quinazolines has been researched along with rutecarpine in 190 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.05) | 18.7374 |
| 1990's | 12 (6.32) | 18.2507 |
| 2000's | 69 (36.32) | 29.6817 |
| 2010's | 83 (43.68) | 24.3611 |
| 2020's | 24 (12.63) | 2.80 |
| Authors | Studies |
|---|---|
| Agurell, E; Cederberg, H; Rannug, A; Rannug, U | 1 |
| Kano, Y; Komatsu, K; Qine, Z | 1 |
| Bergman, J; Cambillau, C; Gillner, M; Gustafsson, JA | 1 |
| Chen, CF; Chou, CJ; Hsu, SY; Ko, HC; Li, SY; Tsai, TH | 1 |
| Chen, CF; Chiou, WF; Chou, CJ; Liao, JF; Sham, AY | 1 |
| Chen, CF; Chiou, WF; Liao, JF | 1 |
| Momma, N; Ohsawa, K; Ueda, J; Yamauchi, Y; Yoshie, F | 1 |
| Chen, CF; Chou, CJ; Pang, PK; Shan, J; Wang, GJ; Yang, MC | 1 |
| Hung, WC; Lee, YM; Sheu, JR; Yen, MH | 1 |
| Iinuma, M; Kubo, M; Matsuda, H; Tanaka, T; Wu, JX | 1 |
| Chen, CF; Chiou, WF; Liao, JF; Shum, AY | 1 |
| Chen, CF; Huang, YT; Lin, LC; Pang, PK; Shan, J; Wang, GJ; Wu, XC | 1 |
| Chang, HW; Kang, SS; Kim, HP; Kudo, I; Moon, TC; Murakami, M; Son, KH | 1 |
| Chiu, JH; Jiang, JK; Lin, JK; Yu, IT | 1 |
| Hung, WC; Lee, YM; Sheu, JR; Wu, CH; Yen, MH | 1 |
| Hoshikuma, K; Kamiya, T; Kobayashi, Y; Nakano, Y; Yokoo, Y | 1 |
| Baik, EJ; Jung, YS; Lee, CH; Lee, JJ; Lee, SH; Moon, CH; Noh, MS; Woo, HG | 1 |
| Chen, H; Chiang, HT; Li, HF; Lo, YK; Wu, SN | 1 |
| Chen, CF; Lin, LC; Park, SS; Ueng, YF; Wang, JJ | 1 |
| Chen, CF; Chen, TL; Guengerich, FP; Jan, WC; Lin, LC; Ueng, YF | 1 |
| Chen, CF; Chen, KT; Ko, HC; Ueng, YF; Wang, JJ | 1 |
| Deng, HW; Hu, CP; Li, YJ; Xiao, L | 2 |
| Fei, XF; Ikejima, T; Li, TJ; Minami, M; Tashiro, S; Wang, BX; Xing, DJ | 1 |
| Deng, HW; Hu, CP; Li, NS; Li, YJ; Xiao, L | 1 |
| Wang, YL; Wei, LX; Xu, YC; Zhou, YX | 1 |
| Don, MJ; Lewis, DF; Tsai, MW; Ueng, YF; Wang, SY | 1 |
| Jahng, Y; Jeong, TC; Kim, DH; Lee, ES; Lee, J; Lee, SK | 1 |
| Cai, WJ; Deng, HW; Deng, PY; Hu, CP; Li, YJ; Tan, GS; Ye, F | 1 |
| Chang, HW; Choi, HG; Jahng, Y; Jeong, TC; Kim, DH; Kim, NH; Lee, ES; Lee, J; Lee, SK | 1 |
| Beak, SM; Jahng, Y; Kim, JA; Lee, YS; Paek, SH | 1 |
| Liang, JY; Wang, QZ | 1 |
| Deng, PY; Hu, CP; Li, YJ; Tan, GS; Xu, KP; Yu, J | 1 |
| Deng, PY; Hu, CP; Li, YJ; Liu, GZ; Rang, WQ; Tan, GS; Xu, KP; Yi, HH | 1 |
| Aggarwal, BB; Kobayashi, Y; Takada, Y | 1 |
| Chen, RM; Chen, TL; Don, MJ; Tsai, TH; Ueng, YF | 1 |
| Decker, M | 1 |
| Hiratsuka, A; Iwata, H; Kadota, S; Tezuka, Y; Watabe, T | 1 |
| Deng, PY; Ding, JS; Hu, CP; Li, YJ; Shen, SS; Tan, GS; Wang, L; Zhu, HQ | 1 |
| Chen, CF; Don, MJ; Ho, LK; Jan, WC; Lee, CH; Peng, C; Ueng, YF; Yu, HJ | 1 |
| Chang, CH; Lin, LC; Tsai, TH | 1 |
| Choi, HG; Jahng, Y; Kim, JK; Kim, JO; Park, BJ; Park, YJ; Rhee, JD; Yong, CS; Yoo, BK | 1 |
| Jahng, Y; Jeong, TC; Kim, DH; Lee, JH; Lee, SK; Yoo, HH | 1 |
| Jahng, Y; Jeon, TW; Jeong, HG; Jeong, TC; Jin, CH; Jun, IH; Kim, GH; Lee, DJ; Lee, KB; Lee, SK | 1 |
| Jahng, Y; Jeon, TW; Jeong, TC; Jin, CH; Jun, IH; Kim, DH; Kim, GH; Kim, SI; Lee, DJ; Lee, DW; Lee, SK | 1 |
| Brown, DA; Canning, MT; Galvin, JW; Nay, SL; Peña, AV; Yarosh, DB | 1 |
| Chen, CF; Don, MJ; Ho, LK; Jan, WC; Ueng, YF; Wang, SY | 1 |
| Benvenuti, S; Melegari, M; Pellati, F; Yoshizaki, F | 1 |
| Cai, XF; Choi, YH; Kim, HP; Kim, YS; Lee, JJ; Shin, EM | 1 |
| Li, C; Liao, Y; Liu, H; Liu, Y; Wen, D | 1 |
| Chen, CF; Don, MJ; Jan, WC; Lin, LC; Tsai, TH | 1 |
| Chen, CF; Chen, CM; Chen, KT; Ko, HC; Su, JP; Wang, GJ | 1 |
| Chang, S; Chen, CF; Chen, CH; Chen, CM; Chen, KT; Hou, YC; Ko, HC; Liou, KT; Shen, YC; Wang, WY; Wang, YH | 1 |
| Bowman, WR; Elsegood, MR; Stein, T; Weaver, GW | 1 |
| Bae, EA; Cai, XF; Kim, DH; Lee, JJ; Shin, YW | 1 |
| Bhamdari, K; Choi, HG; Jahng, Y; Kim, DH; Lee, MH; Park, BJ; Woo, JS; Yong, CS; Yoo, BK | 1 |
| Gao, HM; Hong, YM; Wang, JY; Wang, WH; Wang, ZM | 1 |
| Chen, QQ; Deng, HW; Hu, GY; Li, D; Li, YJ; Luo, D; Qin, XP; Zeng, SY; Zhang, Z | 1 |
| Hu, Z; Wu, D | 1 |
| Cai, GX; Huang, D; Li, SX; Wei, LJ; Yue, CH; Zhang, P | 1 |
| Bista, SR; Jahng, Y; Jeong, H; Jeong, TC; Kang, MJ; Kim, DH; Lee, SK | 1 |
| Chang, HW; Jahng, Y; Jeong, BS; Jeong, TC; Lee, ES; Lee, SH; Son, JK | 1 |
| Jahng, KC; Jahng, Y; Kim, DH; Kim, SI; Lee, ES; Lee, SH; Seo, CS; Son, JK | 1 |
| Deng, HW; Jiang, DJ; Li, D; Li, YJ; Luo, D; Peng, J; Xin, HY; Zhang, YS; Zhou, Z | 1 |
| Teng, J; Wang, Y; Xu, W; Yang, XW | 1 |
| Ahn, H; Mar, W; Nam, JW; Seo, EK | 1 |
| Cui, L; Dai, Z; Hu, GY; Jiang, DJ; Liu, SY; Xiao, J | 1 |
| Hu, GY; Li, D; Li, YJ; Liu, YZ; Peng, J; Wang, L; Zhou, Y | 1 |
| Cai, Z; Gong, X; Li, Z; Zhao, Y; Zhou, C; Zhou, X | 1 |
| Ding, JS; Gao, R; Li, D; Li, YJ; Peng, J; Ran, LL | 1 |
| Chen, SY; Deng, SX; Li, D; Li, YJ; Liao, DF; Qin, XP; Ren, JF; Tian, HH; Zeng, SY; Zheng, YB | 1 |
| Chen, L; Deng, HW; Li, D; Li, YJ; Peng, J; Yang, Z; Zhang, XJ | 1 |
| Heo, SK; Noh, EK; Park, SD; Yi, HS; Yun, HJ | 1 |
| Cazal, Cde M; da Silva, MF; Fernandes, JB; Forim, MR; Rodrigues-Filho, E; Severino, VG; Vieira, PC | 1 |
| Chen, J; Chen, Z; Hu, G; Li, D; Li, Y; Xie, Y; Zhou, H | 1 |
| Guo, H; Kraus, GA | 1 |
| Chao, HL; Wang, PS; Wang, SW; Yu, PL | 1 |
| Du, M; Jin, R; Kang, C; Li, J; Li, M; Liu, S | 1 |
| Chae, S; Han, MD; Kim, SJ; Lee, S; Lee, SJ; Mar, W; Nam, KW | 1 |
| Han, EH; Im, JH; Jeong, HG; Jeong, TC; Kim, HG | 1 |
| An, LK; Gu, LQ; Hou, JQ; Huang, SL; Huang, ZS; Li, D; Li, Y; Mai, YC; Ou, TM; Tan, JH; Wang, B | 1 |
| Feng, W; Gao, H; Gong, M; Song, Y; Wang, W; Wang, Z; Yan, L; Zhang, Q; Zhu, J | 1 |
| Kang, C; Li, M; Liu, S; Tong, H; Wang, Y; Yin, W; Zhou, Z | 1 |
| Hu, C; Jia, S | 1 |
| Chen, XP; Hu, CP; Li, D; Li, TT; Li, YJ; Peng, J; Wang, CJ; Zhou, Z | 1 |
| Abel, J; Bothe, H; Fritsche, E; Götz, C; Haarmann-Stemmann, T; Krug, N; Proksch, P; Sendker, J | 1 |
| Chen, MC; Chi, CW; Ho, LL; Kan, SF; Lee, CH; Lin, LC; Pu, HF; Wang, PS; Wang, SW; Yu, CH | 1 |
| Chen, JJ; Hwang, TL; Kuo, YH; Wang, TY; Wu, JB | 1 |
| An, LK; Chu, WY; Gu, LQ; Hou, JQ; Huang, SL; Huang, ZS; Li, D; Li, Z; Ou, TM; Tan, JH; Wang, B | 1 |
| Hong, YH; Jahng, Y; Kim, HL; Kwon, Y; Lee, SH; Lee, WJ; Nam, JM; Son, JK | 1 |
| Deng, HW; Hu, CP; Li, JZ; Li, XH; Li, YJ; Liao, MC; Peng, J; Xiao, L; Zhang, YS | 1 |
| Chang, Y; Guo, F; Jiang, H; Liu, B; Wang, Q | 1 |
| Bao, MH; Dai, W; Hu, CP; Li, YJ | 1 |
| Bista, SR; Jahng, Y; Jeong, TC; Kang, MJ; Kang, W; Kim, E; Lee, SK; Noh, K; Seo, YM | 1 |
| Guo, YN; Tong, M; Zhang, GY | 1 |
| Chen, Y; Huang, Z; Liu, Y; Wu, Y; Yi, J | 1 |
| Li, J; Liu, Y; Ma, X | 1 |
| Cheng, HT; Chu, YH; Shen, MJ; Tseng, MC | 1 |
| Feng, NP; Liu, Y; Shi, F; Wang, Z; Zhang, SJ; Zhang, YT; Zhao, JH; Zhong, YZ | 1 |
| Chen, F; Ding, J; He, L; Li, Y; Peng, J; Xu, S; Zhang, J | 1 |
