Compounds > quinazolines
Page last updated: 2024-08-21

quinazolines and pyrimidinones

quinazolines has been researched along with pyrimidinones in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.76)18.7374
1990's1 (2.38)18.2507
2000's15 (35.71)29.6817
2010's20 (47.62)24.3611
2020's4 (9.52)2.80

Authors

AuthorsStudies
Haginiwa, J; Higuchi, Y; Yamamoto, Y1
de Chaffoy de Courcelles, D1
Fujiwara, M; Noda, K; Saita, M; Soejima, Y; Takamori, M; Tsuji, M; Ueki, S1
Alfranca, A; Aragonés, J; Jones, DR; Landázuri, MO; Martin, S; Mérida, I; San Juan, MA; Vara, A; Vidal, F1
Karasawa, A; Kusaka, H; Mizutani, M; Noji, T; Okamura, Y; Takai, H; Takayama, M1
Avendaño, C; Corzo-Suárez, R; Espada, M; Gago, F; García-Granda, S; Martín-Santamaría, S; Rzepa, HS1
Karasawa, A; Kusaka, H; Nishikawa, S; Noji, T; Sano, J; Sato, H1
Eppinger, E; Meinhardt, G; Schmidmaier, R1
Karasawa, A; Katagiri, C; Kusaka, H; Mizutani, M; Nan-ya, K; Nishikawa, S; Noji, T; Sano, J; Takada, C1
Karasawa, A; Katagiri, C; Kusaka, H; Mizutani, M; Nan-ya, K; Nishikawa, S; Noji, T; Sano, J1
Das, SK; Iqbal, J; Jagadheshan, H; Narasimha Rao Krovvidi, VL1
Karasawa, A; Kusaka, H; Noji, T1
Archer, RG; Hammond, JR1
Baldino, CM; Bi, G; Chapnick, J; Isome, Y; Kaselj, M; Liu, JF; Yohannes, D; Yu, L; Zhang, B1
Natarajan, SR; O'Keefe, SJ; O'Neill, EA; Thompson, JE; Wisnoski, DD1
Hariguchi, N; Hirai, S; Horoiwa, S; Kasahara, R; Kikuchi, H; Matsumoto, M; Oshima, Y; Yamamoto, K1
Bright, J1
Chen, G; Liu, BR; Xie, L1
Hart, JR; Hillmann, P; Hofmann, BT; Sun, M; Vogt, PK1
Black, JL; Burgess, JK; Ge, Q; Moir, LM; Oliver, BG; Shepherd, PR; Trian, T1
Adair, SJ; Bauer, TW; Borgman, CA; Chopivsky, ME; Cowan, CR; Gilmer, TM; Lindberg, JM; Lowrey, BT; Newhook, TE; Parsons, JT; Stelow, EB; Stokes, JB; Walters, DM1
Marzo, I; Naval, J1
Bahra, M; Ehemann, V; Endris, V; Goeppert, B; Kamphues, C; Klauschen, F; Lorenz, K; Muckenhuber, A; Neuhaus, P; Sinn, B; Stenzinger, A; Warth, A; Weichert, W1
Antonakos, B; Cooke, VG; Danial, NN; Flemming, D; Hurov, KE; Jones, MD; Korn, JM; Ledell, J; Lehár, J; Mishina, Y; Schoumacher, M; Sellers, WR; Shao, W; Sonkin, D; Steiger, J; Stump, MD; Yan-Neale, Y1
Battaile, KP; Beletskaya, I; Chirgadze, NY; Gebremeskel, S; Gordon, R; Lam, R; Pai, EF; Qiu, W; Romanov, V; Rottapel, R; Thompson, C; Vodsedalek, J; Voytyuk, O1
Karakashev, SV; Reginato, MJ1
Belani, CP; Joshi, M; Liu, X; Miller, B; Rice, SJ1
Blanco, B; Del Cañizo, MC; Herrero-Sánchez, MC; Rodríguez-Serrano, C; Sánchez-Barba, M1
Banno, E; Boku, N; De Velasco, MA; Fujita, Y; Mizukami, T; Nakajima, TE; Nishio, K; Sakai, K; Sogabe, S; Terashima, M; Togashi, Y; Tomida, S1
Cowan, N; Keiser, J1
Garcia, DA; Gleiser, RM; Nayak, SK; Odhav, B; Sanchez-Borzone, ME; Venugopala, KN1
Dar, AC; Dhawan, NS; Scopton, AP1
Liu, P; Xu, B; Zhang, C1
Beck, S; Frejno, M; Klaeger, S; Koch, H; Kuster, B; Ruprecht, B; Wilhelm, M1
Kaieda, A; Kanzaki, N; Kori, M; Kuno, H; Mototani, H; Naito, T; Nara, H; Oki, H; Santou, T; Sato, K; Terauchi, J; Uchikawa, O; Yamamoto, Y1
Aglar, Ö; Ebrahimi, M; Elofsson, M; Forsberg, Å; Pinto, AF; Saleeb, M; Schüler, H; Sundin, C1
Gupta, P; Mukhopadhyay, CK; Pandey, HS; Seth, P; Singh, P1
Aisa, HA; Cao, JG; Huang, GZ; Liu, FZ; Nie, LF; Wang, SS; Xiamuxi, H1
Cronise, KE; Duval, DL; Gustafson, DL; Hernandez, BG1
Chanana, P; Dood, R; Haemmerle, M; Holland, EC; Lazar, AJ; Lyons, YA; Mangala, LS; Nagaraja, AS; Ravi, V; Siedel, JH; Sood, AK; Wagner, MJ; Wang, WL1
Kang, W; Kwon, JY; Lee, C; Lee, H; Maher, L; Michaud, M; Ning, G; Silva, M; Suh, YS; Zhang, C; Zhu, Q1
Alcívar-León, CD; Cadena-Cruz, JE; Heredia-Moya, J; Zurita, DA1

