quinazolines has been researched along with tryptanthrine in 100 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.00) | 18.7374 |
| 1990's | 1 (1.00) | 18.2507 |
| 2000's | 32 (32.00) | 29.6817 |
| 2010's | 54 (54.00) | 24.3611 |
| 2020's | 12 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, L; Zou, JC | 1 |
| Fiedler, HP; Riebniger, D; Schrenk, D; Till, M; Vetter, S | 1 |
| Ikeda, M; Ishihara, T; Iwaki, K; Kohno, K; Kurimoto, M; Ushio, S | 1 |
| Hirata, K; Ikeda, M; Iwaki, K; Kataoka, M; Kunikata, T; Kurimoto, M; Ohashi, K; Ushio, S | 1 |
| Hino, K; Ikeda, M; Iwaki, K; Kimoto, T; Koya-Miyata, S; Kurimoto, M; Micallef, MJ; Nishizaki, Y; Takeuchi, M; Ushio, S; Yamamoto, Y | 1 |
| Brattström, A; Danz, H; Hamburger, M; Stoyanova, S; Wippich, P | 1 |
| Blank, E; Konnick, M; Nenortas, E; Scovill, J; Shapiro, T | 1 |
| Baumann, D; Danz, H; Hamburger, M | 1 |
| Aga, M; Ikeda, M; Ishihara, T; Iwaki, K; Kimoto, T; Koya-Miyata, S; Kunikata, T; Kurimoto, M; Micallef, MJ; Ushio, S | 1 |
| Ajaykumar, R; Babu, PA; Deevi, DS; Kumar, GS; Kumar, KB; Mamidi, NV; Narasimhulu, CP; Prasanna, P; Puranik, RC; Rajagopal, S; Rajagopalan, R; Rao, CS; Rao, CV; Renuka, B; Seshu, KV; Sharma, VM; Subramanyam, D; Venkateswarlu, A | 1 |
| Hamburger, M; Hoffmann, B; Oberthür, C | 1 |
| Dannhardt, G; Danz, H; Hamburger, M; Simon, HU; Stoyanova, S; Thomet, OA; Ulbrich, H | 1 |
| Aga, M; Ikeda, M; Inoue, S; Iwaki, K; Kunikata, T; Kurimoto, M; Takei, Y; Ushio, S | 1 |
| Benfeldt, E; Elsner, P; Hamburger, M; Heinemann, C; Oberthür, C | 1 |
| Bhattacharjee, AK; Hartell, MG; Hicks, RP; Milhous, WK; Nichols, DA; Stanton, B; van Hamont, JE | 1 |
| Elsner, P; Hamburger, M; Heinemann, C; Oberthür, C; Schliemann-Willers, S | 1 |
| Hamburger, M; Oberthür, C | 1 |
| Gohda, E; Motoki, T; Tai, A; Takami, Y; Yagi, Y; Yamamoto, I | 1 |
| Hamburger, M; Jäggi, R; Oberthür, C | 1 |
| Cai, YL; Ruan, JL; Zou, JH | 1 |
| Cerdá-Nicolás, M; Hamburger, M; Potterat, O; Recio, MC; Ríos, JL | 1 |
| Chen, SS; Jong, TT; Lee, MR; Liau, BC | 1 |
| Bowman, WR; Elsegood, MR; Stein, T; Weaver, GW | 1 |
| Hamburger, M; Mohn, T; Potterat, O | 1 |
| Bhagwat, BV; Chen, GS; Chen, HT; Chern, JW; Liao, PY; Lin, SB | 1 |
| Chen, TM; Chen, YH; Tseng, SY; Yu, ST | 1 |
| Jahng, Y; Jeong, TC; Kim, DH; Kim, GH; Lee, SK | 1 |
| Elsohly, MA; Gul, W | 1 |
| Jahng, KC; Jahng, Y; Kim, DH; Kim, SI; Lee, ES; Lee, SH; Seo, CS; Son, JK | 1 |
| Jao, CW; Lin, WC; Wu, PL; Wu, YT | 1 |
| Grundt, P; Jones-Brando, L; Krivogorsky, B; Yolken, R | 1 |
| Chen, TM; Chen, YH; Chern, JW; Tseng, SY; Yu, ST | 1 |
| Chan, HL; Leung, KN; Mak, NK; Yip, HY | 1 |
| Chiba, K; Ito, S; Kawakami, J; Kikuchi, K; Kitahara, H; Matsushima, N; Nagaki, M; Yamaya, A | 1 |
| Chen, HT; Chen, TM; Chen, YH; Chern, JW; Chiu, YF; Yu, ST | 1 |
| Bandekar, PP; Mitchell, TR; Novak, MJ; Parekh, VJ; Roopnarine, KA; Sinden, RR | 1 |
| Arai, N; Fukuda, S; Iwaki, K; Kohno, K; Ohashi, E; Taniguchi, M; Ushio, S | 1 |
| Fang, JY; Fang, YP; Lin, YK; Su, YH | 1 |
| Hua, W; Miao, Q; Miao, S; Shi, X; Sun, J; Wang, S; Zhang, C; Zhang, H; Zhao, Y | 1 |
| Hamburger, M; Jazzar, B; Northoff, H; Pergola, C; Rossi, A; Sautebin, L; Werz, O | 1 |
| Ma, G; Wang, H; Yan, J; Yang, Q; Zhang, X; Zhu, X | 1 |
| Adema, GJ; Gaitanis, G; Magiatis, P; Schulte, BM; Vlachos, C | 1 |
| Jahng, Y; Kwon, Y; Liang, JL; Park, SE | 1 |
| Douglas, KA; Grundt, P; Krivogorsky, B; Nelson, AC | 1 |
| Bindal, D; Jana, T; Tripathi, A; Wadia, N | 1 |
| Cho, SN; Franzblau, SG; Hwang, JM; Kaneko, T; Kim, P; Ma, Z; Oh, T; Upton, AM | 1 |
| Leung, KN; Liao, X | 1 |
| Jahng, Y | 1 |
| Lu, P; Ren, A; Wang, C; Wang, Y; Zhang, L | 1 |
| Argade, NP; Vaidya, SD | 1 |
