Compounds > quinazolines
Page last updated: 2024-08-21

quinazolines and unc 0638

quinazolines has been researched along with unc 0638 in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's20 (83.33)24.3611
2020's4 (16.67)2.80

Authors

AuthorsStudies
Allali-Hassani, A; Arrowsmith, CH; Barsyte-Lovejoy, D; Brown, PJ; Chau, I; Chen, X; Dimaggio, PA; Dong, A; Edwards, A; Ellis, J; Frye, SV; Garcia, BA; Huang, XP; Janzen, WP; Jin, J; Kireev, DB; Labrie, V; Liu, F; Mangano, TJ; Norris, JL; Pattenden, SG; Petronis, A; Rival-Gervier, S; Roth, BL; Siarheyeva, A; Simpson, CD; Tempel, W; Tripathy, A; Vedadi, M; Wang, SC; Wasney, GA; Wigle, TJ1
Hauser, AT; Jung, M1
Chen, X; Choi, E; Davison, J; Georges, G; Loeb, K; Malik, P; Ou, YL; Paddison, PJ; Skutt-Kakaria, K; Torok-Storb, B; Wood, B1
Chen, Y; Fu, S; He, Y; Jiang, H; Li, H; Lin, Q; Shou, J; Sun, S; Wang, Y; Yu, H; Yu, Y1
An, XR; Fu, L; Hou, J; Yan, FX1
Hébert, J; Humphries, RK; Jin, J; Kirschner, J; Krosl, J; Lehnertz, B; Liu, F; Miller, M; Pabst, C; Rossi, FM; Rosten, P; Sauvageau, G; Su, L; Underhill, TM; Yi, L; Yung, E; Zhang, R1
Ea, CK; Lim, YY; Loh, SW; Ng, WL; Yeo, KS1
Chen, X; Gunawardena, HP; Jin, J; Liu, C; Liu, F; Wei, X; Wrobel, JA; Yu, Y; Zhou, L1
Byrnes, C; de Vasconcellos, JF; Dean, A; Kaushal, M; Krivega, I; Lee, YT; Miller, JL1
Fukuda, T; Hayami, R; Kojima, Y; Maeda, I; Miyoshi, Y; Ohta, T; Okada, M; Tsugawa, K; Wu, W1
Bauer, DE; Bernstein, BE; Canver, MC; Dorfman, DM; Ebert, BL; Holson, EB; Krill-Burger, JM; McConkey, M; Orkin, SH; Renneville, A; Van Galen, P1
de Los Santos, T; Golding, MC; Long, CR; Ramĩrez-Carvajal, L; Singh, N1
Dean, A; Krivega, I1
Razali, NB; Sajikumar, S; Sharma, M1
Agarwal, P; Jackson, SP1
Dierkes, T; Sajikumar, S; Sharma, M1
Avivi, S; Canaani, D; Dotan, I; Kanter, I; Kinor, N; Mor, A; Shav-Tal, Y; Tzadok, S1
Hu, JX; Liu, LM; Liu, XR; Wan, HP; Zhang, XQ; Zhou, LH1
Bonner, M; Kim, JY; Liu, Z; Pangeni, R; Raz, DJ; Tong, TR; Wang, J; Wu, J; Yang, L; Yuan, YC; Yuchi, T; Yun, X; Zhang, K1
Arrowsmith, CH; Babault, N; Bacher, J; Barsyte-Lovejoy, D; Brennan, P; Chau, I; Christott, T; Dilworth, D; Fagan, V; Farnie, G; Fedorov, O; Greschik, H; Jin, J; Johansson, C; Jung, M; Li, F; Liu, J; Martini, M; Oppermann, U; Park, KS; Schüle, R; Seifert, L; Vedadi, M; Xiong, Y1
Engel, JD; Fucharoen, S; Hongeng, S; Jearawiriyapaisarn, N; Kaewsakulthong, W; Khamphikham, P; Nualkaew, T; Paiboonsukwong, K; Pongpaksupasin, P; Songdej, D; Sripichai, O1
Heldermon, CD; Kitada, K; Koyama, M; Meacham, AM; Pacak, CA; Santostefano, KE; Tachibana, D; Terada, N; Waldrop, SM; Watanabe, N; Yokoyama, A1
Ambrizi, DR; Bressan, FF; Bridi, A; Chiaratti, MR; da Silveira, JC; de Ávila, ACFCM; De Bem, THC; de Jesus Oliveira, L; Del Collado, M; Macabelli, CH; Meirelles, FV; Perecin, F; Ross, PJ; Sampaio, RV; Sangalli, JR; Smith, LC1
Chen, SY; Chu, PY; Hou, MF; Lin, CS; Lin, HY; Wu, HJ1

