Compounds > quinazolines
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quinazolines and transforming growth factor alpha

quinazolines has been researched along with transforming growth factor alpha in 98 studies

Research

Studies (98)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (5.10)18.2507
2000's65 (66.33)29.6817
2010's28 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Coffey, RJ; Der, CJ; Gangarosa, LM; Graves-Deal, R; Oldham, SM; Sizemore, N1
Berthelemy, M; Dangles, V; Féménia, F; Lainé, V; Le Rhun, D; Levy, D; Poupon, MF; Schwartz-Cornil, I1
Cantley, LG; Kjelsberg, CA; Nigam, SK; Sakurai, H; Tsukamoto, T1
Higashimoto, Y; Kanayama, S; Kiyohara, T; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Sugimachi, M; Tsutsui, S; Zushi, S1
Bartlett, JM; Gordge, P; Langdon, SP; Leake, RE; Macleod, KG; Miller, EP; Miller, WR; Rabiasz, G; Rae, AL; Simpson, BJ; Smyth, J1
Cupp, AS; Levine, E; Miyashiro, L; Skinner, MK1
Dorko, K; Esplen, JE; Jo, M; Michalopoulos, GK; Stolz, DB; Strom, SC1
Blaudschun, R; Brenneisen, P; Meewes, C; Scharffetter-Kochanek, K; Wlaschek, M1
Arteaga, CL; Coffey, RJ; Forbes, JT; Lenferink, AE; Shawver, LK; Simpson, JF1
Bergström, JD; Heldin, NE; Westermark, B1
Ciardiello, F1
Chen, F; Ireland, ME; Mrock, LK1
Brychzy, A; de Paulsen, N; Fournier, MC; Gnarra, JR; Klausner, RD; Lee, S; Pause, A1
Egeblad, M; Jäättelä, M; Mortensen, OH; van Kempen, LC1
Burchiel, SW; Burdick, AD; Davis, JW; Hudson, LG; Lauer, FT1
Bianco, AR; Bianco, R; Caputo, R; Ciardiello, F; Cuccato, S; Damiano, V; De Placido, S; Fontanini, G; Tortora, G1
Pouysségur, J; Viñals, F1
Brattain, MG; Ghosh, P; Humphrey, LE; Kreisberg, JI; Sawhney, RS; Zhou, GH1
Atabai, K; Birch, M; Burgel, PR; Lazarus, SC; Nadel, JA; Tam, DC; Ueki, IF1
Adler, KB; Bonner, JC; Booth, BW; Martin, LD; Tournier, F1
Arteaga, CL; Bianco, R; Moulder, SL; Muthuswamy, SK; Simpson, JF; Yakes, FM1
El-Obeid, A; Hesselager, G; Nistér, M; Westermark, B1
Bates, SE; Bishop, PC; Blagosklonny, MV; Fry, DW; Liu, ET; Myers, T; Robey, R1
Bianco, AR; Biroccio, A; Borriello, G; Caputo, R; Ciardiello, F; Del Bufalo, D; Tortora, G; Zupi, G1
Assender, J; Barrow, D; Dewhurst, OL; Dutkowski, CM; Glynne-Jones, E; Goddard, L; Harper, ME; Nicholson, RI; Wakeling, AE1
Fujimura, M; Hidaka, T; Saito, S1
Barrett, KE; McCole, DF; Uribe, JM1
Barrow, D; Gee, JM; Harper, ME; Hutcheson, IR; Jones, HE; Knowlden, JM; Madden, T; Nicholson, RI; Wakeling, AE1
Li, J; Majumdar, AP; Xiao, ZQ1
Attoub, S; Bruyneel, E; Emami, S; Gespach, C; Mareel, M; May, FE; Nguyen, QD; Rodrigue, CM; Rodrigues, S; Thim, L; Westley, BR1
Abbou, CC; Chopin, DK; Daher, A; de Boer, WI; El-Marjou, A; Radvanyi, F; Thiery, JP; van der Kwast, T1
Ashida, M; Bito, T; Budiyanto, A; Ichihashi, M; Kunisada, M; Ueda, M1
Cho, YM; Foley, J; Gocken, TA; Koltz, PF; Konger, RL; Lewis, DA; Richard, V; Rosol, TJ; Spandau, DF1
Ono, M1
Abraham, S; Egan, LJ; Myhre, GM; Toruner, M1
Bowling, GH; Khan, SA; Millena, AC; Reddy, SC1
Brahimi, F; Jean-Claude, BJ; Li, YJ; McNamee, JP; Qiu, Q; Rachid, Z; Tari, AM1
Barnard, GF; Inoue, H; Ishii, H; Ishikawa, K; Mimori, K; Mori, M; Ohta, M; Utsunomiya, T; Yamashita, K; Yoshinaga, K1
Bekele, BN; Doan, D; El-Naggar, AK; Holsinger, FC; Jasser, SA; Kim, S; Mandal, M; McMurphy, AB; Myers, JN; Schiff, BA; Sherman, SI; Yeung, SC; Yigitbasi, OG; Younes, MN; Zhou, G1
Barbu, V; Cacheux, W; Clergue, F; Desbois-Mouthon, C; Housset, C; Poupon, R; Rey, C; Rosmorduc, O; Schiffer, E; Wendum, D1
Kishida, O; Kiyohara, T; Miyazaki, T; Miyazaki, Y; Murayama, Y; Ogasa, M; Shimomura, I; Shinomura, Y; Tsutsui, S; Watabe, K; Yamamoto, T2
Faj, D; Kurbel, S1
Bell, DW; Haber, DA; Louis, DN; Riemenschneider, MJ1
Hill, G; Pellegrin, S; Selby, PJ; Shaw, NJ; Southgate, J; Trejdosiewicz, LK; Varley, C1
Gooding, WE; Grandis, JR; Lui, VW; Siegfried, JM; Thomas, SM; Wentzel, AL1
Civiello, G; Janne, PA; Johnson, BE; Mukohara, T1
Daigo, Y; Hayama, S; Inai, K; Ishikawa, N; Kato, T; Kohno, N; Murakami, H; Nakamura, Y; Nishimura, H; Takano, A; Takeshima, Y; Taniwaki, M; Tsuchiya, E1
Brockstein, BE; Cohen, EE; Dekker, A; Huo, D; Kane, MA; List, MA; Mauer, AM; Mehrotra, B; Pierce, C; Vokes, EE1
Akizawa, T; Hatamura, I; Negi, S; Orita, H; Saji, F; Sakaguchi, T; Shibata, M; Shiizaki, K1
