Compounds > quinazolines
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quinazolines and pd 98059

quinazolines has been researched along with pd 98059 in 91 studies

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (2.20)18.2507
2000's58 (63.74)29.6817
2010's31 (34.07)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allal, C; Asslan, R; Favre, G; Le Gaillard, F; Pradines, A; Pratx, C1
Polk, DB; Tong, W1
Guo, C; Luttrell, LM; Price, DT1
Abe, K; Saito, H1
Barrett, KE; Calandrella, SO; Keely, SJ1
Bonner, JC; Wang, YZ1
Belt, A; Fisher, G; Voorhees, J; Wan, Y; Wang, Z1
Adrian, TE; Cluck, MW; Knezetic, JA; Larsson, J; Lovas, S; Murphy, LO; Murphy, RF; Otvös, F; Permert, J; Schally, AV1
Huggett, TM; Jost, M; Kari, C; Rodeck, U1
Devlin, RB; Ghio, AJ; Samet, JM; Wu, W1
Nishinaka, T; Yabe-Nishimura, C1
Kodama, S; Suzuki, K; Watanabe, M1
Pouysségur, J; Viñals, F1
Avkiran, M; Hearse, DJ; Snabaitis, AK1
Ananthan, S; Carroll, FI; Dersch, CM; Rothman, RB1
Graves, LM; Jaspers, I; Samet, JM; Wu, W; Zhang, W1
Carter, RW; Kanagy, NL1
Huang, XL; Lawrence, M; Madara, P; Nanavaty, UB; Pawliczak, R; Shelhamer, JH1
Chatziantoniou, C; Coffman, T; Dussaule, JC; Flamant, M; Henrion, D; Placier, S; Tharaux, PL1
Alonso, A; Dürst, M; Leykauf, K1
Barrow, D; Gee, JM; Harper, ME; Hutcheson, IR; Jones, HE; Knowlden, JM; Madden, T; Nicholson, RI; Wakeling, AE1
Chung, T; Dent, P; Hagan, MP; Hinman, D; McKinstry, R; Yacoub, A1
Li, J; Majumdar, AP; Xiao, ZQ1
Gui, Y; Zheng, XL1
Cheng, K; Raufman, JP; Zimniak, P1
Brake, DK; Deszo, EL; Freund, GG; Kelley, KW1
Barrett, KE; Bertelsen, LS; Keely, SJ1
Slomiany, A; Slomiany, BL1
Bowling, GH; Khan, SA; Millena, AC; Reddy, SC1
Chalothorn, D; Faber, JE; Jackson, LF; Lee, DC; Zhang, H1
Bagnato, A; Di Castro, V; Elia, G; Natali, PG; Rosanò, L; Spinella, F1
Boulesteix, C; Gall, L; Germain, G; Ruffini, S1
Bao, Y; Ding, YB; Li, XY; Shi, RH; Tong, JD; Wang, XH; Wu, J; Xiao, WM; Yan, ZG; Yang, JG; Zhang, GX1
El Shewy, H; Gesty-Palmer, D; Kohout, TA; Luttrell, LM1
Finlay, D; Furlong, F; Martin, F1
Higashiyama, S; Itoh, M; Joh, T; Kataoka, H; Nakao, H; Ohhara, H; Ohshima, T; Sasaki, M; Tanida, S; Watanabe, K1
Kim, SY; Kim, YK; Kwon, CH; Lee, JS1
Fishman, DA; Kang, S; Luo, R; Meng, Y; Smicun, Y1
Campiglio, M; Carotenuto, A; De Luca, A; Maiello, MR; Mancino, M; Menard, S; Napolitano, M; Normanno, N; Viglietto, G1
Ikejima, T; Onodera, S; Tashiro, S; Wang, C; Wang, MW1
Belldegrun, A; Figlin, R; Iwata, KK; Jin, Y; Lieberman, R; Pantuck, A; Rao, J; Zhang, ZF1
Collins, S; Cyr, M; Daniel, KW; Kumar, N; Medvedev, AV; Moukdar, F; Robidoux, J1
Carmona-Cuenca, I; Del Castillo, G; Fabregat, I; Fernández, M; Murillo, MM; Ortiz, C; Roncero, C; Sánchez, A1
Kimura, M; Ogihara, M; Okamoto, H1
Ascoli, M; Shiraishi, K1
Abel, J; Cline, JE; Fritsche, E; Moors, M1
Hitomi, T; Kawanaka, M; Koyama, M; Matsuzaki, Y; Sakai, T; Yogosawa, S1
Chao, HH; Chen, YL; Cheng, TH; Chiu, WT; Hong, HJ; Lin, JW; Liu, JC; Shyu, KG; Wu, CH1
Kawashima, I; Nishibori, M; Richards, JS; Shimada, M; Yamashita, Y; Yanai, Y1
Andresen, BT; Escano, CS; Gutweiler, AA; Keever, LB1
Horn, F; Klappenberger, S; Lattrich, C; Ortmann, O; Pfeiler, G; Treeck, O1