Reviews

5 review(s) available for quinazolines and pyrimidinones

ArticleYear
The use of diacylglycerol kinase inhibitors for elucidating the roles of protein kinase C.
    Advances in second messenger and phosphoprotein research, 1990, Volume: 24

    Topics: Animals; Blood Platelets; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Humans; Neutrophils; Phosphotransferases; Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Rabbits; Receptors, Cell Surface; Second Messenger Systems; Thiazoles

1990
[Pharmacological study on the effects of the adenosine uptake inhibitor KF24345 on inflammatory diseases].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2003, Volume: 122, Issue:2

    Topics: Acute Disease; Adenosine; Animals; Depression, Chemical; Erythrocytes; Glomerulonephritis; Humans; Inflammation; Leukopenia; Lipopolysaccharides; Mice; Neurotransmitter Uptake Inhibitors; Pancreatitis; Pyrimidinones; Quinazolines; Tumor Necrosis Factor-alpha

2003
[Stem cell-targeted therapy--a new strategy for cancer treatment].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2008, Volume: 30, Issue:11

    Topics: Adenosine; Animals; Antineoplastic Agents; ATP-Binding Cassette Transporters; Biomarkers, Tumor; Cell Differentiation; Diketopiperazines; Heterocyclic Compounds, 4 or More Rings; Humans; Lapatinib; Neoplasms; Neoplastic Stem Cells; Protein Kinase Inhibitors; Pyrimidinones; Quinazolines; Signal Transduction; Triazines; Wnt Proteins

2008
Antimitotic drugs in cancer chemotherapy: promises and pitfalls.
    Biochemical pharmacology, 2013, Sep-15, Volume: 86, Issue:6

    Topics: Antimitotic Agents; Antineoplastic Agents; Benzamides; Clinical Trials as Topic; Cyclin-Dependent Kinases; Humans; Microtubules; Mitosis; Neoplasm Proteins; Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Quinazolines

2013
Diaza-1,3-butadienes as Useful Intermediate in Heterocycles Synthesis.
    Molecules (Basel, Switzerland), 2022, Oct-09, Volume: 27, Issue:19

    Topics: Butadienes; Hydrazones; Imidazolidines; Imidazolines; Imines; Indoles; Isoquinolines; Lactams; Pyrazoles; Pyrimidinones; Quinazolines; Triazoles

2022

Other Studies

37 other study(ies) available for quinazolines and pyrimidinones

ArticleYear
[Reactions concerned in tertiary amine N-oxides. IV. Reactions of 6-methyl-4(3H)-pyrimidinone and 4(3H)-quinazo-linone with pyridine N-oxide (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1975, Volume: 95, Issue:1

    Topics: Chemical Phenomena; Chemistry; Pyridines; Pyrimidinones; Quinazolines

1975
[Effects of quinazoline-2, 4(1H, 3H)-dione compound, H-88 and pyridopyrimidine-2, 4(1H, 3H)-dione compound, HN-37 on pituitary-adrenal axis in rats (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1980, Volume: 76, Issue:8

