quinazolines has been researched along with pd 153035 in 163 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (0.61) | 18.7374 |
1990's | 24 (14.72) | 18.2507 |
2000's | 98 (60.12) | 29.6817 |
2010's | 38 (23.31) | 24.3611 |
2020's | 2 (1.23) | 2.80 |
Authors | Studies |
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Bridges, AJ; Cody, DR; Denny, WA; Fry, DW; McMichael, A; Palmer, BD; Rewcastle, GW; Thompson, AM; Zhou, H | 1 |
Ambroso, LA; Bridges, AJ; Connors, RW; Fry, DW; Kraker, AJ; Leopold, WR; McMichael, A; Nelson, JM | 1 |
Bridges, AJ; Cody, DR; Denny, WA; Fry, DW; Kraker, AJ; McMichael, A; Rewcastle, GW; Showalter, HD; Zhou, H | 1 |
Elliott, WL; Hook, KE; Howard, CT; Kunkel, MW; Leopold, WR; Przybranowski, S; Roberts, BJ | 1 |
Hollenberg, MD; Zheng, XL | 1 |
Fridman, R; Kondapaka, SB; Reddy, KB | 1 |
Borgers, S; Hagmann, W | 1 |
Fry, DW; Nelson, JM | 1 |
Coffey, RJ; Der, CJ; Gangarosa, LM; Graves-Deal, R; Oldham, SM; Sizemore, N | 1 |
Elder, J; Garner, W; Stoll, S | 1 |
Hamacher, L; Peus, D; Pittelkow, MR | 1 |
Hollenberg, MD; Renaux, B; Zheng, XL | 1 |
Adjei, PN; Glenn, KS; Gores, GJ; Karnes, WE; Kaufmann, SH; Kottke, TJ; Weller, SG | 1 |
Earp, HS; Graves, LM; Lee, JW; Li, X | 1 |
Benedict, M; Elder, JT; Hiniker, A; Mitra, R; Nuñez, G; Stoll, SW | 1 |
Kumar, R; Singh, P | 1 |
Affleck, K; Dean, C; Modjtahedi, H; Stubberfield, C | 1 |
Albanell, J; Baselga, J; Bos, M; Fry, DW; Kim, YM; Mendelsohn, J | 1 |
Dumin, J; Mast, BA; Parks, WC; Pilcher, BK; Schultz, GS; Schwartz, MJ; Welgus, HG | 1 |
Ahola, H; Carlstedt-Duke, J; Modéer, T; Yucel-Lindberg, T | 1 |
Damjanovich, S; Jenei, A; Jovin, TM; Kirsch, AK; Nagy, P; Szöllosi, J | 1 |
Borgström, P; Eksborg, S; Fredriksson, A; Hassan, M; Ingvar, M; Johnström, P; Kogner, P; Stone-Elander, S; Thorell, JO; von Heijne, G | 1 |
Greenberg, NM; Kassis, J; Kim, HG; Lo, H; Moellinger, J; Wells, A | 1 |
Ahmed, K; Davis, AT; Faust, RA; Tawfic, S | 1 |
Blaudschun, R; Brenneisen, P; Meewes, C; Scharffetter-Kochanek, K; Wlaschek, M | 1 |
Beyerle, A; Meves, A; Peus, D; Pittelkow, MR; Vasa, RA | 1 |
Balmain, A; Beug, H; Oft, M; Petritsch, C | 1 |
Chen, F; Ireland, ME; Mrock, LK | 1 |
Brychzy, A; de Paulsen, N; Fournier, MC; Gnarra, JR; Klausner, RD; Lee, S; Pause, A | 1 |
Egeblad, M; Jäättelä, M; Mortensen, OH; van Kempen, LC | 1 |
Belt, A; Fisher, G; Voorhees, J; Wan, Y; Wang, Z | 1 |
Fisher, G; Voorhees, J; Wan, YS; Wang, ZQ | 1 |
Diao, C; Hollenberg, MD; Matsubara, S; Wong, NC; Zheng, XL | 1 |
Bailly, C; Baldeyrou, B; Bouey-Bencteux, E; Colson, P; Goossens, JF; Hénichart, JP; Houssier, C; Houssin, R; Laine, W | 1 |
Klar, U; Lichtner, RB; Menrad, A; Schneider, MR; Sommer, A | 1 |
Bennett, TA; Bergmann-Leitner, ES; Hacker, NF; Stetler-Stevenson, WG; Stromberg, K | 1 |
Bode, AM; Chen, N; Dong, Z; Liu, G; Ma, WY; She, QB; Wu, E | 1 |
Bulloch, AG; Hermann, PM; Wildering, WC | 1 |
Chung, HK; Lee, JY; Lee, SJ; Lee, YS; Park, H; Park, YK; Seo, SH; So, IS; Yang, BS | 1 |
Li, L; Shaw, PE | 1 |
Baatar, D; Pai, R; Pavelka, M; Soreghan, B; Szabo, IL; Tarnawski, AS | 1 |
Bode, AM; Chen, N; Dong, Z; Ma, WY; Zhang, Y | 1 |
Graves, LM; Jaspers, I; Samet, JM; Wu, W; Zhang, W | 1 |
Iimuro, Y; Kawada, N; Okuyama, H; Seki, S; Shimahara, Y; Uyama, N; Yamaoka, Y | 1 |
Barrie, E; Kelland, LR; Rowlands, MG; Smith, V; Workman, P | 1 |
Meves, A; Peus, D; Pittelkow, MR | 1 |
Kassis, J; Klein, G; Maeda, A; Takada, K; Teramoto, N; Wells, A; Wu, C | 1 |
Park, SY; Seol, DW | 1 |
Boschelli, DH | 1 |
Katoh, O; Lu, H; Uesaka, T; Watanabe, H | 1 |
Buresi, MC; Buret, AG; Hollenberg, MD; MacNaughton, WK | 1 |
Feng, C; Grandis, JR; Li, M; Liu, X; Riedel, F; Ye, C; Zeng, Q | 1 |
Chatziantoniou, C; Coffman, T; Dussaule, JC; Flamant, M; Henrion, D; Placier, S; Tharaux, PL | 1 |
Blencke, S; Daub, H; Ullrich, A | 1 |
Brock, R; Jovin, TM | 1 |
Li, J; Majumdar, AP; Xiao, ZQ | 1 |
Fredriksson, A; Stone-Elander, S | 1 |
Hénichart, JP; Mimeault, M; Pommery, N | 1 |
Conzen, SD; Coticchia, CM; Dickson, RB; Nishanian, TG; Ramljak, D; Ringel, MD; Saji, M | 1 |
Dewar, BJ; Graves, LM; Samet, JM; Wu, W | 1 |
Hidaka, K; Morisaki, T; Suk Kim, H | 1 |
Bromberg, PA; Dailey, LA; Graves, LM; Samet, JM; Sheppard, D; Silbajoris, R; Wu, W | 1 |
RYE, RM; WISEMAN, D | 1 |
Chang, CM; Li, B; McKenna, WG; Shu, HK; Yuan, M | 1 |
Bader, B; Glienke, J; Sturz, A; Thierauch, KH | 1 |
Lippman, ME; Rae, JM | 1 |
Chansel, D; Chatziantoniou, C; Dussaule, JC; Flamant, M; François, H; Placier, S; Tharaux, PL | 1 |
Diggle, C; Holder, J; Lee, WC; Selby, PJ; Southgate, J; Stahlschmidt, J; Trejdosiewicz, LK; Varley, CL | 1 |
Cho, YM; Foley, J; Gocken, TA; Koltz, PF; Konger, RL; Lewis, DA; Richard, V; Rosol, TJ; Spandau, DF | 1 |
Slomiany, A; Slomiany, BL | 3 |
Smith, B; Southgate, J; Stahlschmidt, J; Stower, M; Varley, CL | 1 |
Eisenmann, C; Klumpp, A; Steinbach, JP; Weller, M | 1 |
He, XY; Huang, JA; Jiang, LY; Wang, YD; Xie, W | 1 |
Bazan, HE; Bazan, NG; Ottino, P; Sharma, GD | 1 |
Baumgarten, CM; Ren, Z | 1 |
de Arruda Rolim Filho, L; Franchini, KG; Marin, RM; Rittner, R; Rocco, SA; Velho, JA; Vercesi, AE | 1 |
Dai, JR; Deretey, E; Foster, JE; Ng, W; Pasternak, A; Redden, PR; Reid, N; Slon-Usakiewicz, JJ; Toledo-Sherman, L | 1 |
Gaiger, A; Grunt, TW; Kainz, B; Puckmair, K; Tomek, K | 1 |
Allen, S; Marker, D; Michael, E; Nees, M; Smith, L; Woodworth, CD | 1 |
Alleva, AM; Cole, GW; Maxhimer, JB; Nguyen, DM; Reddy, RM; Schrump, DS; Zuo, J | 1 |
Hill, G; Pellegrin, S; Selby, PJ; Shaw, NJ; Southgate, J; Trejdosiewicz, LK; Varley, C | 1 |
Bökönyi, G; Gyökeres, T; Keri, G; Orfi, L; Pap, A; Petak, I; Schäfer, E; Schwab, R; Szokoloczi, O; Varkondi, E | 1 |
Derby, S; Di, W; Jiang, Q; Qiu, L; Schefeller, E; Wan, Y; Wanebo, H; Wang, Q; Yan, B | 1 |
Hanakawa, Y; Hashimoto, K; Kagami, S; Kakinuma, T; Komine, M; Tamaki, K | 1 |
Iwakura, Y; Jourdi, H; Nagano, T; Namba, H; Nawa, H; Takei, N; Xiong, H | 1 |
Gallo, RM; Gilmore, JL; Riese, DJ | 1 |
Fox, LH; Howells, LM; Manson, MM; Moiseeva, EP; Temple, LA | 1 |