Iwakura, Y; Jourdi, H; Nagano, T; Namba, H; Nawa, H; Takei, N; Xiong, H1
Bolotin, D; Chu, DH; Fuchs, E; Polak, L; Wang, X; Williams, T1
Ancha, HB; Ancha, HR; Harty, RF; Tedesco, DS; Ward, AR1
Matsumoto, K; Murawaki, Y; Nagahara, T; Okano, J1
Abbruzzese, JL; Baker, CH; Cognetti, F; McConkey, DJ; Pino, MS; Shrader, M; Xiong, HQ1
Arteaga, CL; Carpenter, G; Gazdar, AF; Muthuswamy, SK; Narasanna, A; Perez-Torres, M; Wang, SE; Wu, FY; Xiang, B; Yang, S1
Desbois-Mouthon, C; Fartoux, L; Poupon, R; Rosmorduc, O1
Baker, CH; Bekele, N; Fidler, IJ; Herbst, RS; Langley, RR; O'Reilly, MS; Onn, A; Tang, XM; Tsan, RZ; Wu, W1
Alvarez-Hernandez, D; Arcidiacono, MV; Cannata-Andia, J; Dusso, AS; Gonzalez-Suarez, I; Lu, Y; Sato, T; Slatopolsky, E; Tokumoto, M; Tominaga, Y; Yang, J1
Davidson, C; Hardie, WD; Ikegami, M; Korfhagen, TR; Le Cras, TD; Leikauf, GD; Prestridge, A; Whitsett, JA1
Holtkamp, N; Malzer, E; Mautner, VF; Mawrin, C; Mucha, J; Okuducu, AF; Schildhaus, HU; von Deimling, A; Zietsch, J1
Fennell, DA; Johnston, PG; Kelly, DM; Kyula, J; Longley, DB; Stokesberry, S; Van Schaeybroeck, S1
Beales, IL; Ogunwobi, OO1
Blair, E; Clark, JI; Cohen, EE; Dancey, JE; Davis, DW; Dekker, A; Karrison, TG; Kozloff, MF; Liu, W; Nattam, S; Pierce, C; Seiwert, TY; Stenson, K; Vokes, EE; Wong, SJ; Yan, DH1
Aboulafia, AJ; Cummings, JE; Damron, TA; Joyner, DE; Randall, RL; Trang, SH1
Davidson, CR; Hardie, WD; Ikegami, M; Korfhagen, TR; Le Cras, TD; Schmidt, SM; Whitsett, JA1
Kanayama, M; Maekawa, T; Takahashi, S; Takeuchi, S1
Cáceres, M; González, MJ; Guerrero, J; Martínez, J; Smith, PC; Tobar, N1
España, A; López-Picazo, JM; López-Zabalza, MJ; Marquina, M; Pelacho, B; Pretel, M1
Ren, S; Tang, L; Yan, L; Zhang, J; Zhang, L; Zhou, C; Zhou, S1
Alvares, EP; Curi, MA; Gama, P; Osaki, LH1
Bollinger, N; Joslin, EJ; Lauffenburger, DA; Opresko, LK; Shankaran, H; Wiley, HS1
Chen, ZC; Guan, YJ; Li, C; Li, MY; Li, XH; Liang, K; Peng, F; Tang, CE; Xiao, ZQ; Yao, KT; Yi, B; Yi, H; Zhang, PF; Zou, HY1
Bang, YJ; Cha, Y; Ham, HS; Han, SW; Im, SA; Im, YH; Kim, HP; Kim, TY; Lee, KS; Oh, DY; Park, IH; Park, JW; Rhee, J; Ro, J1
Carlomagno, F; Chiappetta, G; Ciardiello, F; Coluzzi, S; De Falco, V; Fagin, JA; Ryan, AJ; Santoro, M; Tamburrino, A; Tortora, G; Troncone, G; Vitagliano, D1
Addison, CL; Bradbury, PA; Ding, K; Goss, GD; Le Maître, A; Seymour, L; Shepherd, FA; Tsao, MS; Zhao, H1
Fenning, CS; Fenton, A; Johnston, PG; Kyula, JN; Longley, DB; Sasazuki, T; Shirasawa, S; Van Schaeybroeck, S1
An, SJ; Chen, ZH; Cheng, H; Dong, S; Wu, YL; Zhang, XC; Zhang, YF1
Partridge, NC; Qin, L; Shimizu, E; Zhang, X; Zhu, J1
Gooding, WE; Grandis, JR; Gubish, CT; Siegfried, JM; Stabile, LP; Xu, H1
Carrasco, M; Castro, C; Estrada, C; López-Toledano, MA; Murillo-Carretero, M; Romero-Grimaldi, C1
Li, Y; Wang, H; Xia, Y; Xu, W; Yan, J1
Del Castillo, G; Fabregat, I; Fernández, M; Herrera, B; Martínez-Palacián, A; Roncero, C; Sánchez, A1
Argiris, A; Ferris, RL; Freilino, ML; Gooding, WE; Grandis, JR; Gross, N; Moskowitz, HS; Thomas, SM1
Hashimoto, M; Koizumi, F; Minakata, K; Moriyama, H; Murakami, A; Nara, T; Nishio, K; Nurwidya, F; Seyama, K; Tajima, K; Takahashi, F; Takahashi, K; Yae, S1
Atlas, MD; Dilley, RJ; Marano, RJ; Mei Teh, B; Redmond, SL; Shen, Y1
Batlle, D; Egido, J; Eguchi, S; Keri, G; Morgado-Pascual, JL; Ortiz, A; Pato, J; Ramos, AM; Rayego-Mateos, S; Ruiz-Ortega, M; Sanz, AB1
Ahuja, A; Chan, AT; Chan, C; Chan, SL; Dattatray, RD; Ho, WM; Hui, EP; King, AD; Lau, W; Ma, BB; Mo, F; Poon, A; To, KF; Wong, SC1
Cao, F; Fan, FT; Kang, XH; Wang, LF; Xu, ZY1
Dong, X; He, C; Jiang, H; Jiang, X; Ma, L; Pan, S; Qiao, H; Sun, X; Tan, G; Wei, Z; Zhai, B; Zhao, D1
Chan, DC; Jensen, RT; Mantey, SA; Moody, TW; Moreno, P1
Abu-Humaidan, AH; Alberius, P; Ananthoju, N; Garred, P; Mohanty, T; Schmidtchen, A; Sonesson, A; Sørensen, OE1
Jiang, Y; Pan, X; Sun, C; Wang, Q; Xiao, W; Yang, Z; Zhang, Y; Zhu, M1
Kimura, M; Moteki, H; Ogihara, M1
Appleton, CT; Beier, F; Mort, JS; Pest, MA; Pitelka, V; Usmani, SE1
Aschner, M; Johnson, J; Karki, P; Lee, E; Son, DS1
Campion, CM; Cole, JA; Leon Carrion, S; Mamidanna, G; Sutter, CH; Sutter, TR1
Böhning, E; Calvisi, DF; Cigliano, A; Dombrowski, F; Evert, M; Günther, J; Merz, J; Peters, K; Pilo, MG; Ribback, S; Sailer, V; Steinmüller, F; Utpatel, K1