    Topics: Adrenal Glands; Adrenalectomy; Animals; Ascorbic Acid; Circadian Rhythm; Corticosterone; Dose-Response Relationship, Drug; Edema; Hypophysectomy; Male; Organ Size; Pituitary-Adrenal System; Pyrimidinones; Quinazolines; Rats

1980
Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension.
    The Journal of biological chemistry, 2001, Mar-30, Volume: 276, Issue:13

    Topics: Cell Nucleus; Diacylglycerol Kinase; Diglycerides; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Luciferases; Nuclear Proteins; Oxygen; Phosphatidic Acids; Phospholipids; Piperidines; Plasmids; Pyrimidinones; Quinazolines; Quinazolinones; Recombinant Proteins; Signal Transduction; Thiazoles; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection

2001
KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1

    Topics: Adenosine; Animals; Cricetinae; Erythrocytes; Humans; Leukopenia; Lipopolysaccharides; Mesocricetus; Mice; Neurotransmitter Uptake Inhibitors; Pyrimidinones; Quinazolines; Rabbits; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha

2002
Diastereoselective reactions in glycine templates containing an ent-ardeemin fragment.
    The Journal of organic chemistry, 2002, Apr-05, Volume: 67, Issue:7

    Topics: Alkylation; Chemistry, Organic; Crystallography, X-Ray; Glycine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Pyrazines; Pyrimidinones; Quinazolines; Stereoisomerism

2002
Treatment with an adenosine uptake inhibitor attenuates glomerulonephritis in mice.
    European journal of pharmacology, 2002, Aug-09, Volume: 449, Issue:3

    Topics: Adenosine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Bilirubin; Cyclophosphamide; Erythrocyte Count; Glomerular Mesangium; Glomerulonephritis; Immunosuppressive Agents; Kidney Function Tests; Kidney Tubules; Male; Mice; Neurotransmitter Uptake Inhibitors; Organ Size; Periodic Acid-Schiff Reaction; Prednisolone; Pyrimidinones; Quinazolines; Rabbits; Spleen; Thymus Gland

2002
Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
    Anti-cancer drugs, 2002, Volume: 13, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; CD11c Antigen; CD4 Antigens; Cell Cycle; Cell Differentiation; Diacylglycerol Kinase; Enzyme Activators; Enzyme Inhibitors; Farnesol; Flow Cytometry; Genes, fos; Genes, jun; Humans; Immunoblotting; Isoenzymes; Leukemia, Myeloid; Naphthalenes; Oncogene Protein p21(ras); Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Sulfonamides; Thiazoles; Triazoles; Tumor Cells, Cultured

2002
KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice.
    European journal of pharmacology, 2002, Nov-01, Volume: 454, Issue:1

    Topics: Acute Disease; Adenosine; Amylases; Animals; Choline Deficiency; Diet; Female; L-Lactate Dehydrogenase; Mice; Neurotransmitter Uptake Inhibitors; Organ Size; Pancreas; Pancreatitis; Pyrimidinones; Quinazolines; Time Factors; Tumor Necrosis Factor-alpha

2002
Adenosine uptake inhibition ameliorates cerulein-induced acute pancreatitis in mice.
    Pancreas, 2002, Volume: 25, Issue:4

    Topics: Acute Disease; Adenosine; Amylases; Animals; Biological Transport; Ceruletide; Dipyridamole; Female; Lipase; Mice; Mice, Inbred BALB C; Models, Chemical; Pancreatitis; Piperazines; Pyrimidinones; Quinazolines; Theophylline

2002
Synthetic studies of cis-4-Amino-L-proline derivatives as novel lipid lowering agents.
    Bioorganic & medicinal chemistry letters, 2002, Dec-16, Volume: 12, Issue:24

    Topics: Animals; Hypertriglyceridemia; Hypolipidemic Agents; Mice; Proline; Pyrimidinones; Quinazolines; Structure-Activity Relationship; Triglycerides

2002
Interaction of the novel adenosine uptake inhibitor 3-[1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1H,3H)-quinazolinedione hydrochloride (KF24345) with the es and ei subtypes of equilibrative nucleoside transporters.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:3

    Topics: Adenosine; Allosteric Regulation; Animals; Binding Sites; Biological Transport; Cells, Cultured; Formycins; Humans; Mice; Pyrimidinones; Quinazolines; Rats; Thioinosine; Tritium; Tumor Cells, Cultured

2004
Microwave-assisted concise total syntheses of quinazolinobenzodiazepine alkaloids.
    The Journal of organic chemistry, 2005, Dec-09, Volume: 70, Issue:25

