quinazolines has been researched along with pyrimethamine in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (75.00) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 1 (3.57) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rossan, RN; Schmidt, LH | 1 |
| Schmidt, LH | 2 |
| Hynes, JB; McCullough, JL; Weinstein, GD | 1 |
| Bunni, M; Dilwith, R; Galivan, J; Johnson, TB; Nair, MG; Priest, DG; Rhee, MS | 1 |
| Chastang, C; Derouin, F | 1 |
| Cranford, SK; Fernandes, DJ | 1 |
| Allegra, CJ; Chabner, BA; Drake, J; Kovacs, JA; Lunde, M; Masur, H; Parrillo, JE; Swan, JC | 1 |
| Galivan, J; Nimec, Z; Rhee, M | 1 |
| Boschelli, D; Galivan, J; Kerwar, SS; Nimec, Z; Oronsky, AL; Rhee, M | 1 |
| Allegra, CJ; Chabner, BA; Drake, JC; Kovacs, JA; Masur, H; Parrillo, JE; Swan, JC | 1 |
| Kovacs, JA; Masur, H | 1 |
| Jaffe, JJ; McCormack, JJ; Meymarian, E | 1 |
| Ashton, WT; Hynes, JB | 1 |
| Elslager, EF | 1 |
| Modest, EJ; Rosowsky, A | 1 |
| Hawks, GH; McKillop, A; Shvo, Y; Taylor, EC | 1 |
| Cheng, CC; Roth, B | 1 |
| Diddens, H; Jackson, RC; Niethammer, D | 2 |
| Baccanari, DP; Boytos, CM; Chan, JH; Hong, JS; Joyner, SS; Kuyper, LF; Rudolph, SK; Tansik, RL | 1 |
| Chen, XH; Hu, YM | 1 |
| Bagnara, AS; Nott, SE | 1 |
| Aboulwafa, OM; el-Azzouni, MZ; el-Mansoury, ST; el-Tombary, AA; Ismail, KA; Omar, AM | 1 |
| Deng, S; Hu, Y | 1 |
| ZACH, J | 1 |
| Assaraf, YG; Berman, B; Bram, E; Ifergan, I; Jansen, G; Shafran, A | 1 |
| Brun, R; Chitnumsub, P; Dartois, V; Diagana, TT; Goh, A; Kamchonwongpaisan, S; Keller, TH; Kiara, SM; Lakshminarayana, SB; Ma, NL; Maneeruttanarungroj, C; Nzila, A; Rottmann, M; Taweechai, S; Weaver, M; Wittlin, S; Wong, J; Yeung, BK; Yuthavong, Y; Zou, B | 1 |
4 review(s) available for quinazolines and pyrimethamine
| Article | Year |
|---|---|
Pneumocystis carinii pneumonia: therapy and prophylaxis.
Topics: Acquired Immunodeficiency Syndrome; Anti-Bacterial Agents; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Pentamidine; Pneumonia, Pneumocystis; Pyrimethamine; Quinazolines; Recurrence; Sulfadiazine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1988 |
Progress in malaria chemotherapy. 1. Repository antimalarial drugs.
Topics: Acridines; Animals; Antimalarials; Chemical Phenomena; Chemistry; Dapsone; Delayed-Action Preparations; Guanidines; Injections; Methanol; Mice; Plasmodium; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Pyrimethamine; Quinazolines; Quinolines; Sulfonamides; Sulfones | 1969 |
Synthesis and biological activity of tricyclic antifolate compounds with fixed geometry.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma; Cell Line; Chickens; Enterococcus faecalis; Folic Acid Antagonists; Humans; Leukemia L1210; Liver; Malaria; Mammary Neoplasms, Experimental; Mice; Mouth Neoplasms; Pyrimethamine; Quinazolines; Structure-Activity Relationship | 1971 |
Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines.
Topics: Amino Acid Sequence; Animals; Folic Acid Antagonists; Glutamates; Glutamic Acid; Malaria; Mathematics; Methotrexate; Microbial Sensitivity Tests; Models, Chemical; Pyrimethamine; Pyrimidines; Quinazolines; Stereoisomerism; Triazines | 1982 |
24 other study(ies) available for quinazolines and pyrimethamine
| Article | Year |
|---|---|
Studies on the 2,4-diamino-6 substituted quinazolines. I. Antimalarial activities of 2,4-diamino-6-[(3,4-dichlorobenzyl)-nitrosoamino]-quinazoline (CI-679) as exhibited in rhesus monkeys infected with the Ro or Ro/PM strains of Plasmodium cynomolgi.
Topics: Animals; Anopheles; Drug Resistance, Microbial; Female; Haplorhini; Macaca mulatta; Malaria; Male; Plasmodium; Pyrimethamine; Quinazolines | 1979 |
Studies on the 2,4-diamino-6-substituted quinazolines. II. Activities of selected derivatives against infections with various drug-susceptible and drug-resistant strains of Plasmodium falciparum and Plasmodium vivax in owl monkeys.
Topics: Animals; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine; Drug Resistance, Microbial; Female; Haplorhini; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Quinazolines | 1979 |
Studies on the 2,4-diamino-6-substituted quinazolines. III. The capacity of sulfadiazine to enhance the activities of WR-158,122 and WR-159,412 against infections with various drug-susceptible and drug-resistant strains of Plasmodium falciparum and Plasmo
Topics: Animals; Aotus trivirgatus; Drug Combinations; Drug Resistance, Microbial; Female; Haplorhini; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Quinazolines; Sulfadiazine | 1979 |
In vitro screening of biochemical activity of folic acid antagonists in skin.
