quinazolines has been researched along with raltitrexed in 492 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 176 (35.77) | 18.2507 |
| 2000's | 223 (45.33) | 29.6817 |
| 2010's | 69 (14.02) | 24.3611 |
| 2020's | 24 (4.88) | 2.80 |
| Authors | Studies |
|---|---|
| Bader, H; Beardsley, GP; DeYarman, MT; Freisheim, JH; Galivan, J; Kerwar, SS; Moroson, BA; O'Connor, BM; Rosowsky, A; Russello, O | 1 |
| Bisset, GM; Calvert, AH; Hughes, LR; Jackman, AL; Pawelczak, K | 1 |
| Arredondo, MA; Guimaraes, MA; Rustum, YM; Yin, MB; Zhang, ZG | 1 |
| Fleming, GF; Schilsky, RL | 1 |
| Jackman, AL; Kimbell, R; Ward, WH | 1 |
| Erlichman, C | 1 |
| Gibson, W; Jackman, AL; Jodrell, DI; Stephens, TC | 1 |
| Brown, M; Calvert, AH; Gibson, W; Hughes, LR; Jackman, AL; Judson, IR; Kimbell, R; Taylor, GA | 1 |
| Calvert, AH; Gibson, W; Hughes, LR; Jodrell, DI; Newell, DR | 1 |
| Bensted, JP; Calvert, AH; Clinton, S; Hughes, LR; Jodrell, DI; Morgan, SE; Newell, DR | 1 |
| Bishop, JA; Calvert, AH; Hayter, AJ; Hughes, LR; Jackman, AL; Marsham, PR; O'Connor, BM; Oldfield, J; Wardleworth, JM | 1 |
| Boyle, FT; Brown, M; Gibson, W; Jackman, AL; Kimbell, R | 1 |
| Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R | 1 |
| Calvert, AH; Freemantle, SJ; Jackman, AL; Kelland, LR; Lunec, J | 1 |
| Allegra, CJ; Behan, KA; Drake, JC; Johnston, PG | 1 |
| Panadero, A; Rustum, YM; Voigt, W; Yin, MB | 1 |
| Verweij, J | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Rijnboutt, S; Schornagel, JH; Westerhof, GR | 1 |
| Bonmassar, E; Lu, K; McGuire, JJ; Rustum, YM; Yin, MB | 1 |
| Aherne, GW; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R | 1 |
| Peters, GJ; Pinedo, HM; Telleman, F; van der Wilt, CL; van Triest, B | 1 |
| Bisset, GM; Gibson, W; Jackman, AL; Judson, IR; Kelland, LR; Marsham, PR | 1 |
| Chong, LK; Tattersall, MH | 1 |
| Harrap, KR | 1 |
| Erlichman, C; Hedley, DW; Mitrovski, B; Pressacco, J | 1 |
| Cao, S; Rustum, YM; Yin, MB | 1 |
| Erlichman, C; Mandelbaum, S; Mitrovski, B; Pressacco, J | 1 |
| Erlichman, C; Hedley, DW; Pressacco, J | 1 |
| Gibbs, JF; Rustum, YM; Schöber, C; Slocum, HK; Yin, MB | 1 |
| Clarke, SJ; Jackman, AL; Judson, IR | 2 |
| Rathod, PK; Reshmi, S | 1 |
| Lehman, NL; Moran, RG; Smith, SG | 1 |
| Haile, WH; Heitzman, KJ; McCloskey, DE; McGuire, JJ; Piper, JR; Russell, CA | 1 |
| Erlichman, C; Pressacco, J | 1 |
| Bavetsias, V; Bisset, GM; Calvert, AH; Gibson, W; Harrap, KR; Jackman, AL; Jodrell, DI; Kimbell, R; Smith, MN; Stephens, TC | 1 |
| Boyle, FT; Jackman, AL; McCloskey, ML; Smith, MN; Stephens, TC; Waterman, SE | 1 |
| Aherne, W; Boyle, FT; Hardcastle, A; Jackman, AL; Kimbell, R | 1 |
| Keyomarsi, K; Molnar, G; Pardee, AB; Samet, J | 1 |
| Malmberg, M; Rustum, YM; Slocum, HK; Yin, MB; Zhang, ZG | 1 |
| Herrmann, R | 1 |
| Cunningham, D; Harper, P; Kerr, D; Olver, I; Perez-Manga, G; Rath, U; Seitz, JF; Svensson, C; Van Cutsem, E; Zalcberg, JR | 1 |
| Jackman, AL; Kobayashi, H; Miyachi, H; Skelton, L; Takemura, Y | 1 |
| Gibson, W; Jackman, AL; Kimbell, R; Kobayashi, H; Miyachi, H; Takemura, Y | 3 |
| Adenis, A; Azab, M; Cunningham, D; Francois, E; Green, M; Iveson, A; Schornagel, J; Seymour, I; Van Cutsem, E; Zalcberg, JR | 1 |
| Clarke, SJ; de Boer, M; Hanwell, J; Harrap, KR; Hughes, LR; Jackman, AL; Judson, IR; Kennealey, GT; Planting, A; Smith, R; Verweij, J; Walker, M | 1 |
| Calvert, AH; Jackman, AL | 1 |
| Bleiberg, H | 3 |
| Jansen, G; Jolivet, J; Kathmann, I; Molthoff, C; Pinard, MF; Ratnam, M; Schornagel, JH; Westerhof, R | 1 |
| Azab, M; Cassidy, J; Earl, HM; Gore, ME; Mansi, J; Seymour, L; Tattersall, M | 1 |
| Mead, GM | 1 |
| Aiba, K | 1 |
| Bonneterre, J; Green, MD; Hatschek, T; Jones, A; Namer, M; Seymour, L; Smith, I; Spielmann, M; Spiers, J; Wander, HE; Wilking, N; Zalcberg, J | 1 |
| Drengler, R; Eckardt, J; Eckhardt, G; Villalona-Calero, M; Von Hoff, D | 1 |
| Burris, H; Cunningham, D; Gore, M; Kennealey, G; Meropol, NJ; Pazdur, R; Seymour, L; Smith, I; Zalcberg, J | 1 |
| Aherne, GW; Hardcastle, A; Jackman, AL; Raynaud, F | 1 |
| Allegra, CJ; Drake, JC; Johnston, PG; Moran, RG | 1 |
| Hekmat-Nejad, M; Rathod, PK | 1 |
| Abbruzzese, JL; Casper, ES; Douglass, HO; Fuchs, C; Meropol, NJ; Pazdur, R; Vincent, M | 1 |
| Cheson, BD; Phillips, PH; Sorensen, JM | 1 |
| Arredondo, MA; Matsui, SI; Rustum, YM; Wrzosek, C | 1 |
| Hanauske, AR | 1 |
| Ogawa, M | 1 |
| DeGoeij, K; Mester, J; Sluyser, M | 1 |
| Dabrowska, M; Michalski, R; Pawelczak, K; Rode, W; Wranicz, M; Zieliñski, Z | 1 |
| Allegra, CJ; Takimoto, CH | 1 |
| Douglass, HO; Kelsen, DP; Meropol, NJ; Pazdur, R; Vincent, M; Willson, JK | 1 |
| Rutenber, EE; Stroud, RM | 1 |
| Cunningham, D; Heron, J; Ross, P | 1 |
| Boyle, FT; Harrap, KR; Jackman, AL | 1 |
| Cao, S; Harstrick, A; Rustum, YM; Seeber, S; Vanhoefer, U; Wilke, H; Yin, MB | 1 |
| Cunningham, D; Harper, P; Kerr, D; Oliver, I; Perez-Manga, G; Rath, U; Seitz, JF; Svensson, C; van Cutsem, E; Zalcberg, JR | 1 |
| Bavetsias, V; Bisset, GM; Boyle, FT; Jackman, AL; Marshall, D; Pedley, RB; Springer, CJ | 1 |
| Hickman, JA; Jackman, AL; Potten, CS; Pritchard, DM; Watson, AJ | 1 |
| Andis, SL; Beardsley, GP; Bewley, JR; Chen, VJ; Gates, SB; Gossett, LS; Habeck, LL; Kohler, W; MacKellar, WC; Mendelsohn, LG; Moroson, BA; Patel, VF; Ratnam, M; Rayl, EA; Schultz, RM; Shackelford, KA; Shih, C; Soose, DJ | 1 |
| Azizkhan, J; Frank, C; Pajovic, S; Panadero, A; Rustum, YM; Vanhoefer, U; Voigt, W; Yin, MB | 1 |
| Aherne, W; Clarke, S; Hardcastle, A | 1 |
| Bertino, JR; Fan, J; Hochhauser, D; Li, WW | 1 |
| Armand, JP | 1 |
| Adenis, A; Basser, R; Drings, P; Le Chevalier, T; Perez Manga, G; Seymour, L; Smith, F; Thatcher, N; Woll, PJ | 1 |
| Adenis, A; Carr, BI; Ducreux, M; François, E; Kerr, D; Rougier, P; Seymour, L | 1 |
| Bertino, JR; Ercikan, E; Gorlick, R; Longo, GS; Tong, WP | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Telleman, F; van der Wilt, CL; van Triest, B | 1 |
| Borud, K; Isacoff, WH | 1 |
| Faure, MP; Jolivet, J; Matherly, LH; Taub, JW; Wong, SC | 1 |
| Horowitz, RW; Ladner, RD; Schwartz, EL; Wadler, S; Zhang, H | 1 |
| Sobrero, A | 1 |
| Kerr, DJ | 1 |
| Zalcberg, J | 1 |
| Kerr, DJ; O'Connor, KM | 1 |
| Van Cutsem, E | 2 |
| Judson, IR | 1 |
| Dolnick, BJ; Lu, K; Rustum, YM; Yin, MB | 1 |
| Kamen, B | 1 |
| Takimoto, CH | 1 |
| Aherne, GW; Clarke, SJ; Dobinson, D; Jackman, AL; Lawrence, N; Musgrove, H; Stephens, T; Sutcliffe, F; Ward, E | 1 |
| Kobayashi, H; Ohnuma, T; Takemura, Y | 1 |
| Bertino, JR; Chang, YM; Chou, TC; Gorlick, R; Izzo, J; Longo, GS; Tong, WP; Zielinski, Z | 1 |
| Bauer, B; Benter, T; Daniel, PT; Dietz, R; Dörken, B; Friedrich, M; Köhne, CH; Kretzschmar, A; Thuss-Patience, P | 1 |
| Faulds, D; Gunasekara, NS | 1 |
| Kinsella, AR; Smith, D | 1 |
| Anderson, H; Palmer, MK | 1 |
| Cunningham, D | 1 |
| Blackledge, G | 1 |
| Furusho, K; Kubota, M; Wakazono, Y | 1 |
| Aschele, C; Baldo, C; Bertino, JR; Bornmann, WG; Debernardis, D; Sobrero, AF | 1 |
| Chelstrom, LM; Crankshaw, DL; Ek, O; Myers, DE; Reaman, GH; Uckun, FM | 1 |
| Blessing, JA; Homesley, HD; Muggia, FM; Sorosky, J | 1 |
| Aherne, W; Beale, P; Berry, C; Hanwell, J; Hickish, T; Judson, I; Martin, P; Walker, M | 1 |
| Harris, AL; Patterson, AV; Stratford, IJ; Talbot, DC | 1 |
| McCann, J | 1 |
| Ara, G; Chen, YN; Coleman, CN; Recht, A; Teicher, BA | 1 |
| Punt, CJ | 1 |
| Bours, V; Fillet, G; Jerusalem, G | 1 |
| Andis, SL; Bewley, JR; Chen, VJ; Iversen, PW; Mendelsohn, LG; Schultz, RM; Seitz, DE; Shih, C; Tonkinson, JL | 2 |
| Cocconi, G; Cunningham, D; Francois, E; Gustavsson, B; Hietschold, SM; Kerr, D; Possinger, K; Van Cutsem, E; van Hazel, G | 1 |
| Banerjee, D; Bertino, JR; Ercikan-Abali, EA; Liu-Chen, X; Maley, F; Tong, Y; Zhao, SC | 1 |
| Bertino, JR; Li, WW; Tong, WP | 1 |
| Pazdur, R; Touroutoglou, N | 1 |
| Beale, P; Berry, C; Hanwell, J; Hoskin, P; Judson, I; Maughan, T; Primrose, J; Sutcliffe, F; Walker, M | 1 |
| Cassidy, J; Haites, NE; Johnston, PG; Marsh, S; McLeod, HL; Rooney, PH; Stevenson, DA | 1 |
| Aiba, K; Akazawa, S; Fukuoka, M; Furue, H; Furuse, K; Horikoshi, N; Kanamaru, R; Konishi, T; Kotake, T; Kudoh, S; Kurihara, M; Niitani, H; Ota, K; Sakata, Y; Taguchi, T; Tsukagoshi, S; Wakui, A; Yoshida, S | 1 |
| Millward, MJ; Stewart, JM; Zalcberg, JR | 1 |
| Cunningham, D; Farrugia, DC; Norman, AR | 1 |
| Ciesla, J; Dzik, JM; Hardy, LW; Maley, F; Maley, GF; Montfort, WR; Rode, W; Sotelo-Mundo, RR | 1 |
| Kerr, D; Palmer, M; Seymour, L; Zalcberg, J | 1 |
| Frank, C; Guo, B; Panadero, A; Rustum, YM; Slocum, HK; Wrzosek, C; Yin, MB | 1 |
| Folkes, A; Nutting, C | 1 |
| Byttebier, G; Groener, MG; Rutten, FF; van Hout, BA; van Ineveld, BM | 1 |
| Assaraf, YG; Borst, P; Broxterman, HJ; Hooijberg, JH; Jansen, G; Kool, M; Noordhuis, P; Peters, GJ; Pinedo, HM; Scheper, RJ | 1 |
| Cao, S; McGuire, JJ; Rustum, YM | 1 |
| Bertucci, D; Goh, BC; Mani, S; Ratain, MJ; Vogelzang, NJ; Vokes, EE | 1 |
| Chazal, M; Chéradame, S; Fischel, JL; Formento, P; Milano, G; Renée, N | 1 |
| Collins, O; Dean, NM; DeMoor, J; Ferguson, PJ; Koropatnick, J; Li, CS; Vincent, MD | 1 |
| Azrak, RG; Cao, S; Guo, B; Rustum, YM; Tóth, K; Yin, MB | 1 |
| Abolafio, G; Bearzatto, A; Daidone, MG; De Marco, C; Orlandi, L; Zaffaroni, N | 1 |
| Allegra, CJ; Arbuck, SG; Chen, AP; Cullen, E; Goldspiel, B; Grem, JL; Hamilton, JM; Johnston, PG; Lawrence, D; McAtee, N; Sorensen, JM; Steinberg, SM; Takimoto, CH | 1 |
| Aherne, GW; Barnes, MJ; Calvete, JA; Estlin, EJ; Hardcastle, A; Lunec, J; McGuire, JJ; Newell, DR; Pearson, AD; Taylor, GA | 1 |
| Agostinelli, R; Baldelli, AM; Barni, S; Cascinu, S; Catalano, G; Catalano, V; Frontini, L; Gasparini, G; Giuliodori, L; Labianca, R; Martignoni, G; Mattioli, R; Silva, RR | 1 |
| Adjei, AA | 1 |
| Endo, W; Haridas, K; Hausheer, FH; Matsui, S; Rustum, YM; Seetharamulu, P; Wrzosek, C | 1 |
| Blaese, RM; Candotti, F; Wildner, O | 1 |
| Adamson, PC; Balis, FM; Godwin, KS; McCully, C; Widemann, BC | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Smid, K; Smitskamp-Wilms, E | 1 |
| Creutzig, U; Hählen, K; Janka-Schaub, G; Jansen, G; Kaspers, GJ; Mauritz, R; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ; Willey, JC | 1 |
| Cunningham, D; Norman, A; Parikh, B; Popescu, RA; Ross, PJ | 1 |
| Aiba, K; Horikoshi, N; Kikkawa, N; Kurihara, M; Mitachi, Y; Sakata, Y; Sato, A; Shirouzu, K; Wakui, A | 1 |
| Cunningham, D; Ford, HE | 1 |
| Kerr, D | 1 |
| Bewley, JR; Chen, VJ; Dempsey, JA; Roberts, EF; Schultz, RM; Shih, C | 1 |
| Newell, DR | 1 |
| Bertino, JR; Gorlick, R | 1 |
| Cao, S; Rustum, YM | 1 |
| Danenberg, PV; Malli, H; Swenson, S | 1 |
| Bekradda, M; Cvitkovic, E | 1 |
| Blay, JY; Hermans, C; Judson, I; Rodenhuis, S; Smith, M; van Glabbeke, M; Verweij, J | 1 |
| Armand, JP; Cunningham, D; Kohne, CH; Misset, JL; van Cutsem, E | 1 |
| Avallone, A; Blackie, R; Budillon, A; Caponigro, F; Cartenì, G; Casaretti, R; Catalano, G; Comella, G; Comella, P; De Lucia, L; De Vita, F; Gravina, A; McLeod, H; Morsman, J | 1 |
| Ford, HE; Jackman, AL; Kimbell, R | 1 |
| González Barón, M; Harstrick, A; Schwartz, GK | 1 |
| Armand, JP; Evans, TR; Seymour, L | 1 |
| James, R; Price, P; Valentini, V | 1 |
| Adenis, A; Conroy, T; Paillot, B | 1 |
| Aherne, GW; Benstead, J; Clarke, SJ; Farrugia, DC; Jackman, AL; Pritchard, DM | 1 |
| Ebata, T; Kikkawa, N; Mitachi, Y; Nishiguchi, Y; Nishisho, I; Osanai, H; Sawai, K; Tsutsui, M; Ujiie, S; Wakasugi, H; Wakui, A; Yasutake, K | 1 |
| Danenberg, PV; Lehman, NL | 1 |
| Azrak, RG; Cao, S; Guo, B; Rustum, YM; Tóth, K | 1 |
| Allay, JA; Belt, JA; Patel, DH; Sorrentino, BP | 1 |
| Clarke, SJ; Dalley, D; Davidson, YE; Green, M; Mitchell, PL; Olver, I; Rischin, D; Zalcberg, J | 1 |
| Downes, M; Evans, V; Kay, S; Moore, J; Topham, C; Turner, J; Wardle, J; Young, A | 1 |
| Backus, HH; Kuiper, CM; Peters, GJ; Pinedo, HM; van der Wilt, CL; van Triest, B | 1 |
| Endo, W; Kurihara, M; Matsukawa, M; Nakamachi, M; Sato, A; Shimada, K; Yamazaki, T | 1 |
| De Andrea, M; Gariglio, M; Gribaudo, G; Johnson, LF; Landolfo, S; Lembo, D; Riera, L; Rudge, TL | 1 |
| Kuiper, CM; Peters, GJ; van der Wilt, CL | 1 |
| Akutsu, M; Kano, Y; Suzuki, K; Tsunoda, S; Yazawa, Y | 1 |
| Bianco, AR; Bianco, R; Caputo, R; Ciardiello, F; Damiano, V; De Placido, S; Pomatico, G; Tortora, G | 1 |
| Armand, JP; Bonnay, M; Daniel, C; Ducreux, M; Fandi, A; Fizazi, K; Hill, C; Poterre, M; Ruffié, P; Smith, M; Soria, JC | 1 |
| Avallone, A; Casaretti, R; Catalano, G; Comella, G; Comella, P; De Lucia, L; De Vita, F; Orditura, M; Palmeri, S; Rivellini, F | 1 |
| Strømhaug, A; Warren, DJ | 1 |
| Anthony, DA; Eatock, MM; El-Abassi, M; Evans, TR; Paul, J; Smith, M; Soukop, M; Wilson, P | 1 |
| Aherne, GW; Brunton, L; Jackman, AL; Monaghan, P; Titley, J; Valenti, M; Welsh, SJ | 1 |
| Aherne, GW; Benepal, TS; Cunningham, D; Ford, HE; Gruia, G; Massey, A; Price, T; Rao, S; Ross, PJ; Vernillet, L | 1 |
| Avallone, A; Budillon, A; Caponigro, F; Comella, G; Comella, P; De Rosa, V; Di Gennaro, E; Ionna, F; Manzione, L; Mozzillo, N; Rivellini, F | 1 |
| Armand, J; Bedin, A; Caliandro, R; Cvitkovic, E; Daniel, C; Doubre, H; Fandi, A; Fizazi, K; Le Chevalier, T; Rodier, J; Ruffié, P; Soulié, P; Trandafir, L; Viala, J | 1 |
| Heyes, A; Palmer, MK; Sculpher, M | 1 |
| Fiebiger, W; Raderer, M; Scheithauer, W; Wrba, F | 1 |
| Kobayashi, H; Miyachi, H; Takemura, Y | 1 |
| Angeretti, A; Cavallo, R; Gribaudo, G; Landolfo, S; Lembo, D; Mondo, A; Riera, L | 1 |
| Aherne, GW; Brunton, L; Clarke, SJ; Farrugia, DC; Jackman, AL | 1 |
| Jackson, LE; Leach, MO; Maisey, NR; Ronen, SM; Smith, TA; Titley, JC | 1 |
| Botwood, N; James, R; Price, P; Vernon, C | 1 |
| De Mey, J; Meysman, M; Neyns, B; Schallier, D | 1 |
| Hoff, PM; Pazdur, R; Royce, ME | 1 |
| Mitry, E; Rougier, P | 1 |
| Cassidy, J | 1 |
| Cunningham, D; Sumpter, K | 1 |
| Broderick, L; Greco, WR; Minderman, H; Parsons, JC; Rustum, YM; Slocum, HK; Tóth, K; Winslow, EO | 1 |
| Firby, PS; Hedley, DW; Moore, MJ; Rauchwerger, DR | 1 |
| Avallone, A; Biglietto, M; Cartenì, G; Casaretti, R; Catalano, G; Comella, G; Comella, P; De Lena, M; De Lucia, L; De Vita, F; Farris, A; Ianniello, GP; Leo, SS; Lorusso, V; Mancarella, S | 1 |