Chakraborty, C; Lala, PK; Timoshenko, AV; Wagner, GF | 1 |
Cross, W; Garthwaite, MA; Hinley, J; Southgate, J; Trejdosiewicz, LK; Varley, CL | 1 |
Kawakami, T; Olsson, T; Yucel-Lindberg, T | 1 |
Di, W; Healey, S; Kouttab, N; Qiu, L; Sun, Y; Wan, Y; Wanebo, H; Yan, B; Zhou, C | 1 |
Avila, MA; Berasain, C; Castillo, J; Erroba, E; Lee, DC; Perugorría, MJ; Prieto, J; Santamaría, M | 1 |
Chen, H; Fan, ST; Kok, TW; Liu, Y; Poon, RT; Shao, W; Sun, X | 1 |
Bi, Z; Li, Y; Wan, Y; Yan, B | 1 |
Chen, S; Jia, C; Liu, R; Xia, R; Zhou, Z | 1 |
Cereijido, M; Contreras, RG; Flores-Benítez, D; Flores-Maldonado, C; Ruiz-Cabrera, A; Shoshani, L | 1 |
Fredriksson, A; Samén, E; Stone-Elander, S; Thorell, JO | 1 |
An, J; Rettig, MB | 1 |
Gaiger, A; Grunt, TW; Kainz, B; Köhler, G; Puckmair, K; Rünzler, D; Tomek, K; Wagner, R; Zielinski, CC | 1 |
Campbell, D; Jackson, CJ; Xue, M | 1 |
Hofer, HW; Pfeiffer, T; Schreiner, D; Stenzinger, A; Tag, C; Wimmer, M | 1 |
Bassuk, JA; Carmean, N; Hudson, AE; Kosman, JW; Leaf, EM; Opheim, KE | 1 |
Chang, XR; Lin, YP; Yan, J; Yang, ZB; Yi, SX; Zhong, Y | 1 |
Grunt, TW; Puckmair, K; Tomek, K; Wagner, R; Zielinski, CC | 1 |
Song, XR; Sun, XR; Wang, H; Wang, XW; Yang, GR; Yu, JM; Zhao, SQ; Zhao, W | 1 |
Mu, D; Song, X; Sun, X; Wang, H; Yang, G; Yu, J; Zhao, S | 1 |
Cheon, H; Cho, S; Kim, HJ; Kim, HS; Lee, JY; Sohn, J; Won, NH; Woo, YS | 1 |
Amaral, A; Cao, C; Chu, W; Di, W; Kivlin, R; Lu, S; Sowa, A; Wan, Y; Yang, H | 1 |
Cai, H; Duan, W; Fu, L; Jiang, H; Li, L; Mei, C; Wang, L; Xiong, X | 1 |
Breza, N; Keri, G; Orfi, L; Petak, I; Pinter, F; Robert, K; Schwab, R; Varkondi, E | 1 |
Bi, K; Echeverria, VM; Honer, J; Machleidt, T; Vandenheuvel-Kramer, K; Wilkinson, JM; Zhong, Z | 1 |
Fu, Z; Liu, YL; Mu, DB; Song, B; Song, XR; Teng, XP; Wang, H; Wang, XW; Wei, L; Yang, GR; Yu, JM; Zhao, SQ | 1 |
Beales, IL; Ogunwobi, OO | 1 |
Iyengar, L; Lovicu, FJ; McAvoy, JW; Patkunanathan, B | 1 |
Tzeng, DW; Wang, CY; Wang, YT; Yang, JL | 1 |
Dong, Z; Fu, L; Gao, X; Ji, C; Li, L; Liu, H; Luo, X; Mei, C; Xiong, X; Zhang, Y | 1 |
Fu, Z; Li, M; Li, X; Liu, N; Ma, L; Meng, X; Yang, G; Yang, Y; Yu, J; Zhao, S | 1 |
Chen, XG; Feng, ZQ; Li, J; Liu, Y; Meng, Y | 1 |
Futamura, K; Hashimoto, N; Matsumoto, K; Muro, Y; Nagasaka, T; Nishizawa, Y; Saito, H; Sugiura, K; Tomita, Y; Usukura, J | 1 |
Biasco, G; Boschi, S; Fanti, S; Lollini, PL; Nannini, M; Pantaleo, MA | 1 |
Kawanishi, M; Koizumi, K; Nishimura, M; Saiki, I; Sakurai, H; Shin, MS; Singhirunnusorn, P; Suzuki, S | 1 |
Carvalheira, JB; Cintra, DE; de Souza, CT; Franchini, KG; Mourão, RH; Pauli, JR; Prada, PO; Rittner, R; Rocco, SA; Ropelle, ER; Saad, MJ; Schenka, A; Vassallo, J; Velloso, LA | 1 |
Blum, H; Bruns, CJ; Camaj, P; De Toni, EN; Faktorova, D; Ischenko, I; Jauch, KW; Krebs, S; Seeliger, H | 1 |
Castilho, RF; Cavalheiro, RA; Cerqueira, FM; da Silva, CC; Franchini, KG; Kowaltowski, AJ; Marin, RM; Rittner, R; Rocco, SA; Vercesi, AE | 1 |
Fozing, T; Samnick, S; Scheuer, C | 1 |
Muro, Y; Shimoyama, Y; Sugiura, K; Tomita, Y; Yamaki, M | 1 |
Li, X; Li, Z; Lv, Y; Ma, Y; Yi, S; Yuan, A | 1 |
Fridberger, A; Gont, C; Kirkegaard, M; Mannström, P; Matsumoto, S; Ulfendahl, M; Watanabe, F | 1 |
Chen, ZC; Guan, YJ; Li, C; Li, MY; Li, XH; Liang, K; Peng, F; Tang, CE; Xiao, ZQ; Yao, KT; Yi, B; Yi, H; Zhang, PF; Zou, HY | 1 |
Hirata, M; Kagawa, S; Kanai, Y; Matsumuro, K; Naka, S; Ohmomo, Y; Yoshimoto, M | 1 |
Haramoto, M; Horibe, T; Kawakami, K; Kohno, M; Matsuzaki, K; Nakajima, O; Ohara, K; Yano, Y | 1 |
Cheng, CM; Hsu, CT; Lee, YJ; Ou, KL; Tsai, JS; Wang, WT; Wu, CM; Yang, TS | 1 |
Partridge, NC; Qin, L; Shimizu, E; Zhang, X; Zhu, J | 1 |
Loo, BW; Ma, L; Meng, X; Murphy, JD; Sun, X; Yu, J | 1 |
Pick, A; Wiese, M | 1 |
Akama-Garren, EH; Edalati, A; Lindstrom, TM; Petralia, JD; Robinson, WH; Ruiz, PJ; Stein, EA; Swanson, CD | 1 |
Fu, Z; Ge, H; Liu, H; Sun, Z | 1 |
Gong, K; Li, X; Liu, W; Luo, K; Wang, K | 1 |
Matsuo, K; Takada, Y | 1 |
Eda, T; Iwakura, Y; Mizuno, M; Nagata, K; Namba, H; Nawa, H; Okubo, T; Shibuya, M; Sotoyama, H; Wang, R | 1 |
Nguyen, DM; Xin, HW; Yang, JH | 1 |
Arndt-Jovin, DJ; Bunt, G; Fritsch, C; Jovin, TM; Klement, R; Klymchenko, AS; Loman, A; Ziomkiewicz, I | 1 |
Arnberg, F; Holmin, S; Lu, L; Olofsson, MH; Samén, E; Stone-Elander, S; Tegnebratt, T; Thorell, JO | 1 |
Chang, CM; Chang, WC; Chuang, HY; Hou, MF; Lee, YC; Lin, YC; Tsai, YT; Wang, JY; Wei, PL; Wong, JH | 1 |
Cai, L; Gao, S; Pu, P; Sun, J; Yang, W; Zhang, A; Zhang, K | 1 |
Leon Carrion, S; Sutter, CH; Sutter, TR | 1 |
Angelini, M; Benaiteau, F; Fleury, F; Gyulkhandanyan, A; Gyulkhandanyan, L; Le Béchec, M; Lecocq, MF; Logé, C; Reiter, E; Roussakis, C; Rousseau, B; Sakanyan, V | 1 |
Baltus, CB; Chuckowree, IS; Librizzi, M; Longo, A; Luparello, C; Spencer, J | 1 |
Liu, W; Qin, ZP; Xing, RC; Yao, RC; Zheng, J; Zheng, WH | 1 |
Dai, D; Li, XF; Liu, JJ; Wang, J; Wang, Q; Xu, WG; Zhang, Y; Zhu, YJ | 1 |
Campion, CM; Cole, JA; Leon Carrion, S; Mamidanna, G; Sutter, CH; Sutter, TR | 1 |
Hartel, I; Rieger, J; Ronellenfitsch, M; Steinbach, JP; Wanka, C; Wolking, S | 1 |
Alqahtani, S; Ashby, CR; Bates, SE; Chen, ZS; Deng, T; Gupta, P; Kaddoumi, A; Lei, YX; Wang, YJ; Wurpel, JND; Zhang, GN; Zhang, YK | 1 |
Abisoye-Ogunniyan, A; Davis, M; Ghebremedhin, A; Grizzle, W; Jones-Trich, J; Karanam, B; Lin, H; Salam, AB; Theodore, S; Wang, H; Yates, C | 1 |
Harter, PN; Mittelbronn, M; Pietsch, T; Reuter, D; Ronellenfitsch, MW; Senft, C; Steinbach, JP; Urban, H; Westphal, M; Zeiner, PS | 1 |
Lovicu, FJ; Shu, DY; Wojciechowski, M | 1 |
Cao, M; Chen, S; Du, J; Song, W; Wu, X; Xia, R | 1 |
Choung, S; Joung, KH; Kim, HJ; Kim, JM; Ku, BJ; Lee, ES | 1 |
Aoi, T; Fujisawa, M; Hinata, N; Koyanagi-Aoi, M; Suzuki, K; Uehara, K | 1 |
Furue, K; Furue, M; Ito, T; Nakahara, T; Tsuji, G | 1 |
Bergum, N; Garrett, SH; Knutson, P; Mehus, AA; Sens, DA; Sens, MA; Shrestha, S; Somji, S; Zhou, XD | 1 |
2 review(s) available for quinazolines and pd 153035
Article | Year |
---|---|
4-anilino-3-quinolinecarbonitriles: an emerging class of kinase inhibitors.
