quinazolines has been researched along with trimetrexate in 168 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 104 (61.90) | 18.7374 |
| 1990's | 55 (32.74) | 18.2507 |
| 2000's | 8 (4.76) | 29.6817 |
| 2010's | 1 (0.60) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ohnuma, T; Takemura, Y | 1 |
| Fleming, GF; Schilsky, RL | 1 |
| Gaumont, Y; Greco, WR; Kisliuk, RL; Parsons, JC | 1 |
| Girard, PM; Saimot, AG | 1 |
| Assaraf, YG; Schimke, RT; Sharma, RC | 1 |
| Miyachi, H; Ohnuma, T; Sekiguchi, S; Takemura, Y | 1 |
| Bezirdjian, L; Curley, T; Dershaw, DD; Engstrom, C; Fitzpatrick, K; Geller, N; Lin, SY; Nisselbaum, J; Scher, HI; Schwartz, M | 1 |
| Aschele, C; Bertino, JR; Nicolin, A; Rosso, R; Sobrero, A | 1 |
| Arkin, H; Holland, JF; Ohnuma, T; Schwartz, GK | 1 |
| Goldman, ID; Mikulecky, DC; Rape, TJ; Seither, RL; Trent, DF | 2 |
| Goldman, ID; Seither, RL; Trent, DF | 2 |
| Comis, RL; Hudes, GR; LaCreta, F; Litwin, S; O'Dwyer, PJ; Tinsley, P; Walczak, J | 1 |
| Carey, RW; Clamon, GH; Costanza, ME; Dawson, NA; Korzun, AH; Norton, L; Pollak, M; Vogelzang, NJ | 1 |
| Antman, KH; Gonin, R; Licht, JD | 1 |
| Bertino, JR; Lin, JT | 3 |
| Ariyoshi, H; Furue, H; Hasegawa, K; Majima, H; Nakao, I; Niitani, H; Ohta, K; Taguchi, T; Tsukagoshi, S; Yasutomi, M | 1 |
| Huan, SD; Krakoff, IH; Legha, SS; Raber, MN | 1 |
| Bertino, JR; Chang, YM; Li, WW; Lin, JT; Schweitzer, B | 1 |
| Diasio, RB; Stagg, MP | 1 |
| Akman, S; Carr, B; Doroshow, J; Goldberg, D; Grove, W; Leong, L; Margolin, K; Odujinrin, O | 1 |
| Akil, B; Allegra, CJ; Feinberg, J; Hughlett, C; Lane, HC; Ogata-Arakaki, D; Sattler, FR; Shelhamer, J; Tuazon, CU; Verdegem, TD | 1 |
| Cairncross, JG; Eisenhauer, EA; Kerr, IG; MacCormick, RE; Macdonald, DR; Moore, MJ; Rathbone, MP; Sawka, CA | 1 |
| Farber, MS; Garabedian-Ruffalo, SM | 1 |
| Bullen, WW; Chang, T; Whitfield, LR | 1 |
| Bertino, JR | 2 |
| Davey, RT; Masur, H | 1 |
| Bagshawe, KD; Bradshaw, T; Mellor, B; Melton, RG; Pedley, RB; Searle, F; Sherwood, RF | 1 |
| Bodurtha, AJ; Eisenhauer, EA; Iscoe, NA | 1 |
| Matherly, LH; Muench, SP | 1 |
| Assaraf, YG; Molina, A; Schimke, RT; Sherwood, SW | 1 |
| Allegra, CJ; Balis, F; Brooks, J; Curt, GA; Drake, JC; Jenkins, J; Thomas, R; Weiss, RB | 1 |
| Brown, TD; Costanza, ME; Grem, JL; King, SA | 1 |
| Alvarado, C; Dubowy, R; Kamen, B; Pappo, A; Rao, S; Ravindranath, Y; Vega, R; Vietti, T; Whitehead, VM | 1 |
| Faber, HJ; Sprenger, HG; Weits, J | 1 |
| LaCreta, FP; Tinsley, PW | 1 |
| Fry, DW | 1 |
| Abbruzzese, JL; Ajani, JA; Boman, BM; Faintuch, JS; Jackson, DE; Krakoff, IH; Levin, B; Patt, YZ | 1 |
| Carlson, RW; Doroshow, JH; Flam, MS; Lamborn, KR; Malec, M; Odujinrin, OO | 1 |
| Balinska, M; Bunni, M; Galivan, J; Maley, F; Maley, GF; Priest, DG; Rhee, MS | 1 |
| Kajanti, M; Kinnula, V; Maasilta, P; Mattson, K; Niiranen, A | 1 |
| Maasilta, PK; Mattson, KV; Mattson, MT; Rautonen, JK | 1 |
| De Groot, R; Neijens, HJ; Smit, MJ; Van der Voort, E; Van Dongen, JJ; Whitfield, LR | 1 |
| Barlowe, CK; Goldman, ID; Matherly, LH | 1 |
| Allegra, CJ; Baram, J; Drake, JC; Hoang, K; Yeh, GC | 1 |
| Bartlett, MS; Durkin, MM; Jay, MA; Queener, SF; Smith, JW | 1 |
| Cashmore, AR; Coronnello, M; Dreyer, RN; Lin, JT; Mazzei, T; McGuire, JJ; Mini, E; Moroson, BA; Periti, P; Pizzorno, G | 1 |
| Bertino, JR; Chang, YM; McGuire, JJ; Pizzorno, G | 1 |
| Dykes, DJ; Elliott, WL; Howard, CT; Leopold, WR | 1 |
| Arteaga, CL; Brown, TD; Craig, JB; Harman, GS; Koeller, JM; Kuhn, JG; Von Hoff, DD; Weiss, GR | 1 |
| Gaumont, Y; Kisliuk, RL; Murthy, BR; Nair, MG; Piper, JR; Sirotnak, FM; Thorndike, J | 1 |
| Assaraf, YG; Molina, A; Schimke, RT | 3 |
| Boselli, B; Bosl, G; Dershaw, D; Houston, C; Rosado, K; Rosenbluth, R; Scher, H; Sternberg, CN; Vinciguerra, V; Yagoda, A | 1 |
| Ensminger, WD; Shukla, UA; Stetson, PL | 1 |
| Catalano, R; Comis, RL; DeLap, RJ; Grillo-Lopez, AJ; Hudes, GR; LaCreta, F | 1 |
| Bunni, M; Dilwith, R; Galivan, J; Johnson, TB; Nair, MG; Priest, DG; Rhee, MS | 1 |
| Bishop, JF; Friedlander, ML; Morris, R; Olver, IN; Raghavan, D; Reece, P | 1 |
| Bertino, JR; Nicolin, A; Romanini, A; Rosso, R; Russello, O; Sobrero, A | 1 |
| Allegra, CJ; Beaver, J; Boarman, D; Chabner, B; Kovacs, JA; Lewis, M; Masur, H; Parrillo, JE | 1 |
| Appelbaum, FR; Deeg, HJ; Graham, TC; Raff, RF; Sandmaier, B; Schuening, F; Storb, R | 1 |
| Bertino, JR; Chou, TC; Romanini, A; Sherwood, RF; Sobrero, AF | 1 |
| Chastang, C; Derouin, F | 1 |
| Jansen, G; Rijksen, G; Schornagel, JH; van der Veer, LJ; Westerhof, GR | 1 |
| Bertino, JR; Chou, TC; Romanini, A | 1 |
| Montgomery, AB | 1 |
| Burke, MT; D'Acquisto, RW; Fanucchi, MP; Gralla, RJ; Heelan, RT; Kris, MG; Marks, LD | 1 |
| Arkin, H; Holland, JF; Kamen, BA; Ohnuma, T; Vallabhajosula, S | 1 |
| Donehower, RC; Ettinger, DS; Grochow, LB; Noe, DA | 1 |
| Maroun, J | 1 |
| Grove, W; Holsti, LR; Maasilta, P; Mattson, K; Tammilehto, L | 1 |
| Maroun, JA; Natale, RB; Robert, F | 1 |
| Goldman, ID; Matherly, LH; Schuetz, JD; Westin, EH | 1 |
| Nightingale, SL; Young, FE | 1 |