Reviews

2 review(s) available for quinazolines and transforming growth factor alpha

ArticleYear
Epidermal growth factor receptor tyrosine kinase inhibitors as anticancer agents.
    Drugs, 2000, Volume: 60 Suppl 1

    Topics: Administration, Oral; Antibodies, Monoclonal; Antineoplastic Agents; Disease Progression; ErbB Receptors; Gefitinib; Humans; Ligands; Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Transforming Growth Factor alpha

2000
[Anti-EGFR therapy: towards a "à la carte" targeting of hepatocellular carcinoma].
    Gastroenterologie clinique et biologique, 2006, Volume: 30, Issue:10

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cetuximab; Clinical Trials, Phase II as Topic; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Ligands; Liver Neoplasms; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Protein Kinase Inhibitors; Quinazolines; Rats; Signal Transduction; Transforming Growth Factor alpha

2006

Trials

5 trial(s) available for quinazolines and transforming growth factor alpha

ArticleYear
Phase II trial of gefitinib 250 mg daily in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Dec-01, Volume: 11, Issue:23

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Squamous Cell; Disease-Free Survival; Drug Administration Schedule; Female; Gefitinib; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Quality of Life; Quinazolines; Salvage Therapy; Survival Rate; Transforming Growth Factor alpha; Vascular Endothelial Growth Factor A

2005
Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study.
    The Lancet. Oncology, 2009, Volume: 10, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carcinoma, Squamous Cell; ErbB Receptors; Erlotinib Hydrochloride; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Multivariate Analysis; Quinazolines; Regression Analysis; Transforming Growth Factor alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2009
Clinical efficacy of erlotinib in patients previously treated for advanced non-small cell lung cancer.
    Respirology (Carlton, Vic.), 2009, Volume: 14, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Disease Progression; Erlotinib Hydrochloride; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Predictive Value of Tests; Protein Kinase Inhibitors; Quinazolines; Retrospective Studies; Survival Rate; Transforming Growth Factor alpha; Treatment Outcome; Vascular Endothelial Growth Factor A

2009
Serum biomarker modulation following molecular targeting of epidermal growth factor and cyclooxygenase pathways: a pilot randomized trial in head and neck cancer.
    Oral oncology, 2012, Volume: 48, Issue:11

    Topics: Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Erlotinib Hydrochloride; Female; Head and Neck Neoplasms; Hepatocyte Growth Factor; Humans; Interleukin-6; Male; Middle Aged; Neoadjuvant Therapy; Pilot Projects; Placebos; Prospective Studies; Protein Kinase Inhibitors; Quinazolines; Sulindac; Transforming Growth Factor alpha

2012
Intermittent versus continuous erlotinib with concomitant modified "XELOX" (q3W) in first-line treatment of metastatic colorectal cancer: correlation with serum amphiregulin and transforming growth factor alpha.
    Cancer, 2013, Dec-01, Volume: 119, Issue:23

    Topics: Adult; Aged; Amphiregulin; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; EGF Family of Proteins; Erlotinib Hydrochloride; Female; Fluorouracil; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Mutation; Neoplasm Metastasis; Oxaloacetates; Patient Compliance; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; Transforming Growth Factor alpha

2013

Other Studies

91 other study(ies) available for quinazolines and transforming growth factor alpha

ArticleYear
A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells.
    The Journal of biological chemistry, 1997, Jul-25, Volume: 272, Issue:30

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Enzyme Inhibitors; ErbB Receptors; Intestinal Mucosa; Ligands; Oncogene Protein pp60(v-src); Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Rats; RNA, Messenger; Transforming Growth Factor alpha; Up-Regulation

1997
Two- and three-dimensional cell structures govern epidermal growth factor survival function in human bladder carcinoma cell lines.
    Cancer research, 1997, Aug-15, Volume: 57, Issue:16

    Topics: Apoptosis; Culture Media, Serum-Free; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Isoflavones; Neoplasm Proteins; Nitriles; Protein-Tyrosine Kinases; Quinazolines; Spheroids, Cellular; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation; Urinary Bladder Neoplasms

1997
EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 2

    Topics: Animals; Aprotinin; Cell Line; Coculture Techniques; Collagen; Cysteine Proteinase Inhibitors; Embryonic Induction; Enzyme Inhibitors; Epithelium; ErbB Receptors; Hepatocyte Growth Factor; Kidney; Kidney Medulla; Kidney Tubules, Collecting; Leucine; Ligands; Mice; Mice, Knockout; Morphogenesis; Nitriles; Phenanthrolines; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Quinazolines; Receptor Protein-Tyrosine Kinases; Transforming Growth Factor alpha; Tyrphostins

1997
Role of heparin-binding EGF-related peptides in proliferation and apoptosis of activated ras-stimulated intestinal epithelial cells.
    International journal of cancer, 1997, Dec-10, Volume: 73, Issue:6

    Topics: Amphiregulin; Animals; Apoptosis; Autocrine Communication; Betacellulin; Cell Division; Cells, Cultured; Chlorates; Culture Media, Conditioned; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Nitriles; Phosphorylation; Polysaccharide-Lyases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; ras Proteins; Rats; RNA; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation

1997
Inhibition of transforming growth factor alpha (TGF-alpha)-mediated growth effects in ovarian cancer cell lines by a tyrosine kinase inhibitor ZM 252868.
    British journal of cancer, 1999, Volume: 79, Issue:7-8

    Topics: Cell Division; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured

1999
Role of transforming growth factor-alpha and the epidermal growth factor receptor in embryonic rat testis development.
    Biology of reproduction, 2000, Volume: 62, Issue:3

    Topics: Animals; Animals, Newborn; Antibody Specificity; Cell Division; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation, Developmental; Male; Mice; Mice, Knockout; Quinazolines; Rats; Rats, Sprague-Dawley; Testis; Transforming Growth Factor alpha; Tyrphostins

2000
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.
    The Journal of biological chemistry, 2000, Mar-24, Volume: 275, Issue:12

    Topics: Animals; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-met; Quinazolines; Rats; Receptor Cross-Talk; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2000
The first peak of the UVB irradiation-dependent biphasic induction of vascular endothelial growth factor (VEGF) is due to phosphorylation of the epidermal growth factor receptor and independent of autocrine transforming growth factor alpha.
    FEBS letters, 2000, Jun-02, Volume: 474, Issue:2-3

