quinazolines has been researched along with sotrastaurin in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (6.94) | 29.6817 |
| 2010's | 62 (86.11) | 24.3611 |
| 2020's | 5 (6.94) | 2.80 |
| Authors | Studies |
|---|---|
| Baier, G; Brinkmann, V; Cottens, S; Evenou, JP; Gruber, T; Guntermann, C; Hermann-Kleiter, N; Kaminski, S; Kovarik, J; Letschka, T; Lutz-Nicoladoni, C; Thuille, N; Towbin, H; Wagner, J; Wagner, K; Weitz-Schmidt, G; Welzenbach, KA; Zenke, G | 1 |
| Chandler, PA; Huang, HL; Kovarik, JM; Sfikas, N; Slade, A | 1 |
| Albert, R; Beerli, C; Cooke, N; Cottens, S; Cowan-Jacob, SW; Ehrhardt, C; Evenou, JP; Geiser, M; Rummel, G; Sedrani, R; Stark, W; Strauss, A; von Matt, P; Wagner, J; Weckbecker, G; Zenke, G | 1 |
| Manicassamy, S | 1 |
| Sommerer, C; Zeier, M | 1 |
| Blankesteijn, WM; Smits, JF; Verkaar, F; Zaman, GJ | 1 |
| Beerli, C; Bruns, C; Burkhart, C; Metzler, B; Morris, RE; Pally, C; Wagner, J; Weckbecker, G; Wieczorek, G | 1 |
| Budde, K; Kramer, S; Ladhoff, J; Lorkowski, C; Mashreghi, MF; Matz, M; Neumayer, HH; Weber, U | 1 |
| Asderakis, A; Barten, MJ; Becker, T; Budde, K; Dantal, J; Grinyo, JM; Ng, J; Pietruck, F; Rigotti, P; Sommerer, C; Weber, M | 1 |
| Antunes, MC; Bartlett, M; Kovarik, JM; Marbach, P; Rordorf, C; van Marle, S; Winter, S | 1 |
| Grenet, O; Kovarik, JM; Seiberling, M; Sfikas, N; Slade, A; Stitah, S; Straube, F; Vitaliti, A; Winter, S | 2 |
| Cooper, JE; Wiseman, AC | 1 |
| Fang, YH; Jeong, HJ; Joo, DJ; Kim, JY; Kim, MS; Kim, YS; Lim, BJ | 1 |
| Kovarik, JM; Slade, A | 1 |
| Cillo, U; Gatlik, E; Kovarik, JM; Meiser, K; Neuhaus, P; Slade, A; Stitah, S; Weber, M | 1 |
| Budde, K; Glander, P; Mashreghi, MF; Matz, M; Naik, M; Neumayer, HH | 1 |
| Arns, W; Budde, K; Dantal, J; Grinyo, JM; Kovarik, JM; Proot, P; Rostaing, L; Steiger, JU | 1 |
| Chen, L; Dörken, B; Enns, A; Lenz, G; Lenz, P; Loo, A; Naylor, TL; Ratsch, BA; Schuler, W; Stegmeier, F; Tang, H; Warmuth, M; Waters, NJ; Yao, YM | 1 |
| Abrams, K; Arns, W; Banas, B; Budde, K; Chan, L; Cibrik, D; Friman, S; Klempnauer, J; Mulgaonkar, S; Nashan, B; Nicholson, M; Vincenti, F; Wahlberg, J; Wissing, KM; Witte, S; Woodle, ES | 1 |
| Kaplan, B; Meier-Kriesche, HU | 1 |
| Chastain, EM; Getts, DR; Getts, MT; Martin, A; Miller, SD; Shankar, S; Wood, K | 1 |
| Albert, R; Beerli, C; Cooke, NG; Cottens, S; Evenou, JP; Faller, B; Jean, C; Sedrani, R; von Matt, P; Wagner, J; Weckbecker, G; Wiegand, H; Zenke, G | 1 |
| Fang, YH; Huh, KH; Joo, DJ; Kim, MS; Kim, YS; Lim, BJ; Suh, H | 1 |
| Busuttil, RW; Kamo, N; Ke, B; Kupiec-Weglinski, JW; Shen, XD | 1 |
| Becker, T; Chicano Wust, I; Ciesek, S; Heidrich, B; Helfritz, FA; Manns, MP; Pietschmann, T; Rohrmann, K; Schulze, A; Steinmann, E; Urban, S; von Hahn, T | 1 |
| Todo, S; Yamashita, K | 1 |
| Audet, M; Beerli, C; Bigaud, M; Blancher, A; Heusser, C; Morris, RE; Wagner, J; Wieczorek, G | 1 |
| Altman, A; Kong, KF | 1 |
| Chudasama, J; Guttikar, S; Guy, B; Jakab, A; Kovarik, JM; Kretz, O; Picard, F; Raccuglia, M; Singhal, P; Winter, S | 1 |
| Fletcher, JA; Hodi, FS; Li, J; Wu, X; Zhu, M | 1 |
| Budde, K; Doueiri, S; Fabritius, K; Lehnert, M; Lorkowski, C; Mashreghi, MF; Matz, M; Neumayer, HH; Unterwalder, N; Weber, UA | 1 |
| Catar, R; Chaykovska, L; Dragun, D; Fuller, TF; Haller, M; Hoff, U; Kusch, A; Pützer, J; Troppmair, J | 1 |
| Klintmalm, GB; Ruiz, R | 1 |