| Bower, L; Hickman, JA; Jackman, AL; Potten, CS; Pritchard, DM | 1 |
| Hoff, PM; Padzur, R; Royce, ME | 1 |
| Genestier, L; Izeradjene, K; Revillard, JP | 1 |
| Agrawal, S; Chu, E; Schmitz, JC; Yu, D | 1 |
| De Andrea, M; Gribaudo, G; Johnson, LF; Landolfo, S; Lembo, D; Riera, L | 1 |
| Flieger, D; Hoff, AS; Sauerbruch, T; Schmidt-Wolf, IG | 1 |
| Akutsu, M; Furukawa, Y; Kano, Y; Suzuki, K; Tsunoda, S; Yazawa, Y | 2 |
| Guillot, B; Hellier, I; Topard, D; Ychou, M | 1 |
| Berger, FG; Shaw, D; Spencer, HT | 1 |
| Beale, PJ; Clarke, SJ; Rivory, LP | 1 |
| Bregman, D; Manalo, J; Mani, S | 1 |
| Arvelo, F; Bras-Gonçalves, RA; Coquelle, A; De Pinieux, G; Dutrillaux, B; Formento, JL; Lesuffleur, T; Milano, G; Pandrea, I; Pocard, M; Poirson-Bichat, F; Poupon, MF; Ronco, G; Villa, P | 1 |
| Avallone, A; Caponigro, F; Comella, G; Comella, P; De Rosa, V; Ionna, F; Rivellini, F | 1 |
| Depisch, D; Haider, K; Kornek, GV; Kwasny, W; Penz, M; Raderer, M; Salek, T; Scheithauer, W; Ulrich-Pur, H | 1 |
| Cunningham, D; James, RD | 1 |
| Almog, R; Maley, F; Maley, GF; Van Roey, P; Waddling, CA | 1 |
| Artigue, F; Buffet, C; Cassan, P; Flamenbaum, M; Garcia, V; Kemeny, JL | 1 |
| Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D | 1 |
| Berger, SH; Dunlap, RB; Koli, S; Lebioda, L; Minor, W; Phan, J | 1 |
| Baatenburg de Jong, RJ; Keizer, HJ; ten Bokkel Huinink, D; Tesselaar, ME; Verschuur, HP | 1 |
| Ganser, A; Reinke, F; Schlichting, C; Schöffski, P; van Gennip, AH; van Kuilenburg, AB; Volk, J | 1 |
| Bonmassar, E; Graziani, G; Portarena, I; Tentori, L | 1 |
| Adjei, AA; Ames, MM; Atherton, P; Burch, P; Erlichman, C; Galanis, E; Goldberg, R; Pitot, H; Reid, J; Rubin, J; Safgren, SL; Sloan, J; Witzig, TE | 1 |
| Depisch, D; Kornek, GV; Lang, F; Lenauer, A; Penz, M; Raderer, M; Scheithauer, W; Schneeweiss, B; Schuell, B; Ulrich-Pur, H | 1 |
| Curtin, NJ; Errington, J; Lu, X; Lunec, J; Newell, DR | 1 |
| Louvet, C | 1 |
| Cassidy, J; Marsh, S; McLeod, HL; Wang, W | 1 |
| Avallone, A; Budillon, A; Caponigro, F; Comella, G; Comella, P | 1 |
| Elomaa, I; Joensuu, H; Osterlund, P; Virkkunen, P | 1 |
| Armand, JP; Becouarn, Y; Ducreux, M; Fizazi, K; Seitz, JF | 1 |
| Cellini, N; De Santis, M; Doglietto, GB; Morganti, AG; Ratto, C; Smaniotto, D; Sofo, L; Turriziani, A; Valentini, V | 1 |
| Algazy, K; Giantonio, B; Haller, DG; Hardy, C; Kluijtmans, LA; O'Dwyer, PJ; Redlinger, M; Stevenson, JP; Sun, W; Whitehead, AS | 1 |
| Boyer, J; Ferguson, PR; Harkin, DP; Johnston, PG; Latif, T; Longley, DB; Lynch, M; Maxwell, P | 1 |
| Reimer, P; Rückle-Lanz, H | 1 |
| Brugger, S; Depisch, D; Fiebiger, W; Gedlicka, C; Kornek, GV; Lang, F; Lenauer, A; Raderer, M; Scheithauer, W; Schneeweiss, B; Schüll, B; Ulrich-Pur, H | 1 |
| Backus, HH; Kuiper, CM; Peters, GJ; Pinedo, HM; van der Wilt, CL; van Groeningen, CJ; Wouters, D | 1 |
| Calvert, AH; Cunningham, D; Farrugia, DC; Ford, HE; Hill, ME; Jackman, AL; Judson, IR; Mitchell, F; Rees, C | 1 |
| Reutova, EV | 1 |
| Fizazi, K; John, WJ; Vogelzang, NJ | 1 |
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| Chernobrovkin, A; Marin-Vicente, C; Visa, N; Zubarev, RA | 1 |
| Cheung, WY; Doll, C; Goodwin, R; Heng, DY; Jiang, DM; Kumar, A; MacLean, A; Mercer, J; Monzon, J; Powell, E; Price-Hiller, J; Raissouni, S; Tang, PA; Vickers, MM | 1 |
| Aloj, L; Avallone, A; Bianco, F; Botti, G; Budillon, A; Caracò, C; Comella, P; Delrio, P; Granata, V; Iaffaioli, VR; Leone, A; Marone, P; Muto, P; Pecori, B; Petrillo, A; Romano, C; Romano, G; Tatangelo, F | 1 |
| Sun, J; Zhan, C; Zhang, Y; Zhao, H; Zhao, L | 1 |
| Chen, C; Cheng, L; Fan, L; Hu, T; Lu, J; Lu, X; Ma, Y; Ni, B; Ou, S; Qi, F; Yi, X; Yu, L; Zhang, C; Zhao, C; Zheng, Z | 1 |
| Arcelli, A; Ardizzoni, A; Caravatta, L; Cellini, F; Cilla, S; Cuicchi, D; Deodato, F; DI Fabio, F; Farioli, A; Frezza, G; Fuccio, L; Gambacorta, MA; Giaccherini, L; Guido, A; Macchia, G; Morganti, AG; Picardi, V; Poggioli, G; Valentini, V | 1 |
| Choi, YM; Lee, JY; Park, YW; Yeo, HK | 1 |
| Chen, H; Gao, S; Guo, JH; Li, XT; Wang, XD; Zhang, HY; Zhang, PJ; Zhu, X | 1 |
| Kanamitsu, K; Kusuhara, H; Schuetz, JD; Sugiyama, Y; Takeuchi, K | 1 |
| Cai, G; Cai, S; Chen, Y; Li, Y; Liang, X; Liu, J; Meng, X; Qi, Y; Qiu, C; Xu, Y; Zheng, H | 1 |
| Chen, D; Jansson, A; Larsson, A; Nordlund, P; Sim, D | 1 |
| Cherubini, C; Drudi, F; Fantini, M; Lazzari-Agli, L; Papi, M; Sartori, S; Tamburini, E; Tassinari, D | 1 |
| Haglund, C; Hermunen, K; Lantto, E; Österlund, P; Poussa, T | 1 |
| Berger, SH; Chapman, JM; El Magdoub, HM; El-Mesallamy, HO; Hamdy, NM; Hammad, LN; Schaalan, MF | 1 |
| Aglietta, M; Bonzano, A; Cagnazzo, C; Depetris, I; Filippi, R; Leone, F; Marino, D | 1 |
| Andreotti, CEL; Bueno, PSA; de Lima, DA; de Moraes, ALS; de Paula Reis, M; Gasparotto Junior, A; Gonçalves, DD; Lourenço, ELB; Navarro, IT; Pauli, KB; Seixas, FAV | 1 |
| Qian, HL; Xu, S; Zhu, LZ | 1 |
| Liu, H; Shi, L; Tong, G; Wang, D; Wu, J; Xu, L; Yan, D; Yu, C; Zhu, X | 1 |
| Cao, H; Ding, W; Li, C; Li, W; Liu, R; Lu, L; Shao, G; Song, J; Wang, J; Xiang, H; Yang, J; Yang, Z | 1 |
| Chi, Y; Jiang, ZC | 1 |
| He, XH; Huang, HZ; Li, GD; Li, WT; Wang, GZ; Wang, Y; Wang, YH; Wei, N; Xu, LC; Zhang, B | 1 |
| Braconi, C; Chau, I; Cunningham, D; Forster, M; Gerlinger, M; Kalaitzaki, E; Khan, K; Rane, JK; Rao, S; Starling, N; Valeri, N; Watkins, D | 1 |
| Bi, F; Cao, D; Chen, Y; Cheng, K; Gou, HF; Li, Q; Li, ZP; Liu, JY; Luo, DY; Qiu, M; Shen, YL; Wang, X; Wu, J; Yang, Y; Yi, C | 1 |
| Cao, J; Cheng, M; Wang, W; Wu, Q; Yuan, Z; Zhang, Y | 1 |
| Li, X; Zhang, X; Zheng, N; Zhu, L | 1 |
| Landry, MR; Rosch, JG; Sun, C; Thomas, CR | 1 |
| Aul, R; Hill, M; Howlett, S; Pinato, DJ | 1 |
| Chen, Y; Gubat, JA; Jia, Q; Li, Y; Liu, M; Min, L; Sun, C; Wang, X; Yang, J; Zhang, X; Zhu, C | 1 |
| Che, Y; Jiang, C; Li, A; Li, J; Qiu, X; Shen, Z; Wang, Z; Wu, T; Zhang, M; Zhou, H; Zhu, X | 1 |
| Cai, G; Gong, Q; Liang, X; Liu, J; Song, C; Wang, R; Wang, X | 1 |
| Gao, H; Hao, H; Li, S; Qi, C; Zhang, L; Zong, H | 1 |
| Kadomatsu, K; Kishida, S; Kiyonari, S; Sakai, R; Tsubota, S; Yamashita, K | 1 |
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| Costi, MP; D'Arca, D; Ferrari, S; Gozzi, G; Lauriola, A; Leo, E; Losi, L; Maretti, E; Marverti, G; Pacifico, S; Ponterini, G; Sacchetti, F; Severi, L | 1 |
| Chambers, C; Giani, J; Sawyer, MB | 1 |
| Bian, X; Guo, W; He, X; Huang, S; Jiang, N; Jiang, X; Li, F; Liu, J; Song, D; Sun, X; Wang, B; Wang, F; Wu, J; Yan, P; Yin, H; Yin, L; Zhang, F; Zhou, C; Zhou, H | 1 |
| Batra, A; Cheung, WY; Hannouf, MB; Rigo, R | 1 |
| Cai, B; Di, X; Ge, X; Liu, Z; Sun, X; Xia, X | 1 |
| Chen, Z; Guo, W; Huang, M; Li, W; Qiu, L; Wang, C; Wang, Y; Yang, Y; Zhang, W; Zhang, X; Zhang, Z; Zhao, X; Zhu, X | 1 |
| Christenson, ES; Cui, J; DePasquale, M; Egleston, M; Gizzi, A; Orris, B; Park, BH; Seamon, KJ; Stivers, JT | 1 |
| Bi, F; Cao, D; Chen, Y; Cheng, K; Gou, HF; Li, Q; Li, ZP; Liu, JY; Luo, DY; Qiu, M; Shen, YL; Wang, X; Yang, Y; Zhou, YW | 1 |
| Huang, G; Li, W; Liu, H; Luo, S; Lv, X; Wang, Y; Zhou, D | 1 |
| Barat, C; Breton, Y; Desrosiers, V; Ouellet, M; Tremblay, MJ | 1 |
| Artru, P; Auclin, E; Basile, D; Coutzac, C; Dior, M; Dubreuil, O; Faroux, R; Gallois, C; Hafliger, E; Hautefeuille, V; Locher, C; Palmieri, LJ; Pellat, A; Pernot, S; Perret, A; Randrian, V; Taieb, J; Turpin, A | 1 |
| Liu, L; Lu, D; Lu, E; Lv, W; Sha, X; Tie, J | 1 |
| Chen, Y; Cui, Z; Ding, M; Fang, H; Li, H; Lin, Y; Ma, C; Niu, Q; Sun, H; Sun, S; Wang, S; Xiao, N; Xu, Y; Zhou, BS | 1 |
| Bi, Y; Han, X; Jiao, D; Ren, J; Wang, Y | 1 |
| Chen, X; Dai, J; Hu, C; Lin, X; Yu, J | 1 |
| Bi, Y; Han, X; Jiao, D; Ren, J | 1 |
| Charushin, VN; Kovalev, IS; Majee, A; Santra, S; Varaksin, MV; Zyryanov, GV | 1 |
93 review(s) available for quinazolines and raltitrexed
| Article | Year |
|---|---|
Antifolates: the next generation.
Topics: Aminopterin; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Drug Evaluation; Folic Acid Antagonists; Forecasting; Humans; Neoplasms; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 1992 |
Novel chemotherapeutic agents in clinical development.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Humans; Mitomycin; Mitomycins; Paclitaxel; Pyrazoles; Quinazolines; Thiophenes; Topotecan | 1991 |
The role of the reduced-folate carrier and metabolism to intracellular polyglutamates for the activity of ICI D1694.
Topics: Animals; Carrier Proteins; Cells, Cultured; Clinical Trials, Phase I as Topic; Folate Receptors, GPI-Anchored; Humans; Oxidation-Reduction; Polyglutamic Acid; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase | 1993 |
Initiatives with platinum- and quinazoline-based antitumor molecules--Fourteenth Bruce F. Cain Memorial Award Lecture.
Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Resistance; Female; Humans; Leukemia L1210; Mice; Neoplasm Transplantation; Organoplatinum Compounds; Ovarian Neoplasms; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 1995 |
Thymidylate synthase inhibition, a dead end?
Topics: Antidotes; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Quinazolines; Thiophenes; Thymidylate Synthase | 1995 |
Folate-based thymidylate synthase inhibitors as anticancer drugs.
Topics: Antineoplastic Agents; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 1995 |
Role of chemotherapy for advanced colorectal cancer: new opportunities.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 1996 |
[Recent advance in chemotherapy for advanced colorectal cancer].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Quinazolines; Remission Induction; Thiophenes; Thymidylate Synthase | 1996 |
New anticancer agents in clinical development.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Gemcitabine; Humans; Neoplasms; Polysaccharides, Bacterial; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidylate Synthase; Uracil | 1995 |
The development of new chemotherapeutic agents.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Deoxycytidine; Gemcitabine; Glutamates; Guanine; Humans; Irinotecan; Neoplasms; Pemetrexed; Quinazolines; Thiophenes; Trimetrexate | 1996 |
New systemic drugs in the treatment of gastrointestinal cancer.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials as Topic; Docetaxel; Gastrointestinal Neoplasms; Humans; Irinotecan; Paclitaxel; Quinazolines; Taxoids; Thiophenes; Thymidylate Synthase | 1996 |
New antifolates in clinical development.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Drugs, Investigational; Folic Acid Antagonists; Humans; Neoplasms; Pyrimidines; Quinazolines; Thiophenes; Trimetrexate | 1995 |
Raltitrexed in colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Humans; Quinazolines; Thiophenes | 1996 |
Tomudex (ZD1694): from concept to care, a programme in rational drug discovery.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Design; Drugs, Investigational; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; DNA Damage; DNA, Neoplasm; Drug Resistance; Fluorouracil; Folic Acid Antagonists; Forecasting; Humans; Prodrugs; Quinazolines; Thiophenes; Thymidylate Synthase | 1997 |
New anticancer drugs in Europe.
Topics: Aminopterin; Anthraquinones; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Aziridines; Bridged-Ring Compounds; Bryostatins; Camptothecin; Dacarbazine; Deoxycytidine; Distamycins; Doxorubicin; Europe; Gemcitabine; Humans; Indolequinones; Indoles; Irinotecan; Lactones; Macrolides; Nitrogen Mustard Compounds; Nitrosourea Compounds; Pyrazoles; Quinazolines; Taxoids; Temozolomide; Thiophenes; Vinca Alkaloids | 1997 |
Colorectal cancer--is there an alternative to 5-FU?
Topics: Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Leucovorin; Quinazolines; Thiophenes; Thymidylate Synthase | 1997 |
Chemotherapy for the treatment of patients with metastatic colorectal cancer: an overview.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Quinazolines; Thiophenes; Thymidylate Synthase; Trimetrexate | 1997 |
Talking 'Tomudex': introduction.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Humans; Quinazolines; Thiophenes | 1997 |
Clinical efficacy of 'Tomudex' (raltitrexed) in advanced colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Quinazolines; Thiophenes | 1997 |
Overview of the tolerability of 'Tomudex' (raltitrexed): collective clinical experience in advanced colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Colorectal Neoplasms; Humans; Quinazolines; Thiophenes | 1997 |
The costs of managing advanced colorectal cancer: a broad perspective.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Humans; Quinazolines; Thiophenes | 1997 |
Future developments with 'Tomudex' (raltitrexed).
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Quinazolines; Thiophenes | 1997 |
'Tomudex' (raltitrexed) development: preclinical, phase I and II studies.
Topics: Antimetabolites, Antineoplastic; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Humans; Quinazolines; Thiophenes | 1997 |
Folate and antifolate pharmacology.
Topics: Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Trimetrexate | 1997 |
Antifolates in clinical development.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase | 1997 |
Continuing the fight against advanced colorectal cancer: new and future treatment options.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors | 1998 |
Raltitrexed. A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Quinazolines; Thiophenes; Thymidylate Synthase | 1998 |
Tumor resistance to antimetabolites.
Topics: Antimetabolites, Antineoplastic; Cell Cycle Proteins; Deoxycytidine; DNA Damage; DNA, Neoplasm; Drug Resistance, Neoplasm; Fluorouracil; Gemcitabine; Gene Amplification; Humans; Methotrexate; Mutation; Neoplasms; Quinazolines; Thiophenes | 1998 |
Mature results from three large controlled studies with raltitrexed ('Tomudex').
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Quinazolines; Thiophenes; Thymidylate Synthase | 1998 |
New developments in cancer treatment with the novel thymidylate synthase inhibitor raltitrexed ('Tomudex').