| Gao, H; Jiang, J; Kang, G; Liu, C; Luo, Z; Wu, H; Wu, Q | 1 |
| Hu, F; Kuang, C; Li, X; Li, Y; Yan, J; Yang, Q; Yang, S; Yang, Y | 1 |
| Baum, JC; German, HW; Kummerer, TM; Novak, MJ; Sinden, RR; Terryn, RJ | 1 |
| Han, NR; Jeong, HJ; Kim, HM; Moon, PD | 1 |
| Leung, KN; Liao, X; Mak, NK; Zhou, X | 1 |
| Exner, M; Gmeiner, BM; Hermann, M; Jirovetz, L; Kapiotis, S; Laggner, H; Praschberger, M; Wanner, J | 1 |
| Hua, Y; Liu, J; Liu, Z; Sun, Y; Wang, C; Wang, Z; Zhang, N | 1 |
| Cho, IJ; Choi, HY; Kim, SC; Kim, YW; Lee, JH; Moon, SY | 1 |
| Aithagani, SK; Bhushan, S; Guru, SK; Kumar, A; Kumar, S; Malik, F; Pathania, AS; Sharma, PR; Singh, PP; Vishwakarma, RA | 1 |
| Anto, RJ; Antony, J; Chandran, H; Joseph, SM; Katiki, MR; Murty, MS; Nath, LR; Nishanth, KS; Panakkal, EJ; Paul, A; Rajan, E; Ran, S; Saikia, M; Sankar, S; Shabna, A; Sridivya, I; Sriramya, I; Vinod, V | 1 |
| Liao, FM; Liu, YL; Yu, JS; Zhou, F; Zhou, J | 1 |
| Chang, HN; Huang, ST; Pang, JH; Wang, HS; Wang, TH; Wu, YH; Yeh, YC | 1 |
| Czyz, M; Gajos-Michniewicz, A | 1 |
| Ito, S; Kawakami, J; Kitahara, H; Takahashi, M | 1 |
| Han, NR; Jeong, HJ; Kim, HM | 1 |
| Butterweck, V; Cecchelli, R; Culot, M; Deli, MA; Eigenmann, DE; Gosselet, F; Hamburger, M; Jähne, EA; Oufir, M; Sampath, C; Smieško, M; Walter, FR | 1 |
| Butterweck, V; Eigenmann, DE; Hamburger, M; Hebeisen, S; Hettich, T; Jähne, EA; Moradi-Afrapoli, F; Oufir, M; Schlotterbeck, G; Smieško, M; Verjee, S | 1 |
| Guo, Z; Hu, N; Kuang, C; Li, J; Li, Y; Yang, D; Yang, Q | 1 |
| Chen, CY; Cheng, HT; Chu, YH; Li, HY | 1 |
| Babu, R; Guda, R; Kasula, M; Kumar, G; Lingabathula, H; Muthadi, S; Narsimha, S; Palabindela, R; Yellu, NR | 1 |
| Alviano, CS; Alviano, DS; Azevedo, MMB; Costa, DCM; Romanos, MTV; Silva, DOE; Souto-Padrón, TCBS | 1 |
| Fan, X; Guo, S; Zhai, J | 1 |
| Kaur, R; Kumar, K; Manjal, SK; Rawal, RK | 1 |
| Cho, IJ; Jung, DH; Jung, EH; Jung, JY; Kim, JK; Kim, SC; Kim, YW; Ko, HL; Ku, SK; Park, CA; Park, SM | 1 |
| Fan, F; He, L; Hou, X; Sun, Y; Wang, J; Wu, H; Xu, H | 1 |
| Baum, JC; Novak, MJ; Olson, JA; Stewart, EL; Terryn, RJ | 1 |
| Baek, HY; Kim, DC; Kim, YC; Lee, KD; Lee, S; Oh, H | 1 |
| Liang, YN; Liu, JL; Sun, C; Tang, DX; Tang, ZS; Wang, CL; Wang, L; Wang, Z; Wu, X; Zhang, DB | 1 |
| Agafonova, IG; Moskovkina, TV | 1 |
| Aguinaldo, AM; Attah, IK; Bowden, ME; Chouinard, CD; Colby, SM; Cort, JR; Franzblau, SG; Garcellano, RC; Ibrahim, YM; Lewis, NG; Ma, R; Moinuddin, SGA; Nagy, G; Renslow, RS; Thomas, DG; Yesiltepe, Y; Young, RP; Zhou, M | 1 |
| Fang, H; Han, N; Liang, Y; Liu, J; Wang, C; Wang, X; Xiao, Z; Zhu, A | 1 |
| Fang, X; Hu, H; Huang, Q; Kuang, C; Qi, F; Yang, D; Yang, Q; Zhang, S | 1 |
| Abdoli, A; Pedras, MSC; Thapa, C; To, QH | 1 |
| Aksakal, F; Boldescu, V; Duca, G; Macaev, F; Negres, S; Nicolescu, F; Pogrebnoi, S; Uncu, A; Uncu, L; Valica, V | 1 |
| Chang, HN; Chueh, HY; Pang, JS; Yeh, YC | 1 |
| Dai, W; He, B; Meng, X; Qin, M; Wang, D; Wang, X; Yang, C; Zhang, H; Zhang, Q; Zheng, Q | 1 |
| Denison, MS; He, G; Koutrakis, S; Magiatis, P; Mexia, N; Skaltsounis, AL | 1 |
| Alex, VV; Anto, RJ; Bava, SV; Chittalakkottu, S; Nisthul A, A; Retnakumari, AP; Shankar G, M; Sundaram, S | 1 |
| Krishnankutty Chandrika, S; Narendrakumar, L; Theresa, M; Thomas, S | 1 |
| Elsner, P; Hesse-Macabata, J; Hipler, UC; Morgner, B; Wiegand, C | 1 |
| Chang, CH; Chang, CN; Chang, CY; Cheng, HM; Fang, WY; Kuo, YZ; Lin, JY; Pan, SC; Wu, LW | 1 |
| Cui, M; Kuang, C; Li, Y; Liu, W; Wang, R; Yang, Q; Zhang, S | 1 |
| Jayaraman, J; Maxwell, A; Ramkissoon, A; Ramsubhag, A; Seepersaud, M | 1 |
