quinazolines has been researched along with r 59949 in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 14 (56.00) | 18.2507 |
| 2000's | 10 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodríguez-Liñares, B; Walker, T; Watson, S | 1 |
| de Chaffoy de Courcelles, D | 1 |
| de Chaffoy de Courcelles, D; De Clerck, F; Kennis, L; Roevens, P; Somers, Y; Van Belle, H | 1 |
| Bollen, M; De Smedt, H; Himpens, B | 1 |
| Hoyer, J; Papp, A | 1 |
| Barrington, M; Kotsonis, P; Majewski, H; Murphy, TV | 1 |
| Conway, AM; Pyne, NJ; Pyne, S; Tolan, D | 1 |
| Deng, XF; Mulay, S; Varma, DR | 1 |
| Bursell, SE; Clermont, AC; Ishii, H; King, GL; Mori, F; Takagi, C; Takagi, H | 1 |
| Díaz, E; Flores, I; Jones, DR; Martinez, C; Mérida, I | 1 |
| Hurttia, H; Leino, L; Saarinen, K | 1 |
| Abd-Elfattah, AS; Sholley, MM; Taher, MM | 1 |
| Ciprés, A; Díaz-Flores, E; Flores, I; Jones, DR; Mérida, I; Sanjuan, MA | 1 |
| Curnutte, JT; Erickson, RW; Heyworth, PG; Langel-Peveri, P; Traynor-Kaplan, AE | 1 |
| Kurz, T; Richardt, G; Schneider, I; Tölg, R | 1 |
| Jiang, Y; Kanoh, H; Sakane, F; Walsh, JP | 1 |
| Foubert, TR; Jesaitis, AJ; Marodi, L; McPhail, LC; Palicz, A | 1 |
| Alfranca, A; Aragonés, J; Jones, DR; Landázuri, MO; Martin, S; Mérida, I; San Juan, MA; Vara, A; Vidal, F | 1 |
| Du, X; Jiang, Y; Lu, X; Qian, W; Walsh, JP | 1 |
| Crompton, T; Martinez-A, C; Merida, I; Outram, SV; Varas, A | 1 |
| Eppinger, E; Meinhardt, G; Schmidmaier, R | 1 |
| D'Isanto, M; Finamore, E; Galdiero, M; Peluso, L; Vitiello, M | 1 |
| Houkin, K; Imai, S; Kai, M; Kanoh, H; Sakane, F; Tsushima, S; Yamada, K | 1 |
| Keshavan, V; Shanthi, M; Tyagi, MG; Vikram, GS | 1 |
| Acosta-Iborra, B; Aragonés, J; Castellanos, MC; Feijoo-Cuaresma, M; Landazuri, MO; Martín-Puig, S; Olmos, G; Temes, E | 1 |
1 review(s) available for quinazolines and r 59949
| Article | Year |
|---|---|
The use of diacylglycerol kinase inhibitors for elucidating the roles of protein kinase C.
Topics: Animals; Blood Platelets; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Humans; Neutrophils; Phosphotransferases; Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Rabbits; Receptors, Cell Surface; Second Messenger Systems; Thiazoles | 1990 |
24 other study(ies) available for quinazolines and r 59949
| Article | Year |
|---|---|
The diacylglycerol kinase inhibitor, R59949, potentiates secretion but not increased phosphorylation of a 47 kDalton protein in human platelets.
Topics: Blood Platelets; Diacylglycerol Kinase; Dose-Response Relationship, Drug; Humans; Phosphatidic Acids; Phosphorylation; Phosphotransferases; Piperidines; Protein Kinase C; Quinazolines; Quinazolinones; Serotonin; Thrombin | 1991 |
The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. A biochemical and functional analysis using the novel diacylglycerol kinase inhibitor, R 59 949.
Topics: Blood Platelets; Calcium; Cell Membrane; Collagen; Cyclic AMP; Diacylglycerol Kinase; Diglycerides; Glycerides; Humans; Phosphates; Phosphatidylinositols; Phospholipids; Phosphoproteins; Phosphorylation; Phosphotransferases; Piperidines; Platelet Aggregation; Protein Kinase C; Quinazolines; Quinazolinones; Second Messenger Systems; Thromboxane B2; Vasopressins | 1989 |
Modulation of nucleocytosolic [Ca2+] gradient in smooth muscle by protein phosphorylation.
Topics: Adenosine Triphosphate; Animals; Benzoquinones; Calcium; Cell Line; Cell Nucleus; Colforsin; Cricetinae; Cytosol; Diacylglycerol Kinase; Epidermal Growth Factor; Ethers, Cyclic; Homeostasis; Kinetics; Lactams, Macrocyclic; Leiomyosarcoma; Marine Toxins; Mesocricetus; Models, Biological; Muscle, Smooth; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Kinase C; Protein Kinases; Protein Tyrosine Phosphatases; Quinazolines; Quinazolinones; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
PKC-dependent reduction of the acetylcholine-evoked inward Na current in Aplysia D-neurons: effect of injected PKC and PKC activators.