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Colorectal Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Humans; Quinazolines; Thiophenes; Thymidylate Synthase | 1998 |
New drugs in the treatment of colorectal carcinoma.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Topotecan; Trimetrexate; Uracil | 1998 |
[Drug clinics. How I treat. II. Therapeutic approaches to metastatic colorectal cancer].
Topics: Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Enzyme Inhibitors; Fluorouracil; Hospitalization; Humans; Irinotecan; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Quality of Life; Quinazolines; Rectal Neoplasms; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors | 1998 |
Thymidylate synthase inhibitors.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Enzyme Inhibitors; Genes, p53; Humans; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer.
Topics: Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Glutamates; Guanine; Humans; Pemetrexed; Platinum Compounds; Pyridines; Quinazolines; Tegafur; Thiophenes; Uracil | 1999 |
Clinical pharmacokinetics of antitumor antifolates.
Topics: Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase | 1999 |
Drug resistance in colon cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Colorectal Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Gene Expression; Humans; Quinazolines; Thiophenes; Thymidylate Synthase | 1999 |
New drugs in therapy of colorectal cancer: preclinical studies.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Oxidoreductases; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidine Phosphorylase; Thymidylate Synthase; Uracil | 1999 |
Thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 1999 |
Oxaliplatin: a new therapeutic option in colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil | 1999 |
Clinical advances with topoisomerase I inhibitors in gastrointestinal malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Docetaxel; Enzyme Inhibitors; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Platinum; Quinazolines; Taxoids; Thiophenes; Topoisomerase I Inhibitors | 1999 |
Raltitrexed (Tomudex) in combination treatment for colorectal cancer: new perspectives.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 1999 |
Combination of raltitrexed with other cytotoxic agents: rationale and preclinical observations.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Quinazolines; Thiophenes; Tumor Cells, Cultured | 1999 |
[New drugs in gastrointestinal oncology. Current status and future directions].
Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gemcitabine; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Quinazolines; Taxoids; Tegafur; Thiophenes; Vinblastine; Vinorelbine | 1999 |
Combination raltitrexed (Tomudex(R))-oxaliplatin: a step forward in the struggle against mesothelioma? The Institut Gustave Roussy experience with chemotherapy and chemo-immunotherapy in mesothelioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Female; Humans; Immunotherapy; Interferon-alpha; Interleukin-2; Male; Mesothelioma; Middle Aged; Mitomycin; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes | 2000 |
Progress in colorectal cancer chemotherapy: how far have we come, how far to go?
Topics: Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Immunotherapy; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes | 2000 |
Current treatment options for advanced colorectal cancer.
Topics: Antineoplastic Agents; Camptothecin; Clinical Trials as Topic; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2000 |
Thymidylate synthase inhibitors in colorectal cancer.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 2000 |
Combination chemotherapy and colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Mitomycin; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2000 |
Novel chemotherapy agents for colorectal cancer: oral fluoropyrimidines, oxaliplatin, and raltitrexed.
Topics: Administration, Oral; Antineoplastic Agents; Colorectal Neoplasms; Humans; Organoplatinum Compounds; Oxaliplatin; Pyrimidines; Quinazolines; Thiophenes | 1999 |
Clinical and preclinical pharmacokinetics of raltitrexed.
Topics: Adult; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Child; Clinical Trials as Topic; Drug Interactions; Enzyme Inhibitors; Half-Life; Humans; Metabolic Clearance Rate; Neoplasms; Protein Binding; Quinazolines; Thiophenes; Thymidylate Synthase | 2000 |
Novel combinations with oxaliplatin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Gemcitabine; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes | 2000 |
Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Pyrimidines; Quinazolines; Tegafur; Thiophenes; Uracil | 2001 |
[New chemotherapies for colorectal cancer treatment].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2001 |
Raltitrexed/5-fluorouracil-based combination chemotherapy regimens in anticancer therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Neoplasm Metastasis; Neoplasms; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Rectal Neoplasms; Thiophenes | 2001 |
[Oxaliplatin in combination with non fluoropyrimidine drugs in colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Dose-Response Relationship, Drug; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2001 |
[New therapeutic options in chemotherapy of advanced colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Carcinoma; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil | 2001 |
The emerging role of antifolates in the treatment of malignant pleural mesothelioma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Folic Acid Antagonists; Glutamates; Guanine; Humans; Mesothelioma; Organoplatinum Compounds; Oxaliplatin; Pemetrexed; Pleural Neoplasms; Quinazolines; Thiophenes | 2002 |
[The new chemotherapy of colorectal cancers].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Combined Modality Therapy; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Organoplatinum Compounds; Oxaliplatin; Postoperative Care; Prodrugs; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Time Factors | 2002 |
Efficacy, tolerability and management of raltitrexed (Tomudex) monotherapy in patients with advanced colorectal cancer. a review of phase II/III trials.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Antimetabolites, Antineoplastic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Diarrhea; Female; Humans; Leukopenia; Male; Middle Aged; Nausea; Neutropenia; Pain; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis; Thiophenes; Vomiting | 2002 |
New therapies, new directions: advances in the systemic treatment of metastatic colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Forecasting; Humans; Irinotecan; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Trimetrexate; Uracil | 2001 |
A rapid and systematic review of the evidence for the clinical effectiveness and cost-effectiveness of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Cost-Benefit Analysis; Drug Costs; England; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quality of Life; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis; Thiophenes; Treatment Outcome; Wales | 2001 |
Raltitrexed: current clinical status and future directions.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Fluorouracil; Humans; Mesothelioma; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2002 |
A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours.
Topics: Antineoplastic Agents; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Folic Acid Antagonists; Gene Expression; Humans; Ovarian Neoplasms; Peptide Synthases; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Advances in the treatment of metastatic colorectal cancer.
Topics: Administration, Oral; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cancer Vaccines; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Prodrugs; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Uracil | 2001 |
Emerging insights into the biology and therapy of malignant mesothelioma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Folic Acid Antagonists; Gemcitabine; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 2002 |
[Economic assessment of adjuvant and palliative chemotherapy in colorectal cancer: a review].
Topics: Antineoplastic Agents; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Fluorouracil; France; Humans; Irinotecan; Leucovorin; Levamisole; Palliative Care; Quality-Adjusted Life Years; Quinazolines; Thiophenes | 2003 |
Palliative treatment of patients with colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Camptothecin; Colorectal Neoplasms; Disease Progression; Enzyme Inhibitors; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Palliative Care; Quinazolines; Survival Analysis; Tegafur; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Treatment Outcome; Uracil | 2003 |
[Chemotherapy for colorectal cancers].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Prognosis; Quality of Life; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Time Factors | 2003 |
Irinotecan in metastatic colorectal cancer: dose intensification and combination with new agents, including biological response modifiers.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cetuximab; Clinical Trials as Topic; Colorectal Neoplasms; Cyclooxygenase 2; Deoxycytidine; Drug Administration Schedule; Enzyme Inhibitors; Flavonoids; Fluorouracil; Humans; Immunologic Factors; Irinotecan; Isoenzymes; Leucovorin; Membrane Proteins; Organoplatinum Compounds; Oxaliplatin; Piperidines; Prostaglandin-Endoperoxide Synthases; Quinazolines; Thiophenes; Treatment Outcome | 2003 |
Thymidylate synthase inhibitors as anticancer agents: from bench to bedside.
Topics: Antineoplastic Agents; Enzyme Inhibitors; Humans; Indoles; Isoindoles; Neoplasms; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Thymidylate Synthase | 2003 |
Review article: colorectal cancer chemotherapy.
Topics: Antineoplastic Agents; Camptothecin; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colorectal Neoplasms; Drug Design; Floxuridine; Fluorouracil; Forecasting; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Organoplatinum Compounds; Oxaliplatin; Pyrimidines; Quinazolines; Thiophenes | 2003 |
New developments in systemic chemotherapy in advanced colorectal cancer.
Topics: Administration, Oral; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil | 2003 |
Chemotherapy options and new advances in malignant pleural mesothelioma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Gemcitabine; Glutamates; Guanine; Humans; Mesothelioma; Palliative Care; Pemetrexed; Pleural Neoplasms; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes | 2005 |
The use of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Practice Guidelines as Topic; Quinazolines; Thiophenes; United Kingdom | 2005 |
Irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2006 |
Systemic chemotherapy in the management of malignant peritoneal mesothelioma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Gemcitabine; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Peritoneal Neoplasms; Quinazolines; Thiophenes; Vinblastine; Vinorelbine | 2006 |
The use of chemotherapy in patients with advanced malignant pleural mesothelioma: a systematic review and practice guideline.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Female; Glutamates; Guanine; Humans; Male; Maximum Tolerated Dose; Mesothelioma; Neoplasm Invasiveness; Patient Selection; Pemetrexed; Pleural Neoplasms; Practice Guidelines as Topic; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis; Thiophenes; Treatment Outcome | 2006 |
The use of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer: systematic review and economic evaluation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Cost-Benefit Analysis; Drug Costs; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Treatment Outcome | 2008 |
[Chemotherapy of malignant pleural mesothelioma: have we made any progress?].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Glutamates; Guanine; Humans; Mesothelioma; Neoplasm Staging; Pemetrexed; Pleural Neoplasms; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Retreatment; Thiophenes | 2008 |
C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Pharmacogenetics; Polymorphism, Genetic; Quinazolines; Thiophenes; Treatment Outcome | 2009 |
Future developments in the management of malignant pleural mesothelioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cisplatin; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Diagnostic Imaging; Disease Management; Drug Delivery Systems; Forecasting; Glutamates; Guanine; Humans; Mesothelioma; Mice; Multicenter Studies as Topic; Neoplasm Proteins; Neoplasm Staging; Pemetrexed; Pleural Neoplasms; Quinazolines; Radiotherapy, Intensity-Modulated; Randomized Controlled Trials as Topic; Thiophenes; Thoracic Surgical Procedures; Vinblastine; Vinorelbine | 2009 |
Raltitrexed: optimism and reality.
Topics: Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Humans; Quinazolines; Thiophenes; Thymidylate Synthase; Tissue Distribution | 2009 |
Raltitrexed in mesothelioma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Humans; Mesothelioma; Pleural Neoplasms; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Thymidylate Synthase; Treatment Outcome | 2011 |
Systemic treatment of malignant pleural mesothelioma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Pleura; Pleural Neoplasms; Quinazolines; Thiophenes; Treatment Outcome | 2012 |
New oxaliplatin-based combinations in the treatment of colorectal cancer.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Boronic Acids; Bortezomib; Camptothecin; Capecitabine; Cetuximab; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Gefitinib; Humans; Irinotecan; Mitomycin; Organoplatinum Compounds; Oxaliplatin; Pyrazines; Quinazolines; Thiophenes | 2003 |
Use of raltitrexed as an alternative to 5-fluorouracil and capecitabine in cancer patients with cardiac history.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Heart Diseases; Humans; Neoplasms; Quinazolines; Retrospective Studies; Thiophenes | 2013 |
Targeting thymidylate synthase in colorectal cancer: critical re-evaluation and emerging therapeutic role of raltitrexed.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Fluorouracil; Humans; Quinazolines; Thiophenes; Thymidylate Synthase | 2014 |
Raltitrexed-based chemotherapy for advanced colorectal cancer.
Topics: Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Chemical and Drug Induced Liver Injury; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Mucositis; Nausea; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Randomized Controlled Trials as Topic; Stomatitis; Thiophenes; Vomiting | 2014 |
A systematic review of raltitrexed-based first-line chemotherapy in advanced colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cardiotoxicity; Colorectal Neoplasms; Diarrhea; Humans; Irinotecan; Liver; Neoplasm Metastasis; Neutropenia; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2014 |
Antimetabolites in the treatment of advanced pleural mesothelioma: a network meta-analysis of randomized clinical trials.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Network Meta-Analysis; Pemetrexed; Pleural Neoplasms; Quinazolines; Thiophenes; Treatment Outcome | 2017 |
Fluoropyrimidine-induced cardiotoxicity.
Topics: Acetates; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Drug Combinations; Fluorouracil; Humans; Neoplasms; Pyrimidines; Pyrrolidines; Quinazolines; Thiophenes; Thymine; Trifluridine; Uracil; Uridine | 2018 |
Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities.
Topics: Antimetabolites; Folic Acid; Folic Acid Antagonists; Methotrexate; Pemetrexed; Quinazolines; Thiophenes | 2022 |
126 trial(s) available for quinazolines and raltitrexed
| Article | Year |
|---|---|
The toxicity of ICI D1694 in man and mouse.
Topics: Adult; Aged; Animals; Drug Administration Schedule; Female; Folic Acid Antagonists; Humans; Infusions, Intravenous; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Middle Aged; Neoplasms; Quinazolines; Thiophenes | 1993 |
'Tomudex' (ZD1694): results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia. The 'Tomudex' Colorectal Cancer Study Group.
Topics: Adult; Aged; Aged, 80 and over; Antidotes; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up Studies; Humans; Length of Stay; Leucovorin; Leukopenia; Male; Middle Aged; Quality of Life; Quinazolines; Stomatitis; Survival Rate; Thiophenes | 1995 |
ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. Tomudex Colorectal Study Group.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Progression; Female; Humans; Male; Middle Aged; Quinazolines; Remission Induction; Survival Analysis; Thiophenes; Thymidylate Synthase | 1996 |
Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
A phase II study of Tomudex in relapsed epithelial ovarian cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Ovarian Neoplasms; Quinazolines; Remission Induction; Thiophenes | 1995 |
A phase II study in advanced breast cancer: ZD1694 ('Tomudex') a novel direct and specific thymidylate synthase inhibitor.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Middle Aged; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
'Tomudex' (ZD1694): a novel thymidylate synthase inhibitor with clinical antitumour activity in a range of solid tumours. 'Tomudex' International Study Group.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Quinazolines; Survival Rate; Thiophenes; Thymidylate Synthase; Treatment Outcome | 1996 |
Phase II trial of ZD1694 (Tomudex) in patients with advanced pancreatic cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Pancreatic Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
Phase II study of ZD1694 in patients with advanced gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Alanine Transaminase; Antimetabolites, Antineoplastic; Aspartate Aminotransferases; Asthenia; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Leukopenia; Male; Middle Aged; Mucous Membrane; Nausea; Neoplasm Staging; Quinazolines; Remission Induction; Stomach Neoplasms; Thiophenes; Thrombocytopenia; Thymidylate Synthase; Vomiting | 1996 |
Final results of a randomised trial comparing 'Tomudex' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. "Tomudex" Colorectal Cancer Study Group.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Longitudinal Studies; Male; Middle Aged; Quinazolines; Thiophenes | 1996 |
Phase II trial of raltitrexed ('Tomudex') in advanced small-cell lung cancer.
Topics: Adult; Aged; Carcinoma, Small Cell; Disease Progression; Enzyme Inhibitors; Female; Humans; Lung Neoplasms; Male; Middle Aged; Quinazolines; Survival Rate; Thiophenes; Thymidylate Synthase; Treatment Outcome | 1997 |
A phase II study of raltitrexed ('Tomudex') in patients with hepatocellular carcinoma.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Female; Folic Acid Antagonists; Humans; Liver Neoplasms; Male; Middle Aged; Quinazolines; Thiophenes | 1997 |
Measuring quality of life: impact of chemotherapy for advanced colorectal cancer. Experience from two recent large phase III trials.
Topics: Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Quality of Life; Quinazolines; Surveys and Questionnaires; Thiophenes; Thymidylate Synthase | 1998 |
Tomudex (ZD1694, NSC 639186) in platinum-pretreated recurrent epithelial ovarian cancer: a phase II study by the Gynecologic Oncology Group.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Enzyme Inhibitors; Female; Humans; Middle Aged; Neoplasm Metastasis; Ovarian Neoplasms; Platinum Compounds; Quinazolines; Thiophenes; Thymidylate Synthase | 1998 |
Metabolism, excretion and pharmacokinetics of a single dose of [14C]-raltitrexed in cancer patients.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Carbon Radioisotopes; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Neoplasms; Quinazolines; Radiopharmaceuticals; Thiophenes; Thymidylate Synthase | 1998 |
Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Quality of Life; Quinazolines; Survival Analysis; Thiophenes | 1998 |
Effects of impaired renal function on the pharmacokinetics of raltitrexed (Tomudex ZD1694).
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Drug Administration Schedule; Female; Humans; Kidney; Male; Middle Aged; Neoplasms; Quinazolines; Thiophenes | 1998 |
[Phase I study of raltitrexed (ZD-1694)].
Topics: Adult; Aged; Alanine Transaminase; Anorexia; Antimetabolites, Antineoplastic; Aspartate Aminotransferases; Colonic Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase | 1998 |
Single agent infusional 5-fluorouracil is not effective second-line therapy after raltitrexed (Tomudex) in advanced colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Prospective Studies; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome | 1998 |
Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number. Tomudex International Study Group.
Topics: Adult; Age Factors; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Hematologic Diseases; Humans; Leucovorin; Male; Middle Aged; Quinazolines; Sex Factors; Thiophenes | 1998 |
An economic evaluation of Tomudex (raltitrexed) and 5-fluorouracil plus leucovorin in advanced colorectal cancer.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Cost-Benefit Analysis; Costs and Cost Analysis; Fluorouracil; Health Care Costs; Humans; Leucovorin; Netherlands; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis; Thiophenes | 1999 |
A Phase I study of raltitrexed and paclitaxel given every 3 weeks to patients with solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Drug Administration Schedule; Drug Evaluation; Female; Humans; Lymphoma; Male; Middle Aged; Neoplasms; Neutropenia; Paclitaxel; Quinazolines; Thiophenes | 1999 |
A Phase I study of raltitrexed, an antifolate thymidylate synthase inhibitor, in adult patients with advanced solid tumors.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Folic Acid Antagonists; Humans; Male; Middle Aged; Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase | 1999 |
A phase II study of Tomudex alternated with methotrexate, 5-fluorouracil, leucovorin in first-line chemotherapy of metastatic colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Prognosis; Quinazolines; Survival Rate; Thiophenes; Treatment Outcome | 1999 |
Phase II study of raltitrexed (Tomudex) in chemotherapy-pretreated patients with advanced colorectal cancer. Tomudex Cooperative Study Group.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Treatment Outcome | 1999 |
Phase II study of raltitrexed ('Tomudex') for patients with advanced soft tissue sarcomas refractory to doxorubicin-containing regimens.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Neutropenia; Quinazolines; Sarcoma; Soft Tissue Neoplasms; Thiophenes; Thrombocytopenia; Treatment Outcome | 1999 |
Phase I and pharmacokinetic study of tomudex combined with 5-fluorouracil plus levofolinic acid in advanced head and neck cancer and colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Male; Middle Aged; Quinazolines; Thiophenes | 1999 |
Raltitrexed (Tomudex) in combination with 5-fluorouracil for the treatment of patients with advanced colorectal cancer: preliminary results from phase I clinical trials.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Male; Middle Aged; Quinazolines; Thiophenes; Treatment Outcome | 1999 |
Raltitrexed (Tomudex) in combination with platinum-based agents and/or anthracyclines: preliminary results of phase I clinical trials.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colorectal Neoplasms; Digestive System Neoplasms; Doxorubicin; Drug Administration Schedule; Epirubicin; Female; Humans; Mesothelioma; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Treatment Outcome | 1999 |
Raltitrexed (Tomudex) concomitant with radiotherapy as adjuvant treatment for patients with rectal cancer: preliminary results of phase I studies.
