quinazolines has been researched along with spautin-1 in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 17 (60.71) | 24.3611 |
| 2020's | 11 (39.29) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, Y; Choi, A; Furuya, T; Hao, Y; Jin, M; Ke, H; Kim, M; Li, Y; Liu, J; Ma, D; Norberg, HV; Wang, H; Xia, H; Xu, L; Yu, J; Yuan, J; Zhang, L; Zhang, T; Zhu, Z | 1 |
| Vakifahmetoglu-Norberg, H; Yuan, J | 1 |
| Bertrand, M; Correa, RJ; DiMattia, GE; Fazio, EN; McGee, J; Peart, TM; Préfontaine, M; Shepherd, TG; Sugimoto, A; Valdes, YR | 1 |
| Bai, H; Li, S; Qin, Y; Shao, S; Wang, C; Wang, X; Yang, Y; Zhao, C; Zhou, L | 1 |
| Eliopoulos, AG; Sourvinos, G; Vlahava, VM | 1 |
| Bílý, T; Elsterová, J; Eyer, L; Palus, M; Růžek, D; Vancová, M | 1 |
| Münz, C; Nytko, KJ; Reichenbach, J; Romao, S; Siler, U; Tejera, E | 1 |
| Fukuoka, N; Horie, R; Mori, M; Nakamura, O; Nishimura, H; Yamagami, Y; Yamamoto, T | 1 |
| Chen, HP; Chen, ZH; Li, ZY; Shen, HH; Wang, Y; Wu, YF; Xu, XC; Zhao, Y; Zhou, JS | 1 |
| Dash, PK; Hood, KN; Hylin, MJ; MacGowan, JS; Moore, AN; Rozas, NS; Tangavelou, K; Zhao, J | 1 |
| Di, W; Jing, Y; Ma, P; Wang, X; Yin, X; Zhang, M; Zhang, S; Zhang, Z; Zhuang, G | 1 |
| Guan, JL; Haas, M; Paul, R; Wang, C; Yeo, SK | 1 |
| Foster, RA; Ludwig, L; Mutsaers, AJ; Schott, CR; Wood, GA | 1 |
| Borchard, S; Concilli, M; Crispino, R; De Cegli, R; Di Schiavi, E; Einer, C; Franco, B; Ilyechova, EY; Indrieri, A; Iorio, R; Kroemer, G; Lichtmannegger, J; Mariniello, M; Merolla, A; Petruzzelli, R; Pietrocola, F; Polishchuk, EV; Polishchuk, RS; Puchkova, LV; Ranucci, G; Romano, A; Schmidt, HH; Zibert, A; Zischka, H | 1 |
| Choi, KS; Kim, JY; Kim, KD; Kwon, YJ; Lee, DM; Lee, HJ; Woo, HG | 1 |
| Guo, Z; Huang, C; Huang, H; Jiang, L; Liao, Y; Liu, J; Liu, Y; Wang, X; Xia, X | 1 |
| Chen, X; Dong, K; Lu, J; Shen, M; Wang, J; Wang, Y; Wei, G; Wu, S; Xie, L; Xu, D; Yang, L; Yu, L | 1 |
| Cao, J; Chen, Z; Dai, X; Gai, R; He, Q; Luo, H; Qian, M; Yan, F; Yang, B; Ye, S; Ying, M; Yuan, T; Zhu, H | 1 |
| Chen, X; Guo, J; Liang, L; Liu, H; Liu, J; Liu, N; Peng, C; Qi, M; Su, J; Zhang, J; Zhao, S | 1 |
| Chen, H; Chen, Z; Lan, F; Li, M; Li, W; Li, Z; Shen, H; Shen, J; Weng, Q; Wu, M; Wu, Y; Xia, L; Xiong, X; Xuan, N; Ying, S; Zhang, B; Zhang, H; Zhao, Y; Zhou, L; Zhu, C | 1 |
| Chen, RY; Lee, YR; Lin, YS; Liu, HS; Wu, SY; Yeh, TM | 1 |
| Ballet, S; De Grève, J; Elsocht, M; Giron, P; Gutierrez, GJ; Maes, L; Versées, W | 1 |
| Bradner, J; Briggs, KJ; Buhrlage, SJ; Dasilva, E; Doench, JG; Donovan, KA; Duplaquet, L; Endress, JE; Fischer, ES; Gray, NS; Gygi, SP; Harris, IS; Ishoey, M; Kaelin, WG; Koduri, V; Lampson, BL; Liu, X; Medin, JA; Oser, MG; Ott, CJ; Paulk, J; Paulo, JA; Sabet, AH; Teng, M; Wang, AC; Zhang, T | 1 |