| McCormack, JJ; Tong, WP; Webster, LK | 2 |
| Dole, GB; Donehower, RC; Ettinger, DS; Graham, ML; Grochow, LB; McGuire, WP; Noe, DA; Rowinsky, EK | 1 |
| Balis, FM; Lester, CM; Poplack, DG | 1 |
| Griswold, DP; Hook, KE; Leopold, WR; Nelson, JM; Roberts, BJ | 1 |
| Bertino, JR; Sobrero, AF | 1 |
| Besserer, JA; Fry, DW; Klohs, WD; Steinkampf, RW | 1 |
| Holland, JF; Kano, Y; Ohnuma, T | 1 |
| Allegra, CJ; Curt, GA; James, WD; Major, WB; Porter, MB; Weiss, RB | 1 |
| Bertino, JR; McGuire, JJ; Narayanan, R; Rodenhuis, S | 1 |
| McCormack, JJ; Webster, LK | 1 |
| Baker, M; Bertino, JR; Cashmore, AR; Delap, R; Dreyer, RN; Ernstoff, M; Grillo-Lopez, A; Lin, JT; Marsh, JC; Whitfield, LR | 1 |
| Allegra, CJ; Chabner, BA; Drake, JC; Kovacs, JA; Masur, H; Swan, JC | 2 |
| Ensminger, WD; Stetson, PL | 1 |
| Allegra, CJ; Chabner, BA; Drake, J; Kovacs, JA; Lunde, M; Masur, H; Parrillo, JE; Swan, JC | 1 |
| Bishop, JF; Morris, RG; Olver, IN; Raghavan, D; Reece, PA | 1 |
| Cassidy, C; Chou, TC; Fanucchi, MP; Fleisher, M; Lokos, G; Niedzwiecki, D; Vidal, P; Walsh, TD; Williams, L; Young, CW | 1 |
| Branda, RF; Carney, JK; McCormack, JJ; Moore, AL; Perlmutter, CA | 1 |
| Balis, FM; Belasco, J; Doherty, KM; Ettinger, LJ; Holcenberg, JS; Luks, E; Patel, R; Reaman, GH; Tan, C; Zimm, S | 1 |
| Covington, WP; Ho, DH; Krakoff, IH; Legha, SS; Newman, RA | 1 |
| Galivan, J; Nimec, Z; Rhee, M | 1 |
| Cody, V; Sutton, PA | 1 |
| Hughes, WT | 1 |
| Allegra, CJ; Baird, B; Balis, F; Chabner, BA; Drake, JC; Lack, EE; Ogata-Arakaki, D; Shelhamer, JH; Simmons, JT; Tuazon, CU | 1 |
| Eisenhauer, E; Jolivet, J; Landry, L; McCormack, JJ; Pinard, MF; Tong, WP | 1 |
| Bertino, JR; McGuire, JJ; Rodenhuis, S; Sawicki, WL | 1 |
| Ackermann, MF; Germolec, DR; Lamm, KR; Luster, MI; Rosenthal, GJ | 1 |
| DeLap, RJ; Grillo-Lopez, AJ; Hoth, DF; King, SA; Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Dykes, DJ; Griswold, DP; Leopold, WR | 1 |
| Boschelli, D; Galivan, J; Kerwar, SS; Nimec, Z; Oronsky, AL; Rhee, M | 1 |
| Allegra, CJ; Balis, FM; Chabner, BA; Drake, JC; Lane, HC; Masur, H; Murphy, RF; Parrillo, JE; Poplack, DG; Rogers, P | 1 |
| Fry, DW; Hamelehle, KL; Jackson, RC; Leopold, WR | 1 |
| Stewart, JA | 1 |
| Robert, F | 1 |
| Leiby, JM | 1 |
| Comis, RL; Hudes, GR | 1 |
| Allegra, CJ; Baird, B; Chabner, BA; Drake, JC; Masur, H; Ogata-Arakaki, D; Tuazon, CU | 1 |
| Bertino, JR; Cashmore, AR; Fanucchi, MP; Lin, JT; McCormack, JJ; Stewart, JA; Tong, WP | 1 |
| Allegra, CJ; Chabner, BA; Drake, JC; Kovacs, JA; Masur, H; Parrillo, JE; Swan, JC | 1 |
| Blank, JA; Germolec, DR; Luster, MI; Rosenthal, GJ; Weigand, GW | 1 |
| Kovacs, JA; Masur, H | 1 |
| Blow, A; Grove, WR; Haugh, LD; Lopez, AJ; Low, JB; McCormack, JJ; Roberts, JD; Stewart, JA; Tong, W; Whitfield, LR | 1 |
| Donehower, RC | 1 |
| Ellenberg, SS; Grem, JL; King, SA; Shoemaker, DD | 1 |
| Eisenhauer, EA; Pater, JL; Walsh, WR; Zee, BC | 1 |
| Besserer, JA; Fry, DW | 1 |
| Allegra, CJ; Chabner, B; Drake, J; Kennedy, S; Kovacs, JA; Masur, H; Parrillo, JE; Swan, JC | 1 |
| Camerman, A; Camerman, N; Hempel, A | 1 |
| Fischl, MA | 1 |
| Alberts, AS; Badata, M; Falkson, G; Schmid, EU; Terblanche, AP | 1 |
| Cradock, J; Grillo-Lopez, A; Leyland-Jones, B; O'Dwyer, PJ; Plowman, J; Shoemaker, DD | 1 |
| Franklin, MR; Heusner, JJ | 1 |
| Allegra, CJ; Chabner, BA; Curt, GA; Drake, JC | 1 |
| Diddens, H; Jackson, RC; Niethammer, D | 2 |
| Elslager, EF; Johnson, JL; Werbel, LM | 1 |
| Elslager, E; Lathan, B; Von Hoff, DD | 1 |
| Bertino, J; Cashmore, A; Eibl, B; Kamen, BA | 1 |
| Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ | 1 |
| Heusner, JJ; McCormack, JJ | 1 |
| Marsh, JC | 1 |
| Bertino, JR; Cashmore, AR; Dreyer, RN; Graham, ML; Hsiao, N; Moroson, BA; Sawicki, WL; Weir, EC | 1 |
| Baccanari, DP; Boytos, CM; Chan, JH; Hong, JS; Joyner, SS; Kuyper, LF; Rudolph, SK; Tansik, RL | 1 |
| Bagnara, AS; Nott, SE | 1 |
| Ando, K; Ando, Y; Kobayashi, H; Miyachi, H; Takemura, Y | 1 |
| Jackman, AL; Kobayashi, H; Miyachi, H; Skelton, L; Takemura, Y | 1 |
| Hanauske, AR | 1 |
| Allegra, CJ; Takimoto, CH | 1 |
| Borud, K; Isacoff, WH | 1 |
| Kamen, B | 1 |
| Loriga, M; Paglietti, G; Vitale, G | 1 |
| Corona, P; Loriga, M; Paglietti, G; Vitale, G | 1 |
| Punt, CJ | 1 |
| Creutzig, U; Hählen, K; Janka-Schaub, G; Jansen, G; Kaspers, GJ; Mauritz, R; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ; Willey, JC | 1 |
| Strømhaug, A; Warren, DJ | 1 |
| Assaraf, YG; Drori, S; Jansen, G; Mauritz, R; Peters, GJ | 1 |
| Holen, KD; Saltz, LB | 1 |
| Faessel, HM; Greco, WR; Rustum, YM; Slocum, HK | 1 |
| Brun, Y; Greco, WR; Slocum, HK; White, DB; Wrzosek, C | 1 |
| Banerjee, D; Bertino, JR; Li, WW; Magro, PG; Russo, AJ | 1 |
| Goldman, ID; Wang, Y; Zhao, R | 1 |
| Assaraf, YG; Berman, B; Bram, E; Ifergan, I; Jansen, G; Shafran, A | 1 |
| Assaraf, YG; Dijkmans, BA; Gerards, AH; Jansen, G; Lems, WF; Oerlemans, R; Scheper, RJ; van der Heijden, JW | 1 |
18 review(s) available for quinazolines and trimetrexate
| Article | Year |
|---|---|
Antifolates: the next generation.
