Page last updated: 2024-08-21

quinazolines and pteridines

quinazolines has been researched along with pteridines in 23 studies

Research

Studies (23)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (30.43)	18.7374
1990's	3 (13.04)	18.2507
2000's	2 (8.70)	29.6817
2010's	9 (39.13)	24.3611
2020's	2 (8.70)	2.80

Authors

Authors	Studies
Colman, PD; Jones, TR; Moran, RG	1
Lakshmanan, MR; Narindrasorasak, S	1
Canfield, CJ; Rozman, RS	1
Dunlap, RB; Ellis, PD; Lyon, JA	1
Ashton, WT; Hynes, JB; Walker, FC	1
Diekmann, HJ; Hoffmeister, W	1
Dewey, VC; Kidder, GW	1
Hynes, JB; Queener, SF; Rosowsky, A	1
Beverley, SM; Hardy, LW; Matthews, W; Nare, B	1
Aqvist, J; Graffner-Nordberg, M; Hallberg, A; Hansson, T; Marelius, J	1
Rosowsky, A; Vaidya, CM; Wright, JE	1
Kokwaro, G; Marsh, K; Mberu, E; Nduati, E; Nzila, A; Ommeh, S; Rosowsky, A	1
Foley, EA; Kapoor, TM; Maldonado, M	1
Bottegoni, G; Garuti, L; Roberti, M	1
Albitar, L; Brachova, P; Dai, D; Ianzini, F; Kosmacek, EA; Laidler, LL; Leslie, KK; Liu, D; Mackey, MA; Meng, X; Wang, X; Xiong, Z; Yang, S; Zhang, Y; Zhu, D	1
Eibl, JK; Ross, GM; Strasser, BC	1
Ambudkar, SV; Cheng, HW; Hsiao, SH; Huang, YH; Li, YQ; Luo, SY; Sim, HM; Tuo, WC; Wu, CP	1
Bai, F; Ding, K; Ku, X; Li, H; Liu, X; Tu, Z; Xu, Y; Zhang, L; Zhao, Z; Zhou, W	1
Chow, JP; Hong, MJ; Li, J; Ma, HT; Mak, JP; Man, WY; Poon, RY	1
De Smet, M; Herremans, C; Liu, D; Machiels, JP; Peeters, M; Pilz, K; Rottey, S; Specenier, P; Strelkowa, N; Surmont, V	1
Ross, GM; Scott, JA; Sheffield, KS; Vohra, R	1
Deng, Z; Du, Z; Li, X; Tao, Z; Wang, H; Zhou, Y	1
Azimi, A; Goroshchuk, O; Jafari, R; Kolosenko, I; Kunold, E; Palm-Apergi, C; Pirmoradian, M; Vidarsdottir, L	1

Reviews

1 review(s) available for quinazolines and pteridines

Article	Year
Polo-like kinases inhibitors. Current medicinal chemistry, 2012, Volume: 19, Issue:23 Topics: Binding, Competitive; Catalytic Domain; Cell Cycle Proteins; DNA Repair; Humans; Neoplasms; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Pyridines; Quinazolines; Thiophenes	2012

Trials

2 trial(s) available for quinazolines and pteridines

Article	Year
Clinical testing of new antimalarial compounds. Bulletin of the World Health Organization, 1974, Volume: 50, Issue:3-4 Topics: Amino Acids; Antimalarials; Clinical Trials as Topic; Drug Evaluation; Drug Resistance; Guanidines; Humans; Malaria; Naphthoquinones; Phenanthrenes; Plasmodium falciparum; Pteridines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Sulfones; Triazines; Xylenes	1974
A phase I study of volasertib combined with afatinib, in advanced solid tumors. Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:4 Topics: Administration, Oral; Adult; Afatinib; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Humans; Infusions, Intravenous; Male; Neoplasm Metastasis; Neoplasm Staging; Neoplasms; Neutropenia; Protein Kinase Inhibitors; Pteridines; Quinazolines; Severity of Illness Index; Thrombocytopenia	2015

Article

Year

Clinical testing of new antimalarial compounds.