Topics: Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Quinazolines; Radiotherapy, Adjuvant; Rectal Neoplasms; Thiophenes; Treatment Outcome | 1999 |
[A late phase II study of raltitrexed (ZD 1694) in chemotherapy-naive patients with advanced colorectal cancer].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Leukopenia; Male; Middle Aged; Quinazolines; Rectal Neoplasms; Thiophenes; Thymidylate Synthase | 2000 |
Open label, multi-centre phase II study of raltitrexed ('Tomudex') in patients with inoperable squamous-cell carcinoma of head and neck.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Palliative Care; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome | 2000 |
A patient preference study comparing raltitrexed ('Tomudex') and bolus or infusional 5-fluorouracil regimens in advanced colorectal cancer: influence of side-effects and administration attributes.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Patient Satisfaction; Pulse Therapy, Drug; Quinazolines; Thiophenes | 1999 |
Phase I, dose-finding, and pharmacokinetic study of raltitrexed combined with oxaliplatin in patients with advanced cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Neoplasms; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Treatment Outcome | 2000 |
Oxaliplatin and raltitrexed combined with leucovorin-modulated 5-fluorouracil i.v. bolus every two weeks: a dose finding study in advanced previously treated colorectal carcinoma. Southern Italy Cooperative Oncology Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Rectal Neoplasms; Thiophenes; Treatment Outcome | 2000 |
A dose-finding study of raltitrexed (tomudex) with cisplatin and epirubicin in advanced gastro-oesophageal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Epirubicin; Esophageal Neoplasms; Female; Humans; Male; Middle Aged; Quinazolines; Stomach Neoplasms; Thiophenes; Treatment Outcome | 2000 |
Phase I study of irinotecan and raltitrexed in patients with advanced gastrointestinal tract adenocarcinoma.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; Gastrointestinal Neoplasms; Humans; Irinotecan; Male; Middle Aged; Quinazolines; Survival Rate; Thiophenes; Treatment Outcome | 2000 |
Cisplatin, raltitrexed, levofolinic acid and 5-fluorouracil in locally advanced or metastatic squamous cell carcinoma of the head and neck: a phase I-II trial of the Southern Italy Cooperative Oncology Group (SICOG).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Dose-Response Relationship, Drug; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Male; Middle Aged; Neutropenia; Quinazolines; Thiophenes; Treatment Outcome | 2000 |
Costs incurred by patients undergoing advanced colorectal cancer therapy. A comparison of raltitrexed and fluorouracil plus folinic acid.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Cost of Illness; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Prospective Studies; Quinazolines; Surveys and Questionnaires; Thiophenes; Time Factors; Travel; United Kingdom | 2000 |
Raltitrexed ('Tomudex') and radiotherapy can be combined as postoperative treatment for rectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Neutropenia; Pneumonia; Quinazolines; Radiotherapy, Adjuvant; Rectal Neoplasms; Thiophenes; Treatment Outcome | 2000 |
Biweekly irinotecan or raltitrexed plus 6S-leucovorin and bolus 5-fluorouracil in advanced colorectal carcinoma: a Southern Italy Cooperative Oncology Group phase II-III randomized trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Quality of Life; Quinazolines; Thiophenes; Treatment Failure | 2000 |
Phase I study of mitoxantrone, raltitrexed, levofolinic acid and 5-fluorouracil in advanced solid tumours.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Male; Middle Aged; Mitoxantrone; Neoplasms; Quinazolines; Thiophenes | 2001 |
Oxaliplatin plus raltitrexed in patients with advanced colorectal carcinoma: results of a Phase I-II trial.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colorectal Neoplasms; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Quinazolines; Survival Rate; Thiophenes; Thymidylate Synthase | 2001 |
A phase I study of a fixed dose of cisplatin with increasing doses of raltitrexed (Tomudex) in the treatment of patients with locally advanced or metastatic squamous cell carcinoma of the head and neck.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Dose-Response Relationship, Drug; Female; Head and Neck Neoplasms; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neutropenia; Quinazolines; Thiophenes; Treatment Outcome | 2001 |
Phase I trial of sequential administration of raltitrexed (Tomudex) and 5-iodo-2'-deoxyuridine (IdUrd).
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Humans; Idoxuridine; Male; Middle Aged; Neoplasms; Nucleic Acid Synthesis Inhibitors; Quinazolines; Thiophenes | 2001 |
Second-line treatment with oxaliplatin + raltitrexed in patients with advanced colorectal cancer failing fluoropyrimidine/leucovorin-based chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neutropenia; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Salvage Therapy; Thiophenes; Treatment Outcome | 2001 |
Preoperative chemoradiation with raltitrexed ('Tomudex') for T2/N+ and T3/N+ rectal cancers: a phase I study.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Female; Humans; Leukopenia; Male; Middle Aged; Quinazolines; Radiotherapy, Adjuvant; Rectal Neoplasms; Thiophenes | 2001 |
Phase I clinical and pharmacogenetic trial of irinotecan and raltitrexed administered every 21 days to patients with cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Diarrhea; Dose-Response Relationship, Drug; Fatigue; Female; Genotype; Homocysteine; Humans; Irinotecan; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasms; Neutropenia; Oxidoreductases Acting on CH-NH Group Donors; Quinazolines; Thiophenes | 2001 |
Randomized multicenter phase II trial of oxaliplatin plus irinotecan versus raltitrexed as first-line treatment in advanced colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Cross-Over Studies; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Irinotecan; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Quinazolines; Survival Rate; Thiophenes | 2002 |
Patterns of elevation of plasma 2'-deoxyuridine, a surrogate marker of thymidylate synthase (TS) inhibition, after administration of two different schedules of 5-fluorouracil and the specific TS inhibitors raltitrexed (Tomudex) and ZD9331.
Topics: Antimetabolites, Antineoplastic; Biomarkers, Tumor; Colorectal Neoplasms; Deoxyuridine; Enzyme Inhibitors; Fluorouracil; Humans; Infusions, Intravenous; Quinazolines; Thiophenes; Thymidylate Synthase | 2002 |
Raltitrexed (Tomudex) administration in patients with relapsed metastatic colorectal cancer after weekly irinotecan/5-Fluorouracil/Leucovorin chemotherapy.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Peritoneal Neoplasms; Quinazolines; Salvage Therapy; Secondary Prevention; Thiophenes; Treatment Outcome | 2002 |
Phase I dose-escalating study of raltitrexed ('Tomudex') and cisplatin in metastatic non-small cell lung cancer.
Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neutropenia; Quinazolines; Thiophenes; Thrombocytopenia | 2002 |
Raltitrexed (tomudex) administration in patients failing multiple prior chemotherapy regimens in advanced colorectal cancer: a pilot study.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Pilot Projects; Quinazolines; Thiophenes; Thymidylate Synthase | 2002 |
Raltitrexed in the treatment of elderly patients with advanced colorectal cancer: an active and low toxicity regimen.
Topics: Age Factors; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Progression; Female; Humans; Male; Neoplasm Metastasis; Neoplasm Recurrence, Local; Palliative Care; Quinazolines; Sex Factors; Survival Analysis; Thiophenes; Treatment Outcome | 2002 |
Raltitrexed plus oxaliplatin (TOMOX) as first-line chemotherapy for metastatic colorectal cancer. A phase II study of the Italian Group for the Study of Gastrointestinal Tract Carcinomas (GISCAD).
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Italy; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Quinazolines; Risk Assessment; Survival Analysis; Thiophenes; Treatment Outcome | 2002 |
Oxaliplatin plus raltitrexed and leucovorin-modulated 5-fluorouracil i.v. bolus: a salvage regimen for colorectal cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Salvage Therapy; Thiophenes; Treatment Outcome | 2002 |
Ralitrexed (Tomudex) or Nordic-FLv regimen in metastatic colorectal cancer: a randomized phase II study focusing on quality of life, patients' preferences and health economics.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Health Care Costs; Humans; Length of Stay; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Norway; Quality of Life; Quinazolines; Surveys and Questionnaires; Survival Analysis; Thiophenes; Treatment Outcome | 2002 |
Multicenter non-randomized phase II study of raltitrexed (Tomudex) and oxaliplatin in non-pretreated metastatic colorectal cancer patients.
Topics: Adenocarcinoma; Adult; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Pyridines; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome | 2002 |
Multicenter phase I study of irinotecan plus raltitrexed in patients with 5-fluorouracil-refractory advanced colorectal cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Neoplasm Staging; Quinazolines; Thiophenes; Treatment Outcome | 2002 |
Raltitrexed plus oxaliplatin as first-line chemotherapy in metastatic colorectal carcinoma: a multicentric phase II trial.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colorectal Neoplasms; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2002 |
Irinotecan and raltitrexed: an active combination in advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Irinotecan; Male; Middle Aged; Neoplasm Staging; Palliative Care; Probability; Prognosis; Quinazolines; Severity of Illness Index; Survival Analysis; Thiophenes; Treatment Outcome | 2002 |
Phase I and pharmacokinetic study of irinotecan in combination with raltitrexed.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Diarrhea; Drug Administration Schedule; Fatigue; Female; Humans; Irinotecan; Male; Middle Aged; Neoplasms; Neutropenia; Quinazolines; Thiophenes | 2002 |
Cisplatin, raltitrexed, levofolinic acid and 5-fluorouracil in locally advanced or metastatic squamous cell carcinoma of the head and neck: a phase II randomized study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Dose-Response Relationship, Drug; Female; Fluorouracil; Head and Neck Neoplasms; Hematologic Diseases; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Neutropenia; Quinazolines; Thiophenes; Treatment Outcome | 2002 |
[Raltitrexed and oxaliplatin in colorectal cancer: in vitro and in vivo study of a synergistic cytostatic combination].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Colorectal Neoplasms; Disease-Free Survival; Drug Synergism; Drug Therapy, Combination; Follow-Up Studies; Humans; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Time Factors; Tumor Cells, Cultured | 2002 |
The raltitrexed-vinorelbine combination: a phase I pharmacokinetic and pharmacodynamic trial in advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Maximum Tolerated Dose; Middle Aged; Quinazolines; Safety; Salvage Therapy; Thiophenes; Treatment Outcome; Vinblastine; Vinorelbine | 2002 |
Combination of raltitrexed and oxaliplatin is an active regimen in malignant mesothelioma: results of a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Disease Progression; Dose-Response Relationship, Drug; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Male; Mesothelioma; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Peritoneal Neoplasms; Pleural Neoplasms; Prognosis; Quinazolines; Survival Rate; Thiophenes; Treatment Outcome | 2003 |
The activity of raltitrexed (Tomudex) in malignant pleural mesothelioma: an EORTC phase II study (08992).
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Female; Humans; Male; Mesothelioma; Middle Aged; Pleural Neoplasms; Quinazolines; Retrospective Studies; Survival Analysis; Thiophenes; Treatment Outcome | 2003 |
Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed.
Topics: Antimetabolites, Antineoplastic; Base Sequence; Colorectal Neoplasms; DNA Primers; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Predictive Value of Tests; Protein Biosynthesis; Quinazolines; Radiography; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; Thymidylate Synthase; Transcription, Genetic; Treatment Outcome | 2003 |
Comparison of intermittent and continuous palliative chemotherapy for advanced colorectal cancer: a multicentre randomised trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Humans; Infusion Pumps; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasm Staging; Palliative Care; Quinazolines; Survival Analysis; Thiophenes | 2003 |
Raltitrexed plus radiotherapy for the treatment of unresectable/recurrent rectal cancer: a phase I study.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Combined Modality Therapy; Diarrhea; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Quinazolines; Rectal Neoplasms; Thiophenes | 2003 |
Activity of raltitrexed and gemcitabine in advanced pancreatic cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Diarrhea; Disease Progression; Drug Administration Schedule; Female; Gemcitabine; Humans; Infusions, Intravenous; Male; Middle Aged; Nausea; Pancreatic Neoplasms; Quinazolines; Thiophenes; Treatment Outcome; Vomiting | 2003 |
Irinotecan plus raltitrexed vs raltitrexed alone in patients with gemcitabine-pretreated advanced pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Humans; Irinotecan; Male; Middle Aged; Pancreatic Neoplasms; Quinazolines; Survival Analysis; Thiophenes; Time Factors; Treatment Outcome | 2003 |
Second-line treatment of advanced gastric cancer with oxaliplatin plus raltitrexed.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Disease Progression; Disease-Free Survival; Female; Humans; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Quinazolines; Retreatment; Salvage Therapy; Stomach Neoplasms; Survival Rate; Thiophenes | 2003 |
Multicenter phase II trial evaluating a three-weekly schedule of irinotecan plus raltitrexed in patients with 5-fluorouracil-refractory advanced colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome | 2003 |
Lessons learned from raltitrexed--quality assurance, patient education and intensive supportive drugs to optimise tolerability.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Fluorouracil; Health Education; Humans; Male; Middle Aged; Quality Assurance, Health Care; Quinazolines; Thiophenes | 2003 |
Raltitrexed-induced hepatotoxicity: multivariate analysis of predictive factors.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Folic Acid Antagonists; Humans; Logistic Models; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Predictive Value of Tests; Quinazolines; Thiophenes; Transaminases | 2003 |
Oxaliplatin- or irinotecan-based chemotherapy for metastatic colorectal cancer in the elderly.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome | 2003 |
A phase I and pharmacokinetic study of irinotecan given as a 7-day continuous infusion in metastatic colorectal cancer patients pretreated with 5-fluorouracil or raltitrexed.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Diarrhea; Female; Fluorouracil; Glucuronides; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Nausea; Neoplasm Metastasis; Patient Selection; Quinazolines; Thiophenes; Vomiting | 2004 |
Phase I trial of sequential raltitrexed followed by bolus 5-fluorouracil in patients with advanced colorectal cancer.
Topics: Adult; Aged; Colorectal Neoplasms; Confidence Intervals; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Odds Ratio; Quinazolines; Survival Analysis; Thiophenes | 2004 |
Population pharmacokinetics of raltitrexed in patients with advanced solid tumours.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Female; Humans; Male; Middle Aged; Neoplasms; Quinazolines; Thiophenes | 2004 |
Raltitrexed plus weekly oxaliplatin as first-line chemotherapy in metastatic colorectal cancer: a multicenter non-randomized phase ii study.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Survival Rate; Thiophenes; Treatment Outcome | 2004 |
Irinotecan plus raltitrexed as first-line treatment in advanced colorectal cancer: a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Female; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome | 2004 |
Chemoradiation with raltitrexed (Tomudex) in preoperative treatment of stage II-III resectable rectal cancer: a phase II study.
Topics: Aged; Antimetabolites, Antineoplastic; Female; Fluorouracil; Folic Acid; Follow-Up Studies; Hematinics; Humans; Male; Middle Aged; Neoplasm Staging; Quinazolines; Radiotherapy, Conformal; Rectal Neoplasms; Thiophenes | 2004 |
Chemoradiation with raltitrexed and oxaliplatin in preoperative treatment of stage II-III resectable rectal cancer: Phase I and II studies.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Radiotherapy Dosage; Rectal Neoplasms; Thiophenes | 2004 |
Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Peritoneal Neoplasms; Prospective Studies; Quinazolines; Salvage Therapy; Survival Rate; Thiophenes; Thymidylate Synthase; Treatment Outcome | 2004 |
Phase I study of Tomudex and Doxorubicin in patients with locally advanced, inoperable or metastatic cancer (IND.98).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Doxorubicin; Female; Head and Neck Neoplasms; Humans; Liver Neoplasms; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Quinazolines; Salvage Therapy; Stomach Neoplasms; Thiophenes | 2005 |
Epirubicin, cisplatin, and raltitrexed in patients with advanced gastric and hepatobiliary carcinoma: a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Cisplatin; Epirubicin; Female; Humans; Liver Neoplasms; Male; Middle Aged; Quinazolines; Stomach Neoplasms; Survival Analysis; Thiophenes | 2004 |
A phase II study of raltitrexed and gemcitabine in patients with advanced pancreatic carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Diarrhea; Drug Administration Schedule; Female; Gemcitabine; Humans; Male; Middle Aged; Neutropenia; Pancreatic Neoplasms; Quinazolines; Survival Rate; Thiophenes | 2005 |
Raltitrexed plus gemcitabine (TOMGEM) in advanced pancreatic cancer. Results of a Belgian multicentre phase II study.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Belgium; Deoxycytidine; Disease-Free Survival; Drug Administration Schedule; Female; Gemcitabine; Humans; Male; Middle Aged; Pancreatic Neoplasms; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome | 2004 |
Phase I study of concomitant chemoradiation with raltitrexed in locally advanced head and neck cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Quinazolines; Radiotherapy; Thiophenes | 2005 |
Phase I trial and pharmacokinetic study of raltitrexed in children with recurrent or refractory leukemia: a pediatric oncology group study.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Humans; Infant; Infusions, Intravenous; Leukemia; Male; Maximum Tolerated Dose; Quinazolines; Thiophenes; Treatment Outcome | 2005 |
First-line treatment with irinotecan and raltitrexed in metastatic colorectal cancer. Mature results of a multicenter phase II study.
Topics: Adult; Aged; Anemia; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Camptothecin; Colorectal Neoplasms; Diarrhea; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Incidence; Irinotecan; Male; Middle Aged; Neutropenia; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome; Vomiting | 2005 |
Raltitrexed-Oxaliplatin combination chemotherapy is inactive as second-line treatment for malignant pleural mesothelioma patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Infusions, Intravenous; Male; Mesothelioma; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Pleural Neoplasms; Quinazolines; Thiophenes; Treatment Outcome | 2005 |
A phase II trial of raltitrexed (Tomudex) in advanced pancreatic and biliary carcinoma.
Topics: Antimetabolites, Antineoplastic; Biliary Tract Neoplasms; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Pancreatic Neoplasms; Quality of Life; Quinazolines; Survival Rate; Thiophenes; Thymidylate Synthase; Treatment Outcome | 2005 |
Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Humans; Infusions, Intravenous; Male; Mesothelioma; Middle Aged; Neutropenia; Pleural Neoplasms; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome; Vomiting | 2005 |
Phase II randomised trial of raltitrexed-oxaliplatin vs raltitrexed-irinotecan as first-line treatment in advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome | 2005 |
A National Cancer Institute of Canada Clinical Trials Group Study--IND.135: Phase I/II study of irinotecan (camptosar), oxaliplatin and raltitrexed (tomudex) (COT) in patients with advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Canada; Cohort Studies; Colorectal Neoplasms; Female; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Treatment Outcome | 2006 |
Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: A multicentric phase II study.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents; Combined Modality Therapy; Dose Fractionation, Radiation; Female; Fluorouracil; Humans; Italy; Male; Middle Aged; Neoplasm Recurrence, Local; Pain Management; Quinazolines; Radiotherapy; Rectal Neoplasms; Thiophenes; Treatment Failure | 2006 |
Short-term treatment-related symptoms and quality of life: results from an international randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an EORTC Lung-Cancer Group and National Cancer In
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Humans; Infusions, Intravenous; Male; Mesothelioma; Middle Aged; Pleural Neoplasms; Quality of Life; Quinazolines; Thiophenes; Treatment Outcome | 2006 |
Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbon-Nitrogen Ligases; Carcinoma; Colorectal Neoplasms; Diarrhea; Fatigue; Female; Genotype; Glucuronosyltransferase; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Neutropenia; Polymorphism, Genetic; Predictive Value of Tests; Promoter Regions, Genetic; Quinazolines; Thiophenes; Thymidylate Synthase; Vomiting | 2006 |
Raltitrexed-eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Progression; Drug Resistance, Neoplasm; Female; Gemcitabine; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Quality of Life; Quinazolines; Salvage Therapy; Survival Analysis; Thiophenes | 2006 |
Raltitrexed plus oxaliplatin in the second-line treatment of metastatic colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Salvage Therapy; Thiophenes; Treatment Outcome | 2006 |
Biweekly oxaliplatin, raltitrexed, 5-fluorouracil and folinic acid combination chemotherapy during preoperative radiation therapy for locally advanced rectal cancer: a phase I-II study.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Digestive System Surgical Procedures; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Organoplatinum Compounds; Oxaliplatin; Preoperative Care; Quinazolines; Thiophenes | 2006 |
Raltitrexed plus levofolinic acid and bolus/continuous infusion 5-fluorouracil on a biweekly schedule for elderly patients with advanced colorectal carcinomas.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Neoplasm Metastasis; Neoplasm Recurrence, Local; Quinazolines; Thiophenes | 2006 |
Randomised trial comparing three different schedules of infusional 5FU and raltitrexed alone as first-line therapy in metastatic colorectal cancer. Final results of the Fédération Francophone de Cancérologie Digestive (FFCD) 9601 trial.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; France; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Staging; Quality of Life; Quinazolines; Thiophenes; Treatment Outcome | 2006 |
The combination of raltitrexed (Tomudex) and mitomycin-C in the treatment of advanced colorectal cancer--a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Mitomycin; Quality of Life; Quinazolines; Survival Rate; Thiophenes; Treatment Outcome | 2006 |
Cost-effectiveness analysis of first-line chemotherapies in metastatic colorectal cancer. Results of the Fédération Francophone de Cancérologie Digestive (FFCD) 9601 randomized trial.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Cost of Illness; Cost-Benefit Analysis; Disease-Free Survival; Female; Fluorouracil; France; Health Care Costs; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Quinazolines; Survival Rate; Thiophenes; Treatment Outcome | 2006 |
Randomized, multicenter, phase IIb study of preoperative chemoradiotherapy in T3 mid-distal rectal cancer: raltitrexed + oxaliplatin + radiotherapy versus cisplatin + 5-fluorouracil + radiotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Prospective Studies; Quinazolines; Radiotherapy Dosage; Rectal Neoplasms; Thiophenes | 2008 |
Symptoms and patient-reported well-being: do they predict survival in malignant pleural mesothelioma? A prognostic factor analysis of EORTC-NCIC 08983: randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural
Topics: Antineoplastic Agents; Cisplatin; Female; Humans; Male; Mesothelioma; Middle Aged; Pleural Neoplasms; Prognosis; Prospective Studies; Quality of Life; Quinazolines; Self-Assessment; Thiophenes | 2007 |
Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: Results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1).
