quinazolines has been researched along with thiourea in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Rothe, L; Wagner, G | 1 |
| Abdel-Megged, MF; Abdo, MA; Saleh, MA; Shokr, AB | 1 |
| Gama, Y; Shibuya, I; Shimizu, M | 1 |
| Chi, S; Giese, NA; Heath, JA; Hollenbach, SJ; Hutchaleelaha, A; Mehrotra, MM; Pandey, A; Scarborough, RM; Yu, JC | 1 |
| Churg, A; Vincent, R; Wang, RD; Wang, X; Xie, C | 1 |
| Endo, M; Furuta, T; Kubo, K; Miwa, A; Osawa, T; Sakai, T; Senga, T; Shimizu, T; Suzuki, R; Yoshino, T | 1 |
| Fu, L; Li, J; Li, L; Liu, H; Luo, X; Mei, C; Xiong, X | 1 |
| Bearss, D; Cooke, LS; Croce, KD; Mahadevan, D; Qi, W; Riley, C; Saldanha, JW; Stejskal, A | 1 |
| Batra, S; Mishra, A; Puri, SK; Srivastava, K; Tripathi, R | 1 |
| Furukawa, M; Inokuma, T; Matsuzaki, K; Suzuki, Y; Takemoto, Y; Uno, T; Yano, Y; Yoshida, K | 1 |
| Chandna, S; Chopra, M; Chowdhury, J; Kumari, S; Mishra, AK; Saluja, D | 1 |
| Li, S; Ma, JA; Nie, J; Zhang, FG; Zhu, XY | 1 |
| Hu, Y; Tang, JF; Wang, XL; Yang, W; Yang, YS; Zhang, F; Zhang, YB; Zhong, WQ; Zhu, HL | 1 |
| Ebi, H; Ishikawa, D; Matsumoto, K; Nakade, J; Nakagawa, T; Nanjo, S; Sano, T; Takeuchi, S; Yamada, T; Yano, S; Yasumoto, K; Yonekura, K; Zhao, L | 1 |
| Cooke, LS; Kurtzman, D; Mahadevan, D; Morales, C; Ong, E; Qi, W; Stejskal, AE; Swart, R; Theiss, N; Zhu, M | 1 |
| Bierbach, U; Day, CS; Gueble, MJ; Kucera, GL; Pickard, AJ; Qiao, X; Yang, M | 1 |
| Li, G; Yang, B; Yang, N; Yang, YS; Zhu, HL | 1 |
| Bastola, P; Chien, J; Neums, L; Schoenen, FJ | 1 |
| Abadi, AH; Darwish, SS; Engel, M; Hamed, MM; Herrmann, J | 1 |
| Fu, F; Kong, X; Sun, S; Wang, H; Wang, N; Yao, J; Zhang, J | 1 |
| Alagarsamy, V; Chitra, K; Sulthana, MT | 1 |
21 other study(ies) available for quinazolines and thiourea
| Article | Year |
|---|---|
[Synthesis of 2-thiono-4-oxo-1,2,3,4-tetrahydroquinazolines].
Topics: Chemistry, Pharmaceutical; Ethylamines; ortho-Aminobenzoates; Phosgene; Quinazolines; Thiocyanates; Thiourea | 1969 |
Synthesis and antiviral evaluation of some new glycosylthioureas containing a quinazolinone nucleus.
Topics: Antiviral Agents; Carbon Isotopes; HIV; Magnetic Resonance Spectroscopy; Oncogenic Viruses; Quinazolines; Spectrophotometry, Infrared; Thiourea | 2002 |
Novel and efficient synthesis of 4-dimethylamino-2-glycosylaminoquinazolines by cyclodesulfurization of glycosyl thioureas with dimethylcyanamide.
Topics: Aminoquinolines; Cyanamide; Quinazolines; Thiourea | 2002 |
Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor.
Topics: Administration, Oral; Animals; Biological Availability; Dogs; Macaca fascicularis; Quinazolines; Rats; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship; Thiourea | 2004 |
Air pollution particles activate NF-kappaB on contact with airway epithelial cell surfaces.
Topics: Air Pollutants; Animals; Binding, Competitive; Biological Transport; Deferoxamine; Dust; Epithelial Cells; Ferric Compounds; Free Radical Scavengers; In Vitro Techniques; NF-kappa B; Particle Size; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiourea; Time Factors; Titanium; Trachea; Tyrphostins | 2005 |
Identification of potent and selective inhibitors of PDGF receptor autophosphorylation.
Topics: Administration, Oral; Animals; Carotid Stenosis; Cell Line; Male; Phosphorylation; Proto-Oncogene Proteins c-kit; Quinazolines; Quinolines; Rats; Rats, Wistar; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship; Thiourea | 2006 |
Antitumor activity of a new N-substituted thiourea derivative, an EGFR signaling-targeted inhibitor against a panel of human lung cancer cell lines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colony-Forming Units Assay; DNA; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Molecular Structure; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Thiourea | 2008 |
MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Therapy, Combination; ErbB Receptors; Erlotinib Hydrochloride; Humans; Male; Mice; Mice, SCID; Multigene Family; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperazines; Prostatic Neoplasms; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thiourea | 2009 |
Search for new pharmacophores for antimalarial activity. Part III: synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines.