| Deriabin, P; Dezhenkova, L; Gerasimenko, A; Grammatikova, N; Kaluzhny, D; Klimovich, A; Moskovkina, T; Popov, A; Shchekotikhin, A; Stonik, V; Styshova, O; Udovenko, A | 1 |
| Cho, J; Lai, D; Luo, C; Shen, X; Zeng, Q; Zhang, X; Zhou, W | 1 |
| Asari, T; Ding, J; Fukuda, S; Hiraga, H; Imaizumi, T; Kawaguchi, S; Kikuchi, H; Matsumiya, T; Numao, N; Sakuraba, H; Seya, K | 1 |
| Fang, Z; Han, J; Lin, J; Lin, Y; Peng, W; Qin, Y; Shi, X; Xiao, F; Xu, X; Zhang, Y; Zhao, L | 1 |
| Pineiro, M; Pinheiro, D; Seixas de Melo, JS | 1 |
| Ding, J; Fukuda, S; Imaizumi, T; Karasawa, T; Kawaguchi, S; Kikuchi, H; Matsumiya, T; Numao, N; Sakuraba, H; Seya, K | 1 |
| Akhir, A; Chopra, S; Deepthi, A; Kaul, G; Saxena, D; Sudheendran Leena, S | 1 |
4 review(s) available for quinazolines and tryptanthrine
| Article | Year |
|---|---|
Recent patent reviews on small molecule-based antimalarial drugs.
Topics: Aminoquinolines; Animals; Antigens, Protozoan; Antimalarials; Artemisinins; Biological Assay; Flavonoids; Hepatocyte Growth Factor; Humans; Malaria; Malaria Vaccines; Patents as Topic; Plant Extracts; Primaquine; Protease Inhibitors; Quinazolines; Triazines | 2007 |
Progress in the studies on tryptanthrin, an alkaloid of history.
Topics: Animals; Crystallography, X-Ray; Drug Discovery; Humans; Molecular Structure; Quinazolines; Structure-Activity Relationship | 2013 |
Modulation of WNT/β-catenin pathway in melanoma by biologically active components derived from plants.
Topics: Animals; Clinical Trials as Topic; Flavonoids; Flavonols; Humans; Melanoma; Pentacyclic Triterpenes; Phytochemicals; Quinazolines; Silymarin; Wnt Signaling Pathway | 2016 |
Recent synthetic and medicinal perspectives of tryptanthrin.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Bacteria; Drug Resistance, Neoplasm; Humans; Quinazolines; Toxoplasma | 2017 |
1 trial(s) available for quinazolines and tryptanthrine
| Article | Year |
|---|---|
Prevention of experimentally induced irritant contact dermatitis by extracts of Isatis tinctoria compared to pure tryptanthrin and its impact on UVB-induced erythema.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Dermatitis, Allergic Contact; Drugs, Chinese Herbal; Erythema; Female; Humans; Isatis; Male; Phytotherapy; Plant Extracts; Plant Leaves; Quinazolines; Single-Blind Method; Sodium Dodecyl Sulfate; Treatment Outcome; Ultraviolet Rays | 2004 |
95 other study(ies) available for quinazolines and tryptanthrine
| Article | Year |
|---|---|
[Minor constituents of qing dai, a traditional Chinese medicine. I. Isolation, structural determination and synthesis of tryptanthrin and qingdainone].
Topics: Antineoplastic Agents, Phytogenic; Chemical Phenomena; Chemistry; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Plants, Medicinal; Quinazolines | 1985 |
Tryptanthrins: a novel class of agonists of the aryl hydrocarbon receptor.
Topics: Animals; Candida; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Enzyme Induction; L-Lactate Dehydrogenase; Liver; Male; Mice; Polychlorinated Dibenzodioxins; Quinazolines; Rats; Rats, Wistar; Receptors, Aryl Hydrocarbon; RNA; Tumor Cells, Cultured | 1997 |
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cyclooxygenase 2; Dinoprostone; Isoenzymes; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Quinazolines | 2000 |
Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils.
Topics: Animals; Drugs, Chinese Herbal; Flavonoids; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Kaempferols; Male; Polygonaceae; Quercetin; Quinazolines | 2001 |
Cell differentiation and apoptosis of monocytic and promyelocytic leukemia cells (U-937 and HL-60) by tryptanthrin, an active ingredient of Polygonum tinctorium Lour.
