Page last updated: 2024-08-21

quinazolines and pd 153035

quinazolines has been researched along with pd 153035 in 163 studies

Research

Studies (163)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.61)18.7374
1990's24 (14.72)18.2507
2000's98 (60.12)29.6817
2010's38 (23.31)24.3611
2020's2 (1.23)2.80

Authors

AuthorsStudies
Bridges, AJ; Cody, DR; Denny, WA; Fry, DW; McMichael, A; Palmer, BD; Rewcastle, GW; Thompson, AM; Zhou, H1
Ambroso, LA; Bridges, AJ; Connors, RW; Fry, DW; Kraker, AJ; Leopold, WR; McMichael, A; Nelson, JM1
Bridges, AJ; Cody, DR; Denny, WA; Fry, DW; Kraker, AJ; McMichael, A; Rewcastle, GW; Showalter, HD; Zhou, H1
Elliott, WL; Hook, KE; Howard, CT; Kunkel, MW; Leopold, WR; Przybranowski, S; Roberts, BJ1
Hollenberg, MD; Zheng, XL1
Fridman, R; Kondapaka, SB; Reddy, KB1
Borgers, S; Hagmann, W1
Fry, DW; Nelson, JM1
Coffey, RJ; Der, CJ; Gangarosa, LM; Graves-Deal, R; Oldham, SM; Sizemore, N1
Elder, J; Garner, W; Stoll, S1
Hamacher, L; Peus, D; Pittelkow, MR1
Hollenberg, MD; Renaux, B; Zheng, XL1
Adjei, PN; Glenn, KS; Gores, GJ; Karnes, WE; Kaufmann, SH; Kottke, TJ; Weller, SG1
Earp, HS; Graves, LM; Lee, JW; Li, X1
Benedict, M; Elder, JT; Hiniker, A; Mitra, R; Nuñez, G; Stoll, SW1
Kumar, R; Singh, P1
Affleck, K; Dean, C; Modjtahedi, H; Stubberfield, C1
Albanell, J; Baselga, J; Bos, M; Fry, DW; Kim, YM; Mendelsohn, J1
Dumin, J; Mast, BA; Parks, WC; Pilcher, BK; Schultz, GS; Schwartz, MJ; Welgus, HG1
Ahola, H; Carlstedt-Duke, J; Modéer, T; Yucel-Lindberg, T1
Damjanovich, S; Jenei, A; Jovin, TM; Kirsch, AK; Nagy, P; Szöllosi, J1
Borgström, P; Eksborg, S; Fredriksson, A; Hassan, M; Ingvar, M; Johnström, P; Kogner, P; Stone-Elander, S; Thorell, JO; von Heijne, G1
Greenberg, NM; Kassis, J; Kim, HG; Lo, H; Moellinger, J; Wells, A1
Ahmed, K; Davis, AT; Faust, RA; Tawfic, S1
Blaudschun, R; Brenneisen, P; Meewes, C; Scharffetter-Kochanek, K; Wlaschek, M1
Beyerle, A; Meves, A; Peus, D; Pittelkow, MR; Vasa, RA1
Balmain, A; Beug, H; Oft, M; Petritsch, C1
Chen, F; Ireland, ME; Mrock, LK1
Brychzy, A; de Paulsen, N; Fournier, MC; Gnarra, JR; Klausner, RD; Lee, S; Pause, A1
Egeblad, M; Jäättelä, M; Mortensen, OH; van Kempen, LC1
Belt, A; Fisher, G; Voorhees, J; Wan, Y; Wang, Z1
Fisher, G; Voorhees, J; Wan, YS; Wang, ZQ1
Diao, C; Hollenberg, MD; Matsubara, S; Wong, NC; Zheng, XL1
Bailly, C; Baldeyrou, B; Bouey-Bencteux, E; Colson, P; Goossens, JF; Hénichart, JP; Houssier, C; Houssin, R; Laine, W1
Klar, U; Lichtner, RB; Menrad, A; Schneider, MR; Sommer, A1
Bennett, TA; Bergmann-Leitner, ES; Hacker, NF; Stetler-Stevenson, WG; Stromberg, K1
Bode, AM; Chen, N; Dong, Z; Liu, G; Ma, WY; She, QB; Wu, E1
Bulloch, AG; Hermann, PM; Wildering, WC1
Chung, HK; Lee, JY; Lee, SJ; Lee, YS; Park, H; Park, YK; Seo, SH; So, IS; Yang, BS1
Li, L; Shaw, PE1
Baatar, D; Pai, R; Pavelka, M; Soreghan, B; Szabo, IL; Tarnawski, AS1
Bode, AM; Chen, N; Dong, Z; Ma, WY; Zhang, Y1
Graves, LM; Jaspers, I; Samet, JM; Wu, W; Zhang, W1
Iimuro, Y; Kawada, N; Okuyama, H; Seki, S; Shimahara, Y; Uyama, N; Yamaoka, Y1
Barrie, E; Kelland, LR; Rowlands, MG; Smith, V; Workman, P1
Meves, A; Peus, D; Pittelkow, MR1
Kassis, J; Klein, G; Maeda, A; Takada, K; Teramoto, N; Wells, A; Wu, C1
Park, SY; Seol, DW1
Boschelli, DH1
Katoh, O; Lu, H; Uesaka, T; Watanabe, H1
Buresi, MC; Buret, AG; Hollenberg, MD; MacNaughton, WK1
Feng, C; Grandis, JR; Li, M; Liu, X; Riedel, F; Ye, C; Zeng, Q1
Chatziantoniou, C; Coffman, T; Dussaule, JC; Flamant, M; Henrion, D; Placier, S; Tharaux, PL1
Blencke, S; Daub, H; Ullrich, A1
Brock, R; Jovin, TM1
Li, J; Majumdar, AP; Xiao, ZQ1
Fredriksson, A; Stone-Elander, S1
Hénichart, JP; Mimeault, M; Pommery, N1
Conzen, SD; Coticchia, CM; Dickson, RB; Nishanian, TG; Ramljak, D; Ringel, MD; Saji, M1
Dewar, BJ; Graves, LM; Samet, JM; Wu, W1
Hidaka, K; Morisaki, T; Suk Kim, H1
Bromberg, PA; Dailey, LA; Graves, LM; Samet, JM; Sheppard, D; Silbajoris, R; Wu, W1
RYE, RM; WISEMAN, D1
Chang, CM; Li, B; McKenna, WG; Shu, HK; Yuan, M1
Bader, B; Glienke, J; Sturz, A; Thierauch, KH1
Lippman, ME; Rae, JM1
Chansel, D; Chatziantoniou, C; Dussaule, JC; Flamant, M; François, H; Placier, S; Tharaux, PL1
Diggle, C; Holder, J; Lee, WC; Selby, PJ; Southgate, J; Stahlschmidt, J; Trejdosiewicz, LK; Varley, CL1
Cho, YM; Foley, J; Gocken, TA; Koltz, PF; Konger, RL; Lewis, DA; Richard, V; Rosol, TJ; Spandau, DF1
Slomiany, A; Slomiany, BL3
Smith, B; Southgate, J; Stahlschmidt, J; Stower, M; Varley, CL1
Eisenmann, C; Klumpp, A; Steinbach, JP; Weller, M1
He, XY; Huang, JA; Jiang, LY; Wang, YD; Xie, W1
Bazan, HE; Bazan, NG; Ottino, P; Sharma, GD1
Baumgarten, CM; Ren, Z1
de Arruda Rolim Filho, L; Franchini, KG; Marin, RM; Rittner, R; Rocco, SA; Velho, JA; Vercesi, AE1
Dai, JR; Deretey, E; Foster, JE; Ng, W; Pasternak, A; Redden, PR; Reid, N; Slon-Usakiewicz, JJ; Toledo-Sherman, L1
Gaiger, A; Grunt, TW; Kainz, B; Puckmair, K; Tomek, K1
Allen, S; Marker, D; Michael, E; Nees, M; Smith, L; Woodworth, CD1
Alleva, AM; Cole, GW; Maxhimer, JB; Nguyen, DM; Reddy, RM; Schrump, DS; Zuo, J1
Hill, G; Pellegrin, S; Selby, PJ; Shaw, NJ; Southgate, J; Trejdosiewicz, LK; Varley, C1
Bökönyi, G; Gyökeres, T; Keri, G; Orfi, L; Pap, A; Petak, I; Schäfer, E; Schwab, R; Szokoloczi, O; Varkondi, E1
Derby, S; Di, W; Jiang, Q; Qiu, L; Schefeller, E; Wan, Y; Wanebo, H; Wang, Q; Yan, B1
Hanakawa, Y; Hashimoto, K; Kagami, S; Kakinuma, T; Komine, M; Tamaki, K1
Iwakura, Y; Jourdi, H; Nagano, T; Namba, H; Nawa, H; Takei, N; Xiong, H1
Gallo, RM; Gilmore, JL; Riese, DJ1
Fox, LH; Howells, LM; Manson, MM; Moiseeva, EP; Temple, LA1
Chakraborty, C; Lala, PK; Timoshenko, AV; Wagner, GF1
Cross, W; Garthwaite, MA; Hinley, J; Southgate, J; Trejdosiewicz, LK; Varley, CL1
Kawakami, T; Olsson, T; Yucel-Lindberg, T1
Di, W; Healey, S; Kouttab, N; Qiu, L; Sun, Y; Wan, Y; Wanebo, H; Yan, B; Zhou, C1
Avila, MA; Berasain, C; Castillo, J; Erroba, E; Lee, DC; Perugorría, MJ; Prieto, J; Santamaría, M1
Chen, H; Fan, ST; Kok, TW; Liu, Y; Poon, RT; Shao, W; Sun, X1
Bi, Z; Li, Y; Wan, Y; Yan, B1
Chen, S; Jia, C; Liu, R; Xia, R; Zhou, Z1
Cereijido, M; Contreras, RG; Flores-Benítez, D; Flores-Maldonado, C; Ruiz-Cabrera, A; Shoshani, L1
Fredriksson, A; Samén, E; Stone-Elander, S; Thorell, JO1
An, J; Rettig, MB1
Gaiger, A; Grunt, TW; Kainz, B; Köhler, G; Puckmair, K; Rünzler, D; Tomek, K; Wagner, R; Zielinski, CC1
Campbell, D; Jackson, CJ; Xue, M1
Hofer, HW; Pfeiffer, T; Schreiner, D; Stenzinger, A; Tag, C; Wimmer, M1
Bassuk, JA; Carmean, N; Hudson, AE; Kosman, JW; Leaf, EM; Opheim, KE1
Chang, XR; Lin, YP; Yan, J; Yang, ZB; Yi, SX; Zhong, Y1
Grunt, TW; Puckmair, K; Tomek, K; Wagner, R; Zielinski, CC1
Song, XR; Sun, XR; Wang, H; Wang, XW; Yang, GR; Yu, JM; Zhao, SQ; Zhao, W1
Mu, D; Song, X; Sun, X; Wang, H; Yang, G; Yu, J; Zhao, S1
Cheon, H; Cho, S; Kim, HJ; Kim, HS; Lee, JY; Sohn, J; Won, NH; Woo, YS1
Amaral, A; Cao, C; Chu, W; Di, W; Kivlin, R; Lu, S; Sowa, A; Wan, Y; Yang, H1
Cai, H; Duan, W; Fu, L; Jiang, H; Li, L; Mei, C; Wang, L; Xiong, X1
Breza, N; Keri, G; Orfi, L; Petak, I; Pinter, F; Robert, K; Schwab, R; Varkondi, E1
Bi, K; Echeverria, VM; Honer, J; Machleidt, T; Vandenheuvel-Kramer, K; Wilkinson, JM; Zhong, Z1
Fu, Z; Liu, YL; Mu, DB; Song, B; Song, XR; Teng, XP; Wang, H; Wang, XW; Wei, L; Yang, GR; Yu, JM; Zhao, SQ1
Beales, IL; Ogunwobi, OO1
Iyengar, L; Lovicu, FJ; McAvoy, JW; Patkunanathan, B1
Tzeng, DW; Wang, CY; Wang, YT; Yang, JL1
Dong, Z; Fu, L; Gao, X; Ji, C; Li, L; Liu, H; Luo, X; Mei, C; Xiong, X; Zhang, Y1
Fu, Z; Li, M; Li, X; Liu, N; Ma, L; Meng, X; Yang, G; Yang, Y; Yu, J; Zhao, S1
Chen, XG; Feng, ZQ; Li, J; Liu, Y; Meng, Y1
Futamura, K; Hashimoto, N; Matsumoto, K; Muro, Y; Nagasaka, T; Nishizawa, Y; Saito, H; Sugiura, K; Tomita, Y; Usukura, J1
Biasco, G; Boschi, S; Fanti, S; Lollini, PL; Nannini, M; Pantaleo, MA1
Kawanishi, M; Koizumi, K; Nishimura, M; Saiki, I; Sakurai, H; Shin, MS; Singhirunnusorn, P; Suzuki, S1
Carvalheira, JB; Cintra, DE; de Souza, CT; Franchini, KG; Mourão, RH; Pauli, JR; Prada, PO; Rittner, R; Rocco, SA; Ropelle, ER; Saad, MJ; Schenka, A; Vassallo, J; Velloso, LA1
Blum, H; Bruns, CJ; Camaj, P; De Toni, EN; Faktorova, D; Ischenko, I; Jauch, KW; Krebs, S; Seeliger, H1
Castilho, RF; Cavalheiro, RA; Cerqueira, FM; da Silva, CC; Franchini, KG; Kowaltowski, AJ; Marin, RM; Rittner, R; Rocco, SA; Vercesi, AE1
Fozing, T; Samnick, S; Scheuer, C1
Muro, Y; Shimoyama, Y; Sugiura, K; Tomita, Y; Yamaki, M1
Li, X; Li, Z; Lv, Y; Ma, Y; Yi, S; Yuan, A1
Fridberger, A; Gont, C; Kirkegaard, M; Mannström, P; Matsumoto, S; Ulfendahl, M; Watanabe, F1
Chen, ZC; Guan, YJ; Li, C; Li, MY; Li, XH; Liang, K; Peng, F; Tang, CE; Xiao, ZQ; Yao, KT; Yi, B; Yi, H; Zhang, PF; Zou, HY1
Hirata, M; Kagawa, S; Kanai, Y; Matsumuro, K; Naka, S; Ohmomo, Y; Yoshimoto, M1
Haramoto, M; Horibe, T; Kawakami, K; Kohno, M; Matsuzaki, K; Nakajima, O; Ohara, K; Yano, Y1
Cheng, CM; Hsu, CT; Lee, YJ; Ou, KL; Tsai, JS; Wang, WT; Wu, CM; Yang, TS1
Partridge, NC; Qin, L; Shimizu, E; Zhang, X; Zhu, J1
Loo, BW; Ma, L; Meng, X; Murphy, JD; Sun, X; Yu, J1
Pick, A; Wiese, M1
Akama-Garren, EH; Edalati, A; Lindstrom, TM; Petralia, JD; Robinson, WH; Ruiz, PJ; Stein, EA; Swanson, CD1
Fu, Z; Ge, H; Liu, H; Sun, Z1
Gong, K; Li, X; Liu, W; Luo, K; Wang, K1
Matsuo, K; Takada, Y1
Eda, T; Iwakura, Y; Mizuno, M; Nagata, K; Namba, H; Nawa, H; Okubo, T; Shibuya, M; Sotoyama, H; Wang, R1
Nguyen, DM; Xin, HW; Yang, JH1
Arndt-Jovin, DJ; Bunt, G; Fritsch, C; Jovin, TM; Klement, R; Klymchenko, AS; Loman, A; Ziomkiewicz, I1
Arnberg, F; Holmin, S; Lu, L; Olofsson, MH; Samén, E; Stone-Elander, S; Tegnebratt, T; Thorell, JO1
Chang, CM; Chang, WC; Chuang, HY; Hou, MF; Lee, YC; Lin, YC; Tsai, YT; Wang, JY; Wei, PL; Wong, JH1
Cai, L; Gao, S; Pu, P; Sun, J; Yang, W; Zhang, A; Zhang, K1
Leon Carrion, S; Sutter, CH; Sutter, TR1
Angelini, M; Benaiteau, F; Fleury, F; Gyulkhandanyan, A; Gyulkhandanyan, L; Le Béchec, M; Lecocq, MF; Logé, C; Reiter, E; Roussakis, C; Rousseau, B; Sakanyan, V1
Baltus, CB; Chuckowree, IS; Librizzi, M; Longo, A; Luparello, C; Spencer, J1
Liu, W; Qin, ZP; Xing, RC; Yao, RC; Zheng, J; Zheng, WH1
Dai, D; Li, XF; Liu, JJ; Wang, J; Wang, Q; Xu, WG; Zhang, Y; Zhu, YJ1
Campion, CM; Cole, JA; Leon Carrion, S; Mamidanna, G; Sutter, CH; Sutter, TR1
Hartel, I; Rieger, J; Ronellenfitsch, M; Steinbach, JP; Wanka, C; Wolking, S1
Alqahtani, S; Ashby, CR; Bates, SE; Chen, ZS; Deng, T; Gupta, P; Kaddoumi, A; Lei, YX; Wang, YJ; Wurpel, JND; Zhang, GN; Zhang, YK1
Abisoye-Ogunniyan, A; Davis, M; Ghebremedhin, A; Grizzle, W; Jones-Trich, J; Karanam, B; Lin, H; Salam, AB; Theodore, S; Wang, H; Yates, C1
Harter, PN; Mittelbronn, M; Pietsch, T; Reuter, D; Ronellenfitsch, MW; Senft, C; Steinbach, JP; Urban, H; Westphal, M; Zeiner, PS1
Lovicu, FJ; Shu, DY; Wojciechowski, M1
Cao, M; Chen, S; Du, J; Song, W; Wu, X; Xia, R1
Choung, S; Joung, KH; Kim, HJ; Kim, JM; Ku, BJ; Lee, ES1
Aoi, T; Fujisawa, M; Hinata, N; Koyanagi-Aoi, M; Suzuki, K; Uehara, K1
Furue, K; Furue, M; Ito, T; Nakahara, T; Tsuji, G1
Bergum, N; Garrett, SH; Knutson, P; Mehus, AA; Sens, DA; Sens, MA; Shrestha, S; Somji, S; Zhou, XD1