Topics: Aniline Compounds; Animals; Enzyme Inhibitors; ErbB Receptors; Inhibitory Concentration 50; Nitriles; Protein Binding; Protein Serine-Threonine Kinases; Quinazolines; src-Family Kinases; Tumor Cells, Cultured | 2002 |
PET screening of anticancer drugs. A faster route to drug/target evaluations in vivo.
Topics: Animals; Antineoplastic Agents; Drug Evaluation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Haplorhini; Humans; Image Processing, Computer-Assisted; Isotope Labeling; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Quinazolines; Radiopharmaceuticals; Rats; Tomography, Emission-Computed; Xenograft Model Antitumor Assays | 2003 |
2 trial(s) available for quinazolines and pd 153035
Article | Year |
---|---|
A pilot study on EGFR-targeted molecular imaging of PET/CT With 11C-PD153035 in human gliomas.
Topics: Adult; Aged; Biological Transport; Carbon Radioisotopes; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Middle Aged; Multimodal Imaging; Pilot Projects; Positron-Emission Tomography; Quinazolines; Tomography, X-Ray Computed | 2014 |
Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma.
Topics: Adaptor Proteins, Signal Transducing; Antibodies, Monoclonal, Humanized; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Calcium-Binding Proteins; Cohort Studies; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; ErbB Receptors; Female; Glioblastoma; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Microfilament Proteins; Necrosis; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Ribosomal Protein S6; Signal Transduction; Time Factors; Treatment Outcome; Tumor Suppressor Proteins | 2018 |
159 other study(ies) available for quinazolines and pd 153035
Article | Year |
---|---|
Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor.
Topics: ErbB Receptors; Humans; Isomerism; Magnetic Resonance Spectroscopy; Phosphorylation; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured | 1996 |
A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Gene Expression; Humans; Kinetics; Mice; Mitosis; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrosine | 1994 |
Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.
Topics: Aniline Compounds; Binding Sites; Blotting, Western; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Conformation; Molecular Structure; Phosphorylation; Protein Binding; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured | 1996 |
Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice.
Topics: Animals; Carcinoma, Squamous Cell; Cell Division; Enzyme Inhibitors; ErbB Receptors; Humans; Mice; Mice, Nude; Neoplasms; Quinazolines; Transplantation, Heterologous; Tumor Cells, Cultured | 1996 |
Tyrosine kinase inhibitor-sensitive contractile action of ethanol in gastric smooth muscle: comparison with the action of epidermal growth factor.
Topics: 1-Propanol; Animals; Calcium; Catechols; Cyclohexanones; Enzyme Inhibitors; Epidermal Growth Factor; Ethanol; Fomepizole; Genistein; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Indomethacin; Isoflavones; Male; Maleimides; Methanol; Muscle Contraction; Muscle, Smooth; Nitriles; Protein-Tyrosine Kinases; Pyrazoles; Quinazolines; Signal Transduction; Stomach; Tyrphostins | 1997 |
Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells.
Topics: Amphiregulin; Antineoplastic Agents; Breast Neoplasms; Cell Division; Collagenases; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gelatinases; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Neoplasm Metastasis; Quinazolines; Tumor Cells, Cultured; Up-Regulation | 1997 |
Requirement for epidermal growth factor receptor tyrosine kinase and for 12-lipoxygenase activity in the expression of 12-lipoxygenase in human epidermoid carcinoma cells.
Topics: Arachidonate 12-Lipoxygenase; Biotin; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Down-Regulation; ErbB Receptors; Humans; Lipoxygenase Inhibitors; Phalloidine; Phthalimides; Quinazolines; RNA, Messenger; Tumor Cells, Cultured | 1997 |
Cytoskeletal and morphological changes associated with the specific suppression of the epidermal growth factor receptor tyrosine kinase activity in A431 human epidermoid carcinoma.
Topics: Actins; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Division; Cytoskeleton; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured | 1997 |
A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Enzyme Inhibitors; ErbB Receptors; Intestinal Mucosa; Ligands; Oncogene Protein pp60(v-src); Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Rats; RNA, Messenger; Transforming Growth Factor alpha; Up-Regulation | 1997 |
Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture.
Topics: Adult; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Organ Culture Techniques; Quinazolines; Skin; Wound Healing | 1997 |
EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation.
Topics: Antibodies, Monoclonal; Cell Differentiation; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Keratinocytes; Phosphorylation; Quinazolines | 1997 |
Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol
Topics: Animals; Arachidonic Acid; Calcium; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Lipoprotein Lipase; Male; Mitogen-Activated Protein Kinase Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Receptors, Thrombin; Signal Transduction | 1998 |
Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells.
Topics: Apoptosis; Colonic Neoplasms; Endopeptidases; Enzyme Inhibitors; ErbB Receptors; Humans; Ligands; Protease Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathway.
Topics: Angiotensin II; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; GTP-Binding Proteins; Humans; Liver; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation | 1998 |
EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL.
Topics: Antibodies, Monoclonal; Apoptosis; bcl-X Protein; Enzyme Inhibitors; ErbB Receptors; Humans; Keratinocytes; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction | 1998 |
Inhibitors of the epidermal growth factor receptor protein tyrosine kinase: a quantitative structure-activity relationship analysis.
Topics: Drug Design; Enzyme Inhibitors; ErbB Receptors; Models, Statistical; Molecular Structure; Quinazolines; Regression Analysis; Structure-Activity Relationship | 1998 |
EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5.
Topics: Antibodies, Monoclonal; Apoptosis; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Enzyme Inhibitors; ErbB Receptors; Head and Neck Neoplasms; Humans; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrosine | 1998 |
PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Enzyme Inhibitors; ErbB Receptors; Female; Genes, erbB-2; Humans; Male; Phosphorylation; Prostatic Neoplasms; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Transfection; Uterine Cervical Neoplasms; Vulvar Neoplasms | 1997 |
Keratinocyte collagenase-1 expression requires an epidermal growth factor receptor autocrine mechanism.
Topics: Animals; Burns; Cell Movement; Cells, Cultured; Collagenases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Humans; In Situ Hybridization; Keratinocytes; Male; Matrix Metalloproteinase 1; Quinazolines; Swine; Transfection; Wound Healing | 1999 |
Involvement of tyrosine kinases on cyclooxygenase expression and prostaglandin E2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor.
Topics: Benzoquinones; Cells, Cultured; Child; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Interleukin-1; Isoenzymes; Lactams, Macrocyclic; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Quinazolines; Quinones; Rifabutin; RNA, Messenger; Sulfonamides; Time Factors | 1999 |
Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy.
Topics: Animals; CHO Cells; Cricetinae; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Microscopy, Atomic Force; Microscopy, Confocal; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Tumor Cells, Cultured | 1999 |
In vivo evaluation of the biodistribution of 11C-labeled PD153035 in rats without and with neuroblastoma implants.