Bassa, BV; Ganji, SH; Kamanna, VS; Noh, JW; Roh, DD; Shin, MK1
Avissar, NE; Sax, HC; Toia, L1
Choi, JW; Choi, MS; Go, HS; Jeon, SJ; Kim, SD; Kim, WK; Kim, YE; Ko, KH; Lee, WJ; Park, GH; Shin, CY; Shin, SM1
Choi, WS; Han, JW; Jeong, KJ; Kang, JK; Kim, YK; Lee, HY; Lee, KB; Park, CG; Park, SY; Seo, JH1
Batra, SK; Davis, JS; Davis, TL; Hauke, R; Lin, FF; Lin, MF; Schutte, R; Zelivianski, S; Zhang, L1
Baer, PC; Geiger, H; Schubert, R; Zielen, S1
Chen, CL; Lo, HM; Tsai, YJ; Wu, PH; Wu, WB1
Kohsaka, S; Maeda, S; Nakajima, K; Tohyama, Y1
Dooley, R; Harvey, BJ; McEneaney, V; Thomas, W1
Donnellan, F; Geoghegan, P; Harvey, BJ; Keating, N; Keely, SJ; Murray, FE1
Mekada, E; Miyamoto, S; Mizushima, H; Wang, X1
Hao, YY; Iwamori, M; Li, FF; Lin, B; Liu, DW; Liu, JJ; Qi, Y; Zhang, SL; Zhu, LC1
Bollinger, N; Joslin, EJ; Lauffenburger, DA; Opresko, LK; Shankaran, H; Wiley, HS1
Fujita, T; Kajiya, M; Kawaguchi, H; Komatsuzawa, H; Kurihara, H; Mizuno, N; Ouhara, K; Shiba, H; Takeda, K; Uchida, Y1
Arnoletti, JP; Frolov, A; Heslin, MJ; Howard, JH; Kossenkov, AV; Kulesza, P; Liles, JS; Tzeng, CW1
Chabot, JG; Ma, W; Quirion, R; Wang, Z1
Jean-Claude, B; Larroque-Lombard, AL; Qiyu, Q; Todorova, M1
Kolosov, VP; Li, N; Li, Q; Perelman, JM; Zhou, XD1
Arnold, W; Beck, C; Boulesteix, AL; Knopf, A; Margraf, J; Pickhard, AC; Pigorsch, S; Piontek, G; Reiter, R; Scherer, EQ; Schlegel, J; Stark, T1
Chen, SC; Chiou, SJ; Chuang, LY; Guh, JY; Hwang, CC; Ko, YM; Lin, TD1
Aida, Y; Honda, K; Maeno, M; Makimura, M; Matsumura, H; Nakayama, G; Shimizu, O; Suzuki, N; Takeichi, O; Tanigawa, S1
Oganesian, A; Parks, WC; Schwinn, DA; Yarov-Yarovoy, V1
Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ1
Chang, CM; Chang, WC; Chuang, HY; Hou, MF; Lee, YC; Lin, YC; Tsai, YT; Wang, JY; Wei, PL; Wong, JH1
Fujii, H; Izawa, S; Kiessling, R; Kono, K; Kua, LF; Mimura, K; Mueller, A; Seliger, B; Shiraishi, K; So, J; Yong, WP1
Byagowi, S; Darabi, M; Fayezi, S; Mirshahvaladi, S; Sahmani, M1
Eicheler, W; Holler, M; Meier, F; Minjgee, M; Rodemann, HP; Saki, M; Toulany, M1
Grazide, MH; Josse, G; Larroque-Cardoso, P; Mucher, E; Nadal-Wolbold, F; Nègre-Salvayre, A; Salvayre, R; Schmitt, AM; Zarkovic, K1
Crews, LA; Gonzales, T; Kouznetsova, VL; Masliah, E; Overk, CR; Patrick, C; Paulino, A; Price, D; Rockenstein, E; Stocking, E; Tsigelny, IF; Wrasidlo, W1
Aithagani, SK; Bhushan, S; Guru, SK; Kumar, A; Kumar, S; Malik, F; Pathania, AS; Sharma, PR; Singh, PP; Vishwakarma, RA1
Kimura, M; Moteki, H; Ogihara, M1
Han, S; Jung, Y; Kang, C; Kim, E; Kim, W; Kwon, T; Lee, S; Yang, HJ; Youn, B; Youn, H1
Garófalo, A; Giai, C; Gómez, MI; Gonzalez, CD; Ledo, C1
Cheng, XD; Feng, L; Gu, JF; Jia, XB; Yuan, JR1
Guo, T; Li, L; Li, RJ; Pan, JH; Peng, YZ; Wang, Y; Yang, P; Zheng, K1
Jiang, J; Tang, X; Wang, Y; Yao, Y; Zhou, J1
Banerji, A; Bose, C; Kumar, GB; Nair, BG; Omanakuttan, A; Pandurangan, N1
Han, G; Heaps, CL; Stallone, JN; Yu, X1
Almeida, VH; Berzoti-Coelho, MG; Borges, CS; Cacemiro, MDC; Castro, FA; Ferreira, AF; Figueiredo-Pontes, LL; Gomes, FG; Monteiro, RQ; Nunes, NS; Simões, BP1
Chang, HN; Chueh, HY; Pang, JS; Yeh, YC1