Reviews

2 review(s) available for quinazolines and pd 153035

ArticleYear
4-anilino-3-quinolinecarbonitriles: an emerging class of kinase inhibitors.
    Current topics in medicinal chemistry, 2002, Volume: 2, Issue:9

    Topics: Aniline Compounds; Animals; Enzyme Inhibitors; ErbB Receptors; Inhibitory Concentration 50; Nitriles; Protein Binding; Protein Serine-Threonine Kinases; Quinazolines; src-Family Kinases; Tumor Cells, Cultured

2002
PET screening of anticancer drugs. A faster route to drug/target evaluations in vivo.
    Methods in molecular medicine, 2003, Volume: 85

    Topics: Animals; Antineoplastic Agents; Drug Evaluation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Haplorhini; Humans; Image Processing, Computer-Assisted; Isotope Labeling; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Quinazolines; Radiopharmaceuticals; Rats; Tomography, Emission-Computed; Xenograft Model Antitumor Assays

2003

Trials

2 trial(s) available for quinazolines and pd 153035

ArticleYear
A pilot study on EGFR-targeted molecular imaging of PET/CT With 11C-PD153035 in human gliomas.
    Clinical nuclear medicine, 2014, Volume: 39, Issue:1

    Topics: Adult; Aged; Biological Transport; Carbon Radioisotopes; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Middle Aged; Multimodal Imaging; Pilot Projects; Positron-Emission Tomography; Quinazolines; Tomography, X-Ray Computed

