quinazolines has been researched along with pd168393 in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (34.15) | 29.6817 |
| 2010's | 26 (63.41) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, JY; Hour, TC; Hsieh, MW; Huang, CY; Lin, CC; Lin, SR; Liu, GY; Pu, YS; Wang, CW | 1 |
| Gibson, NJ; Tolbert, LP | 1 |
| Boron, WF; Bouyer, P; Zhou, Y | 1 |
| Bader, JS; Bitok, JK; Bose, R; Cole, PA; Molina, H; Pandey, A; Patterson, AS; Periaswamy, B | 1 |
| Sanders, PW; Ying, WZ; Zhang, HG | 1 |
| Erschbamer, M; Olson, L; Pernold, K | 2 |
| Albrecht, M; Köhn, F; Mayerhofer, A; Weidinger, S; Zitta, K | 1 |
| Claasen, J; Sos, ML; Staratschek-Jox, A; Thomas, RK; Wolf, J; Zander, T | 1 |
| Boichot, E; Gillon, JY; Guénon, I; Lagente, V; Le Quément, C | 1 |
| Balk, SP; Didonato, M; Flatauer, L; Gray, NS; Hur, W; Jiang, X; Kim, S; Larson, B; Mason, DE; Nagle, A; Peters, EC; Suzuki, M; Valente, D; Velentza, A; Warmuth, M; Zagorska, A; Zhang, J | 1 |
| Arabshahi, A; Barnes, S; Carroll, SL; Moore, R; Prasain, JK | 1 |
| Burger, DE; Feng, Q; Hammoud, L; Lu, X | 1 |
| Ahmed, Z; Berry, M; Jacques, SJ; Logan, A | 1 |
| Ahmed, Z; Berry, M; Douglas, MR; Gonzalez, AM; Jacques, SJ; Leadbeater, WE; Logan, A; Morrison, KC | 1 |
| Chen, TH; Fischer, F; Getlik, M; Greulich, H; Heuckmann, JM; Heynck, S; Klüter, S; Koker, M; Pawar, VG; Peifer, M; Rabiller, M; Rauh, D; Reuter, C; Rode, HB; Ruddigkeit, L; Simard, JR; Sos, ML; Thomas, RK; Weiss, J; Yuza, Y | 1 |
| Gutkind, JS; Hoffman, MP; Knox, SM; Lombaert, IM; Reed, X; Vitale-Cross, L | 1 |
| Maffei, VJ; Newton-West, M; Swerlick, RA; White, KJ | 1 |
| Cartee, TV; Pollack, BP; Sapkota, B | 1 |
| Chung, YL; Pui, NN | 1 |
| Sharp, K; Steward, O; Yee, KM | 1 |
| Byer, S; Carroll, SL; Kaza, N; Kohli, L; Lavalley, NJ; Roth, KA; Turner, KL | 1 |
| Bradley, M; Homey, B; Nordenskjöld, M; Pivarcsi, A; Sääf, A; Tengvall-Linder, M; Wahlgren, CF; Winge, MC | 1 |
| Feng, Z; Ju, P; Yeap, Y; Zhang, S | 1 |
| Lu, C; Mi, LZ; Schürpf, T; Springer, TA; Walz, T | 1 |
| Anderson, PN; Bolsover, SR; Joy, MT; Leinster, VH; Vuononvirta, RE | 1 |
| Alfieri, RR; Bassi, M; Carmi, C; Cavazzoni, A; Galvani, E; Lodola, A; Mor, M; Petronini, PG; Rivara, S; Silva, C; Vacondio, F | 1 |
| Chang, C; Chen, CC; Chuang, WM; Hsieh, TF; Hung, XF; Lin, MH; Ma, WL; Shyr, CR; Tsai, YR; Zhang, C; Zhang, Q | 1 |
| Li, JJ; Li, ZW; Mao, XQ; Shi, GF; Wang, F; Wang, L; Wang, Q; Wu, JJ; Zhang, JP; Zou, J | 1 |
| Jiang, J; Li, K; Wu, X; Yao, P; Zhang, J | 1 |
| Gao, F; Liu, T; Manyande, A; Tian, X; Tian, Y; Xiang, H; Xiang, Y; Yang, H | 1 |
| Englund-Johansson, U; Jiao, Y; Kale, A; Novozhilova, E; Olivius, P | 1 |
| He, X; Kong, Y; Li, W; Xiao, M; Zhang, H | 1 |
| Compans, RW; Pollack, BP; Pulit-Penaloza, JA; Sapkota, B; Skountzou, I; Stein Esser, E | 1 |
| Gu, M; Hong, X; Liang, J; Lu, C; Sun, X; Tang, J; Wang, X; Xu, W; Yao, X; Zhong, T | 1 |