    Topics: Alkaloids; Benzodiazepines; Benzodiazepinones; Methods; Microwaves; Pyrimidinones; Quinazolines

2005
p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.
    Bioorganic & medicinal chemistry letters, 2006, Aug-15, Volume: 16, Issue:16

    Topics: Chemistry, Pharmaceutical; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Models, Chemical; p38 Mitogen-Activated Protein Kinases; Pyridazines; Pyridines; Pyrimidines; Pyrimidinones; Quinazolines; Structure-Activity Relationship

2006
Exploration of a new type of antimalarial compounds based on febrifugine.
    Journal of medicinal chemistry, 2006, Jul-27, Volume: 49, Issue:15

    Topics: Animals; Antimalarials; Cell Line; Malaria; Mice; Parasitic Sensitivity Tests; Piperidines; Plasmodium berghei; Plasmodium falciparum; Pyrimidinones; Quinazolines; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Toxicity Tests, Acute

2006
American Chemical Society--233rd National Meeting. Kinesin spindle protein inhibitors. 25-29 March 2007, Chicago, IL, USA.
    IDrugs : the investigational drugs journal, 2007, Volume: 10, Issue:5

    Topics: Animals; Antineoplastic Agents; Benzamides; Drug Delivery Systems; Drug Design; Drug Screening Assays, Antitumor; Drugs, Investigational; Humans; Kinesins; Neoplasms; Pyrimidinones; Quinazolines; Spindle Apparatus

2007
Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Aug-31, Volume: 107, Issue:35

    Topics: Adenine; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Catalytic Domain; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Class I Phosphatidylinositol 3-Kinases; Dioxoles; Fibroblasts; Humans; Immunoprecipitation; Morpholines; Mutation; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Subunits; Pyrimidinones; Quinazolines; Thiazolidinediones; Transfection

2010
Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 337, Issue:2

    Topics: Adenine; Blotting, Western; Extracellular Matrix; Fibroblasts; Fibronectins; Humans; Hydrazones; Interleukin-6; Isoenzymes; Mesenchymal Stem Cells; Mitochondria; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyrimidinones; Quinazolines; Respiratory System; Substrate Specificity; Sulfonamides; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

2011
Inhibition of the growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib.
    Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; ErbB Receptors; Humans; Lapatinib; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Neoplasm Transplantation; Pancreatic Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Quinazolines; Receptor, ErbB-2; Signal Transduction

2013
High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma.
    BMC cancer, 2013, Oct-02, Volume: 13

    Topics: Aged; Aged, 80 and over; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Follow-Up Studies; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Naphthalenes; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Niacinamide; Pancreatic Neoplasms; Prognosis; Pyrimidinones; Quinazolines; Sirtuin 1

2013
Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling.
    Cancer research, 2014, Jun-15, Volume: 74, Issue:12

    Topics: Acetamides; Aminopyridines; Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Synergism; Erlotinib Hydrochloride; Feedback, Physiological; Female; Humans; MAP Kinase Kinase Kinases; Mice; Mice, Nude; Morpholines; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyrimidinones; Quinazolines; ras Proteins; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Sulfonamides; Tankyrases; Thiazoles; Xenograft Model Antitumor Assays

2014
Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
    Acta crystallographica. Section D, Biological crystallography, 2014, Volume: 70, Issue:Pt 10

    Topics: Benzamides; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Protein Conformation; Pyrimidinones; Quinazolines; Tankyrases

2014
Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2.
    Oncotarget, 2015, Feb-10, Volume: 6, Issue:4

    Topics: Apoptosis; Breast Neoplasms; Cell Hypoxia; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Dual Specificity Phosphatase 2; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Kaplan-Meier Estimate; Lapatinib; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridones; Pyrimidinones; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction

2015
Trametinib with or without vemurafenib in BRAF mutated non-small cell lung cancer.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Erlotinib Hydrochloride; G1 Phase; Humans; Indoles; Lung Neoplasms; MAP Kinase Signaling System; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Pyridones; Pyrimidinones; Quinazolines; Sulfonamides; Up-Regulation; Vemurafenib

2015
Profound blockade of T cell activation requires concomitant inhibition of different class I PI3K isoforms.
    Immunologic research, 2015, Volume: 62, Issue:2

    Topics: Adenine; Apoptosis; Cell Differentiation; Class I Phosphatidylinositol 3-Kinases; Cytokines; Enzyme Inhibitors; Humans; Immunophenotyping; Inhibitory Concentration 50; Isoenzymes; Lymphocyte Activation; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidinones; Quinazolines; T-Lymphocytes