Topics: Aminopterin; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Drug Evaluation; Folic Acid Antagonists; Forecasting; Humans; Neoplasms; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 1992 |
[Pneumocystis carinii pneumonia in HIV infection. Diagnosis, prognostic factors and curative treatment].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; CD4-Positive T-Lymphocytes; Dapsone; Eflornithine; Folic Acid Antagonists; HIV Infections; Humans; Pentamidine; Pneumonia, Pneumocystis; Prognosis; Quinazolines; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1991 |
Update on trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Antiprotozoal Agents; Clinical Trials as Topic; Drug Resistance; Female; Folic Acid Antagonists; Humans; Male; Middle Aged; Neoplasms, Experimental; Quinazolines; Trimetrexate | 1991 |
Novel chemotherapeutic agents in early clinical development.
Topics: Adenine; Alkaloids; Anthraquinones; Antineoplastic Agents; Biphenyl Compounds; Camptothecin; Humans; Imides; Irinotecan; Isoquinolines; Naphthalimides; Neoplasms; Organophosphonates; Paclitaxel; Pyrazoles; Quinazolines; Sulfonylurea Compounds; Terpenes; Trimetrexate | 1990 |
Recent advances in the diagnosis, treatment, and prevention of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Antineoplastic Agents; Humans; Opportunistic Infections; Pneumonia, Pneumocystis; Quinazolines; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1990 |
New anticancer agents.
Topics: Acetamides; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Flavonoids; Gallium; Humans; Mitolactol; Mitoxantrone; Organoplatinum Compounds; Pentostatin; Quinazolines; Ribavirin; Trimetrexate; Vidarabine Phosphate | 1987 |
Recent developments in the therapy and management of Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Dapsone; Drug Therapy, Combination; Humans; Pentamidine; Pneumonia, Pneumocystis; Quinazolines; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1989 |
Current status of trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties.
Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Drug Evaluation; Folic Acid Antagonists; Humans; Quinazolines; Trimetrexate | 1989 |
Trimetrexate: a second generation folate antagonist in clinical trial.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Humans; Neoplasms; Quinazolines; Trimetrexate | 1987 |
Preclinical studies with trimetrexate: a review of conclusions and unanswered questions.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation, Preclinical; Drug Resistance; Humans; Quinazolines; Trimetrexate | 1988 |
Pneumocystis carinii pneumonia: therapy and prophylaxis.
Topics: Acquired Immunodeficiency Syndrome; Anti-Bacterial Agents; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Pentamidine; Pneumonia, Pneumocystis; Pyrimethamine; Quinazolines; Recurrence; Sulfadiazine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1988 |
Treatment and prophylaxis of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Antiprotozoal Agents; Clinical Trials as Topic; Dapsone; Drug Combinations; Humans; Pentamidine; Pneumonia, Pneumocystis; Quinazolines; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate; Zidovudine | 1988 |
The development of new chemotherapeutic agents.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Deoxycytidine; Gemcitabine; Glutamates; Guanine; Humans; Irinotecan; Neoplasms; Pemetrexed; Quinazolines; Thiophenes; Trimetrexate | 1996 |
New antifolates in clinical development.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Drugs, Investigational; Folic Acid Antagonists; Humans; Neoplasms; Pyrimidines; Quinazolines; Thiophenes; Trimetrexate | 1995 |
Chemotherapy for the treatment of patients with metastatic colorectal cancer: an overview.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Quinazolines; Thiophenes; Thymidylate Synthase; Trimetrexate | 1997 |
Folate and antifolate pharmacology.
Topics: Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Trimetrexate | 1997 |
New drugs in the treatment of colorectal carcinoma.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Topotecan; Trimetrexate; Uracil | 1998 |
New therapies, new directions: advances in the systemic treatment of metastatic colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Forecasting; Humans; Irinotecan; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Trimetrexate; Uracil | 2001 |
12 trial(s) available for quinazolines and trimetrexate
| Article | Year |
|---|---|
Pharmacokinetic study of trimetrexate in combination with cisplatin.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasm Metastasis; Neoplasms; Protein Binding; Quinazolines; Trimetrexate | 1991 |
Trimetrexate in untreated and previously treated patients with metastatic breast cancer: a Cancer and Leukemia Group B study.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Hematologic Diseases; Humans; Liver Neoplasms; Middle Aged; Quinazolines; Trimetrexate | 1991 |
[Phase I study of CI-898. CI-898 Study Group].
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Digestive System Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Quinazolines; Trimetrexate | 1991 |
Phase I studies of trimetrexate using single and weekly dose schedules.
Topics: Adolescent; Adult; Aged; Drug Administration Schedule; Drug Evaluation; Female; Folic Acid Antagonists; Humans; Male; Middle Aged; Quinazolines; Trimetrexate | 1991 |
Novel chemotherapeutic agents in early clinical development.
Topics: Adenine; Alkaloids; Anthraquinones; Antineoplastic Agents; Biphenyl Compounds; Camptothecin; Humans; Imides; Irinotecan; Isoquinolines; Naphthalimides; Neoplasms; Organophosphonates; Paclitaxel; Pyrazoles; Quinazolines; Sulfonylurea Compounds; Terpenes; Trimetrexate | 1990 |
Folate antagonists: toward improving the therapeutic index and development of new analogs.
Topics: Cell Line; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Drug Resistance; Folic Acid Antagonists; Gene Amplification; Humans; Methotrexate; Mutation; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1990 |
Phase II trial of trimetrexate in the treatment of recurrent childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Topics: Adolescent; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Infusions, Intravenous; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Recurrence; Remission Induction; Trimetrexate | 1990 |
A phase II study of trimetrexate therapy for metastatic colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Quinazolines; Trimetrexate | 1990 |
Trimetrexate in locally advanced or metastatic adenocarcinoma of the pancreas. A phase II study of the Northern California Oncology Group.
Topics: Adenocarcinoma; Antineoplastic Agents; Drug Evaluation; Drugs, Investigational; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Pancreatic Neoplasms; Quinazolines; Trimetrexate | 1990 |
Trimetrexate: a second generation folate antagonist in clinical trial.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Humans; Neoplasms; Quinazolines; Trimetrexate | 1987 |
Treatment and prophylaxis of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Antiprotozoal Agents; Clinical Trials as Topic; Dapsone; Drug Combinations; Humans; Pentamidine; Pneumonia, Pneumocystis; Quinazolines; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate; Zidovudine | 1988 |
Trimetrexate: a new antifol entering clinical trials.