| Beckebaum, S; Cicinnati, VR; Kabar, I; Radtke, A | 1 |
| Budde, K; Fabritius, K; Lehnert, M; Lorkowski, C; Mashreghi, MF; Matz, M; Neumayer, HH; Weber, UA | 1 |
| Baan, CC; Kraaijeveld, R; Vafadari, R; Weimar, W | 1 |
| Budde, K; Campistol, JM; Eris, J; Gopalakrishnan, U; Hartmann, A; Kho, MM; Klupp, J; Krishnan, I; Rostaing, L; Russ, G; Tedesco-Silva, H; Vitko, S | 1 |
| Budde, K; Chodoff, L; Cohney, S; Eris, J; Gill, J; Klupp, J; Kuypers, DR; Langer, RM; Ng, J; Russ, GR; Sommerer, C; Tedesco-Silva, H; von Zur-Mühlen, B; Witzke, O; Woodle, ES | 1 |
| Baan, C; de Weerd, A; Kho, M; Kraaijeveld, R; Weimar, W; Zuiderwijk, J | 1 |
| Bossart, W; Etter, A; Fehr, T; Hässig, A; Müller, N; Roos, M; Schiesser, M; Wüthrich, RP | 1 |
| Bastian, BC; Chen, X; Emery, C; Jager, MJ; Porter, D; Tan, L; Wu, Q | 1 |
| Boots, AMH; He, X; Joosten, I; Keijsers, R; Koenen, HJPM; Koerber, A; Smeets, RL; van de Kerkhof, PC; van Rijssen, E | 1 |
| Bhang, HE; Chan, FC; Cooke, VG; Derti, A; Dietze, K; Dörken, B; Farsidjani, A; Frick, M; Fritsch, C; Gascoyne, RD; Hummel, M; Kauffmann, A; Kim, S; Korn, JM; Kovats, S; Kridel, R; Lenz, G; Meissner, B; Monahan, J; Morrissey, MP; Naylor, T; Pfister, E; Rahal, R; Rakiec, D; Romero, R; Ruddy, D; Sellers, WR; Stegmeier, F; Steidl, C; Tzankov, A | 1 |
| Ambrosini, G; de Stanchina, E; Musi, E; Schwartz, GK | 1 |
| Andritsos, L; Awan, FT; Blachly, JS; Byrd, JC; Cannon, M; Chen, CS; El-Gamal, D; Jones, J; LaFollette, TD; Lapalombella, R; Lehman, A; Maddocks, K; Williams, E; Williams, K; Woyach, JA; Wu, CH; Zhang, X; Zhong, Y | 1 |
| Chan, SH; Chu, PM; Hung, CH; Tsai, KL | 1 |
| Bijarnia, M; De Simone, P; Isoneimi, H; Klupp, J; Krishnan, I; Pascher, A; Pirenne, J; Pratschke, J; Salamé, E | 1 |
| Hamburger, AW; Lee, Y; Mitchell, BS; Nguyen, le XT; Sunwoo, JB; Urbani, L; Utz, PJ | 1 |
| Adamus, G; Amundson, D; Boon, CJ; Haanen, JB; Jager, MJ; Kapiteijn, EH; Keunen, JE; Luyten, GP; Marinkovic, M; van Dijk, EH; van Herpen, CM | 1 |
| Acaz-Fonseca, E; Garcia-Segura, LM; Ghorbanpoor, S; Grassi, D; Ruiz-Palmero, I | 1 |
| Cheng, XD; Feng, L; Gu, JF; Jia, XB; Yuan, JR | 1 |
| Ott, G; Rauert-Wunderlich, H; Rosenwald, A; Rudelius, M | 1 |
| Aguiar, W; Campos, E; Cristelli, M; Felipe, C; Ferreira, A; Franco, M; Gerbase de Lima, M; Hannun, P; Medina-Pestana, J; Sandes-Freitas, T; Tedesco-Silva, H | 1 |
| Vincenti, F; Webber, AB | 1 |
| Atsumi, T; Ishizu, A; Kusunoki, Y; Miyoshi, A; Miyoshi, H; Nakamura, A; Nakazawa, D; Shida, H; Tomaru, U; Yamada, M | 1 |
| Carita, G; Cassoux, N; Dahmani, A; De Koning, L; Decaudin, D; Emery, C; Frisch-Dit-Leitz, E; Halilovic, E; Jeay, S; Laurent, C; Némati, F; Piperno-Neumann, S; Raymondie, C; Roman-Roman, S; Schoumacher, M; Wylie, A | 1 |
| Abdelnabi, R; Delang, L; Leyssen, P; Near, KE; Neyts, J; Staveness, D; Wender, PA | 1 |
| Bañon-Maneus, E; Campistol, JM; Diekmann, F; Hierro-Garcia, N; Martina, MN; Moya Rull, D; Ramirez Bajo, MJ; Revuelta, I; Rovira, J | 1 |
| Abdelnabi, R; Amrun, SN; Delang, L; Leyssen, P; Neyts, J; Ng, LF | 1 |
| Dholakia, S; Fildes, JE; Friend, PJ | 1 |
| Amrouche, K; Jamin, C | 1 |
| Bu, W; Chang, G; Chang, S; Dai, B; Hou, J; Hu, L; Kong, Y; Lan, X; Shi, J; Tao, Y; Wang, Y; Wei, Q; Wu, H; Xiao, W; Xie, B; Xie, Y; Yang, G; Yu, D; Zheng, J | 1 |
| Cao, Y; Deng, X; Feng, C; Li, C; Li, G; Li, H; Li, S; Liu, L; Yu, D | 1 |
