Compounds > quinazolines
Page last updated: 2024-08-21

quinazolines and quinoxalines

quinazolines has been researched along with quinoxalines in 59 studies

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-19904 (6.78)18.7374
1990's13 (22.03)18.2507
2000's21 (35.59)29.6817
2010's16 (27.12)24.3611
2020's5 (8.47)2.80

Authors

AuthorsStudies
Calligaro, DO; Lodge, D; McQuaid, LA; Mitch, CH; O'Malley, PJ; Ornstein, PL; Schoepp, DD; Smith, EC; South, KK; True, RA1
Arif, AJ; Bhaduri, AP; Dhar, MM; Gupta, CM; Khan, AW; Singh, C2
Dunlap, RB; Ellis, PD; Lyon, JA1
Henry, DW; Horner, JK1
Giardinà, D; Gulini, U; Massi, M; Melchiorre, C; Piloni, MG; Pompei, P; Rafaiani, G1
Carter, DB; Hamilton, BJ; Im, HK; Im, WB; Jacobsen, EJ; Pregenzer, JF; TenBrink, RE; VonVoigtlander, PF1
Crucianelli, M; Giardinà, D; Melchiorre, C; Taddei, C; Testa, R1
Crucianelli, M; Giardinà, D; Leonardi, A; Melchiorre, C; Poggesi, E; Romanelli, R1
Barghash, AM; el-Ashmawy, MB; el-Bendary, ER; el-Kerdawy, MM; Shehata, IA1
Loriga, M; Paglietti, G; Vitale, G1
Corona, P; Loriga, M; Paglietti, G; Vitale, G1
Bleuel, Z; Clifford, MM; Ellis, GJ; Humbel, U; Klingelschmidt, A; Messer, J; Mutel, V; Richards, JG; Trube, G1
Cui, M; Czarnik, AW; Heldsinger, A; Lemrow, SM; Loo, JA; Mei, HY; Sannes-Lowery, KA; Sharmeen, L1
Saxena, PR; Stam, WB; Van der Graaf, PH1
Budriesi, R; Chiarini, A; Leonardi, A; Melchiorre, C; Minarini, A1
Endo, T; Hirafuji, M; Kato, K; Minami, M; Ogawa, T; Satoh, Y; Suzuguchi, T1
Daaka, Y; Lefkowitz, RJ; Luttrell, LM; Maudsley, S; Pierce, KL1
De Groat, WC; Yoshiyama, M1
Boon, K; Fooks, HM; Hourani, SM; Prentice, DJ1
Endo, T; Hamaue, N; Hirafuji, M; Kato, K; Minami, M; Ogawa, T; Parvez, H1
Cussac, D; Denis, C; Paris, H; Schaak, S1
Bouregeois, NM; Corbett, TH; Crantz, B; Hazeldine, ST; Horwitz, JP; Kushner, J; Palomino, E; Polin, L; White, K1
Carter, RW; Kanagy, NL1
Angeli, P; Giardinà, D; Gulini, U; Leonardi, A; Marucci, G; Melchiorre, C; Poggesi, E; Polimanti, O; Sagratini, G1
Cerri, PS; de Arruda Camargo, GM; de Arruda Camargo, LA; Saad, WA1
Ikeda, M1
Avellar, MC; Hamamura, M; Mendes, FR; Porto, CS; Queiróz, DB1
Carvalho, LC; de Moura, RS; Madeira, SV; Miranda, DZ; Pinto, AC; Rangel, BM; Resende, AC; Rubenich, LM; Sicca, RF; Souza, MA; Tano, T1
Antolini, L; Giardinà, D; Grelli, M; Gulini, U; Melchiorre, C; Sagratini, G1
Hattori, K; Ishida, J; Iwashita, A; Kamijo, K; Kido, Y; Kinoshita, T; Matsuoka, N; Miyake, H; Murano, K; Mutoh, S; Ohkubo, M; Warizaya, M; Yamamoto, H1