| Feng, Z; Ju, P; Owlanj, H; Tjandra, E; Yeap, Y; Zhang, S | 1 |
| Carbone, ML; Lulli, D; Pastore, S | 1 |
| Famulok, M; Hagelueken, G; Hannam, JS; Schiemann, O; Schmitz, A; Yin, DM | 1 |
| Choo, J; Chung, HY; Heo, G; Im, E; Jung, JH; Jung, Y; Kim, DH; Kim, MJ; Kim, SJ; Kim, W; Lee, Y; Moon, HR; Noh, TH; Son, S | 1 |
| Chen, JL; Ding, HL; Li, WB; Liu, BL; Liu, XG; Su, MZ; Xie, JC; Xu, YC; Yang, F; Zhan, HL; Zhou, X; Zhou, XF | 1 |
| Billiar, TR; Chen, L; Fan, EK; Fan, J; Lai, D; Li, Y; Scott, MJ; Tang, J; Wang, P; Wilson, MA; Wu, Q; Zhou, B | 1 |
41 other study(ies) available for quinazolines and pd168393
| Article | Year |
|---|---|
Epidermal growth factor receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer cells.
Topics: Adenocarcinoma; Androgens; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Combinations; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Gefitinib; Humans; Male; Paclitaxel; Prostatic Neoplasms; Quinazolines | 2006 |
Activation of epidermal growth factor receptor mediates receptor axon sorting and extension in the developing olfactory system of the moth Manduca sexta.
Topics: Amino Acid Sequence; Animals; Axons; ErbB Receptors; Humans; Immunohistochemistry; Manduca; Molecular Sequence Data; Neuroglia; Olfactory Receptor Neurons; Quinazolines; Sense Organs; Sequence Alignment; Smell | 2006 |
Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules.
Topics: Absorption; Animals; Bicarbonates; Carbon Dioxide; Dimethyl Sulfoxide; Enzyme Inhibitors; Female; Genistein; Imidazoles; Kidney Tubules, Proximal; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Rabbits; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction | 2006 |
Phosphoproteomic analysis of Her2/neu signaling and inhibition.
Topics: Amino Acid Sequence; Animals; Mass Spectrometry; Mice; Molecular Sequence Data; NIH 3T3 Cells; Phosphoproteins; Phosphorylation; Proteomics; Quinazolines; Receptor, ErbB-2; Signal Transduction; Transfection | 2006 |
EGF receptor activity modulates apoptosis induced by inhibition of the proteasome of vascular smooth muscle cells.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Boronic Acids; Bortezomib; Caspases; Cell Proliferation; Cells, Cultured; ErbB Receptors; Mitochondria; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protease Inhibitors; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyrazines; Quinazolines; Rats; RNA Interference | 2007 |
Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; ErbB Receptors; Female; In Situ Hybridization; Motor Activity; Pain; Pain Measurement; Psychomotor Performance; Quinazolines; Rats; Rats, Sprague-Dawley; Recovery of Function; Sensation; Serotonin; Spinal Cord Injuries; Time Factors; Tyrosine 3-Monooxygenase; Urinary Bladder | 2007 |
Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility.
