Compounds > quinazolines
Page last updated: 2024-08-21

quinazolines and nu 1025

quinazolines has been researched along with nu 1025 in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (10.71)18.2507
2000's12 (42.86)29.6817
2010's11 (39.29)24.3611
2020's2 (7.14)2.80

Authors

AuthorsStudies
Bowman, KJ; Curtin, NJ; Golding, BT; Griffin, RJ; White, A1
Bowman, K; Calvert, AH; Curtin, NJ; Golding, BT; Griffin, RJ; Newell, DR; Pemberton, LC; Srinivasan, S1
Boulton, S; Durkacz, BW; Kyle, S1
Calvert, AH; Curtin, NJ; Delaney, CA; Durkacz, BW; Hostomsky, Z; Kyle, S; Newell, DR; Wang, LZ; White, AW1
Bowman, KJ; Calvert, AH; Curtin, NJ; Newell, DR1
Bonmassar, E; d'Amati, G; Graziani, G; Leonetti, C; Portarena, I; Scarsella, M; Tentori, L; Zupi, G1
Chalmers, A; Johnston, P; Joiner, M; Marples, B; Woodcock, M1
Gallmeier, E; Kern, SE1
Haince, JF; Hendzel, MJ; Masson, JY; Poirier, GG; Rouleau, M1
Ding, J; Geng, MY; Meng, LH; Miao, ZH1
Kaundal, RK; Shah, KK; Sharma, SS1
Chianese, M; Cimmino, G; Laus, G; Penitente, R; Pepe, S; Prece, D; Quesada, P1
Bentzen, SM; Buffa, FM; Chalmers, AJ1
Curtin, NJ; Kyle, S; Mitchell, J; Thomas, HD1
Cieślar-Pobuda, A; Ryabokon, NI; Rzeszowska-Wolny, J1
Sabisz, M; Skladanowski, A; Wesierska-Gadek, J1
Bradshaw, TD; Laughton, CA; Madhusudan, S; Stevens, MF; Zhang, J1
Aten, JA; Buist, MR; Eppink, B; Essers, J; Franken, NA; Kanaar, R; Krawczyk, PM; O'Connor, MJ; Odijk, H; Rens, J; Rodermond, H; Soullié, T; Stalpers, LJ; Stap, J; Ten Hagen, TL; van Bree, C; Verhagen, HJ; Zelensky, A1
Kachnic, LA; Powell, SN1
Cieślar-Pobuda, A; Rzeszowska-Wolny, J; Saenko, Y1
Chiou, TT; Gallacchi, D; Kwiatkowski, DJ; Lee, PS; Li, C; Malinowska, IA; Pereira, AM; Reynolds, SB; Robinson, L; Sun, Y; Yu, JJ; Zhang, EY1
Carlomagno, C; Della Vittoria Scarpati, G; Ferrone, S; Fusciello, C; Leonardi, A; Pacelli, R; Pepe, S; Pepin, D; Poudel, R; Sabbatino, F; Somma, D1
Battaile, KP; Beletskaya, I; Chirgadze, NY; Gebremeskel, S; Gordon, R; Lam, R; Pai, EF; Qiu, W; Romanov, V; Rottapel, R; Thompson, C; Vodsedalek, J; Voytyuk, O1
Cupo, M; Mauritz, M; Mitulovic, G; Węsierska-Gądek, J1
Gunn, AR; Kolb, AL; Lakin, ND1
Dickson, BD; Hay, MP; Wilson, WR; Wong, WW1
Karamouzis, MV; Koustas, E; Papavassiliou, AG; Sarantis, P; Schizas, D1
Godoy, PRDV; Lima, SCG; Montaldi, AP; Sakamoto-Hojo, ET; Xavier, DJ1

Reviews

2 review(s) available for quinazolines and nu 1025

ArticleYear
Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy.
    Trends in molecular medicine, 2005, Volume: 11, Issue:10

    Topics: DNA Repair; Gene Components; Heterocyclic Compounds, 4 or More Rings; Humans; Indoles; Models, Molecular; Neoplasms; Phenanthrenes; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Quinazolinones; Signal Transduction

2005
Emerging cancer therapeutic opportunities target DNA-repair systems.
    Trends in pharmacological sciences, 2006, Volume: 27, Issue:6

    Topics: Animals; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Neoplasm; Drug Resistance, Neoplasm; Guanine; Humans; Morpholines; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Pyrones; Quinazolines; Signal Transduction; Tumor Suppressor Proteins

2006

Other Studies

26 other study(ies) available for quinazolines and nu 1025

ArticleYear
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.
    British journal of cancer, 1998, Volume: 78, Issue:10

    Topics: Amides; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzimidazoles; Bleomycin; Cell Death; Dacarbazine; DNA Damage; DNA Methylation; DNA Repair; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Gamma Rays; Leukemia L1210; Mice; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Tumor Cells, Cultured

1998
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
    Journal of medicinal chemistry, 1998, Dec-17, Volume: 41, Issue:26