2014
Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma.
    Acta neuropathologica communications, 2018, 08-21, Volume: 6, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Antibodies, Monoclonal, Humanized; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Calcium-Binding Proteins; Cohort Studies; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; ErbB Receptors; Female; Glioblastoma; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Microfilament Proteins; Necrosis; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Ribosomal Protein S6; Signal Transduction; Time Factors; Treatment Outcome; Tumor Suppressor Proteins

2018

Other Studies

159 other study(ies) available for quinazolines and pd 153035

ArticleYear
Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor.
    Journal of medicinal chemistry, 1996, Apr-26, Volume: 39, Issue:9

    Topics: ErbB Receptors; Humans; Isomerism; Magnetic Resonance Spectroscopy; Phosphorylation; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured

1996
A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.
    Science (New York, N.Y.), 1994, Aug-19, Volume: 265, Issue:5175

    Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Gene Expression; Humans; Kinetics; Mice; Mitosis; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrosine

1994
Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.
    Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1

    Topics: Aniline Compounds; Binding Sites; Blotting, Western; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Conformation; Molecular Structure; Phosphorylation; Protein Binding; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured

1996
Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice.
    Investigational new drugs, 1996, Volume: 13, Issue:4

    Topics: Animals; Carcinoma, Squamous Cell; Cell Division; Enzyme Inhibitors; ErbB Receptors; Humans; Mice; Mice, Nude; Neoplasms; Quinazolines; Transplantation, Heterologous; Tumor Cells, Cultured

1996
Tyrosine kinase inhibitor-sensitive contractile action of ethanol in gastric smooth muscle: comparison with the action of epidermal growth factor.
    Proceedings of the Association of American Physicians, 1997, Volume: 109, Issue:1

    Topics: 1-Propanol; Animals; Calcium; Catechols; Cyclohexanones; Enzyme Inhibitors; Epidermal Growth Factor; Ethanol; Fomepizole; Genistein; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Indomethacin; Isoflavones; Male; Maleimides; Methanol; Muscle Contraction; Muscle, Smooth; Nitriles; Protein-Tyrosine Kinases; Pyrazoles; Quinazolines; Signal Transduction; Stomach; Tyrphostins

1997
Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells.
    International journal of cancer, 1997, Mar-17, Volume: 70, Issue:6

    Topics: Amphiregulin; Antineoplastic Agents; Breast Neoplasms; Cell Division; Collagenases; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gelatinases; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Neoplasm Metastasis; Quinazolines; Tumor Cells, Cultured; Up-Regulation

1997
Requirement for epidermal growth factor receptor tyrosine kinase and for 12-lipoxygenase activity in the expression of 12-lipoxygenase in human epidermoid carcinoma cells.
    Biochemical pharmacology, 1997, Apr-04, Volume: 53, Issue:7

    Topics: Arachidonate 12-Lipoxygenase; Biotin; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Down-Regulation; ErbB Receptors; Humans; Lipoxygenase Inhibitors; Phalloidine; Phthalimides; Quinazolines; RNA, Messenger; Tumor Cells, Cultured

1997
Cytoskeletal and morphological changes associated with the specific suppression of the epidermal growth factor receptor tyrosine kinase activity in A431 human epidermoid carcinoma.
    Experimental cell research, 1997, Jun-15, Volume: 233, Issue:2

    Topics: Actins; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Division; Cytoskeleton; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured

1997
A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells.
    The Journal of biological chemistry, 1997, Jul-25, Volume: 272, Issue:30

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Enzyme Inhibitors; ErbB Receptors; Intestinal Mucosa; Ligands; Oncogene Protein pp60(v-src); Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Rats; RNA, Messenger; Transforming Growth Factor alpha; Up-Regulation

1997
Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture.
    The Journal of clinical investigation, 1997, Sep-01, Volume: 100, Issue:5

    Topics: Adult; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Organ Culture Techniques; Quinazolines; Skin; Wound Healing

1997
EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation.
    The Journal of investigative dermatology, 1997, Volume: 109, Issue:6

    Topics: Antibodies, Monoclonal; Cell Differentiation; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Keratinocytes; Phosphorylation; Quinazolines

1997
Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:1

    Topics: Animals; Arachidonic Acid; Calcium; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Lipoprotein Lipase; Male; Mitogen-Activated Protein Kinase Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Receptors, Thrombin; Signal Transduction

1998
Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells.
    Gastroenterology, 1998, Volume: 114, Issue:5

    Topics: Apoptosis; Colonic Neoplasms; Endopeptidases; Enzyme Inhibitors; ErbB Receptors; Humans; Ligands; Protease Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1998
Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathway.
    The EMBO journal, 1998, May-01, Volume: 17, Issue:9

    Topics: Angiotensin II; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; GTP-Binding Proteins; Humans; Liver; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation

1998
EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL.
    Oncogene, 1998, Volume: 16, Issue:11

    Topics: Antibodies, Monoclonal; Apoptosis; bcl-X Protein; Enzyme Inhibitors; ErbB Receptors; Humans; Keratinocytes; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction

1998
Inhibitors of the epidermal growth factor receptor protein tyrosine kinase: a quantitative structure-activity relationship analysis.
    Journal of enzyme inhibition, 1998, Volume: 13, Issue:2

    Topics: Drug Design; Enzyme Inhibitors; ErbB Receptors; Models, Statistical; Molecular Structure; Quinazolines; Regression Analysis; Structure-Activity Relationship

1998
EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5.
    International journal of oncology, 1998, Volume: 13, Issue:2

    Topics: Antibodies, Monoclonal; Apoptosis; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Enzyme Inhibitors; ErbB Receptors; Head and Neck Neoplasms; Humans; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrosine

1998
PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:11

    Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Enzyme Inhibitors; ErbB Receptors; Female; Genes, erbB-2; Humans; Male; Phosphorylation; Prostatic Neoplasms; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Transfection; Uterine Cervical Neoplasms; Vulvar Neoplasms

1997
Keratinocyte collagenase-1 expression requires an epidermal growth factor receptor autocrine mechanism.
    The Journal of biological chemistry, 1999, Apr-09, Volume: 274, Issue:15

    Topics: Animals; Burns; Cell Movement; Cells, Cultured; Collagenases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Humans; In Situ Hybridization; Keratinocytes; Male; Matrix Metalloproteinase 1; Quinazolines; Swine; Transfection; Wound Healing

1999
Involvement of tyrosine kinases on cyclooxygenase expression and prostaglandin E2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor.
    Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2

    Topics: Benzoquinones; Cells, Cultured; Child; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Interleukin-1; Isoenzymes; Lactams, Macrocyclic; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Quinazolines; Quinones; Rifabutin; RNA, Messenger; Sulfonamides; Time Factors

1999
Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy.
    Journal of cell science, 1999, Volume: 112 ( Pt 11)

    Topics: Animals; CHO Cells; Cricetinae; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Microscopy, Atomic Force; Microscopy, Confocal; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Tumor Cells, Cultured

1999
In vivo evaluation of the biodistribution of 11C-labeled PD153035 in rats without and with neuroblastoma implants.
    Life sciences, 1999, Volume: 65, Issue:2

    Topics: Animals; Carbon Radioisotopes; ErbB Receptors; Evaluation Studies as Topic; Female; Humans; Neoplasm Transplantation; Neuroblastoma; Quinazolines; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tomography, Emission-Computed; Tumor Cells, Cultured

1999
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:8

    Topics: Adenocarcinoma; Animals; Autocrine Communication; Breast Neoplasms; Cell Line; Diffusion Chambers, Culture; Epidermal Growth Factor; ErbB Receptors; Estrenes; Female; Humans; Immunoblotting; Isoenzymes; Male; Mice; Neoplasm Invasiveness; Phosphodiesterase Inhibitors; Phospholipase C gamma; Phosphorylation; Prostatic Neoplasms; Pyrrolidinones; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Type C Phospholipases

1999
Apoptosis and growth inhibition of head and neck tumor cell line induced by epidermal growth factor receptor tyrosine kinase inhibitor.
    Oral oncology, 1999, Volume: 35, Issue:3

    Topics: Apoptosis; Carcinoma, Squamous Cell; Enzyme Inhibitors; ErbB Receptors; Gingival Neoplasms; Humans; Quinazolines; Tumor Cells, Cultured

1999
The first peak of the UVB irradiation-dependent biphasic induction of vascular endothelial growth factor (VEGF) is due to phosphorylation of the epidermal growth factor receptor and independent of autocrine transforming growth factor alpha.
    FEBS letters, 2000, Jun-02, Volume: 474, Issue:2-3

    Topics: Antibodies; Autocrine Communication; Cell Line; Endothelial Growth Factors; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epidermal Cells; Epidermis; ErbB Receptors; Humans; Lymphokines; Models, Biological; Phosphorylation; Protein Isoforms; Quinazolines; RNA, Messenger; Time Factors; Transforming Growth Factor alpha; Ultraviolet Rays; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival.
    Photochemistry and photobiology, 2000, Volume: 72, Issue:1

    Topics: Cell Survival; Cells, Cultured; ErbB Receptors; Humans; Keratinocytes; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Signal Transduction; Ultraviolet Rays

2000
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest.
    Genes & development, 2000, Dec-15, Volume: 14, Issue:24

    Topics: Activin Receptors, Type I; Androstadienes; Animals; Cells, Cultured; Chromones; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Fibroblasts; G1 Phase; Morpholines; Mutation; Phosphoprotein Phosphatases; Phosphorylation; Protein Biosynthesis; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Quinazolines; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Ribosomal Protein S6 Kinases; S Phase; Signal Transduction; Sirolimus; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Wortmannin

2000
A role for endogenous TGFalpha and associated signaling pathways in the differentiation of lens fiber cells.
    Journal of cellular physiology, 2001, Volume: 186, Issue:2

    Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Chickens; Cyclic AMP; Enzyme Inhibitors; ErbB Receptors; Eye Proteins; Intermediate Filament Proteins; Isoproterenol; Lens, Crystalline; Mitogen-Activated Protein Kinase 1; Phosphorylation; Quinazolines; Receptor Cross-Talk; Signal Transduction; Transforming Growth Factor alpha

2001
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Feb-13, Volume: 98, Issue:4