Reviews

1 review(s) available for quinazolines and unc 0638

ArticleYear
Chromatin looping as a target for altering erythroid gene expression.
    Annals of the New York Academy of Sciences, 2016, Volume: 1368, Issue:1

    Topics: Animals; beta-Globins; Chromatin; DNA-Binding Proteins; Erythroid Cells; gamma-Globins; Genetic Therapy; Hemoglobinopathies; Histone-Lysine N-Methyltransferase; Humans; LIM Domain Proteins; Quinazolines; Transcription Factors

2016

Other Studies

23 other study(ies) available for quinazolines and unc 0638

ArticleYear
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
    Nature chemical biology, 2011, Jul-10, Volume: 7, Issue:8

    Topics: Animals; Cell Line; Enzyme Inhibitors; Gene Silencing; Histone-Lysine N-Methyltransferase; Humans; Mice; Molecular Structure; Quinazolines

2011
Chemical probes: sharpen your epigenetic tools.
    Nature chemical biology, 2011, Jul-18, Volume: 7, Issue:8

    Topics: Autoantigens; Azepines; Drug Delivery Systems; Enzyme Inhibitors; Epigenesis, Genetic; Golgi Matrix Proteins; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Molecular Structure; Proteins; Quinazolines; Signal Transduction; Structure-Activity Relationship

2011
G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment.
    Genes & development, 2012, Nov-15, Volume: 26, Issue:22

    Topics: Adult; Animals; Cell Differentiation; Cell Lineage; Cells, Cultured; Chromatin; CpG Islands; DNA Methylation; Dogs; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Developmental; Hematopoietic Stem Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Mice; Quinazolines

2012
Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death.
    Cell death & disease, 2013, Feb-21, Volume: 4

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Azepines; Cells, Cultured; Cochlea; Hair Cells, Auditory; Histone-Lysine N-Methyltransferase; Histones; Methylation; Mice; Mice, Inbred C57BL; Models, Animal; Neomycin; Organ of Corti; Quinazolines

2013
Effects of the histone methyltransferase inhibitor UNC0638 on histone H3K9 dimethylation of cultured ovine somatic cells and development of resulting early cloned embryos.
    Reproduction in domestic animals = Zuchthygiene, 2014, Volume: 49, Issue:2

    Topics: Animals; Cloning, Organism; Embryo, Mammalian; Embryonic Development; Fibroblasts; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Methylation; Quinazolines; Sheep

2014
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
    Genes & development, 2014, Feb-15, Volume: 28, Issue:4

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hematopoietic Stem Cells; Histone-Lysine N-Methyltransferase; Homeodomain Proteins; Humans; Leukemia, Myeloid, Acute; Mice, Inbred C57BL; Quinazolines

2014
Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Azepines; Benzamides; Cell Proliferation; Drug Synergism; Gene Expression; HeLa Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Imatinib Mesylate; Interferon Type I; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Pyrimidines; Quinazolines

2014
A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing.
    Nature communications, 2014, Dec-15, Volume: 5

    Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Line; Chromatin; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Female; Histone-Lysine N-Methyltransferase; Histones; Immune Tolerance; Inflammation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Primary Cell Culture; Proteomics; Proto-Oncogene Proteins c-myc; Quinazolines; RNA, Small Interfering; Signal Transduction; Transcription, Genetic

2014
Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping.
    Blood, 2015, Jul-30, Volume: 126, Issue:5

    Topics: Adult; Anemia, Sickle Cell; beta-Thalassemia; Cell Differentiation; DNA-Binding Proteins; Enzyme Inhibitors; Epigenesis, Genetic; Erythroid Precursor Cells; Erythropoiesis; Fetal Hemoglobin; gamma-Globins; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; In Vitro Techniques; LIM Domain Proteins; Locus Control Region; Models, Biological; Promoter Regions, Genetic; Quinazolines; Transcription Factors

2015
Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage.
    Cancer science, 2015, Volume: 106, Issue:8

    Topics: Blotting, Western; BRCA1 Protein; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Repair; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Microscopy, Fluorescence; Neoplasms; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor p53-Binding Protein 1

2015
EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.
    Blood, 2015, Oct-15, Volume: 126, Issue:16

    Topics: Anemia, Sickle Cell; Animals; Cell Line, Tumor; Epigenesis, Genetic; Erythroblasts; Erythroid Cells; Female; Fetal Hemoglobin; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Male; Mice; Quinazolines

2015
Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2016, Volume: 36, Issue:1