Angeli, P; Buccioni, M; Giardinà, D; Gulini, U; Marucci, G; Melchiorre, C; Sagratini, G; Testa, R1
Hattori, K; Ishida, J; Iwashita, A; Kamijo, K; Kido, Y; Kinoshita, T; Matsuoka, N; Mihara, K; Miyake, H; Murano, K; Ohkubo, M; Warizaya, M; Yamamoto, H1
Devaiah, V; Kamal, A; Rao, MV; Reddy, KL; Shankaraiah, N1
Banville, J; Beaulieu, F; Belema, M; Burke, JR; Gregor, KR; MacMaster, JF; Martel, A; McIntyre, KW; Ouellet, C; Pattoli, MA; Qiu, Y; Ruediger, EH; Vyas, D; Yang, X; Zusi, FC1
Angeli, P; Buccioni, M; Giardinà, D; Gulini, U; Leonardi, A; Marucci, G; Melchiorre, C; Poggesi, E; Sagratini, G1
Bexis, S; Docherty, JR1
Imanishi, A; Latifpour, J; Ueda, S; Yamamoto, Y; Yono, M; Yoshida, M1
Catarzi, D; Colotta, V; Filacchioni, G; Lenzi, O; Lingenhöhl, K; Ofner, S; Poli, D; Varano, F1
Nevalainen, T; Saari, R; Törmä, JC1
Baselga, J; Chandarlapaty, S; Grbovic-Huezo, O; Majumder, PK; Rodrik-Outmezguine, V; Rosen, N; Sawai, A; Scaltriti, M; Serra, V1
Bhardwaj, V; Chauhan, A; Noolvi, MN; Patel, HM1
Boblak, KN; Klumpp, DA; Raja, EK; Sheets, MR; Zhang, Y1
Kaul, M; LaVoie, EJ; Parhi, AK; Pilch, DS; Pradhan, P; Saionz, KW; Trivedi, K; Zhang, Y1
Gathergood, N; Ghavre, M; Kuneš, J; Mikušek, J; Pour, M; Pourová, J; Špulák, M; Vacek, J; Vopršálová, M1
Cohen, RB; Engelman, JA; Felip, E; Jänne, PA; Laird, AD; Macé, S; Martinez, P; Rockich, K; Ruiz-Soto, R; Shapiro, GI; Xu, J1
Bertrand, M; Correa, RJ; DiMattia, GE; Fazio, EN; McGee, J; Peart, TM; Préfontaine, M; Shepherd, TG; Sugimoto, A; Valdes, YR1
Geng, Z; Han, X; Hu, L; Li, Z; Qin, X; Wang, Z; Xiao, X; Zeng, C1
Corrêa, MF; dos Santos Fernandes, JP1
Aono, Y; Cools, AR; Koshikawa, N; Saigusa, T; Shimizu, N; Shirakawa, T; Taguchi, H; Takada, K; Takiguchi, H; Uchida, T1
Bahleda, R; Burris, H; Jiang, J; Lager, J; Liu, L; LoRusso, P; Macé, S; Martini, JF; Soria, JC1
Kang, J; Kim, DY; Kim, YK; Lee, SE; Yoon, SS1
Cousin, S; Italiano, A; Leroy, L1
Abdelkarim, H; Albee, LJ; Gao, X; Gaponenko, V; Majetschak, M; Volkman, BF1
Badri, R; Khaksar, S; Malamiri, F; Tahanpesar, E1
Alsufyani, HA; Docherty, JR; McCormick, PA1
Damodar, K; Gim, JG; Jeon, SH; Lee, JT; Lee, Y; Nam, KY; Park, JP; Park, LS1
Javle, M; King, G1
Chalmers, DK; Cridge, RR; de Zhang, LA; Deluigi, M; Eberle, SA; Egloff, P; Klenk, C; Klipp, A; Merklinger, L; Mittl, PRE; Morstein, L; Plückthun, A; Schuster, M; Scott, DJ; Vacca, S; Vaid, TM; Zerbe, O1