Topics: Acetylcholine; Animals; Aplysia; Dimethyl Sulfoxide; Enzyme Activation; Evoked Potentials; Ganglia, Invertebrate; In Vitro Techniques; Membrane Potentials; Naphthalenes; Neurons; Phorbol Esters; Piperidines; Protein Kinase C; Quinazolines; Quinazolinones; Sodium Channels; Sulfonamides | 1996 |
Noradrenaline release and the effect of endogenous activation of the phospholipase C/protein kinase C signalling pathway in rat atria.
Topics: Androstadienes; Animals; Atrial Function; Diacylglycerol Kinase; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Estrenes; Heart Atria; Male; Norepinephrine; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Kinase C; Pyrrolidinones; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Type C Phospholipases; Wortmannin | 1997 |
Sphingosine prevents diacylglycerol signaling to mitogen-activated protein kinase in airway smooth muscle.
Topics: 1-Butanol; Animals; Bradykinin; Butanols; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Kinetics; Muscle, Smooth; Palmitic Acid; Phosphatidate Phosphatase; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Platelet-Derived Growth Factor; Protein Kinase C; Quinazolines; Quinazolinones; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Trachea | 1997 |
Role of Ca(2+)-independent PKC in alpha 1-adrenoceptor-mediated inotropic responses of neonatal rat hearts.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Calcium; Carbazoles; Diacylglycerol Kinase; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Heart Ventricles; In Vitro Techniques; Indoles; Inositol Phosphates; Isoenzymes; Isoproterenol; Maleimides; Methoxamine; Myocardial Contraction; Myocardium; Phenylephrine; Phorbol 12,13-Dibutyrate; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Kinase C; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 1997 |
Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats.
Topics: Animals; Blood Flow Velocity; Diabetes Mellitus, Experimental; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; Fluorescein Angiography; Hyperglycemia; Indoles; Isoenzymes; Male; Maleimides; Piperidines; Protein Kinase C; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Retina; Retinal Vessels | 1997 |
Interleukin-2 stimulates a late increase in phosphatidic acid production in the absence of phospholipase D activation.
Topics: 3T3 Cells; Animals; Cell Line; Diacylglycerol Kinase; Enzyme Activation; Enzyme Inhibitors; Humans; Interleukin-2; Isoenzymes; Mice; Phosphatidic Acids; Phospholipase D; Piperidines; Quinazolines; Quinazolinones; Recombinant Proteins; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1998 |
Increased adhesion of peripheral blood neutrophils from patients with localized juvenile periodontitis.
Topics: Adolescent; Adult; Aggressive Periodontitis; Case-Control Studies; Cell Adhesion; Child; Diacylglycerol Kinase; Enzyme Inhibitors; Female; Humans; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperidines; Quinazolines; Quinazolinones; Reactive Oxygen Species; Respiratory Burst; Zymosan | 1998 |
Sphingosine induces phospholipase D and mitogen activated protein kinase in vascular smooth muscle cells.
Topics: Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Diacylglycerol Kinase; Enzyme Activation; Ethanol; Glycerophospholipids; Muscle, Smooth, Vascular; Phosphatidic Acids; Phospholipase D; Piperidines; Protein Kinase C; Quinazolines; Quinazolinones; Rats; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Type C Phospholipases | 1998 |
Diacylglycerol kinase inhibition prevents IL-2-induced G1 to S transition through a phosphatidylinositol-3 kinase-independent mechanism.
Topics: Animals; Cell Cycle; Cell Cycle Proteins; Cell Line; Culture Media, Serum-Free; Cyclin D3; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Diacylglycerol Kinase; Enzyme Activation; Enzyme Inhibitors; G1 Phase; Gene Expression Regulation; Interleukin-2; Interleukin-4; Mice; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; Piperidines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogenes; Quinazolines; Quinazolinones; Retinoblastoma Protein; S Phase; T-Lymphocytes, Cytotoxic; Tumor Suppressor Proteins | 1999 |
Activation of human neutrophil NADPH oxidase by phosphatidic acid or diacylglycerol in a cell-free system. Activity of diacylglycerol is dependent on its conversion to phosphatidic acid.