Topics: Animals; Animals, Newborn; Chlorobenzenes; Depression, Chemical; DNA; Folic Acid Antagonists; Methotrexate; Psoriasis; Pyrimethamine; Pyrimidines; Quinazolines; Rats; Skin; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1977 |
The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Folic Acid; Folic Acid Antagonists; Kinetics; Liver Neoplasms, Experimental; Pyrimethamine; Quinazolines; Rats; Thymidylate Synthase; Trimetrexate | 1989 |
In vitro effects of folate inhibitors on Toxoplasma gondii.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Folic Acid Antagonists; Microbial Sensitivity Tests; Pyrimethamine; Pyrimidines; Quinazolines; Sulfamethoxazole; Sulfisoxazole; Toxoplasma; Trimethoprim; Trimetrexate | 1989 |
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
Topics: Deoxyguanine Nucleotides; DNA; DNA Polymerase II; Dose-Response Relationship, Drug; Floxuridine; Folic Acid Antagonists; Humans; Leukemia; Pyrimethamine; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides | 1986 |
Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.
Topics: Animals; Cells, Cultured; Drug Therapy, Combination; Folic Acid Antagonists; Macrophages; Mice; Mice, Inbred BALB C; Pentamidine; Pyrimethamine; Quinazolines; Sulfadiazine; Toxoplasma; Toxoplasmosis, Animal; Trimethoprim; Trimetrexate | 1987 |
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Methotrexate; Pyrimethamine; Quinazolines; Rats; Thymidine; Thymidylate Synthase; Trimetrexate | 1987 |
Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.
Topics: Acyltransferases; Animals; Drug Synergism; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Liver Neoplasms, Experimental; Phosphoribosylglycinamide Formyltransferase; Pyrimethamine; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Trimetrexate; Tumor Cells, Cultured | 1988 |
Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate.
Topics: Animals; Folic Acid Antagonists; Mice; Mice, Inbred BALB C; Pneumocystis; Pyrimethamine; Pyrimidines; Quinazolines; Rats; Rats, Inbred Strains; Toxoplasma; Trimetrexate | 1988 |
Comparative properties of schistosomal and filarial dihydrofolate reductases.
Topics: Anthelmintics; Chromatography, Gel; Eukaryota; Filarioidea; Folic Acid Antagonists; Molecular Weight; NADP; Pyrimethamine; Quinazolines; Schistosoma mansoni; Structure-Activity Relationship; Suramin; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1972 |
Synthesis of 5-substituted quinazolines as potential antimalarial agents.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Liver; Malaria; Mice; Plasmodium berghei; Pyrimethamine; Quinazolines; Rats; Structure-Activity Relationship; Sulfides | 1973 |
Heterocyclic synthesis from o-amino-nitriles. 28. Synthesis of some benzo(f)- and benzo(h)quinazolines.
Topics: Amines; Chemistry, Organic; Cyanides; Folic Acid Antagonists; Organic Chemistry Phenomena; Pyrimethamine; Quinazolines | 1967 |
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; Structure-Activity Relationship; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1983 |
Resistance of human tumor cell lines to antifolates.
Topics: B-Lymphocytes; Biological Transport; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Karyotyping; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1984 |
Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines.
Topics: Animals; Antifungal Agents; Candida albicans; Drug Design; Folic Acid Antagonists; Humans; Mice; Pyrimethamine; Pyrimidines; Quinazolines; Recombinant Proteins; Structure-Activity Relationship; Trimethoprim; Trimetrexate | 1995 |
[Effects of four drugs on intraerythrocytic Plasmodium yoelii of early and late stages].
Topics: Animals; Antimalarials; Erythrocytes; Female; Male; Metronidazole; Mice; Perphenazine; Plasmodium yoelii; Pyrimethamine; Quinazolines | 1993 |
The toxicity of antifolates in Babesia bovis.
Topics: Animals; Babesia bovis; Folic Acid; Folic Acid Antagonists; Pyrimethamine; Pyrimidines; Quinazolines; Trimethoprim; Trimetrexate | 1993 |
Novel triazolo[4,3-a]quinazolinone and bis-triazolo[4,3-a:4,3'-c]quinazolines: synthesis and antitoxoplasmosis effect.
Topics: Animals; Anti-Infective Agents; Coccidiostats; Mice; Pyrimethamine; Quinazolines; Quinazolinones; Toxoplasma; Toxoplasmosis, Animal; Triazoles | 1999 |
[Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro].
Topics: Animals; Anopheles; Antimalarials; Cellular Structures; Ethanolamines; Malaria; Membranes; Parasitic Sensitivity Tests; Phospholipids; Plasmodium falciparum; Plasmodium yoelii; Protozoan Proteins; Pyrimethamine; Quinazolines | 1999 |
[The effect of 2, 4-diamino-5-p-chlorphenyl-6-ethyl-perimidine (daraprim) on the hemopoietic system].
Topics: Antimalarials; Hematopoietic System; Pyrimethamine; Quinazolines | 1956 |
Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Lipids; Molecular Structure; Mutation; Neoplasm Proteins; Paclitaxel; Pyrimethamine; Pyrimidines; Quinazolines; Rhodamines; Transfection; Trimetrexate | 2006 |
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Drug Resistance; Female; Folic Acid Antagonists; Humans; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Models, Molecular; Mutation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Quinazolines; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase | 2010 |