Other Studies

91 other study(ies) available for quinazolines and pd 98059

ArticleYear
Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells.
    Biochemical and biophysical research communications, 1999, Jul-14, Volume: 260, Issue:3

    Topics: Adenocarcinoma; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

1999
Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Animals; Cell Division; Cell Line, Transformed; Chemotaxis; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Matrix; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Genistein; Growth Substances; Hepatocyte Growth Factor; Insulin-Like Growth Factor I; Intestines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Quinazolines; Transforming Growth Factor beta; Type C Phospholipases; Tyrphostins

1999
Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines.
    The Journal of urology, 2000, Volume: 163, Issue:3

    Topics: Cell Division; Dihydrotestosterone; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2000
The mitogen-activated protein kinase cascade mediates neurotrophic effect of epidermal growth factor in cultured rat hippocampal neurons.
    Neuroscience letters, 2000, Mar-17, Volume: 282, Issue:1-2

    Topics: Animals; Blotting, Western; Butadienes; Cell Survival; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hippocampus; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Tyrphostins

2000
Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src).
    The Journal of biological chemistry, 2000, Apr-28, Volume: 275, Issue:17

    Topics: Calcium; Carbachol; Cell Line; Chlorides; Colon; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; Fluphenazine; Focal Adhesion Kinase 2; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Signal Transduction; Thapsigargin; Time Factors; Transcriptional Activation; Tyrphostins

2000
Mechanism of extracellular signal-regulated kinase (ERK)-1 and ERK-2 activation by vanadium pentoxide in rat pulmonary myofibroblasts.
    American journal of respiratory cell and molecular biology, 2000, Volume: 22, Issue:5

    Topics: Acetylcysteine; Animals; Asthma; Bronchitis; Carbon; Coal Ash; Colforsin; Enzyme Activation; ErbB Receptors; Fibroblasts; Flavonoids; Intracellular Signaling Peptides and Proteins; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Particulate Matter; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Quinazolines; Rats; Titanium; Tyrphostins; Vanadium Compounds

2000
Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.
    International journal of molecular medicine, 2001, Volume: 7, Issue:3

    Topics: Blotting, Western; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Interleukin-1; Keratinocytes; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Models, Biological; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinazolines; Time Factors; Tyrphostins

2001
Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.
    British journal of cancer, 2001, Apr-06, Volume: 84, Issue:7

    Topics: Cell Division; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gastrin-Releasing Peptide; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Quinazolines; Substrate Specificity; Transcription Factor AP-1; Tumor Cells, Cultured; Tyrphostins

2001
Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.
    Molecular biology of the cell, 2001, Volume: 12, Issue:5

    Topics: bcl-X Protein; Calcium-Calmodulin-Dependent Protein Kinases; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Flavonoids; Humans; In Situ Nick-End Labeling; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tyrphostins

2001
Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 281, Issue:2

    Topics: Air Pollutants, Occupational; Bronchi; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Interleukin-8; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Metallurgy; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinazolines; Respiratory Mucosa; RNA, Messenger; Signal Transduction; Tyrphostins; Utah

2001
EGF receptor-ERK pathway is the major signaling pathway that mediates upregulation of aldose reductase expression under oxidative stress.
    Free radical biology & medicine, 2001, Jul-15, Volume: 31, Issue:2

    Topics: Aldehyde Reductase; Animals; Cell Line; Cell Survival; Diabetes Complications; Diabetes Mellitus; ErbB Receptors; Flavonoids; Free Radical Scavengers; Humans; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Oxidative Stress; Phthalazines; Protein Kinases; Quinazolines; Rats; RNA, Messenger; Signal Transduction; Tyrphostins; Up-Regulation

2001
Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells.
    Cancer research, 2001, Jul-15, Volume: 61, Issue:14

    Topics: Cell Division; Cell Line; Cell Survival; Diploidy; DNA-Binding Proteins; DNA, Antisense; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gene Expression; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins; Quinazolines; Transcription Factors; Tumor Suppressor Protein p53; Tyrphostins

2001
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.
    Molecular and cellular biology, 2001, Volume: 21, Issue:21

    Topics: Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Chromones; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Wortmannin

2001
Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.
    Cardiovascular research, 2002, Feb-01, Volume: 53, Issue:2

    Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Genistein; Hydrogen Peroxide; Imidazoles; Immunoblotting; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Rats; Rats, Wistar; Sarcolemma; Signal Transduction; Sodium-Hydrogen Exchangers; src-Family Kinases; Tyrphostins

2002
Studies of the biogenic amine transporters. VIII: identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding.
    Synapse (New York, N.Y.), 2002, Mar-15, Volume: 43, Issue:4

    Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Male; MAP Kinase Signaling System; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Synaptosomes

2002
Role of Ras in metal-induced EGF receptor signaling and NF-kappaB activation in human airway epithelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:5

    Topics: Arsenic; Bronchi; Cell Line, Transformed; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; I-kappa B Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Metals; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Quinazolines; Respiratory Mucosa; Vanadium; Zinc

2002
Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Calcium; Enzyme Inhibitors; Flavonoids; Hypertension; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tyrphostins

2002
Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.
    American journal of respiratory cell and molecular biology, 2002, Volume: 27, Issue:6

    Topics: Antineoplastic Agents; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Ionophores; Lung; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pyridines; Quinazolines; ras Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins

2002
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:2

    Topics: Animals; Aorta; Blood Pressure; Collagen Type I; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibrosis; Flavonoids; In Vitro Techniques; Luciferases; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Quinazolines; Tyrphostins; Vasoconstriction

2003
Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells.
    Cell and tissue research, 2003, Volume: 311, Issue:1

    Topics: Animals; Anisomycin; Antibody Specificity; Cell Membrane; Cells, Cultured; Connexin 43; Cytoplasm; Diuretics, Osmotic; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Fluorescent Antibody Technique; Liver; Microscopy, Confocal; Osmotic Pressure; Phosphorylation; Protein Synthesis Inhibitors; Quinazolines; Rabbits; Rats; Sorbitol; Tyrphostins