Topics: Cell-Free System; Diacylglycerol Kinase; Diglycerides; Drug Synergism; Enzyme Activation; Humans; Kinetics; NADPH Oxidases; Neutrophils; Phosphatidic Acids; Piperidines; Quinazolines; Quinazolinones; Second Messenger Systems; Superoxides | 1999 |
Alpha 1-adrenergic receptor-mediated increase in the mass of phosphatidic acid and 1,2-diacylglycerol in ischemic rat heart.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Chromatography, Thin Layer; Desipramine; Diacylglycerol Kinase; Diglycerides; Estrenes; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Norepinephrine; Perfusion; Phosphatidic Acids; Piperidines; Prazosin; Propranolol; Pyrrolidinones; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Time Factors; Type C Phospholipases | 1999 |
Selectivity of the diacylglycerol kinase inhibitor 3-[2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl]-2, 3-dihydro-2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Calcium; Catalytic Domain; COS Cells; Diacylglycerol Kinase; Enzyme Inhibitors; Isoenzymes; Mice; Piperidines; Quinazolines; Quinazolinones; Saccharomyces cerevisiae; Substrate Specificity | 2000 |
Phosphatidic acid and diacylglycerol directly activate NADPH oxidase by interacting with enzyme components.
Topics: Cell-Free System; Diglycerides; Enzyme Activation; Humans; In Vitro Techniques; NADPH Oxidases; Neutrophils; Phosphatidic Acids; Phosphoproteins; Piperidines; Quinazolines; Quinazolinones; Recombinant Proteins | 2001 |
Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension.
Topics: Cell Nucleus; Diacylglycerol Kinase; Diglycerides; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Luciferases; Nuclear Proteins; Oxygen; Phosphatidic Acids; Phospholipids; Piperidines; Plasmids; Pyrimidinones; Quinazolines; Quinazolinones; Recombinant Proteins; Signal Transduction; Thiazoles; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection | 2001 |
Fatty acids inhibit growth-factor-induced diacylglycerol kinase alpha activation in vascular smooth-muscle cells.
Topics: Animals; Carotid Arteries; Cell Membrane; Cells, Cultured; Cytosol; Diacylglycerol Kinase; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Escherichia coli; Fatty Acids, Nonesterified; Isoenzymes; Kinetics; Muscle, Smooth, Vascular; Oleic Acid; Palmitic Acid; Piperidines; Platelet-Derived Growth Factor; Quinazolines; Quinazolinones; Recombinant Proteins; Swine; Thrombin | 2001 |
Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte development.
Topics: Animals; bcl-X Protein; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Cell Survival; Cells, Cultured; Diacylglycerol Kinase; Enzyme Inhibitors; Gene Expression Regulation; Genes, bcl-2; Isoenzymes; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mice, Inbred BALB C; Mice, Transgenic; Piperidines; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Quinazolinones; Receptors, Antigen, T-Cell, alpha-beta; Signal Transduction; T-Lymphocytes | 2002 |
Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; CD11c Antigen; CD4 Antigens; Cell Cycle; Cell Differentiation; Diacylglycerol Kinase; Enzyme Activators; Enzyme Inhibitors; Farnesol; Flow Cytometry; Genes, fos; Genes, jun; Humans; Immunoblotting; Isoenzymes; Leukemia, Myeloid; Naphthalenes; Oncogene Protein p21(ras); Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Sulfonamides; Thiazoles; Triazoles; Tumor Cells, Cultured | 2002 |
Monocytic activation of protein tyrosine kinase, protein kinase A and protein kinase C induced by porins isolated from Salmonella enterica serovar Typhimurium.
Topics: Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Inhibitors; Humans; Isoquinolines; L-Lactate Dehydrogenase; Lipopolysaccharides; Monocytes; Naphthalenes; Piperidines; Porins; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Quinazolinones; Salmonella typhimurium; Signal Transduction; Sulfonamides; Tyrphostins; U937 Cells | 2003 |
Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation.
Topics: Animals; Blotting, Western; cdc42 GTP-Binding Protein; Cell Movement; COS Cells; Diacylglycerol Kinase; Fibronectins; Genes, Dominant; Glutathione Transferase; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mice; Microscopy, Fluorescence; Mutation; NIH 3T3 Cells; Piperidines; Plasmids; Platelet-Derived Growth Factor; Precipitin Tests; Protein Binding; Pseudopodia; Quinazolines; Quinazolinones; rac1 GTP-Binding Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transfection | 2004 |
Phospholipid mediators and MgATPase modulation causes changes in the cardiovascular effects of vasopressin in lithium carbonate-induced polyuric rats.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Ca(2+) Mg(2+)-ATPase; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Heart Rate; Injections, Intraperitoneal; Injections, Intravenous; Lithium Carbonate; Lypressin; Mice; Motor Activity; Neomycin; Phospholipids; Piperidines; Polyuria; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Sphingosine | 2004 |
Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase.
Topics: Cell Line; Diacylglycerol Kinase; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoprecipitation; Piperidines; Procollagen-Proline Dioxygenase; Quinazolines; Quinazolinones; RNA, Messenger; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein | 2005 |