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome; Young Adult | 2008 |
A randomized phase II study of raltitrexed and gefitinib versus raltitrexed alone as second line chemotherapy in patients with colorectal cancer. (1839IL/0143).
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Colorectal Neoplasms; Demography; Female; Gefitinib; Humans; Male; Middle Aged; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome; Young Adult | 2011 |
Neoadjuvant accelerated concomitant boost radiotherapy and multidrug chemotherapy in locally advanced rectal cancer: a dose-escalation study.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Peritoneal Neoplasms; Quinazolines; Rectal Neoplasms; Thiophenes; Treatment Outcome | 2012 |
Concomitant boost radiotherapy and multidrug chemotherapy in the neoadjuvant treatment of locally advanced rectal cancer: results of a phase II study.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Chemotherapy, Adjuvant; Female; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Radiotherapy; Radiotherapy, Adjuvant; Rectal Neoplasms; Thiophenes | 2011 |
A randomized phase II study to compare oxaliplatin plus 5-fluorouracil and leucovorin (FOLFOX4) versus oxaliplatin plus raltitrexed (TOMOX) as first-line chemotherapy for advanced colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2012 |
[Effectiveness of combined systemic and regional chemotherapy in treating patients with metastatic colorectal cancer after extrahepatic progression of the disease].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Cancer, Regional Perfusion; Colorectal Neoplasms; Disease Progression; Doxorubicin; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Leucovorin; Liver Neoplasms; Male; Middle Aged; Mitomycin; Organoplatinum Compounds; Quinazolines; Thiophenes; Treatment Outcome | 2013 |
Preliminary investigation of intraperitoneal raltitrexed in patients with gastric cancer.
Topics: Adult; Antimetabolites, Antineoplastic; Double-Blind Method; Female; Humans; Injections, Intraperitoneal; Male; Middle Aged; Neoplasm Seeding; Prospective Studies; Quinazolines; Stomach Neoplasms; Thiophenes | 2014 |
Critical role of bevacizumab scheduling in combination with pre-surgical chemo-radiotherapy in MRI-defined high-risk locally advanced rectal cancer: Results of the BRANCH trial.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Chemoradiotherapy, Adjuvant; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Early Termination of Clinical Trials; Female; Fluorouracil; Humans; Italy; Kaplan-Meier Estimate; Leucovorin; Magnetic Resonance Imaging; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Predictive Value of Tests; Quinazolines; Rectal Neoplasms; Risk Factors; Thiophenes; Time Factors; Treatment Outcome | 2015 |
Raltitrexed plus oxaliplatin-based transarterial chemoembolization in patients with unresectable hepatocellular carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Doxorubicin; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Young Adult | 2016 |
Concurrent Chemoradiation with Concomitant Boost in Locally Advanced Rectal Cancer: A Phase II Study.
Topics: Adult; Aged; Chemoradiotherapy; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Radiotherapy Dosage; Rectal Neoplasms; Thiophenes | 2016 |
Can carcinoembryonic antigen replace computed tomography in response evaluation of metastatic colorectal cancer?
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Biomarkers, Tumor; Carcinoembryonic Antigen; Colorectal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Quinazolines; ROC Curve; Sensitivity and Specificity; Thiophenes; Tomography, X-Ray Computed | 2018 |
S-1 plus Raltitrexed for Refractory Metastatic Colorectal Cancer: A Phase II Trial.
Topics: Adult; Aged; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Oxonic Acid; Quinazolines; Tegafur; Thiophenes | 2019 |
Concurrent chemoradiotherapy with raltitrexed and nedaplatin regimen for esophageal squamous cell carcinoma.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Dose-Response Relationship, Radiation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Humans; Longitudinal Studies; Male; Middle Aged; Organoplatinum Compounds; Quinazolines; Retrospective Studies; Thiophenes; Treatment Outcome | 2020 |
Hepatic arterial infusion of oxaliplatin plus raltitrexed in patients with intermediate and advanced stage hepatocellular carcinoma: A phase II, single-arm, prospective study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Follow-Up Studies; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Oxaliplatin; Prognosis; Prospective Studies; Quinazolines; Survival Rate; Thiophenes | 2020 |
Raltitrexed versus 5-fluorouracil with cisplatin and concurrent radiotherapy for locally advanced nasopharyngeal carcinoma: An open labeled, randomized, controlled, and multicenter clinical trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chemoradiotherapy; Chi-Square Distribution; Cisplatin; Female; Fluorouracil; Humans; Male; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Progression-Free Survival; Quinazolines; Stomatitis; Thiophenes; Young Adult | 2020 |
A prospective phase II study of raltitrexed combined with S-1 as salvage treatment for patients with refractory metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Prospective Studies; Quinazolines; Salvage Therapy; Thiophenes; Treatment Outcome | 2021 |
Bevacizumab Combined with S-1 and Raltitrexed for Patients with Metastatic Colorectal Cancer Refractory to Standard Therapies: A Phase II Study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Quinazolines; Thiophenes | 2021 |
273 other study(ies) available for quinazolines and raltitrexed
| Article | Year |
|---|---|
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
Topics: Acyltransferases; Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Male; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates.
Topics: Antineoplastic Agents; Folic Acid Antagonists; Polyglutamic Acid; Quinazolines; Thiophenes; Thymidylate Synthase | 1992 |
Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor.
Topics: Cell Division; Cell Line; DNA; DNA Damage; DNA, Single-Stranded; Fluorouracil; Formyltetrahydrofolates; Methotrexate; Quinazolines; Rhodamines; Thiophenes; Thymidine; Thymidylate Synthase; Time Factors | 1992 |
Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.
Topics: Animals; Binding Sites; Cell Division; Kinetics; Leukemia L1210; Mice; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
ICI D1694, an inhibitor of thymidylate synthase for clinical study.
Topics: Animals; Breast Neoplasms; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Female; Folic Acid Antagonists; Humans; Leukemia L1210; Mice; Neoplasms, Experimental; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1991 |
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
Topics: Animals; Carrier Proteins; Cell Division; Drug Screening Assays, Antitumor; Folate Receptors, GPI-Anchored; Folic Acid; Glutamates; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase | 1991 |
The pharmacokinetics of the quinazoline antifolate ICI D 1694 in mice and rats.
Topics: Animals; Antineoplastic Agents; Blood Proteins; Chromatography, High Pressure Liquid; Female; Folic Acid; Folic Acid Antagonists; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Protein Binding; Quinazolines; Rats; Rats, Inbred Strains; Thiophenes; Time Factors; Tissue Distribution | 1991 |
The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice.
Topics: Animals; Carbon Radioisotopes; Cisplatin; Creatinine; Female; Folic Acid; Glomerular Filtration Rate; Inulin; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinazolines; Thiophenes; Thymidylate Synthase; Urea | 1991 |
Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.
Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1991 |
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1995 |
Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694.
Topics: Antineoplastic Agents; Base Sequence; Blotting, Southern; Blotting, Western; DNA; DNA, Neoplasm; Drug Resistance; Female; Folic Acid; Humans; Lymphocytes; Molecular Sequence Data; Neoplasm Proteins; Ovarian Neoplasms; Polymerase Chain Reaction; Proteins; Quinazolines; RNA; RNA, Neoplasm; Thiophenes; Thymidylate Synthase; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Fluorouracil: active in ZD1694 (tomudex)-resistant cell lines with markedly elevated thymidylate synthase levels.
Topics: Drug Resistance; Fluorouracil; Humans; Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Contrasting patterns of DNA fragmentation induced by thymidylate synthase inhibitors, ZD1694 and AG-331.
Topics: Antimetabolites, Antineoplastic; Aphidicolin; Cell Division; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Floxuridine; Fluorouracil; Genome; Humans; Indoles; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Topoisomerase I inhibitors and other new cytotoxic drugs.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aziridines; Camptothecin; Deoxycytidine; Doxorubicin; Gemcitabine; Humans; Indolequinones; Indoles; Irinotecan; Lactones; Macrolides; Organoplatinum Compounds; Quinazolines; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors | 1995 |
Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
Topics: Aminopterin; Animals; Carrier Proteins; Cell Division; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Haplorhini; Humans; Kidney; Leucovorin; Methotrexate; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Quinazolines; Receptors, Cell Surface; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured | 1995 |
Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line.
Topics: Cell Division; Cell-Free System; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Pemetrexed; Peptide Synthases; Pteroylpolyglutamic Acids; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured | 1995 |
Relationships between resistance to cisplatin and antifolates in sensitive and resistant tumour cell lines.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Resistance; Female; Folic Acid; Folic Acid Antagonists; Humans; Male; Ovarian Neoplasms; Quinazolines; Testicular Neoplasms; Thiophenes; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1995 |
Cross-resistance to thymidylate synthase inhibitors in P-glycoprotein and non-P-glycoprotein cell lines.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Cycle; Cell Line; Clone Cells; Doxorubicin; Drug Resistance, Multiple; Fluorodeoxyuridylate; Fluorouracil; Humans; Lung Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Humans; Mice; Polyglutamic Acid; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase.
Topics: Animals; Cell Survival; Deoxyadenine Nucleotides; Drug Interactions; Floxuridine; Folic Acid; Hypoxanthine; Hypoxanthines; Leukemia L1210; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.
Topics: Carrier Proteins; Humans; Indoles; Membrane Proteins; Nucleoside Transport Proteins; Quinazolines; Thiophenes; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1995 |
Modulation of target enzyme associated with the action of antifolates.
Topics: Antimetabolites, Antineoplastic; Carcinoma; Dose-Response Relationship, Drug; Drug Interactions; Evaluation Studies as Topic; Humans; Intestinal Neoplasms; Leucovorin; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells.
Topics: Cell Survival; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; In Vitro Techniques; Indoles; Isoindoles; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
ICI D1694 and idoxuridine: a synergistic antitumor combination.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; DNA Damage; Drug Synergism; Humans; Idoxuridine; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays.
Topics: Cell Division; Cell Survival; DNA; DNA Damage; DNA Repair; Humans; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
The history of the development and clinical use of CB 3717 and ICI D1694.
Topics: Animals; Antimetabolites, Antineoplastic; Clinical Trials, Phase I as Topic; Folic Acid; History, 20th Century; Molecular Structure; Quinazolines; Thiophenes; Thymidylate Synthase; United Kingdom | 1993 |
Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.
Topics: Animals; Antimalarials; Cell Division; Erythrocytes; Folic Acid Antagonists; HeLa Cells; Humans; In Vitro Techniques; Mice; Plasmodium falciparum; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
Topics: Acyltransferases; Antineoplastic Agents; Cell Division; Cell Survival; Colonic Neoplasms; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Hypoxanthines; Methotrexate; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Division; Drug Resistance; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured | 1993 |
Combination studies with 3'-azido-3'-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects.
Topics: Colony-Forming Units Assay; DNA Damage; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Hematopoietic Stem Cells; Humans; Quinazolines; Thiophenes; Thymidylate Synthase; Tritium; Tumor Cells, Cultured; Zidovudine | 1993 |
Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents.
Topics: Animals; Antineoplastic Agents; Dipeptides; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 1993 |
Use of murine L5178Y lymphoma thymidine kinase mutants for in vitro and in vivo antitumour efficacy evaluation of novel thymidylate synthase inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L5178; Mice; Mice, Inbred DBA; Mutation; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.
Topics: Animals; Antineoplastic Agents; Cell Division; Deoxyuracil Nucleotides; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Thymine Nucleotides | 1993 |
The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme.
Topics: Cell Cycle; Cell Division; Cells, Cultured; Cycloheximide; Enzyme Stability; Humans; Protein Biosynthesis; Quinazolines; RNA, Messenger; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine.
Topics: Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Effect of hammerhead ribozyme against human thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitors.
Topics: B-Lymphocytes; Base Sequence; Drug Resistance; Drug Synergism; Enzyme Induction; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Molecular Sequence Data; Nucleic Acid Conformation; Quinazolines; Repetitive Sequences, Nucleic Acid; RNA, Catalytic; RNA, Messenger; Thiophenes; Thymidylate Synthase; Transfection; Trimetrexate | 1995 |
Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug.
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Humans; Intracellular Fluid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Tritium; Tumor Cells, Cultured | 1996 |
The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells.
Topics: Antimetabolites, Antineoplastic; Drug Resistance; gamma-Glutamyl Hydrolase; Gene Expression Regulation, Enzymologic; Humans; Leukemia; Methotrexate; Peptide Synthases; Pteroylpolyglutamic Acids; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Binding Sites; Breast Neoplasms; Carrier Proteins; Cell Membrane; DNA, Complementary; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Polymerase Chain Reaction; Quinazolines; Receptors, Cell Surface; RNA, Messenger; Spectrometry, Fluorescence; Structure-Activity Relationship; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured | 1996 |
Raltitrexed, a new drug for advanced colorectal cancer.
Topics: Colorectal Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Humans; Infusions, Intravenous; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
Biological activity and intracellular metabolism of ZD1694 in human leukemia cell lines with different resistance mechanisms to antifolate drugs.
Topics: Antimetabolites, Antineoplastic; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Polyglutamic Acid; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Tumor Cells, Cultured | 1996 |
Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
Topics: Animals; Deoxyuracil Nucleotides; Dipeptides; Dose-Response Relationship, Drug; Folic Acid Antagonists; Leukemia, Experimental; Mice; Mice, Inbred Strains; Quinazolines; Radioimmunoassay; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1996 |
Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines.
Topics: Blotting, Northern; Blotting, Western; Breast Neoplasms; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; Humans; Quinazolines; Thiophenes; Time Factors; Tumor Cells, Cultured | 1996 |
Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694.
Topics: Animals; Antimalarials; Enzyme Inhibitors; Fluorodeoxyuridylate; Kinetics; Orotic Acid; Plasmodium falciparum; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
Clinical trials referral resource. Clinical trials with tomudex.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Leukemia; Male; Prostatic Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Cycle; Cell Division; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; DNA Replication; DNA, Neoplasm; G1 Phase; G2 Phase; Humans; Neoplasm Proteins; Quinazolines; S Phase; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1996 |
Modulation of [5-125I]iododeoxyuridine incorporation into tumour and normal tissue DNA by methotrexate and thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Female; Fluorouracil; Idoxuridine; Intestine, Small; Iodine Radioisotopes; Liver; Mammary Neoplasms, Experimental; Methotrexate; Mice; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Quinazolines; Thiophenes; Thymidylate Synthase; Uracil | 1996 |
Trichinella spiralis thymidylate synthase: developmental pattern, isolation, molecular properties, and inhibition by substrate and cofactor analogues.
Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Fluorodeoxyuridylate; Folic Acid; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Larva; Liver; Liver Regeneration; Muscles; Quinazolines; Rats; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Trichinella spiralis | 1996 |
Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity.
Topics: Antimetabolites, Antineoplastic; Binding Sites; Computer Simulation; Crystallography, X-Ray; Escherichia coli; Folic Acid; Folic Acid Antagonists; Humans; Models, Molecular; Molecular Conformation; Protein Conformation; Protein Structure, Secondary; Quinazolines; Species Specificity; Thiophenes; Thymidylate Synthase | 1996 |
Cost of treating advanced colorectal cancer: a retrospective comparison of treatment regimens.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colorectal Neoplasms; England; Female; Fluorouracil; Hospital Costs; Humans; Male; Middle Aged; Quinazolines; Retrospective Studies; Thiophenes | 1996 |
Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT).
Topics: Antineoplastic Agents; Biotransformation; Carboxypeptidases; Carboxypeptidases A; Drug Delivery Systems; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Humans; Prodrugs; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation.
Topics: Animals; Apoptosis; Colon; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Histocytochemistry; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Male; Mice; Mice, Inbred Strains; Quinazolines; RNA; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Suppressor Protein p53; Uridine | 1997 |
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Acyltransferases; Aminohydrolases; Antimetabolites, Antineoplastic; Folic Acid Antagonists; Formate-Tetrahydrofolate Ligase; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Molecular Structure; Multienzyme Complexes; Oxidoreductases; Pemetrexed; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Polyglutamic Acid; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
p53 and WAF1 are induced and Rb protein is hypophosphorylated during cell growth inhibition by the thymidylate synthase inhibitor ZD1694 (Tomudex).
Topics: Adenocarcinoma; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; DNA, Neoplasm; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Gene Expression; Humans; Ileal Neoplasms; Phosphorylation; Quinazolines; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; RNA, Messenger; Thiophenes; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Interference by antifolate drugs in a folate competitive protein-binding assay.
Topics: Folic Acid; Folic Acid Antagonists; Humans; Protein Binding; Quinazolines; Radioimmunoassay; Thiophenes | 1997 |
[Selective oral aromatase suppression and thymidilate synthase inhibition].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Ligases; Mastectomy; Palliative Care; Postoperative Care; Quinazolines; Thiophenes | 1997 |
Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells.
Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA-Binding Proteins; Doxorubicin; E2F Transcription Factors; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Methotrexate; Osteosarcoma; Phosphorylation; Quinazolines; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; Tetracycline; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured | 1997 |
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid Antagonists; HL-60 Cells; Humans; Indoles; Isoindoles; Kinetics; Leukemia, Myeloid; Methotrexate; Neoplasm Proteins; Organ Specificity; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Division; Drug Resistance, Multiple; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Humans; Indoles; Isoindoles; Methotrexate; Peptide Synthases; Polymerase Chain Reaction; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Confocal microscopy visualization of antifolate uptake by the reduced folate carrier in human leukaemic cells.
Topics: Biological Transport; Carrier Proteins; Folic Acid Antagonists; Humans; Leukemia; Membrane Proteins; Membrane Transport Proteins; Microscopy, Confocal; Quinazolines; Reduced Folate Carrier Protein; Thiophenes; Tumor Cells, Cultured | 1997 |
Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Colonic Neoplasms; Deoxyuracil Nucleotides; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Kinetics; Pyrophosphatases; Quinazolines; Templates, Genetic; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1997 |
Recent advances in the study of rTS proteins. rTS expression during growth and in response to thymidylate synthase inhibitors in human tumor cells.
Topics: Blotting, Western; Cell Division; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Floxuridine; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Humans; Hydro-Lyases; Indoles; Isoindoles; Protein Biosynthesis; Proteins; Quinazolines; Racemases and Epimerases; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models.