    Topics: Antibodies; Autocrine Communication; Cell Line; Endothelial Growth Factors; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epidermal Cells; Epidermis; ErbB Receptors; Humans; Lymphokines; Models, Biological; Phosphorylation; Protein Isoforms; Quinazolines; RNA, Messenger; Time Factors; Transforming Growth Factor alpha; Ultraviolet Rays; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Aug-15, Volume: 97, Issue:17

    Topics: Animals; Butadienes; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Division; Cell Transformation, Neoplastic; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Dimerization; DNA; Down-Regulation; ErbB Receptors; Female; Humans; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Nitriles; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins

2000
Epidermal growth factor receptor signaling activates met in human anaplastic thyroid carcinoma cells.
    Experimental cell research, 2000, Aug-25, Volume: 259, Issue:1

    Topics: Antineoplastic Agents; Butadienes; Carcinoma; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-met; Quinazolines; RNA, Messenger; Suramin; Thyroid Neoplasms; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2000
A role for endogenous TGFalpha and associated signaling pathways in the differentiation of lens fiber cells.
    Journal of cellular physiology, 2001, Volume: 186, Issue:2

    Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Chickens; Cyclic AMP; Enzyme Inhibitors; ErbB Receptors; Eye Proteins; Intermediate Filament Proteins; Isoproterenol; Lens, Crystalline; Mitogen-Activated Protein Kinase 1; Phosphorylation; Quinazolines; Receptor Cross-Talk; Signal Transduction; Transforming Growth Factor alpha

2001
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Feb-13, Volume: 98, Issue:4

    Topics: Adenocarcinoma, Clear Cell; Cell Division; Cell Hypoxia; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Genes, Tumor Suppressor; Growth Substances; Humans; Insulin; Kidney Neoplasms; Ligases; Oligodeoxyribonucleotides, Antisense; Proteins; Quinazolines; Selenium; Transferrin; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins; Ubiquitin-Protein Ligases; von Hippel-Lindau Disease; Von Hippel-Lindau Tumor Suppressor Protein

2001
BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.
    Biochemical and biophysical research communications, 2001, Feb-16, Volume: 281, Issue:1

    Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoblotting; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuregulin-1; Organic Chemicals; Phosphorylation; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Recombinant Proteins; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2001
Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production.
    Cancer research, 2001, Apr-15, Volume: 61, Issue:8

    Topics: Apoptosis; Benzothiazoles; Breast; Cell Count; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Polychlorinated Dibenzodioxins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Messenger; Transforming Growth Factor alpha; Tyrphostins

2001
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Synergism; Endothelial Growth Factors; ErbB Receptors; Female; Fibroblast Growth Factor 2; Gefitinib; Growth Substances; Humans; Immunohistochemistry; Inhibitory Concentration 50; Lymphokines; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Quinazolines; Transforming Growth Factor alpha; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays

2001
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.
    Molecular and cellular biology, 2001, Volume: 21, Issue:21

    Topics: Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Chromones; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Wortmannin

2001
Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands.
    The Journal of biological chemistry, 2002, Jan-04, Volume: 277, Issue:1

    Topics: Antigens, CD; Cell Adhesion; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix Proteins; Humans; Integrin alpha2; Ligands; Quinazolines; RNA, Messenger; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2002
Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Nov-15, Volume: 167, Issue:10

    Topics: Adult; Asthma; Cells, Cultured; Culture Media, Conditioned; Enzyme Inhibitors; Eosinophils; ErbB Receptors; Humans; Hypersensitivity; Middle Aged; Mucin 5AC; Mucins; Phosphorylation; Pulmonary Eosinophilia; Quinazolines; Respiratory Mucosa; RNA, Messenger; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation

2001
Interleukin-13 induces proliferation of human airway epithelial cells in vitro via a mechanism mediated by transforming growth factor-alpha.
    American journal of respiratory cell and molecular biology, 2001, Volume: 25, Issue:6

    Topics: Bronchi; Cell Division; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Humans; Interleukin-13; Models, Biological; Quinazolines; Signal Transduction; Transforming Growth Factor alpha; Tyrphostins

2001
Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo.
    Cancer research, 2001, Dec-15, Volume: 61, Issue:24

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Catalytic Domain; Cell Cycle; Cell Division; Cell Survival; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; Gefitinib; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Proto-Oncogene Mas; Quinazolines; Receptor, ErbB-2; Signal Transduction; Substrate Specificity; Transforming Growth Factor alpha; Trastuzumab; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2001
TGF-alpha-driven tumor growth is inhibited by an EGF receptor tyrosine kinase inhibitor.
    Biochemical and biophysical research communications, 2002, Jan-11, Volume: 290, Issue:1

    Topics: Animals; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Division; DNA, Complementary; Enzyme Inhibitors; ErbB Receptors; Glioma; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; RNA; RNA, Messenger; Tetracycline; Time Factors; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine; Tyrphostins

2002
Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family.
    Oncogene, 2002, Jan-03, Volume: 21, Issue:1

    Topics: Cell Cycle; Cell Line, Transformed; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Resistance, Neoplasm; Enzyme Induction; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Neoplasm Proteins; Neoplasms; Pyrimidines; Quinazolines; Receptor, ErbB-2; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyrphostins

2002
ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells.
    International journal of cancer, 2002, Mar-20, Volume: 98, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Bridged-Ring Compounds; Cell Division; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; Fibroblast Growth Factor 2; Gefitinib; Humans; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Taxoids; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured

2002
Multiple responses to EGF receptor activation and their abrogation by a specific EGF receptor tyrosine kinase inhibitor.
    The Prostate, 2002, Jun-01, Volume: 52, Issue:1

    Topics: Adenocarcinoma; Apoptosis; Blotting, Northern; Blotting, Western; Cell Count; Cell Cycle; Cell Division; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Immunohistochemistry; Male; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Phosphorylation; Prostatic Neoplasms; Quinazolines; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured

2002
Selective inhibition of the epidermal growth factor receptor by ZD1839 decreases the growth and invasion of ovarian clear cell adenocarcinoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:7

    Topics: Adenocarcinoma, Clear Cell; Animals; Antineoplastic Agents; Cell Division; Cytokines; Endothelial Growth Factors; ErbB Receptors; Female; Gefitinib; Growth Substances; Humans; Immunoenzyme Techniques; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mice, SCID; Ovarian Neoplasms; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Transforming Growth Factor alpha; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Interferon-gamma activates EGF receptor and increases TGF-alpha in T84 cells: implications for chloride secretion.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:4

    Topics: Antibodies; Blotting, Western; Carbachol; Cell Line; Cell Membrane; Chlorides; Colon; Enzyme Inhibitors; ErbB Receptors; Humans; Immunosorbent Techniques; Interferon-gamma; Intestinal Mucosa; Kinetics; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; src-Family Kinases; Transforming Growth Factor alpha; Tyrphostins