Topics: Animals; Biological Availability; Biological Transport; Cells, Cultured; Clinical Trials as Topic; DNA; Dogs; Drug Evaluation, Preclinical; Folic Acid Antagonists; Mice; Neoplasms, Experimental; Nucleosides; Quinazolines; Trimetrexate | 1985 |
141 other study(ies) available for quinazolines and trimetrexate
| Article | Year |
|---|---|
N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
Topics: Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured | 1992 |
Quantitation of folic acid enhancement of antifolate synergism.
Topics: Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid; Folic Acid Antagonists; Humans; Lymphoma; Quinazolines; Tetrahydrofolates; Trimetrexate; Tumor Cells, Cultured | 1992 |
A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Cell Line; Cricetinae; Drug Resistance; Folic Acid Antagonists; Gene Amplification; Membrane Glycoproteins; Methotrexate; Phenotype; Pyrimidines; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate; Verapamil | 1991 |
A human leukemia cell line made resistant to two folate analogues, trimetrexate and N10-propargyl-5,8-dideazafolic acid (CB3717).
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; Cisplatin; Cross Reactions; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Fluorouracil; Folic Acid; Humans; Leucovorin; Membrane Glycoproteins; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; RNA, Messenger; Thymidylate Synthase; Trimetrexate; Vincristine | 1991 |
Trimetrexate in prostatic cancer: preliminary observations on the use of prostate-specific antigen and acid phosphatase as a marker in measurable hormone-refractory disease.
Topics: Acid Phosphatase; Aged; Antigens, Neoplasm; Antineoplastic Agents; Biomarkers, Tumor; Humans; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Neoplasms; Quinazolines; Time Factors; Trimetrexate | 1990 |
Rapid development of resistance to antifolates in vitro: possible clinical implication.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Female; Folic Acid Antagonists; Leukemia P388; Methotrexate; Mice; Quinazolines; Trimetrexate; Tumor Cells, Cultured | 1991 |
Protein kinase C activity and multidrug resistance in MOLT-3 human lymphoblastic leukemia cells resistant to trimetrexate.
Topics: Alkaloids; Cell Division; Drug Resistance; Humans; In Vitro Techniques; Leukemia, Lymphoid; Protein Kinase C; Quinazolines; Staurosporine; Tetradecanoylphorbol Acetate; Trimetrexate; Tumor Cells, Cultured | 1991 |
Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition.
Topics: Animals; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Quinazolines; Quinazolinones; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured | 1991 |
Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Flow Cytometry; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thermodynamics; Trimetrexate; Tumor Cells, Cultured | 1991 |
Phase II trial of trimetrexate in patients with advanced soft-tissue sarcoma.
Topics: Antineoplastic Agents; Drug Evaluation; Folic Acid Antagonists; Humans; Infusions, Intravenous; Quinazolines; Remission Induction; Sarcoma; Soft Tissue Neoplasms; Time Factors; Trimetrexate | 1991 |
Compartmentation of intracellular folates. Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate.
Topics: Animals; Cell Compartmentation; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Mitochondria; Quinazolines; Tetrahydrofolates; Trimetrexate; Tumor Cells, Cultured | 1991 |
Prediction of antifolate efficacy in a rat sarcoma model.
Topics: Aminopterin; Animals; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Male; Methotrexate; Methylcholanthrene; Quinazolines; Rats; Sarcoma, Experimental; Thymidylate Synthase; Trimetrexate | 1991 |
Treatment of metastatic malignant melanoma with trimetrexate: a phase II study.
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Folic Acid Antagonists; Humans; Male; Melanoma; Middle Aged; Quinazolines; Remission Induction; Trimetrexate | 1990 |
Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adult; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Humans; Leucovorin; Male; Pneumonia, Pneumocystis; Quinazolines; Trimetrexate | 1990 |
Phase II study of trimetrexate in recurrent anaplastic glioma. National Cancer Institute of Canada Clinical Trials Group Study.
Topics: Adult; Aged; Antineoplastic Agents; Canada; Drug Evaluation; Female; Glioma; Humans; Injections, Intravenous; Male; Middle Aged; Quinazolines; Trimetrexate | 1990 |
Applying drug-use evaluation principles to investigational or unlabeled drug use.
Topics: Acyclovir; District of Columbia; Drug Evaluation; Drug Utilization; Drugs, Investigational; Hospital Bed Capacity, 500 and over; Pharmacy Service, Hospital; Pilot Projects; Quinazolines; Trimetrexate | 1990 |
High-performance liquid chromatographic assay for trimetrexate in human plasma.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Quinazolines; Trimetrexate | 1990 |
Carboxypeptidase G2 and trimetrexate cause growth delay of human colonic cancer cells in vitro.
Topics: Animals; Antineoplastic Agents; Carboxypeptidases; Cell Division; Colonic Neoplasms; Culture Media; Homocysteine; Humans; Methionine; Mice; Quinazolines; Rabbits; Trimetrexate; Tumor Cells, Cultured | 1990 |
Phase II study of trimetrexate in malignant melanoma: a National Cancer Institute of Canada Clinical Trials Group study.
Topics: Adult; Aged; Drug Administration Schedule; Drug Evaluation; Female; Folic Acid Antagonists; Hematologic Diseases; Humans; Male; Melanoma; Middle Aged; Quinazolines; Trimetrexate | 1990 |
Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Mice; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimetrexate; Tumor Cells, Cultured | 1990 |
Flow cytometric characterization of antifolate resistance in cultured mammalian cells using fluoresceinated methotrexate and daunorubicin.
Topics: Animals; Cell Line; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Female; Flow Cytometry; Folic Acid Antagonists; Kinetics; Methotrexate; Ovary; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Verapamil | 1990 |
A phase I and pharmacokinetic study of trimetrexate using a 24-hour continuous-injection schedule.
Topics: Adult; Aged; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Evaluation; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Quinazolines; Trimetrexate | 1990 |
Hypersensitivity reactions to trimetrexate.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Drug Evaluation; Drug Hypersensitivity; Female; Folic Acid Antagonists; Humans; Infusions, Intravenous; Male; Middle Aged; Quinazolines; Trimetrexate | 1990 |
Relapse Pneumocystis carinii pneumonitis and adverse reaction to current therapy in patients with AIDS: trimetrexate as an alternative.
Topics: Acquired Immunodeficiency Syndrome; Adult; Folic Acid Antagonists; Humans; Male; Pneumonia, Pneumocystis; Quinazolines; Radiography; Recurrence; Trimetrexate | 1990 |
Improved chromatographic method for the determination of trimetrexate in urine.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Humans; Quinazolines; Trimetrexate | 1990 |
Cytotoxic synergism between trimetrexate and etoposide. Evidence that trimetrexate potentiates etoposide-induced protein-associated DNA strand breaks in L1210 leukemia cells through alterations in intracellular ATP concentrations.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; DNA Damage; DNA, Neoplasm; Etoposide; Leukemia L1210; Mice; Quinazolines; Trimetrexate; Tumor Cells, Cultured | 1990 |
Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells.