2003
Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells.
    Endocrinology, 2003, Volume: 144, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cell Division; Dimerization; Drug Resistance, Neoplasm; ErbB Receptors; Flavonoids; Gefitinib; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Receptor, ErbB-2; RNA, Messenger; Tamoxifen; Transforming Growth Factor alpha; Trastuzumab; Tumor Cells, Cultured

2003
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling.
    Radiation research, 2003, Volume: 159, Issue:4

    Topics: Adenocarcinoma; Autocrine Communication; Cobalt Radioisotopes; DNA Damage; DNA Repair; DNA-Binding Proteins; Endonucleases; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Prostatic Neoplasms; Protein Biosynthesis; Proteins; Quinazolines; Tumor Cells, Cultured; Tyrphostins; X-ray Repair Cross Complementing Protein 1

2003
Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:2

    Topics: Aging; Animals; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Gastric Mucosa; Male; Mitogen-Activated Protein Kinase Kinases; Pyrimidines; Quinazolines; Rats; Rats, Inbred F344; Signal Transduction; src-Family Kinases; Transcription Factor AP-1; Transforming Growth Factor alpha

2003
Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway.
    The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52

    Topics: Animals; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Cycle Proteins; Cell Division; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Male; MAP Kinase Signaling System; Microscopy, Confocal; Muscle, Smooth, Vascular; Phenotype; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; S Phase; Time Factors; Tumor Suppressor Proteins; Tyrphostins

2003
Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells.
    Cancer research, 2003, Oct-15, Volume: 63, Issue:20

    Topics: Acetylcholine; Animals; Atropine; Cell Division; CHO Cells; Cholinergic Agonists; Colonic Neoplasms; Cricetinae; Drug Interactions; Egtazic Acid; ErbB Receptors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Ribosomal Protein S6 Kinases, 90-kDa; Transcriptional Activation; Tyrphostins

2003
IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta.
    Cellular signalling, 2004, Volume: 16, Issue:2

    Topics: Acetophenones; Antigens, CD; B7-2 Antigen; Benzopyrans; CD11b Antigen; Cell Differentiation; Cell Nucleus; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-4; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Monocytes; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Quinazolines

2004
Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Androstadienes; Blotting, Western; Cell Line; Chlorides; Chlorine; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; GTP-Binding Protein alpha Subunits, Gs; Humans; Ions; Isoquinolines; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Quinazolines; Sulfonamides; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin

2004
Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.
    Biochemical and biophysical research communications, 2004, May-21, Volume: 318, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Androstadienes; Animals; Bucladesine; Choline; Colforsin; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Isoproterenol; Phosphoinositide-3 Kinase Inhibitors; Phospholipids; Pyrimidines; Quinazolines; Rats; Receptors, Adrenergic, beta; Saliva; src-Family Kinases; Sublingual Gland; Transcriptional Activation; Wortmannin

2004
Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha.
    Molecular and cellular endocrinology, 2004, Sep-30, Volume: 224, Issue:1-2

    Topics: Androgens; Animals; Autocrine Communication; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gene Expression Regulation; Isoquinolines; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinases; Phosphoproteins; Quinazolines; Rats; RNA, Messenger; Steroids; Sulfonamides; Transforming Growth Factor alpha; Tyrphostins

2004
Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.
    Circulation research, 2004, Nov-12, Volume: 95, Issue:10

    Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anthracenes; Aorta, Thoracic; Bacterial Proteins; Benzopyrans; Butadienes; Catheterization; Cell Division; Dipeptides; ErbB Receptors; Flavonoids; Glycine; Hydroxamic Acids; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Organ Culture Techniques; Phenylephrine; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Thrombin; Tyrphostins

2004
Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.
    Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Induction; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor, Endothelin A; Signal Transduction; Transcriptional Activation; Tyrphostins

2004
EGF-induced EGF-receptor and MAP kinase phosphorylation in goat cumulus cells during in vitro maturation.
    Molecular reproduction and development, 2005, Volume: 71, Issue:4

    Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Goats; Immunoassay; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Ovarian Follicle; Phosphorylation; Quinazolines; Time Factors; Tyrphostins

2005
PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system.
    Experimental oncology, 2005, Volume: 27, Issue:2

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Oxytocics; Phosphorylation; Quinazolines; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Transcriptional Activation; Tumor Cells, Cultured; Tyrphostins; Up-Regulation; Vascular Endothelial Growth Factor A

2005
beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
    The Journal of biological chemistry, 2005, Sep-16, Volume: 280, Issue:37

    Topics: Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epitopes; ErbB Receptors; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Lysophospholipids; Mice; Mice, Knockout; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Phosphorylation; Quinazolines; ras Proteins; RNA; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrphostins

2005
PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis.
    Biochemical and biophysical research communications, 2005, Nov-04, Volume: 336, Issue:4

    Topics: Animals; Apoptosis; Cell Adhesion; Cell Survival; Cells, Cultured; Epithelial Cells; ErbB Receptors; Female; Flavonoids; Insulin; Laminin; Mammary Glands, Animal; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinazolines; Tyrphostins; Vanadates

2005
Helicobacter pylori-stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase (ADAM) activation.
    Digestive diseases and sciences, 2005, Volume: 50, Issue:11

    Topics: ADAM Proteins; Cell Line, Tumor; Cell Proliferation; DNA; Enzyme Activation; ErbB Receptors; Flavonoids; Glycine; Helicobacter pylori; Humans; Hydroxamic Acids; Interleukin-8; MAP Kinase Kinase 1; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Transcriptional Activation; Tyrphostins