| Cai, J; Li, W; Lin, C; Lin, G; Ma, J; Pan, J; Pan, X; Wang, X | 1 |
| Bubenyák, M | 1 |
| Bao, T; Dong, Y; Li, Y; Weng, X; Yang, Q; Zhang, Y; Zhu, X | 1 |
| Hu, CQ; Li, F; Yang, XW | 1 |
| An, LK; Gu, LQ; Hou, JQ; Huang, SL; Huang, ZS; Li, D; Li, Z; Ou, TM; Tan, JH; Wang, B | 1 |
| Chen, F; Ding, JS; Li, D; Li, S | 1 |
| Hu, CQ; Li, KK; Yang, XW | 1 |
| Jahng, Y; Kim, SI; Lee, CS; Lee, ES; Lee, SH | 1 |
| Feng, NP; Huang, ZB; Liu, Y; Wang, Z; Zhang, SJ; Zhang, YT; Zhao, JH | 1 |
| Chen, Y; Huang, Z; Liu, Y; Tang, X; Yi, J; Zhao, J | 1 |
| Chen, SB; Gu, LQ; He, Y; Huang, SL; Huang, ZH; Huang, ZS; Li, D; Tan, JH; Yao, PF | 1 |
| Jin, T; Liu, J; Lu, YF; Wu, Q; Zhang, D; Zhu, QN | 1 |
| Borralho, PM; Ferreira, MJ; Luo, X; Mansoor, TA; Mulhovo, S; Rodrigues, CM | 1 |
| Gong, QH; Li, YJ; Sun, AS; Wu, Q; Yu, LM; Zhang, F | 1 |
| Chen, JW; Chen, YC; Gu, LQ; He, Y; Huang, ZS; Liu, H; Liu, PQ; Wang, B; Ye, JM; Zeng, XY; Zhou, H | 1 |
| Gu, JA; Huang, SH; Huang, ST; Lee, CM; Lin, CM; Lin, FY; Rau, TG; Yang, CH; Yang, WC | 1 |
| Ivanova, B; Spiteller, M | 1 |
| Jin, HW; Qian, P; Yang, XW | 1 |
| Liu, L; Moore, DJ; Roongta, V; Wen, B | 1 |
| Feng, T; He, X; Hong, B; Jiang, JD; Lai, F; Li, N; Li, Y; Liu, C; Liu, J; Liu, Q; Si, S; Wang, X; Wu, Y; Xu, Y; Zhang, M; Zhu, N | 1 |
| Fu, Q; Jin, Y; Li, K; Li, Z; Liang, T | 1 |
| Domonkos, C; Fitos, I; Visy, J; Zsila, F | 1 |
| Bian, K; Nie, XQ; Shi, HX; Yang, JW; Yuan, Y; Zhang, JY; Zhang, YJ | 1 |
| Cai, Q; Li, W; Shi, S; Wang, Q; Wei, J; Wei, R; Zhang, Y; Zhao, W | 1 |
| Missler, SR; Rebhun, JF; Roloff, SJ; Velliquette, RA | 1 |
| Li, S; Li, XW; Wang, XM; Yang, JR | 1 |
| Fu, YQ; He, M; Huang, QR; Kuang, HB; Liu, Y; Luo, D; Peng, WJ; Yu, YR; Zhao, Y | 1 |
| Gong, M; Li, J; Li, Z; Lu, X; Pan, X; Shang, Y; Wang, M; Wu, Y; Xu, Y; Zhai, Y | 1 |
| Dandpat, SS; Sarkar, M | 1 |
| An, LJ; He, LN; He, X; Wang, LL; Yang, AH; Zhai, YR; Zhang, FL; Zhang, SC | 1 |
| Chang, HW; Jahng, Y; Son, JK | 1 |
| Cheng, Y; Li, X; Wang, X; Xue, H; Yue, Y; Zhang, W | 1 |
| Chen, B; Hu, H; Huang, M; Lei, J; Li, Y; Lu, J; Wang, Z; Xie, W; Yu, L; Zeng, K; Zeng, S | 1 |
| Gao, L; Gu, LQ; Huang, SL; Huang, ZS; Li, D; Liu, H; Ou, TM; Rao, Y; Tan, JH; Wang, HG; Ye, JM; Yu, H | 1 |
| Gong, M; He, R; He, S; Lu, X; Pan, X; Wu, Y; Xu, Y | 1 |
| Fu, YQ; He, M; Huang, QR; Liu, Y; Luo, D; Peng, WJ; Wu, YS; Yan, H; Yu, YR | 1 |
| Bian, K; Chen, HH; He, YQ; Murad, F; Nie, XQ; Pan, HJ; Song, WX; Yang, JW; Zhang, JY; Zhang, YJ | 1 |
| Du, J; Li, D; Li, WQ; Li, XH; Li, YJ; Xiong, XM; Zhang, W | 1 |
| Dai, Y; Kogure, Y; Noguchi, K; Wang, S; Yamamoto, S; Zhang, W | 1 |
| Walton, JC | 1 |
| Gao, B; Guo, H; Liu, D; Ren, H; Santos, HA; Xu, F; You, M; Zhang, H; Zhang, X | 1 |
| Cai, W; Guan, Y; Ji, H; Liu, Z; Wang, Y; Zhou, Y | 1 |
| Choi, CY; Chung, YC; Hwang, YP; Jeong, HG; Jeong, TC; Jin, SW; Kim, HG; Kim, SJ; Kim, Y; Lee, KJ | 1 |
| Gu, JA; Huang, SH; Huang, ST; Lee, CM; Lin, CM; Lin, FY; Rau, TG; Wang, C; Yen, CH | 1 |
| Hao, Z; Liang, C; Sun, Y; Wang, C; Zhang, L; Zhou, J | 1 |
| Feng, NP; He, ZH; Li, Z; Xia, Q; Zhang, HY; Zhang, K; Zhang, YT; Zhao, JH | 1 |
| Jahng, Y; Jeong, TC; Kang, MJ; Kang, Y; Kim, JA; Kim, JH; Lee, DW; Lee, S; Lee, YJ; Nepal, MR; Noh, K; Shakya, R | 1 |
| Chen, XP; Hou, HH; Lin, SX; Sun, AS; Xu, Y; Zhang, F; Zhang, JY | 1 |
| Decker, M; Drakopoulos, A; Heilmann, J; Huang, G; Meinel, L; Saedtler, M; Zou, H | 1 |
| Chen, Q; He, L; Jia, S; Li, D; Li, X; Li, Y; Wang, A; Yang, Y | 1 |
| Cai, Y; Deng, J; Qin, J; Yu, S; Zhang, X; Zhong, X | 1 |
| Fukuma, Y; Komaki, S; Nishishita, K; Okamoto, K; Sakai, E; Tsukuba, T | 1 |
| Bisson, WH; Gonzalez, FJ; Krausz, KW; Sun, D; Xie, C; Yagai, T; Yan, T; Yang, X; Zhang, L; Zhang, Y; Zheng, Y | 1 |
| Ji, L; Li, Z; Wu, M | 1 |
| Gao, YX; Jiang, LL; Li, XW; Zhang, Q; Zuo, DZ | 1 |
| Chen, M; Li, Y; Tang, F; Tong, M; Wen, H; Xiao, R; Zhang, G; Zhao, M | 1 |
| Aisa, HA; Cao, JG; Huang, GZ; Liu, FZ; Nie, LF; Wang, SS; Xiamuxi, H | 1 |
| Li, JJ; Tian, KM; Xu, SW | 1 |
| Cao, W; Chen, L; Deng, X; Fan, J; Li, Y; Ma, J; Wang, Y; Zeng, G; Zhou, Y | 1 |
| Fu, Y; Li, T; Luo, D; Peng, W; Wang, M; Wang, X; Wu, Y; Yan, H; Yu, Y | 1 |
| Bhattacharjee, A; Biswas, K; Chatterjee, A; Gurung, AB; Joshi, SR; Pamay, P; Tripathy, D | 1 |
| Gao, L; Lu, HQ; Qin, XP; Yan, QJ; Yang, L; Zeng, SY | 1 |
| Chen, Z; Liu, Y; Mao, Z; Zhou, W | 1 |
| Chen, JG; Li, X; Wu, YG | 1 |
| Chen, Z; Zhang, B | 1 |
| Chen, Y; Han, M; Hu, L | 1 |
| Gonzalez, FJ; Krausz, KW; Liu, X; Luo, Y; Sun, D; Wang, J; Wang, P; Wang, Q; Wang, T; Xie, C; Yagai, T; Yan, T; Yang, X; Zhang, Y | 1 |
| Han, X; Jiang, X; Li, N; Li, Y; Liu, C; Luo, J; Si, S; Wang, X; Xu, Y; Zuo, X | 1 |
| Ge, J; Li, X; Liu, R; Sun, R; Zhang, J; Zheng, Q | 1 |
| Dong, YH; Huang, XF; Ke, HM; Song, GQ; Wang, JH; Xu, DF | 1 |
| Devi, RV; Singh, CB; Singh, OJ; Surbala, L | 1 |
| Cai, YT; Dong, YH; Jiang, L; Jin, J; Li, J; Li, Z; Liu, MM; Liu, XQ; Ma, TT; Meng, XM; Wang, JN; Wen, JG; Wu, MF; Wu, YG | 1 |
| An, XW; Chen, C; Chen, F; Hu, N; Jia, XL; Li, XH; Liu, R; Sun, HT; Wang, JJ; Wang, Y; Zhao, B; Zheng, CG | 1 |
| Li, WQ; Li, YJ; Ma, WJ; Yin, YC; Zhang, BK | 1 |
| Chu, Y; Gu, P; Hui, X; Lin, S; Liu, X; Loomes, K; Mao, L; Nie, T; Tang, S; Wu, D; Xu, Y; Zhang, Y; Zhao, S; Zhao, X | 1 |
| Du, XS; Huang, C; Li, HD; Li, J; Li, JJ; Li, Z; Meng, XM; Wu, MF; Xu, JJ; Zhu, L | 1 |
| Chen, X; Jing, M; Li, H; Li, R; Niu, M; Ren, S; Tong, Y; Wang, D; Wang, M; Wang, R; Wei, S; Wei, Y; Wen, J; Wu, S; Yang, T; Zhao, Y | 1 |
| Lin, JY; Yeh, TH | 1 |
| Cui, WF; Ge, WJ; Li, BJ; Li, GS; Liang, RF; Song, XM; Zhang, SF; Zhang, YY | 1 |
| Chen, P; Jia, J; Jia, Y; Li, H; Wang, X; Wang, Y; Xiu, R; Xue, Y; Zhang, G; Zhang, X; Zhao, Z | 1 |
| Ding, J; Guo, Z; Huang, H; Jia, Y; Liu, H; Peng, J; Wang, H; Wang, M; Wu, D | 1 |
| Bhavan, PS; Chang, CC; Hsia, CW; Hsieh, CY; Huang, CJ; Huang, WC; Jayakumar, T; Lin, WT; Sheu, JR; Shu, LH; Tran, OT | 1 |
| Chu, QR; Du, SS; He, YH; Li, HX; Liu, YQ; Tang, C; Wang, JR; Wu, TL; Yang, CJ; Zhang, ZJ | 1 |
| Guo, SW; Luo, D; Peng, WJ; Wang, HX; Xiong, Y; Yan, H; Zhu, SL | 1 |
| Chang, CC; Hsia, CH; Hsia, CW; Huang, WC; Jayakumar, T; Lin, KC; Manubolu, M; Sheu, JR | 1 |
| Bhavan, PS; Chung, CL; Hou, SM; Hsia, CH; Hsia, CW; Huang, WC; Jayakumar, T; Sheu, JR; Wu, MP | 1 |
| Hsia, CH; Hsia, CW; Hsieh, CY; Hsu, CY; Huang, WC; Jayakumar, T; Manubolu, M; Sheu, JR; Yang, CM; Yen, TL | 1 |
| Guo, H; Jin, R; Liu, J; Tang, Y; Wang, Y; Yan, H; Zhou, J | 1 |
| Chang, L; Chen, LS; He, TT; He, Y; Jing, MY; Li, HT; Liu, HH; Wang, X; Wei, SZ; Zhang, AZ; Zhao, YL; Zhou, XL | 1 |
7 review(s) available for quinazolines and rutecarpine
| Article | Year |
|---|---|
Progress in the studies on rutaecarpine.