| Katayama, K; Noguchi, K; Sugimoto, Y; Takami, M | 1 |
| Abedini, S; Pasdar, A; Rivandi, M; Sahebkar, A; Tajbakhsh, A | 1 |
| Rongrong, S; Sun, S; Xiaowu, L; Yangmei, Z; Youwei, Z; Yuan, Y | 1 |
| Bai, M; Dong, Y; Han, S; Ma, J; Sun, X; Zhou, C | 1 |
| Han, C; He, L; Lei, D; Li, S; Liu, L; Ma, T; Wen, S; Xie, S; Zhou, H | 1 |
| Lu, X; Luo, S; Pang, C; Qin, H; Wen, L; Zhu, B | 1 |
| Chen, B; Guan, YX; Huang, W; Jing, F; Ma, Q; Wu, CJ; Xu, SJ | 1 |
| Albert, V; Brockhoff, G; Gaumann, A; Hummel, M; Jagla, W; Lammert, H; Ortmann, O; Piendl, G; Wege, AK; Yousseff, D | 1 |
12 review(s) available for quinazolines and sotrastaurin
| Article | Year |
|---|---|
Sotrastaurin, a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
Topics: Animals; Clinical Trials as Topic; Graft Rejection; Humans; Organ Transplantation; Protein Kinase C; Protein Kinase Inhibitors; Psoriasis; Pyrroles; Quinazolines | 2009 |
AEB071--a promising immunosuppressive agent.
Topics: Clinical Trials as Topic; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines | 2009 |
Novel immunosuppressive agents in kidney transplantation.
Topics: Abatacept; Alefacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cyclosporine; Everolimus; Graft Rejection; Graft Survival; Humans; Immunoconjugates; Immunosuppressive Agents; Kidney Transplantation; Piperidines; Pyrimidines; Pyrroles; Quinazolines; Recombinant Fusion Proteins; Sirolimus | 2010 |
Overview of sotrastaurin clinical pharmacokinetics.
Topics: Biomarkers; Drug Interactions; Drug Monitoring; Graft Rejection; Humans; Immunosuppressive Agents; Lymphocyte Activation; Organ Transplantation; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; T-Lymphocytes | 2010 |
Evaluation of the novel protein kinase C inhibitor sotrastaurin as immunosuppressive therapy after renal transplantation.
Topics: Calcineurin Inhibitors; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cyclosporine; Drug Evaluation; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Mycophenolic Acid; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Sirolimus; Tacrolimus; Treatment Outcome | 2011 |
Current landscape for T-cell targeting in autoimmunity and transplantation.
Topics: Autoimmune Diseases; Calcineurin Inhibitors; Cell Differentiation; Cell Proliferation; Cytokines; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Janus Kinase 3; Organ Transplantation; Piperidines; Protein Kinase C; Pyrimidines; Pyrroles; Quinazolines; Receptors, Cytokine; T-Lymphocytes; Transplantation Immunology; Transplantation Tolerance | 2011 |
Renal-sparing regimens employing new agents.
Topics: Abatacept; Calcineurin Inhibitors; Cyclosporine; Everolimus; Graft Rejection; Humans; Immunoconjugates; Immunosuppressive Agents; Kidney; Kidney Transplantation; Mycophenolic Acid; Pyrroles; Quinazolines; Sirolimus; TOR Serine-Threonine Kinases | 2012 |
Calcineurin inhibitors in liver transplantation - still champions or threatened by serious competitors?
Topics: Abatacept; Calcineurin Inhibitors; Everolimus; Humans; Immunoconjugates; Immunosuppression Therapy; Liver Transplantation; Mycophenolic Acid; Precision Medicine; Pyrroles; Quinazolines; Renal Insufficiency; Risk Factors; Sirolimus; Tacrolimus; TOR Serine-Threonine Kinases | 2013 |
An Update on Calcineurin Inhibitor-Free Regimens: The Need Persists, but the Landscape has Changed.