2005
EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells.
    Archives of toxicology, 2006, Volume: 80, Issue:6

    Topics: Animals; Apoptosis; Butadienes; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hydrogen Peroxide; Kidney Tubules, Proximal; MAP Kinase Kinase 1; Membrane Potentials; Mitochondrial Membranes; Nitriles; Opossums; Oxidants; Pyrimidines; Quinazolines; Transfection; Tyrphostins

2006
Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation.
    FEBS letters, 2006, Jan-23, Volume: 580, Issue:2

    Topics: Animals; Antigen Presentation; Antigens, Surface; Apoptosis; Aspirin; Cell Line, Tumor; Cell Membrane; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fas Ligand Protein; Female; Flavonoids; Humans; Lymphocyte Activation; Lymphocytes; Lysophospholipids; Membrane Glycoproteins; Nitrobenzenes; Ovarian Neoplasms; Quinazolines; Signal Transduction; Sulfonamides; Tumor Necrosis Factors; Tyrphostins

2006
The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib.
    Journal of cellular physiology, 2006, Volume: 207, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Female; Flavonoids; Gefitinib; Humans; Inhibitory Concentration 50; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Transfection

2006
[Effect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamine].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:11

    Topics: Apoptosis; Cell Line, Tumor; Evodia; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Melanoma; Plant Extracts; Plants, Medicinal; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Staurosporine

2005
Effect of an epidermal growth factor receptor tyrosine kinase inhibitor on actin remodeling in an in vitro bladder cancer carcinogenesis model.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:7

    Topics: Actins; Anticarcinogenic Agents; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; ErbB Receptors; Erlotinib Hydrochloride; Flavonoids; Humans; Inhibitory Concentration 50; Mitogen-Activated Protein Kinase Kinases; Protein Kinase Inhibitors; Quinazolines; Urinary Bladder Neoplasms

2006
Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.
    The Journal of biological chemistry, 2006, Dec-08, Volume: 281, Issue:49

    Topics: 3T3-L1 Cells; Adipocytes; Adrenergic beta-3 Receptor Agonists; Animals; Cyclic AMP-Dependent Protein Kinases; Dioxoles; Enzyme Activation; ErbB Receptors; Estradiol; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Isoquinolines; Lipolysis; Mice; Quinazolines; Receptors, Adrenergic, beta-3; RNA, Small Interfering; src-Family Kinases; Sulfonamides; Tyrphostins

2006
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.
    The Biochemical journal, 2007, Jul-15, Volume: 405, Issue:2

    Topics: Acetophenones; Animals; Anthracenes; Benzamides; Chromones; Dioxoles; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heparin-binding EGF-like Growth Factor; Hepatocytes; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Morpholines; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Onium Compounds; Peptides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Transforming Growth Factor beta; Tyrphostins; Up-Regulation

2007
Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.
    Journal of pharmacological sciences, 2007, Volume: 103, Issue:4

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Hepatocytes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Biological; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Sphingosine; Tyrphostins; Wortmannin

2007
Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.
    Endocrinology, 2007, Volume: 148, Issue:7

    Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Dipeptides; Epidermal Growth Factor; Flavonoids; Immunohistochemistry; Inositol Phosphates; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyrazoles; Pyrimidines; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Steroids; Tyrphostins

2007
ERK-dependent and -independent pathways trigger human neural progenitor cell migration.
    Toxicology and applied pharmacology, 2007, May-15, Volume: 221, Issue:1

    Topics: Astrocytes; Blotting, Western; Cell Differentiation; Cell Movement; Cell Survival; Cells, Cultured; Flavonoids; Humans; Indoles; Maleimides; Methylmercury Compounds; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Protein Kinase C; Pyrimidines; Quinazolines; Signal Transduction; Spheroids, Cellular; src-Family Kinases; Stem Cells; Sulfonamides; Tetradecanoylphorbol Acetate; Tyrphostins

2007
ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:5

    Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p15; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G1 Phase; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Models, Biological; Phosphorylation; Quinazolines; Signal Transduction

2007
Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Animals; Aorta, Thoracic; Blotting, Northern; Blotting, Western; Butadienes; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Endothelin-1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Leptin; Male; Metalloendopeptidases; Myocytes, Smooth Muscle; Nitriles; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Signal Transduction; Transcriptional Activation; Tyrosine; Tyrphostins

2007
Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor.
    Endocrinology, 2007, Volume: 148, Issue:12

    Topics: ADAM Proteins; ADAM17 Protein; Amphiregulin; Animals; Blotting, Western; Cells, Cultured; Cumulus Cells; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Flavonoids; Follicle Stimulating Hormone; Gene Expression; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oocytes; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Swine; Transfection; Tyrphostins

2007
Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Kidney; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Inbred WKY; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Tyrphostins; Vasoconstrictor Agents

2008
Apoptotic effects of signal transduction inhibitors on human tumor cells with different PTEN expression.
    Oncology reports, 2007, Volume: 18, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Estrogen Antagonists; Flavonoids; Gefitinib; Humans; Mitogen-Activated Protein Kinases; PTEN Phosphohydrolase; Quinazolines; Signal Transduction; Tamoxifen

2007
Lysophosphatidylcholine stimulates EGF receptor activation and mesangial cell proliferation: regulatory role of Src and PKC.
    Biochimica et biophysica acta, 2007, Volume: 1771, Issue:11