Reviews

4 review(s) available for quinazolines and quinoxalines

ArticleYear
[How have we found any new reactions in the field of the heterocyclic chemistry?].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2004, Volume: 124, Issue:4

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Cyclization; Heterocyclic Compounds; Hydroxylamine; Hydroxylamines; Indoles; Quinazolines; Quinolines; Quinoxalines

2004
Recent advances in the solid-phase combinatorial synthetic strategies for the quinoxaline, quinazoline and benzimidazole based privileged structures.
    Mini reviews in medicinal chemistry, 2006, Volume: 6, Issue:1

    Topics: Benzimidazoles; Benzothiadiazines; Combinatorial Chemistry Techniques; Heterocyclic Compounds, 2-Ring; Indazoles; Molecular Structure; Phthalazines; Pyrans; Quinazolines; Quinoxalines

2006
Histamine H4 receptor ligands: future applications and state of art.
    Chemical biology & drug design, 2015, Volume: 85, Issue:4

    Topics: Animals; Drug Discovery; Humans; Imidazoles; Indoles; Inflammation; Ligands; Models, Molecular; Pyrimidines; Quinazolines; Quinoxalines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship

2015
FGFR Inhibitors: Clinical Activity and Development in the Treatment of Cholangiocarcinoma.
    Current oncology reports, 2021, 07-16, Volume: 23, Issue:9

    Topics: Aniline Compounds; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Clinical Trials as Topic; Humans; Morpholines; Mutation; Phenylurea Compounds; Precision Medicine; Pyrazoles; Pyrimidines; Pyrroles; Quinazolines; Quinoxalines; Receptors, Fibroblast Growth Factor; Signal Transduction

2021

Trials

2 trial(s) available for quinazolines and quinoxalines

ArticleYear
Phase I safety and pharmacokinetic study of the PI3K/mTOR inhibitor SAR245409 (XL765) in combination with erlotinib in patients with advanced solid tumors.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014, Volume: 9, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; ErbB Receptors; Erlotinib Hydrochloride; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Prognosis; Protein Kinase Inhibitors; Quinazolines; Quinoxalines; Safety; Sulfonamides; Survival Rate; Tissue Distribution; TOR Serine-Threonine Kinases

2014
Phase I dose-escalation study of pilaralisib (SAR245408, XL147), a pan-class I PI3K inhibitor, in combination with erlotinib in patients with solid tumors.
    The oncologist, 2015, Volume: 20, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Male; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Quinoxalines; Sulfonamides; Treatment Outcome

2015

Other Studies

53 other study(ies) available for quinazolines and quinoxalines

ArticleYear
Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones.
    Journal of medicinal chemistry, 1992, Sep-04, Volume: 35, Issue:18

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glycine; Ibotenic Acid; Male; Quinazolines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship

1992
Actinomycetes studies. II. Cell-free synthesis of echinomycin and an echinomycin analogue.
    Indian journal of biochemistry, 1970, Volume: 7, Issue:3

    Topics: Acetates; Adenosine Triphosphate; Alanine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carboxylic Acids; Cell-Free System; Dialysis; Magnesium; Mercaptoethanol; Microbial Sensitivity Tests; Quinazolines; Quinoxalines; Rats; Staphylococcus; Stimulation, Chemical; Streptomyces

1970
Assignment of the carbon-13 nuclear magnetic resonance spectrum of folic acid.
    Biochemistry, 1973, Jun-19, Volume: 12, Issue:13

    Topics: Aminobenzoates; Benzamides; Carbon Isotopes; Chemical Phenomena; Chemistry; Deuterium; Folic Acid; Glutamates; Magnetic Resonance Spectroscopy; Protons; Pteridines; Purines; Quinazolines; Quinoxalines; Ribonucleosides

1973
Studies on the cell-free synthesis of echinomycin and an echinomycin analogue.
    Pure and applied chemistry. Chimie pure et appliquee, 1971, Volume: 28, Issue:4

    Topics: Adenosine Triphosphate; Anti-Bacterial Agents; Cell-Free System; Culture Media; Magnesium; Mercaptoethanol; Quinazolines; Quinoxalines; Streptomyces; Structure-Activity Relationship

1971
Analogs of 3-amino-7-chloro-1,2,4-benzotriazine 1-oxide as antimalarial agents.
    Journal of medicinal chemistry, 1968, Volume: 11, Issue:5

    Topics: Animals; Antimalarials; Chickens; Heterocyclic Compounds; Mice; Oxides; Quinazolines; Quinolines; Quinoxalines