2002
Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells.
    Endocrinology, 2003, Volume: 144, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cell Division; Dimerization; Drug Resistance, Neoplasm; ErbB Receptors; Flavonoids; Gefitinib; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Receptor, ErbB-2; RNA, Messenger; Tamoxifen; Transforming Growth Factor alpha; Trastuzumab; Tumor Cells, Cultured

2003
Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:2

    Topics: Aging; Animals; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Gastric Mucosa; Male; Mitogen-Activated Protein Kinase Kinases; Pyrimidines; Quinazolines; Rats; Rats, Inbred F344; Signal Transduction; src-Family Kinases; Transcription Factor AP-1; Transforming Growth Factor alpha

2003
Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells.
    Oncogene, 2003, Jul-17, Volume: 22, Issue:29

    Topics: Amphiregulin; Animals; Cells, Cultured; Colonic Neoplasms; Dogs; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Genes, src; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Kidney; Mucins; Muscle Proteins; Mutation; Neoplasm Invasiveness; Neuropeptides; Peptides; Phosphatidylinositol 3-Kinases; Proteins; Quinazolines; Receptors, Thromboxane; Signal Transduction; Transforming Growth Factor alpha; Trefoil Factor-1; Trefoil Factor-2; Trefoil Factor-3; Tumor Suppressor Proteins

2003
Epidermal growth factor receptor regulates normal urothelial regeneration.
    Laboratory investigation; a journal of technical methods and pathology, 2003, Volume: 83, Issue:9

    Topics: Amphiregulin; Antibodies, Blocking; Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Movement; Cells, Cultured; DNA Primers; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Quinazolines; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transforming Growth Factor alpha; Tyrphostins; Urothelium; Wound Healing

2003
Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells.
    The Journal of investigative dermatology, 2003, Volume: 121, Issue:5

    Topics: Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphoproteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Quinazolines; Repressor Proteins; RNA, Messenger; Skin Neoplasms; Telomerase; Transforming Growth Factor alpha; Tyrphostins

2003
Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes.
    The Journal of endocrinology, 2004, Volume: 181, Issue:1

    Topics: Adult; Amphiregulin; Antibodies, Monoclonal; Bacterial Proteins; Cell Division; Cells, Cultured; Dactinomycin; EGF Family of Proteins; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression Regulation; Genes, erbB-1; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Infant, Newborn; Intercellular Signaling Peptides and Proteins; Keratinocytes; Parathyroid Hormone-Related Protein; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha

2004
[Screening of antiangiogenic compound].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cyclooxygenase 2; Drug Screening Assays, Antitumor; Gefitinib; Humans; Interleukin-1; Isoenzymes; Lung Neoplasms; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; Quinazolines; Transforming Growth Factor alpha

2004
Metalloprotease disintegrin-mediated ectodomain shedding of EGFR ligands promotes intestinal epithelial restitution.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:6

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Autocrine Communication; Blotting, Western; Cell Line; Culture Media, Conditioned; Epithelium; ErbB Receptors; Immunoprecipitation; Indicators and Reagents; Intestinal Mucosa; Ligands; Metalloendopeptidases; Metalloproteases; Neutralization Tests; Paracrine Communication; Protease Inhibitors; Quinazolines; Rats; Transforming Growth Factor alpha; Tyrphostins

2004
Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha.
    Molecular and cellular endocrinology, 2004, Sep-30, Volume: 224, Issue:1-2

    Topics: Androgens; Animals; Autocrine Communication; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gene Expression Regulation; Isoquinolines; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinases; Phosphoproteins; Quinazolines; Rats; RNA, Messenger; Steroids; Sulfonamides; Transforming Growth Factor alpha; Tyrphostins

2004
Multiple mechanisms of action of ZR2002 in human breast cancer cells: a novel combi-molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA.
    International journal of cancer, 2004, Nov-10, Volume: 112, Issue:3

    Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Molecular Structure; Oncogene Proteins v-erbB; Phosphorylation; Platelet-Derived Growth Factor; Quinazolines; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured

2004
Coexpression of matrix metalloproteinase-7 (MMP-7) and epidermal growth factor (EGF) receptor in colorectal cancer: an EGF receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-15, Volume: 10, Issue:24

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Cell Nucleus; Colorectal Neoplasms; Cytoplasm; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Immunoenzyme Techniques; Male; Matrix Metalloproteinase 7; Middle Aged; Phosphorylation; Protein Transport; Quinazolines; Smad4 Protein; Trans-Activators; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured

2004
Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-15, Volume: 10, Issue:24

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Carcinoma, Papillary; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Mice; Mice, Nude; Paclitaxel; Phosphorylation; Quinazolines; Thyroid Neoplasms; Transforming Growth Factor alpha; Tumor Cells, Cultured

2004
Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis.
    Hepatology (Baltimore, Md.), 2005, Volume: 41, Issue:2

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; ErbB Receptors; Gefitinib; Liver Cirrhosis; Liver Neoplasms; Male; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Transforming Growth Factor alpha

2005
Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.
    Cancer chemotherapy and pharmacology, 2005, Volume: 55, Issue:6

    Topics: Amphiregulin; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Drug Screening Assays, Antitumor; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-8; Irinotecan; Phosphorylation; Quinazolines; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms; Transforming Growth Factor alpha; Tyrosine

2005
Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.
    Cancer chemotherapy and pharmacology, 2005, Volume: 55, Issue:4

    Topics: Adenocarcinoma; Amphiregulin; Antineoplastic Agents; Camptothecin; EGF Family of Proteins; ErbB Receptors; Gefitinib; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-8; Irinotecan; Metalloproteases; Phosphorylation; Quinazolines; Reactive Oxygen Species; Stomach Neoplasms; Transforming Growth Factor alpha; Tumor Cells, Cultured

2005
Association of skin rash and tumor response to HER1/EGFR inhibition: does HER1 stimulated tumor growth depend on circulatory instead of paracrine ligands?
    Medical hypotheses, 2005, Volume: 64, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Autocrine Communication; Cetuximab; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Exanthema; Humans; Ligands; Models, Biological; Neoplasm Proteins; Neoplasms; Paracrine Communication; Quinazolines; Skin; Transforming Growth Factor alpha; Treatment Outcome

2005
Pulmonary adenocarcinomas with mutant epidermal growth factor receptors.
    The New England journal of medicine, 2005, Apr-21, Volume: 352, Issue:16

    Topics: Adenocarcinoma; Antineoplastic Agents; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Ligands; Lung Neoplasms; Mutation, Missense; Quinazolines; Sequence Deletion; Stromal Cells; Transforming Growth Factor alpha