| Hou, J; Wang, Y; Wu, H; Xue, Y; Zhang, Y | 1 |
| Cen, X; Hou, T; Najafov, A; Peng, D; Shan, B; Sun, Q; Sun, Y; Wang, Z; Xia, H; Xie, T; Xu, X; Xue, Y; Yi, C; Zhang, M; Zhao, Q | 1 |
| Ji, J; Li, Y; Wang, X; Ye, SD; Yu, Y; Zhang, M; Zhang, X; Zhang, Y; Zhu, Z | 1 |
| Dan, S; Ikeda-Ishikawa, C; Koido, M; Kunimasa, K; Okamoto, Y; Sakurai, J; Tani, Y; Tomida, A; Tsukahara, S | 1 |
| Ballet, S; De Grève, J; Elsocht, M; Giron, P | 1 |
28 other study(ies) available for quinazolines and spautin-1
| Article | Year |
|---|---|
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Benzylamines; Class III Phosphatidylinositol 3-Kinases; Endopeptidases; Humans; Mice; Quinazolines; Tumor Suppressor Protein p53; Ubiquitin Thiolesterase; Ubiquitin-Specific Proteases; Ubiquitination | 2011 |
A degradative detour for mutant TP53.
Topics: Antineoplastic Agents; Autophagy; Benzylamines; Humans; Molecular Chaperones; Mutant Proteins; Neoplasms; Proteasome Endopeptidase Complex; Proteolysis; Quinazolines; Signal Transduction; Tumor Suppressor Protein p53; Ubiquitination | 2013 |
Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability.
Topics: Allosteric Regulation; Antineoplastic Agents; Ascites; Autophagy; Benzylamines; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Inhibitory Concentration 50; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; Quinazolines; Quinoxalines; Spheroids, Cellular | 2014 |
Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Benzamides; Benzylamines; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Piperazines; Pyrimidines; Quinazolines | 2014 |
CD40 ligand exhibits a direct antiviral effect on Herpes Simplex Virus type-1 infection via a PI3K-dependent, autophagy-independent mechanism.
Topics: Anthracenes; Antiviral Agents; Autophagy; Autophagy-Related Protein 5; Benzylamines; CD40 Ligand; Cell Line, Tumor; Cell Nucleus; Chromones; Herpes Simplex Virus Protein Vmw65; Herpesvirus 1, Human; Humans; JNK Mitogen-Activated Protein Kinases; Macrolides; Microtubule-Associated Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Virus Replication | 2015 |
Electron Tomography Analysis of Tick-Borne Encephalitis Virus Infection in Human Neurons.
Topics: Animals; Autophagy; Benzylamines; Cell Line, Tumor; Electron Microscope Tomography; Encephalitis Viruses, Tick-Borne; Endoplasmic Reticulum; Humans; Microtubules; Neurons; Nocodazole; Primary Cell Culture; Quinazolines; Sirolimus; Virion; Virus Replication | 2015 |
Defective nuclear entry of hydrolases prevents neutrophil extracellular trap formation in patients with chronic granulomatous disease.