Topics: Animals; Humans; Indole Alkaloids; Quinazolines | 2008 |
Pharmacological effects of rutaecarpine as a cardiovascular protective agent.
Topics: Animals; Cardiotonic Agents; Humans; Indole Alkaloids; Quinazolines | 2010 |
Progress in Studies on Rutaecarpine. II.--Synthesis and Structure-Biological Activity Relationships.
Topics: Alkaloids; Cholinesterase Inhibitors; Cholinesterases; Evodia; Indole Alkaloids; Microsomes, Liver; Plant Extracts; Quinazolines; Structure-Activity Relationship | 2015 |
Synthetic Strategies for 5- and 6-Membered Ring Azaheterocycles Facilitated by Iminyl Radicals.
Topics: Catalysis; Cyclization; Dioxoles; Free Radicals; Indole Alkaloids; Oximes; Phenanthridines; Pyridines; Pyrroles; Quinazolines; Quinones | 2016 |
Rutaecarpine: A promising cardiovascular protective alkaloid from Evodia rutaecarpa (Wu Zhu Yu).
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Antioxidants; Cardiotonic Agents; Cardiovascular Diseases; Evodia; Humans; Hypolipidemic Agents; Indole Alkaloids; Platelet Aggregation Inhibitors; Quinazolines; Vasodilator Agents | 2019 |
Evodiamine and rutaecarpine from Tetradium ruticarpum in the treatment of liver diseases.
Topics: Animals; Evodia; Humans; Indole Alkaloids; Liver Diseases; Plants, Medicinal; Quinazolines | 2020 |
Calcitonin gene‑related peptide‑mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review).
Topics: Calcitonin Gene-Related Peptide; Cardiovascular Diseases; Gastrointestinal Diseases; Gene Expression Regulation; Humans; Indole Alkaloids; Molecular Targeted Therapy; Nitroglycerin; Quinazolines; Up-Regulation | 2021 |
1 trial(s) available for quinazolines and rutecarpine
| Article | Year |
|---|---|
Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine.
Topics: Administration, Cutaneous; Adult; Alkaloids; Anti-Inflammatory Agents; Biomimetics; Cell Line; Dinoprostone; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Erythema; Evodia; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Indole Alkaloids; Keratinocytes; Middle Aged; Nicotinic Acids; Nitric Oxide; Plant Extracts; Quinazolines; Skin; Time Factors; Ultraviolet Rays | 2006 |
182 other study(ies) available for quinazolines and rutecarpine
| Article | Year |
|---|---|
Certain tryptophan photoproducts are inhibitors of cytochrome P450-dependent mutagenicity.
Topics: Alkaloids; Animals; Antimutagenic Agents; Carbazoles; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Gene Conversion; Hypoxanthine Phosphoribosyltransferase; Indole Alkaloids; Indoles; Male; Mutagenesis; Mutagenicity Tests; Mutagens; Mutation; Oxidoreductases; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Receptors, Drug; Regression Analysis; Saccharomyces cerevisiae; Salmonella typhimurium; Sister Chromatid Exchange; Suppression, Genetic; Tryptophan; Ultraviolet Rays | 1992 |
[On the evaluation of the preparation of Chinese medicinal prescriptions. VI. The changes of the alkaloid contents by processing of Evodia fruit].
Topics: Alkaloids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Humans; Indole Alkaloids; Plant Extracts; Quinazolines; Quinolones; Taste | 1991 |
Interactions of rutaecarpine alkaloids with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver.
Topics: Alkaloids; Binding Sites; Binding, Competitive; Computer Graphics; Dioxins; Indole Alkaloids; Liver; Molecular Structure; Polychlorinated Dibenzodioxins; Quinazolines | 1989 |
High-performance liquid chromatographic determination of rutaecarpine in rat plasma: application to a pharmacokinetic study.
Topics: Acetophenones; Alkaloids; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Indole Alkaloids; Injections, Intravenous; Male; Models, Biological; Quinazolines; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet | 1994 |
The mechanism of the vasodilator effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa.
Topics: Acetylcholine; Alkaloids; Animals; Arginine; Atropine; Calcium; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Indole Alkaloids; Male; Mesenteric Arteries; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Phenylephrine; Quinazolines; Rats; Rats, Sprague-Dawley; Triprolidine; Vasodilation; Yohimbine | 1994 |
Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa.
Topics: Alkaloids; Animals; Aorta, Thoracic; Arginine; Calcium Channel Blockers; Enzyme Inhibitors; In Vitro Techniques; Indole Alkaloids; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Plant Extracts; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Vasodilator Agents | 1996 |
[A simultaneous determination of evodiamine and rutaecarpine in oriental pharmaceutical decoctions containing Evodia fruit by ion-pair high-performance liquid chromatography].
Topics: Alkaloids; Cardiotonic Agents; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Indole Alkaloids; Plant Extracts; Quinazolines | 1996 |
The vasorelaxing action of rutaecarpine: direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells.
Topics: Alkaloids; Animals; Blood Pressure; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium; Indole Alkaloids; Male; Muscle, Smooth, Vascular; Quinazolines; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 1996 |
Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa.
Topics: Alkaloids; Blood Platelets; Cyclic AMP; Cyclic GMP; Humans; Indole Alkaloids; Nitric Oxide; Phosphatidylinositols; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinazolines; Thromboxane B2 | 1996 |
Antinociceptive activities of 70% methanol extract of evodiae fructus (fruit of Evodia rutaecarpa var. bodinieri) and its alkaloidal components.
Topics: Alkaloids; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; China; Chromatography, High Pressure Liquid; Indole Alkaloids; Limonins; Male; Mice; Mice, Inbred Strains; Motor Activity; Pain Measurement; Plant Extracts; Plants, Medicinal; Quinazolines; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Triterpenes; Vasodilator Agents | 1997 |
Studies of the cellular mechanisms underlying the vasorelaxant effects of rutaecarpine, a bioactive component extracted from an herbal drug.
Topics: Acetylcholine; Alkaloids; Animals; Aorta, Thoracic; Calcimycin; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Estrenes; Gallic Acid; Guanylate Cyclase; Histamine; Indole Alkaloids; Ionophores; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Pertussis Toxin; Phenylephrine; Pyrrolidinones; Quinazolines; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Vasodilator Agents; Virulence Factors, Bordetella | 1997 |
Vasorelaxing action of rutaecarpine: effects of rutaecarpine on calcium channel activities in vascular endothelial and smooth muscle cells.
Topics: 4-Aminopyridine; Alkaloids; Animals; Aorta, Thoracic; Calcium; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Hydroquinones; In Vitro Techniques; Indole Alkaloids; Isometric Contraction; Male; Membrane Potentials; Models, Cardiovascular; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Patch-Clamp Techniques; Potassium Channel Blockers; Quinazolines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1999 |
A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Electrophoresis, Polyacrylamide Gel; Fruit; Humans; Immunoblotting; Indole Alkaloids; Inflammation; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Plant Extracts; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Quinazolines; Rats; Rats, Sprague-Dawley; Transfection | 1999 |
In vitro relaxation of rabbit and human internal anal sphincter by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa.
Topics: Acetylcholine; Alkaloids; Anal Canal; Animals; Calcium; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Edetic Acid; Enzyme Inhibitors; Ethylmaleimide; Humans; In Vitro Techniques; Indole Alkaloids; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nifedipine; Quinazolines; Rabbits; Species Specificity; Vasodilator Agents | 2000 |
Antithrombotic effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, on platelet plug formation in in vivo experiments.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Aspirin; Bleeding Time; Blood Pressure; Drugs, Chinese Herbal; Fluorescein; Indole Alkaloids; Mice; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Quinazolines; Rats; Rats, Sprague-Dawley | 2000 |
The positive inotropic and chronotropic effects of evodiamine and rutaecarpine, indoloquinazoline alkaloids isolated from the fruits of Evodia rutaecarpa, on the guinea-pig isolated right atria: possible involvement of vanilloid receptors.
Topics: Alkaloids; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cardiotonic Agents; Dose-Response Relationship, Drug; Fruit; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Indole Alkaloids; Male; Myocardial Contraction; Plant Extracts; Platelet Aggregation Inhibitors; Purinergic Antagonists; Pyridoxal Phosphate; Quinazolines; Receptors, Drug; Rosales; Ruthenium Red; Stimulation, Chemical | 2001 |
Rutaecarpine, a quinazolinocarboline alkaloid, inhibits prostaglandin production in RAW264.7 macrophages.