2005
Autocrine regulation of human urothelial cell proliferation and migration during regenerative responses in vitro.
    Experimental cell research, 2005, May-15, Volume: 306, Issue:1

    Topics: Amphiregulin; Antibodies; Autocrine Communication; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Gene Expression; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Quinazolines; Regeneration; Transforming Growth Factor alpha; Urothelium; Wound Healing

2005
Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells.
    Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:4

    Topics: Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Gefitinib; Humans; Immunoblotting; Immunoprecipitation; Ligands; Lung Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Quinazolines; Receptors, Bombesin; Signal Transduction; Transforming Growth Factor alpha

2005
Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma.
    Oncology, 2005, Volume: 68, Issue:4-6

    Topics: Antibiotics, Antineoplastic; Butadienes; Cell Cycle; Chromones; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Mesothelioma; Mitogen-Activated Protein Kinase 3; Morpholines; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pleural Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; Sirolimus; Transforming Growth Factor alpha; Tumor Cells, Cultured

2005
Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers.
    Cancer research, 2005, Oct-15, Volume: 65, Issue:20

    Topics: Adult; Aged; Aged, 80 and over; Amphiregulin; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Drug Resistance, Neoplasm; EGF Family of Proteins; Enzyme-Linked Immunosorbent Assay; Female; Gefitinib; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Male; Middle Aged; Quinazolines; Transforming Growth Factor alpha

2005
[Enhanced expression of EGFR, TGF-alpha, EGF in hyperplastic parathyroid glands in established stage of renal failure in rats].
    Clinical calcium, 2005, Volume: 15 Suppl 1

    Topics: Animals; Cell Proliferation; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Hyperplasia; Intracellular Signaling Peptides and Proteins; Male; Parathyroid Glands; Parathyroid Hormone; Phosphorus, Dietary; Quinazolines; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Time Factors; Transforming Growth Factor alpha

2005
Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons.
    Molecular and cellular neurosciences, 2006, Volume: 31, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Electrophysiology; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; gamma-Aminobutyric Acid; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ligands; Neurons; Protein Subunits; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Transforming Growth Factor alpha

2006
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.
    The Journal of cell biology, 2006, Jan-30, Volume: 172, Issue:3

    Topics: Animals; Animals, Newborn; Calcium; Caspase 3; Caspases; Cell Proliferation; Chromatin Immunoprecipitation; Chromones; Dermis; DNA; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression; Gene Expression Regulation; Hair Diseases; Integrases; Keratinocytes; Keratins; Ki-67 Antigen; MAP Kinase Signaling System; Mice; Mice, Transgenic; Morpholines; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Skin; Skin Abnormalities; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transforming Growth Factor alpha; Tyrphostins

2006
Inhibition of epidermal growth factor receptor activation enhances in vivo histamine-stimulated gastric acid secretion in the rat.
    Digestive diseases and sciences, 2006, Volume: 51, Issue:2

    Topics: Animals; ErbB Receptors; Gastric Acid; Histamine; Histamine H2 Antagonists; Male; Phosphorylation; Quinazolines; Ranitidine; Rats; Rats, Sprague-Dawley; Transforming Growth Factor alpha; Tyrphostins

2006
Gefitinib and the modulation of the signaling pathways downstream of epidermal growth factor receptor in human liver cancer cells.
    Journal of gastroenterology, 2006, Volume: 41, Issue:2

    Topics: ErbB Receptors; Gefitinib; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured

2006
Transforming growth factor alpha expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines.
    Cancer research, 2006, Apr-01, Volume: 66, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Growth Processes; Cell Line, Tumor; Drug Screening Assays, Antitumor; ErbB Receptors; Gefitinib; Humans; Male; Mice; Mice, Nude; Pancreatic Neoplasms; Phosphorylation; Quinazolines; Signal Transduction; Transforming Growth Factor alpha; Xenograft Model Antitumor Assays

2006
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.
    Cancer cell, 2006, Volume: 10, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Mice; Mice, Nude; Models, Biological; Morpholines; Mutation; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; RNA, Small Interfering; Transforming Growth Factor alpha; Trastuzumab; Xenograft Model Antitumor Assays

2006
Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:10

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Blotting, Western; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Dosage; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Phosphorylation; Purines; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor alpha; Xenograft Model Antitumor Assays

2007
EGFR activation increases parathyroid hyperplasia and calcitriol resistance in kidney disease.
    Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:2

    Topics: Animals; Calcitriol; Carcinoma, Squamous Cell; CCAAT-Enhancer-Binding Protein-beta; Cell Line, Tumor; Disease Models, Animal; Drug Resistance; ErbB Receptors; Erlotinib Hydrochloride; Female; Genes, Reporter; Humans; Hyperparathyroidism, Secondary; Hyperplasia; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Calcitriol; Renal Insufficiency, Chronic; Transforming Growth Factor alpha

2008
EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.
    American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 294, Issue:6

    Topics: Animals; Bronchoalveolar Lavage Fluid; Doxycycline; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Gene Expression; Humans; Mice; Pulmonary Fibrosis; Quinazolines; RNA, Messenger; Transforming Growth Factor alpha

2008
EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy.
    Neuro-oncology, 2008, Volume: 10, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Drug Delivery Systems; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gene Dosage; Genes, p16; Genes, p53; Humans; Immunohistochemistry; Nerve Sheath Neoplasms; Polymorphism, Single-Stranded Conformational; PTEN Phosphohydrolase; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor alpha; Trastuzumab

2008
Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL.
    Cancer research, 2008, Oct-15, Volume: 68, Issue:20

    Topics: ADAM Proteins; ADAM17 Protein; Apoptosis; Colorectal Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; HCT116 Cells; HT29 Cells; Humans; Metalloproteases; Quinazolines; Receptor, ErbB-2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Recombinant Proteins; src-Family Kinases; TNF-Related Apoptosis-Inducing Ligand; Transforming Growth Factor alpha

2008
Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor.
    British journal of biomedical science, 2008, Volume: 65, Issue:3

    Topics: Adenocarcinoma; Amphiregulin; Autoantibodies; Cell Line, Tumor; Cell Proliferation; EGF Family of Proteins; ErbB Receptors; Esophageal Neoplasms; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Leptin; Matrix Metalloproteinases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Transforming Growth Factor alpha; Tyrphostins

2008
Desmoid cell motility is induced in vitro by rhEGF.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2009, Volume: 27, Issue:9