Bulletin of the World Health Organization, 1974, Volume: 50, Issue:3-4

Topics: Amino Acids; Antimalarials; Clinical Trials as Topic; Drug Evaluation; Drug Resistance; Guanidines; Humans; Malaria; Naphthoquinones; Phenanthrenes; Plasmodium falciparum; Pteridines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Sulfones; Triazines; Xylenes

1974

A phase I study of volasertib combined with afatinib, in advanced solid tumors.

Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:4

Topics: Administration, Oral; Adult; Afatinib; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Humans; Infusions, Intravenous; Male; Neoplasm Metastasis; Neoplasm Staging; Neoplasms; Neutropenia; Protein Kinase Inhibitors; Pteridines; Quinazolines; Severity of Illness Index; Thrombocytopenia

2015

Other Studies

20 other study(ies) available for quinazolines and pteridines

Article	Year
Relative substrate activities of structurally related pteridine, quinazoline, and pyrimidine analogs for mouse liver folylpolyglutamate synthetase. Molecular pharmacology, 1989, Volume: 36, Issue:5 Topics: Amines; Animals; Kinetics; Liver; Mice; Peptide Synthases; Pteridines; Pyrimidines; Quinazolines; Structure-Activity Relationship; Substrate Specificity	1989
Conversion of retinyl methyl ether into retinol in the rat in vitro. Biochemistry, 1972, Feb-01, Volume: 11, Issue:3 Topics: Aluminum; Animals; Edetic Acid; Enzyme Activation; Ethers; Intestinal Mucosa; Kinetics; Lithium; Liver; Magnesium; Male; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; NADP; Oxygenases; Pteridines; Quinazolines; Rats; Subcellular Fractions; Tritium; Vitamin A	1972
Assignment of the carbon-13 nuclear magnetic resonance spectrum of folic acid. Biochemistry, 1973, Jun-19, Volume: 12, Issue:13 Topics: Aminobenzoates; Benzamides; Carbon Isotopes; Chemical Phenomena; Chemistry; Deuterium; Folic Acid; Glutamates; Magnetic Resonance Spectroscopy; Protons; Pteridines; Purines; Quinazolines; Quinoxalines; Ribonucleosides	1973
Quinazolines as inhibitors of dihydrofolate reductase. 1. Journal of medicinal chemistry, 1973, Volume: 16, Issue:6 Topics: Animals; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Liver; Pteridines; Pyrimidines; Quinazolines; Rats; Structure-Activity Relationship	1973
[Diuretic therapy without potassium loss]. Die Medizinische Welt, 1971, Sep-18, Volume: 38 Topics: Diuresis; Humans; Potassium; Pteridines; Quinazolines	1971
2,4-diamino-5, 6,7,8-tetrahydroquinazoline, a new pteridine antagonist. Biochemical and biophysical research communications, 1969, Feb-21, Volume: 34, Issue:4 Topics: Animals; Depression, Chemical; Eukaryota; Folic Acid; Growth; Pteridines; Pterins; Quinazolines; Thymidine; Thymine	1969
Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:1 Topics: Animals; Enzyme Inhibitors; Folic Acid Antagonists; Liver; Pneumocystis; Pteridines; Quinazolines; Rats; Structure-Activity Relationship; Toxoplasma	1995
Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways. Experimental parasitology, 1997, Volume: 87, Issue:3 Topics: Animals; Cell Division; Drug Resistance; Folic Acid Antagonists; Humans; Leishmania; Methotrexate; Microbial Sensitivity Tests; Multienzyme Complexes; Mutation; Oxidoreductases; Pteridines; Pyrimidines; Quinazolines; Species Specificity; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase	1997
Computation of affinity and selectivity: binding of 2,4-diaminopteridine and 2,4-diaminoquinazoline inhibitors to dihydrofolate reductases. Journal of computer-aided molecular design, 1998, Volume: 12, Issue:2 Topics: Computer Simulation; Drug Design; Folic Acid Antagonists; Humans; Mathematical Computing; Models, Molecular; Protein Binding; Pteridines; Quinazolines; Substrate Specificity; Tetrahydrofolate Dehydrogenase	1998
Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523). Journal of medicinal chemistry, 2002, Apr-11, Volume: 45, Issue:8 Topics: Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Ornithine; Pteridines; Pterins; Quinazolines; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	2002