    Topics: Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Indoles; Lysophosphatidylcholines; Maleimides; MAP Kinase Signaling System; Mesangial Cells; Protein Kinase C; Quinazolines; src-Family Kinases; Tyrphostins

2007
In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:8

    Topics: Amino Acid Transport System ASC; Androstadienes; Blotting, Western; Caco-2 Cells; Cell Membrane; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamine; Humans; Minor Histocompatibility Antigens; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; rho GTP-Binding Proteins; RNA Interference; Signal Transduction; Sodium; Time Factors; Tyrphostins; Up-Regulation; Wortmannin

2008
Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes.
    Brain research bulletin, 2008, Jul-01, Volume: 76, Issue:4

    Topics: Animals; Astrocytes; Cells, Cultured; Encephalitis; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Thrombin

2008
Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.
    Experimental & molecular medicine, 2008, Dec-31, Volume: 40, Issue:6

    Topics: Butadienes; Cell Line, Tumor; Cell Movement; CSK Tyrosine-Protein Kinase; Cyclooxygenase 2; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Nitriles; Ovarian Neoplasms; Pertussis Toxin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrimidines; Quinazolines; Receptors, Lysophosphatidic Acid; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins

2008
Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment.
    Cancer letters, 2009, Nov-18, Volume: 285, Issue:1

    Topics: Androgens; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gemcitabine; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Receptor, ErbB-2; Time Factors; Tyrphostins

2009
Simultaneous detection of ERK-, p38-, and JNK-MAPK phosphorylation in human adipose-derived stem cells using the Cytometric Bead Array technology.
    Journal of immunological methods, 2009, Oct-31, Volume: 350, Issue:1-2

    Topics: Adipose Tissue; Adult; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Flow Cytometry; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mesenchymal Stem Cells; Microspheres; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Tyrphostins

2009
Thrombin induces cyclooxygenase-2 expression and prostaglandin E2 release via PAR1 activation and ERK1/2- and p38 MAPK-dependent pathway in murine macrophages.
    Journal of cellular biochemistry, 2009, Dec-01, Volume: 108, Issue:5

    Topics: Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; Flavonoids; Imidazoles; Macrophages, Peritoneal; Mice; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Thrombin; Thromboxane A2

2009
Characteristic response of astrocytes to plasminogen/plasmin to upregulate transforming growth factor beta 3 (TGFbeta3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream phosphatidylinositol 3-kinase (PI3K)-Akt/PKB si
    Brain research, 2009, Dec-11, Volume: 1305

    Topics: Analysis of Variance; Animals; Astrocytes; Blotting, Western; Cells, Cultured; Chromones; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolysin; Fibrinolytic Agents; Fibroblast Growth Factors; Flavonoids; Immunohistochemistry; Microglia; Morpholines; Nerve Growth Factors; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasminogen; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta3

2009
Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.
    The Journal of steroid biochemistry and molecular biology, 2010, Volume: 118, Issue:1-2

    Topics: Acetophenones; Active Transport, Cell Nucleus; Aldosterone; Animals; Benzopyrans; Cell Line; Cell Proliferation; Cytoplasm; Enzyme Activation; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Kidney Cortex; Kidney Tubules, Collecting; Mice; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Phosphorylation; Protein Binding; Protein Kinase C-delta; Protein Kinase Inhibitors; Quinazolines; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; TRPP Cation Channels; Tyrphostins

2010
JNK mitogen-activated protein kinase limits calcium-dependent chloride secretion across colonic epithelial cells.
    American journal of physiology. Gastrointestinal and liver physiology, 2010, Volume: 298, Issue:1

    Topics: Amino Acids, Cyclic; Anthracenes; Calcium; Carbachol; Cell Line; Cell Polarity; Chlorides; Cholinergic Agonists; Colon; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Phosphorylation; Potassium; Quinazolines; Thapsigargin; Tyrphostins

2010
Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.
    Journal of cell science, 2009, Dec-01, Volume: 122, Issue:Pt 23

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Chromones; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gefitinib; Heparin-binding EGF-like Growth Factor; Humans; Integrins; Intercellular Signaling Peptides and Proteins; Mice; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Signal Transduction

2009
Lewis(y) antigen stimulates the growth of ovarian cancer cells via regulation of the epidermal growth factor receptor pathway.
    Oncology reports, 2010, Volume: 23, Issue:3

    Topics: Cell Line, Tumor; Cell Proliferation; Chromones; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Fucosyltransferases; Gefitinib; Humans; Lewis Blood Group Antigens; Morpholines; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines

2010
Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.
    Molecular bioSystems, 2010, Volume: 6, Issue:7

    Topics: Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gefitinib; Gene Regulatory Networks; Hepatocyte Growth Factor; Humans; Imidazoles; Ligands; Lysophospholipids; Mammary Glands, Human; Phosphorylation; Pyridines; Quinazolines; Signal Transduction; Transcriptional Activation; Transforming Growth Factor alpha

2010
The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics.
    Journal of endodontics, 2010, Volume: 36, Issue:6

    Topics: Adenosine Triphosphate; Anthracenes; Antimicrobial Cationic Peptides; Calcium-Calmodulin-Dependent Protein Kinases; Cathelicidins; Cell Movement; Cells, Cultured; Dental Pulp; Endodontics; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Protein Tyrosine Phosphatases; Purinergic P2 Receptor Agonists; Quinazolines; Receptors, Cell Surface; Receptors, Purinergic P2X; Regenerative Medicine; Tissue Engineering; Tyrphostins

