Compounds > quinazolines

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quinazolines and piritrexim

quinazolines has been researched along with piritrexim in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (40.00)	18.7374
1990's	7 (46.67)	18.2507
2000's	2 (13.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fleming, GF; Schilsky, RL	1
Assaraf, YG; Schimke, RT; Sharma, RC	1
Bartlett, MS; Durkin, MM; Jay, MA; Queener, SF; Smith, JW	1
Chastang, C; Derouin, F	1
Assaraf, YG; Molina, A; Schimke, RT	1
Besserer, JA; Fry, DW; Klohs, WD; Steinkampf, RW	1
Allegra, CJ; Chabner, BA; Drake, JC; Kovacs, JA; Masur, H; Parrillo, JE; Swan, JC	1
Besserer, JA; Fry, DW	1
Baccanari, DP; Boytos, CM; Chan, JH; Hong, JS; Joyner, SS; Kuyper, LF; Rudolph, SK; Tansik, RL	1
Bagnara, AS; Nott, SE	1
Allegra, CJ; Takimoto, CH	1
Takimoto, CH	1
Forsch, RA; Papoulis, AT; Queener, SF; Rosowsky, A	1
Chen, H; Rosowsky, A	1
Assaraf, YG; Berman, B; Bram, E; Ifergan, I; Jansen, G; Shafran, A	1

Reviews

3 review(s) available for quinazolines and piritrexim

Article	Year
Antifolates: the next generation. Seminars in oncology, 1992, Volume: 19, Issue:6 Topics: Aminopterin; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Drug Evaluation; Folic Acid Antagonists; Forecasting; Humans; Neoplasms; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate	1992
New antifolates in clinical development. Oncology (Williston Park, N.Y.), 1995, Volume: 9, Issue:7 Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Drugs, Investigational; Folic Acid Antagonists; Humans; Neoplasms; Pyrimidines; Quinazolines; Thiophenes; Trimetrexate	1995
Antifolates in clinical development. Seminars in oncology, 1997, Volume: 24, Issue:5 Suppl 18 Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase	1997

Other Studies

12 other study(ies) available for quinazolines and piritrexim

Article	Year
A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells. Cancer research, 1991, Jun-01, Volume: 51, Issue:11 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Cell Line; Cricetinae; Drug Resistance; Folic Acid Antagonists; Gene Amplification; Membrane Glycoproteins; Methotrexate; Phenotype; Pyrimidines; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate; Verapamil	1991
Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection. Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:9 Topics: Animals; Cells, Cultured; Folic Acid Antagonists; Humans; Pneumocystis; Pneumonia, Pneumocystis; Pyrimidines; Quinazolines; Rats; RNA; Trimetrexate	1987
In vitro effects of folate inhibitors on Toxoplasma gondii. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:10 Topics: Animals; Enzyme-Linked Immunosorbent Assay; Folic Acid Antagonists; Microbial Sensitivity Tests; Pyrimethamine; Pyrimidines; Quinazolines; Sulfamethoxazole; Sulfisoxazole; Toxoplasma; Trimethoprim; Trimetrexate	1989
Sequential amplification of dihydrofolate reductase and multidrug resistance genes in Chinese hamster ovary cells selected for stepwise resistance to the lipid-soluble antifolate trimetrexate. The Journal of biological chemistry, 1989, Nov-05, Volume: 264, Issue:31 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cricetinae; Drug Resistance; Fluorescein; Fluoresceins; Folic Acid Antagonists; Gene Amplification; Gene Expression; Membrane Glycoproteins; Methotrexate; Pyrimidines; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate	1989
Cross resistance of pleiotropically drug resistant P338 leukemia cells to the lipophilic antifolates trimetrexate and BW 301U. Cancer letters, 1986, Volume: 31, Issue:3 Topics: Animals; Drug Resistance; Folic Acid Antagonists; Leukemia P388; Methotrexate; Mice; Pyrimidines; Quinazolines; Trimetrexate	1986
Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate. Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:4 Topics: Animals; Folic Acid Antagonists; Mice; Mice, Inbred BALB C; Pneumocystis; Pyrimethamine; Pyrimidines; Quinazolines; Rats; Rats, Inbred Strains; Toxoplasma; Trimetrexate	1988
Characterization of trimetrexate transport in human lymphoblastoid cells and development of impaired influx as a mechanism of resistance to lipophilic antifolates. Cancer research, 1988, Dec-15, Volume: 48, Issue:24 Pt 1 Topics: Antimetabolites, Antineoplastic; Azides; Cell Line; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Humans; Lymphocytes; Pyrimidines; Quinazolines; Sodium Azide; Trimetrexate	1988
Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines. Journal of medicinal chemistry, 1995, Sep-01, Volume: 38, Issue:18 Topics: Animals; Antifungal Agents; Candida albicans; Drug Design; Folic Acid Antagonists; Humans; Mice; Pyrimethamine; Pyrimidines; Quinazolines; Recombinant Proteins; Structure-Activity Relationship; Trimethoprim; Trimetrexate	1995
The toxicity of antifolates in Babesia bovis. International journal for parasitology, 1993, Volume: 23, Issue:3 Topics: Animals; Babesia bovis; Folic Acid; Folic Acid Antagonists; Pyrimethamine; Pyrimidines; Quinazolines; Trimethoprim; Trimetrexate	1993
Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim. Journal of medicinal chemistry, 1999, Mar-25, Volume: 42, Issue:6 Topics: Animals; Antifungal Agents; Antineoplastic Agents; Antiprotozoal Agents; Cell Line; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Liver; Lung; Mice; Pneumocystis; Pyrimidines; Quinazolines; Rats; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis, Animal; Tumor Cells, Cultured	1999
A novel method of synthesis of 2,4-diamino-6-arylmethylquinazolines using palladium(0)-catalyzed organozinc chemistry. The Journal of organic chemistry, 2001, Nov-02, Volume: 66, Issue:22 Topics: Catalysis; Enzyme Inhibitors; Folic Acid Antagonists; Palladium; Pyrimidines; Quinazolines; Zinc	2001
Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:6 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Lipids; Molecular Structure; Mutation; Neoplasm Proteins; Paclitaxel; Pyrimethamine; Pyrimidines; Quinazolines; Rhodamines; Transfection; Trimetrexate	2006