Topics: Animals; Carbon Radioisotopes; ErbB Receptors; Evaluation Studies as Topic; Female; Humans; Neoplasm Transplantation; Neuroblastoma; Quinazolines; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tomography, Emission-Computed; Tumor Cells, Cultured | 1999 |
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
Topics: Adenocarcinoma; Animals; Autocrine Communication; Breast Neoplasms; Cell Line; Diffusion Chambers, Culture; Epidermal Growth Factor; ErbB Receptors; Estrenes; Female; Humans; Immunoblotting; Isoenzymes; Male; Mice; Neoplasm Invasiveness; Phosphodiesterase Inhibitors; Phospholipase C gamma; Phosphorylation; Prostatic Neoplasms; Pyrrolidinones; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Type C Phospholipases | 1999 |
Apoptosis and growth inhibition of head and neck tumor cell line induced by epidermal growth factor receptor tyrosine kinase inhibitor.
Topics: Apoptosis; Carcinoma, Squamous Cell; Enzyme Inhibitors; ErbB Receptors; Gingival Neoplasms; Humans; Quinazolines; Tumor Cells, Cultured | 1999 |
The first peak of the UVB irradiation-dependent biphasic induction of vascular endothelial growth factor (VEGF) is due to phosphorylation of the epidermal growth factor receptor and independent of autocrine transforming growth factor alpha.
Topics: Antibodies; Autocrine Communication; Cell Line; Endothelial Growth Factors; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epidermal Cells; Epidermis; ErbB Receptors; Humans; Lymphokines; Models, Biological; Phosphorylation; Protein Isoforms; Quinazolines; RNA, Messenger; Time Factors; Transforming Growth Factor alpha; Ultraviolet Rays; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival.
Topics: Cell Survival; Cells, Cultured; ErbB Receptors; Humans; Keratinocytes; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Signal Transduction; Ultraviolet Rays | 2000 |
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest.
Topics: Activin Receptors, Type I; Androstadienes; Animals; Cells, Cultured; Chromones; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Fibroblasts; G1 Phase; Morpholines; Mutation; Phosphoprotein Phosphatases; Phosphorylation; Protein Biosynthesis; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Quinazolines; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Ribosomal Protein S6 Kinases; S Phase; Signal Transduction; Sirolimus; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Wortmannin | 2000 |
A role for endogenous TGFalpha and associated signaling pathways in the differentiation of lens fiber cells.
Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Chickens; Cyclic AMP; Enzyme Inhibitors; ErbB Receptors; Eye Proteins; Intermediate Filament Proteins; Isoproterenol; Lens, Crystalline; Mitogen-Activated Protein Kinase 1; Phosphorylation; Quinazolines; Receptor Cross-Talk; Signal Transduction; Transforming Growth Factor alpha | 2001 |
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
Topics: Adenocarcinoma, Clear Cell; Cell Division; Cell Hypoxia; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Genes, Tumor Suppressor; Growth Substances; Humans; Insulin; Kidney Neoplasms; Ligases; Oligodeoxyribonucleotides, Antisense; Proteins; Quinazolines; Selenium; Transferrin; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins; Ubiquitin-Protein Ligases; von Hippel-Lindau Disease; Von Hippel-Lindau Tumor Suppressor Protein | 2001 |
BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoblotting; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuregulin-1; Organic Chemicals; Phosphorylation; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Recombinant Proteins; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins | 2001 |
Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.
Topics: Blotting, Western; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Interleukin-1; Keratinocytes; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Models, Biological; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinazolines; Time Factors; Tyrphostins | 2001 |
EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes.
Topics: Adult; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Glutathione Transferase; Humans; Interleukin-1; Interleukin-1 Receptor-Associated Kinases; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Kinases; Quinazolines; Signal Transduction; Skin; Time Factors; Transcription Factor AP-1; Ultraviolet Rays | 2001 |
Epidermal growth factor induction of apolipoprotein A-I is mediated by the Ras-MAP kinase cascade and Sp1.
Topics: Amino Acid Sequence; Apolipoprotein A-I; Binding Sites; Blotting, Western; Chloramphenicol O-Acetyltransferase; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genes, Dominant; Genes, ras; Genes, Reporter; Humans; Insulin; MAP Kinase Signaling System; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Protein Synthesis Inhibitors; Quinazolines; ras Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sp1 Transcription Factor; Threonine; Time Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Up-Regulation | 2001 |
DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.
Topics: Antineoplastic Agents; Base Sequence; Binding Sites; Circular Dichroism; Densitometry; DNA; DNA Footprinting; DNA, Superhelical; Electrophoresis, Agar Gel; Enzyme Inhibitors; ErbB Receptors; Humans; Intercalating Agents; Molecular Sequence Data; Protein Denaturation; Quinazolines; Spectrometry, Fluorescence | 2001 |
Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Kinetics; Ligands; Lung Neoplasms; Mammary Neoplasms, Experimental; Phthalimides; Quinazolines; Rats; Signal Transduction; Tumor Cells, Cultured | 2001 |
Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells.
Topics: Antigens, CD; Autocrine Communication; Carcinoma; Cell Adhesion; Cell Movement; Cell Size; DNA, Antisense; DNA, Complementary; Enzyme Induction; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin alpha3; Integrin alpha6; Integrins; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Proteins; Ovarian Neoplasms; Phenotype; Quinazolines; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transfection; Tumor Cells, Cultured | 2001 |
Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Ligands; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Phenylalanine; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Quinazolines; Signal Transduction; Tetradecanoylphorbol Acetate; Thiophenes; Transcription Factor AP-1; Transcriptional Activation; Tyrphostins | 2001 |
Lymnaea epidermal growth factor promotes axonal regeneration in CNS organ culture.
Topics: Animals; Axons; Carbazoles; Central Nervous System; Disease Models, Animal; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Indole Alkaloids; Lymnaea; Nerve Crush; Nerve Regeneration; Neurons; Organ Culture Techniques; Quinazolines; Reproducibility of Results | 2001 |
1,4-dioxane-fused 4-anilinoquinazoline as inhibitors of epidermal growth factor receptor kinase.
Topics: Antineoplastic Agents; Cell Division; Dioxanes; ErbB Receptors; Humans; Protein-Tyrosine Kinases; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines.
Topics: Breast Neoplasms; Cell Division; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Female; Humans; Oncogene Proteins v-erbB; Phosphorylation; Quinazolines; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2002 |
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
Topics: Animals; Cell Line; Colonic Neoplasms; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Gastric Mucosa; Genes, src; Humans; Hypertrophy; MAP Kinase Signaling System; Matrix Metalloproteinases; Mitogen-Activated Protein Kinase 1; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Transcriptional Activation; Tyrphostins | 2002 |
Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation.
Topics: Animals; Blotting, Western; Cell Line; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Quinazolines; Ribosomal Protein S6 Kinases; Signal Transduction; Transfection; Tyrosine; Tyrphostins; Ultraviolet Rays | 2001 |
Role of Ras in metal-induced EGF receptor signaling and NF-kappaB activation in human airway epithelial cells.
Topics: Arsenic; Bronchi; Cell Line, Transformed; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; I-kappa B Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Metals; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Quinazolines; Respiratory Mucosa; Vanadium; Zinc | 2002 |
Regulation of cultured rat hepatocyte proliferation by stellate cells.
Topics: Albumins; Animals; Anti-Ulcer Agents; Anticoagulants; Antineoplastic Agents; Carbenoxolone; Cell Communication; Cell Count; Cell Division; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; DNA; ErbB Receptors; Gap Junctions; Heparan Sulfate Proteoglycans; Heparin; Heparitin Sulfate; Hepatocyte Growth Factor; Hepatocytes; Male; Proto-Oncogene Proteins c-met; Quinazolines; Rats; Rats, Wistar; Specific Pathogen-Free Organisms | 2002 |
Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Blotting, Western; Cell Division; Chromones; Colorectal Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Farnesyltranstransferase; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Quinolones; Transfection; Tumor Cells, Cultured | 2002 |
Okadaic acid-induced EGF receptor and MAP kinase activation does not require reactive oxygen species in primary keratinocytes.
Topics: Carcinogens; Cells, Cultured; Enzyme Activation; ErbB Receptors; Humans; Keratinocytes; Lipid Peroxidation; Mitogen-Activated Protein Kinases; Okadaic Acid; Quinazolines; Reactive Oxygen Species | 2002 |
EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness.
Topics: Carcinoma, Signet Ring Cell; Cell Movement; Collagen; Drug Combinations; Enzyme Inhibitors; ErbB Receptors; Estrenes; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Herpesvirus 4, Human; Humans; Integrins; Isoenzymes; Laminin; Neoplasm Invasiveness; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Pyrrolidinones; Quinazolines; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured; Type C Phospholipases | 2002 |
Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line; ErbB Receptors; Genistein; Membrane Glycoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Recombinant Proteins; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2002 |
Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium.
Topics: Animals; CDX2 Transcription Factor; Cell Division; Cell Line; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Homeodomain Proteins; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Male; Mice; Promoter Regions, Genetic; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Transcription, Genetic; Transfection | 2002 |
Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.