    Topics: Adenocarcinoma, Clear Cell; Cell Division; Cell Hypoxia; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Genes, Tumor Suppressor; Growth Substances; Humans; Insulin; Kidney Neoplasms; Ligases; Oligodeoxyribonucleotides, Antisense; Proteins; Quinazolines; Selenium; Transferrin; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins; Ubiquitin-Protein Ligases; von Hippel-Lindau Disease; Von Hippel-Lindau Tumor Suppressor Protein

2001
BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.
    Biochemical and biophysical research communications, 2001, Feb-16, Volume: 281, Issue:1

    Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoblotting; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuregulin-1; Organic Chemicals; Phosphorylation; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Recombinant Proteins; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2001
Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.
    International journal of molecular medicine, 2001, Volume: 7, Issue:3

    Topics: Blotting, Western; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Interleukin-1; Keratinocytes; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Models, Biological; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinazolines; Time Factors; Tyrphostins

2001
EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes.
    Cellular signalling, 2001, Volume: 13, Issue:2

    Topics: Adult; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Glutathione Transferase; Humans; Interleukin-1; Interleukin-1 Receptor-Associated Kinases; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Kinases; Quinazolines; Signal Transduction; Skin; Time Factors; Transcription Factor AP-1; Ultraviolet Rays

2001
Epidermal growth factor induction of apolipoprotein A-I is mediated by the Ras-MAP kinase cascade and Sp1.
    The Journal of biological chemistry, 2001, Apr-27, Volume: 276, Issue:17

    Topics: Amino Acid Sequence; Apolipoprotein A-I; Binding Sites; Blotting, Western; Chloramphenicol O-Acetyltransferase; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genes, Dominant; Genes, ras; Genes, Reporter; Humans; Insulin; MAP Kinase Signaling System; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Protein Synthesis Inhibitors; Quinazolines; ras Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sp1 Transcription Factor; Threonine; Time Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Up-Regulation

2001
DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.
    Biochemistry, 2001, Apr-17, Volume: 40, Issue:15

    Topics: Antineoplastic Agents; Base Sequence; Binding Sites; Circular Dichroism; Densitometry; DNA; DNA Footprinting; DNA, Superhelical; Electrophoresis, Agar Gel; Enzyme Inhibitors; ErbB Receptors; Humans; Intercalating Agents; Molecular Sequence Data; Protein Denaturation; Quinazolines; Spectrometry, Fluorescence

2001
Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.
    Cancer research, 2001, Aug-01, Volume: 61, Issue:15

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Kinetics; Ligands; Lung Neoplasms; Mammary Neoplasms, Experimental; Phthalimides; Quinazolines; Rats; Signal Transduction; Tumor Cells, Cultured

2001
Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells.
    Journal of the National Cancer Institute, 2001, Sep-19, Volume: 93, Issue:18

    Topics: Antigens, CD; Autocrine Communication; Carcinoma; Cell Adhesion; Cell Movement; Cell Size; DNA, Antisense; DNA, Complementary; Enzyme Induction; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin alpha3; Integrin alpha6; Integrins; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Proteins; Ovarian Neoplasms; Phenotype; Quinazolines; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transfection; Tumor Cells, Cultured

2001
Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.
    The Journal of biological chemistry, 2001, Dec-14, Volume: 276, Issue:50

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Ligands; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Phenylalanine; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Quinazolines; Signal Transduction; Tetradecanoylphorbol Acetate; Thiophenes; Transcription Factor AP-1; Transcriptional Activation; Tyrphostins

2001
Lymnaea epidermal growth factor promotes axonal regeneration in CNS organ culture.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Dec-01, Volume: 21, Issue:23

    Topics: Animals; Axons; Carbazoles; Central Nervous System; Disease Models, Animal; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Indole Alkaloids; Lymnaea; Nerve Crush; Nerve Regeneration; Neurons; Organ Culture Techniques; Quinazolines; Reproducibility of Results

2001
1,4-dioxane-fused 4-anilinoquinazoline as inhibitors of epidermal growth factor receptor kinase.
    Archiv der Pharmazie, 2001, Volume: 334, Issue:11

    Topics: Antineoplastic Agents; Cell Division; Dioxanes; ErbB Receptors; Humans; Protein-Tyrosine Kinases; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured

2001
Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines.
    The Journal of biological chemistry, 2002, May-17, Volume: 277, Issue:20

    Topics: Breast Neoplasms; Cell Division; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Female; Humans; Oncogene Proteins v-erbB; Phosphorylation; Quinazolines; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Tyrphostins

2002
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
    Nature medicine, 2002, Volume: 8, Issue:3

    Topics: Animals; Cell Line; Colonic Neoplasms; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Gastric Mucosa; Genes, src; Humans; Hypertrophy; MAP Kinase Signaling System; Matrix Metalloproteinases; Mitogen-Activated Protein Kinase 1; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Transcriptional Activation; Tyrphostins

2002
Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation.
    DNA and cell biology, 2001, Volume: 20, Issue:12

    Topics: Animals; Blotting, Western; Cell Line; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Quinazolines; Ribosomal Protein S6 Kinases; Signal Transduction; Transfection; Tyrosine; Tyrphostins; Ultraviolet Rays

2001
Role of Ras in metal-induced EGF receptor signaling and NF-kappaB activation in human airway epithelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:5

    Topics: Arsenic; Bronchi; Cell Line, Transformed; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; I-kappa B Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Metals; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Quinazolines; Respiratory Mucosa; Vanadium; Zinc

2002
Regulation of cultured rat hepatocyte proliferation by stellate cells.
    Journal of hepatology, 2002, Volume: 36, Issue:5

    Topics: Albumins; Animals; Anti-Ulcer Agents; Anticoagulants; Antineoplastic Agents; Carbenoxolone; Cell Communication; Cell Count; Cell Division; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; DNA; ErbB Receptors; Gap Junctions; Heparan Sulfate Proteoglycans; Heparin; Heparitin Sulfate; Hepatocyte Growth Factor; Hepatocytes; Male; Proto-Oncogene Proteins c-met; Quinazolines; Rats; Rats, Wistar; Specific Pathogen-Free Organisms

2002
Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:6

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Blotting, Western; Cell Division; Chromones; Colorectal Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Farnesyltranstransferase; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Quinolones; Transfection; Tumor Cells, Cultured

2002
Okadaic acid-induced EGF receptor and MAP kinase activation does not require reactive oxygen species in primary keratinocytes.
    Archives of dermatological research, 2002, Volume: 294, Issue:5

    Topics: Carcinogens; Cells, Cultured; Enzyme Activation; ErbB Receptors; Humans; Keratinocytes; Lipid Peroxidation; Mitogen-Activated Protein Kinases; Okadaic Acid; Quinazolines; Reactive Oxygen Species

2002
EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness.
    International journal of cancer, 2002, Jun-10, Volume: 99, Issue:5

    Topics: Carcinoma, Signet Ring Cell; Cell Movement; Collagen; Drug Combinations; Enzyme Inhibitors; ErbB Receptors; Estrenes; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Herpesvirus 4, Human; Humans; Integrins; Isoenzymes; Laminin; Neoplasm Invasiveness; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Pyrrolidinones; Quinazolines; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured; Type C Phospholipases

2002
Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis.
    Biochemical and biophysical research communications, 2002, Jul-12, Volume: 295, Issue:2

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line; ErbB Receptors; Genistein; Membrane Glycoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Recombinant Proteins; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

2002
Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:4

    Topics: Animals; CDX2 Transcription Factor; Cell Division; Cell Line; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Homeodomain Proteins; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Male; Mice; Promoter Regions, Genetic; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Transcription, Genetic; Transfection

2002
Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:12

    Topics: Androstadienes; Butadienes; Cell Line; Chlorides; Epithelial Cells; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Nitriles; Nitrobenzenes; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Pyridines; Pyrimidines; Quinazolines; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Sulfonamides; Thrombin; Tyrphostins; Wortmannin

2002
Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:11

    Topics: Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Division; Cells, Cultured; Collagen; Down-Regulation; Endostatins; Endothelium, Vascular; ErbB Receptors; Humans; Immunohistochemistry; Liposomes; Mice; Mice, Inbred C3H; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Oligonucleotides, Antisense; Peptide Fragments; Plasmids; Quinazolines; Recombinant Proteins; Time Factors; Transfection; Tumor Cells, Cultured; Umbilical Veins

2002
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:2

    Topics: Animals; Aorta; Blood Pressure; Collagen Type I; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibrosis; Flavonoids; In Vitro Techniques; Luciferases; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Quinazolines; Tyrphostins; Vasoconstriction

2003
Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors.
    The Journal of biological chemistry, 2003, Apr-25, Volume: 278, Issue:17

    Topics: Animals; Antineoplastic Agents; Benzamides; Cell Line; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Humans; Imatinib Mesylate; MAP Kinase Signaling System; Piperazines; Point Mutation; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Threonine; Transfection

2003
Quantitative image analysis of cellular protein translocation induced by magnetic microspheres: application to the EGF receptor.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2003, Volume: 52, Issue:1

    Topics: Animals; Cell Line, Tumor; CHO Cells; Cricetinae; Enzyme Inhibitors; ErbB Receptors; Fluorescent Dyes; Green Fluorescent Proteins; Humans; Image Processing, Computer-Assisted; Luminescent Proteins; Magnetics; Microscopy, Confocal; Microscopy, Fluorescence; Microspheres; Models, Biological; Protein Transport; Quinazolines; Signal Transduction; Time Factors

2003
Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:2

    Topics: Aging; Animals; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Gastric Mucosa; Male; Mitogen-Activated Protein Kinase Kinases; Pyrimidines; Quinazolines; Rats; Rats, Inbred F344; Signal Transduction; src-Family Kinases; Transcription Factor AP-1; Transforming Growth Factor alpha

2003
Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
    International journal of cancer, 2003, Aug-10, Volume: 106, Issue:1

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Cell Division; Cell Separation; Ceramides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Male; Membrane Potentials; Mitochondria; Necrosis; Prostatic Neoplasms; Protease Inhibitors; Quinazolines; Tumor Cells, Cultured

