time Factors; Urea	1973
Effect of pertussis toxin on hormonal responsiveness of rat hepatocytes. FEBS letters, 1983, Aug-22, Volume: 160, Issue:1-2 Topics: Adenylate Cyclase Toxin; Animals; Bacterial Toxins; Cyclic AMP; Epinephrine; Female; Glucagon; In Vitro Techniques; Isoproterenol; Kinetics; Liver; Pertussis Toxin; Phosphatidylinositols; Prazosin; Quinazolines; Rats; Rats, Inbred Strains; Urea; Virulence Factors, Bordetella	1983
Effect of prazosin on renal function in chronic congestive cardiac failure. The Medical journal of Australia, 1981, Sep-19, Volume: 2, Issue:6 Topics: Adult; Aged; Body Weight; Creatinine; Gout; Heart Failure; Humans; Kidney; Male; Middle Aged; Prazosin; Quinazolines; Tachycardia; Urea; Vasodilator Agents	1981
Fluorometric determination of cyanate in plasma by conversion to 2,4(1H,3H)-quinazolinedione and separation by high-performance liquid chromatography. Analytical biochemistry, 1993, May-15, Volume: 211, Issue:1 Topics: Adult; Artifacts; Chromatography, High Pressure Liquid; Cyanates; Female; Fluorometry; Humans; Male; Middle Aged; Quinazolines; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Smoking; Urea	1993
PRELIMINARY STUDIES ON THE ACTION OF QUINETHAZONE IN NORMAL SUBJECTS AND IN HYPERTENSIVE PATIENTS. The British journal of clinical practice, 1965, Volume: 19 Topics: Blood; Chlorothiazide; Diuretics; Drug Therapy; Hypertension; Potassium; Quinazolines; Sodium; Sodium, Dietary; Sulfonamides; Toxicology; Urea; Urine	1965
A novel Pd-catalyzed cyclization reaction of ureas for the synthesis of dihydroquinazolinone p38 kinase inhibitors. Bioorganic & medicinal chemistry letters, 2004, Jan-19, Volume: 14, Issue:2 Topics: Animals; Catalysis; Cyclization; Enzyme Inhibitors; Humans; Lead; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Quinazolines; Urea	2004
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties. Journal of medicinal chemistry, 2005, Feb-10, Volume: 48, Issue:3 Topics: Abdominal Pain; Administration, Oral; Analgesics; Animals; Biological Availability; Calcium; Cells, Cultured; Disease Models, Animal; Heterocyclic Compounds, 2-Ring; Humans; Hyperalgesia; Isoquinolines; Models, Molecular; Pain; Quinazolines; Quinolines; Rats; Receptors, Drug; Static Electricity; Structure-Activity Relationship; Urea	2005
Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor. American journal of respiratory cell and molecular biology, 2005, Volume: 33, Issue:4 Topics: Animals; Arginase; Cattle; Cells, Cultured; Cytokines; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; ErbB Receptors; Genistein; Growth Inhibitors; Humans; Isoenzymes; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Pulmonary Artery; Quinazolines; Tumor Necrosis Factor-alpha; Tyrphostins; Urea	2005
Inosine released after hypoxia activates hepatic glucose liberation through A3 adenosine receptors. American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:5 Topics: Adenosine; Adenosine A3 Receptor Antagonists; Animals; Calcium; Cell Hypoxia; Cyclic AMP; Gluconeogenesis; Glucose; Glycogen Phosphorylase; Glycogenolysis; Hepatocytes; Inosine; Liver; Male; Phylogeny; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptor, Adenosine A3; Receptors, G-Protein-Coupled; Receptors, Purinergic; Receptors, Purinergic P1; Triazoles; Urea	2006
From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist. Bioorganic & medicinal chemistry letters, 2006, Oct-01, Volume: 16, Issue:19 Topics: Administration, Oral; Amides; Analgesics, Non-Narcotic; Animals; Biological Availability; Humans; Molecular Conformation; Pain; Quinazolines; Rats; Solubility; Structure-Activity Relationship; TRPV Cation Channels; Urea	2006
Comparison of the effects of PAR1 antagonists, PAR4 antagonists, and their combinations on thrombin-induced human platelet activation. European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3 Topics: Blood Platelets; Crotalid Venoms; Dose-Response Relationship, Drug; Drug Synergism; Humans; In Vitro Techniques; Indazoles; Oligopeptides; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Pyrroles; Quinazolines; Receptor, PAR-1; Receptors, Thrombin; Thrombin; Urea	2006
Comments on "Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis". The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line; Cell Proliferation; Chick Embryo; Endothelial Cells; Humans; Indazoles; Neovascularization, Physiologic; Pyrroles; Quinazolines; Receptor, PAR-1; Urea	2008
Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation. Psychopharmacology, 2008, Volume: 201, Issue:3 Topics: Aminopyridines; Animals; Antidepressive Agents, Second-Generation; Astrocytes; Butadienes; Calcium; Cells, Cultured; Chelating Agents; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fluorobenzenes; Fluoxetine; Gene Expression; Indoles; Maleimides; Mice; Nitriles; Phosphorylation; Piperidines; Protein Kinase C; Proto-Oncogene Proteins c-fos; Quinazolines; Receptor, Serotonin, 5-HT2B; RNA, Messenger; Signal Transduction; Substrate Specificity; Transcriptional Activation; Tyrphostins; Up-Regulation; Urea	2008
Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation. American journal of physiology. Lung cellular and molecular physiology, 2010, Volume: 298, Issue:4 Topics: Arginase; Cell Hypoxia; Cell Proliferation; Endothelial Cells; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Lung; Microvessels; Models, Biological; Quinazolines; RNA, Messenger; RNA, Small Interfering; Time Factors; Tyrphostins; Urea	2010
Quinazoline-urea, new protein kinase inhibitors in treatment of prostate cancer. Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:2 Topics: Amides; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Urea; Vascular Endothelial Growth Factor Receptor-2	2010
Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates. Bioorganic & medicinal chemistry, 2011, Mar-15, Volume: 19, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Humans; Mice; Mice, Nude; Mustard Plant; Neoplasms; Quinazolines; Structure-Activity Relationship; Urea; Xenograft Model Antitumor Assays	2011
4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors. Bioorganic & medicinal chemistry letters, 2011, Sep-15, Volume: 21, Issue:18 Topics: Animals; Dose-Response Relationship, Drug; Mice; Molecular Structure; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Quinazolines; Rats; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution; Urea; Xenograft Model Antitumor Assays	2011
Direct, metal-free amination of heterocyclic amides/ureas with NH-heterocycles and N-substituted anilines in POCl3. The Journal of organic chemistry, 2011, Oct-21, Volume: 76, Issue:20 Topics: Amides; Amination; Aniline Compounds; Anticholesteremic Agents; Azabicyclo Compounds; Benzamides; Catalysis; Chemistry, Pharmaceutical; Erlotinib Hydrochloride; Eszopiclone; Fluorobenzenes; Heterocyclic Compounds; Humans; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Hypoglycemic Agents; Imatinib Mesylate; Molecular Structure; Phosphorus Compounds; Piperazines; Prescription Drugs; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Rosiglitazone; Rosuvastatin Calcium; Sulfonamides; Thiazolidinediones; Urea	2011
Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors. Journal of medicinal chemistry, 2012, Feb-09, Volume: 55, Issue:3 Topics: Antineoplastic Agents; Catalytic Domain; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Quantitative Structure-Activity Relationship; Quinazolines; Urea; Vascular Endothelial Growth Factor Receptor-2	2012
Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors. Bioorganic & medicinal chemistry letters, 2013, Sep-15, Volume: 23, Issue:18 Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Quinazolines; Structure-Activity Relationship; Ubiquitin-Activating Enzymes; Urea	2013
Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor. Bioorganic & medicinal chemistry, 2013, Dec-15, Volume: 21, Issue:24 Topics: Aniline Compounds; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Molecular Structure; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship; Urea	2013
Identification of potent CNS-penetrant thiazolidinones as novel CGRP receptor antagonists. Bioorganic & medicinal chemistry letters, 2014, Feb-01, Volume: 24, Issue:3 Topics: Animals; Azepines; Calcitonin Gene-Related Peptide; Dipeptides; Humans; Imidazoles; Inhibitory Concentration 50; Migraine Disorders; Molecular Structure; Molecular Weight; Piperazines; Protein Binding; Quinazolines; Quinazolinones; Rats; Receptors, Calcitonin Gene-Related Peptide; Thiazolidinediones; Urea	2014
Inhibition of tumor cell growth and angiogenesis by 7-aminoalkoxy-4-aryloxy-quinazoline ureas, a novel series of multi-tyrosine kinase inhibitors. European journal of medicinal chemistry, 2014, May-22, Volume: 79 Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; MCF-7 Cells; Molecular Structure; Neovascularization, Pathologic; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured; Urea; Vascular Endothelial Growth Factor Receptor-2	2014
Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: design, synthesis, and molecular docking study. European journal of medicinal chemistry, 2014, Sep-12, Volume: 84 Topics: Amyloid beta-Peptides; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Humans; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Molecular Docking Simulation; Molecular Structure; Quinazolines; Structure-Activity Relationship; Urea	2014