Topics: Carcinoma, Hepatocellular; Folic Acid; Liver Neoplasms; Pteroylpolyglutamic Acids; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Trimetrexate; Tumor Cells, Cultured | 1990 |
Phase II study of trimetrexate and cyclophosphamide in previously untreated patients with inoperable non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cyclophosphamide; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Quinazolines; Remission Induction; Trimetrexate | 1990 |
Quality of life assessment during chemotherapy for non-small cell lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cyclophosphamide; Drug Evaluation; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Middle Aged; Quality of Life; Quinazolines; Trimetrexate | 1990 |
Trimetrexate efficacy and pharmacokinetics during treatment of refractory Pneumocystis carinii pneumonia in an infant with severe combined immunodeficiency disease.
Topics: Antifungal Agents; Drug Combinations; Glucuronates; Humans; Immunologic Deficiency Syndromes; Infant; Infusions, Intravenous; Leucovorin; Male; Pentamidine; Pneumonia, Pneumocystis; Quinazolines; Respiratory Insufficiency; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1990 |
Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.
Topics: Animals; Cell Survival; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimetrexate | 1986 |
Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.
Topics: Acyltransferases; Antineoplastic Agents; Breast Neoplasms; Carbon Radioisotopes; Cell Line; Female; Floxuridine; Folic Acid; Glycine; Humans; Hydroxymethyl and Formyl Transferases; Kinetics; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Polyglutamic Acid; Purines; Quinazolines; Trimetrexate | 1987 |
Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection.
Topics: Animals; Cells, Cultured; Folic Acid Antagonists; Humans; Pneumocystis; Pneumonia, Pneumocystis; Pyrimidines; Quinazolines; Rats; RNA; Trimetrexate | 1987 |
Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug.
Topics: Drug Resistance; Humans; Methotrexate; Peptides; Polyglutamic Acid; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured | 1988 |
Inherent resistance of human squamous carcinoma cell lines to methotrexate as a result of decreased polyglutamylation of this drug.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Resistance; Head and Neck Neoplasms; Humans; Methotrexate; Peptide Synthases; Peptides; Polyglutamic Acid; Quinazolines; Thymidylate Synthase; Time Factors; Trimetrexate; Tumor Cells, Cultured | 1989 |
Sequence and schedule-dependent synergy of trimetrexate in combination with 5-fluorouracil in vitro and in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; Cricetinae; Drug Administration Schedule; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Leukemia P388; Mice; Phosphoribosyl Pyrophosphate; Quinazolines; Trimetrexate | 1989 |
AIDS drug available.
Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Glucuronates; Humans; Pneumonia, Pneumocystis; Quinazolines; Trimetrexate | 1988 |
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
Topics: Acyltransferases; Animals; Folic Acid; Humans; Hydroxymethyl and Formyl Transferases; Kinetics; Leukemia L1210; Lymphoma; Mice; Molecular Conformation; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Pteroylpolyglutamic Acids; Quinazolines; Structure-Activity Relationship; Trimetrexate | 1989 |
Trimetrexate for Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Humans; Leucovorin; Leukopenia; Pneumonia, Pneumocystis; Quinazolines; Trimetrexate | 1989 |
Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line; Drug Resistance; Female; Genes; Humans; Methotrexate; Ovarian Neoplasms; Phenotype; Quinazolines; Quinidine; RNA, Messenger; Trimetrexate; Tumor Cells, Cultured; Verapamil | 1989 |
Phase II trial of trimetrexate in patients with advanced renal cell carcinoma. Clinical Community Oncology Program.
Topics: Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Evaluation; Folic Acid Antagonists; Humans; Kidney Neoplasms; Middle Aged; Quinazolines; Trimetrexate | 1989 |
Stability of trimetrexate, a new non-classical antifolate, in infusion solutions.
Topics: Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Kinetics; Quinazolines; Spectrophotometry, Ultraviolet; Trimetrexate | 1989 |
Phase I clinical and pharmacologic trial of trimetrexate in combination with 5-fluorouracil.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Blood Proteins; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Mouth Mucosa; Neoplasms; Neutropenia; Protein Binding; Quinazolines; Stomatitis; Thrombocytopenia; Trimetrexate | 1989 |
The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Folic Acid; Folic Acid Antagonists; Kinetics; Liver Neoplasms, Experimental; Pyrimethamine; Quinazolines; Rats; Thymidylate Synthase; Trimetrexate | 1989 |
A fluorescein-methotrexate-based flow cytometric bioassay for measurement of plasma methotrexate and trimetrexate levels.
Topics: Flow Cytometry; Fluorescein; Fluoresceins; Humans; Indicators and Reagents; Methotrexate; Quinazolines; Trimetrexate | 1989 |
A phase I study of trimetrexate (NSC 352122) administered by 5-day continuous intravenous infusion.
Topics: Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infusion Pumps; Infusions, Intravenous; Leukocyte Count; Male; Middle Aged; Neoplasms; Neutropenia; Neutrophils; Platelet Count; Quinazolines; Stomatitis; Thrombocytopenia; Trimetrexate | 1989 |
Sequence-dependent enhancement of HCT-8 cell kill by trimetrexate and fluoropyrimidines: implications for the mechanism of this interaction.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colony-Forming Units Assay; Drug Interactions; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Quinazolines; Trimetrexate; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents.
Topics: 4-Aminobenzoic Acid; Animals; Drug Combinations; Drug Evaluation, Preclinical; Folic Acid; Pneumocystis; Quinazolines; Rats; Sulfamethoxazole; Toxoplasma; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1989 |
Use of trimetrexate for the prevention of graft-versus-host disease.
Topics: Animals; Antineoplastic Agents; Child; Cyclosporins; Dogs; Drug Combinations; Folic Acid Antagonists; Graft Rejection; Graft vs Host Disease; Humans; Immunosuppressive Agents; Quinazolines; Trimetrexate | 1989 |
Enhancement of trimetrexate cytotoxicity in vitro and in vivo by carboxypeptidase G2.
Topics: Animals; Cell Line; Cell Survival; Clone Cells; Cysteine Endopeptidases; Drug Resistance; Drug Synergism; Folic Acid; gamma-Glutamyl Hydrolase; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Quinazolines; Trimetrexate; Tumor Stem Cell Assay | 1989 |
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
Topics: Animals; Computer Simulation; Deoxyuridine; Floxuridine; Folic Acid; Folic Acid Antagonists; Formates; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimidines; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate | 1989 |
In vitro effects of folate inhibitors on Toxoplasma gondii.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Folic Acid Antagonists; Microbial Sensitivity Tests; Pyrimethamine; Pyrimidines; Quinazolines; Sulfamethoxazole; Sulfisoxazole; Toxoplasma; Trimethoprim; Trimetrexate | 1989 |
Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake.
Topics: Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; In Vitro Techniques; Leucovorin; Leukemia; Methotrexate; Quinazolines; Receptors, Cell Surface; Trimetrexate; Tumor Cells, Cultured | 1989 |
Carboxypeptidase G2 enhances trimetrexate cytotoxicity in CCRF-CEM cell lines sensitive and resistant to methotrexate.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Clone Cells; Cysteine Endopeptidases; Drug Resistance; Drug Synergism; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Quinazolines; Trimetrexate; Tumor Cells, Cultured | 1989 |
Phase II trial of trimetrexate in patients with stage III and IV non-small-cell lung cancer.
Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Quinazolines; Trimetrexate | 1989 |
Sequential amplification of dihydrofolate reductase and multidrug resistance genes in Chinese hamster ovary cells selected for stepwise resistance to the lipid-soluble antifolate trimetrexate.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cricetinae; Drug Resistance; Fluorescein; Fluoresceins; Folic Acid Antagonists; Gene Amplification; Gene Expression; Membrane Glycoproteins; Methotrexate; Pyrimidines; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1989 |
Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Doxorubicin; Drug Resistance; Humans; In Vitro Techniques; Leukemia; Membrane Glycoproteins; Methotrexate; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured; Verapamil; Vincristine | 1989 |
A phase I trial of trimetrexate glucuronate (NSC 352122) given every 3 weeks: clinical pharmacology and pharmacodynamics.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation; Female; Glucuronates; Humans; Infusions, Intravenous; Leukopenia; Male; Middle Aged; Neoplasms; Quinazolines; Time Factors; Trimetrexate | 1989 |
Clinical response to trimetrexate as sole therapy for nonsmall cell lung cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Quinazolines; Trimetrexate | 1988 |
Trimetrexate and cyclophosphamide for metastatic inoperable nonsmall cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cyclophosphamide; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Quinazolines; Trimetrexate | 1988 |
Trimetrexate combined with cisplatin or etoposide in the treatment of non-small cell lung cancer: a pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carcinoma, Non-Small-Cell Lung; Cisplatin; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Quinazolines; Trimetrexate | 1988 |
Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Membrane; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Gene Amplification; Leucovorin; Leukemia L1210; Methotrexate; Mice; Phenotype; Quinazolines; Receptors, Cell Surface; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimetrexate | 1988 |
FDA's newly designated treatment INDs.
Topics: Clinical Protocols; Cytomegalovirus; Cytomegalovirus Infections; Drug Combinations; Drug Therapy, Combination; Glucuronates; Humans; Immune Sera; Immunoglobulins; Immunoglobulins, Intravenous; Kidney Transplantation; Leucovorin; Pneumonia, Pneumocystis; Quinazolines; Trimetrexate; United States; United States Food and Drug Administration | 1988 |
Effect of trimethoprim, paracetamol and cimetidine on trimetrexate metabolism by rat perfused isolated livers.
Topics: Acetaminophen; Animals; Cimetidine; Drug Interactions; Folic Acid Antagonists; In Vitro Techniques; Liver; Male; Quinazolines; Rats; Rats, Inbred Strains; Trimethoprim; Trimetrexate | 1987 |
Phase I trial of trimetrexate glucuronate on a five-day bolus schedule: clinical pharmacology and pharmacodynamics.
Topics: Adult; Aged; Animals; Bone Marrow; Drug Administration Schedule; Drug Combinations; Drug Evaluation; Female; Glucuronates; Humans; Male; Mice; Middle Aged; Neoplasms; Quinazolines; Skin; Species Specificity; Trimetrexate | 1989 |
Metabolism and biliary excretion of trimetrexate by the isolated perfused rat liver.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; Folic Acid Antagonists; Half-Life; Kinetics; Liver; Male; Perfusion; Quinazolines; Rats; Rats, Inbred Strains; Trimetrexate | 1985 |
Pharmacokinetics of trimetrexate (NSC 352122) in monkeys.
Topics: Animals; Folic Acid Antagonists; Macaca mulatta; Male; Metabolic Clearance Rate; Methotrexate; Protein Binding; Quinazolines; Trimetrexate | 1986 |
Cell cycle effects of trimetrexate (CI-898).
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Survival; Cells, Cultured; Cricetinae; Demecolcine; Drug Evaluation, Preclinical; Female; Flow Cytometry; Injections, Intraperitoneal; Interphase; Leukemia L1210; Methotrexate; Mice; Neoplasms, Experimental; Ovary; Quinazolines; Trimetrexate | 1986 |
Endogenous thymidine and hypoxanthine are a source of error in evaluating methotrexate cytotoxicity by clonogenic assays using undialyzed fetal bovine serum.
Topics: Adenocarcinoma; Animals; Cattle; Cell Adhesion; Colonic Neoplasms; Colony-Forming Units Assay; Culture Media; Dose-Response Relationship, Drug; Humans; Hypoxanthines; Leucovorin; Methotrexate; Neoplastic Stem Cells; Quinazolines; Thymidine; Trimetrexate | 1986 |
Cross resistance of pleiotropically drug resistant P338 leukemia cells to the lipophilic antifolates trimetrexate and BW 301U.
Topics: Animals; Drug Resistance; Folic Acid Antagonists; Leukemia P388; Methotrexate; Mice; Pyrimidines; Quinazolines; Trimetrexate | 1986 |
Folate requirements of methotrexate-resistant human acute lymphoblastic leukemia cell lines.
Topics: Biological Transport; Cell Line; Drug Resistance; Folic Acid; Humans; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Nutritional Requirements; Quinazolines; Trimetrexate | 1986 |
Skin reactions induced by trimetrexate, an analog of methotrexate.
Topics: Cellulitis; Dermatitis, Exfoliative; Humans; Quinazolines; Skin Diseases; Trimetrexate | 1986 |
Development of an assay system for the detection and classification of methotrexate resistance in fresh human leukemic cells.
Topics: Adolescent; Adult; Aged; Cell Line; Deoxyuridine; DNA, Neoplasm; Drug Resistance; Female; Humans; Leukemia; Male; Methotrexate; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tritium | 1986 |
Influence of hypoxia on the metabolism and biliary excretion of trimetrexate by the isolated perfused rat liver.
Topics: Animals; Bile; Half-Life; Hypoxia; In Vitro Techniques; Kinetics; Liver; Male; Perfusion; Quinazolines; Rats; Rats, Inbred Strains; Trimetrexate | 1986 |
Phase I studies with trimetrexate: clinical pharmacology, analytical methodology, and pharmacokinetics.
Topics: Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Evaluation; Hematopoiesis; Humans; Kinetics; Metabolic Clearance Rate; Neoplasms; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1987 |
Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate.
Topics: Animals; Folic Acid Antagonists; Kinetics; Lacticaseibacillus casei; Mice; Mice, Inbred BALB C; Quinazolines; Solubility; Toxoplasma; Toxoplasmosis; Trimetrexate | 1987 |
Determination of plasma trimetrexate levels using gas chromatography-mass spectrometry with selected-ion monitoring.
Topics: Folic Acid Antagonists; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Quinazolines; Trimetrexate | 1986 |
Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent.
Topics: Biological Transport; Folic Acid Antagonists; Kinetics; Methotrexate; NADP; Pneumocystis; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1987 |
Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.
Topics: Animals; Cells, Cultured; Drug Therapy, Combination; Folic Acid Antagonists; Macrophages; Mice; Mice, Inbred BALB C; Pentamidine; Pyrimethamine; Quinazolines; Sulfadiazine; Toxoplasma; Toxoplasmosis, Animal; Trimethoprim; Trimetrexate | 1987 |
Pharmacokinetics of trimetrexate administered by five-day continuous infusion to patients with advanced cancer.
Topics: Adult; Aged; Antineoplastic Agents; Child; Drug Evaluation; Female; Folic Acid Antagonists; Humans; Kidney; Male; Metabolic Clearance Rate; Middle Aged; Quinazolines; Trimetrexate | 1987 |
Phase I and clinical pharmacology study of trimetrexate administered weekly for three weeks.
Topics: Adenocarcinoma; Adult; Aged; Bone Marrow; Chromatography, High Pressure Liquid; Deoxyuridine; Drug Evaluation; Female; Hematopoietic Stem Cells; Humans; Kinetics; Lung Neoplasms; Mathematics; Middle Aged; Quinazolines; Thrombocytopenia; Trimetrexate | 1987 |
Inhibition of lymphocyte nucleic acid metabolism and antibody production by trimetrexate.
