quinazolines has been researched along with thymidine monophosphate in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balinska, M; Bunni, M; Galivan, J; Maley, F; Maley, GF; Priest, DG; Rhee, MS | 1 |
| Cranford, SK; Fernandes, DJ | 1 |
| Boschelli, D; Galivan, J; Kerwar, SS; Nimec, Z; Oronsky, AL; Rhee, M | 1 |
| Abels, J; Ermens, AA; Lindemans, J | 1 |
| Garvey, EP; Santi, DV | 1 |
| Danenberg, PV; Lockshin, A; Mondal, K | 1 |
| Connick, TJ; Dunlap, RB; Ellis, PD; Reilly, RT | 1 |
| Appleman, JR; Spencer, HT; Villafranca, JE | 1 |
| Bertino, JR; Li, WW; Tong, WP | 1 |
| Aherne, GW; Barnes, MJ; Calvete, JA; Estlin, EJ; Hardcastle, A; Lunec, J; McGuire, JJ; Newell, DR; Pearson, AD; Taylor, GA | 1 |
| Assaraf, YG; Ifergan, I; Kadry, WN; Pinter, RY | 1 |
| Anderson, KS; Atreya, CE; Doan, LT; Martucci, WE; Vargo, MA | 1 |
| Waldman, AS; Wyatt, MD; Yang, Z | 1 |
| Dong, Y; Guan, Z; Niu, B; Wang, J; Wang, X; Xu, L; Zhang, J; Zhang, T | 1 |
| Hoff, JS; Kristich, CJ | 1 |
15 other study(ies) available for quinazolines and thymidine monophosphate
| Article | Year |
|---|---|
Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells.
Topics: Carcinoma, Hepatocellular; Folic Acid; Liver Neoplasms; Pteroylpolyglutamic Acids; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Trimetrexate; Tumor Cells, Cultured | 1990 |
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
Topics: Deoxyguanine Nucleotides; DNA; DNA Polymerase II; Dose-Response Relationship, Drug; Floxuridine; Folic Acid Antagonists; Humans; Leukemia; Pyrimethamine; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides | 1986 |
Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.
Topics: Acyltransferases; Animals; Drug Synergism; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Liver Neoplasms, Experimental; Phosphoribosylglycinamide Formyltransferase; Pyrimethamine; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Trimetrexate; Tumor Cells, Cultured | 1988 |
Moderate antiproliferative effect of the antifolate CB3717 in the BN myeloid leukaemia model.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; DNA; Fluorouracil; Folic Acid; Folic Acid Antagonists; Leukemia, Myeloid, Acute; Quinazolines; Rats; Thymidine Monophosphate; Thymidylate Synthase | 1988 |
A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction.
Topics: Animals; Binding, Competitive; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Kinetics; Leishmania tropica; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase | 1987 |
Spectroscopic studies of ternary complexes of thymidylate synthetase, deoxyribonucleotides, and folate analogs.
Topics: Deoxyribonucleotides; Floxuridine; Folic Acid; Methyltransferases; Protein Conformation; Pteroylpolyglutamic Acids; Quinazolines; Spectrophotometry; Thymidine Monophosphate; Thymidylate Synthase; Uridine Monophosphate | 1984 |
Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1994 |
Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
Topics: Catalysis; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Ligands; Molecular Structure; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Spectrometry, Fluorescence; Spectrophotometry; Tetrahydrofolates; Thermodynamics; Thymidine Monophosphate; Thymidylate Synthase | 1997 |
Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Division; Cell Survival; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Kinetics; Methotrexate; Purines; Quinazolines; Sarcoma; Tetrahydrofolates; Thiophenes; Thymidine Monophosphate; Tumor Cells, Cultured | 1995 |
Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
Topics: Biological Transport; Cell Division; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Growth Inhibitors; Humans; Inhibitory Concentration 50; Leukemia; Methotrexate; Peptide Synthases; Purines; Quinazolines; RNA, Messenger; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.
Topics: Antimetabolites, Antineoplastic; Computer Simulation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Models, Chemical; Purines; Quinazolines; Signal Transduction; Tetrahydrofolates; Thiophenes; Thymidine Monophosphate | 2006 |
Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Cryptosporidium; Crystallography, X-Ray; Folic Acid; Kinetics; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Protozoan Proteins; Quinazolines; Serine; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 2007 |
DNA damage and homologous recombination signaling induced by thymidylate deprivation.
Topics: Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Flow Cytometry; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Nucleotides; Phosphorylation; Quinazolines; Rad51 Recombinase; Recombination, Genetic; Replication Protein A; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase | 2008 |
Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Deoxyuracil Nucleotides; DNA Damage; Embryo, Mammalian; Female; Folic Acid Antagonists; Gestational Age; Histones; Injections, Intraperitoneal; Male; Mice, Inbred C57BL; Neural Tube Defects; Phosphorylation; Pregnancy; Protein Subunits; Quinazolines; Replication Protein A; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase | 2015 |
Thymidylate Limitation Potentiates Cephalosporin Activity toward Enterococci via an Exopolysaccharide-Based Mechanism.
Topics: Anti-Bacterial Agents; Cell Wall; Cephalosporins; Chloramphenicol; Drug Resistance, Multiple, Bacterial; Drug Synergism; Enterococcus faecalis; Enterococcus faecium; Fluorouracil; Folic Acid Antagonists; Glucose; Polysaccharides; Quinazolines; Tetrahydrofolate Dehydrogenase; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Trimethoprim | 2016 |