Topics: Ejaculation; Enzyme Inhibitors; ErbB Receptors; Humans; Male; Microscopy, Immunoelectron; Oligopeptides; Quinazolines; Receptor, PAR-2; Reference Values; Semen; Sperm Motility; Spermatozoa; Tyrphostins | 2007 |
Expression of signaling mediators downstream of EGF-receptor predict sensitivity to small molecule inhibitors directed against the EGF-receptor pathway.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromones; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ErbB Receptors; Farnesyltranstransferase; Gefitinib; Humans; Lung Neoplasms; MAP Kinase Signaling System; Morpholines; Phosphatidylinositols; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); PTEN Phosphohydrolase; Quinazolines; ras Proteins; Sirolimus | 2008 |
MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.
Topics: Cell Line; ErbB Receptors; Genes, fos; Humans; Interleukin-8; Matrix Metalloproteinase 12; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Respiratory Mucosa; Tyrphostins | 2008 |
Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase.
Topics: Animals; Cysteine; ErbB Receptors; Mice; Molecular Structure; Morpholines; Protein-Tyrosine Kinases; Quinazolines; Sequence Homology, Amino Acid | 2008 |
A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum.
Topics: Animals; Chromatography, Liquid; Quinazolines; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling.
Topics: Animals; Animals, Newborn; Anthracenes; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Epidermal Growth Factor; ErbB Receptors; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Recombinant Proteins; Signal Transduction; Sp1 Transcription Factor; Tissue Inhibitor of Metalloproteinase-3 | 2009 |
Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia.
Topics: Analysis of Variance; Animals; Axons; Carbazoles; Cell Proliferation; Cells, Cultured; Central Nervous System; Culture Media, Conditioned; Cyclic AMP; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Ganglia, Spinal; Glial Fibrillary Acidic Protein; Indole Alkaloids; Myelin Sheath; Nerve Crush; Nerve Growth Factors; Neuroglia; Neurons; Quinazolines; Rats; RNA, Small Interfering; S100 Proteins; Transfection; Tyrphostins | 2009 |
Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Axons; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Cyclic AMP; ErbB Receptors; Female; Humans; Mice; Nerve Growth Factors; Nerve Regeneration; Neuroglia; Optic Nerve; Quinazolines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wistar; Receptor, trkA; Receptor, trkB; Receptor, trkC; Recombinant Fusion Proteins; Retinal Ganglion Cells; RNA, Small Interfering; Tyrphostins | 2009 |
Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation.
Topics: Afatinib; Amino Acid Substitution; Animals; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Cell Proliferation; Cluster Analysis; Drug Resistance, Neoplasm; ErbB Receptors; Furans; Humans; Lung Neoplasms; Molecular Structure; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinazolines; Receptor, ErbB-2; Signal Transduction | 2010 |
Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis.
Topics: Acetylcholine; Animals; Carbachol; Cell Differentiation; Epithelial Cells; Epithelium; ErbB Receptors; Ganglia, Parasympathetic; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Keratin-5; Male; Mice; Morphogenesis; Neurons; Organ Culture Techniques; Organogenesis; Prostate; Quinazolines; Receptor, Muscarinic M1; Regeneration; Signal Transduction; Stem Cells; Submandibular Gland | 2010 |
Irritant activation of epithelial cells is mediated via protease-dependent EGFR activation.
Topics: Cell Line; Early Growth Response Protein 1; Epithelial Cells; ErbB Receptors; Humans; Interleukin-8; Irritants; Keratinocytes; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Peptide Hydrolases; Quinazolines; Signal Transduction; Sodium Dodecyl Sulfate; Vascular Endothelial Growth Factor A | 2011 |
Epidermal growth factor receptor inhibition augments the expression of MHC class I and II genes.
Topics: Antibodies, Blocking; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cell Line; Cell Line, Tumor; Cetuximab; ErbB Receptors; Gene Expression Regulation; HCT116 Cells; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Hydroxamic Acids; Immunologic Factors; Interferon-gamma; Keratinocytes; Models, Biological; Nuclear Proteins; Protein Kinase Inhibitors; Quinazolines; Skin; Trans-Activators | 2011 |
Phenylbutyrate suppresses distinct skin reactions that are enhanced by blockade of epidermal growth factor receptor signaling.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Cells, Cultured; Chemokine CCL2; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; ErbB Receptors; Forkhead Transcription Factors; Histone Deacetylase Inhibitors; Immunosuppressive Agents; Injections, Intraperitoneal; Male; Mast Cells; Mice; Mice, Inbred BALB C; Phenylbutyrates; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Skin; Stem Cell Factor; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
A re-assessment of the effects of treatment with an epidermal growth factor receptor (EGFR) inhibitor on recovery of bladder and locomotor function following thoracic spinal cord injury in rats.