2003
Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells.
    Experimental cell research, 2003, Jul-15, Volume: 287, Issue:2

    Topics: Animals; Apoptosis; bcl-X Protein; Butadienes; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Quinazolines; Up-Regulation

2003
Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.
    Toxicology and applied pharmacology, 2003, Aug-15, Volume: 191, Issue:1

    Topics: Blotting, Western; Cell Line; Detergents; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Genes, src; Humans; Phosphorylation; Quinazolines; Signal Transduction; Transcriptional Activation; Zinc

2003
Expression of ErbB receptors in ES cell-derived cardiomyocytes.
    Biochemical and biophysical research communications, 2003, Sep-12, Volume: 309, Issue:1

    Topics: Animals; Apoptosis; Cell Differentiation; Cell Division; Culture Media, Serum-Free; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Green Fluorescent Proteins; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Luminescent Proteins; Mice; Mice, Transgenic; Microscopy, Fluorescence; Myocardium; Neuregulin-1; Quinazolines; Receptor, ErbB-4; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stem Cells; Time Factors; Transcription Factors; Tyrphostins; Xenopus Proteins

2003
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.
    American journal of respiratory cell and molecular biology, 2004, Volume: 30, Issue:4

    Topics: Antibodies; Bronchi; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Matrix Metalloproteinase Inhibitors; Phosphorylation; Quinazolines; Tyrosine; Zinc

2004
RELEASE OF PHOSPHORUS-32-CONTAINING COMPOUNDS FROM MICROCOCCUS LYSODEIKTICUS TREATED WITH CHLORHEXIDINE.
    The Journal of pharmacy and pharmacology, 1964, Volume: 16

    Topics: Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Micrococcus; Pharmacology; Phosphorus; Phosphorus Isotopes; Quinazolines; Research

1964
Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas.
    Cancer research, 2003, Nov-01, Volume: 63, Issue:21

    Topics: Antineoplastic Agents; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p27; DNA-Binding Proteins; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Glioma; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; STAT3 Transcription Factor; Trans-Activators; Tumor Suppressor Proteins

2003
EphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration.
    Biochemical and biophysical research communications, 2004, Jan-02, Volume: 313, Issue:1

    Topics: Animals; Cell Movement; Cells, Cultured; CHO Cells; Cricetinae; Endothelium, Vascular; Enzyme Inhibitors; Ephrin-B2; ErbB Receptors; Humans; Microcirculation; Phosphorylation; Pyrimidines; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, EphB4; Recombinant Proteins; Signal Transduction; src-Family Kinases; Vascular Endothelial Growth Factors

2004
Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors.
    Breast cancer research and treatment, 2004, Volume: 83, Issue:2

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Quinazolines

2004
Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:7

    Topics: Animals; Capillaries; Collagen; Collagen Type I; Creatinine; Endothelin-1; ErbB Receptors; Fibrosis; Gefitinib; Gene Expression Regulation; Genes, Reporter; Glomerulosclerosis, Focal Segmental; Hypertension; Ischemia; Kidney; Kidney Cortex; Kidney Diseases; Kidney Glomerulus; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proteinuria; Quinazolines; Rats; Rats, Sprague-Dawley

2004
Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme.
    Journal of cell science, 2004, Apr-15, Volume: 117, Issue:Pt 10

    Topics: Active Transport, Cell Nucleus; Adipocytes; Anilides; Animals; Blotting, Western; Cattle; Cell Differentiation; Cell Line; Cell Proliferation; Chromans; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Gene Expression Regulation; Humans; Immunoprecipitation; Ligands; Membrane Glycoproteins; Membrane Proteins; Microscopy, Fluorescence; Phosphorylation; PPAR gamma; Promoter Regions, Genetic; Quinazolines; Ribonucleases; RNA, Messenger; Signal Transduction; Thiazolidinediones; Time Factors; Troglitazone; Uroplakin Ia; Uroplakin Ib; Uroplakin II; Uroplakin III; Urothelium

2004
Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes.
    The Journal of endocrinology, 2004, Volume: 181, Issue:1

    Topics: Adult; Amphiregulin; Antibodies, Monoclonal; Bacterial Proteins; Cell Division; Cells, Cultured; Dactinomycin; EGF Family of Proteins; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression Regulation; Genes, erbB-1; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Infant, Newborn; Intercellular Signaling Peptides and Proteins; Keratinocytes; Parathyroid Hormone-Related Protein; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha

2004
Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.
    Biochemical and biophysical research communications, 2004, May-21, Volume: 318, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Androstadienes; Animals; Bucladesine; Choline; Colforsin; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Isoproterenol; Phosphoinositide-3 Kinase Inhibitors; Phospholipids; Pyrimidines; Quinazolines; Rats; Receptors, Adrenergic, beta; Saliva; src-Family Kinases; Sublingual Gland; Transcriptional Activation; Wortmannin

2004
Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells.
    The American journal of pathology, 2004, Volume: 164, Issue:5

    Topics: Cell Differentiation; Chromans; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoblotting; Immunohistochemistry; Keratins; Metaplasia; Microscopy, Fluorescence; Quinazolines; Receptors, Cytoplasmic and Nuclear; Ribonucleases; RNA, Messenger; Signal Transduction; Thiazolidinediones; Transcription Factors; Troglitazone; Urothelium

2004
Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis.
    Biochemical and biophysical research communications, 2004, Aug-27, Volume: 321, Issue:3

    Topics: Apoptosis; Brain Neoplasms; Caspase 8; Caspases; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Fas Ligand Protein; Glioma; Humans; Membrane Glycoproteins; Quinazolines; Receptor, IGF Type 1; Ribosomal Protein S6; Signal Transduction; Tumor Suppressor Protein p53; Tyrphostins

2004
[Role of PD153035 in the induction of apoptosis of XG-1 myeloma cell line].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2004, Volume: 26, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; DNA-Binding Proteins; ErbB Receptors; Humans; Multiple Myeloma; Quinazolines; STAT3 Transcription Factor; Trans-Activators

2004
Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis.
    The Journal of biological chemistry, 2005, Mar-04, Volume: 280, Issue:9

    Topics: Arachidonate 15-Lipoxygenase; Blotting, Western; Cell Membrane; Cell Proliferation; Cells, Cultured; Chromatography, High Pressure Liquid; Cornea; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Green Fluorescent Proteins; Hepatocyte Growth Factor; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Lipoxygenase; MAP Kinase Kinase Kinases; Microscopy, Fluorescence; Models, Biological; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Transport; Quinazolines; Signal Transduction; Time Factors; Transfection; Wound Healing

2005
Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:6

    Topics: Animals; Cadmium; Chloride Channels; Enzyme Inhibitors; ErbB Receptors; Genistein; Heart Ventricles; Membrane Potentials; Pyrimidines; Quinazolines; Rabbits; src-Family Kinases; Tamoxifen; Ventricular Function

2005
High performance liquid chromatography analysis of a 4-anilinoquinazoline derivative (PD153035), a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in rat plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Mar-25, Volume: 817, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Enzyme Inhibitors; ErbB Receptors; Male; Quinazolines; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet

2005
Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery.
    Analytical chemistry, 2005, Mar-01, Volume: 77, Issue:5

    Topics: Alkaloids; Animals; Benzophenanthridines; Binding Sites; Binding, Competitive; Catalytic Domain; Chromatography, Affinity; Drug Evaluation, Preclinical; Humans; Imidazoles; Mass Spectrometry; Mice; Molecular Structure; Peptides; Phosphorylation; Protein Binding; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Quinazolines; Receptor, EphB2; Recombinant Proteins

2005
An EGF receptor inhibitor induces RAR-beta expression in breast and ovarian cancer cells.
    Biochemical and biophysical research communications, 2005, Apr-22, Volume: 329, Issue:4

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; ErbB Receptors; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Ovarian Neoplasms; Promoter Regions, Genetic; Quinazolines; Receptor, ErbB-2; Receptors, Retinoic Acid; RNA, Messenger

2005
Porphyromonas gingivalis lipopolysaccharide-induced up-regulation in endothelin-1 interferes with salivary mucin synthesis via epidermal growth factor receptor transactivation.
    IUBMB life, 2004, Volume: 56, Issue:10

    Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; ErbB Receptors; Lipopolysaccharides; Mucins; Oligopeptides; Porphyromonas gingivalis; Pyrimidines; Quinazolines; Rats; Saliva; Salivary Glands; src-Family Kinases; Time Factors; Transcriptional Activation; Trypan Blue; Up-Regulation

2004
Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Collagen; DNA; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Immunoprecipitation; Inflammation; NF-kappa B; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Oligonucleotide Probes; Phosphorylation; Polymerase Chain Reaction; Quinazolines; RNA; Tyrosine; Up-Regulation; Uterine Cervical Neoplasms

2005
The selective epidermal growth factor receptor tyrosine kinase inhibitor PD153035 suppresses expression of prometastasis phenotypes in malignant pleural mesothelioma cells in vitro.
    The Journal of thoracic and cardiovascular surgery, 2005, Volume: 129, Issue:5

    Topics: Antineoplastic Agents; Cell Movement; Cell Proliferation; Cocarcinogenesis; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Neoplastic; Humans; Laminin; Mesothelioma; Neoplasm Invasiveness; Neoplasm Metastasis; Phenotype; Pleural Neoplasms; Proteoglycans; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tumor Stem Cell Assay; Vascular Endothelial Growth Factor A

2005
Autocrine regulation of human urothelial cell proliferation and migration during regenerative responses in vitro.
    Experimental cell research, 2005, May-15, Volume: 306, Issue:1

    Topics: Amphiregulin; Antibodies; Autocrine Communication; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Gene Expression; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Quinazolines; Regeneration; Transforming Growth Factor alpha; Urothelium; Wound Healing

2005
Comparison of ELISA-based tyrosine kinase assays for screening EGFR inhibitors.
    Journal of receptor and signal transduction research, 2005, Volume: 25, Issue:1

    Topics: Animals; Baculoviridae; Cell Line; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Humans; In Vitro Techniques; Kinetics; Peptides; Quinazolines; Recombinant Proteins; Reproducibility of Results; Spodoptera; Substrate Specificity; Transfection