Topics: Antigens, CD; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspases; Cell Differentiation; Cell Division; Cell Nucleus; DNA, Neoplasm; Dose-Response Relationship, Drug; Esterases; fas Receptor; HL-60 Cells; Humans; Membrane Potentials; Mitochondria; Nitroblue Tetrazolium; Phagocytosis; Quinazolines; U937 Cells | 2001 |
Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Brassicaceae; Cells; Coloring Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Enzyme Inhibitors; Isoenzymes; Molecular Structure; Plant Extracts; Plant Leaves; Plant Roots; Prostaglandin-Endoperoxide Synthases; Quinazolines | 2001 |
Antitrypanosomal activities of tryptanthrins.
Topics: Animals; Cells, Cultured; Humans; Quinazolines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2002 |
Quantitative determination of the dual COX-2/5-LOX inhibitor tryptanthrin in Isatis tinctoria by ESI-LC-MS.
Topics: Arachidonate 5-Lipoxygenase; Brassicaceae; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Drugs, Chinese Herbal; Isoenzymes; Lipoxygenase Inhibitors; Molecular Structure; Plant Extracts; Plant Leaves; Prostaglandin-Endoperoxide Synthases; Quinazolines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Spectrum Analysis | 2002 |
The natural plant product tryptanthrin ameliorates dextran sodium sulfate-induced colitis in mice.
Topics: Animals; Biological Factors; Colitis; Colon; Cytokines; Dextran Sulfate; Dinoprostone; Drugs, Chinese Herbal; Female; Gene Expression; Mice; Mice, Inbred C57BL; Mitogens; Nitric Oxide; Phytotherapy; Polygonum; Quinazolines; Spleen; Time Factors | 2002 |
Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure-activity relationship.
Topics: Animals; Antineoplastic Agents; Biological Availability; Cell Division; Drug Screening Assays, Antitumor; Humans; Indoles; Male; Mice; Neoplasms, Experimental; Quinazolines; Structure-Activity Relationship; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Synthesis of d-tryptanthrin.
Topics: Brassicaceae; Chromatography, High Pressure Liquid; Indicators and Reagents; Magnetic Resonance Spectroscopy; Plants, Medicinal; Quinazolines; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 2002 |
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis.
Topics: Animals; Brassicaceae; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Isoenzymes; Leukotriene B4; Membrane Proteins; Neutrophils; Phytotherapy; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Quinazolines; Sheep | 2002 |
Tryptanthrin inhibits interferon-gamma production by Peyer's patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Enterotoxins; Female; In Vitro Techniques; Interferon-gamma; Interleukin-2; Lymphocytes; Mice; Mice, Inbred BALB C; Peyer's Patches; Quinazolines; Time Factors | 2003 |
A comparative study on the skin penetration of pure tryptanthrin and tryptanthrin in Isatis tinctoria extract by dermal microdialysis coupled with isotope dilution ESI-LC-MS.
Topics: Animals; Chromatography, Liquid; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Isatis; Microdialysis; Phytotherapy; Plant Extracts; Plant Leaves; Quinazolines; Skin; Skin Absorption; Swine | 2003 |
Structure-activity relationship study of antimalarial indolo [2,1-b]quinazoline-6,12-diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates.
Topics: Animals; Antimalarials; Drug Resistance, Multiple; Hydrogen Bonding; Imaging, Three-Dimensional; Models, Molecular; Molecular Conformation; Parasitic Sensitivity Tests; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Quinazolines | 2004 |
Tryptanthrin content in Isatis tinctoria leaves--a comparative study of selected strains and post-harvest treatments.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brassicaceae; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Humans; Phytotherapy; Plant Leaves; Quinazolines; Spectrometry, Mass, Electrospray Ionization | 2004 |
Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by tryptanthrin.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Hepatocyte Growth Factor; Humans; Infant, Newborn; Quinazolines; Skin | 2005 |
HPLC based activity profiling for 5-lipoxygenase inhibitory activity in Isatis tinctoria leaf extracts.
Topics: alpha-Linolenic Acid; Chromatography, High Pressure Liquid; HL-60 Cells; Humans; Isatis; Lipoxygenase Inhibitors; Molecular Structure; Plant Extracts; Plant Leaves; Quinazolines | 2005 |
[Studies on chemical constituents in leaf of Isatis indigotica].
Topics: Drugs, Chinese Herbal; Indoles; Isatis; Plant Leaves; Plants, Medicinal; Pyrrolidonecarboxylic Acid; Quinazolines | 2005 |
Anti-inflammatory and antiallergic activity in vivo of lipophilic Isatis tinctoria extracts and tryptanthrin.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Carrageenan; Drugs, Chinese Herbal; Edema; Female; Hypersensitivity; Isatis; Mice; Phytotherapy; Plant Extracts; Plant Leaves; Quinazolines; Tetradecanoylphorbol Acetate | 2006 |
LC-APCI-MS method for detection and analysis of tryptanthrin, indigo, and indirubin in daqingye and banlangen.
Topics: Calibration; Chromatography, High Pressure Liquid; Coloring Agents; Drugs, Chinese Herbal; Indicators and Reagents; Indigo Carmine; Indoles; Isatis; Mass Spectrometry; Plant Leaves; Plant Roots; Quinazolines; Reference Standards; Reproducibility of Results | 2007 |
Radical reactions with 3H-quinazolin-4-ones: synthesis of deoxyvasicinone, mackinazolinone, luotonin A, rutaecarpine and tryptanthrin.