Topics: Androstadienes; Butadienes; Cell Line; Chlorides; Epithelial Cells; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Nitriles; Nitrobenzenes; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Pyridines; Pyrimidines; Quinazolines; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Sulfonamides; Thrombin; Tyrphostins; Wortmannin | 2002 |
Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy.
Topics: Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Division; Cells, Cultured; Collagen; Down-Regulation; Endostatins; Endothelium, Vascular; ErbB Receptors; Humans; Immunohistochemistry; Liposomes; Mice; Mice, Inbred C3H; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Oligonucleotides, Antisense; Peptide Fragments; Plasmids; Quinazolines; Recombinant Proteins; Time Factors; Transfection; Tumor Cells, Cultured; Umbilical Veins | 2002 |
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
Topics: Animals; Aorta; Blood Pressure; Collagen Type I; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibrosis; Flavonoids; In Vitro Techniques; Luciferases; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Quinazolines; Tyrphostins; Vasoconstriction | 2003 |
Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Line; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Humans; Imatinib Mesylate; MAP Kinase Signaling System; Piperazines; Point Mutation; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Threonine; Transfection | 2003 |
Quantitative image analysis of cellular protein translocation induced by magnetic microspheres: application to the EGF receptor.
Topics: Animals; Cell Line, Tumor; CHO Cells; Cricetinae; Enzyme Inhibitors; ErbB Receptors; Fluorescent Dyes; Green Fluorescent Proteins; Humans; Image Processing, Computer-Assisted; Luminescent Proteins; Magnetics; Microscopy, Confocal; Microscopy, Fluorescence; Microspheres; Models, Biological; Protein Transport; Quinazolines; Signal Transduction; Time Factors | 2003 |
Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.
Topics: Aging; Animals; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Gastric Mucosa; Male; Mitogen-Activated Protein Kinase Kinases; Pyrimidines; Quinazolines; Rats; Rats, Inbred F344; Signal Transduction; src-Family Kinases; Transcription Factor AP-1; Transforming Growth Factor alpha | 2003 |
Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Cell Division; Cell Separation; Ceramides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Male; Membrane Potentials; Mitochondria; Necrosis; Prostatic Neoplasms; Protease Inhibitors; Quinazolines; Tumor Cells, Cultured | 2003 |
Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells.
Topics: Animals; Apoptosis; bcl-X Protein; Butadienes; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Quinazolines; Up-Regulation | 2003 |
Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.
Topics: Blotting, Western; Cell Line; Detergents; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Genes, src; Humans; Phosphorylation; Quinazolines; Signal Transduction; Transcriptional Activation; Zinc | 2003 |
Expression of ErbB receptors in ES cell-derived cardiomyocytes.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Division; Culture Media, Serum-Free; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Green Fluorescent Proteins; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Luminescent Proteins; Mice; Mice, Transgenic; Microscopy, Fluorescence; Myocardium; Neuregulin-1; Quinazolines; Receptor, ErbB-4; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stem Cells; Time Factors; Transcription Factors; Tyrphostins; Xenopus Proteins | 2003 |
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.
Topics: Antibodies; Bronchi; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Matrix Metalloproteinase Inhibitors; Phosphorylation; Quinazolines; Tyrosine; Zinc | 2004 |
RELEASE OF PHOSPHORUS-32-CONTAINING COMPOUNDS FROM MICROCOCCUS LYSODEIKTICUS TREATED WITH CHLORHEXIDINE.
Topics: Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Micrococcus; Pharmacology; Phosphorus; Phosphorus Isotopes; Quinazolines; Research | 1964 |
Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas.
Topics: Antineoplastic Agents; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p27; DNA-Binding Proteins; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Glioma; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; STAT3 Transcription Factor; Trans-Activators; Tumor Suppressor Proteins | 2003 |
EphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration.
Topics: Animals; Cell Movement; Cells, Cultured; CHO Cells; Cricetinae; Endothelium, Vascular; Enzyme Inhibitors; Ephrin-B2; ErbB Receptors; Humans; Microcirculation; Phosphorylation; Pyrimidines; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, EphB4; Recombinant Proteins; Signal Transduction; src-Family Kinases; Vascular Endothelial Growth Factors | 2004 |
Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Quinazolines | 2004 |
Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition.
Topics: Animals; Capillaries; Collagen; Collagen Type I; Creatinine; Endothelin-1; ErbB Receptors; Fibrosis; Gefitinib; Gene Expression Regulation; Genes, Reporter; Glomerulosclerosis, Focal Segmental; Hypertension; Ischemia; Kidney; Kidney Cortex; Kidney Diseases; Kidney Glomerulus; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proteinuria; Quinazolines; Rats; Rats, Sprague-Dawley | 2004 |
Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme.
Topics: Active Transport, Cell Nucleus; Adipocytes; Anilides; Animals; Blotting, Western; Cattle; Cell Differentiation; Cell Line; Cell Proliferation; Chromans; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Gene Expression Regulation; Humans; Immunoprecipitation; Ligands; Membrane Glycoproteins; Membrane Proteins; Microscopy, Fluorescence; Phosphorylation; PPAR gamma; Promoter Regions, Genetic; Quinazolines; Ribonucleases; RNA, Messenger; Signal Transduction; Thiazolidinediones; Time Factors; Troglitazone; Uroplakin Ia; Uroplakin Ib; Uroplakin II; Uroplakin III; Urothelium | 2004 |
Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes.
Topics: Adult; Amphiregulin; Antibodies, Monoclonal; Bacterial Proteins; Cell Division; Cells, Cultured; Dactinomycin; EGF Family of Proteins; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression Regulation; Genes, erbB-1; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Infant, Newborn; Intercellular Signaling Peptides and Proteins; Keratinocytes; Parathyroid Hormone-Related Protein; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha | 2004 |
Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Androstadienes; Animals; Bucladesine; Choline; Colforsin; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Isoproterenol; Phosphoinositide-3 Kinase Inhibitors; Phospholipids; Pyrimidines; Quinazolines; Rats; Receptors, Adrenergic, beta; Saliva; src-Family Kinases; Sublingual Gland; Transcriptional Activation; Wortmannin | 2004 |
Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells.
Topics: Cell Differentiation; Chromans; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoblotting; Immunohistochemistry; Keratins; Metaplasia; Microscopy, Fluorescence; Quinazolines; Receptors, Cytoplasmic and Nuclear; Ribonucleases; RNA, Messenger; Signal Transduction; Thiazolidinediones; Transcription Factors; Troglitazone; Urothelium | 2004 |
Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis.
Topics: Apoptosis; Brain Neoplasms; Caspase 8; Caspases; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Fas Ligand Protein; Glioma; Humans; Membrane Glycoproteins; Quinazolines; Receptor, IGF Type 1; Ribosomal Protein S6; Signal Transduction; Tumor Suppressor Protein p53; Tyrphostins | 2004 |
[Role of PD153035 in the induction of apoptosis of XG-1 myeloma cell line].
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; DNA-Binding Proteins; ErbB Receptors; Humans; Multiple Myeloma; Quinazolines; STAT3 Transcription Factor; Trans-Activators | 2004 |
Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis.
Topics: Arachidonate 15-Lipoxygenase; Blotting, Western; Cell Membrane; Cell Proliferation; Cells, Cultured; Chromatography, High Pressure Liquid; Cornea; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Green Fluorescent Proteins; Hepatocyte Growth Factor; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Lipoxygenase; MAP Kinase Kinase Kinases; Microscopy, Fluorescence; Models, Biological; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Transport; Quinazolines; Signal Transduction; Time Factors; Transfection; Wound Healing | 2005 |
Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases.
Topics: Animals; Cadmium; Chloride Channels; Enzyme Inhibitors; ErbB Receptors; Genistein; Heart Ventricles; Membrane Potentials; Pyrimidines; Quinazolines; Rabbits; src-Family Kinases; Tamoxifen; Ventricular Function | 2005 |
High performance liquid chromatography analysis of a 4-anilinoquinazoline derivative (PD153035), a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in rat plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Enzyme Inhibitors; ErbB Receptors; Male; Quinazolines; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2005 |
Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery.
Topics: Alkaloids; Animals; Benzophenanthridines; Binding Sites; Binding, Competitive; Catalytic Domain; Chromatography, Affinity; Drug Evaluation, Preclinical; Humans; Imidazoles; Mass Spectrometry; Mice; Molecular Structure; Peptides; Phosphorylation; Protein Binding; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Quinazolines; Receptor, EphB2; Recombinant Proteins | 2005 |
An EGF receptor inhibitor induces RAR-beta expression in breast and ovarian cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; ErbB Receptors; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Ovarian Neoplasms; Promoter Regions, Genetic; Quinazolines; Receptor, ErbB-2; Receptors, Retinoic Acid; RNA, Messenger | 2005 |
Porphyromonas gingivalis lipopolysaccharide-induced up-regulation in endothelin-1 interferes with salivary mucin synthesis via epidermal growth factor receptor transactivation.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; ErbB Receptors; Lipopolysaccharides; Mucins; Oligopeptides; Porphyromonas gingivalis; Pyrimidines; Quinazolines; Rats; Saliva; Salivary Glands; src-Family Kinases; Time Factors; Transcriptional Activation; Trypan Blue; Up-Regulation | 2004 |
Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Collagen; DNA; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Immunoprecipitation; Inflammation; NF-kappa B; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Oligonucleotide Probes; Phosphorylation; Polymerase Chain Reaction; Quinazolines; RNA; Tyrosine; Up-Regulation; Uterine Cervical Neoplasms | 2005 |
The selective epidermal growth factor receptor tyrosine kinase inhibitor PD153035 suppresses expression of prometastasis phenotypes in malignant pleural mesothelioma cells in vitro.