2010
ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma.
    Cancer biology & therapy, 2010, Sep-15, Volume: 10, Issue:6

    Topics: Adenocarcinoma; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; ErbB Receptors; Erlotinib Hydrochloride; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Morpholines; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-3; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays

2010
Calcitonin gene-related peptide as a regulator of neuronal CaMKII-CREB, microglial p38-NFκB and astroglial ERK-Stat1/3 cascades mediating the development of tolerance to morphine-induced analgesia.
    Pain, 2010, Volume: 151, Issue:1

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Calcitonin Receptor-Like Protein; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Male; Morphine; Nerve Tissue Proteins; NF-kappaB-Inducing Kinase; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Physical Stimulation; Piperazines; Protein Serine-Threonine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor Activity-Modifying Protein 1; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; STAT3 Transcription Factor

2010
Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK.
    Chemical biology & drug design, 2011, Volume: 77, Issue:5

    Topics: Acetylation; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; DNA; DNA Damage; ErbB Receptors; Female; Flavonoids; Gene Expression; Humans; Male; Mass Spectrometry; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Neoplasms; NIH 3T3 Cells; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Triazenes

2011
Chronic mechanical stress induces mucin 5AC expression in human bronchial epithelial cells through ERK dependent pathways.
    Molecular biology reports, 2012, Volume: 39, Issue:2

    Topics: Analysis of Variance; Blotting, Western; Bronchi; Bronchoconstriction; Cells, Cultured; DNA Primers; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Flavonoids; Focal Adhesion Kinase 1; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Signaling System; Mucin 5AC; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Stress, Physiological; Tyrphostins

2012
Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.
    BMC cancer, 2011, Sep-06, Volume: 11

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Head and Neck Neoplasms; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Quinazolines; Signal Transduction; Sirolimus; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Tyrphostins

2011
Gefitinib attenuates transforming growth factor-β1-activated mitogen-activated protein kinases and mitogenesis in NRK-49F cells.
    Translational research : the journal of laboratory and clinical medicine, 2011, Volume: 158, Issue:4

    Topics: Animals; Benzamides; Cell Line; Collagen; Cyclin D1; Dioxoles; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gefitinib; Imidazoles; Kidney; MAP Kinase Signaling System; Mice; Mitosis; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Rats; Receptors, Transforming Growth Factor beta; Smad Proteins; Transforming Growth Factor beta1; Translational Research, Biomedical

2011
IL-6 and soluble IL-6 receptor stimulate the production of MMPs and their inhibitors via JAK-STAT and ERK-MAPK signalling in human chondrocytes.
    Cell biology international, 2012, Apr-01, Volume: 36, Issue:4

    Topics: Cartilage; Chondrocytes; Flavonoids; Gene Expression Regulation; Humans; Interleukin-6; Janus Kinase 3; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Plasminogen Activator Inhibitor 1; Primary Cell Culture; Protein Kinase Inhibitors; Quinazolines; Receptors, Interleukin-6; Signal Transduction; Solubility; Tissue Inhibitor of Metalloproteinases; Urokinase-Type Plasminogen Activator

2012
Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Dec-06, Volume: 108, Issue:49

    Topics: ADAM Proteins; ADAM12 Protein; Amino Acid Substitution; Animals; Arrestins; beta-Arrestins; Blotting, Western; Cell Line; Cell Proliferation; Dipeptides; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Microscopy, Confocal; Mutation; Phosphorylation; Quinazolines; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Transcriptional Activation; Tyrphostins

2011
[Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2013, Volume: 35, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Melanoma; Morpholines; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrphostins

2013
Pb²⁺ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells.
    Environmental toxicology, 2015, Volume: 30, Issue:3

    Topics: Cell Line, Tumor; Environmental Pollutants; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Interleukin-8; Lead; Proto-Oncogene Proteins c-jun; Quinazolines; Stomach Neoplasms; Transcription Factor AP-1; Tyrphostins; Up-Regulation

2015
The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Dec-15, Volume: 191, Issue:12

    Topics: Androstadienes; Antigen Presentation; Antigens, Neoplasm; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, MHC Class I; HLA-A Antigens; Humans; Lapatinib; MAP Kinase Signaling System; Neoplasm Proteins; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; RNA, Small Interfering; Signal Transduction; Stomach Neoplasms; Wortmannin

2013
Transcriptional regulation of Δ6-desaturase by peroxisome proliferative-activated receptor δ agonist in human pancreatic cancer cells: role of MEK/ERK1/2 pathway.
    TheScientificWorldJournal, 2013, Volume: 2013

    Topics: Cell Line, Tumor; ErbB Receptors; Fatty Acid Desaturases; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Signaling System; Pancreatic Neoplasms; PPAR delta; Protein Kinase Inhibitors; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thiazoles; Tyrphostins

2013
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
    Cancer biology & therapy, 2014, Mar-01, Volume: 15, Issue:3

    Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clone Cells; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Flavonoids; Furans; Head and Neck Neoplasms; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyridines; Pyrimidines; Quinazolines; ras Proteins; Signal Transduction

2014
4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts.
    Free radical biology & medicine, 2014, Volume: 71

    Topics: Adult; Aging; Aldehydes; Animals; Aorta; Cell Line, Transformed; Elastin; ErbB Receptors; Fibroblasts; Flavonoids; Gene Expression Regulation; Homeodomain Proteins; Humans; Lipid Peroxidation; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Primary Cell Culture; Protein Transport; Quinazolines; Repressor Proteins; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Tyrphostins