1968
Structure-activity relationships in prazosin-related compounds. 2. Role of the piperazine ring on alpha-blocking activity.
    Journal of medicinal chemistry, 1993, Mar-19, Volume: 36, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Hemodynamics; Male; Piperazines; Prazosin; Quinazolines; Quinoxalines; Rats; Rats, Inbred SHR; Stereoisomerism; Structure-Activity Relationship

1993
Differential affinity of dihydroimidazoquinoxalines and diimidazoquinazolines to the alpha 1 beta 2 gamma 2 and alpha 6 beta 2 gamma 2 subtypes of cloned GABAA receptors.
    British journal of pharmacology, 1993, Volume: 110, Issue:2

    Topics: Cells, Cultured; Electrophysiology; Female; Humans; Imidazoles; Kidney; Ligands; Molecular Conformation; Pregnancy; Quinazolines; Quinoxalines; Receptors, GABA-A; Structure-Activity Relationship

1993
Receptor binding profile of cyclazosin, a new alpha 1B-adrenoceptor antagonist.
    European journal of pharmacology, 1995, Dec-04, Volume: 287, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Brain; Male; Prazosin; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1

1995
Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.
    Journal of medicinal chemistry, 1996, Nov-08, Volume: 39, Issue:23

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Cattle; Cerebral Cortex; CHO Cells; COS Cells; Cricetinae; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Stereoisomerism

1996
Synthesis of some new quinazolines and quinoxalines of potential antiinflammatory activity.
    Bollettino chimico farmaceutico, 1996, Volume: 135, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Quinazolines; Quinoxalines; Rats

1996
Quinoxaline chemistry. Part 9. Quinoxaline analogues of trimetrexate (TMQ) and 10-propargyl-5,8-dideazafolic acid (CB 3717) and its precursors. Synthesis and evaluation of in vitro anticancer activity.
    Farmaco (Societa chimica italiana : 1989), 1998, Volume: 53, Issue:2

    Topics: Antineoplastic Agents; Folic Acid; Humans; Quinazolines; Quinoxalines; Structure-Activity Relationship; Trimetrexate; Tumor Cells, Cultured

1998
Quinoxaline chemistry. Part 10. Quinoxaline 10-oxa-analogues of trimetrexate (TMQ) and of 5,8-dideazafolic acid. Synthesis and evaluation of in vitro anticancer activity.
    Farmaco (Societa chimica italiana : 1989), 1998, Volume: 53, Issue:2

    Topics: Antineoplastic Agents; Humans; Quinazolines; Quinoxalines; Structure-Activity Relationship; Trimetrexate; Tumor Cells, Cultured

1998
Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain.
    Journal of neurochemistry, 1998, Volume: 71, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Chemistry; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Imidazoles; In Situ Hybridization; Kainic Acid; Kinetics; Male; N-Methylaspartate; Quinazolines; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; RNA, Messenger; Tritium

1998
Inhibitors of protein-RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules.
    Biochemistry, 1998, Oct-06, Volume: 37, Issue:40

    Topics: Allosteric Regulation; Aminoglycosides; Anti-Bacterial Agents; Anti-HIV Agents; Binding, Competitive; Down-Regulation; Drug Design; Gene Products, tat; HIV Long Terminal Repeat; HIV-1; Humans; Quinazolines; Quinoxalines; RNA-Binding Proteins; RNA, Viral; tat Gene Products, Human Immunodeficiency Virus; Transcriptional Activation; Virus Replication

1998
Functional characterisation of the pharmacological profile of the putative alpha1B-adrenoceptor antagonist, (+)-cyclazosin.
    European journal of pharmacology, 1998, Nov-13, Volume: 361, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Dose-Response Relationship, Drug; In Vitro Techniques; Isometric Contraction; Male; Mesenteric Arteries; Mice; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Spleen; Vasoconstrictor Agents

1998
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.
    Bioorganic & medicinal chemistry letters, 1998, Jun-02, Volume: 8, Issue:11

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Drug Design; Humans; In Vitro Techniques; Male; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Spleen; Structure-Activity Relationship; Vas Deferens

1998
[Signal transduction of serotonin release from enterochromaffin cells in mouse ileal crypts].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Clonidine; Enterochromaffin Cells; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Norepinephrine; Phosphodiesterase Inhibitors; Prazosin; Pyrrolidinones; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Rolipram; Serotonin; Signal Transduction; Yohimbine