Topics: Alkaloids; Animals; Arachidonic Acid; Cell Survival; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fruit; Indole Alkaloids; Isoenzymes; Macrophages; Magnoliopsida; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Quinazolines; Rodentia | 2001 |
Rutaecarpine-induced block of delayed rectifier K+ current in NG108-15 neuronal cells.
Topics: Action Potentials; Alkaloids; Animals; Calcium Channels; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Indole Alkaloids; Ion Channel Gating; Kinetics; Membrane Potentials; Mice; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quinazolines; Rats; Tumor Cells, Cultured; Vasodilator Agents | 2001 |
Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa.
Topics: Administration, Oral; Alkaloids; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Induction; Immunoblotting; Indole Alkaloids; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Quinazolines | 2001 |
The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.
Topics: Alkaloids; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; In Vitro Techniques; Indole Alkaloids; Kinetics; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidoreductases; Plant Extracts; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Theophylline | 2002 |
Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice.
Topics: Alkaloids; Animals; Cell Fractionation; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Drugs, Chinese Herbal; Glucuronosyltransferase; Glutathione Transferase; Humans; Indole Alkaloids; Liver; Male; Methanol; Mice; Mice, Inbred C57BL; Oxazines; Plant Extracts; Plants, Medicinal; Quinazolines; Rutaceae | 2002 |
The cardioprotection of rutaecarpine is mediated by endogenous calcitonin related-gene peptide through activation of vanilloid receptors in guinea-pig hearts.
Topics: Alkaloids; Animals; Calcitonin Gene-Related Peptide; Cardiotonic Agents; Creatine Kinase; Dose-Response Relationship, Drug; Evodia; Fruit; Guinea Pigs; Heart Ventricles; Indole Alkaloids; Male; Molecular Structure; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Plants, Medicinal; Quinazolines; Radioimmunoassay; Receptors, Drug; Ventricular Pressure | 2002 |
The depressor and vasodilator effects of rutaecarpine are mediated by calcitonin gene-related peptide.
Topics: Alkaloids; Animals; Aorta; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Evodia; Fruit; Indole Alkaloids; Injections, Intravenous; Injections, Subcutaneous; Male; Mesenteric Arteries; Phytotherapy; Quinazolines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2003 |
Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells.
Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Division; Cysteine Proteinase Inhibitors; Dactinomycin; DNA Fragmentation; Drug Screening Assays, Antitumor; Enzyme Activation; Evodia; Fibrosarcoma; Fluorouracil; Furans; Gene Expression Regulation, Neoplastic; Genes, bcl-2; HeLa Cells; Hepatocytes; Heterocyclic Compounds, 4 or More Rings; Humans; Indole Alkaloids; Leukemia, Monocytic, Acute; Leukocytes, Mononuclear; Melanoma; Mice; Mitochondria; Molecular Structure; Neoplasm Proteins; Oligopeptides; Plant Extracts; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Rats; Rats, Inbred BUF; Sarcoma 180; Tumor Cells, Cultured | 2003 |
Involvement of capsaicin-sensitive sensory nerves in cardioprotection of rutaecarpine in rats.
Topics: Alkaloids; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cardiotonic Agents; Creatine Kinase; Heart; Indole Alkaloids; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Neurons, Afferent; Organ Size; Quinazolines; Rats; Rats, Wistar | 2003 |
[Determination of evodiamine and rutaecarpine in Evodia rutaecarpa (Juss.) Benth after compatibility with Coptis chinensis Franch].
Topics: Alkaloids; Coptis; Drug Combinations; Drugs, Chinese Herbal; Evodia; Indole Alkaloids; Plant Extracts; Plants, Medicinal; Quinazolines | 2001 |
Effect of structural modification on the inhibitory selectivity of rutaecarpine derivatives on human CYP1A1, CYP1A2, and CYP1B1.
Topics: Alkaloids; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP1B1; Enzyme Inhibitors; Humans; Hydrogen Bonding; Indole Alkaloids; Models, Molecular; Molecular Conformation; Quinazolines; Structure-Activity Relationship | 2003 |
Characterization of in vitro metabolites of rutaecarpine in rat liver microsomes using liquid chromatography/tandem mass spectrometry.
Topics: Alkaloids; Animals; Chromatography, High Pressure Liquid; Hydroxylation; In Vitro Techniques; Indole Alkaloids; Male; Microsomes, Liver; Molecular Structure; Protons; Quinazolines; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2004 |
Stimulation of calcitonin gene-related peptide synthesis and release: mechanisms for a novel antihypertensive drug, rutaecarpine.
Topics: Alkaloids; Animals; Antihypertensive Agents; Blood Pressure; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Hypertension; Indole Alkaloids; Male; Mesenteric Arteries; Quinazolines; Rats; Rats, Sprague-Dawley; Spinal Cord | 2004 |
Induction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450s.
Topics: Alkaloids; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Evodia; Fruit; Immunoblotting; Indole Alkaloids; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Phytotherapy; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley | 2004 |
Inhibition of UVA irradiation-modulated signaling pathways by rutaecarpine, a quinazolinocarboline alkaloid, in human keratinocytes.
Topics: Acetylcysteine; Alkaloids; Blotting, Western; Cell Line; Cell Survival; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; Hydrogen Peroxide; Indole Alkaloids; Keratinocytes; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Quinazolines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tretinoin; Ultraviolet Rays | 2004 |
[Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth].
Topics: Alkaloids; Carbolines; Evodia; Fruit; Indole Alkaloids; Molecular Structure; Plant Extracts; Plants, Medicinal; Quinazolines | 2004 |
Involvement of CGRP in the inhibitory effect of rutaecarpine on vasoconstriction induced by anaphylaxis in guinea pig.
Topics: Alkaloids; Anaphylaxis; Animals; Antigens; Aorta, Thoracic; Calcitonin Gene-Related Peptide; Capsaicin; Diphenhydramine; Female; Guinea Pigs; Indole Alkaloids; Male; Quinazolines; Receptors, Drug; Time Factors; TRPV Cation Channels; Vasoconstriction; Vasodilator Agents | 2005 |
Protective effects of rutaecarpine in cardiac anaphylactic injury is mediated by CGRP.
Topics: Alkaloids; Anaphylaxis; Animals; Blood Pressure; Cardiotonic Agents; Coronary Vessels; Evodia; Female; Guinea Pigs; Heart; Heart Rate; Indole Alkaloids; Male; Myocardium; Phytotherapy; Quinazolines; Tumor Necrosis Factor-alpha | 2004 |
Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion.
Topics: Active Transport, Cell Nucleus; Alkaloids; Annexin A5; Apoptosis; Carcinogens; Cell Line, Tumor; Cell Proliferation; Collagen; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Enzyme Activation; Evodia; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; I-kappa B Kinase; Immunohistochemistry; Immunoprecipitation; In Situ Nick-End Labeling; Indole Alkaloids; Inflammation; Laminin; MAP Kinase Signaling System; Microscopy, Fluorescence; Models, Chemical; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Protein Serine-Threonine Kinases; Proteoglycans; Quinazolines; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats.
Topics: Alkaloids; Animals; Area Under Curve; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Induction; Evodia; Half-Life; Indole Alkaloids; Intubation, Gastrointestinal; Kidney; Lung; Male; Microdialysis; Microsomes, Liver; Oxazines; Plants, Medicinal; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Theophylline; Time Factors | 2005 |
Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Indole Alkaloids; Quinazolines; Structure-Activity Relationship; Tacrine | 2005 |
Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Evodia; Fruit; Humans; Indole Alkaloids; Kinetics; Limonins; Magnetic Resonance Spectroscopy; Microsomes, Liver; Plant Extracts; Quinazolines | 2005 |
The protective effects of rutaecarpine on gastric mucosa injury in rats.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Evodia; Female; Gastric Mucosa; Indole Alkaloids; Male; Phytotherapy; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2005 |
Identification of the microsomal oxidation metabolites of rutaecarpine, a main active alkaloid of the medicinal herb Evodia rutaecarpa.
Topics: Alkaloids; Animals; Chromatography, High Pressure Liquid; Evodia; Indole Alkaloids; Microsomes, Liver; Oxidation-Reduction; Quinazolines; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2005 |
Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats.
Topics: Administration, Oral; Alkaloids; Animals; Area Under Curve; Bile; Brain; Caffeine; Drug Interactions; Drugs, Chinese Herbal; Evodia; Indole Alkaloids; Infusions, Intravenous; Male; Phytotherapy; Plant Extracts; Quinazolines; Quinolines; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Vasodilator Agents | 2005 |
Physicochemical characterization of rutaecarpine-loaded microemulsion system.
Topics: Alkaloids; Emulsions; Ethanol; Indole Alkaloids; Oils; Platelet Aggregation Inhibitors; Polyethylene Glycols; Polysorbates; Quinazolines; Solubility; Surface-Active Agents; Vasodilator Agents; Water | 2005 |
Characterization of human liver cytochrome P450 enzymes involved in the metabolism of rutaecarpine.
Topics: Alkaloids; Anti-Inflammatory Agents; Chemistry, Pharmaceutical; Chromatography; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Indole Alkaloids; Ions; Liver; Lymphocytes; Microsomes, Liver; Models, Chemical; Quinazolines; Technology, Pharmaceutical | 2006 |
Immunosuppressive effects of rutaecarpine in female BALB/c mice.
Topics: Alkaloids; Animals; Antibody Formation; Body Weight; Cell Cycle; Dose-Response Relationship, Drug; Female; Immunosuppression Therapy; Indole Alkaloids; Interleukin-2; Mice; Mice, Inbred BALB C; Organ Size; Quinazolines; Spleen; Vasodilator Agents | 2006 |
Characterization of the Phase II metabolites of rutaecarpine in rat by liquid chromatography-electrospray ionization-tandem mass spectrometry.
Topics: Alkaloids; Animals; Bile; Chromatography, Liquid; Glucuronides; Indole Alkaloids; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Sulfates | 2005 |
Oxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450.
Topics: Alkaloids; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Escherichia coli; Humans; Hydroxylation; In Vitro Techniques; Indole Alkaloids; Isoenzymes; Kinetics; Microsomes, Liver; Oxidation-Reduction; Protein Binding; Quinazolines | 2006 |
Development and validation of HPLC methods for the analysis of phenethylamine and indoloquinazoline alkaloids in Evodia species.
Topics: Chromatography, High Pressure Liquid; Evodia; Fruit; Indole Alkaloids; Medicine, Chinese Traditional; Molecular Structure; Phenethylamines; Plant Extracts; Plants, Medicinal; Polyethylene Glycols; Psychotropic Drugs; Quinazolines; Reproducibility of Results; Solvents; Stereoisomerism; Synephrine; Vasoconstrictor Agents; Vasodilator Agents | 2006 |
Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Calcimycin; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Evodia; Fruit; Indole Alkaloids; Leukotriene C4; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages; Mice; NF-kappa B; Plant Extracts; Quinazolines | 2006 |
Determination of evodiamine and rutecarpine in human serum by liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Evodia; Humans; Indole Alkaloids; Mass Spectrometry; Plant Extracts; Quinazolines; Reproducibility of Results; Tandem Mass Spectrometry | 2006 |
Elimination of rutaecarpine and its metabolites in rat feces and urine measured by liquid chromatography.