Topics: Antineoplastic Agents; Cell Movement; Cell Proliferation; Cocarcinogenesis; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Neoplastic; Humans; Laminin; Mesothelioma; Neoplasm Invasiveness; Neoplasm Metastasis; Phenotype; Pleural Neoplasms; Proteoglycans; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tumor Stem Cell Assay; Vascular Endothelial Growth Factor A | 2005 |
Autocrine regulation of human urothelial cell proliferation and migration during regenerative responses in vitro.
Topics: Amphiregulin; Antibodies; Autocrine Communication; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Gene Expression; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Quinazolines; Regeneration; Transforming Growth Factor alpha; Urothelium; Wound Healing | 2005 |
Comparison of ELISA-based tyrosine kinase assays for screening EGFR inhibitors.
Topics: Animals; Baculoviridae; Cell Line; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Humans; In Vitro Techniques; Kinetics; Peptides; Quinazolines; Recombinant Proteins; Reproducibility of Results; Spodoptera; Substrate Specificity; Transfection | 2005 |
Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.
Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Resistance, Neoplasm; Drug Synergism; Embryo, Mammalian; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Inhibitor of Apoptosis Proteins; Keratinocytes; Melanoma; Mice; Mice, Knockout; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Proteins; Pentacyclic Triterpenes; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Survivin; Time Factors; Triterpenes | 2005 |
Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin.
Topics: Anti-Bacterial Agents; Cells, Cultured; Chemokine CCL17; Chemokines, CC; ErbB Receptors; Humans; Interferon-gamma; Keratinocytes; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Quinazolines; Roxithromycin; Sesquiterpenes; Signal Transduction; Sulfones; Tumor Necrosis Factor-alpha | 2005 |
Up-regulation in endothelin-1 by Helicobacter pylori lipopolysaccharide interferes with gastric mucin synthesis via epidermal growth factor receptor transactivation.
Topics: Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Inhibitors; ErbB Receptors; Gastric Mucins; Gastric Mucosa; Helicobacter pylori; In Vitro Techniques; Lipopolysaccharides; Metalloendopeptidases; Quinazolines; Rats; Rats, Sprague-Dawley; Transcriptional Activation; Up-Regulation | 2005 |
Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Electrophysiology; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; gamma-Aminobutyric Acid; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ligands; Neurons; Protein Subunits; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Transforming Growth Factor alpha | 2006 |
The epidermal growth factor receptor (EGFR)-S442F mutant displays increased affinity for neuregulin-2beta and agonist-independent coupling with downstream signalling events.
Topics: Amino Acid Substitution; Animals; Apoptosis; Binding Sites; Cell Line; Chromones; Epidermal Growth Factor; ErbB Receptors; Genes, erbB-1; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Mice; Morpholines; Mutation, Missense; Myeloid Cells; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphorylation; Point Mutation; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quinazolines; Recombinant Fusion Proteins; Signal Transduction; Transfection | 2006 |
Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment.
Topics: Adenosine Triphosphate; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 7; Caspase Inhibitors; Caspases; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; ErbB Receptors; Estrogen Antagonists; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Indoles; Quinazolines; Time Factors | 2006 |
COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Down-Regulation; Enzyme Activation; Female; Glycoproteins; Humans; Imidazoles; Lymphangiogenesis; Molecular Sequence Data; Pyrazoles; Pyridines; Pyrimidines; Quinazolines; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; RNA, Small Interfering; Structure-Activity Relationship; Vascular Endothelial Growth Factor C; Vesicular Transport Proteins | 2006 |
PPARgamma-regulated tight junction development during human urothelial cytodifferentiation.
Topics: Anilides; Benzamides; Calcium; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Claudin-1; Claudin-3; Claudin-4; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Membrane Proteins; Phosphoproteins; PPAR gamma; Proteasome Endopeptidase Complex; Pyridines; Quinazolines; Thiazolidinediones; Tight Junctions; Ureter; Urothelium; Zonula Occludens-1 Protein | 2006 |
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts.
Topics: Arachidonic Acid; Blotting, Western; Cells, Cultured; Child; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Imidazoles; Indoles; Interleukin-1beta; Intramolecular Oxidoreductases; Maleimides; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Prostaglandin D2; Prostaglandin-E Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2006 |
Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells.
Topics: Acetylation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Morpholines; Neoplasm Proteins; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Survivin; Time Factors | 2006 |
Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.
Topics: Aged; Amphiregulin; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Line, Tumor; Cell Transformation, Neoplastic; EGF Family of Proteins; ErbB Receptors; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Quinazolines; RNA, Small Interfering; Signal Transduction; Up-Regulation | 2006 |
Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines | 2007 |
UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway.
Topics: Androstadienes; Blotting, Western; Cell Line; Chromones; Dose-Response Relationship, Radiation; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Keratinocytes; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Tumor Suppressor Proteins; Ultraviolet Rays; Vascular Endothelial Growth Factor A; Wortmannin | 2006 |
EGF receptor clustering is induced by a 0.4 mT power frequency magnetic field and blocked by the EGF receptor tyrosine kinase inhibitor PD153035.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Electromagnetic Fields; ErbB Receptors; Flow Cytometry; Microscopy, Atomic Force; Microscopy, Confocal; Microscopy, Electron, Transmission; Quinazolines | 2007 |
Control of tight junctional sealing: role of epidermal growth factor.
Topics: Adolescent; Adult; Animals; Cell Membrane Permeability; Cells, Cultured; Claudin-1; Claudin-4; Dogs; Electric Impedance; Epidermal Growth Factor; ErbB Receptors; Humans; Male; Membrane Proteins; Quinazolines; Tight Junctions | 2007 |
The tyrosine kinase inhibitor PD153035: implication of labeling position on radiometabolites formed in vitro.
Topics: Animals; Carbon Radioisotopes; ErbB Receptors; Humans; Isotope Labeling; Male; Protein Kinase Inhibitors; Quinazolines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Species Specificity | 2006 |
Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Carcinoma, Renal Cell; Cell Cycle; Cell Death; Cell Survival; Drug Administration Schedule; Drug Synergism; ErbB Receptors; Inhibitory Concentration 50; Kidney Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; Quinazolines | 2007 |
Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; CpG Islands; DNA Methylation; Enzyme Inhibitors; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Quinazolines; Receptors, Retinoic Acid; RNA Processing, Post-Transcriptional; Transcription, Genetic; Tyrphostins; Up-Regulation | 2007 |
Protein C is an autocrine growth factor for human skin keratinocytes.
Topics: Antibodies, Monoclonal; Antigens, CD; Autocrine Communication; Blood Coagulation; Cell Proliferation; Cells, Cultured; Endothelial Protein C Receptor; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Humans; Inflammation; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein C; Quinazolines; Receptors, Cell Surface; RNA, Small Interfering; Skin; Wound Healing | 2007 |
Epidermal growth factor-, transforming growth factor-beta-, retinoic acid- and 1,25-dihydroxyvitamin D3-regulated expression of the novel protein PTPIP51 in keratinocytes.
Topics: Calcitriol; Cell Line; Cell Nucleus; Cytoplasm; Epidermal Growth Factor; Gene Expression Regulation; Humans; Keratinocytes; Mitochondrial Proteins; Protein Tyrosine Phosphatases; Quinazolines; RNA, Messenger; Transforming Growth Factor beta; Tretinoin | 2006 |
Immortalization of human urothelial cells by human papillomavirus type 16 E6 and E7 genes in a defined serum-free system.
Topics: Animals; Cell Cycle; Cell Growth Processes; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Clone Cells; Culture Media, Serum-Free; Epidermal Growth Factor; ErbB Receptors; Genes, Viral; Human papillomavirus 16; Humans; Karyotyping; Keratins; Mice; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Papillomavirus Infections; Phenotype; Quinazolines; Repressor Proteins; Telomerase; Urothelium | 2007 |
[Expressions of epidermal growth factor receptor signaling substances in gastric mucosal cells influenced by serum derived from rats treated with electroacupuncture at stomach meridian acupoints].