1998
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-15, Volume: 97, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clathrin; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; GTP-Binding Proteins; Isoproterenol; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Cell Surface; Transfection; Tyrphostins

2000
Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:5

    Topics: Anesthesia, General; Animals; Brain Stem; Efferent Pathways; Female; Injections, Spinal; Locus Coeruleus; Models, Neurological; Muscle Contraction; Piperazines; Pressure; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Reflex; Thymine; Urethane; Urinary Bladder

2001
Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues.
    British journal of pharmacology, 2001, Volume: 133, Issue:6

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Male; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Purinones; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents

2001
Noradrenaline stimulates 5-hydroxytryptamine release from mouse ileal tissues via alpha(2)-adrenoceptors.
    European journal of pharmacology, 2001, Dec-07, Volume: 432, Issue:2-3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Ileum; In Vitro Techniques; Male; Methoxamine; Mice; Mice, Inbred ICR; Norepinephrine; Pertussis Toxin; Phenylephrine; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha-2; Serotonin; Virulence Factors, Bordetella; Yohimbine

2001
alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.
    The Journal of biological chemistry, 2002, May-31, Volume: 277, Issue:22

    Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Arachidonic Acid; Bacterial Proteins; Brimonidine Tartrate; Butadienes; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; MAP Kinase Signaling System; Matrix Metalloproteinases; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; Pertussis Toxin; Phosphorylation; Protein Binding; Proteins; Quinacrine; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Swine; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella

2002
II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469).
    Journal of medicinal chemistry, 2002, Jul-04, Volume: 45, Issue:14

    Topics: Animals; Antineoplastic Agents; Benzoxazoles; Drug Screening Assays, Antitumor; Mice; Neoplasm Transplantation; Propionates; Pyrazines; Pyridines; Quinazolines; Quinolines; Quinoxalines; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazines; Tumor Cells, Cultured

2002
Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Calcium; Enzyme Inhibitors; Flavonoids; Hypertension; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tyrphostins

2002
Searching for cyclazosin analogues as alpha(1B)-adrenoceptor antagonists.
    Farmaco (Societa chimica italiana : 1989), 2003, Volume: 58, Issue:7

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Binding Sites; CHO Cells; Clone Cells; Cricetinae; Guinea Pigs; Humans; Male; Prazosin; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1; Spleen; Vas Deferens

2003
Effects of subtypes of adrenergic and angiotensinergic antagonists on the water and sodium intake induced by adrenaline injected into the paraventricular nucleus.
    Brain research, 2003, Dec-24, Volume: 994, Issue:2

    Topics: Adrenergic alpha-Antagonists; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Diuretics; Dose-Response Relationship, Drug; Drinking; Epinephrine; Feeding Behavior; Furosemide; Losartan; Male; Oligopeptides; Paraventricular Hypothalamic Nucleus; Piperazines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary

2003
Effects of androgen manipulation on alpha1-adrenoceptor subtypes in the rat seminal vesicle.
    Life sciences, 2004, Aug-06, Volume: 75, Issue:12

    Topics: Adrenergic alpha-1 Receptor Antagonists; Analysis of Variance; Androgens; Animals; Autoradiography; Barium Compounds; Chlorides; Clonidine; Cyproterone Acetate; Dioxanes; Gene Expression Regulation; Male; Orchiectomy; Organ Size; Phenylephrine; Piperazines; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; RNA, Messenger; Seminal Vesicles; Testosterone

2004
Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine.
    Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:3

    Topics: Acetylcholine; Administration, Oral; Alcohol Drinking; Animals; Apamin; Atropine; Blood Pressure; Bradykinin; Brazil; Charybdotoxin; Clonidine; Deoxycholic Acid; Drug Therapy, Combination; Endothelium, Vascular; Flavonoids; Glyburide; Guanylate Cyclase; Hypertension; Indomethacin; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroglycerin; Norepinephrine; Oxadiazoles; Perfusion; Phenols; Polyphenols; Potassium Chloride; Pressure; Pyrilamine; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Wine; Yohimbine