Topics: Adenine; Androstadienes; Benzylamines; Candida albicans; Cell Nucleus; Extracellular Traps; Granulomatous Disease, Chronic; Histones; Humans; Hydrolases; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Wortmannin | 2015 |
Apoptosis and antitumor effects induced by the combination of an mTOR inhibitor and an autophagy inhibitor in human osteosarcoma MG63 cells.
Topics: Apoptosis; Autophagy; Benzylamines; Cell Line, Tumor; Cell Proliferation; Humans; Osteosarcoma; Phosphorylation; Quinazolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2016 |
Autophagy inhibitors suppress environmental particulate matter-induced airway inflammation.
Topics: Adenine; Animals; Autophagy; Benzylamines; Cell Line; Cytokines; Environmental Pollutants; Gene Expression Regulation; Humans; Inflammation; Mice; Mice, Inbred C57BL; Particulate Matter; Quinazolines | 2017 |
A role for autophagy in long-term spatial memory formation in male rodents.
Topics: Adenine; Animals; Antigens, Nuclear; Autophagy; Beclin-1; Benzylamines; Glial Fibrillary Acidic Protein; Hippocampus; Male; Maze Learning; Memory, Long-Term; Memory, Short-Term; Mice; Microtubule-Associated Proteins; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinase; Phosphorylation; Quinazolines; Rats; Rats, Long-Evans; Spatial Memory | 2018 |
Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors.
Topics: Aniline Compounds; Animals; bcl-X Protein; Benzylamines; Cell Line, Tumor; CRISPR-Cas Systems; Endopeptidases; HEK293 Cells; Humans; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Quinazolines; RNA Interference; Sulfonamides; Ubiquitin-Specific Proteases; Ubiquitination; Xenograft Model Antitumor Assays | 2018 |
Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.
Topics: Animals; Autophagy; Autophagy-Related Proteins; Benzylamines; BRCA1 Protein; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Intracellular Signaling Peptides and Proteins; Mammary Neoplasms, Animal; Metformin; Mice; Mitochondria; Models, Biological; Organelle Biogenesis; Oxidative Stress; Phosphorylation; Quinazolines; Substrate Specificity; TOR Serine-Threonine Kinases; Treatment Outcome | 2018 |
The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells.
Topics: Animals; Autophagy; Benzylamines; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Dogs; Doxorubicin; Drug Interactions; Inhibitory Concentration 50; Osteosarcoma; Quinazolines | 2018 |
Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis.
Topics: Animals; Apoptosis; Autophagosomes; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Benzylamines; Cell Survival; Copper; Copper-Transporting ATPases; Female; Hep G2 Cells; Hepatocytes; Hepatolenticular Degeneration; Humans; Liver; Male; Mice; Mice, Knockout; Microscopy, Confocal; Microscopy, Electron; Mitochondria; Protein Transport; Quinazolines; Rats; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
RNAi Screening-based Identification of USP10 as a Novel Regulator of Paraptosis.
Topics: Antineoplastic Agents; Benzylamines; Breast Neoplasms; Cell Death; Cell Line, Tumor; Curcumin; Endoplasmic Reticulum; Female; Gene Library; High-Throughput Screening Assays; Humans; Membrane Potential, Mitochondrial; Mitochondria; Quinazolines; RNA Interference; RNA, Small Interfering; Ubiquitin Thiolesterase | 2019 |
Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer.
Topics: Animals; Apoptosis; Autophagy; Benzamides; Benzylamines; Biomarkers, Tumor; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Disease Models, Animal; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Glucose; Glucose Transporter Type 1; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mice; Models, Biological; Molecular Targeted Therapy; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2019 |
Spautin-A41 Attenuates Cerulein-Induced Acute Pancreatitis through Inhibition of Dysregulated Autophagy.
Topics: Animals; Apoptosis; Autophagy; Benzylamines; Cell Line; Ceruletide; Male; Mice; Mice, Inbred C57BL; Pancreas; Pancreatitis; Phosphatidylinositol 3-Kinases; Quinazolines; Rats | 2019 |
Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein.