2005
Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.
    International journal of oncology, 2005, Volume: 27, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Resistance, Neoplasm; Drug Synergism; Embryo, Mammalian; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Inhibitor of Apoptosis Proteins; Keratinocytes; Melanoma; Mice; Mice, Knockout; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Proteins; Pentacyclic Triterpenes; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Survivin; Time Factors; Triterpenes

2005
Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin.
    The Journal of investigative dermatology, 2005, Volume: 125, Issue:3

    Topics: Anti-Bacterial Agents; Cells, Cultured; Chemokine CCL17; Chemokines, CC; ErbB Receptors; Humans; Interferon-gamma; Keratinocytes; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Quinazolines; Roxithromycin; Sesquiterpenes; Signal Transduction; Sulfones; Tumor Necrosis Factor-alpha

2005
Up-regulation in endothelin-1 by Helicobacter pylori lipopolysaccharide interferes with gastric mucin synthesis via epidermal growth factor receptor transactivation.
    Scandinavian journal of gastroenterology, 2005, Volume: 40, Issue:8

    Topics: Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Inhibitors; ErbB Receptors; Gastric Mucins; Gastric Mucosa; Helicobacter pylori; In Vitro Techniques; Lipopolysaccharides; Metalloendopeptidases; Quinazolines; Rats; Rats, Sprague-Dawley; Transcriptional Activation; Up-Regulation

2005
Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons.
    Molecular and cellular neurosciences, 2006, Volume: 31, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Electrophysiology; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; gamma-Aminobutyric Acid; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ligands; Neurons; Protein Subunits; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Transforming Growth Factor alpha

2006
The epidermal growth factor receptor (EGFR)-S442F mutant displays increased affinity for neuregulin-2beta and agonist-independent coupling with downstream signalling events.
    The Biochemical journal, 2006, May-15, Volume: 396, Issue:1

    Topics: Amino Acid Substitution; Animals; Apoptosis; Binding Sites; Cell Line; Chromones; Epidermal Growth Factor; ErbB Receptors; Genes, erbB-1; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Mice; Morpholines; Mutation, Missense; Myeloid Cells; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphorylation; Point Mutation; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quinazolines; Recombinant Fusion Proteins; Signal Transduction; Transfection

2006
Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment.
    Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:5

    Topics: Adenosine Triphosphate; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 7; Caspase Inhibitors; Caspases; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; ErbB Receptors; Estrogen Antagonists; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Indoles; Quinazolines; Time Factors

2006
COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer.
    British journal of cancer, 2006, Apr-24, Volume: 94, Issue:8

    Topics: Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Down-Regulation; Enzyme Activation; Female; Glycoproteins; Humans; Imidazoles; Lymphangiogenesis; Molecular Sequence Data; Pyrazoles; Pyridines; Pyrimidines; Quinazolines; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; RNA, Small Interfering; Structure-Activity Relationship; Vascular Endothelial Growth Factor C; Vesicular Transport Proteins

2006
PPARgamma-regulated tight junction development during human urothelial cytodifferentiation.
    Journal of cellular physiology, 2006, Volume: 208, Issue:2

    Topics: Anilides; Benzamides; Calcium; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Claudin-1; Claudin-3; Claudin-4; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Membrane Proteins; Phosphoproteins; PPAR gamma; Proteasome Endopeptidase Complex; Pyridines; Quinazolines; Thiazolidinediones; Tight Junctions; Ureter; Urothelium; Zonula Occludens-1 Protein

2006
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts.
    Cellular signalling, 2006, Volume: 18, Issue:12

    Topics: Arachidonic Acid; Blotting, Western; Cells, Cultured; Child; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Imidazoles; Indoles; Interleukin-1beta; Intramolecular Oxidoreductases; Maleimides; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Prostaglandin D2; Prostaglandin-E Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha

2006
Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells.
    International journal of oncology, 2006, Volume: 29, Issue:1

    Topics: Acetylation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Morpholines; Neoplasm Proteins; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Survivin; Time Factors

2006
Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.
    Cancer research, 2006, Jun-15, Volume: 66, Issue:12

    Topics: Aged; Amphiregulin; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Line, Tumor; Cell Transformation, Neoplastic; EGF Family of Proteins; ErbB Receptors; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Quinazolines; RNA, Small Interfering; Signal Transduction; Up-Regulation

2006
Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma.
    Cancer letters, 2007, Apr-08, Volume: 248, Issue:1

    Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines

2007
UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway.
    International journal of molecular medicine, 2006, Volume: 18, Issue:4

    Topics: Androstadienes; Blotting, Western; Cell Line; Chromones; Dose-Response Relationship, Radiation; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Keratinocytes; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Tumor Suppressor Proteins; Ultraviolet Rays; Vascular Endothelial Growth Factor A; Wortmannin

2006
EGF receptor clustering is induced by a 0.4 mT power frequency magnetic field and blocked by the EGF receptor tyrosine kinase inhibitor PD153035.
    Bioelectromagnetics, 2007, Volume: 28, Issue:3

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; Electromagnetic Fields; ErbB Receptors; Flow Cytometry; Microscopy, Atomic Force; Microscopy, Confocal; Microscopy, Electron, Transmission; Quinazolines

2007
Control of tight junctional sealing: role of epidermal growth factor.
    American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:2

    Topics: Adolescent; Adult; Animals; Cell Membrane Permeability; Cells, Cultured; Claudin-1; Claudin-4; Dogs; Electric Impedance; Epidermal Growth Factor; ErbB Receptors; Humans; Male; Membrane Proteins; Quinazolines; Tight Junctions

2007
The tyrosine kinase inhibitor PD153035: implication of labeling position on radiometabolites formed in vitro.
    Nuclear medicine and biology, 2006, Volume: 33, Issue:8

    Topics: Animals; Carbon Radioisotopes; ErbB Receptors; Humans; Isotope Labeling; Male; Protein Kinase Inhibitors; Quinazolines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Species Specificity

2006
Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:1

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Carcinoma, Renal Cell; Cell Cycle; Cell Death; Cell Survival; Drug Administration Schedule; Drug Synergism; ErbB Receptors; Inhibitory Concentration 50; Kidney Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; Quinazolines

2007
Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.
    Journal of cellular physiology, 2007, Volume: 211, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; CpG Islands; DNA Methylation; Enzyme Inhibitors; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Quinazolines; Receptors, Retinoic Acid; RNA Processing, Post-Transcriptional; Transcription, Genetic; Tyrphostins; Up-Regulation

2007
Protein C is an autocrine growth factor for human skin keratinocytes.
    The Journal of biological chemistry, 2007, May-04, Volume: 282, Issue:18

    Topics: Antibodies, Monoclonal; Antigens, CD; Autocrine Communication; Blood Coagulation; Cell Proliferation; Cells, Cultured; Endothelial Protein C Receptor; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Humans; Inflammation; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein C; Quinazolines; Receptors, Cell Surface; RNA, Small Interfering; Skin; Wound Healing

2007
Epidermal growth factor-, transforming growth factor-beta-, retinoic acid- and 1,25-dihydroxyvitamin D3-regulated expression of the novel protein PTPIP51 in keratinocytes.
    Cells, tissues, organs, 2006, Volume: 184, Issue:2

    Topics: Calcitriol; Cell Line; Cell Nucleus; Cytoplasm; Epidermal Growth Factor; Gene Expression Regulation; Humans; Keratinocytes; Mitochondrial Proteins; Protein Tyrosine Phosphatases; Quinazolines; RNA, Messenger; Transforming Growth Factor beta; Tretinoin

2006
Immortalization of human urothelial cells by human papillomavirus type 16 E6 and E7 genes in a defined serum-free system.
    Cell proliferation, 2007, Volume: 40, Issue:2

    Topics: Animals; Cell Cycle; Cell Growth Processes; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Clone Cells; Culture Media, Serum-Free; Epidermal Growth Factor; ErbB Receptors; Genes, Viral; Human papillomavirus 16; Humans; Karyotyping; Keratins; Mice; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Papillomavirus Infections; Phenotype; Quinazolines; Repressor Proteins; Telomerase; Urothelium

2007
[Expressions of epidermal growth factor receptor signaling substances in gastric mucosal cells influenced by serum derived from rats treated with electroacupuncture at stomach meridian acupoints].
    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2007, Volume: 5, Issue:3

    Topics: Acupuncture Points; Animals; Electroacupuncture; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Female; Gastric Mucosa; Gene Expression; Male; Phospholipase C gamma; Protein Kinase C; Proto-Oncogene Proteins c-myc; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Restraint, Physical; Reverse Transcriptase Polymerase Chain Reaction; Serum; Signal Transduction; Stomach Diseases

2007
The DNA-binding epidermal growth factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-beta tumor-suppressor gene in breast cancer cells.
    Differentiation; research in biological diversity, 2007, Volume: 75, Issue:9

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; DNA; ErbB Receptors; Genes, Tumor Suppressor; Humans; Intercalating Agents; Protein Kinase Inhibitors; Quinazolines; Receptors, Retinoic Acid; Up-Regulation

2007
Further characterization of the epidermal growth factor receptor ligand 11C-PD153035.
    Chinese medical journal, 2007, Jun-05, Volume: 120, Issue:11

    Topics: Animals; Carbon Radioisotopes; Cell Line, Tumor; ErbB Receptors; Female; Humans; Ligands; Mice; Mice, Inbred BALB C; Mice, Nude; Positron-Emission Tomography; Quinazolines

2007
Assessment of 11C-labeled-4-N-(3-bromoanilino)-6,7-dimethoxyquinazoline as a positron emission tomography agent to monitor epidermal growth factor receptor expression.
    Cancer science, 2007, Volume: 98, Issue:9

    Topics: Animals; Biomarkers, Tumor; Carbon Radioisotopes; Cell Line, Tumor; ErbB Receptors; Female; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Organ Specificity; Positron-Emission Tomography; Quinazolines

2007
Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages.
    Experimental & molecular medicine, 2007, Aug-31, Volume: 39, Issue:4