Topics: Alkaloids; Animals; Chromatography, High Pressure Liquid; Feces; Indole Alkaloids; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms | 2006 |
Chemical and biological comparisons on Evodia with two related species of different locations and conditions.
Topics: Alkaloids; Animals; Aorta; China; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Evodia; Female; Fruit; In Vitro Techniques; Indole Alkaloids; Male; Methanol; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Myometrium; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Species Specificity; Synephrine; Taiwan | 2006 |
Anti-inflammatory effects and mechanisms of the ethanol extract of Evodia rutaecarpa and its bioactive components on neutrophils and microglial cells.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Cell Line; Ethanol; Evodia; Humans; Hydrazines; Indole Alkaloids; Mice; Microglia; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Picrates; Plant Extracts; Quinazolines; Reactive Oxygen Species; Synephrine; Tetradecanoylphorbol Acetate | 2007 |
Radical reactions with 3H-quinazolin-4-ones: synthesis of deoxyvasicinone, mackinazolinone, luotonin A, rutaecarpine and tryptanthrin.
Topics: Alkaloids; Cyclization; Free Radicals; Indole Alkaloids; Molecular Structure; Pyrroles; Quinazolines; Quinazolinones; Quinones | 2007 |
In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents.
Topics: Alkaloids; Animals; Anti-Allergic Agents; Behavior, Animal; Cell Degranulation; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Evodia; Fruit; Indole Alkaloids; Interleukin-4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Plant Extracts; Pruritus; Quinazolines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2007 |
Short communication: in vivo evaluation of microemulsion system for oral and parenteral delivery of rutaecarpine to rats.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Castor Oil; Drug Stability; Drug Storage; Emulsions; Excipients; Indole Alkaloids; Injections, Intravenous; Male; Polyethylene Glycols; Polysorbates; Quinazolines; Rats; Rats, Sprague-Dawley; Solubility; Suspensions; Vasodilator Agents; Water | 2007 |
[Methodological studies on equivalent relationship between granule for clinical prescription and clinical decoction of fructus evodiae].
Topics: Alkaloids; Animals; Drugs, Chinese Herbal; Evodia; Female; Fruit; Hot Temperature; Indole Alkaloids; Male; Mice; Mice, Inbred ICR; Pain Threshold; Plant Extracts; Plants, Medicinal; Quinazolines; Technology, Pharmaceutical | 2007 |
Calcitonin gene-related Peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats.
Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Vessels; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Renovascular; Hypertrophy; Hypotension; Indole Alkaloids; Losartan; Male; Mesenteric Artery, Superior; Muscle, Smooth, Vascular; Quinazolines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Vasodilator Agents | 2007 |
Rutaecarpine induces chloride secretion across rat isolated distal colon.
Topics: Animals; Biological Transport; Chloride Channels; Chlorides; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; In Vitro Techniques; Indole Alkaloids; Potassium Channels; Quinazolines; Rats | 2008 |
Molecular authentication and quality control using a high performance liquid chromatography technique of Fructus Evodiae.
Topics: Chromatography, High Pressure Liquid; DNA Fingerprinting; DNA, Plant; Evodia; Indole Alkaloids; Quality Control; Quinazolines; Species Specificity | 2008 |
The effects of rutaecarpine on the pharmacokinetics of acetaminophen in rats.
Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A2; Cytochromes; Drug Interactions; Indole Alkaloids; Male; Quinazolines; Rats; Rats, Sprague-Dawley | 2007 |
One-pot synthesis of simple alkaloids: 2,3-polymethylene-4(3H)-quinazolinones, luotonin A, tryptanthrin, and rutaecarpine.
Topics: Chemical Phenomena; Chemistry, Physical; Indicators and Reagents; Indole Alkaloids; Lactams; Magnetic Resonance Spectroscopy; ortho-Aminobenzoates; Pyrroles; Quinazolines; Quinazolinones; Quinones; Spectrophotometry, Infrared | 2008 |
Calcitonin gene-related peptide-mediated antihypertensive and anti-platelet effects by rutaecarpine in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Platelets; Blood Pressure; Calcitonin Gene-Related Peptide; Cardiotonic Agents; Hypertension; Indole Alkaloids; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinazolines; Random Allocation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thromboplastin; Vasodilator Agents | 2008 |
The permeability and the efflux of alkaloids of the Evodiae fructus in the Caco-2 model.
Topics: Alkaloids; Biological Transport, Active; Caco-2 Cells; Chromatography, High Pressure Liquid; Evodia; Humans; Indole Alkaloids; Intestinal Absorption; Permeability; Plant Extracts; Quinazolines | 2009 |
Induction of NAD(P)H: quinone reductase by rutaecarpine isolated from the fruits of Evodia rutaecarpa in the murine hepatic Hepa-1c1c7 cell line.
Topics: Animals; Cell Line, Tumor; Chemoprevention; Evodia; Fruit; Indole Alkaloids; Mice; Plant Extracts; Quinazolines; Quinone Reductases | 2008 |
Rutaecarpine inhibits hypoxia/reoxygenation-induced apoptosis in rat hippocampal neurons.
Topics: Animals; Apoptosis; Caspase 3; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Female; Hippocampus; Hypoxia; In Situ Nick-End Labeling; Indole Alkaloids; Neural Inhibition; Neurons; Oxidative Stress; Oxygen; Pregnancy; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Vasodilator Agents | 2008 |
Reduction of asymmetric dimethylarginine in the protective effects of rutaecarpine on gastric mucosal injury.
Topics: Amidohydrolases; Animals; Anti-Ulcer Agents; Arginine; Calcitonin Gene-Related Peptide; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Indicators and Reagents; Indole Alkaloids; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Protective Agents; Quinazolines; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2008 |
Quality evaluation of Evodia rutaecarpa (Juss.) Benth by high performance liquid chromatography with photodiode-array detection.
Topics: Calibration; Chromatography, High Pressure Liquid; Cluster Analysis; Drug Stability; Evodia; Indole Alkaloids; Limonins; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Structure; Plant Extracts; Principal Component Analysis; Quality Control; Quercetin; Quinazolines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solvents; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2008 |
Solid dispersion of rutaecarpine improved its antihypertensive effect in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcitonin Gene-Related Peptide; Dosage Forms; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypertension; Indole Alkaloids; Quinazolines; Rats; Rats, Inbred SHR; RNA, Messenger; Vasodilator Agents | 2008 |
Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Carboxypeptidases; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Renovascular; Hypertrophy; Indole Alkaloids; Kallikreins; Losartan; Male; Mesenteric Arteries; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2009 |
Calcitonin gene-related peptide mediates the cardioprotective effects of rutaecarpine against ischaemia-reperfusion injury in spontaneously hypertensive rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Cardiotonic Agents; Hypertension; Indole Alkaloids; Male; Myocardial Reperfusion Injury; Quinazolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2009 |
Evodiamine and rutaecarpine inhibit migration by LIGHT via suppression of NADPH oxidase activation.
Topics: Cell Line; Cell Movement; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Humans; Immunoblotting; Indole Alkaloids; Intercellular Adhesion Molecule-1; Monocytes; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Plant Extracts; Protein Serine-Threonine Kinases; Quinazolines; Reactive Oxygen Species; Receptors, CCR2; Tumor Necrosis Factor Ligand Superfamily Member 14 | 2009 |
Isolation of secondary metabolites from Hortia oreadica (Rutaceae) leaves through high-speed counter-current chromatography.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cinnamates; Countercurrent Distribution; Humans; Indole Alkaloids; Inhibitory Concentration 50; Limonins; Plant Extracts; Plant Leaves; Plasmodium falciparum; Quinazolines; Quinolines; Rutaceae; Trypanosoma brucei rhodesiense | 2009 |
Synthesis and vasodilator effects of rutaecarpine analogues which might be involved transient receptor potential vanilloid subfamily, member 1 (TRPV1).
Topics: Animals; Chromatography, High Pressure Liquid; In Vitro Techniques; Indole Alkaloids; Magnetic Resonance Spectroscopy; Quinazolines; Rats; TRPV Cation Channels; Vasodilator Agents | 2009 |
A flexible synthesis of 2,3-disubstituted indoles from aminobenzyl phosphonium salts. A direct synthesis of rutaecarpine.
Topics: Aldehydes; Cyclization; Indole Alkaloids; Molecular Structure; Organophosphorus Compounds; Quinazolines; Salts; Stereoisomerism | 2009 |
Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats.
Topics: 3-Hydroxysteroid Dehydrogenases; 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Cholesterol Side-Chain Cleavage Enzyme; Colforsin; Corticosterone; Cyclic AMP; Desoxycorticosterone; Drugs, Chinese Herbal; Evodia; Hydroxycholesterols; Indole Alkaloids; Male; Phosphoproteins; Plant Extracts; Pregnenolone; Progesterone; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasodilator Agents; Zona Fasciculata; Zona Reticularis | 2009 |
[Study on vitro release and transdermal behaviors of Yulian cataplasm].
Topics: Animals; Berberine; Berberine Alkaloids; Drugs, Chinese Herbal; Indole Alkaloids; Mice; Plant Extracts; Quinazolines; Skin; Skin Absorption | 2009 |
Rutecarpine ameliorates bodyweight gain through the inhibition of orexigenic neuropeptides NPY and AgRP in mice.
Topics: Agouti-Related Protein; Animals; Cell Line; Down-Regulation; Eating; Hypothalamus; Indole Alkaloids; Mice; Mice, Inbred C57BL; Neurons; Neuropeptide Y; Obesity; Promoter Regions, Genetic; Quinazolines; Weight Gain | 2009 |
Up-regulation of CYP1A1 by rutaecarpine is dependent on aryl hydrocarbon receptor and calcium.
Topics: Animals; Azo Compounds; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Chelating Agents; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Egtazic Acid; Enzyme Induction; Indole Alkaloids; Liver; Mice; Phosphorylation; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyrazoles; Quinazolines; Receptors, Aryl Hydrocarbon; RNA, Messenger; Sulfonamides | 2009 |
Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Indole Alkaloids; Magnetic Resonance Spectroscopy; Models, Molecular; Quinazolines; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2010 |
[Assay of evodin, evodiamine and rutaecarpine in Fructus Evodiae by QAMS].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Evodia; Furans; Heterocyclic Compounds, 4 or More Rings; Indole Alkaloids; Plant Extracts; Quinazolines | 2009 |
[Determination of evodiamine and rutaecarpine of compound Wuzhuyu cataplasm in plasma by SPE-HPLC: application to its pharmacokinetics].
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Indole Alkaloids; Male; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Solid Phase Extraction | 2009 |
Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide.
Topics: Adult; Adult Stem Cells; Angiotensin II; Animals; Base Sequence; Calcitonin Gene-Related Peptide; Capsaicin; Cellular Senescence; DNA Primers; Endothelial Cells; Female; Humans; Hypertension; In Vitro Techniques; Indole Alkaloids; Male; Middle Aged; Quinazolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; TRPV Cation Channels | 2010 |
Regulation of dioxin receptor function by different beta-carboline alkaloids.