Topics: Alkaloids; Cyclization; Free Radicals; Indole Alkaloids; Molecular Structure; Pyrroles; Quinazolines; Quinazolinones; Quinones | 2007 |
Quantification of active principles and pigments in leaf extracts of Isatis tinctoria by HPLC/UV/MS.
Topics: alpha-Linolenic Acid; Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Indigo Carmine; Indoles; Isatis; Mass Spectrometry; Models, Animal; Plant Extracts; Plant Leaves; Quinazolines; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2007 |
Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives.
Topics: Chemical Phenomena; Chemistry, Physical; Circular Dichroism; DNA; Indoles; Ligands; Nucleic Acid Conformation; Quinazolines; Spectrophotometry, Ultraviolet | 2007 |
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Mutation; Promoter Regions, Genetic; Quinazolines; Tumor Suppressor Protein p53 | 2007 |
Identification of a tryptanthrin metabolite in rat liver microsomes by liquid chromatography/electrospray ionization-tandem mass spectrometry.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; In Vitro Techniques; Isatis; Male; Microsomes, Liver; Proadifen; Quinazolines; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry | 2007 |
One-pot synthesis of simple alkaloids: 2,3-polymethylene-4(3H)-quinazolinones, luotonin A, tryptanthrin, and rutaecarpine.
Topics: Chemical Phenomena; Chemistry, Physical; Indicators and Reagents; Indole Alkaloids; Lactams; Magnetic Resonance Spectroscopy; ortho-Aminobenzoates; Pyrroles; Quinazolines; Quinazolinones; Quinones; Spectrophotometry, Infrared | 2008 |
Isolation, structure elucidation, and synthesis of cytotoxic tryptanthrin analogues from Phaius mishmensis.
Topics: Antineoplastic Agents, Phytogenic; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Molecular Structure; Orchidaceae; Plants, Medicinal; Quinazolines; Taiwan | 2008 |
Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.
Topics: Animals; Antiprotozoal Agents; Drugs, Chinese Herbal; Indoles; Isatis; Parasitic Sensitivity Tests; Quinazolines; Toxoplasma | 2008 |
Downregulation of GSTpi expression by tryptanthrin contributing to sensitization of doxorubicin-resistant MCF-7 cells through c-jun NH2-terminal kinase-mediated apoptosis.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Enzyme Induction; Female; Glutathione S-Transferase pi; Humans; JNK Mitogen-Activated Protein Kinases; Neoplasm Proteins; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Quinazolines | 2009 |
Modulatory effects and action mechanisms of tryptanthrin on murine myeloid leukemia cells.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D2; Cyclin D3; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Dose-Response Relationship, Drug; Down-Regulation; Drugs, Chinese Herbal; Gene Expression Regulation, Leukemic; Leukemia, Myeloid; Macrophages, Peritoneal; Mice; Myelopoiesis; Quinazolines; Time Factors | 2009 |
2-Aminotryptanthrin derivative with pyrene as a FRET-based fluorescent chemosensor for Al3+.
Topics: Aluminum; Chemistry Techniques, Analytical; Fluorescence Resonance Energy Transfer; Polyethylene Glycols; Pyrenes; Quinazolines | 2009 |
Cytotoxicity and reversal of multidrug resistance by tryptanthrin-derived indoloquinazolines.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Indolequinones; Quinazolines | 2010 |
Antimicrobial activity of tryptanthrins in Escherichia coli.
Topics: Anti-Bacterial Agents; Escherichia coli; Intercalating Agents; Mutagenesis; Quinazolines; Structure-Activity Relationship | 2010 |
Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells.
Topics: Animals; Anti-Allergic Agents; Antigens, Plant; Basophils; Cell Degranulation; Cell Differentiation; Cell Line, Tumor; Down-Regulation; Female; Hypersensitivity; Immunoglobulin E; Interleukin-4; Leukemia, Basophilic, Acute; Mast Cells; Mice; Mice, Inbred BALB C; Phosphorylation; Phytotherapy; Plant Extracts; Polygonum; Proto-Oncogene Proteins c-maf; Quinazolines; Rats; RNA, Messenger; Signal Transduction; Th2 Cells | 2011 |
Tryptanthrin-loaded nanoparticles for delivery into cultured human breast cancer cells, MCF7: the effects of solid lipid/liquid lipid ratios in the inner core.
Topics: Breast Neoplasms; Drug Delivery Systems; Female; Humans; Lipids; Nanoparticles; Quinazolines; Solubility; Tumor Cells, Cultured | 2011 |
Proliferation-attenuating and apoptosis-inducing effects of tryptanthrin on human chronic myeloid leukemia K562 cell line in vitro.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Cytochromes c; DNA Fragmentation; Enzyme Activation; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Quinazolines | 2011 |
On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo.
Topics: Adult; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Calcium; Carrageenan; Cells, Cultured; Drugs, Chinese Herbal; Humans; Leukotriene Antagonists; Leukotrienes; Male; Mitogen-Activated Protein Kinases; Neutrophils; Pleurisy; Quinazolines; Rats; Rats, Wistar; Reactive Oxygen Species | 2012 |
Transport characteristics of tryptanthrin and its inhibitory effect on P-gp and MRP2 in Caco-2 cells.
Topics: Antitubercular Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Diffusion; Digoxin; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Enzyme Inhibitors; Glyburide; Humans; Hypoglycemic Agents; Intestinal Mucosa; Intestines; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Permeability; Quinazolines | 2011 |
Malassezia-derived indoles activate the aryl hydrocarbon receptor and inhibit Toll-like receptor-induced maturation in monocyte-derived dendritic cells.