Topics: Acupuncture Points; Animals; Electroacupuncture; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Female; Gastric Mucosa; Gene Expression; Male; Phospholipase C gamma; Protein Kinase C; Proto-Oncogene Proteins c-myc; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Restraint, Physical; Reverse Transcriptase Polymerase Chain Reaction; Serum; Signal Transduction; Stomach Diseases | 2007 |
The DNA-binding epidermal growth factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-beta tumor-suppressor gene in breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; DNA; ErbB Receptors; Genes, Tumor Suppressor; Humans; Intercalating Agents; Protein Kinase Inhibitors; Quinazolines; Receptors, Retinoic Acid; Up-Regulation | 2007 |
Further characterization of the epidermal growth factor receptor ligand 11C-PD153035.
Topics: Animals; Carbon Radioisotopes; Cell Line, Tumor; ErbB Receptors; Female; Humans; Ligands; Mice; Mice, Inbred BALB C; Mice, Nude; Positron-Emission Tomography; Quinazolines | 2007 |
Assessment of 11C-labeled-4-N-(3-bromoanilino)-6,7-dimethoxyquinazoline as a positron emission tomography agent to monitor epidermal growth factor receptor expression.
Topics: Animals; Biomarkers, Tumor; Carbon Radioisotopes; Cell Line, Tumor; ErbB Receptors; Female; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Organ Specificity; Positron-Emission Tomography; Quinazolines | 2007 |
Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages.
Topics: Animals; Benzoflavones; Cell Differentiation; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Genistein; Hazardous Substances; Humans; Macrophages; MAP Kinase Signaling System; Mice; Phosphorylation; Polychlorinated Dibenzodioxins; Pyrimidines; Quinazolines; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; src-Family Kinases; Tumor Necrosis Factor-alpha | 2007 |
Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; Mice; Ovarian Neoplasms; Paclitaxel; Protein Kinase Inhibitors; Quinazolines; Signal Transduction | 2008 |
Antitumor activity of a novel EGFR tyrosine kinase inhibitor against human lung carcinoma in vitro and in vivo.
Topics: Adenocarcinoma; Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinazolines; Xenograft Model Antitumor Assays | 2009 |
Biochemical assay-based selectivity profiling of clinically relevant kinase inhibitors on mutant forms of EGF receptor.
Topics: Aminoquinolines; Aniline Compounds; Biological Assay; Drug Resistance; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Inhibitory Concentration 50; Morpholines; Mutant Proteins; Protein Kinase Inhibitors; Quinazolines; Substrate Specificity; Tyrphostins | 2008 |
HTS assays using a disease-relevant cell model for interrogating the MAP kinase pathway initiated by multiple receptors.
Topics: Cell Line, Tumor; Epidermal Growth Factor; Female; Hepatocyte Growth Factor; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Proto-Oncogene Proteins; Quinazolines; Receptors, Cell Surface | 2008 |
[Molecular imaging of epidermal growth factor receptor in glioma-bearing rats].
Topics: Animals; Brain Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; ErbB Receptors; Gastrointestinal Tract; Glioma; Liver; Male; Neoplasm Transplantation; Positron-Emission Tomography; Quinazolines; Rats; Rats, Wistar; Tissue Distribution; Tomography, X-Ray Computed | 2008 |
Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor.
Topics: Adenocarcinoma; Amphiregulin; Autoantibodies; Cell Line, Tumor; Cell Proliferation; EGF Family of Proteins; ErbB Receptors; Esophageal Neoplasms; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Leptin; Matrix Metalloproteinases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Transforming Growth Factor alpha; Tyrphostins | 2008 |
Growth factors involved in aqueous humour-induced lens cell proliferation.
Topics: Animals; Aqueous Humor; Cell Proliferation; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; Fibroblast Growth Factors; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Lens, Crystalline; Platelet-Derived Growth Factor; Pyrroles; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tyrphostins | 2009 |
Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling.
Topics: Blotting, Western; Butyrates; Cell Line, Tumor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Genes, ras; Humans; Immunoprecipitation; Indoles; Organometallic Compounds; Phenols; Phosphorylation; Protein Kinase C-alpha; Quinazolines; raf Kinases; Receptors, Platelet-Derived Growth Factor; src-Family Kinases; Sulfonamides; Transfection | 2009 |
B5, a novel pyrrole-substituted indolinone, exerts potent antitumor efficacy through G2/M cell cycle arrest.
Topics: Antineoplastic Agents; Bromodeoxyuridine; CDC2 Protein Kinase; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin B1; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; G2 Phase; Humans; Imidazoles; Indoles; Mitosis; Pyrroles; Quinazolines | 2010 |
PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans.
Topics: Adult; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Female; Humans; Ligands; Lung Neoplasms; Male; Metabolic Clearance Rate; Positron-Emission Tomography; Quinazolines; Radiometry; Radiopharmaceuticals; Tissue Distribution; Tomography, X-Ray Computed; Young Adult | 2009 |
F84, a quinazoline derivative, exhibits high potent antitumor activity against human gynecologic malignancies.
Topics: Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; ErbB Receptors; Female; Genital Neoplasms, Female; Humans; Mice; Mitogen-Activated Protein Kinases; Organ Size; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Xenograft Model Antitumor Assays | 2010 |
The unfolded protein response is activated in differentiating epidermal keratinocytes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; ATP-Binding Cassette Transporters; Carcinoma, Squamous Cell; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; DNA-Binding Proteins; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Immunohistochemistry; Keratinocytes; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Middle Aged; Protein Disulfide-Isomerases; Protein Folding; Protein Transport; Psoriasis; Quinazolines; Regulatory Factor X Transcription Factors; RNA, Messenger; Signal Transduction; Transcription Factors; Ubiquitin-Protein Ligases; X-Box Binding Protein 1 | 2009 |
Molecular imaging of EGFR: it's time to go beyond receptor expression.
Topics: Adult; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Female; Humans; Ligands; Lung Neoplasms; Male; Metabolic Clearance Rate; Molecular Probe Techniques; Positron-Emission Tomography; Quinazolines; Radiometry; Radiopharmaceuticals; Tissue Distribution; Tomography, X-Ray Computed; Young Adult | 2009 |
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
Topics: Anthracenes; Butadienes; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Imidazoles; Lactones; MAP Kinase Kinase Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Resorcinols; RNA, Small Interfering; Serine; Signal Transduction; Threonine; Tumor Necrosis Factor-alpha | 2009 |
EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice.
Topics: Adiponectin; Adipose Tissue; Animals; Blood Glucose; Dietary Fats; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Enzymologic; Glucose Tolerance Test; Hypoglycemic Agents; Immunoblotting; Immunoprecipitation; Inflammation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Leptin; Liver; Macrophages; Male; Mice; Muscle, Skeletal; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Tumor Necrosis Factor-alpha | 2009 |
EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells.
Topics: Amino Acid Sequence; Cell Line, Tumor; ErbB Receptors; Extracellular Matrix Proteins; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Pancreatic Neoplasms; Phosphorylation; Phylogeny; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Sequence Alignment | 2009 |
Potent cardioprotective effect of the 4-anilinoquinazoline derivative PD153035: involvement of mitochondrial K(ATP) channel activation.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Calcium; Cardiotonic Agents; Cell Respiration; Cyanides; Heart Function Tests; In Vitro Techniques; Ion Channel Gating; Male; Mice; Mitochondria; Myocardial Reperfusion Injury; Myocardium; Permeability; Phosphorylation; Potassium; Potassium Channels; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Wistar | 2010 |
Synthesis and initial tumor affinity testing of iodine-123 labelled EGFR-affine agents as potential imaging probes for hormone-refractory prostate cancer.
Topics: Animals; Antibodies, Monoclonal; Biological Transport; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Gene Expression Regulation, Neoplastic; Hormones; Humans; Iodine Radioisotopes; Male; Mice; Molecular Imaging; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Radionuclide Imaging; Rats; Tomography; Xenograft Model Antitumor Assays | 2010 |
Epidermal growth factor receptor tyrosine kinase inhibitors induce CCL2 and CCL5 via reduction in IL-1R2 in keratinocytes.
Topics: Acneiform Eruptions; Adolescent; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Cell Line; Enzyme Inhibitors; ErbB Receptors; Female; Gefitinib; Humans; Interleukin-1; Keratinocytes; Lung Neoplasms; Male; Middle Aged; Quinazolines; Receptors, Interleukin-1; Receptors, Interleukin-1 Type II; RNA, Messenger; Signal Transduction | 2010 |
Gastrin-releasing peptide promotes the growth of HepG2 cells via EGFR-independent ERK1/2 activation.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Enzyme Activation; ErbB Receptors; Gastrin-Releasing Peptide; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Indoles; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Receptors, Bombesin | 2010 |
Signaling through erbB receptors is a critical functional regulator in the mature cochlea.
Topics: Animals; Cell Count; Cochlea; Evoked Potentials, Auditory, Brain Stem; Female; Gene Expression; Guinea Pigs; Hair Cells, Auditory, Outer; Microinjections; Neurotrophin 3; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptors, Glutamate; Spiral Ganglion; Time Factors | 2010 |
Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics.
Topics: Amyloid beta-Protein Precursor; Androstadienes; Antibodies, Monoclonal; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cystatin C; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; ErbB Receptors; Humans; Immunohistochemistry; Nasopharyngeal Neoplasms; Proteomics; Quinazolines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transforming Growth Factor alpha; Wortmannin | 2010 |
Evaluation of radioiodinated quinazoline derivative as a new ligand for EGF receptor tyrosine kinase activity using SPECT.