Topics: Alkaloids; Carbolines; Cytochrome P-450 CYP1A1; Gene Expression; Gene Expression Regulation; Hep G2 Cells; Humans; Indole Alkaloids; Pyrimidines; Quinazolines; Receptors, Aryl Hydrocarbon | 2010 |
Anti-proliferative effects of evodiamine on human thyroid cancer cell line ARO.
Topics: Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Evodia; G2 Phase; Humans; In Situ Nick-End Labeling; Indole Alkaloids; Plant Extracts; Poly(ADP-ribose) Polymerases; Quinazolines; Thyroid Neoplasms; Time Factors | 2010 |
A new quinolone and other constituents from the fruits of Tetradium ruticarpum: effects on neutrophil pro-inflammatory responses.
Topics: Anti-Inflammatory Agents; Evodia; Fruit; Humans; Indole Alkaloids; Molecular Structure; Neutrophils; Pancreatic Elastase; Plant Extracts; Quinazolines; Quinolines; Quinolones; Superoxides | 2010 |
Investigation on fragmentation pathways of rutaecarpine and its two derivatives using electrospray ionization ion-trap time-of-flight tandem mass spectrometry.
Topics: Drugs, Chinese Herbal; Indole Alkaloids; Quinazolines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Synthesis and biological properties of benzo-annulated rutaecarpines.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; Indole Alkaloids; Neoplasms; Phytotherapy; Plant Extracts; Quinazolines; Rutaceae; Structure-Activity Relationship | 2010 |
Reversal of isoprenaline-induced cardiac remodeling by rutaecarpine via stimulation of calcitonin gene-related peptide production.
Topics: Animals; Apoptosis; Body Weight; Calcitonin Gene-Related Peptide; Echocardiography; Ganglia, Spinal; Heart Ventricles; In Situ Nick-End Labeling; Indole Alkaloids; Isoproterenol; Male; Myocytes, Cardiac; Organ Size; Quinazolines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Ventricular Remodeling | 2010 |
On carpine ruté
Topics: Indole Alkaloids; Quinazolines | 1945 |
Optimization of extraction of evodiamine and rutaecarpine from fruit of Evodia rutaecarpa using modified supercritical CO(2).
Topics: Algorithms; Analysis of Variance; Carbon Dioxide; Chemical Fractionation; Chromatography, High Pressure Liquid; Evodia; Fruit; Indole Alkaloids; Methanol; Plant Extracts; Pressure; Quinazolines; Temperature; Time Factors | 2010 |
Rutaecarpine prevents hypoxia-reoxygenation-induced myocardial cell apoptosis via inhibition of NADPH oxidases.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Hypoxia; Cell Survival; Enzyme Inhibitors; Indole Alkaloids; Myocytes, Cardiac; NADPH Oxidases; Oxygen; Quinazolines; Rats | 2011 |
Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Drug Interactions; Enzyme Induction; Indole Alkaloids; Quinazolines; Rats; Rats, Sprague-Dawley; Theobromine; Theophylline; Vasodilator Agents | 2011 |
[Effect and mechanisms of rutaecarpine on treating atopic dermatitis in mice].
Topics: Animals; Dermatitis, Atopic; Female; Immunoglobulin E; Indole Alkaloids; Interferon-gamma; Interleukin-4; Male; Mice; Quinazolines | 2011 |
[Optimization of a HPLC determination method for Evodia rutaecarpa].
Topics: Chromatography, High Pressure Liquid; Evodia; Indole Alkaloids; Limonins; Plant Extracts; Quinazolines | 2011 |
[Determination of evodiamine and rutacarpine in zhuyu hewei zhitong capsules by HPLC].
Topics: Alkaloids; Capsules; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Linear Models; Quality Control; Quinazolines; Reproducibility of Results | 2011 |
Bicyclic 1,2,3-triazolium ionic liquids: synthesis, characterization, and application to rutaecarpine synthesis.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Indole Alkaloids; Ionic Liquids; Molecular Structure; Quinazolines; Triazoles | 2011 |
Enhanced transdermal delivery of evodiamine and rutaecarpine using microemulsion.
Topics: Administration, Cutaneous; Animals; Emulsions; Indole Alkaloids; Male; Microdialysis; Microscopy, Electron, Transmission; Pharmaceutical Vehicles; Quinazolines; Rats; Rats, Sprague-Dawley; Skin Absorption | 2011 |
Pharmacokinetic comparisons of rutaecarpine and evodiamine after oral administration of Wu-Chu-Yu extracts with different purities to rats.
Topics: Administration, Oral; Alkaloids; Animals; Biological Availability; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Drugs, Chinese Herbal; Evodia; Indole Alkaloids; Intestinal Absorption; Male; Plant Extracts; Quinazolines; Quinolines; Rats; Rats, Sprague-Dawley; Reference Standards | 2012 |
Simultaneous determination of evodiamine and rutecarpine in rabbit plasma by LC-ESI-MS and its application to pharmacokinetics.
Topics: Animals; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Half-Life; Indicators and Reagents; Indole Alkaloids; Injections, Intravenous; Male; Quinazolines; Rabbits; Reference Standards; Reproducibility of Results; Solutions; Spectrometry, Mass, Electrospray Ionization | 2011 |
[Synthesis, physicochemical and pharmacological properties of pentacyclic alkaloid-analogues].
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Survival; Drugs, Chinese Herbal; Evodia; HeLa Cells; Humans; Indole Alkaloids; Piroxicam; Plant Extracts; Quinazolines; Therapeutic Equivalency | 2011 |
[Studies on pharmacokinetics of evodiamine and rutaecarpine in rats plasma after oral administration extracts of euodiae fructus].
Topics: Administration, Oral; Animals; Evodia; Indole Alkaloids; Male; Plant Extracts; Quinazolines; Rats; Rats, Wistar | 2011 |
Simultaneous determination and pharmacokinetic analysis of seven alkaloids and two flavonoids from rat plasma by HPLC-DAD after oral administration of Wuzhuyu decoction.
Topics: Administration, Oral; Alkaloids; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Indole Alkaloids; Male; Molecular Structure; Quinazolines; Rats | 2012 |
2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Design; Indole Alkaloids; Inhibitory Concentration 50; Kinetics; Models, Molecular; Molecular Docking Simulation; Quinazolines; Structure-Activity Relationship | 2013 |
Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo.
Topics: Administration, Cutaneous; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Evodia; Female; Indole Alkaloids; Male; Mice; Oleic Acid; Pain; Plant Extracts; Quinazolines; Sesquiterpenes; Skin; Swine | 2012 |
New glycosidic alkaloid from the nearly ripe fruits of Euodia rutaecarpa.
Topics: Alkaloids; Drugs, Chinese Herbal; Evodia; Fruit; Indole Alkaloids; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Quinazolines | 2012 |
New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases.
Topics: Cell Line, Tumor; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Indole Alkaloids; Quinazolines; Rutaceae; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2012 |
In vitro cellular uptake of evodiamine and rutaecarpine using a microemulsion.
Topics: Animals; Emulsions; Fibroblasts; Indole Alkaloids; Mice; Microscopy, Confocal; Nanoparticles; NIH 3T3 Cells; Particle Size; Quinazolines; Rhodamines | 2012 |
Simultaneous determination of six bioactive compounds in Evodiae Fructus by high-performance liquid chromatography with diode array detection.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Evodia; Fruit; Indole Alkaloids; Limonins; Plant Extracts; Quinazolines; Reproducibility of Results; Triterpenes | 2014 |
Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Biocatalysis; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indole Alkaloids; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Molecular Structure; Peptide Fragments; Protein Binding; Protein Structure, Tertiary; Quinazolines | 2013 |
Rutaecarpine effects on expression of hepatic phase-1, phase-2 metabolism and transporter genes as a basis of herb-drug interactions.
Topics: Administration, Oral; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Herb-Drug Interactions; Indole Alkaloids; Liver; Male; Membrane Transport Proteins; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Mice; Plant Extracts; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Substrate Specificity; Sulfotransferases; Up-Regulation | 2013 |
Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Benzophenanthridines; Dioxoles; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Indole Alkaloids; Lignans; Plants, Medicinal; Quinazolines; Quinolines; Zanthoxylum | 2013 |
Rutaecarpine inhibits angiotensin II-induced proliferation in rat vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Base Sequence; Cell Proliferation; Cells, Cultured; DNA Primers; Hemeproteins; Indole Alkaloids; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-myc; Quinazolines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
Rutaecarpine analogues reduce lipid accumulation in adipocytes via inhibiting adipogenesis/lipogenesis with AMPK activation and UPR suppression.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Indole Alkaloids; Lipid Metabolism; Lipogenesis; Male; Mice; Molecular Structure; Quinazolines; Unfolded Protein Response; Vasodilator Agents | 2013 |
Low-cytotoxic synthetic bromorutaecarpine exhibits anti-inflammation and activation of transient receptor potential vanilloid type 1 activities.
Topics: Anti-Inflammatory Agents; Cardiovascular Diseases; Drugs, Chinese Herbal; Evodia; Gene Expression Regulation; Humans; Indole Alkaloids; Inflammation; Macrophages; Nitric Oxide Synthase Type II; Quinazolines; TRPV Cation Channels | 2013 |
Evodiamine and rutaecarpine alkaloids as highly selective transient receptor potential vanilloid 1 agonists.
Topics: Animals; Humans; Indole Alkaloids; Models, Molecular; Protein Conformation; Quinazolines; Rabbits; Rats; Substrate Specificity; TRPV Cation Channels | 2014 |
New limonoids from Coptidis Rhizoma-Euodiae Fructus couple.
Topics: Antineoplastic Agents, Phytogenic; Caco-2 Cells; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Evodia; Fruit; Humans; Indole Alkaloids; Limonins; Molecular Structure; Quinazolines; Rhizome | 2014 |
Metabolic activation of the indoloquinazoline alkaloids evodiamine and rutaecarpine by human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.
Topics: Activation, Metabolic; Cytochrome P-450 CYP3A; Humans; Hydrogenation; Indole Alkaloids; Microsomes, Liver; Plant Extracts; Quinazolines | 2014 |
Rutaecarpine suppresses atherosclerosis in ApoE-/- mice through upregulating ABCA1 and SR-BI within RCT.
Topics: Animals; Apolipoproteins E; Atherosclerosis; ATP Binding Cassette Transporter 1; Indole Alkaloids; Liver; Mice; Mice, Knockout; Quinazolines; RAW 264.7 Cells; Scavenger Receptors, Class B | 2014 |
[Fast analysis of indole alkaloids from Evodiae fructus by supercritical fluid chromatography].
Topics: Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Evodia; Indole Alkaloids; Quinazolines | 2014 |
Role of the conformational flexibility of evodiamine in its binding to protein hosts: a comparative spectroscopic and molecular modeling evaluation with rutaecarpine.
Topics: Binding Sites; Circular Dichroism; Humans; Indole Alkaloids; Models, Molecular; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Quinazolines; Serum Albumin; Spectrophotometry, Ultraviolet; Stereoisomerism | 2014 |
[Effects of rutaecarpine on inflammatory cytokines in insulin resistant primary skeletal muscle cells].