Topics: Animals; ErbB Receptors; Female; Infusion Pumps, Implantable; Motor Activity; Quinazolines; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; Thoracic Vertebrae; Treatment Outcome; Urinary Bladder | 2012 |
Comments on the re-assessment study by Sharp et al. of Erschbamer et al.
Topics: Animals; ErbB Receptors; Female; Motor Activity; Quinazolines; Recovery of Function; Spinal Cord Injuries; Urinary Bladder | 2012 |
The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Cell Proliferation; Chloroquine; ErbB Receptors; Genes, erbB; Humans; Lysosomes; Molecular Targeted Therapy; Nerve Sheath Neoplasms; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
Characterization of EGFR and ErbB2 expression in atopic dermatitis patients.
Topics: Adolescent; Adult; Cell Differentiation; Cell Line; Chemokine CCL26; Chemokines, CC; Dermatitis, Atopic; ErbB Receptors; Female; Humans; Inflammation Mediators; Interleukin-4; Keratinocytes; Male; Middle Aged; Quinazolines; Receptor, ErbB-2; Skin; Th2 Cells; Transcription, Genetic; Young Adult | 2012 |
Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury.
Topics: Animals; Cell Lineage; ErbB Receptors; Female; Mice; Neurogenesis; Neuroglia; Neurons; Quinazolines; Spinal Cord; Spinal Cord Injuries; Stem Cells | 2012 |
Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line; Cross-Linking Reagents; Disulfides; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Microscopy, Electron; Mutation; Phosphotransferases; Protein Conformation; Protein Kinase Inhibitors; Protein Multimerization; Protein Structure, Tertiary; Quinazolines | 2012 |
ErbB1 epidermal growth factor receptor is a valid target for reducing the effects of multiple inhibitors of axonal regeneration.
Topics: Animals; Axons; Blood-Brain Barrier; Calcium Signaling; Cerebellum; Chondroitin Sulfates; Cytoplasmic Granules; Fibrinogen; Genes, erbB-1; Mice; Mice, Knockout; Myelin Sheath; Nerve Regeneration; Phosphorylation; Poly I-C; Proteoglycans; Quinazolines; RNA; RNA, Double-Stranded; Sensory Receptor Cells; Toll-Like Receptor 3 | 2013 |
Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors.
Topics: Aniline Compounds; Cell Cycle Checkpoints; Cell Line, Tumor; Chemistry, Pharmaceutical; ErbB Receptors; Humans; Inhibitory Concentration 50; Molecular Structure; Phosphorylation; Quinazolines; Time Factors | 2013 |
Epidermal growth factor enhances androgen receptor‑mediated bladder cancer progression and invasion via potentiation of AR transactivation.
Topics: Androgens; Animals; Butylhydroxybutylnitrosamine; Carcinogenesis; Castration; Disease Models, Animal; Disease Progression; Epidermal Growth Factor; ErbB Receptors; Humans; Male; Mice; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Quinazolines; Receptors, Androgen; Signal Transduction; Transcriptional Activation; Urinary Bladder Neoplasms | 2013 |
Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Disease Models, Animal; ErbB Receptors; Exploratory Behavior; Female; Glial Fibrillary Acidic Protein; Gliosis; Kidney Diseases; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Recovery of Function; Regeneration; Spinal Cord Injuries | 2014 |
Activation of spinal neuregulin 1-ErbB2 signaling pathway in a rat model of cancer-induced bone pain.