2004
Absolute configuration of the alpha (1B)-adrenoceptor antagonist (+)-cyclazosin.
    Farmaco (Societa chimica italiana : 1989), 2004, Volume: 59, Issue:12

    Topics: Adrenergic alpha-1 Receptor Antagonists; Crystallography, X-Ray; Hydrogen Bonding; Molecular Conformation; Quinazolines; Quinoxalines; Stereoisomerism

2004
Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors.
    FEBS letters, 2005, Feb-28, Volume: 579, Issue:6

    Topics: Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Conformation; Quinazolines; Quinoxalines; Structure-Activity Relationship

2005
(+)-Cyclazosin, a selective alpha1B-adrenoceptor antagonist: functional evaluation in rat and rabbit tissues.
    European journal of pharmacology, 2005, Oct-17, Volume: 522, Issue:1-3

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Methoxamine; Molecular Structure; Muscle Contraction; Norepinephrine; Quinazolines; Quinoxalines; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Vas Deferens; Vasoconstriction

2005
Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling.
    Bioorganic & medicinal chemistry, 2006, Mar-01, Volume: 14, Issue:5

    Topics: Binding Sites; Catalytic Domain; Enzyme Inhibitors; Humans; Models, Chemical; Models, Molecular; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Quinoxalines; Structure-Activity Relationship

2006
Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors.
    Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5

    Topics: Benzimidazoles; Cell Line; Heterocyclic Compounds, 4 or More Rings; Humans; I-kappa B Kinase; Inhibitory Concentration 50; Quinazolines; Quinolines; Quinoxalines; Structure-Activity Relationship; Substrate Specificity

2007
Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin.
    Bioorganic & medicinal chemistry, 2007, Mar-15, Volume: 15, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta; Binding, Competitive; Furans; Male; Molecular Structure; Prazosin; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Stereoisomerism; Structure-Activity Relationship; Vas Deferens

2007
Role of alpha1-adrenoceptor subtypes in the effects of methylenedioxy methamphetamine (MDMA) on body temperature in the mouse.
    British journal of pharmacology, 2008, Volume: 153, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Body Temperature; Fever; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Prazosin; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha-1; Thymine

2008
Differential effects of prazosin and naftopidil on pelvic blood flow and nitric oxide synthase levels in spontaneously hypertensive rats.
    Journal of receptor and signal transduction research, 2008, Volume: 28, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Hypertension; Male; Naphthalenes; Nitric Oxide Synthase; Pelvis; Penis; Piperazines; Prazosin; Prostate; Quinazolines; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Regional Blood Flow; Urinary Bladder

2008
Pharmacological characterization of some selected 4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-hydroxyquinazoline-2,4-diones as (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor antagonists.
    Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:7

    Topics: Animals; Anticonvulsants; Mice; Oocytes; Quinazolines; Quinoxalines; Rats; Receptors, AMPA; Seizures

2010
Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists.
    Bioorganic & medicinal chemistry, 2011, Jan-15, Volume: 19, Issue:2

    Topics: Isoquinolines; Microwaves; Morpholines; Quinazolines; Quinolines; Quinoxalines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship

2011
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.
    Cancer cell, 2011, Jan-18, Volume: 19, Issue:1

    Topics: Animals; Benzylamines; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Therapy, Combination; Feedback, Physiological; Female; Forkhead Transcription Factors; Gefitinib; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Nude; Models, Biological; Multiprotein Complexes; Neoplasms; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Quinoxalines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, IGF Type 1; Receptor, Insulin; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation; Xenograft Model Antitumor Assays

2011
Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: search for anticancer agent.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Quinazolines; Quinoxalines; Stereoisomerism; Structure-Activity Relationship

2011
Superacid-promoted additions involving vinyl-substituted pyrimidines, quinoxalines, and quinazolines: mechanisms correlated to charge distributions.
    Journal of the American Chemical Society, 2011, Jun-08, Volume: 133, Issue:22

    Topics: Acids; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidines; Quinazolines; Quinoxalines; Vinyl Compounds

2011
Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines.
    Bioorganic & medicinal chemistry letters, 2013, Sep-01, Volume: 23, Issue:17

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Methicillin Resistance; Microbial Sensitivity Tests; Naphthyridines; Quinazolines; Quinoxalines; Staphylococcal Infections; Staphylococcus aureus; Vancomycin