In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:10 Topics: Animals; Antimalarials; Dapsone; Dihydropteroate Synthase; Drug Resistance; Folic Acid Antagonists; Plasmodium falciparum; Pteridines; Quinazolines; Saccharomyces cerevisiae; Tetrahydrofolate Dehydrogenase	2004
Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase. Nature cell biology, 2011, Aug-28, Volume: 13, Issue:10 Topics: Aurora Kinase B; Aurora Kinases; Benzamides; Cell Cycle Proteins; Chromosome Segregation; HeLa Cells; Humans; Indoles; Kinetochores; Leupeptins; Microscopy, Fluorescence; Microtubules; Nocodazole; Phosphorylation; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Quinazolines; Recombinant Fusion Proteins; RNA Interference; Sulfonamides; Time Factors; Transfection; Tumor Suppressor Proteins	2011
Induction of mitotic cell death by overriding G2/M checkpoint in endometrial cancer cells with non-functional p53. Gynecologic oncology, 2013, Volume: 128, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Endometrial Neoplasms; Female; G2 Phase Cell Cycle Checkpoints; Gefitinib; Humans; M Phase Cell Cycle Checkpoints; Mice; Mice, Nude; Mitosis; Paclitaxel; Pteridines; Quinazolines; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2013
Identification of novel pyrazoloquinazolinecarboxilate analogues to inhibit nerve growth factor in vitro. European journal of pharmacology, 2013, May-15, Volume: 708, Issue:1-3 Topics: Animals; Cell Differentiation; Flavins; Heterocyclic Compounds, 3-Ring; Models, Molecular; Nerve Growth Factor; Neurites; PC12 Cells; Pteridines; Pyrazoles; Quinazolines; Rats	2013
Human ABCB1 (P-glycoprotein) and ABCG2 mediate resistance to BI 2536, a potent and selective inhibitor of Polo-like kinase 1. Biochemical pharmacology, 2013, Oct-01, Volume: 86, Issue:7 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Cycle Proteins; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; G2 Phase Cell Cycle Checkpoints; Humans; Lapatinib; Mice; Neoplasm Proteins; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Pyrimidines; Quinazolines	2013
Discovery of pteridin-7(8H)-one-based irreversible inhibitors targeting the epidermal growth factor receptor (EGFR) kinase T790M/L858R mutant. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Computational Biology; Drug Discovery; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mice; Mice, Nude; Mice, SCID; Models, Chemical; Molecular Structure; Mutation; Protein Kinase Inhibitors; Pteridines; Quinazolines; Xenograft Model Antitumor Assays	2013
Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe. Oncotarget, 2015, Apr-20, Volume: 6, Issue:11 Topics: Animals; Antineoplastic Agents; Aurora Kinase A; Aurora Kinase B; Carcinoma; Cell Cycle Proteins; Cyclohexanecarboxylic Acids; Drug Synergism; Female; HeLa Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mitosis; Molecular Targeted Therapy; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Organophosphates; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Quinazolines; Thiazoles; Tumor Cells, Cultured	2015
Using surface plasmon resonance spectroscopy to characterize the inhibition of NGF-p75(NTR) and proNGF-p75(NTR) interactions by small molecule inhibitors. Pharmacological research, 2016, Volume: 103 Topics: Flavins; Heterocyclic Compounds, 3-Ring; Nerve Growth Factor; Pteridines; Quinazolines; Receptor, Nerve Growth Factor; Surface Plasmon Resonance	2016
Dual inhibition of Src and PLK1 regulate stemness and induce apoptosis through Notch1-SOX2 signaling in EGFRvIII positive glioma stem cells (GSCs). Experimental cell research, 2020, 11-01, Volume: 396, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodioxoles; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Injections, Intraventricular; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Quinazolines; Receptor, Notch1; Signal Transduction; SOXB1 Transcription Factors; src-Family Kinases; Stereotaxic Techniques; Survival Analysis; Tumor Burden; Xenograft Model Antitumor Assays	2020
Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:7 Topics: Antigens, Surface; Cell Cycle Proteins; Cytarabine; Fatty Acids; HL-60 Cells; Humans; Immunity; Jurkat Cells; Leukemia, Myeloid, Acute; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteome; Proto-Oncogene Proteins; Pteridines; Pyrazoles; Quinazolines	2021