    Topics: Benzamides; Cell Division; Cell Line, Tumor; Cell Movement; Culture Media, Serum-Free; Dioxoles; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibromatosis, Aggressive; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Integrin beta1; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Quinazolines; Receptors, Transforming Growth Factor beta; Recombinant Proteins; RNA, Messenger; RNA, Small Interfering; Soft Tissue Neoplasms; STAT3 Transcription Factor; Transforming Growth Factor alpha; Tyrphostins

2009
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.
    American journal of respiratory cell and molecular biology, 2009, Volume: 41, Issue:5

    Topics: Animals; Carrier Proteins; Collagen; Disease Models, Animal; Disease Progression; Doxycycline; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation; Humans; Lung; Mice; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proliferating Cell Nuclear Antigen; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pulmonary Fibrosis; Quinazolines; Respiratory Mechanics; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Transforming Growth Factor alpha; Uteroglobin

2009
Estradiol, progesterone, and transforming growth factor alpha regulate insulin-like growth factor binding protein-3 (IGFBP3) expression in mouse endometrial cells.
    Zoological science, 2009, Volume: 26, Issue:2

    Topics: Animals; Blotting, Western; DNA; Endometrium; Enzyme Inhibitors; Epithelial Cells; Estradiol; Female; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Mice; Mice, Inbred ICR; Progesterone; Quinazolines; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells; Transforming Growth Factor alpha; Tyrphostins

2009
Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.
    Journal of periodontal research, 2009, Volume: 44, Issue:1

    Topics: Cells, Cultured; Collagen Type I; Culture Media; Enzyme Inhibitors; Enzyme Precursors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gelatinases; Gingiva; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Matrix Metalloproteinase 14; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptors, Cell Surface; Signal Transduction; Transcriptional Activation; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Tyrphostins

2009
An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris.
    Experimental dermatology, 2009, Volume: 18, Issue:9

    Topics: Acantholysis; Animals; Apoptosis; Betacellulin; Carrier Proteins; Disease Models, Animal; Enzyme Activation; Epidermal Growth Factor; Epidermis; ErbB Receptors; Erlotinib Hydrochloride; Humans; Immunoglobulin G; Intercellular Signaling Peptides and Proteins; Intradermal Tests; Isoenzymes; Mice; Mice, Inbred C57BL; Pemphigus; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Quinazolines; Sirolimus; src-Family Kinases; TOR Serine-Threonine Kinases; Transforming Growth Factor alpha

2009
Early weaning accelerates the differentiation of mucous neck cells in rat gastric mucosa: possible role of TGFalpha/EGFR.
    Differentiation; research in biological diversity, 2010, Volume: 79, Issue:1

    Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; ErbB Receptors; Female; Gastric Mucosa; Gene Expression Regulation, Developmental; Immunoenzyme Techniques; Mucin-6; Quinazolines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor alpha; Tyrphostins; Weaning

2010
Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.
    Molecular bioSystems, 2010, Volume: 6, Issue:7

    Topics: Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gefitinib; Gene Regulatory Networks; Hepatocyte Growth Factor; Humans; Imidazoles; Ligands; Lysophospholipids; Mammary Glands, Human; Phosphorylation; Pyridines; Quinazolines; Signal Transduction; Transcriptional Activation; Transforming Growth Factor alpha

2010
Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics.
    Journal of proteome research, 2010, Dec-03, Volume: 9, Issue:12

    Topics: Amyloid beta-Protein Precursor; Androstadienes; Antibodies, Monoclonal; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cystatin C; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; ErbB Receptors; Humans; Immunohistochemistry; Nasopharyngeal Neoplasms; Proteomics; Quinazolines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transforming Growth Factor alpha; Wortmannin

2010
High serum TGF-α predicts poor response to lapatinib and capecitabine in HER2-positive breast cancer.
    Breast cancer research and treatment, 2011, Volume: 125, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Capecitabine; Cell Line, Tumor; Cell Proliferation; Chi-Square Distribution; Deoxycytidine; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Lapatinib; Logistic Models; Middle Aged; Quinazolines; Receptor, ErbB-2; Republic of Korea; Risk Assessment; Risk Factors; Time Factors; Transforming Growth Factor alpha; Treatment Outcome; Up-Regulation

2011
The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells.
    Endocrine-related cancer, 2011, Volume: 18, Issue:1

    Topics: Carcinoma, Medullary; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Humans; Mutation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Quinazolines; Signal Transduction; Thyroid Neoplasms; Transforming Growth Factor alpha; Vascular Endothelial Growth Factor Receptor-2

2011
Plasma transforming growth factor alpha and amphiregulin protein levels in NCIC Clinical Trials Group BR.21.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-20, Volume: 28, Issue:36

    Topics: Amphiregulin; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; EGF Family of Proteins; Erlotinib Hydrochloride; Female; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Male; Middle Aged; Prognosis; Quinazolines; Retrospective Studies; Transforming Growth Factor alpha

2010
Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17.
    Cancer research, 2011, Feb-01, Volume: 71, Issue:3

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Line, Tumor; Cetuximab; Colorectal Neoplasms; Gefitinib; Genes, ras; HCT116 Cells; HT29 Cells; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mice, Inbred BALB C; Mice, SCID; Point Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; Transforming Growth Factor alpha

2011
Molecular mechanism of the schedule-dependent synergistic interaction in EGFR-mutant non-small cell lung cancer cell lines treated with paclitaxel and gefitinib.
    Journal of hematology & oncology, 2011, Jan-21, Volume: 4

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Paclitaxel; Quinazolines; Signal Transduction; Transforming Growth Factor alpha

2011
EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:7

    Topics: 3T3 Cells; Alkaline Phosphatase; Amphiregulin; Animals; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Genetic Markers; Glycoproteins; Heparin-binding EGF-like Growth Factor; Histone Deacetylase 6; Histone Deacetylases; Humans; Integrin-Binding Sialoprotein; Intercellular Signaling Peptides and Proteins; Mice; Neuregulin-1; Osteoblasts; Osteocalcin; Osteogenesis; Quinazolines; Signal Transduction; Sp7 Transcription Factor; Transcription Factors; Transcription, Genetic; Transforming Growth Factor alpha

2011
Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Jul-01, Volume: 17, Issue:13

    Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gefitinib; Head and Neck Neoplasms; Hepatocyte Growth Factor; Humans; Mice; Mice, SCID; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasms, Squamous Cell; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Quinazolines; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Transforming Growth Factor alpha; Wound Healing; Xenograft Model Antitumor Assays

2011
ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells.
    Stem cells (Dayton, Ohio), 2011, Volume: 29, Issue:10

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Astrocytes; Brain Injuries; Cell Differentiation; Cell Proliferation; Dipeptides; Enzyme Activation; ErbB Receptors; Female; Immunohistochemistry; Intermediate Filament Proteins; Male; Mice; Nerve Tissue Proteins; Nestin; Neural Stem Cells; Neurogenesis; Neurons; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transfection; Transforming Growth Factor alpha; Tyrphostins