    Topics: 2',5'-Oligoadenylate Synthetase; Animals; Cattle; Cell Line; DEAD-box RNA Helicases; eIF-2 Kinase; Epigenesis, Genetic; Epithelial Cells; Euchromatin; Fetus; Fibroblasts; Foot-and-Mouth Disease Virus; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Immunity, Innate; Interferon-beta; Myxovirus Resistance Proteins; Poly I-C; Primary Cell Culture; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transcription, Genetic; Ubiquitins; Vesicular stomatitis Indiana virus

2016
Inhibition of G9a/GLP Complex Promotes Long-Term Potentiation and Synaptic Tagging/Capture in Hippocampal CA1 Pyramidal Neurons.
    Cerebral cortex (New York, N.Y. : 1991), 2017, 06-01, Volume: 27, Issue:6

    Topics: Animals; Azepines; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Chromatin Immunoprecipitation; Electric Stimulation; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; In Vitro Techniques; Long-Term Potentiation; Male; Models, Biological; Pyramidal Cells; Quinazolines; Rats; Rats, Wistar; Synapses

2017
G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status.
    Cancer letters, 2016, 10-01, Volume: 380, Issue:2

    Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; DNA Breaks, Double-Stranded; DNA End-Joining Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; HCT116 Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Neoplasms; Phleomycins; Quinazolines; RNA Interference; Signal Transduction; Time Factors; Topoisomerase II Inhibitors; Transfection; Tumor Suppressor Protein p53

2016
Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons.
    Aging cell, 2017, Volume: 16, Issue:5

    Topics: Amyloid beta-Peptides; Animals; Azepines; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Cognitive Dysfunction; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Long-Term Potentiation; Male; Microtomy; Peptide Fragments; Pyramidal Cells; Quinazolines; Rats; Rats, Wistar; Receptor, trkB; Synapses; Tissue Culture Techniques

2017
Visualizing nuclear RNAi activity in single living human cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 10-17, Volume: 114, Issue:42

    Topics: Cell Nucleus; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; In Situ Hybridization, Fluorescence; Microscopy, Fluorescence; Molecular Imaging; Piperazines; Promoter Regions, Genetic; Quinazolines; RNA Interference; RNA Precursors; RNA, Small Interfering; Transcription Initiation Site

2017
UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer.
    Molecular medicine reports, 2018, Volume: 17, Issue:2

    Topics: Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Female; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Neoplastic Stem Cells; Quinazolines; Triple Negative Breast Neoplasms

2018
Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1α and APC2 gene expression in non-small cell lung cancer.
    Molecular cancer, 2018, 10-22, Volume: 17, Issue:1

    Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Cytoskeletal Proteins; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Mice; Quinazolines; Wnt Signaling Pathway; Xenograft Model Antitumor Assays

2018
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
    Journal of medicinal chemistry, 2019, 10-24, Volume: 62, Issue:20

    Topics: Cell Cycle Proteins; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Drug Discovery; HEK293 Cells; Humans; Microtubule-Associated Proteins; Molecular Structure; Phosphoproteins; Proton Magnetic Resonance Spectroscopy; Quinazolines

2019
UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells.
    Annals of hematology, 2020, Volume: 99, Issue:9

    Topics: beta-Thalassemia; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Erythroid Precursor Cells; Fetal Hemoglobin; Gene Expression; Hemoglobin E; Humans; Quinazolines

2020
Generation of Induced Pluripotent Stem Cells from a Female Patient with a Xq27.3-q28 Deletion to Establish Disease Models and Identify Therapies.
    Cellular reprogramming, 2020, Volume: 22, Issue:4

    Topics: Cell Differentiation; Cells, Cultured; Child, Preschool; Chromosome Deletion; Chromosomes, Human, X; Decitabine; Developmental Disabilities; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Induced Pluripotent Stem Cells; Intellectual Disability; Quinazolines

2020
Catalytic inhibition of H3K9me2 writers disturbs epigenetic marks during bovine nuclear reprogramming.
    Scientific reports, 2020, 07-13, Volume: 10, Issue:1

    Topics: Animals; Blastocyst; Cattle; Cell Differentiation; Cellular Reprogramming; Cloning, Organism; DNA Methylation; Embryo Transfer; Embryonic Development; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histocompatibility Antigens; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Nuclear Transfer Techniques; Oocytes; Protein Processing, Post-Translational; Quinazolines

2020
Epigenetic therapy combination of UNC0638 and CI-994 suppresses breast cancer via epigenetic remodeling of BIRC5 and GADD45A.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 145

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Disease Progression; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice, Inbred NOD; Mice, SCID; Phenylenediamines; Quinazolines; Survivin; Xenograft Model Antitumor Assays

2022