Topics: Abatacept; Animals; Calcineurin Inhibitors; Drug Therapy, Combination; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Molecular Targeted Therapy; Organ Transplantation; Piperidines; Pyrimidines; Pyrroles; Quinazolines; Risk Assessment; Risk Factors; Signal Transduction; Time Factors; Treatment Outcome | 2016 |
The use of kinase inhibitors in solid organ transplantation.
Topics: Aminopyridines; Humans; Immunosuppressive Agents; Indoles; Morpholines; Organ Transplantation; Oxazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sunitinib; Syk Kinase | 2017 |
Influence of drug molecules on regulatory B cells.
Topics: Adrenal Cortex Hormones; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; B-Cell Activating Factor; B-Lymphocytes, Regulatory; CD40 Antigens; Cytokines; Humans; Immunosuppressive Agents; Methotrexate; Mycophenolic Acid; Pyrroles; Quinazolines; Receptors, Antigen, B-Cell; Semaphorins; Sirolimus; Toll-Like Receptors; Tretinoin; Vitamin D; Vitamins | 2017 |
Regulators and mechanisms of anoikis in triple-negative breast cancer (TNBC): A review.
Topics: Anoikis; Berberine; Chlorobenzoates; Female; Gene Expression Regulation, Neoplastic; Humans; Pyrans; Pyrroles; Quinazolines; Saponins; Signal Transduction; Styrenes; Triple Negative Breast Neoplasms | 2019 |
12 trial(s) available for quinazolines and sotrastaurin
| Article | Year |
|---|---|
Sotrastaurin, a novel small molecule inhibiting protein kinase C: first clinical results in renal-transplant recipients.
Topics: Adult; Aged; Biopsy; Female; Glomerular Filtration Rate; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Tacrolimus; Treatment Outcome | 2010 |
Sotrastaurin and everolimus pharmacokinetics after single-dose coadministration.
Topics: Administration, Oral; Adult; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Interactions; Everolimus; Humans; Immunosuppressive Agents; Male; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Sirolimus; Young Adult | 2010 |
Sotrastaurin and tacrolimus coadministration: effects on pharmacokinetics and biomarker responses.
Topics: Adult; Area Under Curve; Biomarkers; Calcium; Cell Proliferation; Cross-Over Studies; Drug Interactions; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Lymphocytes; Male; Protein Kinase C; Pyrroles; Quinazolines; RNA, Messenger; T-Lymphocytes; Tacrolimus; Tumor Necrosis Factor-alpha; Young Adult | 2010 |
Sotrastaurin and cyclosporine drug interaction study in healthy subjects.
Topics: Adult; Biomarkers, Pharmacological; Cyclosporine; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Humans; Lymphocyte Activation; Male; Pyrroles; Quinazolines; T-Lymphocytes | 2010 |
Sotrastaurin single-dose pharmacokinetics in de novo liver transplant recipients.
Topics: Female; Graft Rejection; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Protein Kinase C; Pyrroles; Quinazolines | 2011 |
Pharmacokinetics of sotrastaurin combined with tacrolimus or mycophenolic acid in de novo kidney transplant recipients.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Female; Follow-Up Studies; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Longitudinal Studies; Male; Middle Aged; Mycophenolic Acid; Prospective Studies; Pyrroles; Quinazolines; Tacrolimus; Treatment Outcome; Young Adult | 2011 |
Sotrastaurin, a novel small molecule inhibiting protein-kinase C: randomized phase II study in renal transplant recipients.
Topics: Adult; Calcineurin Inhibitors; Female; Humans; Kidney Transplantation; Male; Mycophenolic Acid; Protein Kinase C; Pyrroles; Quinazolines; Tacrolimus | 2011 |
Sotrastaurin in calcineurin inhibitor-free regimen using everolimus in de novo kidney transplant recipients.
Topics: Acute Disease; Adult; Antineoplastic Agents; Biopsy; Calcineurin Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Everolimus; Female; Follow-Up Studies; Glomerular Filtration Rate; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Male; Middle Aged; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Retrospective Studies; Sirolimus; Transplantation, Homologous; Treatment Outcome | 2013 |
Efficacy of sotrastaurin plus tacrolimus after de novo kidney transplantation: randomized, phase II trial results.
Topics: Biopsy; Dose-Response Relationship, Drug; Drug Therapy, Combination; Follow-Up Studies; Glomerular Filtration Rate; Graft Rejection; Immunosuppressive Agents; Kidney; Kidney Transplantation; Pyrroles; Quinazolines; Retrospective Studies; Tacrolimus; Treatment Outcome | 2013 |
The protein kinase C inhibitor sotrastaurin allows regulatory T cell function.