2011
Lentivirus-mediated ADAM17 RNA interference inhibited interleukin-8 expression via EGFR signaling in lung epithelial cells.
    Inflammation, 2012, Volume: 35, Issue:3

    Topics: ADAM Proteins; ADAM17 Protein; Antibodies, Neutralizing; Cell Line; Epithelial Cells; ErbB Receptors; Gene Transfer Techniques; Genetic Vectors; Humans; Inflammation; Interleukin-8; Lentivirus; Lipopolysaccharides; Lung; Phosphorylation; Quinazolines; Respiratory Mucosa; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor alpha; Tyrphostins

2012
EGFR is dispensable for c-Met-mediated proliferation and survival activities in mouse adult liver oval cells.
    Cellular signalling, 2012, Volume: 24, Issue:2

    Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Deletion; Gene Expression; Heparin-binding EGF-like Growth Factor; Hepatocytes; Intercellular Signaling Peptides and Proteins; Liver; Mice; Mice, Knockout; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Quinazolines; Signal Transduction; Stem Cells; Transforming Growth Factor alpha; Tyrphostins

2012
Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors.
    Cancer science, 2012, Volume: 103, Issue:11

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; MAP Kinase Signaling System; Mutation; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Transforming Growth Factor alpha; Up-Regulation

2012
TGF-α/HA complex promotes tympanic membrane keratinocyte migration and proliferation via ErbB1 receptor.
    Experimental cell research, 2013, Apr-01, Volume: 319, Issue:6

    Topics: Cadherins; Cell Adhesion; Cell Migration Assays; Cell Movement; Cell Proliferation; Cells, Cultured; Epithelial Cells; ErbB Receptors; Humans; Hyaluronan Receptors; Hyaluronic Acid; Interleukins; Keratinocytes; Phenotype; Quinazolines; Transforming Growth Factor alpha; Tympanic Membrane; Tyrphostins; Vitronectin

2013
TWEAK transactivation of the epidermal growth factor receptor mediates renal inflammation.
    The Journal of pathology, 2013, Volume: 231, Issue:4

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Cells, Cultured; Cytokine TWEAK; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Silencing; Heparin-binding EGF-like Growth Factor; Humans; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Kidney Tubules; Ligands; Mice; Mice, Inbred C57BL; Nephritis; NF-kappa B; Phosphorylation; Quinazolines; Receptors, Tumor Necrosis Factor; Signal Transduction; Transcriptional Activation; Transforming Growth Factor alpha; Tumor Necrosis Factors; TWEAK Receptor

2013
[Tumor microenvironment elicits primary resistance to afatinib through HGF secretion].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2013, Volume: 35, Issue:10

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Afatinib; Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Coculture Techniques; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Fibroblasts; Hepatocyte Growth Factor; Humans; Lung; Lung Neoplasms; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Quinazolines; Signal Transduction; Transforming Growth Factor alpha; Tumor Microenvironment; Vimentin

2013
Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells.
    Cellular signalling, 2014, Volume: 26, Issue:5

    Topics: Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Niacinamide; Phenylurea Compounds; Quinazolines; Signal Transduction; Sorafenib; Transforming Growth Factor alpha; Up-Regulation

2014
SR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner.
    Life sciences, 2014, Mar-28, Volume: 100, Issue:1

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Gene Knockdown Techniques; Humans; Lung Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Pyrazoles; Quinazolines; Quinolines; Receptors, Neurotensin; RNA, Small Interfering; Transcriptional Activation; Transforming Growth Factor alpha

2014
The epidermal growth factor receptor is a regulator of epidermal complement component expression and complement activation.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Apr-01, Volume: 192, Issue:7

    Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Complement Activation; Complement System Proteins; Epidermal Cells; Epidermis; ErbB Receptors; Gene Expression; Humans; Keratinocytes; Mice; Microscopy, Fluorescence; Oligonucleotide Array Sequence Analysis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Skin; Transcriptome; Transforming Growth Factor alpha; Tyrphostins

2014
The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-α-EGFR pathway.
    Experimental lung research, 2014, Volume: 40, Issue:7

    Topics: ADAM Proteins; ADAM17 Protein; Antimicrobial Cationic Peptides; Cathelicidins; Cell Line; Epithelial Cells; ErbB Receptors; Humans; Mucin 5AC; Quinazolines; Respiratory Mucosa; Signal Transduction; Transforming Growth Factor alpha; Tyrphostins

2014
Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation.
    European journal of pharmacology, 2014, Dec-15, Volume: 745

    Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Chromones; DNA; Dose-Response Relationship, Drug; Flavonoids; Hepatocytes; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Male; MAP Kinase Signaling System; Morpholines; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Transforming Growth Factor alpha; Tyrphostins

2014
Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis.
    Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:10

    Topics: Animals; Benzoxazines; Cartilage, Articular; Chemokine CCL2; Disease Models, Animal; Disease Progression; Male; Osteoarthritis; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiro Compounds; Transforming Growth Factor alpha; Tyrphostins; Up-Regulation; Wounds and Injuries

2015
Transcriptional Regulation of Human Transforming Growth Factor-α in Astrocytes.
    Molecular neurobiology, 2017, Volume: 54, Issue:2

    Topics: Animals; Astrocytes; Base Sequence; Cells, Cultured; Humans; Quinazolines; Rats; Rats, Sprague-Dawley; Transcription, Genetic; Transforming Growth Factor alpha

2017
Role of EGF receptor ligands in TCDD-induced EGFR down-regulation and cellular proliferation.
    Chemico-biological interactions, 2016, Jun-25, Volume: 253

    Topics: Amphiregulin; Cell Proliferation; Cells, Cultured; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Ligands; Polychlorinated Dibenzodioxins; Protein Binding; Quinazolines; Transforming Growth Factor alpha

2016
The Epidermal Growth Factor Receptor (EGFR) Inhibitor Gefitinib Reduces but Does Not Prevent Tumorigenesis in Chemical and Hormonal Induced Hepatocarcinogenesis Rat Models.
    International journal of molecular sciences, 2016, Sep-23, Volume: 17, Issue:10

    Topics: Animals; Cell Proliferation; Disease Models, Animal; Drug Administration Schedule; ErbB Receptors; Female; Gefitinib; Immunohistochemistry; Islets of Langerhans Transplantation; Liver Neoplasms, Experimental; Male; Nitrosamines; Protein Kinase Inhibitors; Quinazolines; ras Proteins; Rats; Rats, Inbred Lew; Sodium-Glucose Transporter 1; Thyroid Epithelial Cells; TOR Serine-Threonine Kinases; Transforming Growth Factor alpha

2016