2014
Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.
    British journal of pharmacology, 2014, Volume: 171, Issue:24

    Topics: AIDS Dementia Complex; Animals; Antineoplastic Agents; Cyclin-Dependent Kinase 5; Dasatinib; Erlotinib Hydrochloride; Flavonoids; HIV Envelope Protein gp120; In Vitro Techniques; Indoles; Lapatinib; Mice; Mice, Transgenic; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Protein Kinase Inhibitors; Purines; Pyrimidines; Pyrroles; Quinazolines; Rats; Roscovitine; Sunitinib; Thiazoles

2014
The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Apoptosis; Blotting, Western; Caspases; Cell Proliferation; Flavonoids; Flow Cytometry; Gene Expression Regulation; Gene Silencing; HL-60 Cells; Humans; Immunoprecipitation; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Quinazolines; RNA, Small Interfering; STAT3 Transcription Factor

2014
Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation.
    European journal of pharmacology, 2014, Dec-15, Volume: 745

    Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Chromones; DNA; Dose-Response Relationship, Drug; Flavonoids; Hepatocytes; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Male; MAP Kinase Signaling System; Morpholines; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Transforming Growth Factor alpha; Tyrphostins

2014
Inhibition of hedgehog signalling attenuates UVB-induced skin photoageing.
    Experimental dermatology, 2015, Volume: 24, Issue:8

    Topics: Aging; Anilides; Animals; Cell Line; Cyclooxygenase 2; Cytokines; Drug Evaluation, Preclinical; Flavonoids; Gene Expression Regulation; Hedgehog Proteins; Humans; Inflammation; MAP Kinase Signaling System; Mice; Pyridines; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Skin Aging; Tissue Inhibitor of Metalloproteinase-1; Ultraviolet Rays

2015
The Sbi Protein Contributes to Staphylococcus aureus Inflammatory Response during Systemic Infection.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; Bacterial Proteins; Binding Sites, Antibody; Carrier Proteins; Chemokine CXCL1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Imidazoles; Immunoglobulin G; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neutrophil Infiltration; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Staphylococcal Infections; Staphylococcal Protein A; Staphylococcus aureus; Tyrphostins; Virulence Factors

2015
Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC‑α/ERK1/2 pathway: An in vitro investigation.
    Molecular medicine reports, 2015, Volume: 12, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Flavonoids; Humans; Integrin beta1; Isoflavones; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phorbol Esters; Protein Kinase C-alpha; Pyrroles; Quinazolines; Signal Transduction

2015
Shock wave treatment enhances endothelial proliferation via autocrine vascular endothelial growth factor.
    Genetics and molecular research : GMR, 2015, Dec-29, Volume: 14, Issue:4

    Topics: Autocrine Communication; Cell Proliferation; Cell Survival; Flavonoids; Gene Expression Regulation; High-Energy Shock Waves; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mitogen-Activated Protein Kinase 3; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Ultrasonic Therapy; Vascular Endothelial Growth Factor A

2015
Regulation of Viral Infection-induced Airway Remodeling Cytokine Production by the TLR3-EGFR Signaling Pathway in Human Bronchial Epithelial Cells.
    COPD, 2016, Volume: 13, Issue:6

    Topics: Airway Remodeling; Antiviral Agents; Bronchi; Cells, Cultured; Cytokines; ErbB Receptors; Flavonoids; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mucin 5AC; p38 Mitogen-Activated Protein Kinases; Poly I-C; Protein Kinase Inhibitors; Quinazolines; Respiratory Mucosa; RNA, Messenger; Toll-Like Receptor 3; Transforming Growth Factor beta1; Tyrphostins; Vascular Endothelial Growth Factor A; Virus Diseases

2016
Nitric Oxide and ERK mediates regulation of cellular processes by Ecdysterone.
    Experimental cell research, 2016, 08-15, Volume: 346, Issue:2

    Topics: 3T3-L1 Cells; Aizoaceae; Animals; Cell Migration Assays; Cell Movement; Cell Proliferation; Ecdysterone; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Mice; Nitric Oxide; Quinazolines; Signal Transduction; Tyrphostins

2016
The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Animals; Cells, Cultured; Coronary Vessels; Cyclopentanes; ErbB Receptors; Flavonoids; Humans; In Vitro Techniques; MAP Kinase Signaling System; Models, Cardiovascular; Myocytes, Smooth Muscle; Quinazolines; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Swine; Transcriptional Activation; Tyrphostins; Vasodilation

2018
Crosstalk between BCR-ABL and protease-activated receptor 1 (PAR1) suggests a novel target in chronic myeloid leukemia.
    Experimental hematology, 2018, Volume: 66

    Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Case-Control Studies; Cell Line, Tumor; Chromones; Disease Progression; Dose-Response Relationship, Drug; Female; Flavonoids; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Morpholines; Myeloid Cells; Philadelphia Chromosome; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Treatment Outcome; Vascular Endothelial Growth Factor A

2018
The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 58

    Topics: Angiogenesis Inhibitors; Apelin; Apelin Receptors; Flavonoids; Gene Expression Regulation; Half-Life; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Signaling Peptides and Proteins; Promoter Regions, Genetic; Quinazolines; RNA Stability; RNA, Messenger; Signal Transduction; Wortmannin

2019