    Topics: Animals; Benzoflavones; Cell Differentiation; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Genistein; Hazardous Substances; Humans; Macrophages; MAP Kinase Signaling System; Mice; Phosphorylation; Polychlorinated Dibenzodioxins; Pyrimidines; Quinazolines; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; src-Family Kinases; Tumor Necrosis Factor-alpha

2007
Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs.
    Cancer letters, 2008, Aug-08, Volume: 266, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; Mice; Ovarian Neoplasms; Paclitaxel; Protein Kinase Inhibitors; Quinazolines; Signal Transduction

2008
Antitumor activity of a novel EGFR tyrosine kinase inhibitor against human lung carcinoma in vitro and in vivo.
    Investigational new drugs, 2009, Volume: 27, Issue:1

    Topics: Adenocarcinoma; Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinazolines; Xenograft Model Antitumor Assays

2009
Biochemical assay-based selectivity profiling of clinically relevant kinase inhibitors on mutant forms of EGF receptor.
    Journal of receptor and signal transduction research, 2008, Volume: 28, Issue:3

    Topics: Aminoquinolines; Aniline Compounds; Biological Assay; Drug Resistance; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Inhibitory Concentration 50; Morpholines; Mutant Proteins; Protein Kinase Inhibitors; Quinazolines; Substrate Specificity; Tyrphostins

2008
HTS assays using a disease-relevant cell model for interrogating the MAP kinase pathway initiated by multiple receptors.
    Assay and drug development technologies, 2008, Volume: 6, Issue:3

    Topics: Cell Line, Tumor; Epidermal Growth Factor; Female; Hepatocyte Growth Factor; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Proto-Oncogene Proteins; Quinazolines; Receptors, Cell Surface

2008
[Molecular imaging of epidermal growth factor receptor in glioma-bearing rats].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2008, Volume: 30, Issue:5

    Topics: Animals; Brain Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; ErbB Receptors; Gastrointestinal Tract; Glioma; Liver; Male; Neoplasm Transplantation; Positron-Emission Tomography; Quinazolines; Rats; Rats, Wistar; Tissue Distribution; Tomography, X-Ray Computed

2008
Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor.
    British journal of biomedical science, 2008, Volume: 65, Issue:3

    Topics: Adenocarcinoma; Amphiregulin; Autoantibodies; Cell Line, Tumor; Cell Proliferation; EGF Family of Proteins; ErbB Receptors; Esophageal Neoplasms; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Leptin; Matrix Metalloproteinases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Transforming Growth Factor alpha; Tyrphostins

2008
Growth factors involved in aqueous humour-induced lens cell proliferation.
    Growth factors (Chur, Switzerland), 2009, Volume: 27, Issue:1

    Topics: Animals; Aqueous Humor; Cell Proliferation; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; Fibroblast Growth Factors; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Lens, Crystalline; Platelet-Derived Growth Factor; Pyrroles; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tyrphostins

2009
Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling.
    Toxicology and applied pharmacology, 2009, Mar-01, Volume: 235, Issue:2

    Topics: Blotting, Western; Butyrates; Cell Line, Tumor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Genes, ras; Humans; Immunoprecipitation; Indoles; Organometallic Compounds; Phenols; Phosphorylation; Protein Kinase C-alpha; Quinazolines; raf Kinases; Receptors, Platelet-Derived Growth Factor; src-Family Kinases; Sulfonamides; Transfection

2009
B5, a novel pyrrole-substituted indolinone, exerts potent antitumor efficacy through G2/M cell cycle arrest.
    Investigational new drugs, 2010, Volume: 28, Issue:1

    Topics: Antineoplastic Agents; Bromodeoxyuridine; CDC2 Protein Kinase; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin B1; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; G2 Phase; Humans; Imidazoles; Indoles; Mitosis; Pyrroles; Quinazolines

2010
PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:2

    Topics: Adult; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Female; Humans; Ligands; Lung Neoplasms; Male; Metabolic Clearance Rate; Positron-Emission Tomography; Quinazolines; Radiometry; Radiopharmaceuticals; Tissue Distribution; Tomography, X-Ray Computed; Young Adult

2009
F84, a quinazoline derivative, exhibits high potent antitumor activity against human gynecologic malignancies.
    Investigational new drugs, 2010, Volume: 28, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; ErbB Receptors; Female; Genital Neoplasms, Female; Humans; Mice; Mitogen-Activated Protein Kinases; Organ Size; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Xenograft Model Antitumor Assays

2010
The unfolded protein response is activated in differentiating epidermal keratinocytes.
    The Journal of investigative dermatology, 2009, Volume: 129, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; ATP-Binding Cassette Transporters; Carcinoma, Squamous Cell; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; DNA-Binding Proteins; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Immunohistochemistry; Keratinocytes; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Middle Aged; Protein Disulfide-Isomerases; Protein Folding; Protein Transport; Psoriasis; Quinazolines; Regulatory Factor X Transcription Factors; RNA, Messenger; Signal Transduction; Transcription Factors; Ubiquitin-Protein Ligases; X-Box Binding Protein 1

2009
Molecular imaging of EGFR: it's time to go beyond receptor expression.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:7

    Topics: Adult; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Female; Humans; Ligands; Lung Neoplasms; Male; Metabolic Clearance Rate; Molecular Probe Techniques; Positron-Emission Tomography; Quinazolines; Radiometry; Radiopharmaceuticals; Tissue Distribution; Tomography, X-Ray Computed; Young Adult

2009
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
    Molecular and cellular biology, 2009, Volume: 29, Issue:20

    Topics: Anthracenes; Butadienes; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Imidazoles; Lactones; MAP Kinase Kinase Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Resorcinols; RNA, Small Interfering; Serine; Signal Transduction; Threonine; Tumor Necrosis Factor-alpha

2009
EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice.
    Diabetes, 2009, Volume: 58, Issue:12

    Topics: Adiponectin; Adipose Tissue; Animals; Blood Glucose; Dietary Fats; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Enzymologic; Glucose Tolerance Test; Hypoglycemic Agents; Immunoblotting; Immunoprecipitation; Inflammation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Leptin; Liver; Macrophages; Male; Mice; Muscle, Skeletal; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Tumor Necrosis Factor-alpha

2009
EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells.
    Biological chemistry, 2009, Volume: 390, Issue:12

    Topics: Amino Acid Sequence; Cell Line, Tumor; ErbB Receptors; Extracellular Matrix Proteins; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Pancreatic Neoplasms; Phosphorylation; Phylogeny; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Sequence Alignment

2009
Potent cardioprotective effect of the 4-anilinoquinazoline derivative PD153035: involvement of mitochondrial K(ATP) channel activation.
    PloS one, 2010, May-17, Volume: 5, Issue:5

    Topics: Adenosine Triphosphate; Animals; Biological Transport; Calcium; Cardiotonic Agents; Cell Respiration; Cyanides; Heart Function Tests; In Vitro Techniques; Ion Channel Gating; Male; Mice; Mitochondria; Myocardial Reperfusion Injury; Myocardium; Permeability; Phosphorylation; Potassium; Potassium Channels; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Wistar

2010
Synthesis and initial tumor affinity testing of iodine-123 labelled EGFR-affine agents as potential imaging probes for hormone-refractory prostate cancer.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:9

    Topics: Animals; Antibodies, Monoclonal; Biological Transport; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Gene Expression Regulation, Neoplastic; Hormones; Humans; Iodine Radioisotopes; Male; Mice; Molecular Imaging; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Radionuclide Imaging; Rats; Tomography; Xenograft Model Antitumor Assays

2010
Epidermal growth factor receptor tyrosine kinase inhibitors induce CCL2 and CCL5 via reduction in IL-1R2 in keratinocytes.
    Experimental dermatology, 2010, Volume: 19, Issue:8

    Topics: Acneiform Eruptions; Adolescent; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Cell Line; Enzyme Inhibitors; ErbB Receptors; Female; Gefitinib; Humans; Interleukin-1; Keratinocytes; Lung Neoplasms; Male; Middle Aged; Quinazolines; Receptors, Interleukin-1; Receptors, Interleukin-1 Type II; RNA, Messenger; Signal Transduction

2010
Gastrin-releasing peptide promotes the growth of HepG2 cells via EGFR-independent ERK1/2 activation.
    Oncology reports, 2010, Volume: 24, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Enzyme Activation; ErbB Receptors; Gastrin-Releasing Peptide; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Indoles; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Receptors, Bombesin

2010
Signaling through erbB receptors is a critical functional regulator in the mature cochlea.
    The European journal of neuroscience, 2010, Volume: 32, Issue:5

    Topics: Animals; Cell Count; Cochlea; Evoked Potentials, Auditory, Brain Stem; Female; Gene Expression; Guinea Pigs; Hair Cells, Auditory, Outer; Microinjections; Neurotrophin 3; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptors, Glutamate; Spiral Ganglion; Time Factors

2010
Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics.
    Journal of proteome research, 2010, Dec-03, Volume: 9, Issue:12

    Topics: Amyloid beta-Protein Precursor; Androstadienes; Antibodies, Monoclonal; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cystatin C; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; ErbB Receptors; Humans; Immunohistochemistry; Nasopharyngeal Neoplasms; Proteomics; Quinazolines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transforming Growth Factor alpha; Wortmannin

2010
Evaluation of radioiodinated quinazoline derivative as a new ligand for EGF receptor tyrosine kinase activity using SPECT.
    Annals of nuclear medicine, 2011, Volume: 25, Issue:2

    Topics: Animals; Cell Line, Tumor; ErbB Receptors; Humans; Iodine Radioisotopes; Ligands; Male; Mice; Neoplasms; Protein Kinase Inhibitors; Quinazolines; Substrate Specificity; Tomography, Emission-Computed, Single-Photon

2011
A novel hybrid peptide targeting EGFR-expressing cancers.
    European journal of cancer (Oxford, England : 1990), 2011, Volume: 47, Issue:5

    Topics: Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Mice; Mutant Chimeric Proteins; Neoplasm Transplantation; Neoplasms; Quinazolines; Receptor Protein-Tyrosine Kinases; Transplantation, Heterologous