Topics: Adult; CD4 Antigens; Cell Proliferation; Cyclosporine; Female; Flow Cytometry; Forkhead Transcription Factors; Humans; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Kidney Transplantation; Lymphocyte Count; Lymphocyte Culture Test, Mixed; Male; Middle Aged; NF-kappa B; Phosphorylation; Protein Kinase C; Pyrroles; Quinazolines; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes, Regulatory | 2014 |
Protein kinase C inhibitor sotrastaurin in de novo liver transplant recipients: a randomized phase II trial.
Topics: Adult; Aged; Biopsy; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Graft Rejection; Humans; Immunosuppressive Agents; Incidence; Kaplan-Meier Estimate; Kidney Transplantation; Liver Failure; Liver Transplantation; Male; Middle Aged; Protein Kinase C; Pyrroles; Quinazolines; Tacrolimus; Time Factors; Treatment Outcome | 2015 |
Serous Retinopathy Associated with Mitogen-Activated Protein Kinase Kinase Inhibition (Binimetinib) for Metastatic Cutaneous and Uveal Melanoma.
Topics: Adult; Aged; Autoantibodies; Benzimidazoles; Central Serous Chorioretinopathy; Cross-Sectional Studies; Drug Combinations; Electrooculography; Electroretinography; Eye Proteins; Female; Fluorescein Angiography; Humans; Male; Melanoma; Melanoma, Cutaneous Malignant; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Prospective Studies; Protein Kinase C; Pyrroles; Quinazolines; Skin Neoplasms; Subretinal Fluid; Tomography, Optical Coherence; Uveal Neoplasms; Visual Acuity | 2015 |
48 other study(ies) available for quinazolines and sotrastaurin
| Article | Year |
|---|---|
The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.
Topics: Animals; Calcium; CD28 Antigens; Cell Adhesion; Cytokines; Electrophoretic Mobility Shift Assay; Flow Cytometry; Genes, Reporter; Humans; Immunosuppressive Agents; Isoenzymes; Jurkat Cells; Macrophage Activation; Mice; Mice, Knockout; NF-kappa B; NFATC Transcription Factors; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes | 2009 |
The effect on sotrastaurin pharmacokinetics of strong CYP3A inhibition by ketoconazole.
Topics: Administration, Oral; Adult; Antifungal Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Half-Life; Humans; Immunosuppressive Agents; Ketoconazole; Male; Pyrroles; Quinazolines; Young Adult | 2009 |
Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Topics: Animals; Clinical Trials as Topic; Drug Discovery; Humans; Isoenzymes; Maleimides; Mice; Models, Molecular; Molecular Conformation; Molecular Weight; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Rats; Substrate Specificity; T-Lymphocytes; Transplantation Tolerance | 2009 |
beta-Galactosidase enzyme fragment complementation for the measurement of Wnt/beta-catenin signaling.
Topics: Animals; beta Catenin; beta-Galactosidase; Cell Polarity; Cell Proliferation; Down-Regulation; Genetic Complementation Test; Glycogen Synthase Kinase 3; Humans; Jurkat Cells; Mice; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Signal Transduction; TCF Transcription Factors; Transcription, Genetic; Transgenes; Wnt Proteins; Wnt-5a Protein; Wnt3 Protein; Wnt3A Protein | 2010 |
Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.
Topics: Animals; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Everolimus; Fingolimod Hydrochloride; Heart Transplantation; Immunosuppressive Agents; Male; Propylene Glycols; Protein Kinase C; Pyrroles; Quinazolines; Rats; Rats, Inbred Lew; Rats, Wistar; Sirolimus; Sphingosine | 2010 |
Effects of the new immunosuppressive agent AEB071 on human immune cells.
Topics: CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cytokines; Dendritic Cells; Humans; Immunosuppressive Agents; Ionomycin; K562 Cells; Killer Cells, Natural; Leukocytes, Mononuclear; Protein Kinase C; Pyrroles; Quinazolines; Tetradecanoylphorbol Acetate | 2010 |
AEB-071 versus tacrolimus monotherapy to prevent acute cardiac allograft rejection in the rat: a preliminary report.
Topics: Animals; Graft Rejection; Graft Survival; Heart Transplantation; Lymphocyte Activation; Male; Myocardial Contraction; Pyrroles; Quinazolines; Rats; Rats, Inbred BN; Rats, Inbred Lew; T-Lymphocytes; Tacrolimus; Transplantation, Heterotopic; Transplantation, Homologous | 2010 |
Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.
Topics: Animals; CARD Signaling Adaptor Proteins; CD79 Antigens; Cell Growth Processes; Cell Line, Tumor; G1 Phase; Guanylate Cyclase; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; Mutation; NF-kappa B; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcr; Pyrroles; Quinazolines; Signal Transduction | 2011 |
The search for CNI-free immunosuppression: no free lunch.