Topics: Animals; Antimetabolites, Antineoplastic; Dogs; Female; Male; Mice; Mice, Inbred DBA; Polyglutamic Acid; Quinazolines; Radioimmunoassay; Thiophenes; Thymidylate Synthase; Tissue Distribution | 1998 |
Variable expression of RFC1 in human leukemia cell lines resistant to antifolates.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Tumor Cells, Cultured | 1998 |
Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Fluorouracil; Humans; Nucleotides; Phosphoribosyl Pyrophosphate; Quinazolines; RNA, Neoplasm; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Electrocardiography; Female; Fluorouracil; Heart; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Quinazolines; Sigmoid Neoplasms; Thiophenes; Thymidylate Synthase | 1998 |
Increased cell killing and mutagenecity by DNA alkylating agents in cells with decreased TTP pools.
Topics: Alkylating Agents; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethyl Methanesulfonate; HL-60 Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Methylnitronitrosoguanidine; Mutagens; Quinazolines; Thiophenes; Thymidylate Synthase; Thymine Nucleotides | 1998 |
Schedule-dependent synergism between raltitrexed and irinotecan in human colon cancer cells in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Irinotecan; Quinazolines; Thiophenes; Tumor Cells, Cultured | 1998 |
Combined therapeutic efficacy of the thymidylate synthase inhibitor ZD1694 (Tomudex) and the immunotoxin B43(anti-CD19)-PAP in a SCID mouse model of human B-lineage acute lymphoblastic leukemia.
Topics: Animals; Antigens, CD19; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; B-Lymphocytes; Cell Lineage; Combined Modality Therapy; Disease Models, Animal; Enzyme Inhibitors; Humans; Immunotoxins; Mice; Mice, SCID; N-Glycosyl Hydrolases; Plant Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Ribosome Inactivating Proteins, Type 1; Survival Analysis; Thiophenes; Thymidylate Synthase | 1998 |
Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Culture Media, Conditioned; Dose-Response Relationship, Drug; Female; Humans; Quinazolines; Thiophenes; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Time Factors; Transfection; Tumor Cells, Cultured | 1998 |
Colon cancer: new drug options improve on 5-FU.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Survival Analysis; Tegafur; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome | 1998 |
Interaction of tomudex with radiation in vitro and in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Lewis Lung; Carcinoma, Squamous Cell; Cell Survival; Combined Modality Therapy; Drug Interactions; Enzyme Inhibitors; Fluorouracil; Head and Neck Neoplasms; HT29 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms; Quinazolines; Radiation Tolerance; Thiophenes; Thymidylate Synthase; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Nucleotides; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Reproducibility of Results; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.
Topics: Animals; Antimetabolites, Antineoplastic; Binding Sites; Bone Marrow Cells; Drug Resistance; Folic Acid; Folic Acid Antagonists; Granulocytes; Humans; Indoles; Isoindoles; Isoleucine; Kinetics; Macrophages; Mice; Models, Molecular; Mutagenesis, Site-Directed; Quinazolines; Recombinant Proteins; Stem Cells; Thiophenes; Thymidylate Synthase | 1998 |
Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Division; Cell Survival; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Kinetics; Methotrexate; Purines; Quinazolines; Sarcoma; Tetrahydrofolates; Thiophenes; Thymidine Monophosphate; Tumor Cells, Cultured | 1995 |
Comparative genomic hybridization analysis of chromosomal alterations induced by the development of resistance to thymidylate synthase inhibitors.
Topics: Antimetabolites, Antineoplastic; Chromosomes, Human, Pair 18; Chromosomes, Human, Pair 20; Drug Resistance, Neoplasm; Fluorouracil; Humans; Nucleic Acid Hybridization; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
Second line treatment options in advanced colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Humans; Mitomycin; Quinazolines; Thiophenes; Thymidylate Synthase | 1998 |
Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.
Topics: Animals; Antimetabolites, Antineoplastic; Bacterial Proteins; Carcinoma, Hepatocellular; Computer Simulation; Crystallography, X-Ray; Deoxyuracil Nucleotides; Humans; Ligands; Models, Molecular; Protein Conformation; Quinazolines; Rats; Recombinant Proteins; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex.
Topics: Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin A; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; DNA Fragmentation; DNA-Binding Proteins; DNA, Neoplasm; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Activation; Enzyme Inhibitors; Growth Inhibitors; Humans; Macromolecular Substances; Protein Serine-Threonine Kinases; Quinazolines; Retinoblastoma-Binding Protein 1; Thiophenes; Thymidine; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured | 1999 |
The use of raltitrexed (tomudex) in a patient with 5-fluorouracil induced myocardial ischaemia.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Female; Fluorouracil; Humans; Middle Aged; Myocardial Ischemia; Quinazolines; Thiophenes; Thymidylate Synthase | 1999 |
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; Glutamates; Humans; Indoles; Isoindoles; Methotrexate; Ovarian Neoplasms; Quinazolines; Thiophenes; Transfection; Tumor Cells, Cultured | 1999 |
[The treatment of advanced colorectal carcinoma. New data emerging from the 23rd Congress of the European Society for Medical Oncology. Athens, November 1998].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Humans; Quinazolines; Radiotherapy, Adjuvant; Thiophenes | 1999 |
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Variable intrinsic sensitivity of human tumor cell lines to raltitrexed (Tomudex) and folylpolyglutamate synthetase activity.
Topics: Animals; Antimetabolites, Antineoplastic; Enzyme Inhibitors; Humans; Peptide Synthases; Quinazolines; Rats; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells.
Topics: Antimetabolites, Antineoplastic; Cell Count; Down-Regulation; Female; Floxuridine; Fluorouracil; HeLa Cells; Humans; Oligonucleotides, Antisense; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase; Transfection | 1999 |
Dimerization of mitochondrial Bax is associated with increased drug response in Bax-transfected A253 cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Squamous Cell; Cytochrome c Group; Dimerization; Dose-Response Relationship, Drug; Enzyme Activation; Head and Neck Neoplasms; Humans; Mitochondria; Neoplasm Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Thiophenes; Thymidylate Synthase; Transfection; Tumor Cells, Cultured | 1999 |
Involvement of bcl-2 and p21waf1 proteins in response of human breast cancer cell clones to Tomudex.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; Clone Cells; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Antibody Technique; Genes, p53; Humans; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Thiophenes; Thymidylate Synthase; Transfection; Tumor Cells, Cultured | 1999 |
Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
Topics: Biological Transport; Cell Division; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Growth Inhibitors; Humans; Inhibitory Concentration 50; Leukemia; Methotrexate; Peptide Synthases; Purines; Quinazolines; RNA, Messenger; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Drug-company decision to end cancer trial.
Topics: Advisory Committees; Antidotes; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Colonic Neoplasms; Control Groups; Drug Industry; Europe; Fluorouracil; Humans; Leucovorin; Multicenter Studies as Topic; Quinazolines; Research Subjects; Thiophenes | 1999 |
Characterisation of a synergistic interaction between a thymidylate synthase inhibitor, ZD1694, and a novel lipophilic topoisomerase I inhibitor karenitecin, BNP1100: mechanisms and clinical implications.
Topics: Antimetabolites, Antineoplastic; Camptothecin; Cell Division; Cell Survival; Colonic Neoplasms; DNA Damage; Drug Synergism; Enzyme Inhibitors; Humans; Quinazolines; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1999 |
Enzyme prodrug gene therapy: synergistic use of the herpes simplex virus-cellular thymidine kinase/ganciclovir system and thymidylate synthase inhibitors for the treatment of colon cancer.
Topics: Antiviral Agents; Bromodeoxyuridine; Colonic Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Fluorouracil; Ganciclovir; Genetic Therapy; Humans; Quinazolines; Simplexvirus; Thiophenes; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
The plasma pharmacokinetics and cerebrospinal fluid penetration of the thymidylate synthase inhibitor raltitrexed (Tomudex) in a nonhuman primate model.
Topics: Animals; Antimetabolites, Antineoplastic; Half-Life; Infusions, Intravenous; Macaca mulatta; Male; Metabolic Clearance Rate; Models, Biological; Quinazolines; Sensitivity and Specificity; Thiophenes; Thymidylate Synthase | 1999 |
Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
Topics: Blotting, Western; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Immunohistochemistry; Indoles; Inhibitory Concentration 50; Isoindoles; Methotrexate; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Quinazolines; Thiophenes; Treatment Outcome; Trimetrexate | 1999 |
Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Databases, Factual; Female; Fluorouracil; Geriatrics; Humans; Leucovorin; Male; Middle Aged; Palliative Care; Prospective Studies; Quality of Life; Quinazolines; Survival Analysis; Thiophenes | 1999 |
Safety of raltitrexed.
Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Colonic Neoplasms; Humans; Quinazolines; Thiophenes | 1999 |
Safety of raltitrexed.
Topics: Clinical Trials as Topic; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Quinazolines; Thiophenes | 1999 |
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.
Topics: Acid Anhydride Hydrolases; Antimetabolites, Antineoplastic; Deoxyribonucleotides; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Nucleoside-Diphosphate Kinase; Nucleoside-Triphosphatase; Pemetrexed; Quinazolines; Ribonucleotides; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1999 |
Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity.
Topics: Animals; Antimetabolites, Antineoplastic; Deoxyuridine; Diarrhea; Digestive System; Dose-Response Relationship, Drug; Folic Acid; Intestinal Mucosa; Intestine, Large; Intestine, Small; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Weight Loss | 2000 |
Modulation of RTX cytotoxicity by thymidine and dipyridamole in vitro: implications for chemotherapy.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Genes, p53; Humans; Phosphodiesterase Inhibitors; Quinazolines; Thiophenes; Thymidine; Tumor Cells, Cultured | 2000 |
Overexpression of Bax enhances antitumor activity of chemotherapeutic agents in human head and neck squamous cell carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Camptothecin; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Enzyme Inhibitors; Female; Head and Neck Neoplasms; Humans; Irinotecan; Mice; Mice, Nude; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells.
Topics: 3T3 Cells; Animals; Bone Marrow Cells; Carrier Proteins; Cell Death; DNA, Complementary; Drug Resistance; Drug Synergism; Equilibrative-Nucleoside Transporter 2; Female; Folic Acid Antagonists; Gene Transfer Techniques; Genetic Vectors; Glutamates; Guanine; Hematopoietic Stem Cells; Membrane Proteins; Mice; Mice, Inbred C57BL; Pemetrexed; Quinazolines; Retroviridae; Thioinosine; Thiophenes | 2000 |
Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Colonic Neoplasms; Enzyme Inhibitors; Flow Cytometry; Fluorouracil; Genes, bcl-2; Genes, p53; Humans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
[Absence of cross resistance between an irinotecan plus cisplatin combination and raltitrexed (ZD1694) in two patients with advanced colorectal cancer].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colorectal Neoplasms; Drug Resistance; Enzyme Inhibitors; Female; Humans; Irinotecan; Male; Middle Aged; Quinazolines; Thiophenes; Thymidylate Synthase | 2000 |
Murine cytomegalovirus stimulates cellular thymidylate synthase gene expression in quiescent cells and requires the enzyme for replication.
Topics: 3T3 Cells; Animals; Binding Sites; Carrier Proteins; Cell Cycle Proteins; DNA Replication; DNA-Binding Proteins; DNA, Viral; E2F Transcription Factors; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Immediate-Early Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muromegalovirus; Promoter Regions, Genetic; Quinazolines; Retinoblastoma-Binding Protein 1; Thiophenes; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Viral Proteins; Virus Replication | 2000 |
Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; DNA Damage; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Schedule-dependent interactions between raltitrexed and cisplatin in human carcinoma cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Humans; Neoplasms; Quinazolines; Thiophenes; Tumor Cells, Cultured | 2000 |
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carboplatin; Cell Division; Cisplatin; Docetaxel; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Quinazolines; Survival Rate; Taxoids; Thiophenes; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
A comparison of the effects of nine folate analogs on early and late murine hematopoietic progenitor cells in vitro.
Topics: Aminopterin; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Hematopoietic Stem Cells; Methotrexate; Mice; Mice, Inbred BALB C; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 2000 |
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Flow Cytometry; Fluorouracil; Glutamates; Guanine; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Mice; Mice, Inbred DBA; Microscopy, Confocal; Neoplasm Transplantation; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured; Up-Regulation | 2000 |
Fatal liver failure after the administration of raltitrexed for cancer chemotherapy: a report of two cases.
Topics: Aged; Antimetabolites, Antineoplastic; Fatal Outcome; Female; Humans; Liver Failure; Male; Middle Aged; Neoplasms; Quinazolines; Thiophenes | 2000 |
Raltitrexed, a novel folate-based thymidylate synthase inhibitor, for the treatment of acute leukemia: is this drug active against acute myelogenous leukemia?
Topics: Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Leukemia, Myeloid, Acute; Molecular Structure; Quinazolines; Thiophenes; Thymidylate Synthase | 2000 |
The thymidylate synthase inhibitor ZD1694 potently inhibits murine and human cytomegalovirus replication in quiescent fibroblasts.
Topics: Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; DNA, Viral; Fibroblasts; Ganciclovir; Humans; Inhibitory Concentration 50; Mice; Muromegalovirus; Polymerase Chain Reaction; Quinazolines; Thiophenes; Thymidylate Synthase; Virus Replication | 2000 |
Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Cell Division; Cell Line; Drug Interactions; Humans; Intestinal Mucosa; Intestine, Small; Leucovorin; Leukemia L1210; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Neutropenia; Polyglutamic Acid; Quinazolines; Thiophenes; Thrombocytopenia | 2000 |
Treatment of SW620 cells with Tomudex and oxaliplatin induces changes in 2-deoxy-D-glucose incorporation associated with modifications in glucose transport.
Topics: Antineoplastic Agents; Biological Transport; Cell Cycle; Colonic Neoplasms; Deoxyglucose; Enzyme Inhibitors; Flow Cytometry; Glucose; Humans; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tritium; Tumor Cells, Cultured | 2000 |
Raltitrexed-related pulmonary toxicity.
Topics: Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Dyspnea; Female; Humans; Lung Diseases; Quinazolines; Radiography, Thoracic; Thiophenes | 2000 |
Time-lapse video reveals immediate heterogeneity and heritable damage among human ileocecal carcinoma HCT-8 cells treated with raltitrexed (ZD1694).
Topics: Aged; Antimetabolites, Antineoplastic; Cell Division; Cell Lineage; Clone Cells; Humans; Ileal Neoplasms; Male; Microscopy, Video; Probability; Quinazolines; Thiophenes; Tumor Cells, Cultured | 2000 |
Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carrier Proteins; Cell Survival; Deoxycytidine; Equilibrative Nucleoside Transport Proteins; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Fluorouracil; Gemcitabine; Humans; Inhibitory Concentration 50; Pancreatic Neoplasms; Purine Nucleosides; Quinazolines; Thiophenes; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2000 |
The importance of p53-independent apoptosis in the intestinal toxicity induced by raltitrexed (ZD1694, Tomudex): genetic differences between BALB/c and DBA/2 mice.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Fluorouracil; Intestines; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mitosis; Quinazolines; Species Specificity; Thiophenes; Tumor Suppressor Protein p53 | 2000 |
Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells.
Topics: Animals; CD8-Positive T-Lymphocytes; Clonal Deletion; Enterotoxins; Fas Ligand Protein; fas Receptor; Folic Acid Antagonists; Growth Inhibitors; Injections, Intraperitoneal; Injections, Intravenous; Ligands; Lymphocyte Activation; Lymphocyte Depletion; Membrane Glycoproteins; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Nucleic Acid Synthesis Inhibitors; Quinazolines; Staphylococcus aureus; Superantigens; T-Lymphocyte Subsets; Thiophenes; Thymidine; Thymidylate Synthase | 2001 |
Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells.
Topics: Colonic Neoplasms; Enzyme Inhibitors; Growth Inhibitors; Humans; Oligoribonucleotides, Antisense; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2001 |
The anticytomegaloviral activity of raltitrexed is abrogated in quiescent mouse fibroblasts that overexpress thymidylate synthase.
Topics: Animals; Antiviral Agents; Cell Line; Cytomegalovirus; Enzyme Inhibitors; Mice; Quinazolines; Thiophenes; Thymidylate Synthase; Virus Replication | 2001 |
Influence of cytokines, monoclonal antibodies and chemotherapeutic drugs on epithelial cell adhesion molecule (EpCAM) and LewisY antigen expression.
Topics: Adjuvants, Immunologic; Antibodies, Monoclonal; Antigens, Neoplasm; Antineoplastic Agents; Camptothecin; Cell Adhesion Molecules; Cytokines; Epithelial Cell Adhesion Molecule; Fluorouracil; Granulocyte-Macrophage Colony-Stimulating Factor; HT29 Cells; Humans; Interferons; Interleukins; Irinotecan; Lewis Blood Group Antigens; Macrophage Colony-Stimulating Factor; Mitomycin; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation | 2001 |
Schedule-dependent synergism and antagonism between raltitrexed ("Tomudex") and methotrexate in human colon cancer cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Methotrexate; Quinazolines; Thiophenes; Tumor Cells, Cultured | 2001 |
[Raltitrexed-induced skin reaction].
Topics: Aged; Antimetabolites, Antineoplastic; Drug Eruptions; Humans; Male; Quinazolines; Thiophenes | 2000 |
Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells.
Topics: Animals; Antimetabolites, Antineoplastic; Base Sequence; Cell Line; Cricetinae; DNA, Complementary; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Fluorouracil; Folic Acid Antagonists; Gene Expression; Genetic Vectors; Hematopoietic Stem Cells; Humans; Mice; Molecular Sequence Data; Myeloid Progenitor Cells; Polymerase Chain Reaction; Quinazolines; Retroviridae; Sequence Homology, Nucleic Acid; Thiophenes; Thymidylate Synthase; Transfection | 2001 |
Schedule-dependent interaction between raltitrexed and 5-fluorouracil in human colon cancer cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluorouracil; Humans; Quinazolines; Thiophenes; Tumor Cells, Cultured | 2000 |
Synergistic efficacy of 3n-butyrate and 5-fluorouracil in human colorectal cancer xenografts via modulation of DNA synthesis.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers; Butyrates; Cell Differentiation; Cell Division; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); DNA; Drug Synergism; Female; Fluorouracil; Glucose; Humans; Liver Neoplasms; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Organoplatinum Compounds; Oxaliplatin; Oxidoreductases; Protein-Tyrosine Kinases; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase; Transplantation, Heterologous | 2001 |
Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Cysteine; Deoxyuracil Nucleotides; Drug Design; Enzyme Inhibitors; Escherichia coli; Humans; Models, Molecular; Protein Binding; Protein Structure, Secondary; Quinazolines; Sequence Deletion; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 2001 |
[Non-alcoholic steatohepatitis with cirrhosis after raltitrexed administration].
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Disease Progression; Drug Monitoring; Fat Necrosis; Fatty Liver; Female; Humans; Liver Cirrhosis; Liver Function Tests; Middle Aged; Quinazolines; Rectal Neoplasms; Thiophenes; Thymidylate Synthase | 2001 |
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase | 2001 |
Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.
Topics: Binding Sites; Computer Simulation; Crystallization; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Ligands; Macromolecular Substances; Models, Molecular; Protein Conformation; Quinazolines; Thiophenes; Thymidylate Synthase | 2001 |
Safe administration of irinotecan, oxaliplatin and raltitrexed in a DPD-deficient patient with metastatic colon cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxidoreductases; Quinazolines; Thiophenes | 2001 |
Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells.
Topics: Adenoviridae; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Base Pair Mismatch; Blotting, Western; Bromodeoxyuridine; Cell Division; Dacarbazine; DNA Repair; DNA Replication; Enzyme Inhibitors; Fluorouracil; Gene Deletion; Genetic Vectors; Humans; Jurkat Cells; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Transport; Quinazolines; Temozolomide; Thiophenes; Transduction, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
The impact of p53 status on cellular sensitivity to antifolate drugs.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Mutational Analysis; DNA, Neoplasm; Dose-Response Relationship, Drug; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Genotype; Glutamates; Guanine; Humans; Methotrexate; Mutation; Pemetrexed; Quinazolines; Sensitivity and Specificity; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors.
Topics: Blotting, Northern; Blotting, Western; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization, Fluorescence; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-yes; Quinazolines; RNA, Messenger; src-Family Kinases; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2001 |
A phase I study of raltitrexed (Tomudex) combined with carmofur in metastatic colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Diseases; Hematologic Diseases; Humans; Male; Maximum Tolerated Dose; Middle Aged; Nervous System Diseases; Quinazolines; Salvage Therapy; Thiophenes; Treatment Outcome | 2001 |
Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies.