2013
Novel bronchodilatory quinazolines and quinoxalines: synthesis and biological evaluation.
    European journal of medicinal chemistry, 2014, Mar-03, Volume: 74

    Topics: 3T3 Cells; Animals; Bronchodilator Agents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Inbred BALB C; Quinazolines; Quinoxalines; Rats

2014
Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability.
    Carcinogenesis, 2014, Volume: 35, Issue:9

    Topics: Allosteric Regulation; Antineoplastic Agents; Ascites; Autophagy; Benzylamines; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Inhibitory Concentration 50; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; Quinazolines; Quinoxalines; Spheroids, Cellular

2014
Design, synthesis and biological evaluation of quinoxalin-2(1H)-one derivatives as EGFR tyrosine kinase inhibitors.
    Anti-cancer agents in medicinal chemistry, 2015, Volume: 15, Issue:2

    Topics: Antineoplastic Agents; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Protein Kinase Inhibitors; Quinazolines; Quinoxalines

2015
Simultaneous activation of the α1A-, α1B- and α1D-adrenoceptor subtypes in the nucleus accumbens reduces accumbal dopamine efflux in freely moving rats.
    Behavioural pharmacology, 2015, Volume: 26, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-1 Receptor Agonists; Animals; Dopamine; Dose-Response Relationship, Drug; Male; Methoxamine; Microdialysis; Nucleus Accumbens; Piperazines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1

2015
Blue organic light-emitting diodes based on fluorene-bridged quinazoline and quinoxaline derivatives.
    Luminescence : the journal of biological and chemical luminescence, 2017, Volume: 32, Issue:7

    Topics: Color; Fluorenes; Lasers, Semiconductor; Luminescent Agents; Magnetic Resonance Spectroscopy; Phenanthrolines; Quinazolines; Quinoxalines; Tin Compounds

2017
Genetic determinants of response to fibroblast growth factor receptor inhibitors in solid tumours.
    European journal of cancer (Oxford, England : 1990), 2017, Volume: 81

    Topics: Aged; Aniline Compounds; Benzamides; Biomarkers, Pharmacological; Biomarkers, Tumor; Drug Resistance, Neoplasm; Female; Humans; Male; Middle Aged; Mutation; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Quinazolines; Quinoxalines; Receptors, Fibroblast Growth Factor; Retrospective Studies; Treatment Outcome

2017
Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3.
    PloS one, 2018, Volume: 13, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; beta-Arrestins; Binding Sites; Cells, Cultured; Chemokine CXCL12; Chemotaxis; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Humans; MAP Kinase Signaling System; Myocytes, Smooth Muscle; Nuclear Magnetic Resonance, Biomolecular; Prazosin; Quinazolines; Quinoxalines; Receptors, CXCR; Receptors, CXCR4

2018
Organocatalytic Combinatorial Synthesis of Quinazoline, Quinoxaline and Bis(indolyl)methanes.
    Combinatorial chemistry & high throughput screening, 2020, Volume: 23, Issue:1

    Topics: Catalysis; Combinatorial Chemistry Techniques; Indoles; Methane; Molecular Structure; Phosphoric Acids; Quinazolines; Quinoxalines

2020
Both α
    Pharmacological reports : PR, 2021, Volume: 73, Issue:1

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Male; Muscle Contraction; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Thymine; Yohimbine

2021
Design and Synthesis of π-Extended Resveratrol Analogues and In Vitro Antioxidant and Anti-Inflammatory Activity Evaluation.
    Molecules (Basel, Switzerland), 2021, Jan-26, Volume: 26, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Survival; Gene Expression Regulation; Interleukin-1beta; Interleukin-6; Isoquinolines; Lipopolysaccharides; Mice; Naphthalenes; Quinazolines; Quinolines; Quinoxalines; RAW 264.7 Cells; Resveratrol; Stilbestrols; Structure-Activity Relationship

2021
Crystal structure of the α
    Nature communications, 2022, 01-19, Volume: 13, Issue:1

    Topics: Binding Sites; Crystallography, X-Ray; HEK293 Cells; Humans; Ligands; Lipids; Models, Molecular; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2

2022