Discovery of 4-aminoquinazoline--urea derivatives as Aurora kinase inhibitors with antiproliferative activity. Bioorganic & medicinal chemistry, 2014, Nov-01, Volume: 22, Issue:21 Topics: Antineoplastic Agents; Aurora Kinase A; Aurora Kinase B; Benzamides; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Evaluation, Preclinical; Enzyme Activation; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Quinazolines; Structure-Activity Relationship; Urea	2014
Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies. Journal of enzyme inhibition and medicinal chemistry, 2016, Volume: 31, Issue:1 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Discoidin Domain Receptor 1; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Isoenzymes; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Quinazolines; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship; Urea	2016
Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). European journal of medicinal chemistry, 2015, Oct-20, Volume: 103 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Models, Molecular; Molecular Conformation; Quinazolines; Structure-Activity Relationship; Temozolomide; Urea	2015
Combination of 4-anilinoquinazoline, arylurea and tertiary amine moiety to discover novel anticancer agents. Bioorganic & medicinal chemistry, 2016, Jan-15, Volume: 24, Issue:2 Topics: Amines; Aniline Compounds; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship; Urea	2016
Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation. European heart journal, 2017, 01-01, Volume: 38, Issue:1 Topics: Analysis of Variance; Animals; Antithrombins; Atrial Fibrillation; Cell Proliferation; Dabigatran; Female; Fibrinolytic Agents; Fibroblasts; Fibrosis; Goats; Heart Atria; Indazoles; Mice, Transgenic; Nadroparin; Peptide Hydrolases; Pyrroles; Quinazolines; Rats; Receptors, Thrombin; Thrombin; Thrombophilia; Urea	2017
Synthesis of novel arylaminoquinazolinylurea derivatives and their antiproliferative activities against bladder cancer cell line. Bioorganic & medicinal chemistry letters, 2016, 10-15, Volume: 26, Issue:20 Topics: Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Quinazolines; Urea; Urinary Bladder Neoplasms	2016
Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2. European journal of medicinal chemistry, 2017, Jan-05, Volume: 125 Topics: Aniline Compounds; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; ErbB Receptors; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Quinazolines; Urea; Vascular Endothelial Growth Factor Receptor-2	2017
An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva. Stem cell reports, 2018, 11-13, Volume: 11, Issue:5 Topics: Activin Receptors, Type I; Animals; Benzodioxoles; High-Throughput Screening Assays; Humans; Induced Pluripotent Stem Cells; Mice, SCID; Mice, Transgenic; Myositis Ossificans; Ossification, Heterotopic; Oxazoles; Pyrimidines; Quinazolines; Reproducibility of Results; Signal Transduction; TOR Serine-Threonine Kinases; Triazoles; Urea	2018
Discovery of Dioxino[2,3-f]quinazoline derivative VEGFR-2 inhibitors exerting significant antipro-liferative activity in HUVECs and mice. European journal of medicinal chemistry, 2019, Aug-01, Volume: 175 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carbon-13 Magnetic Resonance Spectroscopy; Cell Proliferation; Drug Discovery; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Molecular Docking Simulation; Phenylurea Compounds; Proton Magnetic Resonance Spectroscopy; Quinazolines; Quinolines; Spectrometry, Mass, Electrospray Ionization; Urea; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays	2019
Design, synthesis and antitumor activity of aromatic urea-quinazolines. Future medicinal chemistry, 2019, Volume: 11, Issue:21 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Quinazolines; Urea	2019
Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. Bioorganic chemistry, 2020, Volume: 101 Topics: Cell Line, Tumor; Cell Proliferation; Humans; Quinazolines; Urea; Vascular Endothelial Growth Factor Receptor-2	2020
Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivatives. European journal of medicinal chemistry, 2020, Nov-01, Volume: 205 Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry Techniques, Synthetic; Glutathione Peroxidase; Humans; Intracellular Space; Molecular Docking Simulation; Protein Conformation; Quinazolines; Reactive Oxygen Species; Structure-Activity Relationship; Urea; Urinary Bladder Neoplasms	2020
Synthesis, Molecular Docking, In Vitro and In Vivo Studies of Novel Dimorpholinoquinazoline-Based Potential Inhibitors of PI3K/Akt/mTOR Pathway. International journal of molecular sciences, 2022, Sep-17, Volume: 23, Issue:18 Topics: Cell Line, Tumor; Cell Proliferation; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Reactive Oxygen Species; TOR Serine-Threonine Kinases; Triazines; Urea	2022