Topics: Female; Humans; Kidney Transplantation; Male; Protein Kinase C; Pyrroles; Quinazolines | 2011 |
Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
Topics: Animals; Cells, Cultured; Graft Rejection; Humans; Lymphocyte Activation; Macaca fascicularis; Mice; Mice, Inbred BALB C; Protein Kinase C; Protein Kinase Inhibitors; Psoriasis; Pyrroles; Quinazolines; Rats; Structure-Activity Relationship; Tissue Distribution | 2011 |
The effects of AEB071 (sotrastaurin) with tacrolimus on rat heterotopic cardiac allograft rejection and survival.
Topics: Acute Disease; Animals; Disease Models, Animal; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Kidney; Liver; Male; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Transplantation, Heterotopic; Transplantation, Homologous | 2011 |
Sotrastaurin, a protein kinase C inhibitor, ameliorates ischemia and reperfusion injury in rat orthotopic liver transplantation.
Topics: Animals; Apoptosis; Cell Proliferation; Cold Ischemia; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Liver Transplantation; Male; NF-kappa B; Protein Kinase C; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; T-Lymphocytes | 2011 |
The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus.
Topics: Calcineurin; Calcineurin Inhibitors; Cell Line, Tumor; Cyclosporine; Hepacivirus; Hepatitis B virus; Humans; Immunosuppressive Agents; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; RNA, Viral; Virus Internalization; Virus Replication | 2011 |
Sotrastaurin, a new selective protein kinase C inhibitor, on the way.
Topics: Animals; Cyclosporine; Graft Survival; Humans; Kidney Transplantation; Pyrroles; Quinazolines | 2012 |
Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts.
Topics: Animals; Cyclosporine; Drug Synergism; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Activation; Macaca fascicularis; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; T-Lymphocytes; Time Factors; Transplantation, Homologous | 2012 |
PKCθ: a new target for selective immunosuppression.
Topics: Animals; Graft Rejection; Graft vs Host Disease; Humans; Immunosuppression Therapy; Isoenzymes; Mice; Mice, Knockout; Molecular Targeted Therapy; NF-kappa B; Protein Kinase C; Protein Kinase C-theta; Protein Kinase Inhibitors; Psoriasis; Pyrroles; Quinazolines; Signal Transduction; T-Lymphocytes | 2012 |
Validation of a liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of Sotrastaurin and its metabolite N-desmethyl-sotrastaurin in human blood.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Least-Squares Analysis; Pyrroles; Quinazolines; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; G1 Phase Cell Cycle Checkpoints; Gene Expression; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Isoenzymes; MAP Kinase Signaling System; Melanoma; NF-kappa B; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Pyrroles; Quinazolines; Uveal Neoplasms | 2012 |
Effects of sotrastaurin, mycophenolic acid and everolimus on human B-lymphocyte function and activation.
Topics: Apoptosis; B-Lymphocytes; B7-1 Antigen; B7-2 Antigen; Cell Membrane; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Everolimus; Graft Rejection; Humans; Immunity, Humoral; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunosuppressive Agents; Interleukin-10; Leukocytes, Mononuclear; Mycophenolic Acid; Pyrroles; Quinazolines; Sirolimus; Transplantation, Homologous | 2012 |
Protein kinase C inhibition ameliorates posttransplantation preservation injury in rat renal transplants.
Topics: Adenosine; Allopurinol; Animals; Apoptosis; Biomarkers; Blotting, Western; Cell Proliferation; Cold Temperature; Creatinine; Cytokines; Cytoprotection; Delayed Graft Function; Glutathione; Immunohistochemistry; Inflammation Mediators; Insulin; Kidney; Kidney Transplantation; Male; Mycophenolic Acid; Organ Preservation; Organ Preservation Solutions; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Raffinose; Rats; Rats, Inbred Lew; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Signal Transduction; Time Factors | 2012 |
Combined standard and novel immunosuppressive substances affect B-lymphocyte function.
Topics: Apoptosis; B-Lymphocytes; B7-1 Antigen; Cell Proliferation; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Everolimus; Humans; Immunity, Humoral; Immunoglobulin G; Immunosuppression Therapy; Immunosuppressive Agents; Lymphocyte Activation; Mycophenolic Acid; Primary Cell Culture; Pyrroles; Quinazolines; Sirolimus | 2013 |
Tacrolimus inhibits NF-κB activation in peripheral human T cells.
Topics: Calcineurin Inhibitors; Cells, Cultured; Cytokines; Humans; Immunosuppressive Agents; NF-kappa B; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Pyrroles; Quinazolines; Signal Transduction; T-Lymphocytes; Tacrolimus | 2013 |
Association of BK viremia with human leukocyte antigen mismatches and acute rejection, but not with type of calcineurin inhibitor.