2015
EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition.
    International journal of oncology, 2015, Volume: 47, Issue:2

    Topics: Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Humans; Lapatinib; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mutation; Phosphorylation; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Quinazolines; Receptor, ErbB-2; Stomach Neoplasms

2015
Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni.
    Parasites & vectors, 2015, Aug-13, Volume: 8

    Topics: Animals; Antineoplastic Agents; Drug Repositioning; Inhibitory Concentration 50; Mice; Piperidines; Pyridones; Pyrimidinones; Quinazolines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides

2015
Synthesis, Polymorphism, and Insecticidal Activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate Against Anopheles arabiensis Mosquito.
    Chemical biology & drug design, 2016, Volume: 88, Issue:1

    Topics: Animals; Anopheles; Drug Design; Female; Hydrogen Bonding; Insect Repellents; Insecticides; Larva; Linear Models; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Murinae; Pyrimidines; Pyrimidinones; Quinazolines; Quinazolinones; Stereoisomerism; Survival Analysis; X-Ray Diffraction

2016
Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.
    Nature, 2016, 09-01, Volume: 537, Issue:7618

    Topics: Alleles; Allosteric Regulation; Cell Line; Enzyme Stability; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Models, Molecular; Mutation; Neoplasms; Oncogenes; Phosphorylation; Protein Binding; Protein Conformation; Protein Multimerization; Protein Serine-Threonine Kinases; Pyridones; Pyrimidinones; Quinazolines; raf Kinases; ras Proteins

2016
Addition of the p110α inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:11

    Topics: Aminopyridines; Animals; Antibodies; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Humans; Lapatinib; Mice; Morpholines; ortho-Aminobenzoates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; PTEN Phosphohydrolase; Pyrimidinones; Quinazolines; Receptor, ErbB-2; Thiazoles; Xenograft Model Antitumor Assays

2016
Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells.
    Journal of proteome research, 2016, 12-02, Volume: 15, Issue:12

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Fibroblast Growth Factor 2; Gefitinib; Humans; Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Phosphopeptides; Protein Kinase Inhibitors; Proteome; Proteomics; Pyridones; Pyrimidinones; Quinazolines

2016
Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.
    Journal of medicinal chemistry, 2017, 01-26, Volume: 60, Issue:2

    Topics: Animals; Cartilage; Cattle; Chelating Agents; Collagen; Drug Design; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Pyrimidines; Pyrimidinones; Quinazolines; Thiophenes; Triazoles; Zinc

2017
Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: ADP Ribose Transferases; Bacterial Toxins; Dose-Response Relationship, Drug; Molecular Structure; Poly(ADP-ribose) Polymerase Inhibitors; Pseudomonas aeruginosa; Pyrimidinones; Quinazolines; Structure-Activity Relationship

2018
Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation.
    Biochimica et biophysica acta. General subjects, 2019, Volume: 1863, Issue:3

    Topics: Adenine; Animals; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Chromones; Down-Regulation; Ferritins; Glioma; Humans; Iron; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Pyrimidinones; Quinazolines; Rats; Thiazolidinediones; Up-Regulation

2019
Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-
    Journal of Asian natural products research, 2020, Volume: 22, Issue:1

    Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Humans; Indole Alkaloids; Lung Neoplasms; Molecular Structure; Pyrimidinones; Quinazolines; Structure-Activity Relationship

2020
Identifying the ErbB/MAPK Signaling Cascade as a Therapeutic Target in Canine Bladder Cancer.
    Molecular pharmacology, 2019, Volume: 96, Issue:1

    Topics: Animals; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dog Diseases; Dogs; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; HT29 Cells; Humans; MAP Kinase Signaling System; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Quinazolines; Urinary Bladder Neoplasms; Vemurafenib

2019
Combined VEGFR and MAPK pathway inhibition in angiosarcoma.
    Scientific reports, 2021, 04-30, Volume: 11, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hemangiosarcoma; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Prognosis; Pyridones; Pyrimidinones; Quinazolines; Transcriptome; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2021
A novel treatment strategy for lapatinib resistance in a subset of HER2-amplified gastric cancer.
    BMC cancer, 2021, Aug-16, Volume: 21, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Mice; Mice, Inbred NOD; Mice, SCID; Pyridones; Pyrimidines; Pyrimidinones; Quinazolines; Receptor, ErbB-2; Stomach Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2021