Topics: Animals; Antimalarials; Cell Survival; Chlorocebus aethiops; Female; Malaria; Male; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium yoelii; Quinazolines; Structure-Activity Relationship; Thiourea; Vero Cells | 2009 |
Bifunctional hydrogen-bond donors that bear a quinazoline or benzothiadiazine skeleton for asymmetric organocatalysis.
Topics: Amination; Benzothiadiazines; Catalysis; Combinatorial Chemistry Techniques; Hydrogen Bonding; Models, Chemical; Molecular Structure; Quinazolines; Stereoisomerism; Thiourea | 2011 |
Synthesis and evaluation of a fluorescent non-peptidic cholecystokinin-B/gastrin receptor specific antagonist for cancer cell imaging.
Topics: Animals; Benzodiazepinones; Cells; Chromatography, High Pressure Liquid; Fluoresceins; Fluorescent Dyes; Hormone Antagonists; Inhibitory Concentration 50; Mice; Models, Molecular; Molecular Structure; Neoplasms; Quinazolines; Receptor, Cholecystokinin B; Thiourea; Tumor Cells, Cultured | 2012 |
Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083.
Topics: Anti-HIV Agents; Catalysis; Chemistry Techniques, Synthetic; Imines; Nitriles; Quinazolines; Stereoisomerism; Substrate Specificity; Thiourea | 2012 |
Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Drug Design; ErbB Receptors; Erlotinib Hydrochloride; Humans; MCF-7 Cells; Molecular Conformation; Molecular Docking Simulation; Naphthalenes; Protein Structure, Tertiary; Pyrazoles; Quantitative Structure-Activity Relationship; Quinazolines; Receptor, ErbB-2; Thiourea | 2013 |
Triple inhibition of EGFR, Met, and VEGF suppresses regrowth of HGF-triggered, erlotinib-resistant lung cancer harboring an EGFR mutation.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cell Line, Tumor; Cell Proliferation; Crizotinib; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Hepatocyte Growth Factor; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Phosphorylation; Proto-Oncogene Proteins c-met; Pyrazoles; Pyridines; Quinazolines; Quinolines; Thiourea; Vascular Endothelial Growth Factor A | 2014 |
Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST).
Topics: Afatinib; Aged; Aged, 80 and over; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Female; Gastrointestinal Stromal Tumors; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; Immunoblotting; Immunohistochemistry; Male; Middle Aged; Molecular Targeted Therapy; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-met; Pyrimidines; Quinazolines; Receptor Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Thiourea | 2015 |
Synthesis, reactivity, and biological activity of gold(I) complexes modified with thiourea-functionalized tyrosine kinase inhibitors.
Topics: Afatinib; Cell Line; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Dose-Response Relationship, Drug; Gefitinib; Gold; Humans; Inhibitory Concentration 50; Protein Kinase Inhibitors; Quinazolines; Thiourea | 2015 |
Design, biological evaluation and 3D QSAR studies of novel dioxin-containing pyrazoline derivatives with thiourea skeleton as selective HER-2 inhibitors.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dioxins; Drug Design; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Lapatinib; Molecular Docking Simulation; Protein Kinase Inhibitors; Pyrazoles; Quantitative Structure-Activity Relationship; Quinazolines; Receptor, ErbB-2; Thiourea | 2016 |
VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; Benzimidazoles; Caspases; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cinnamates; Drug Synergism; Endoplasmic Reticulum Stress; Female; Humans; Ovarian Neoplasms; Ovary; Quinazolines; Thiourea; Valosin Containing Protein | 2016 |
First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents.
Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; ErbB Receptors; Female; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Nude; Neoplasms; NF-kappa B; Quinazolines; Signal Transduction; Thiourea | 2017 |
Design and Discovery of Quinazoline- and Thiourea-Containing Sorafenib Analogs as EGFR and VEGFR-2 Dual TK Inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Design; ErbB Receptors; Humans; Melanoma, Experimental; Mice, Inbred C57BL; Molecular Docking Simulation; Protein Binding; Quinazolines; Sorafenib; Thiourea; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2017 |
Design, Synthesis, Pharmacological Evaluation, In silico Modeling, Prediction of Toxicity and Metabolism Studies of Novel 1-(substituted)-2-methyl- 3-(4-oxo-2-phenyl quinazolin-3(4H)-yl)isothioureas.
Topics: Antitubercular Agents; Antiviral Agents; Bacteria; Bacterial Proteins; Drug Design; HIV-1; HIV-2; Microbial Sensitivity Tests; Molecular Docking Simulation; Protein Binding; Quinazolines; Thiourea | 2021 |