Topics: Blotting, Northern; Blotting, Western; Camptothecin; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cisplatin; Cyclin A; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Humans; Irinotecan; Neoplasms; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Protein Serine-Threonine Kinases; Quinazolines; RNA, Messenger; Tetracycline; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2001 |
Thymidylate synthase inhibition induces p53 dependent and independent cell death.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Caspases; Colonic Neoplasms; DNA Damage; Enzyme Inhibitors; Fas Ligand Protein; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Membrane Glycoproteins; Pemetrexed; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
[Irinotecan and tomudex in the treatment of patients with advanced cancer of the large intestine].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Female; Humans; Irinotecan; Male; Middle Aged; Quinazolines; Rectal Neoplasms; Thiophenes; Time Factors | 2001 |
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Combined chemotherapy trials require combined pharmacogenetic approaches.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Enzyme Inhibitors; Humans; Irinotecan; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Quinazolines; Thiophenes | 2002 |
Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Bromodeoxyuridine; Carrier Proteins; Cell Survival; Colonic Neoplasms; Dipyridamole; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Humans; Membrane Proteins; Nucleoside Transport Proteins; Quinazolines; Thioinosine; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Baseline quality of life predicts survival in patients with advanced colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Agents; Cohort Studies; Colorectal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Prognosis; Prospective Studies; Quality of Life; Quinazolines; Randomized Controlled Trials as Topic; Surveys and Questionnaires; Thiophenes | 2002 |
Raltitrexed as monochemotherapy induces a statistically significant increase in platelet count.
Topics: Aged; Antimetabolites, Antineoplastic; Blood Platelets; Colorectal Neoplasms; Hemoglobins; Humans; Middle Aged; Platelet Count; Quinazolines; Thiophenes | 2002 |
Conjoint analysis of a new Chemotherapy: willingness to pay and preference for the features of raltitrexed versus standard therapy in advanced Colorectal Cancer.
Topics: Adult; Antimetabolites, Antineoplastic; Australia; Colorectal Neoplasms; Data Collection; Female; Humans; Male; Middle Aged; Models, Economic; Quinazolines; Surveys and Questionnaires; Thiophenes | 2002 |
[The rare manifestation of soft tissue metastasis in colorectal cancer].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Fatal Outcome; Humans; Male; Quinazolines; Soft Tissue Neoplasms; Thiophenes | 2002 |
Ex vivo stimulation of renal transport of the cytostatic drugs methotrexate, cisplatin, topotecan (Hycamtin) and raltitrexed (Tomudex) by dexamethasone, T3 and EGF in intact human and rat kidney tissue and in human renal cell carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Carcinoma, Renal Cell; Cisplatin; Dexamethasone; Epidermal Growth Factor; Female; Glucocorticoids; Humans; Kidney; Kidney Neoplasms; Methotrexate; Quinazolines; Rats; Rats, Wistar; Thiophenes; Topotecan; Triiodothyronine | 2002 |
Second-Line Treatment of Advanced Colorectal Cancer with a Biweekly Oxaliplatin plus Irinotecan Combination Regimen.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Irinotecan; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Quinazolines; Thiophenes; Treatment Failure | 2002 |
Raltitrexed treatment promotes systemic inflammatory reaction in patients with colorectal carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; C-Reactive Protein; Colorectal Neoplasms; Cross-Sectional Studies; Fatigue; Female; Fever; Fluorouracil; Humans; Inflammation; Interleukin-6; Liver Neoplasms; Longitudinal Studies; Lung Neoplasms; Male; Middle Aged; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Necrosis Factor-alpha | 2002 |
Raltitrexed (Tomudex): an alternative choice in patients intolerant to 5-fluorouracil.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Antimetabolites, Antineoplastic; Colonic Diseases; Drug Hypersensitivity; Female; Fluorouracil; Humans; Leucovorin; Lymphatic Metastasis; Middle Aged; Quinazolines; Thiophenes; Thymidylate Synthase | 2002 |
[New therapeutic options for mesothelioma].
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Doxorubicin; Folic Acid Antagonists; France; Gemcitabine; Humans; Mesothelioma; Mitomycin; Neoplasm Staging; Patient Selection; Pneumonectomy; Prognosis; Quinazolines; Radiotherapy, Adjuvant; Risk Factors; Survival Analysis; Thiophenes; Treatment Outcome; Vindesine | 2002 |
Pharmacokinetics studies and toxicity profile of raltitrexed used by intraperitoneal route in normothermia in a pig model.
Topics: Animals; Antimetabolites, Antineoplastic; Body Temperature; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Injections, Intraperitoneal; Models, Statistical; Neoplasms; Quinazolines; Swine; Thiophenes; Time Factors | 2003 |
Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Survival; Comet Assay; DNA Damage; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Lung Neoplasms; N-Glycosyl Hydrolases; Quinazolines; Thiophenes; Thymidylate Synthase; Transfection; Tumor Cells, Cultured; Uracil-DNA Glycosidase | 2003 |
Severe liver dysfunction after raltitrexed administration in an HCV-positive colorectal cancer patient.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Chemical and Drug Induced Liver Injury; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver Function Tests; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes; Viremia | 2003 |
A "combination oligonucleotide" antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance.
Topics: Antineoplastic Agents; Cell Division; Down-Regulation; Drug Resistance, Neoplasm; Female; Fluorouracil; HeLa Cells; Humans; Neoplasms; Oligodeoxyribonucleotides, Antisense; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase | 2003 |
[Severe acute cytomegalovirus colitis after administration of irinotecan and raltitrexed chemotherapy].
Topics: Acute Disease; Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Camptothecin; Colitis; Cytomegalovirus Infections; Ganciclovir; Humans; Immunocompromised Host; Irinotecan; Male; Quinazolines; Rectal Neoplasms; Sigmoid Neoplasms; Thiophenes | 2003 |
Treatment of advanced gastric cancer: where we are in 2003.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease Progression; Humans; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Randomized Controlled Trials as Topic; Stomach Neoplasms; Survival Rate; Thiophenes; Treatment Outcome | 2003 |
Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cecal Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Folic Acid; Glutamates; Hematinics; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Ileal Neoplasms; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Pyrimidines; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured | 2003 |
Intestinal permeability in colorectal cancer patients treated by raltitrexed or irinotecan.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Female; Humans; Intestinal Mucosa; Irinotecan; Male; Middle Aged; Permeability; Quinazolines; Thiophenes | 2003 |
A new nonlinear mixture response surface paradigm for the study of synergism: a three drug example.
Topics: Adenocarcinoma; Algorithms; Antimetabolites; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Humans; Hydroxymethyl and Formyl Transferases; Intestinal Neoplasms; Models, Biological; Nonlinear Dynamics; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 2003 |
The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Models, Chemical; Neoplasms; Pemetrexed; Quinazolines; Receptors, Cell Surface; Thiophenes; Time Factors | 2004 |
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Cell Division; Drug Resistance, Neoplasm; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Membrane Transport Proteins; Ornithine; Pemetrexed; Polyglutamic Acid; Pterins; Quinazolines; Reduced Folate Carrier Protein; Thiophenes | 2004 |
p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.
Topics: Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Stability; Fibrosarcoma; Folic Acid Antagonists; Humans; Methotrexate; Neoplastic Stem Cells; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53 | 2004 |
Involvement of base excision repair in response to therapy targeted at thymidylate synthase.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Cell Line; Cell Survival; DNA Polymerase beta; DNA Repair; DNA-Binding Proteins; Gene Deletion; Ligands; Mice; Protein Binding; Quinazolines; Thiophenes; Thymidylate Synthase; X-ray Repair Cross Complementing Protein 1 | 2004 |
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Blotting, Northern; Carrier Proteins; Cell Line; Cell Line, Tumor; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Ions; Kinetics; Membrane Transport Proteins; Methotrexate; Pemetrexed; Protein Isoforms; Quinazolines; Receptors, Cell Surface; Reduced Folate Carrier Protein; RNA; Thiophenes; Time Factors; Transfection; Trimetrexate | 2004 |
Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ mice.
Topics: Adenoma; Adenomatous Polyposis Coli Protein; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Epithelial Cells; Female; Fluorouracil; Intestinal Neoplasms; Loss of Heterozygosity; Male; Mice; Mice, Inbred C57BL; Quinazolines; Thiophenes; Tumor Burden | 2004 |
DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.
Topics: Adenosine Triphosphatases; Base Pair Mismatch; Cell Cycle; Cell Line, Tumor; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Enzyme Activation; G2 Phase; Humans; MutS Homolog 2 Protein; MutS Homolog 3 Protein; Proto-Oncogene Proteins; Pyrimidines; Quinazolines; Thiophenes | 2005 |
A study of the effect of temperature on the pharmacokinetic profile of raltitrexed administered by intraperitoneal route in the rat.
Topics: Animals; Antimetabolites, Antineoplastic; Body Temperature; Heating; Injections, Intraperitoneal; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Thiophenes | 2005 |
Synergistic antitumor activity of capecitabine in combination with irinotecan.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Irinotecan; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes | 2005 |
Importance of preclinical investigations of the integration of capecitabine into polychemotherapy regimens.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Irinotecan; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes | 2005 |
New drugs for colorectal cancer (irinotecan, oxaliplatin, raltitrexed) meet expectations in routine practice: a single center's experience before and after their introduction.
Topics: Age Factors; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Evidence-Based Medicine; Female; Humans; Irinotecan; Male; Medical Oncology; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Prognosis; Quinazolines; Retrospective Studies; Survival Analysis; Thiophenes; Treatment Outcome | 2005 |
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Death; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; DNA, Single-Stranded; Drug Screening Assays, Antitumor; Fluorodeoxyuridylate; Fluorouracil; Leukemia P388; Mice; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Topoisomerase I Inhibitors | 2005 |
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
Topics: Antimetabolites; Colonic Neoplasms; DNA Damage; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homeostasis; Humans; Indoles; Isoindoles; Quinazolines; Thiophenes; Trifluridine; Tumor Cells, Cultured | 2006 |
Study on brain targeting of raltitrexed following intranasal administration in rats.
Topics: Administration, Intranasal; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Biological Availability; Brain; Injections, Intravenous; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Thiophenes; Tissue Distribution | 2006 |
Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency.
Topics: Animals; Apoptosis; Cell Line; Cells, Cultured; DNA Damage; DNA Polymerase beta; DNA Repair; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblasts; Humans; Mice; Poly Adenosine Diphosphate Ribose; Quinazolines; Sister Chromatid Exchange; Thiophenes; Thymidylate Synthase; Time Factors; Uracil; Uracil-DNA Glycosidase | 2005 |
Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Apoptosis; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Drug Synergism; fas Receptor; Fluorouracil; HCT116 Cells; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Phosphorylation; Quinazolines; RNA, Messenger; STAT1 Transcription Factor; Thiophenes; Tumor Suppressor Protein p53; Up-Regulation | 2005 |
Quantitative structure-pharmacokinetic relationships for drug clearance by using statistical learning methods.
Topics: Adult; Algorithms; Allopurinol; Antipyrine; Carbidopa; Chlorpheniramine; Fendiline; Humans; Male; Pharmaceutical Preparations; Pharmacokinetics; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Quinazolines; Reproducibility of Results; Statistics as Topic; Thiophenes; Tocainide | 2006 |
Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.
Topics: Antimetabolites, Antineoplastic; Computer Simulation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Models, Chemical; Purines; Quinazolines; Signal Transduction; Tetrahydrofolates; Thiophenes; Thymidine Monophosphate | 2006 |
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Topics: Amino Acid Substitution; Antineoplastic Agents; Arginine; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Glutamates; Glycine; Guanine; Humans; Leucovorin; Methotrexate; Mutation; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Purines; Pyrimidines; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase | 2006 |
An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed.
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Cell Line, Tumor; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; HT29 Cells; Humans; Immunoglobulin Fab Fragments; Injections, Intravenous; Mice; Mice, Nude; Quinazolines; Reproducibility of Results; Thiophenes; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Xenograft Model Antitumor Assays | 2007 |
Severe enteropathy associated with raltitrexed and oxaliplatin chemotherapy: report of two patients experiencing this rare, potentially lethal gastrointestinal adverse event.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Colonoscopy; Colorectal Neoplasms; Diabetes Complications; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Enterocolitis; Fatal Outcome; Female; Gastrointestinal Diseases; Humans; Lung Neoplasms; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2006 |
Raltitrexed and pemetrexed studies in mesothelioma have not shown improved quality of life nor prolonged survival compared with effective pleurodesis with thoracoscopic talc poudrage.
Topics: Cisplatin; Clinical Trials as Topic; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Pleural Neoplasms; Pleurodesis; Quality of Life; Quinazolines; Talc; Thiophenes; Treatment Outcome | 2006 |
Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Fluorouracil; Humans; NF-kappa B; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2007 |
Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Disease Progression; Fluorouracil; Gene Deletion; Genotype; Heterozygote; Humans; Models, Statistical; Mutation; Polymorphism, Genetic; Quinazolines; Sequence Analysis, DNA; Thiophenes; Thymidylate Synthase; Treatment Outcome | 2007 |
Combination silencer RNA (siRNA) targeting Bcl-2 antagonizes siRNA against thymidylate synthase in human tumor cell lines.
Topics: Cell Line, Tumor; Cell Proliferation; Docetaxel; Floxuridine; G1 Phase; Humans; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Quinazolines; RNA, Messenger; RNA, Small Interfering; Taxoids; Thiophenes; Thymidylate Synthase | 2007 |
Determination of raltitrexed in human plasma by high performance liquid chromatography-electrospray ionization-mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Humans; Molecular Structure; Quinazolines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Thiophenes | 2007 |
Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2007 |
Synergistic antitumour effect of raltitrexed and 5-fluorouracil plus folinic acid combination in human cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; Head and Neck Neoplasms; Humans; Inhibitory Concentration 50; Leucovorin; Quinazolines; Thiophenes | 2007 |
Antisense targeting of thymidylate synthase (TS) mRNA increases TS gene transcription and TS protein: effects on human tumor cell sensitivity to TS enzyme-inhibiting drugs.
Topics: Antimetabolites, Antineoplastic; Cell Cycle; Cell Proliferation; Gene Targeting; HeLa Cells; Humans; Oligonucleotides, Antisense; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase; Transcription, Genetic; Tumor Cells, Cultured | 2007 |
Therapy of colon carcinoma: an oncology perspective. Interview with Piotr M. Czaykowski by Paul C. Adams.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Carcinoembryonic Antigen; Carcinoma; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Irinotecan; Quinazolines; Rectal Neoplasms; Thiophenes | 2007 |
Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.
Topics: Blotting, Western; Capecitabine; Cell Cycle; Cell Line; Deoxycytidine; DNA; DNA Primers; DNA Repair; Fluorouracil; Green Fluorescent Proteins; Humans; Mass Spectrometry; Quinazolines; Thiophenes; Thymidylate Synthase; Uracil; Uracil-DNA Glycosidase | 2008 |
In Australia, patients and government at odds over mesothelioma treatment costs.
Topics: Abdominal Neoplasms; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asbestos; Australia; Canada; Carcinogens; Cisplatin; Cost-Benefit Analysis; Environmental Exposure; Glutamates; Government; Guanine; Health Care Costs; Humans; Incidence; Lobbying; Lung Neoplasms; Mesothelioma; Patient Advocacy; Pemetrexed; Quinazolines; Thiophenes; Thoracic Neoplasms; United Kingdom | 2007 |
Adjuvant therapy with raltitrexed in patients with colorectal cancer intolerant of 5-fluorouracil: British Columbia Cancer Agency experience.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Humans; Male; Middle Aged; Quinazolines; Retrospective Studies; Thiophenes | 2007 |
Chronic myeloid leukemia following the treatment of rectal adenocarcinoma.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Deoxycytidine; Fluorouracil; Fusion Proteins, bcr-abl; Humans; In Situ Hybridization, Fluorescence; Irinotecan; Leucovorin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Male; Neoplasms, Second Primary; Organoplatinum Compounds; Oxaliplatin; Philadelphia Chromosome; Quinazolines; Rectal Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes | 2008 |
Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase.
Topics: Base Sequence; Blotting, Southern; Cell Line; Chromosomes, Human; Crossing Over, Genetic; DNA Breaks, Double-Stranded; Fibroblasts; Folic Acid Antagonists; Gene Conversion; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Quinazolines; Recombination, Genetic; Substrate Specificity; Thiophenes; Thymidylate Synthase | 2008 |
A case of relapsing secondary bladder adenocarcinoma after right colonic cancer.
Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cecal Neoplasms; Cetuximab; Chemotherapy, Adjuvant; Colectomy; Female; Fluorouracil; Humans; Immunohistochemistry; Irinotecan; Leucovorin; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Organoplatinum Compounds; Quinazolines; Retroperitoneal Neoplasms; Sacrum; Thiophenes; Tomography, X-Ray Computed; Urinary Bladder Neoplasms | 2008 |
DNA damage and homologous recombination signaling induced by thymidylate deprivation.
Topics: Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Flow Cytometry; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Nucleotides; Phosphorylation; Quinazolines; Rad51 Recombinase; Recombination, Genetic; Replication Protein A; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase | 2008 |
Chiral separation of raltitrexed by cyclodextrin-modified micellar electrokinetic chromatography.
Topics: beta-Cyclodextrins; Chromatography, Micellar Electrokinetic Capillary; Electrochemistry; Electrolytes; Hydrogen-Ion Concentration; Molecular Conformation; Quinazolines; Sodium Dodecyl Sulfate; Stereoisomerism; Temperature; Thiophenes; Time Factors | 2009 |
Clinical study of combined use of tomudex (raltitrexed) and xeloda (capecitabine) as first-line treatment for patients with metastasizing colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Disease Progression; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Quinazolines; Survival Rate; Thiophenes; Treatment Outcome | 2008 |
Trimodality therapy with induction chemotherapy followed by extrapleural pneumonectomy and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Glutamates; Guanine; Humans; Male; Mesothelioma; Middle Aged; Neoadjuvant Therapy; Pemetrexed; Pleural Neoplasms; Pneumonectomy; Quinazolines; Radiotherapy, Adjuvant; Remission Induction; Retrospective Studies; Thiophenes; Vinblastine; Vinorelbine | 2009 |
Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Growth Processes; Cell Line, Tumor; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; HT29 Cells; Humans; Hydroxamic Acids; Leucovorin; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Suppressor Protein p53; Vorinostat | 2009 |
Successful and well-tolerated second line therapy with cetuximab, irinotecan, and raltitrexed in progressive liver disease due to metastatic colon cancer.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colonic Neoplasms; Humans; Irinotecan; Liver Diseases; Liver Neoplasms; Male; Quinazolines; Thiophenes | 2008 |
Acute coronary syndrome associated with continuous 5-Fluorouracil infusion in a patient with metastatic colorectal cancer-a case report with a discussion on this clinical dilemma.
Topics: Acute Coronary Syndrome; Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colorectal Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Thiophenes | 2009 |
Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer: a retrospective study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Retrospective Studies; Thiophenes | 2010 |
Synthesis and biological activity of raltitrexed-carrier conjugates.
Topics: Animals; Apoptosis; Cattle; Cell Cycle; Cell Line, Tumor; Dextrans; Humans; Hydrogen-Ion Concentration; Mice; Muramidase; Neoplasm Transplantation; Quinazolines; Serum Albumin, Bovine; Thiophenes | 2010 |
Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy.