Topics: Aryl Hydrocarbon Hydroxylases; Carbazoles; Cells, Cultured; Cellular Senescence; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Dendritic Cells; Humans; Indoles; Interleukin-12; Interleukin-6; Malassezia; Monocytes; Quinazolines; Receptors, Aryl Hydrocarbon; Toll-Like Receptors | 2012 |
Synthesis of benzo-annulated tryptanthrins and their biological properties.
Topics: Animals; Cattle; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Molecular Structure; Quinazolines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2012 |
Tryptanthrin derivatives as Toxoplasma gondii inhibitors--structure-activity-relationship of the 6-position.
Topics: Alcohols; Humans; Hydrazones; Oximes; Quinazolines; Structure-Activity Relationship; Toxoplasma | 2013 |
Docking studies on novel alkaloid tryptanthrin and its analogues against enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis.
Topics: Amino Acid Sequence; Antitubercular Agents; Bacterial Proteins; Binding Sites; Drug Design; Kinetics; Molecular Sequence Data; Mycobacterium tuberculosis; Oxidoreductases; Protein Conformation; Quinazolines | 2012 |
Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents.
Topics: Animals; Antitubercular Agents; Cytochrome P-450 Enzyme System; Drug Design; Humans; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Quinazolines; Rats; Structure-Activity Relationship; Tuberculosis | 2013 |
Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Neuroblastoma; Neurons; Proto-Oncogene Proteins c-myc; Quinazolines; Resting Phase, Cell Cycle | 2013 |
Cu-catalyzed synthesis of tryptanthrin derivatives from substituted indoles.
Topics: Catalysis; Copper; Indoles; Molecular Structure; Oxidation-Reduction; Quinazolines | 2013 |
Aryne insertion reactions leading to bioactive fused quinazolinones: diastereoselective total synthesis of cruciferane.
Topics: Biological Products; Molecular Structure; Quinazolines; Quinazolinones; Stereoisomerism | 2013 |
Amino acid salts catalyzed asymmetric aldol reaction of tryptanthrin: a straightforward synthesis of phaitanthrin A and its derivatives.
Topics: Aldehydes; Amino Acids; Catalysis; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Plants, Medicinal; Quinazolines; Salts; Stereoisomerism | 2013 |
Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lung Neoplasms; Mice; Molecular Structure; Quinazolines; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2013 |
Novel computational study on π-stacking to understand mechanistic interactions of Tryptanthrin analogues with DNA.
Topics: Computer Simulation; DNA; Models, Chemical; Models, Molecular; Molecular Structure; Quinazolines | 2014 |
Tryptanthrin ameliorates atopic dermatitis through down-regulation of TSLP.
Topics: Animals; Calcimycin; Calcium Ionophores; Cell Line; Cytokines; Dermatitis, Atopic; Dinitrofluorobenzene; Down-Regulation; Humans; Male; Mast Cells; Mice; Quinazolines; Skin; Spleen; Tetradecanoylphorbol Acetate; Thymic Stromal Lymphopoietin | 2014 |
Tryptanthrin inhibits angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway.
Topics: Angiogenesis Inhibitors; Animals; Cell Line; Cell Proliferation; Drugs, Chinese Herbal; Endothelial Cells; Humans; MAP Kinase Signaling System; Mice; Neovascularization, Pathologic; Quinazolines; Vascular Endothelial Growth Factor Receptor-2; Wound Healing | 2013 |
The uremic toxin indoxyl sulfate acts as a pro- or antioxidant on LDL oxidation.
Topics: Amidines; Antioxidants; Atherosclerosis; Copper; Hemin; Humans; Hydrogen Peroxide; Indican; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Oxidation-Reduction; Oxidative Stress; Peroxidase; Quinazolines; Renal Insufficiency, Chronic; Uremia | 2014 |
Distribution study of tryptanthrin in rat tissues by HPLC and its relationship with meridian tropism of indigo naturalis in traditional Chinese medicine.
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Linear Models; Meridians; Quinazolines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution | 2014 |
Tryptanthrin protects hepatocytes against oxidative stress via activation of the extracellular signal-regulated kinase/NF-E2-related factor 2 pathway.
Topics: Drugs, Chinese Herbal; Enzyme Activation; Hep G2 Cells; Hepatocytes; Humans; MAP Kinase Signaling System; NF-E2-Related Factor 2; Oxidative Stress; Quinazolines | 2014 |
The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells.
Topics: Apoptosis; Blotting, Western; Caspases; Cell Proliferation; Flavonoids; Flow Cytometry; Gene Expression Regulation; Gene Silencing; HL-60 Cells; Humans; Immunoprecipitation; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Quinazolines; RNA, Small Interfering; STAT3 Transcription Factor | 2014 |
DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apocynaceae; Apoptosis; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Humans; Melanoma; Mice, Inbred NOD; Mice, SCID; Neoplasm Metastasis; Neovascularization, Pathologic; Plant Extracts; Plant Leaves; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2015 |
An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin.
Topics: Aldehydes; Biological Products; Catalysis; Chemistry, Organic; Ethers; Halogenation; Magnetic Resonance Spectroscopy; Quinazolines; Silanes | 2015 |
Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells.
Topics: Acanthaceae; Angiogenesis Inhibitors; Animals; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cell Survival; Chick Embryo; Chorioallantoic Membrane; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Humans; Oncogene Protein v-akt; Quinazolines; Signal Transduction; Vascular Endothelial Growth Factor A | 2015 |
Photophysical Properties of the 2-Hydroxytryptanthrin and Its Sodium Salt as Near-infrared Dyes for Fluorescent Imaging.
