Page last updated: 2024-08-21

quinazolines and sch 529074

quinazolines has been researched along with sch 529074 in 2 studies

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	1 (50.00)	2.80

Authors

Authors	Studies
Bishop, WR; Dasmahapatra, B; Demma, M; Doll, R; Hesk, D; Li, C; Liang, L; Liu, M; Mallams, A; Maxwell, E; Ramos, R; Rossman, R; Seidel-Dugan, C	1
Chen, Y; Haase, D; Li, Y; Lu, G; Ma, Y; Nenkov, M; Petersen, I; Zhou, Z	1

Other Studies

2 other study(ies) available for quinazolines and sch 529074

Article	Year
SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. The Journal of biological chemistry, 2010, Apr-02, Volume: 285, Issue:14 Topics: Animals; Apoptosis; Binding Sites; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; Colorectal Neoplasms; DNA; Female; Humans; Immunoprecipitation; Mice; Mice, Nude; Molecular Chaperones; Mutation; Piperazines; Protein Binding; Proto-Oncogene Proteins c-mdm2; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Protein p53; Ubiquitination; Xenograft Model Antitumor Assays	2010
Growth inhibitory role of the p53 activator SCH 529074 in non‑small cell lung cancer cells expressing mutant p53. Oncology reports, 2020, Volume: 43, Issue:6 Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lung Neoplasms; Mutation; Piperazines; Quinazolines; Signal Transduction; Tumor Suppressor Protein p53	2020

Article

Year

SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53.

The Journal of biological chemistry, 2010, Apr-02, Volume: 285, Issue:14

Topics: Animals; Apoptosis; Binding Sites; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; Colorectal Neoplasms; DNA; Female; Humans; Immunoprecipitation; Mice; Mice, Nude; Molecular Chaperones; Mutation; Piperazines; Protein Binding; Proto-Oncogene Proteins c-mdm2; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Protein p53; Ubiquitination; Xenograft Model Antitumor Assays

2010

Growth inhibitory role of the p53 activator SCH 529074 in non‑small cell lung cancer cells expressing mutant p53.

Oncology reports, 2020, Volume: 43, Issue:6

Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lung Neoplasms; Mutation; Piperazines; Quinazolines; Signal Transduction; Tumor Suppressor Protein p53

2020