Topics: Animals; Cell Proliferation; Cytokines; Female; Glucose; Indole Alkaloids; Inflammation; Insulin Resistance; Male; Muscle, Skeletal; Quinazolines; Rats | 2014 |
Toxicity of Evodiae fructus on rat liver mitochondria: the role of oxidative stress and mitochondrial permeability transition.
Topics: Adenosine Triphosphate; Animals; Cytochromes c; Evodia; Furans; Glutathione; Heterocyclic Compounds, 4 or More Rings; Indole Alkaloids; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria, Liver; Oxidative Stress; Permeability; Plant Extracts; Quinazolines; Rats; Superoxide Dismutase | 2014 |
Identification of evodiamine as the bioactive compound in evodia (Evodia rutaecarpa Benth.) fruit extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ).
Topics: Animals; CHO Cells; Chromans; Chromatography, High Pressure Liquid; Cricetulus; Evodia; Fruit; Hep G2 Cells; Humans; Indole Alkaloids; Mass Spectrometry; Molecular Structure; Plant Extracts; PPAR gamma; Quinazolines; Thiazolidinediones; Troglitazone | 2015 |
[Effects of rutaecarpine on right ventriclar remodeling in rats with monocrotaline-induced pulmonary hypertension].
Topics: Animals; Antioxidants; Heart Ventricles; Hypertension, Pulmonary; Indole Alkaloids; Male; Malondialdehyde; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Quinazolines; Rats; Ventricular Remodeling | 2014 |
Rutaecarpine prevented dysfunction of endothelial gap junction induced by Ox-LDL via activation of TRPV1.
Topics: Cell Communication; Connexins; Gap Junctions; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Indole Alkaloids; Lipoproteins, LDL; Quinazolines; RNA, Messenger; TRPV Cation Channels | 2015 |
Identification of active ingredients in Wuzhuyu decoction improving migraine in mice by spectral efficiency association.
Topics: Animals; Brain; China; Drugs, Chinese Herbal; Ginsenosides; Humans; Indole Alkaloids; Limonins; Medicine, Chinese Traditional; Mice; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Quinazolines; Reserpine; Serotonin | 2015 |
Investigating the molecular and aggregated states of a drug molecule rutaecarpine using spectroscopy, microscopy, crystallography and computational studies.
Topics: Cardiotonic Agents; Colloids; Crystallography; Dimerization; Dynamic Light Scattering; Imidazoles; Indole Alkaloids; Ionic Liquids; Magnetic Resonance Spectroscopy; Models, Molecular; Particle Size; Platelet Aggregation Inhibitors; Quinazolines; Rutaceae; Spectrometry, Fluorescence | 2015 |
Mechanism-based inhibition of CYPs and RMs-induced hepatoxicity by rutaecarpine.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Indole Alkaloids; Quinazolines; Rats | 2015 |
Rutaecarpine and evodiamine selected as β1-AR inhibitor candidates using β1-AR/CMC-offline-UPLC/MS prevent cardiac ischemia-reperfusion injury via energy modulation.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Cell Membrane; Cell Survival; CHO Cells; Chromatography, High Pressure Liquid; Cricetulus; Energy Metabolism; Evodia; Indole Alkaloids; Male; Mass Spectrometry; Myocardial Reperfusion Injury; Quinazolines; Rats, Wistar; Receptors, Adrenergic, beta-1 | 2015 |
Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor.
Topics: Alkaloids; Animals; Constitutive Androstane Receptor; Dose-Response Relationship, Drug; Evodia; Forkhead Box Protein O1; Gene Expression Regulation; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Hypoglycemic Agents; Indole Alkaloids; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoenolpyruvate Carboxykinase (ATP); Primary Cell Culture; Quinazolines; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2016 |
Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment.
Topics: 3T3-L1 Cells; Adipogenesis; AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Cell Cycle Checkpoints; Cholesterol; Hep G2 Cells; Humans; Indole Alkaloids; Lipogenesis; Mice; Protein Serine-Threonine Kinases; Quinazolines; Signal Transduction; Triglycerides | 2015 |
Optimization of combinations of ginsenoside-Rg1, ginsenoside-Rb1, evodiamine and rutaecarpine for effective therapy of mouse migraine.
Topics: Animals; Dopamine; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Indole Alkaloids; Medicine, Chinese Traditional; Mice, Inbred ICR; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Phytotherapy; Quinazolines; Serotonin | 2016 |
Rutaecarpine Reverses the Altered Connexin Expression Pattern Induced by Oxidized Low-density Lipoprotein in Monocytes.
Topics: Adenosine Triphosphate; Atherosclerosis; Cells, Cultured; Connexins; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Indole Alkaloids; Lipoproteins, LDL; Monocytes; Quinazolines; Time Factors | 2016 |
Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways.
Topics: Animals; Dietary Fats; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Indole Alkaloids; Liver; Male; Muscle Cells; Muscle, Skeletal; Pancreas; Quinazolines; Rats, Sprague-Dawley; Signal Transduction; Streptozocin | 2016 |
Rutaecarpine attenuates hypoxia-induced right ventricular remodeling in rats.
Topics: Animals; Apoptosis; Calcitonin Gene-Related Peptide; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Dose-Response Relationship, Drug; Eukaryotic Initiation Factor-3; Fibroblasts; Fibrosis; Hypertrophy, Right Ventricular; Hypoxia; Indole Alkaloids; Myocardium; Quinazolines; Signal Transduction; Transforming Growth Factor beta1; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2016 |
Partial Activation and Inhibition of TRPV1 Channels by Evodiamine and Rutaecarpine, Two Major Components of the Fruits of Evodia rutaecarpa.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Evodia; Fruit; HEK293 Cells; Humans; Indole Alkaloids; Molecular Structure; Quinazolines; TRPV Cation Channels | 2016 |
Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine Based on 3D Tumor Models.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Indole Alkaloids; Inhibitory Concentration 50; Molecular Structure; Plant Extracts; Quinazolines; Spectrum Analysis; Spheroids, Cellular; Tumor Cells, Cultured | 2016 |
Detection and characterization of the metabolites of rutaecarpine in rats based on ultra-high-performance liquid chromatography with linear ion trap-Orbitrap mass spectrometer.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glucuronides; Hydroxylation; Indole Alkaloids; Male; Mass Spectrometry; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Molecular Structure; Quinazolines; Rats, Sprague-Dawley; Solid Phase Extraction; Sulfates | 2017 |
Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways.
Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Survival; Chromatin Immunoprecipitation; Hep G2 Cells; Humans; Indole Alkaloids; Liver; Male; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Protective Agents; Proto-Oncogene Proteins c-akt; Quinazolines; Reactive Oxygen Species; Signal Transduction; tert-Butylhydroperoxide; Up-Regulation; Vasodilator Agents; Vesicular Transport Proteins | 2017 |
Synthetic Fluororutaecarpine Inhibits Inflammatory Stimuli and Activates Endothelial Transient Receptor Potential Vanilloid-Type 1.
Topics: Animals; Anti-Inflammatory Agents; Cell Movement; Cyclooxygenase 2; Endothelial Cells; Endothelium, Vascular; Humans; Indole Alkaloids; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Quinazolines; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2017 |
Rutaecarpine alleviates renal ischemia reperfusion injury in rats by suppressing the JNK/p38 MAPK signaling pathway and interfering with the oxidative stress response.
Topics: Animals; Biomarkers; Biopsy; Blood Urea Nitrogen; Cytokines; Disease Models, Animal; Indole Alkaloids; Inflammation Mediators; Kidney Diseases; Kidney Function Tests; Male; MAP Kinase Signaling System; Oxidative Stress; Phosphorylation; Protective Agents; Quinazolines; Rats; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase | 2017 |
Co-delivery of evodiamine and rutaecarpine in a microemulsion-based hyaluronic acid hydrogel for enhanced analgesic effects on mouse pain models.
Topics: Analgesics; Animals; Dinoprostone; Drug Carriers; Emulsions; Guinea Pigs; Hyaluronic Acid; Hydrogels; Indole Alkaloids; Interleukin-6; Mice; Pain; Quinazolines; Skin Absorption; Tumor Necrosis Factor-alpha | 2017 |
Phase I and phase II metabolite identification of rutaecarpine in freshly isolated hepatocytes from male Sprague-Dawley rats.
Topics: Animals; Chromatography, Liquid; Evodia; Glucuronides; Hepatocytes; Indole Alkaloids; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2017 |
Rutaecarpine Inhibits Intimal Hyperplasia in A Balloon-Injured Rat Artery Model.
Topics: Actins; Animals; Carotid Arteries; Carotid Artery Injuries; Cyclic GMP; Disease Models, Animal; Gene Expression Regulation; Hyperplasia; Indole Alkaloids; Male; Nitric Oxide; Phosphorylation; Proliferating Cell Nuclear Antigen; Quinazolines; Rats, Sprague-Dawley; RNA, Messenger; Tunica Intima | 2018 |
Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility.
Topics: Alkaloids; Antineoplastic Agents; Cell Survival; HeLa Cells; Humans; Hydrogen-Ion Concentration; Indole Alkaloids; Quinazolines; Solubility; Structure-Activity Relationship | 2017 |
Involvement of TRPV1 in the expression and release of calcitonin gene-related peptide induced by rutaecarpine.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Calcium Signaling; Cell Line; Ganglia, Spinal; Gene Expression Regulation; Humans; Indole Alkaloids; Male; Neurons; Quinazolines; Rats; TRPV Cation Channels | 2018 |
Rutaecarpine Suppresses Proliferation and Promotes Apoptosis of Human Pulmonary Artery Smooth Muscle Cells in Hypoxia Possibly Through HIF-1α-Dependent Pathways.
Topics: Apoptosis; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indole Alkaloids; Inhibitory Concentration 50; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Quinazolines; Signal Transduction; Tumor Suppressor Protein p53 | 2018 |
Rutaecarpine attenuates osteoclastogenesis by impairing macrophage colony stimulating factor and receptor activator of nuclear factor κ-B ligand-stimulated signalling pathways.
Topics: Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Indole Alkaloids; Macrophage Colony-Stimulating Factor; Macrophages; Osteoclasts; Osteogenesis; Quinazolines; RANK Ligand; Signal Transduction | 2018 |
Structure-Activity Relationships of the Main Bioactive Constituents of
Topics: Alkaloids; Animals; Bile Acids and Salts; Cell Line, Tumor; Drugs, Chinese Herbal; Evodia; Genes, Reporter; Hep G2 Cells; Hepatocytes; Homeostasis; Humans; Indole Alkaloids; Liver; Male; Mice; Mice, Inbred C57BL; Quinazolines; Receptors, Aryl Hydrocarbon; RNA, Messenger; Structure-Activity Relationship; Up-Regulation | 2018 |
Rutacecarpine Inhibits Angiogenesis by Targeting the VEGFR2 and VEGFR2-Mediated Akt/mTOR/p70s6k Signaling Pathway.