Topics: Antibody Formation; Deoxyuridine; DNA; Humans; Interphase; Lymphocytes; Methotrexate; Nucleic Acids; Quinazolines; Thymidine; Trimetrexate | 1987 |
Pediatric phase I trial and pharmacokinetic study of trimetrexate.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Drug Evaluation; Folic Acid Antagonists; Glucuronates; Humans; Infant; Kinetics; Quinazolines; Trimetrexate | 1987 |
Clinical pharmacology of trimetrexate.
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Neoplasm Metastasis; Neoplasms; Quinazolines; Trimetrexate | 1987 |
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Methotrexate; Pyrimethamine; Quinazolines; Rats; Thymidine; Thymidylate Synthase; Trimetrexate | 1987 |
Conformational analysis of antineoplastic antifolates: the crystal structure of trimetrexate and the aminopterine derivative 4-[N-[(2,4-diamino-6-pteridinyl)methyl]amino]benzoic acid.
Topics: Antineoplastic Agents; Crystallization; Folic Acid Antagonists; Methotrexate; Models, Molecular; Quinazolines; Trimetrexate; X-Ray Diffraction | 1987 |
Pneumocystis carinii pneumonitis.
Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Humans; Leucovorin; Pneumonia, Pneumocystis; Quinazolines; Trimetrexate | 1987 |
Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Evaluation; Drug Therapy, Combination; Female; Folic Acid Antagonists; Humans; Leucovorin; Male; Middle Aged; Pneumonia, Pneumocystis; Quinazolines; Sulfadiazine; Trimetrexate | 1987 |
A phase I study of trimetrexate, an analog of methotrexate, administered monthly in the form of nine consecutive daily bolus injections.
Topics: Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Female; Humans; Injections; Male; Middle Aged; Neoplasms; Quinazolines; Trimetrexate | 1987 |
Effects of methotrexate and of the "nonclassical" folate antagonist trimetrexate on human leukemia cells.
Topics: Adenocarcinoma; Colonic Neoplasms; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Leukemia; Methotrexate; Quinazolines; Trimetrexate; Tumor Cells, Cultured | 1987 |
Treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Dapsone; Drug Combinations; Folic Acid Antagonists; Humans; Methylprednisolone; Pentamidine; Pneumonia, Pneumocystis; Quinazolines; Recurrence; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1987 |
Comparative effects on the immune system of methotrexate and trimetrexate.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Antineoplastic Agents; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Immunity; Killer Cells, Natural; Lymphocyte Activation; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Trimetrexate | 1987 |
Trimetrexate: clinical development of a nonclassical antifolate.
Topics: Animals; Biological Availability; Drug Administration Schedule; Drug Evaluation; Folic Acid Antagonists; Humans; Leukemia P388; Mice; Neoplasms; Quinazolines; Structure-Activity Relationship; Trimetrexate | 1987 |
Therapeutic synergy of trimetrexate (CI-898) in combination with doxorubicin, vincristine, cytoxan, 6-thioguanine, cisplatin, or 5-fluorouracil against intraperitoneally implanted P388 leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Synergism; Fluorouracil; Leukemia P388; Leukemia, Experimental; Mice; Quinazolines; Thioguanine; Trimetrexate; Vincristine | 1987 |
Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.
Topics: Acyltransferases; Animals; Drug Synergism; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Liver Neoplasms, Experimental; Phosphoribosylglycinamide Formyltransferase; Pyrimethamine; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Trimetrexate; Tumor Cells, Cultured | 1988 |
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Biological Availability; Chromatography, High Pressure Liquid; Folic Acid Antagonists; Half-Life; Humans; Injections, Intravenous; Middle Aged; Quinazolines; Trimetrexate | 1988 |
Safety and tolerance of trimetrexate: results of a phase II multicenter study in patients with metastatic cancer refractory to conventional therapy or for which no conventional therapy exists.
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Drug Resistance; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Quinazolines; Trimetrexate | 1988 |
Trimetrexate as a single agent in patients with advanced head and neck cancer.
Topics: Adult; Aged; Antineoplastic Agents; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Quinazolines; Trimetrexate | 1988 |
Trimetrexate: a phase 2 study in previously treated patients with metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Female; Humans; Middle Aged; Neoplasm Metastasis; Quinazolines; Time Factors; Trimetrexate | 1988 |
Phase 1 and 2 studies of trimetrexate administered in combination with fluorouracil to patients with metastatic cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Quinazolines; Trimetrexate | 1988 |
Treatment of Pneumocystis carinii pneumonia with trimetrexate in acquired immunodeficiency syndrome (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Agents; Female; Humans; Male; Middle Aged; Pneumonia, Pneumocystis; Quinazolines; Trimetrexate | 1988 |
Trimetrexate: overall clinical results.
Topics: Antineoplastic Agents; Drug Resistance; Humans; Neoplasms; Quinazolines; Trimetrexate | 1988 |
Clinical pharmacology and metabolism of trimetrexate.
Topics: Antineoplastic Agents; Humans; Quinazolines; Trimetrexate | 1988 |
Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate.
Topics: Animals; Folic Acid Antagonists; Mice; Mice, Inbred BALB C; Pneumocystis; Pyrimethamine; Pyrimidines; Quinazolines; Rats; Rats, Inbred Strains; Toxoplasma; Trimetrexate | 1988 |
Suppression of B cell function by methotrexate and trimetrexate. Evidence for inhibition of purine biosynthesis as a major mechanism of action.
Topics: Animals; Antibody Formation; B-Lymphocytes; Cell Differentiation; Female; Folic Acid Antagonists; Immunoglobulins; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Methotrexate; Mice; Purines; Quinazolines; Trimetrexate | 1988 |
[AIDS. Trimetrexate--alternative in Pneumocystis carinii pneumonia].
Topics: Acquired Immunodeficiency Syndrome; Humans; Opportunistic Infections; Pneumonia, Pneumocystis; Quinazolines; Trimetrexate | 1988 |
Phase I clinical and pharmacokinetic study of trimetrexate using a daily x5 schedule.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Bone Marrow; Drug Evaluation; Female; Humans; Male; Middle Aged; Mouth Mucosa; Neoplasms; Quinazolines; Skin; Trimetrexate | 1988 |
Understanding trimetrexate toxicity.
Topics: Antineoplastic Agents; Folic Acid Antagonists; Humans; Quinazolines; Trimetrexate | 1988 |
Correlates of severe or life-threatening toxic effects from trimetrexate.
Topics: Adult; Antineoplastic Agents; Drug Evaluation; Folic Acid Antagonists; Humans; Quinazolines; Serum Albumin; Thrombocytopenia; Trimetrexate | 1988 |
Trimetrexate: predictors of severe or life-threatening toxic effects.
Topics: Antineoplastic Agents; Blood Proteins; Drug Evaluation; Female; Folic Acid Antagonists; Humans; Liver Neoplasms; Male; Protein Binding; Quinazolines; Trimetrexate | 1988 |
Characterization of trimetrexate transport in human lymphoblastoid cells and development of impaired influx as a mechanism of resistance to lipophilic antifolates.
Topics: Antimetabolites, Antineoplastic; Azides; Cell Line; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Humans; Lymphocytes; Pyrimidines; Quinazolines; Sodium Azide; Trimetrexate | 1988 |
Efficacy of trimetrexate, a potent lipid-soluble antifolate, in the treatment of rodent Pneumocystis carinii pneumonia.
Topics: Administration, Oral; Animals; Drug Therapy, Combination; Folic Acid Antagonists; Injections, Subcutaneous; Male; Pneumonia, Pneumocystis; Quinazolines; Rats; Rats, Inbred Strains; Sulfamethoxazole; Trimethoprim; Trimetrexate | 1988 |
Trimetrexate: molecular structures and conformational similarities in two crystal forms.