Topics: Adult; Aged; Allografts; Antibodies, Monoclonal; Azathioprine; Basiliximab; BK Virus; Cohort Studies; Cyclosporine; Female; Glomerular Filtration Rate; Graft Rejection; Histocompatibility; HLA Antigens; Humans; Immunosuppressive Agents; Kidney Diseases; Kidney Transplantation; Logistic Models; Male; Middle Aged; Multivariate Analysis; Mycophenolic Acid; Polyomavirus Infections; Proteinuria; Pyrroles; Quinazolines; Recombinant Fusion Proteins; Tacrolimus; Tumor Virus Infections; Viremia | 2014 |
Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Female; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Inhibitory Concentration 50; MAP Kinase Kinase Kinases; Melanoma; Mice; Mice, Inbred C57BL; Mice, Nude; Mutation, Missense; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Signal Transduction; Tumor Burden; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Targeting PKC in human T cells using sotrastaurin (AEB071) preserves regulatory T cells and prevents IL-17 production.
Topics: Biopsy; CD28 Antigens; Cell Proliferation; Coculture Techniques; Cytokines; Forkhead Transcription Factors; Homeostasis; Humans; Interferon-gamma; Interleukin-17; Interleukin-1beta; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation; Protein Kinase C; Psoriasis; Pyrroles; Quinazolines; Skin; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory | 2014 |
Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Topics: Adenine; Baculoviral IAP Repeat-Containing 3 Protein; Base Sequence; Blotting, Western; CARD Signaling Adaptor Proteins; Cell Line; Cell Survival; DNA Primers; Guanylate Cyclase; Humans; Inhibitor of Apoptosis Proteins; Luminescent Measurements; Lymphoma, Mantle-Cell; Microarray Analysis; Molecular Sequence Data; NF-kappa B; NF-kappaB-Inducing Kinase; Piperidines; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Pyrroles; Quinazolines; Real-Time Polymerase Chain Reaction; Receptors, Antigen, B-Cell; RNA Interference; Sequence Analysis, RNA; Signal Transduction; TNF Receptor-Associated Factor 2; TNF Receptor-Associated Factor 3; Trypan Blue; Ubiquitin-Protein Ligases | 2014 |
The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Silencing; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Melanoma; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Quinazolines; RNA Interference; Signal Transduction; Thiazoles; Tumor Burden; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2014 |
PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.
Topics: Apoptosis; beta Catenin; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Protein Kinase C beta; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Microenvironment; Wnt Signaling Pathway | 2014 |
Docetaxel Facilitates Endothelial Dysfunction through Oxidative Stress via Modulation of Protein Kinase C Beta: The Protective Effects of Sotrastaurin.
Topics: Antineoplastic Agents, Phytogenic; Docetaxel; Endothelium, Vascular; Glutathione; Human Umbilical Vein Endothelial Cells; Humans; Oxidative Stress; Protein Kinase C beta; Pyrroles; Quinazolines; Reactive Oxygen Species; Taxoids | 2015 |
Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Cell Proliferation; Cells, Cultured; DNA, Ribosomal; Gene Expression; Guanosine Triphosphate; HEK293 Cells; Humans; Jurkat Cells; Keratin-20; Lymphocyte Activation; Mutation; Mycophenolic Acid; Phosphorylation; Pol1 Transcription Initiation Complex Proteins; Proliferating Cell Nuclear Antigen; Promoter Regions, Genetic; Protein Binding; Protein Kinase C-delta; Pyrroles; Quinazolines; RNA Interference; RNA Polymerase I; RNA-Binding Proteins; RNA, Ribosomal; T-Lymphocytes | 2015 |
The Selective Estrogen Receptor Modulator Raloxifene Regulates Arginine-Vasopressin Gene Expression in Human Female Neuroblastoma Cells Through G Protein-Coupled Estrogen Receptor and ERK Signaling.
Topics: Arginine Vasopressin; Blotting, Western; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Neuroblastoma; Phosphorylation; Protein Kinase C; Pyrroles; Quinazolines; Raloxifene Hydrochloride; Receptors, Estrogen; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Selective Estrogen Receptor Modulators | 2015 |
Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC‑α/ERK1/2 pathway: An in vitro investigation.
Topics: Antineoplastic Agents; Apoptosis; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Flavonoids; Humans; Integrin beta1; Isoflavones; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phorbol Esters; Protein Kinase C-alpha; Pyrroles; Quinazolines; Signal Transduction | 2015 |
Targeting protein kinase C in mantle cell lymphoma.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; Cell Death; Drug Resistance, Neoplasm; Humans; Lymphoma, Mantle-Cell; MAP Kinase Signaling System; Molecular Targeted Therapy; Phosphorylation; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrroles; Quinazolines; Tumor Cells, Cultured | 2016 |
Efficacy and Safety of Elective Conversion From Sotrastaurin (STN) to Tacrolimus (TAC) or Mycophenolate (MPS) in Stable Kidney Transplant Recipients.