Topics: Diagnostic Imaging; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Photochemistry; Quinazolines; Quinazolinones; Salts; Sodium; Solvents; Spectrometry, Fluorescence; Spectroscopy, Near-Infrared; Water | 2016 |
Tryptanthrin reduces mast cell proliferation promoted by TSLP through modulation of MDM2 and p53.
Topics: Apoptosis; Caspase 3; Cell Proliferation; Cytokines; Gene Expression Regulation; Humans; Interleukin-13; Ki-67 Antigen; Mast Cells; Proto-Oncogene Proteins c-mdm2; Quinazolines; Receptors, Cytokine; Receptors, Interleukin-7; RNA, Messenger; Thymic Stromal Lymphopoietin; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2016 |
Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin.
Topics: Animals; Blood-Brain Barrier; Cell Line; Chromatography, High Pressure Liquid; Humans; Isatis; Male; Molecular Structure; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley | 2016 |
Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone.
Topics: Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Cell Membrane Permeability; Chromatography, High Pressure Liquid; HEK293 Cells; Humans; Indoles; Intestinal Absorption; Isatis; Pyrogallol; Quinazolines; Tandem Mass Spectrometry | 2016 |
Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors.
Topics: Clinical Enzyme Tests; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inhibitory Concentration 50; Quinazolines; Recombinant Proteins | 2016 |
Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Copper; Histidine; Ionic Liquids; Molecular Structure; Peptides; Quinazolines; Triazoles | 2016 |
Novel substituted hydrazono indolo[2,1-b]quinazoline-6,12-dione analogues as cytostatic agents: Synthesis, crystal structure, biological evaluation and molecular docking studies.
Topics: A549 Cells; Anti-Infective Agents; Antineoplastic Agents; Bacteria; Bacterial Infections; Fungi; HEK293 Cells; HeLa Cells; Humans; Hydrazones; Indoleamine-Pyrrole 2,3,-Dioxygenase; MCF-7 Cells; Microbial Sensitivity Tests; Molecular Docking Simulation; Mycoses; Quinazolines; Structure-Activity Relationship | 2016 |
In vitro anti-MRSA activity of Couroupita guianensis extract and its component Tryptanthrin.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Brazil; Chlorocebus aethiops; Flowers; Fungi; Lecythidaceae; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microscopy, Electron, Transmission; Plant Extracts; Plants, Medicinal; Quinazolines; Vero Cells | 2017 |
An I
Topics: Acetophenones; Benzamides; Heterocyclic Compounds, 2-Ring; Hydrazines; Iodine; Molecular Structure; Quinazolines | 2017 |
Tryptanthrin prevents oxidative stress-mediated apoptosis through AMP-activated protein kinase-dependent p38 mitogen-activated protein kinase activation.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Arachidonic Acid; Dose-Response Relationship, Drug; Glutathione; Hep G2 Cells; Humans; Iron; Male; Mice; Mice, Inbred ICR; Mitochondria; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protective Agents; Quinazolines; Reactive Oxygen Species | 2017 |
4(3H)-Quinazolone regulates innate immune signaling upon respiratory syncytial virus infection by moderately inhibiting the RIG-1 pathway in RAW264.7 cell.
Topics: Animals; Antiviral Agents; Immunity, Innate; Interferon-beta; Isatis; Macrophages; Medicine, Chinese Traditional; Membrane Proteins; Mice; Nerve Tissue Proteins; Oxazolidinones; Plant Roots; Quinazolines; Quinazolinones; RAW 264.7 Cells; Receptors, Cell Surface; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Ribavirin; Signal Transduction | 2017 |
New insight into the action of tryptanthrins against Plasmodium falciparum: Pharmacophore identification via a novel submolecular QSAR descriptor.
Topics: Antimalarials; Drug Design; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Quinazolines | 2018 |
Anti-neuroinflammatory effects of tryptanthrin from Polygonum tinctorium Lour. in lipopolysaccharide-stimulated BV2 microglial cells.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Lipopolysaccharides; Mice; Microglia; Plant Leaves; Polygonum; Quinazolines | 2018 |
Tryptanthrin Protects Mice against Dextran Sulfate Sodium-Induced Colitis through Inhibition of TNF-α/NF-κB and IL-6/STAT3 Pathways.
Topics: Animals; Colitis; Dextran Sulfate; Interleukin-6; Male; Mice; NF-kappa B; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2018 |
Low-dose action of tryptanthrin and its derivatives against developing embryos of the sea urchin Strongylocentrotus intermedius.
Topics: Animals; Embryo, Nonmammalian; Embryonic Development; Environmental Monitoring; Male; Quinazolines; Spermatozoa; Strongylocentrotus; Water Pollutants, Chemical | 2018 |
Isolation of Tryptanthrin and Reassessment of Evidence for Its Isobaric Isostere Wrightiadione in Plants of the Wrightia Genus.
Topics: Antitubercular Agents; Apocynaceae; Carbon-13 Magnetic Resonance Spectroscopy; Isoflavones; Mass Spectrometry; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Proton Magnetic Resonance Spectroscopy; Quinazolines | 2019 |
A Highly Selective and Sensitive Colorimetric Probe for Cu
Topics: Color; Colorimetry; Copper; Fluorescent Dyes; Limit of Detection; Linear Models; Quinazolines; Water | 2018 |
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.
Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; HEK293 Cells; Humans; Molecular Structure; Quinazolines; Recombinant Proteins; Structure-Activity Relationship; Tryptophan Oxygenase | 2018 |
Ecological Roles of Tryptanthrin, Indirubin and N-Formylanthranilic Acid in Isatis indigotica: Phytoalexins or Phytoanticipins?