Topics: Adult; Aged; Female; Fluorouracil; Gene Expression Profiling; Genetic Association Studies; Genotype; Humans; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Neoadjuvant Therapy; Neoplasm Staging; Polymorphism, Single Nucleotide; Quinazolines; Rectal Neoplasms; Thiophenes; Treatment Outcome | 2011 |
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Male; Methotrexate; MicroRNAs; Middle Aged; Nuclear Proteins; Osteosarcoma; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Transfection; Ubiquitin-Protein Ligases | 2010 |
Oxaliplatin plus dual inhibition of thymidilate synthase during preoperative pelvic radiotherapy for locally advanced rectal carcinoma: long-term outcome.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Diarrhea; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Proteins; Neoplasm Staging; Neutropenia; Organoplatinum Compounds; Oxaliplatin; Postoperative Complications; Preoperative Care; Prognosis; Quinazolines; Radiotherapy Dosage; Rectal Neoplasms; Remission Induction; Thiophenes; Thymidylate Synthase; Treatment Outcome; Vitamin B Complex | 2011 |
Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos.
Topics: Animals; Base Sequence; Embryo, Nonmammalian; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Protein Binding; Protein Biosynthesis; Protein Stability; Quinazolines; RNA Stability; RNA, Messenger; Thiophenes; Thymidylate Synthase; Time Factors; Zebrafish | 2010 |
Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.
Topics: Amino Acid Motifs; Casein Kinase II; Circular Dichroism; Deoxyuracil Nucleotides; Diphosphonates; Humans; Ligands; Mutation; Phosphorylation; Protein Binding; Protein Structure, Secondary; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 2011 |
Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase.
Topics: Biomarkers; Cell Line; Checkpoint Kinase 1; DNA Glycosylases; DNA Repair; Enzyme Inhibitors; Folic Acid Antagonists; Histones; Humans; Methotrexate; Nucleic Acid Synthesis Inhibitors; Phenotype; Protein Kinases; Quinazolines; Thiophenes; Thymidylate Synthase | 2010 |
Thiothymidine combined with UVA as a potential novel therapy for bladder cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; DNA Damage; Female; Humans; Quinazolines; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Thiophenes; Thymidine; Ultraviolet Therapy; Urinary Bladder Neoplasms | 2011 |
Affinity characterization-mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution.
Topics: Binding Sites; DNA Primase; Kinetics; Ligands; Mass Spectrometry; Protein Denaturation; Proteins; Quinazolines; Solutions; Structure-Activity Relationship; Temperature; Thiophenes; Thymidylate Synthase | 2011 |
Raltitrexed plus cisplatin is cost-effective compared with pemetrexed plus cisplatin in patients with malignant pleural mesothelioma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cost-Benefit Analysis; Glutamates; Guanine; Health Care Costs; Humans; Mesothelioma; Pemetrexed; Pleural Neoplasms; Quality-Adjusted Life Years; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes | 2012 |
Thymidylate synthase mRNA levels in plasma and tumor as potential predictive biomarkers for raltitrexed sensitivity in gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Female; Humans; Male; Middle Aged; Quinazolines; RNA, Messenger; Stomach Neoplasms; Thiophenes; Thymidylate Synthase | 2012 |
Influence of resistance to 5-fluorouracil and tomudex on [18F]‑FDG incorporation, glucose transport and hexokinase activity.
Topics: 3-O-Methylglucose; Antimetabolites, Antineoplastic; Biological Transport; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Fluorodeoxyglucose F18; Fluorouracil; Glucose; Hexokinase; Humans; Quinazolines; Radiopharmaceuticals; Thiophenes | 2012 |
Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Humans; Models, Molecular; Molecular Dynamics Simulation; Protein Processing, Post-Translational; Quinazolines; Thiophenes; Thymidylate Synthase; Tyrosine | 2013 |
CEA fluctuation during a single fluorouracil-based chemotherapy cycle for metastatic colorectal cancer.
Topics: Adult; Aged; Biomarkers, Tumor; Carcinoembryonic Antigen; Colorectal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Quinazolines; Thiophenes; Tomography, X-Ray Computed | 2013 |
Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration.
Topics: Anti-HIV Agents; Base Sequence; CD4-Positive T-Lymphocytes; Deoxyuracil Nucleotides; DNA Glycosylases; DNA, Viral; Enzyme Inhibitors; Gene Knockdown Techniques; HIV-1; Host-Pathogen Interactions; HT29 Cells; Humans; Immunity, Innate; Macrophages; Models, Biological; Mutation; Quinazolines; Reverse Transcription; Thiophenes; Thymidine; Thymidylate Synthase; Virion; Virus Integration | 2013 |
[Purification and activity evaluation of methionine synthase].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Electrophoresis, Polyacrylamide Gel; Folic Acid Antagonists; Liver; Male; Methotrexate; Quinazolines; Rats; Rats, Wistar; Tetrahydrofolates; Thiophenes | 2012 |
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Monitoring; Folic Acid Antagonists; Hot Temperature; Humans; Kidney; Ligands; Liver; Molecular Targeted Therapy; Pharmaceutical Preparations; Protein Binding; Protein Stability; Proteins; Quinazolines; Thiophenes; Tissue Distribution | 2013 |
Methotrexate analogues display enhanced inhibition of TNF-α production in whole blood from RA patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; Ornithine; Pterins; Quinazolines; T-Lymphocytes; Thiophenes; Trimetrexate; Tumor Necrosis Factor-alpha | 2014 |
[Pharmacokinetics behavior of raltitrexed in rats after single injected with astragali radix].
Topics: Animals; Antineoplastic Agents; Astragalus Plant; Chromatography, High Pressure Liquid; Drug Interactions; Drugs, Chinese Herbal; Female; Humans; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Thiophenes | 2013 |
Intestinal absorption of raltitrexed and evaluation of the effects of absorption enhancers.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acrylic Resins; Algorithms; Animals; Antimetabolites, Antineoplastic; ATP-Binding Cassette Transporters; Biological Availability; Caco-2 Cells; Decanoic Acids; Deoxycholic Acid; Excipients; Folic Acid; Humans; Intestinal Absorption; Male; Pantoprazole; Probenecid; Quinazolines; Rats; Rats, Wistar; Thiophenes; Verapamil | 2013 |
TS mRNA levels can predict pemetrexed and raltitrexed sensitivity in colorectal cancer.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Female; Fluorouracil; Glutamates; Guanine; Humans; Immunohistochemistry; Male; Middle Aged; Pemetrexed; Predictive Value of Tests; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase | 2014 |
Final results of Australasian Gastrointestinal Trials Group ARCTIC study: an audit of raltitrexed for patients with cardiac toxicity induced by fluoropyrimidines.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Substitution; Fluorouracil; Heart Diseases; Humans; Irinotecan; Middle Aged; Quinazolines; Thiophenes | 2014 |
Efficacy and safety of raltitrexed combinations with uracil- tegafur or mitomycin C as salvage treatment in advanced colorectal cancer patients: a multicenter study of Anatolian Society of Medical Oncology (ASMO).
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Female; Folic Acid Antagonists; Humans; Male; Middle Aged; Mitomycin; Neoplasm Metastasis; Quinazolines; Retrospective Studies; Salvage Therapy; Tegafur; Thiophenes; Treatment Outcome; Young Adult | 2014 |
Raltitrexed induces mitochondrial‑mediated apoptosis in SGC7901 human gastric cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cytochromes c; G1 Phase Cell Cycle Checkpoints; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oligopeptides; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Thiophenes; Thymidylate Synthase | 2014 |
Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Deoxyuracil Nucleotides; DNA Damage; Embryo, Mammalian; Female; Folic Acid Antagonists; Gestational Age; Histones; Injections, Intraperitoneal; Male; Mice, Inbred C57BL; Neural Tube Defects; Phosphorylation; Pregnancy; Protein Subunits; Quinazolines; Replication Protein A; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase | 2015 |
[Pharmacokinetics behavior of raltitrexed in rats after repeatedly injected with Huangqi injection].
Topics: Animals; Drugs, Chinese Herbal; Female; Injections; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Thiophenes | 2014 |
The role of raltitrexed/cisplatin with concurrent radiation therapy in treating advanced cervical cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Female; Follow-Up Studies; Humans; Middle Aged; Quinazolines; Survival Rate; Thiophenes; Treatment Outcome; Uterine Cervical Neoplasms | 2014 |
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.
Topics: Folic Acid Antagonists; Glycine Hydroxymethyltransferase; Humans; Methotrexate; Molecular Docking Simulation; Quinazolines; Tetrahydrofolates; Thiophenes | 2015 |
[Interstitial lung disease induced by raltitrexed-oxaliplatin based chemotherapy for colorectal cancer: a case report].
Topics: Aged; Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Humans; Lung Diseases, Interstitial; Male; Organoplatinum Compounds; Oxaliplatin; Prednisone; Quinazolines; Thiophenes | 2015 |
Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis.
Topics: Cell Line, Tumor; Endocytosis; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Pemetrexed; Proton-Coupled Folate Transporter; Quinazolines; Reduced Folate Carrier Protein; Thiophenes | 2015 |
Functional Identification of Target by Expression Proteomics (FITExP) reveals protein targets and highlights mechanisms of action of small molecule drugs.
Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Computational Biology; Doxorubicin; Drug Discovery; Fluorouracil; HCT116 Cells; Humans; Methotrexate; Paclitaxel; Proteome; Proteomics; Quinazolines; Small Molecule Libraries; Thiophenes | 2015 |
Clinical outcomes of elderly patients receiving neoadjuvant chemoradiation for locally advanced rectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemoradiotherapy; Chemotherapy, Adjuvant; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Quinazolines; Rectal Neoplasms; Retrospective Studies; Survival Rate; Thiophenes; Young Adult | 2015 |
Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Proliferation; Cyclin A; Cyclin-Dependent Kinase 2; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Genes, p16; Genes, p53; Hep G2 Cells; Humans; Liver Neoplasms; Quinazolines; Resting Phase, Cell Cycle; S Phase; Thiophenes | 2016 |
Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed.
Topics: Amino Acid Sequence; Antimetabolites, Antineoplastic; Binding Sites; Crystallography, X-Ray; Herpesvirus 8, Human; Ligands; Models, Molecular; Molecular Structure; Nucleoside-Phosphate Kinase; Quinazolines; Sequence Homology, Amino Acid; Thiophenes | 2016 |
Hepatic artery infusion with raltitrexed or 5-fluorouracil for colorectal cancer liver metastasis.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Retrospective Studies; Thiophenes; Time Factors; Treatment Outcome | 2017 |
Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.
Topics: 2,4-Dichlorophenoxyacetic Acid; Acridines; Adenosine Triphosphate; Animals; Biological Transport; Blood-Brain Barrier; Brain; Central Nervous System; Cyclic GMP; Humans; Kinetics; Male; Methotrexate; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Ochratoxins; Pravastatin; Quinazolines; Quinolines; Tetrahydroisoquinolines; Thiophenes; Uric Acid | 2017 |
A study of peritoneal metastatic xenograft model of colorectal cancer in the treatment of hyperthermic intraperitoneal chemotherapy with Raltitrexed.
Topics: Absorption, Physiological; Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma; Colorectal Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Half-Life; Hot Temperature; Humans; Hyperthermia, Induced; Infusions, Parenteral; Male; Mice, Nude; Peritoneal Neoplasms; Quinazolines; Random Allocation; Thiophenes; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
Topics: Allosteric Site; Amino Acid Substitution; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Enzyme Activation; Enzyme Stability; Folic Acid Antagonists; Humans; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Peptide Fragments; Protein Conformation; Protein Folding; Quinazolines; Recombinant Proteins; Thiophenes; Thymidylate Synthase | 2017 |
Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach.
Topics: Antineoplastic Agents; Catalytic Domain; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Escherichia coli; Humans; Molecular Docking Simulation; Mutation; Pregnadienes; Protein Conformation; Quinazolines; Thiophenes; Thymidylate Synthase | 2018 |
Molecular docking to Toxoplasma gondii thymidylate synthase-dihydrofolate reductase and efficacy of raltitrexed in infected mice.
Topics: Animals; Antimetabolites, Antineoplastic; Humans; Male; Mice; Molecular Docking Simulation; Multienzyme Complexes; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Toxoplasma; Toxoplasmosis, Animal | 2018 |
Transarterial embolization and low-dose continuous hepatic arterial infusion chemotherapy with oxaliplatin and raltitrexed for hepatocellular carcinoma with major portal vein tumor thrombus.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Catheters; Chemoembolization, Therapeutic; Female; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Portal Vein; Quinazolines; Retrospective Studies; Survival Rate; Thiophenes; Thrombosis; Treatment Outcome | 2018 |
Nucleoside Analogue-Based Supramolecular Nanodrugs Driven by Molecular Recognition for Synergistic Cancer Therapy.
Topics: Animals; Antineoplastic Agents; Clofarabine; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Mice, Inbred BALB C; Mice, Nude; Molecular Dynamics Simulation; Nanoparticles; Neoplasms; Quinazolines; Rats; Thiophenes | 2018 |
Efficacy and safety of raltitrexed-based transarterial chemoembolization for colorectal cancer liver metastases.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoembolization, Therapeutic; China; Colorectal Neoplasms; Disease Progression; Ethiodized Oil; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Middle Aged; Oxaliplatin; Prospective Studies; Quinazolines; Survival; Thiophenes | 2018 |
[Data review and analysis of 22 cases of gastric cancer associated with pregnancy].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Signet Ring Cell; Cesarean Section; China; Female; Fluorouracil; Gastrectomy; Humans; Irinotecan; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Pregnancy; Pregnancy Complications, Neoplastic; Prognosis; Quinazolines; Stomach Neoplasms; Survival Rate; Thiophenes | 2018 |
Transarterial chemoembolization with raltitrexed-based or floxuridine-based chemotherapy for unresectable colorectal cancer liver metastasis.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoembolization, Therapeutic; Colorectal Neoplasms; Female; Floxuridine; Humans; Liver Neoplasms; Male; Middle Aged; Prognosis; Quinazolines; Retrospective Studies; Survival Analysis; Thiophenes; Treatment Outcome | 2019 |
Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines-Pretreated or High-Risk Cardiac Patients With GI Malignancies: Large Single-Center Experience.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Prognosis; Quinazolines; Retrospective Studies; Safety; Survival Rate; Thiophenes | 2019 |
Multivalent nanoparticles for personalized theranostics based on tumor receptor distribution behavior.
Topics: Animals; Cell Line, Tumor; Cell Survival; Contrast Media; Drug Carriers; Drug Delivery Systems; Endocytosis; Folate Receptors, GPI-Anchored; Gene Expression; Humans; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice; Neoplasms; Polyethyleneimine; Quinazolines; Theranostic Nanomedicine; Thiophenes; Xenograft Model Antitumor Assays | 2019 |
Hepatic Artery and Peripheral Vein Pharmacokinetics of Raltitrexed in Swine After the Administration of a Hepatic Arterial Infusion.
Topics: Animals; Female; Hepatic Artery; Male; Quinazolines; Swine; Thiophenes | 2019 |
Enhancing chemoradiation of colorectal cancer through targeted delivery of raltitrexed by hyaluronic acid coated nanoparticles.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Damage; Drug Carriers; Histones; Humans; Hyaluronic Acid; Kaplan-Meier Estimate; Liver; Mice; Mice, Inbred BALB C; Nanoparticles; Quinazolines; Radiation, Ionizing; Thiophenes; Transplantation, Heterologous | 2019 |
Acceleration of interstitial lung disease induced by raltitrexed.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Progression; Humans; Lung Diseases, Interstitial; Male; Quinazolines; Thiophenes | 2020 |
Clinical efficacy of irinotecan plus raltitrexed chemotherapy in refractory esophageal squamous cell cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Follow-Up Studies; Humans; Irinotecan; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Quinazolines; Retrospective Studies; Salvage Therapy; Survival Rate; Thiophenes | 2020 |
Hyperthermic intraperitoneal chemotherapy with recombinant mutant human TNF-α and raltitrexed in mice with colorectal-peritoneal carcinomatosis.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Colorectal Neoplasms; HCT116 Cells; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Peritoneal Neoplasms; Quinazolines; Recombinant Proteins; Thiophenes; Tumor Necrosis Factor-alpha | 2020 |
A Case-Control Study on the Correlation Between Thymidylate Synthase Gene Polymorphisms and Raltitrexed Treatment Combined with Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma Treatment.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Pharmacological; Carcinoma, Hepatocellular; Case-Control Studies; Chemoembolization, Therapeutic; Combined Modality Therapy; Female; Humans; Liver Neoplasms; Male; Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Quinazolines; Survival Rate; Thiophenes; Thymidylate Synthase; Treatment Outcome | 2020 |
Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN-amplified neuroblastoma cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA Damage; Dose-Response Relationship, Drug; Gene Amplification; Humans; Metabolic Networks and Pathways; N-Myc Proto-Oncogene Protein; Neuroblastoma; Quinazolines; Thiophenes; Thymidylate Synthase | 2020 |
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Proliferation; Drug Resistance, Neoplasm; Drug Therapy, Combination; Enzyme Inhibitors; Female; Fluorouracil; Humans; Liposomes; Ovarian Neoplasms; Peptide Fragments; Polyethylene Glycols; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2020 |
Tolerability of pemetrexed and oxaliplatin in the treatment of stage III colon cancer during raltitrexed shortage.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Canada; Colonic Neoplasms; Female; Humans; Kidney Diseases; Middle Aged; Oxaliplatin; Pemetrexed; Quinazolines; Thiophenes; Tomography, X-Ray Computed; Treatment Outcome | 2021 |
Real-world Safety and Efficacy of Raltitrexed in Patients With Metastatic Colorectal Cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Canada; Colorectal Neoplasms; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Quinazolines; Thiophenes; Treatment Outcome | 2021 |
A comparison between raltitrexed plus cisplatin and docetaxel plus cisplatin in concurrent chemoradiation for non-surgical esophageal squamous cell carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplatin; Docetaxel; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Humans; Male; Middle Aged; Quinazolines; Radiotherapy, Intensity-Modulated; Regression Analysis; Retrospective Studies; Survival Rate; Thiophenes; Treatment Outcome | 2021 |
Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil.
Topics: Antineoplastic Agents; Cell Line, Tumor; Colorectal Neoplasms; DNA Damage; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Quinazolines; Thiophenes; Uracil-DNA Glycosidase | 2021 |
Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism.
Topics: Aging; Animals; Apoptosis; Brain; Cognitive Dysfunction; Dietary Supplements; Folic Acid; Male; Memory; Mice; Morris Water Maze Test; Neurons; Quinazolines; Telomere Shortening; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Uracil | 2021 |
Thymidylate synthase is essential for efficient HIV-1 replication in macrophages.
Topics: Cells, Cultured; Enzyme Inhibitors; HIV-1; Humans; Macrophages; Quinazolines; RNA Interference; RNA, Small Interfering; SAM Domain and HD Domain-Containing Protein 1; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Virus Replication | 2021 |
First-line chemotherapy with raltitrexed in metastatic colorectal cancer: an Association des Gastro-entérologues Oncologues (AGEO) multicentre study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colonic Neoplasms; Colorectal Neoplasms; Humans; Quinazolines; Rectal Neoplasms; Retrospective Studies; Thiophenes | 2022 |
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Topics: Chemoembolization, Therapeutic; Humans; Iopamidol; Microspheres; Quinazolines; Thiophenes | 2023 |
A γ-glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells.
Topics: Cell Line, Tumor; Cell Survival; CRISPR-Cas Systems; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Gene Editing; Glycosylation; HeLa Cells; Humans; Lymphocytes; Lysosomes; Methotrexate; Polyglutamic Acid; Protein Sorting Signals; Quinazolines; Thiophenes | 2022 |
Preliminary outcomes of raltitrexed eluting bead-transarterial chemoembolization using Callispheres® beads for gastrointestinal adenocarcinoma liver metastasis.
Topics: Aged; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Female; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Male; Microspheres; Middle Aged; Quinazolines; Retrospective Studies; Thiophenes; Treatment Outcome | 2022 |
Raltitrexed regulates proliferation and apoptosis of HGC-27 cells by upregulating RSK4.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Quinazolines; Stomach Neoplasms; Thiophenes | 2022 |
Clinical Outcomes of Drug-Eluting Bead Transarterial Chemoembolization Loaded with Raltitrexed for the Treatment of Unresectable or Recurrent Hepatocellular Carcinoma.
Topics: Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Doxorubicin; Humans; Liver Neoplasms; Quinazolines; Retrospective Studies; Thiophenes; Treatment Outcome | 2022 |