Topics: Animals; Cell Line, Tumor; ErbB Receptors; Humans; Iodine Radioisotopes; Ligands; Male; Mice; Neoplasms; Protein Kinase Inhibitors; Quinazolines; Substrate Specificity; Tomography, Emission-Computed, Single-Photon | 2011 |
A novel hybrid peptide targeting EGFR-expressing cancers.
Topics: Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Mice; Mutant Chimeric Proteins; Neoplasm Transplantation; Neoplasms; Quinazolines; Receptor Protein-Tyrosine Kinases; Transplantation, Heterologous | 2011 |
Determining the binding mode and binding affinity constant of tyrosine kinase inhibitor PD153035 to DNA using optical tweezers.
Topics: Antineoplastic Agents; DNA; Humans; Intercalating Agents; Optical Tweezers; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Thermodynamics | 2011 |
EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix.
Topics: 3T3 Cells; Alkaline Phosphatase; Amphiregulin; Animals; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Genetic Markers; Glycoproteins; Heparin-binding EGF-like Growth Factor; Histone Deacetylase 6; Histone Deacetylases; Humans; Integrin-Binding Sialoprotein; Intercellular Signaling Peptides and Proteins; Mice; Neuregulin-1; Osteoblasts; Osteocalcin; Osteogenesis; Quinazolines; Signal Transduction; Sp7 Transcription Factor; Transcription Factors; Transcription, Genetic; Transforming Growth Factor alpha | 2011 |
Molecular imaging with 11C-PD153035 PET/CT predicts survival in non-small cell lung cancer treated with EGFR-TKI: a pilot study.
Topics: Aged; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Pilot Projects; Positron-Emission Tomography; Prospective Studies; Protein Kinase Inhibitors; Quinazolines; Radiopharmaceuticals; Tomography, X-Ray Computed; Treatment Outcome | 2011 |
Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line; Cetuximab; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Multiple; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Morpholines; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Signal Transduction; Tyrphostins | 2012 |
Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Becaplermin; Cell Division; Cyclooxygenase 2; Cytokines; Drug Evaluation, Preclinical; Endothelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Fibroblasts; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred DBA; Neovascularization, Pathologic; Osteoclasts; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Synovial Membrane | 2012 |
Therapeutic and preventive effects of an epidermal growth factor receptor inhibitor on oral squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cheek; Cricetinae; ErbB Receptors; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Quinazolines; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2012 |
Epidermal growth factor enhances MPC-83 pancreatic cancer cell migration through the upregulation of aquaporin 3.
Topics: Antineoplastic Agents; Aquaporin 3; Butadienes; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Nitriles; Pancreatic Neoplasms; Phosphorylation; Quinazolines; Up-Regulation | 2012 |
Gefitinib, but not erlotinib, is a possible inducer of Fra-1-mediated interstitial lung disease.
Topics: Animals; Antineoplastic Agents; Chemokine CCL2; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Gene Expression Regulation; Lipopolysaccharides; Lung Diseases, Interstitial; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Primary Cell Culture; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; Tumor Necrosis Factor-alpha | 2012 |
ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Male; Motor Activity; Quinazolines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Schizophrenic Psychology | 2013 |
Sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor requires E-cadherin in esophageal cancer and malignant pleural mesothelioma.
Topics: Biomarkers, Tumor; Cadherins; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; ErbB Receptors; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Quinazolines; Signal Transduction | 2013 |
Dynamic conformational transitions of the EGF receptor in living mammalian cells determined by FRET and fluorescence lifetime imaging microscopy.
Topics: Animals; Cell Membrane; CHO Cells; Cricetulus; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Models, Molecular; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins | 2013 |
Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Cell Line, Tumor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Probes; Positron-Emission Tomography; Quinazolines; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2013 |
Pb²⁺ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells.
Topics: Cell Line, Tumor; Environmental Pollutants; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Interleukin-8; Lead; Proto-Oncogene Proteins c-jun; Quinazolines; Stomach Neoplasms; Transcription Factor AP-1; Tyrphostins; Up-Regulation | 2015 |
Combined treatment with sodium butyrate and PD153035 enhances keratinocyte differentiation.
Topics: Antineoplastic Agents; Butyric Acid; Cell Differentiation; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Filaggrin Proteins; Histamine Antagonists; Humans; Intermediate Filament Proteins; Keratinocytes; Quinazolines; RNA, Messenger; Transglutaminases | 2014 |
Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells.
Topics: Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Neoplasms; Nitro Compounds; Oxadiazoles; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins | 2014 |
Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells.
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Epithelial Cells; ErbB Receptors; Female; Gene Expression; Humans; Mammary Glands, Human; Mitochondria; Plasminogen Inactivators; Quinazolines; Reactive Oxygen Species; Urokinase-Type Plasminogen Activator | 2015 |
Relevance of E-cadherin expression to EGFR-TKI molecular targeted therapy sensitivity/resistance and its clinical significance.
Topics: Breast Neoplasms; Cadherins; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Molecular Targeted Therapy; Protein Kinase Inhibitors; Quinazolines; Signal Transduction | 2015 |
Predictive efficacy of (11)C-PD153035 PET imaging for EGFR-tyrosine kinase inhibitor sensitivity in non-small cell lung cancer patients.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; Drug Resistance, Neoplasm; ErbB Receptors; Heterografts; Humans; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Nude; Multimodal Imaging; Positron-Emission Tomography; Protein Kinase Inhibitors; Quinazolines; Tomography, X-Ray Computed | 2016 |
Role of EGF receptor ligands in TCDD-induced EGFR down-regulation and cellular proliferation.
Topics: Amphiregulin; Cell Proliferation; Cells, Cultured; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Ligands; Polychlorinated Dibenzodioxins; Protein Binding; Quinazolines; Transforming Growth Factor alpha | 2016 |
Activation of AMP-activated kinase modulates sensitivity of glioma cells against epidermal growth factor receptor inhibition.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Glioma; Glucose; Glycolysis; Humans; Imatinib Mesylate; K562 Cells; Phosphorylation; Pyrones; Quinazolines; Thiophenes | 2016 |
Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Mice; Neoplasm Proteins; Quinazolines; Topotecan; Up-Regulation; Xenograft Model Antitumor Assays | 2018 |
Transcriptional repressor Kaiso promotes epithelial to mesenchymal transition and metastasis in prostate cancer through direct regulation of miR-200c.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Epidermal Growth Factor; Epithelial-Mesenchymal Transition; ErbB Receptors; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Neoplasm Transplantation; Prostatic Neoplasms; Quinazolines; Transcription Factors | 2018 |
ERK1/2-mediated EGFR-signaling is required for TGFβ-induced lens epithelial-mesenchymal transition.
Topics: Actins; Animals; beta Catenin; Blotting, Western; Cell Movement; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Lens, Crystalline; MAP Kinase Signaling System; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta2 | 2019 |
Weak power frequency magnetic fields induce microtubule cytoskeleton reorganization depending on the epidermal growth factor receptor and the calcium related signaling.
Topics: Calcium; Calcium Channels, L-Type; Calcium Signaling; Cell Line; Electromagnetic Fields; Enzyme Inhibitors; ErbB Receptors; Humans; Intracellular Space; Microtubules; Phosphorylation; Quinazolines | 2018 |
Epidermal growth factor receptor inhibition attenuates non-alcoholic fatty liver disease in diet-induced obese mice.
Topics: Animals; Cell Line, Tumor; Diabetes Mellitus, Experimental; Dietary Fats; ErbB Receptors; Humans; Lipogenesis; Male; Mice; Non-alcoholic Fatty Liver Disease; Quinazolines; Signal Transduction | 2019 |
Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium.
Topics: CDX2 Transcription Factor; Cell Differentiation; Cells, Cultured; Dextrans; Endoderm; ErbB Receptors; Fibroblast Growth Factor 10; Fluorescein-5-isothiocyanate; Glycogen Synthase Kinase 3 beta; Humans; Induced Pluripotent Stem Cells; Permeability; PPAR gamma; Pyridines; Pyrimidines; Quinazolines; Recombinant Proteins; Regenerative Medicine; SOXF Transcription Factors; Troglitazone; Urinary Bladder; Uroplakins; Urothelium | 2019 |
Scratch wound-induced CXCL8 upregulation is EGFR-dependent in keratinocytes.
Topics: Cell Movement; Cells, Cultured; ErbB Receptors; Humans; Interleukin-8; Keratinocytes; Quinazolines; Up-Regulation; Wound Healing | 2020 |
Activation of PPARγ and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells.
Topics: Animals; Arsenites; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Down-Regulation; ErbB Receptors; Hepatocyte Nuclear Factor 3-alpha; Humans; Keratins; Mice; Mice, Nude; PPAR gamma; Quinazolines; Transcription Factors; Transcriptome; Transplantation, Heterologous; Troglitazone; Up-Regulation; Urinary Bladder Neoplasms | 2020 |