Topics: Angiogenesis Inhibitors; Animals; Cell Movement; Cell Proliferation; Cell Survival; Chick Embryo; Chorioallantoic Membrane; Human Umbilical Vein Endothelial Cells; Humans; Indole Alkaloids; Molecular Docking Simulation; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor Receptor-2 | 2018 |
[Rutaecarpine protects against bleomycin-induced pulmonary fibrosis through inhibiting Notch1/eIF3a signaling pathway in rats].
Topics: Animals; Bleomycin; Eukaryotic Initiation Factor-3; Indole Alkaloids; Male; Pulmonary Fibrosis; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Notch1; Signal Transduction | 2018 |
Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-κB and TLR7 pathways in mice.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Indole Alkaloids; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Quinazolines; Signal Transduction; Skin; Skin Diseases; Th17 Cells; Toll-Like Receptor 7 | 2019 |
Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-
Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Humans; Indole Alkaloids; Lung Neoplasms; Molecular Structure; Pyrimidinones; Quinazolines; Structure-Activity Relationship | 2020 |
Dual-targeting Rutaecarpine-NO donor hybrids as novel anti-hypertensive agents by promoting release of CGRP.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drug Design; Hypertension; Indole Alkaloids; Male; Molecular Structure; Oxadiazoles; Quinazolines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasodilator Agents | 2019 |
Rutaecarpine prevented ox-LDL-induced VSMCs dysfunction through inhibiting overexpression of connexin 43.
Topics: Animals; Cell Movement; Cell Proliferation; Connexin 43; Dose-Response Relationship, Drug; Gene Expression Regulation; Indole Alkaloids; Lipoproteins, LDL; Male; Muscle, Smooth, Vascular; NF-kappa B; Phenotype; Quinazolines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Up-Regulation | 2019 |
Bioprospection of anti-inflammatory phytochemicals suggests rutaecarpine and quinine as promising 15-lipoxygenase inhibitors.
Topics: Arachidonate 15-Lipoxygenase; Cyclooxygenase 2; HEK293 Cells; Humans; Indole Alkaloids; Inflammation; Lipoxygenase Inhibitors; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Phytochemicals; Quinazolines; Quinine; Structure-Activity Relationship | 2019 |
Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway.
Topics: ADAM17 Protein; Angiotensin II; Animals; Aorta, Abdominal; Cardiomegaly; Constriction, Pathologic; Gene Expression Regulation; Humans; Hypertension; Indole Alkaloids; MAP Kinase Signaling System; Myocytes, Cardiac; NADPH Oxidase 4; Quinazolines; Rats; Rats, Inbred Dahl; Reactive Oxygen Species | 2019 |
Analysis of Evodiae Fructus by capillary electrochromatography-mass spectrometry with methyl-vinylimidazole functionalized organic polymer monolilth as stationary phases.
Topics: Acetonitriles; Ammonia; Calibration; Capillary Electrochromatography; Drugs, Chinese Herbal; Electrolytes; Evodia; Fruit; Hydrogen-Ion Concentration; Imidazoles; Indole Alkaloids; Limit of Detection; Limonins; Mass Spectrometry; Polymers; Quinazolines; Reference Standards; Reproducibility of Results | 2019 |
[Effect of rutaecarpine on Alzheimer's disease-like cognitive impairments induced by high glucose in rats].
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Glucose; Glycogen Synthase Kinase 3 beta; Indole Alkaloids; Male; Maze Learning; Phosphorylation; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; tau Proteins | 2019 |
Screening of cathepsin B inhibitors in traditional Chinese medicine by capillary electrophoresis with immobilized enzyme microreactor.
Topics: Amaryllidaceae Alkaloids; Cathepsin B; Drug Discovery; Drugs, Chinese Herbal; Electrophoresis, Capillary; Enzymes, Immobilized; Feasibility Studies; Indole Alkaloids; Indolizines; Kaempferols; Molecular Docking Simulation; Quinazolines; Theophylline | 2019 |
Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Heme Oxygenase-1; Indole Alkaloids; Inflammation; Male; MAP Kinase Signaling System; Neurons; NF-E2-Related Factor 2; Oxidative Stress; Quinazolines; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2019 |
Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis.
Topics: Animals; Colitis; Dextran Sulfate; Humans; Hydrogen Peroxide; Indole Alkaloids; Kelch-Like ECH-Associated Protein 1; Mice; Molecular Docking Simulation; NF-E2-Related Factor 2; Quinazolines | 2020 |
Rutaecarpine derivative R3 attenuates atherosclerosis via inhibiting NLRP3 inflammasome-related inflammation and modulating cholesterol transport.
Topics: Animals; Atherosclerosis; Biological Transport, Active; Cholesterol; Indole Alkaloids; Inflammasomes; Inflammation; Macrophages; Mice; Mice, Knockout, ApoE; NLR Family, Pyrin Domain-Containing 3 Protein; Quinazolines | 2020 |
Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinergic Antagonists; Cognitive Dysfunction; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Indole Alkaloids; Mice; Models, Molecular; Molecular Structure; Morris Water Maze Test; Phosphodiesterase 5 Inhibitors; Protein Conformation; Quinazolines; Scopolamine | 2020 |
Rutaecarpine exhibits anti-diabetic potential in high fat diet-multiple low dose streptozotocin induced type 2 diabetic mice and in vitro by modulating hepatic glucose homeostasis.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Glucose; Homeostasis; Hypoglycemic Agents; Indole Alkaloids; Liver; Male; Mice, Inbred C57BL; Quinazolines | 2020 |
Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cisplatin; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Epithelial Cells; Humans; Indole Alkaloids; Kidney Tubules; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Oxidative Stress; Protein Binding; Quinazolines | 2020 |
Rutaecarpine Ameliorated High Sucrose-Induced Alzheimer's Disease Like Pathological and Cognitive Impairments in Mice.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Glycogen Synthase Kinase 3 beta; Indole Alkaloids; Mice; Phosphorylation; Quinazolines; Sucrose | 2021 |
The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis.
Topics: Adipocytes, Beige; Adipocytes, White; AMP-Activated Protein Kinases; Animals; Biological Products; Disease Models, Animal; DNA-Binding Proteins; Drug Evaluation, Preclinical; In Vitro Techniques; Indole Alkaloids; Male; Mice; Mice, Transgenic; Models, Biological; Obesity; Oxygen Consumption; Quinazolines; Signal Transduction; Thermogenesis; Transcription Factors | 2021 |
3-B-RUT, a derivative of RUT, protected against alcohol-induced liver injury by attenuating inflammation and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Indole Alkaloids; Liver; Liver Diseases, Alcoholic; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; Quinazolines; RAW 264.7 Cells | 2021 |
Mechanism of rutaecarpine on ethanol-induced acute gastric ulcer using integrated metabolomics and network pharmacology.
Topics: Animals; Ethanol; Gastric Mucosa; Indole Alkaloids; Male; Metabolomics; Mice; Quinazolines; Rutaceae; Stomach Ulcer | 2021 |
Rutaecarpine administration inhibits cancer cell growth in allogenic TRAMP-C1 prostate cancer mice correlating with immune balance in vivo.
Topics: Animals; Antigens, CD; Antineoplastic Agents, Phytogenic; Body Weight; Cachexia; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytokines; Dose-Response Relationship, Drug; Indole Alkaloids; Lymphocyte Count; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Organ Size; Prostatic Neoplasms; Quinazolines; Spleen; Th1-Th2 Balance; Tumor Necrosis Factor-alpha | 2021 |
Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Indole Alkaloids; Liver; Metformin; Quinazolines; Rats; Up-Regulation | 2021 |
Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum.
Topics: Animals; Cricetulus; Guinea Pigs; Indole Alkaloids; Interstitial Cells of Cajal; Peristalsis; Quinazolines | 2021 |
Rutaecarpine alleviates acute pancreatitis in mice and AR42J cells by suppressing the MAPK and NF-κB signaling pathways via calcitonin gene-related peptide.
Topics: Acute Disease; Animals; Calcitonin; Calcitonin Gene-Related Peptide; Ceruletide; Humans; Indole Alkaloids; Mice; NF-kappa B; Pancreatitis; Quinazolines; Rats | 2021 |
Rutaecarpine, an Alkaloid from
Topics: Alkaloids; Animals; Cell Adhesion Molecules; Cells, Cultured; Evodia; Glycogen Synthase Kinase 3 beta; Humans; Indole Alkaloids; Male; Mice; Mice, Inbred ICR; Microfilament Proteins; Nucleotides, Cyclic; Phosphatidylinositol 3-Kinases; Phosphoproteins; Plant Extracts; Platelet Activation; Platelet Aggregation; Proto-Oncogene Proteins c-akt; Quinazolines; Quinolines; Signal Transduction; Thrombosis | 2021 |
Design, synthesis and biological evaluation of novel evodiamine and rutaecarpine derivatives against phytopathogenic fungi.
Topics: Antifungal Agents; Ascomycota; Botrytis; Dose-Response Relationship, Drug; Drug Design; Fusarium; Indole Alkaloids; Microbial Sensitivity Tests; Molecular Structure; Quinazolines; Rhizoctonia; Structure-Activity Relationship | 2022 |
Rutaecarpine Prevents High Glucose-Induced Endothelial Cell Senescence Through Transient Receptor Potential Vanilloid Subtype 1/ SIRT1 Pathway.
Topics: Calcium; Calcium Signaling; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Cellular Senescence; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Indole Alkaloids; Quinazolines; Sirtuin 1; TRPV Cation Channels; Up-Regulation | 2022 |
Targeting MAPK/NF-κB Pathways in Anti-Inflammatory Potential of Rutaecarpine: Impact on Src/FAK-Mediated Macrophage Migration.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Focal Adhesion Kinase 1; Indole Alkaloids; Interleukin-1beta; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins pp60(c-src); Quinazolines; RAW 264.7 Cells; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2021 |
Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB.
Topics: Animals; Disease Models, Animal; Fibrinolytic Agents; Free Radical Scavengers; Free Radicals; Humans; I-kappa B Kinase; Imidazoles; Indole Alkaloids; Male; Mice, Inbred ICR; NF-kappa B; Nitriles; P-Selectin; p38 Mitogen-Activated Protein Kinases; Platelet Activation; Protein Kinase Inhibitors; Pulmonary Embolism; Pyridines; Quinazolines; Sulfones; Thrombosis; Transcription Factor RelA | 2022 |
Anti-Inflammatory Mechanism of An Alkaloid Rutaecarpine in LTA-Stimulated RAW 264.7 Cells: Pivotal Role on NF-κB and ERK/p38 Signaling Molecules.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Indole Alkaloids; Lipopolysaccharides; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Quinazolines; RAW 264.7 Cells; Teichoic Acids | 2022 |
Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study.
Topics: Antineoplastic Agents; Evodia; Indole Alkaloids; Ligands; Molecular Docking Simulation; Quinazolines; Quinazolinones | 2022 |
Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway.
Topics: Animals; Gastritis, Atrophic; Hedgehog Proteins; Methylnitronitrosoguanidine; Mice; Nitrosoguanidines; Quinazolines; Rats; Signal Transduction | 2023 |