Topics: Animals; Carcinoma 256, Walker; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Neoplasm Transplantation; Neoplasms; Neuregulin-1; Pain; Quinazolines; Rats; Receptor, ErbB-2; Signal Transduction; Tibia | 2014 |
NRG1-ErbB signalling promotes microglia activation contributing to incision-induced mechanical allodynia.
Topics: Animals; Foot Injuries; Hyperalgesia; Injections, Spinal; Macrophage Activation; Male; Mice; Mice, Inbred C57BL; Microglia; Neuregulin-1; Oncogene Proteins v-erbB; Pain, Postoperative; Physical Stimulation; Quinazolines; RNA, Small Interfering; Signal Transduction; Spinal Cord; Suppression, Genetic; Up-Regulation | 2015 |
Effects of ROCK inhibitor Y27632 and EGFR inhibitor PD168393 on human neural precursors co-cultured with rat auditory brainstem explant.
Topics: Amides; Animals; Brain Stem; Cell Movement; Cell Survival; Cochlear Nucleus; Coculture Techniques; Enzyme Inhibitors; ErbB Receptors; Humans; Neural Stem Cells; Neuroglia; Pyridines; Quinazolines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Tissue Culture Techniques | 2015 |
Inhibition of progression of PanIN through antagonizing EGFR.
Topics: Animals; Antineoplastic Agents; Carcinoma in Situ; Disease Progression; Drug Screening Assays, Antitumor; ErbB Receptors; Male; Mice, Transgenic; Pancreas; Pancreatic Neoplasms; Quinazolines; Tyrphostins | 2015 |
Modulation of influenza vaccine immune responses using an epidermal growth factor receptor kinase inhibitor.
Topics: Administration, Topical; Animals; Chemokine CCL2; Cytokines; ErbB Receptors; Female; Immunity, Humoral; Influenza Vaccines; Lymph Nodes; Mice, Inbred BALB C; Orthomyxoviridae Infections; Protein Kinase Inhibitors; Quinazolines; Skin; Vaccination | 2015 |
The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia.
Topics: Animals; Endotoxemia; ErbB Receptors; Erlotinib Hydrochloride; Heart Failure; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phosphorylation; Quinazolines; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
Inhibition of Epidermal Growth Factor Receptor Improves Myelination and Attenuates Tissue Damage of Spinal Cord Injury.
Topics: Animals; Astrocytes; Axons; Disease Models, Animal; ErbB Receptors; Female; Mice; Myelin Sheath; Neuroglia; Oligodendroglia; Quinazolines; Recovery of Function; Spinal Cord; Spinal Cord Injuries | 2016 |
Epidermal growth factor receptor inhibitors trigger a type I interferon response in human skin.
Topics: Adult; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cetuximab; Chemokines; ErbB Receptors; Female; Gene Expression Regulation; Humans; Interferon Type I; Keratinocytes; Male; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Skin; Tumor Necrosis Factor-alpha; Young Adult | 2016 |
Studying the Conformation of a Receptor Tyrosine Kinase in Solution by Inhibitor-Based Spin Labeling.
Topics: Electron Spin Resonance Spectroscopy; ErbB Receptors; Humans; Models, Molecular; Molecular Structure; Protein Conformation; Protein Kinase Inhibitors; Quinazolines; Solutions; Spin Labels; Structure-Activity Relationship | 2017 |
Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer.
Topics: Antineoplastic Agents; Apoptosis; Caco-2 Cells; Cell Line, Tumor; Colonic Neoplasms; ErbB Receptors; Gefitinib; Genes, src; HCT116 Cells; HT29 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Quinazolines; Signal Transduction; src-Family Kinases | 2018 |
Neuregulin-1-ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide-induced cystitis.
Topics: Animals; Cystitis; Female; Hyperalgesia; Injections, Spinal; Macrophage Activation; Microglia; Neuregulin-1; Oncogene Proteins v-erbB; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation.
Topics: Dipeptides; ErbB Receptors; HEK293 Cells; Humans; Hydroxamic Acids; Lipopolysaccharides; Macrophages; Phosphorylation; Quinazolines; rab5 GTP-Binding Proteins; Signal Transduction; Surface Properties; Toll-Like Receptor 4 | 2020 |