Topics: Alternaria; Antifungal Agents; Ascomycota; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Indoles; Isatis; Microbial Sensitivity Tests; Molecular Structure; ortho-Aminobenzoates; Quinazolines; Structure-Activity Relationship | 2019 |
Tryptanthrin Analogues as Inhibitors of Enoyl-acyl Carrier Protein Reductase: Activity against Mycobacterium tuberculosis, Toxicity, Modeling of Enzyme Binding.
Topics: Animals; Antitubercular Agents; Bacterial Proteins; Binding Sites; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Male; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Docking Simulation; Mycobacterium tuberculosis; Quinazolines; Structure-Activity Relationship; Toxicity Tests | 2019 |
The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells.
Topics: Angiogenesis Inhibitors; Apelin; Apelin Receptors; Flavonoids; Gene Expression Regulation; Half-Life; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Signaling Peptides and Proteins; Promoter Regions, Genetic; Quinazolines; RNA Stability; RNA, Messenger; Signal Transduction; Wortmannin | 2019 |
Nano-encapsulated tryptanthrin derivative for combined anticancer therapy via inhibiting indoleamine 2,3-dioxygenase and inducing immunogenic cell death.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Female; HeLa Cells; Humans; Immunogenic Cell Death; Indoleamine-Pyrrole 2,3,-Dioxygenase; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanocapsules; Neoplasms; Polyesters; Quinazolines; Tumor Burden | 2019 |
A Biomimetic, One-Step Transformation of Simple Indolic Compounds to
Topics: Alkaloids; Biomimetics; Hydrogen Peroxide; Indoles; Malassezia; Molecular Structure; Quinazolines; Receptors, Aryl Hydrocarbon | 2019 |
Pre-clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer.
Topics: Animals; Drug Screening Assays, Antitumor; gamma-Aminobutyric Acid; Ki-67 Antigen; Mice; Neoplasm Proteins; Proliferating Cell Nuclear Antigen; Quinazolines; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2020 |
Tryptanthrin, a potential biofilm inhibitor against toxigenic
Topics: Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Cell Survival; Cholera; HEK293 Cells; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Quinazolines; Quorum Sensing; Vibrio cholerae | 2019 |
Tryptanthrin promotes keratinocyte and fibroblast responses in vitro after infection with Trichophyton benhamiae DSM6916.
Topics: Antimicrobial Cationic Peptides; Cell Line; Cytokines; Epidermis; Fibroblasts; Humans; Immunity, Innate; Inflammation; Keratinocytes; Ki-67 Antigen; Quinazolines; Skin; Tinea; Toll-Like Receptor 2; Trichophyton | 2020 |
The anti-TH17 polarization effect of Indigo naturalis and tryptanthrin by differentially inhibiting cytokine expression.
Topics: Animals; Cell Proliferation; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Endothelial Cells; Humans; I-kappa B Kinase; Immunosuppressive Agents; Inflammation Mediators; Jurkat Cells; Keratinocytes; Mice, Knockout; Nuclear Receptor Subfamily 1, Group F, Member 3; Phenotype; Psoriasis; Quinazolines; Skin; Th17 Cells; U937 Cells | 2020 |
Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase.
Topics: Drug Design; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inhibitory Concentration 50; Quinazolines; Solubility; Structure-Activity Relationship; Tryptophan Oxygenase | 2020 |
Isolation and Antibacterial Activity of Indole Alkaloids from
Topics: Anti-Bacterial Agents; Bacteria; Humans; Indole Alkaloids; Indoles; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Quinazolines | 2020 |
Design, synthesis and biomedical evaluation of mostotrin, a new water soluble tryptanthrin derivative.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Female; HCT116 Cells; Humans; K562 Cells; MCF-7 Cells; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Quinazolines; Structure-Activity Relationship; Water | 2020 |
Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Quinazolines; Tumor Microenvironment | 2021 |
Tryptanthrin suppresses double-stranded RNA-induced CXCL10 expression via inhibiting the phosphorylation of STAT1 in human umbilical vein endothelial cells.
Topics: Cells, Cultured; Chemokine CXCL10; DEAD Box Protein 58; Human Umbilical Vein Endothelial Cells; Humans; Interferon Regulatory Factor-3; Interferon-beta; Interferon-Induced Helicase, IFIH1; Phosphorylation; Poly I-C; Quinazolines; RNA, Double-Stranded; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; Toll-Like Receptor 3 | 2021 |
Tryptanthrin Regulates Vascular Smooth Muscle Cell Phenotypic Switching in Atherosclerosis by AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Signaling Pathway.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Atherosclerosis; Becaplermin; Cell Plasticity; Cells, Cultured; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Phenotype; Phosphorylation; Plaque, Atherosclerotic; Quinazolines; Signal Transduction | 2021 |
Tryptanthrin derivatives as efficient singlet oxygen sensitizers.
Topics: Indigo Carmine; Quinazolines; Singlet Oxygen; Solvents | 2022 |
Tryptanthrin attenuates TLR3-mediated STAT1 activation in THP-1 cells.
Topics: Anti-Inflammatory Agents; Humans; Interferon Regulatory Factor-3; Interferon-beta; Janus Kinases; Ligands; Lipopolysaccharides; Poly I-C; Quinazolines; RNA, Messenger; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate; THP-1 Cells; Toll-Like Receptor 3 | 2022 |
Green synthesis and antibacterial evaluation of spiro fused tryptanthrin-thiopyrano[2,3-b]indole hybrids targeting drug-resistant S. aureus.
Topics: Animals; Anti-Bacterial Agents; Indoles; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Quinazolines; Rats; Staphylococcus aureus | 2022 |