Topics: Adult; Antibodies; Cohort Studies; Drug Interactions; Drug Substitution; Everolimus; Female; Glomerular Filtration Rate; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Prednisone; Prospective Studies; Pyrroles; Quinazolines; Tacrolimus | 2016 |
Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; DNA; Dose-Response Relationship, Drug; Extracellular Traps; Glucose; Humans; Hypoglycemic Agents; Middle Aged; Neutrophils; Peroxidase; Polymers; Pyrazines; Pyrroles; Quinazolines; Risk Factors; Spiro Compounds; Time Factors | 2016 |
Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Enzyme Inhibitors; Everolimus; Humans; Isoquinolines; Mechanistic Target of Rapamycin Complex 1; Melanoma; Mice; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-mdm2; Pyrroles; Quinazolines; Tumor Suppressor Protein p53; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism.
Topics: Acetylation; Animals; Antiviral Agents; Bryostatins; Carbazoles; Cell Line; Chikungunya virus; Chlorocebus aethiops; Drug Design; Drug Synergism; Gene Expression Regulation, Viral; Humans; Isoenzymes; Kinetics; Methylation; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Semliki forest virus; Sindbis Virus; Viral Proteins; Virus Replication | 2016 |
Inhibition of JAK3 and PKC via Immunosuppressive Drugs Tofacitinib and Sotrastaurin Inhibits Proliferation of Human B Lymphocytes In Vitro.
Topics: Apoptosis; B-Lymphocytes; CD40 Ligand; Cell Proliferation; Cells, Cultured; Humans; Immunosuppressive Agents; Interleukin-10; Interleukin-2; Interleukins; Janus Kinase 3; Leukocytes, Mononuclear; Lymphocyte Activation; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Sirolimus | 2016 |
Protein kinases C as potential host targets for the inhibition of chikungunya virus replication.
Topics: Acetophenones; Animals; Benzopyrans; Chikungunya Fever; Chikungunya virus; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Enzyme Inhibitors; Fibroblasts; Humans; Phorbol Esters; Protein Kinase C; Pyrroles; Quinazolines; Skin; Vero Cells; Virus Replication | 2017 |
PKC inhibition of sotrastaurin has antitumor activity in diffuse large B-cell lymphoma via regulating the expression of MCT-1.
Topics: Animals; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Gene Silencing; Humans; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Oncogene Proteins; Protein Kinase C; Pyrroles; Quinazolines; RNA, Messenger; RNA, Small Interfering; Signal Transduction | 2018 |
Protein kinase Cδ (PKCδ) involved in the regulation of pAkt1 (Ser473) on the release of mouse oocytes from diplotene arrest.
Topics: Animals; Dose-Response Relationship, Drug; Down-Regulation; Mice; Mice, Inbred Strains; Oocytes; Phosphorylation; Protein Kinase C-delta; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Structure-Activity Relationship | 2018 |
Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Leukemia, Myeloid, Acute; Phosphorylation; Protein Isoforms; Protein Kinase C-alpha; Proto-Oncogene Proteins c-pim-1; Pyrroles; Quinazolines; Serine | 2018 |
Sotrastaurin attenuates the stemness of gastric cancer cells by targeting PKCδ.
Topics: Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Humans; Neoplasm Metastasis; Neoplastic Stem Cells; Protein Kinase C-delta; Pyrroles; Quinazolines; Stomach Neoplasms | 2019 |
Effect of miR-196a inhibition on esophageal cancer growth in vitro.
Topics: Apoptosis; Biomarkers, Tumor; Cell Proliferation; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; MicroRNAs; Protein Kinase C; Pyrroles; Quinazolines; Tumor Cells, Cultured | 2020 |
Morphine induces the differentiation of T helper cells to Th2 effector cells via the PKC-θ-GATA3 pathway.
Topics: Analgesics, Opioid; Animals; Cell Differentiation; GATA3 Transcription Factor; Interferon-gamma; Interleukin-4; Male; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Protein Kinase C-theta; Pyrroles; Quinazolines; T-Lymphocytes, Helper-Inducer | 2020 |
Sotrastaurin, a PKC inhibitor, attenuates RANKL-induced bone resorption and attenuates osteochondral pathologies associated with the development of OA.
Topics: Animals; Bone and Bones; Bone Resorption; Cartilage Diseases; Cartilage, Articular; Cattle; Cell Differentiation; Female; Male; Mice; Mice, Inbred C57BL; Osteoarthritis; Osteoclasts; Protein Kinase C; Pyrroles; Quinazolines; RANK Ligand; Signal Transduction | 2020 |
AEB-071 Ameliorates Muscle Weakness by Altering Helper T Lymphocytes in an Experimental Autoimmune Myasthenia Gravis Rat Model.
Topics: Animals; Female; Lymphocyte Activation; Muscle Weakness; Myasthenia Gravis, Autoimmune, Experimental; Pyrroles; Quinazolines; Rats; Rats, Inbred Lew; T-Lymphocytes, Helper-Inducer | 2020 |
Protein kinase C targeting of luminal (T-47D), luminal/HER2-positive (BT474), and triple negative (HCC1806) breast cancer cells in-vitro with AEB071 (Sotrastaurin) is efficient but mediated by subtype specific molecular effects.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Protein Kinase C; Pyrroles; Quinazolines; Receptor, ErbB-2 | 2022 |