2011
Determining the binding mode and binding affinity constant of tyrosine kinase inhibitor PD153035 to DNA using optical tweezers.
    Biochemical and biophysical research communications, 2011, Jan-07, Volume: 404, Issue:1

    Topics: Antineoplastic Agents; DNA; Humans; Intercalating Agents; Optical Tweezers; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Thermodynamics

2011
EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:7

    Topics: 3T3 Cells; Alkaline Phosphatase; Amphiregulin; Animals; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Genetic Markers; Glycoproteins; Heparin-binding EGF-like Growth Factor; Histone Deacetylase 6; Histone Deacetylases; Humans; Integrin-Binding Sialoprotein; Intercellular Signaling Peptides and Proteins; Mice; Neuregulin-1; Osteoblasts; Osteocalcin; Osteogenesis; Quinazolines; Signal Transduction; Sp7 Transcription Factor; Transcription Factors; Transcription, Genetic; Transforming Growth Factor alpha

2011
Molecular imaging with 11C-PD153035 PET/CT predicts survival in non-small cell lung cancer treated with EGFR-TKI: a pilot study.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:10

    Topics: Aged; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Pilot Projects; Positron-Emission Tomography; Prospective Studies; Protein Kinase Inhibitors; Quinazolines; Radiopharmaceuticals; Tomography, X-Ray Computed; Treatment Outcome

2011
Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.
    ChemMedChem, 2012, Volume: 7, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line; Cetuximab; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Multiple; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Morpholines; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Signal Transduction; Tyrphostins

2012
Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
    Journal of immunology (Baltimore, Md. : 1950), 2012, Apr-01, Volume: 188, Issue:7

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Becaplermin; Cell Division; Cyclooxygenase 2; Cytokines; Drug Evaluation, Preclinical; Endothelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Fibroblasts; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred DBA; Neovascularization, Pathologic; Osteoclasts; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Synovial Membrane

2012
Therapeutic and preventive effects of an epidermal growth factor receptor inhibitor on oral squamous cell carcinoma.
    The Journal of international medical research, 2012, Volume: 40, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cheek; Cricetinae; ErbB Receptors; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Quinazolines; STAT3 Transcription Factor; Xenograft Model Antitumor Assays

2012
Epidermal growth factor enhances MPC-83 pancreatic cancer cell migration through the upregulation of aquaporin 3.
    Molecular medicine reports, 2012, Volume: 6, Issue:3

    Topics: Antineoplastic Agents; Aquaporin 3; Butadienes; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Nitriles; Pancreatic Neoplasms; Phosphorylation; Quinazolines; Up-Regulation

2012
Gefitinib, but not erlotinib, is a possible inducer of Fra-1-mediated interstitial lung disease.
    The Keio journal of medicine, 2012, Volume: 61, Issue:4

    Topics: Animals; Antineoplastic Agents; Chemokine CCL2; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Gene Expression Regulation; Lipopolysaccharides; Lung Diseases, Interstitial; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Primary Cell Culture; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; Tumor Necrosis Factor-alpha

2012
ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions.
    Translational psychiatry, 2013, Apr-30, Volume: 3

    Topics: Animals; Antipsychotic Agents; Brain Chemistry; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Male; Motor Activity; Quinazolines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Schizophrenic Psychology

2013
Sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor requires E-cadherin in esophageal cancer and malignant pleural mesothelioma.
    Anticancer research, 2013, Volume: 33, Issue:6

    Topics: Biomarkers, Tumor; Cadherins; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; ErbB Receptors; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Quinazolines; Signal Transduction

2013
Dynamic conformational transitions of the EGF receptor in living mammalian cells determined by FRET and fluorescence lifetime imaging microscopy.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2013, Volume: 83, Issue:9

    Topics: Animals; Cell Membrane; CHO Cells; Cricetulus; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Models, Molecular; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins

2013
Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:10

    Topics: Animals; Biological Transport; Carbon Radioisotopes; Cell Line, Tumor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Probes; Positron-Emission Tomography; Quinazolines; Rats; Rats, Sprague-Dawley; Tissue Distribution

2013
Pb²⁺ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells.
    Environmental toxicology, 2015, Volume: 30, Issue:3

    Topics: Cell Line, Tumor; Environmental Pollutants; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Interleukin-8; Lead; Proto-Oncogene Proteins c-jun; Quinazolines; Stomach Neoplasms; Transcription Factor AP-1; Tyrphostins; Up-Regulation

2015
Combined treatment with sodium butyrate and PD153035 enhances keratinocyte differentiation.
    Experimental dermatology, 2014, Volume: 23, Issue:3

    Topics: Antineoplastic Agents; Butyric Acid; Cell Differentiation; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Filaggrin Proteins; Histamine Antagonists; Humans; Intermediate Filament Proteins; Keratinocytes; Quinazolines; RNA, Messenger; Transglutaminases

2014
Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells.
    Scientific reports, 2014, Feb-05, Volume: 4

    Topics: Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Neoplasms; Nitro Compounds; Oxadiazoles; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins

2014
Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells.
    Molecules (Basel, Switzerland), 2015, May-28, Volume: 20, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Epithelial Cells; ErbB Receptors; Female; Gene Expression; Humans; Mammary Glands, Human; Mitochondria; Plasminogen Inactivators; Quinazolines; Reactive Oxygen Species; Urokinase-Type Plasminogen Activator

2015
Relevance of E-cadherin expression to EGFR-TKI molecular targeted therapy sensitivity/resistance and its clinical significance.
    Genetics and molecular research : GMR, 2015, May-29, Volume: 14, Issue:2

    Topics: Breast Neoplasms; Cadherins; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Molecular Targeted Therapy; Protein Kinase Inhibitors; Quinazolines; Signal Transduction

2015
Predictive efficacy of (11)C-PD153035 PET imaging for EGFR-tyrosine kinase inhibitor sensitivity in non-small cell lung cancer patients.
    International journal of cancer, 2016, Feb-15, Volume: 138, Issue:4

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; Drug Resistance, Neoplasm; ErbB Receptors; Heterografts; Humans; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Nude; Multimodal Imaging; Positron-Emission Tomography; Protein Kinase Inhibitors; Quinazolines; Tomography, X-Ray Computed

2016
Role of EGF receptor ligands in TCDD-induced EGFR down-regulation and cellular proliferation.
    Chemico-biological interactions, 2016, Jun-25, Volume: 253

    Topics: Amphiregulin; Cell Proliferation; Cells, Cultured; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Ligands; Polychlorinated Dibenzodioxins; Protein Binding; Quinazolines; Transforming Growth Factor alpha

2016
Activation of AMP-activated kinase modulates sensitivity of glioma cells against epidermal growth factor receptor inhibition.
    International journal of oncology, 2016, Volume: 49, Issue:1

    Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Glioma; Glucose; Glycolysis; Humans; Imatinib Mesylate; K562 Cells; Phosphorylation; Pyrones; Quinazolines; Thiophenes

2016
Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo.
    Cancer letters, 2018, 06-28, Volume: 424

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Mice; Neoplasm Proteins; Quinazolines; Topotecan; Up-Regulation; Xenograft Model Antitumor Assays

2018
Transcriptional repressor Kaiso promotes epithelial to mesenchymal transition and metastasis in prostate cancer through direct regulation of miR-200c.
    Cancer letters, 2018, 09-01, Volume: 431

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Epidermal Growth Factor; Epithelial-Mesenchymal Transition; ErbB Receptors; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Neoplasm Transplantation; Prostatic Neoplasms; Quinazolines; Transcription Factors

2018
ERK1/2-mediated EGFR-signaling is required for TGFβ-induced lens epithelial-mesenchymal transition.
    Experimental eye research, 2019, Volume: 178

    Topics: Actins; Animals; beta Catenin; Blotting, Western; Cell Movement; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Lens, Crystalline; MAP Kinase Signaling System; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta2

2019
Weak power frequency magnetic fields induce microtubule cytoskeleton reorganization depending on the epidermal growth factor receptor and the calcium related signaling.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: Calcium; Calcium Channels, L-Type; Calcium Signaling; Cell Line; Electromagnetic Fields; Enzyme Inhibitors; ErbB Receptors; Humans; Intracellular Space; Microtubules; Phosphorylation; Quinazolines

2018
Epidermal growth factor receptor inhibition attenuates non-alcoholic fatty liver disease in diet-induced obese mice.
    PloS one, 2019, Volume: 14, Issue:2

    Topics: Animals; Cell Line, Tumor; Diabetes Mellitus, Experimental; Dietary Fats; ErbB Receptors; Humans; Lipogenesis; Male; Mice; Non-alcoholic Fatty Liver Disease; Quinazolines; Signal Transduction

2019
Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium.
    Scientific reports, 2019, 07-19, Volume: 9, Issue:1

    Topics: CDX2 Transcription Factor; Cell Differentiation; Cells, Cultured; Dextrans; Endoderm; ErbB Receptors; Fibroblast Growth Factor 10; Fluorescein-5-isothiocyanate; Glycogen Synthase Kinase 3 beta; Humans; Induced Pluripotent Stem Cells; Permeability; PPAR gamma; Pyridines; Pyrimidines; Quinazolines; Recombinant Proteins; Regenerative Medicine; SOXF Transcription Factors; Troglitazone; Urinary Bladder; Uroplakins; Urothelium

2019
Scratch wound-induced CXCL8 upregulation is EGFR-dependent in keratinocytes.
    Journal of dermatological science, 2020, Volume: 99, Issue:3

    Topics: Cell Movement; Cells, Cultured; ErbB Receptors; Humans; Interleukin-8; Keratinocytes; Quinazolines; Up-Regulation; Wound Healing

2020
Activation of PPARγ and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells.
    PloS one, 2020, Volume: 15, Issue:8

    Topics: Animals; Arsenites; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Down-Regulation; ErbB Receptors; Hepatocyte Nuclear Factor 3-alpha; Humans; Keratins; Mice; Mice, Nude; PPAR gamma; Quinazolines; Transcription Factors; Transcriptome; Transplantation, Heterologous; Troglitazone; Up-Regulation; Urinary Bladder Neoplasms

2020