Topics: Antineoplastic Agents; Crystallization; Models, Molecular; Molecular Conformation; Quinazolines; Trimetrexate | 1988 |
Trimetrexate in advanced carcinoma of the esophagus.
Topics: Carcinoma, Squamous Cell; Drug Evaluation; Esophageal Neoplasms; Humans; Quinazolines; Trimetrexate | 1988 |
Inhibition of metabolism of the 'nonclassical' antifolate, trimetrexate (2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline) by drugs containing an imidazole moiety.
Topics: Animals; Dealkylation; Folic Acid Antagonists; Imidazoles; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Quinazolines; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Trimetrexate | 1985 |
Competitive protein-binding assay for trimetrexate.
Topics: Animals; Male; Mice; Quinazolines; Radioligand Assay; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1985 |
FDA bends rules on experimental AIDS drug.
Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Glucuronates; Health Policy; Humans; Public Health; Quinazolines; Trimetrexate; United States; United States Food and Drug Administration | 1988 |
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; Structure-Activity Relationship; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1983 |
Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines.
Topics: Animals; Antimalarials; Antineoplastic Agents; Bacteria; Drug Resistance; Folic Acid Antagonists; Haplorhini; Leukemia L1210; Leukemia P388; Mice; Plasmodium falciparum; Quinazolines; Trimetrexate | 1983 |
Use of a human tumor cloning system to evaluate analogs of methotrexate and mitoxantrone.
Topics: Anthraquinones; Antineoplastic Agents; Cell Line; Colony-Forming Units Assay; Drug Evaluation, Preclinical; Humans; Methotrexate; Mitoxantrone; Neoplasms; Quinazolines; Trimetrexate; Tumor Stem Cell Assay | 1984 |
Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cells in vitro.
Topics: Animals; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Trimetrexate | 1984 |
Resistance of human tumor cell lines to antifolates.
Topics: B-Lymphocytes; Biological Transport; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Karyotyping; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1984 |
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Ribonucleotides; Thymidine; Trimetrexate | 1984 |
Enzymatic assays for 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline, a promising new "nonclassical" antifolate.
Topics: Animals; Biological Assay; Cattle; Folic Acid Antagonists; Injections, Intravenous; Kinetics; Quinazolines; Trimetrexate | 1981 |
Comparative effects of methotrexate, two nonclassic folic acid antagonists, and cytarabine on hematopoietic precursor cells.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Cytarabine; Dogs; Dose-Response Relationship, Drug; Folic Acid Antagonists; Hematopoietic Stem Cells; Humans; In Vitro Techniques; Methotrexate; Mice; Quinazolines; Species Specificity; Triazines; Trimetrexate | 1982 |
Pharmacology and toxicity of a potent "nonclassical" 2,4-diamino quinazoline folate antagonist, trimetrexate, in normal dogs.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Diarrhea; Dogs; Drug Evaluation, Preclinical; Feces; Folic Acid Antagonists; Half-Life; Injections, Intravenous; Kidney; Liver; Quinazolines; Reference Values; Tetrahydrofolate Dehydrogenase; Tissue Distribution; Trimetrexate | 1982 |
Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines.
Topics: Animals; Antifungal Agents; Candida albicans; Drug Design; Folic Acid Antagonists; Humans; Mice; Pyrimethamine; Pyrimidines; Quinazolines; Recombinant Proteins; Structure-Activity Relationship; Trimethoprim; Trimetrexate | 1995 |
The toxicity of antifolates in Babesia bovis.
Topics: Animals; Babesia bovis; Folic Acid; Folic Acid Antagonists; Pyrimethamine; Pyrimidines; Quinazolines; Trimethoprim; Trimetrexate | 1993 |
Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues.
Topics: Antineoplastic Agents; Base Sequence; Blotting, Southern; DNA, Neoplasm; Drug Resistance; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Methotrexate; Molecular Sequence Data; Oligonucleotide Probes; Polymerase Chain Reaction; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured | 1993 |
Effect of hammerhead ribozyme against human thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitors.
Topics: B-Lymphocytes; Base Sequence; Drug Resistance; Drug Synergism; Enzyme Induction; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Molecular Sequence Data; Nucleic Acid Conformation; Quinazolines; Repetitive Sequences, Nucleic Acid; RNA, Catalytic; RNA, Messenger; Thiophenes; Thymidylate Synthase; Transfection; Trimetrexate | 1995 |
Quinoxaline chemistry. Part 9. Quinoxaline analogues of trimetrexate (TMQ) and 10-propargyl-5,8-dideazafolic acid (CB 3717) and its precursors. Synthesis and evaluation of in vitro anticancer activity.
Topics: Antineoplastic Agents; Folic Acid; Humans; Quinazolines; Quinoxalines; Structure-Activity Relationship; Trimetrexate; Tumor Cells, Cultured | 1998 |
Quinoxaline chemistry. Part 10. Quinoxaline 10-oxa-analogues of trimetrexate (TMQ) and of 5,8-dideazafolic acid. Synthesis and evaluation of in vitro anticancer activity.
Topics: Antineoplastic Agents; Humans; Quinazolines; Quinoxalines; Structure-Activity Relationship; Trimetrexate; Tumor Cells, Cultured | 1998 |
Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Quinazolines; Thiophenes; Treatment Outcome; Trimetrexate | 1999 |
A comparison of the effects of nine folate analogs on early and late murine hematopoietic progenitor cells in vitro.
Topics: Aminopterin; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Hematopoietic Stem Cells; Methotrexate; Mice; Mice, Inbred BALB C; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 2000 |
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Blotting, Northern; Blotting, Southern; Blotting, Western; Carrier Proteins; Cell Division; Cell Membrane; Chlorides; DNA Mutational Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Exons; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Kinetics; Leucovorin; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mutagenesis, Site-Directed; Mutation; Polymorphism, Single-Stranded Conformational; Protein Structure, Secondary; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins; Reduced Folate Carrier Protein; Thymidylate Synthase; Time Factors; Transfection; Trimetrexate; Tumor Cells, Cultured | 2000 |
Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cecal Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Folic Acid; Glutamates; Hematinics; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Ileal Neoplasms; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Pyrimidines; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured | 2003 |
A new nonlinear mixture response surface paradigm for the study of synergism: a three drug example.
Topics: Adenocarcinoma; Algorithms; Antimetabolites; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Humans; Hydroxymethyl and Formyl Transferases; Intestinal Neoplasms; Models, Biological; Nonlinear Dynamics; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 2003 |
p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.
Topics: Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Stability; Fibrosarcoma; Folic Acid Antagonists; Humans; Methotrexate; Neoplastic Stem Cells; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53 | 2004 |
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Blotting, Northern; Carrier Proteins; Cell Line; Cell Line, Tumor; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Ions; Kinetics; Membrane Transport Proteins; Methotrexate; Pemetrexed; Protein Isoforms; Quinazolines; Receptors, Cell Surface; Reduced Folate Carrier Protein; RNA; Thiophenes; Time Factors; Transfection; Trimetrexate | 2004 |
Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Lipids; Molecular Structure; Mutation; Neoplasm Proteins; Paclitaxel; Pyrimethamine; Pyrimidines; Quinazolines; Rhodamines; Transfection; Trimetrexate | 2006 |
Methotrexate analogues display enhanced inhibition of TNF-α production in whole blood from RA patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; Ornithine; Pterins; Quinazolines; T-Lymphocytes; Thiophenes; Trimetrexate; Tumor Necrosis Factor-alpha | 2014 |