Topics: Animals; Benzylamines; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Protein Binding; Protein Stability; Quinazolines; RNA, Small Interfering; Smad4 Protein; Transforming Growth Factor beta; Ubiquitin Thiolesterase; Ubiquitination; Xenograft Model Antitumor Assays | 2020 |
Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzylamines; Cell Line, Tumor; Cisplatin; DNA Damage; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Melanoma, Cutaneous Malignant; Mice; Quinazolines; Reactive Oxygen Species; Skin Neoplasms; Ubiquitin Thiolesterase; Ubiquitin-Specific Proteases; Xenograft Model Antitumor Assays | 2020 |
Induction of ferroptosis-like cell death of eosinophils exerts synergistic effects with glucocorticoids in allergic airway inflammation.
Topics: Animals; Artesunate; Benzylamines; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dexamethasone; Drug Synergism; Eosinophils; Ferroptosis; Glucocorticoids; Humans; Imidazoles; Indoles; Male; Mice; Mice, Inbred C57BL; Piperazines; Quinazolines | 2020 |
Regulation of autophagy, glucose uptake, and glycolysis under dengue virus infection.
Topics: A549 Cells; Amiodarone; Animals; Animals, Newborn; Autophagy; Autophagy-Related Protein 5; Benzylamines; Biological Transport; Brain; Chlorocebus aethiops; Dengue; Dengue Virus; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; Glycolysis; Hexokinase; Host-Pathogen Interactions; Humans; Mice; Mice, Inbred ICR; Microtubule-Associated Proteins; Phosphofructokinases; Quinazolines; Signal Transduction; Vero Cells; Virus Replication | 2020 |
Structure-Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors.
Topics: Antineoplastic Agents; Benzylamines; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Humans; Lung Neoplasms; Molecular Targeted Therapy; Mutation; Neoplasm Proteins; NIMA-Related Kinases; Quinazolines; Structure-Activity Relationship | 2021 |
Targeting oncoproteins with a positive selection assay for protein degraders.
Topics: Adaptor Proteins, Signal Transducing; Basic Helix-Loop-Helix Transcription Factors; Benzylamines; CRISPR-Cas Systems; Humans; Ikaros Transcription Factor; Oncogene Proteins; Proteolysis; Quinazolines; Thalidomide; Transcription Factors | 2021 |
PTH1-34 promotes osteoblast formation through Beclin1-dependent autophagic activation.
Topics: Adenine; Animals; Autophagy; Beclin-1; Benzylamines; Cell Differentiation; Cell Line; Cell Proliferation; Estradiol; Female; Mice; Osteoblasts; Osteogenesis; Ovariectomy; Parathyroid Hormone; Quinazolines; Rats, Sprague-Dawley | 2021 |
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Benzylamines; Cell Line, Tumor; Chaperone-Mediated Autophagy; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; HeLa Cells; HSC70 Heat-Shock Proteins; Humans; I-kappa B Kinase; Isoenzymes; Male; MAP Kinase Kinase Kinases; Metformin; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; PC12 Cells; Phenylurea Compounds; Quinazolines; Rats; Signal Transduction | 2021 |
Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells.
Topics: Animals; Benzylamines; Cell Line; Humans; Induced Pluripotent Stem Cells; MAP Kinase Signaling System; Mice; Mouse Embryonic Stem Cells; Proto-Oncogene Proteins c-raf; Quinazolines; Ubiquitin-Specific Proteases | 2021 |
Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation.
Topics: Benzylamines; Cell Survival; Endoplasmic Reticulum Stress; Glucose; Quinazolines; Unfolded Protein Response | 2022 |
Second generation Spautin-1 analogues targeting EGFR-mutant non-small cell lung cancer cells.
Topics: Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Humans; Lung Neoplasms; Quinazolines | 2023 |