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cell Survival; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Gamma Rays; Leukemia L1210; Mice; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured

1998
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage.
    Carcinogenesis, 1999, Volume: 20, Issue:2

    Topics: Androstadienes; Animals; Antineoplastic Agents; Cell Survival; CHO Cells; Cricetinae; Dacarbazine; DNA; DNA Damage; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; DNA, Single-Stranded; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Quinazolines; Temozolomide; Wortmannin

1999
Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:7

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Survival; Colonic Neoplasms; Dacarbazine; Drug Synergism; Enzyme Inhibitors; Female; Humans; Lung Neoplasms; Ovarian Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Temozolomide; Topotecan; Tumor Cells, Cultured; Tumor Stem Cell Assay

2000
Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro.
    British journal of cancer, 2001, Jan-05, Volume: 84, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; DNA Damage; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Etoposide; Leukemia L1210; Nucleic Acid Synthesis Inhibitors; Proteins; Quinazolines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2001
Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site.
    Blood, 2002, Mar-15, Volume: 99, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Dacarbazine; Drug Evaluation, Preclinical; Hematologic Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Survival Analysis; Survival Rate; Temozolomide

2002
PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation.
    International journal of radiation oncology, biology, physics, 2004, Feb-01, Volume: 58, Issue:2

    Topics: Animals; Benzamides; Cell Line; Cell Line, Tumor; Cell Survival; Cricetinae; Enzyme Inhibitors; Humans; Mice; Phenanthrenes; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Radiation Dosage; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Stem Cell Assay

2004
Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition.
    Cancer biology & therapy, 2005, Volume: 4, Issue:7

    Topics: Adenocarcinoma; Apoptosis; Benzamides; BRCA2 Protein; Enzyme Inhibitors; Frameshift Mutation; Humans; Pancreatic Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Tumor Cells, Cultured; Tumor Stem Cell Assay

2005
Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.
    Life sciences, 2006, Nov-10, Volume: 79, Issue:24

    Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Survival; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Hydrogen Peroxide; Male; Middle Cerebral Artery; Molsidomine; NAD; Neuroprotective Agents; PC12 Cells; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2006
Poly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54(p53wt) and U251(p53mut) glioblastoma cell lines.
    Pharmacological research, 2007, Volume: 55, Issue:1

    Topics: Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Densitometry; DNA Damage; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Glioblastoma; Humans; In Situ Nick-End Labeling; Indicators and Reagents; Mutation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Quinazolines; Signal Transduction; Topotecan; Tumor Suppressor Protein p53

2007
A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose.
    Theoretical biology & medical modelling, 2007, Jul-19, Volume: 4

    Topics: Animals; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cricetulus; DNA Repair; Dose-Response Relationship, Radiation; Humans; Quinazolines

2007
Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.
    The British journal of radiology, 2008, Volume: 81 Spec No 1

    Topics: Animals; Azulenes; Benzodiazepines; BRCA2 Protein; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; Enzyme Inhibitors; Female; Mice; Mice, Nude; Neoplasms, Experimental; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Recombination, Genetic

2008
Inhibition of poly(ADP-ribose) polymerase activity affects its subcellular localization and DNA strand break rejoining.
    Acta biochimica Polonica, 2009, Volume: 56, Issue:2

    Topics: Cell Line, Tumor; Cell Nucleus; Coumarins; DNA Breaks; DNA Repair; Enzyme Inhibitors; Humans; Isoquinolines; K562 Cells; Kinetics; Microscopy, Fluorescence; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Transport; Quinazolines; Quinolines

2009
Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints.
    Biochemical pharmacology, 2010, May-15, Volume: 79, Issue:10

    Topics: Acridines; Apoptosis; Blotting, Western; Cell Cycle; Cell Death; Cyclin B1; DNA Damage; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Gene Expression Regulation; HeLa Cells; Humans; Mitosis; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Polyploidy; Proteasome Endopeptidase Complex; Quinazolines; Topoisomerase II Inhibitors; Triazoles; Tumor Suppressor Protein p53

2010
Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications.
    Oncology, 2010, Volume: 78, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Cell Cycle; Cell Line, Tumor; Dacarbazine; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Flow Cytometry; Glioblastoma; Glioma; Humans; Nitrogen Mustard Compounds; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotide Array Sequence Analysis; Quinazolines; Temozolomide; Tumor Stem Cell Assay

2010
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Jun-14, Volume: 108, Issue:24

    Topics: Animals; Benzoquinones; BRCA2 Protein; Cell Line; Cell Line, Tumor; Cells, Cultured; DNA Repair; DNA-Binding Proteins; Embryonic Stem Cells; Female; HeLa Cells; Hot Temperature; Humans; Immunoblotting; Lactams, Macrocyclic; Mice; Mice, Nude; Neoplasms, Experimental; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Rats; Recombination, Genetic; RNA Interference; Transplantation, Heterologous; Tumor Burden

2011
Homologous recombination research is heating up and ready for therapy.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Jun-14, Volume: 108, Issue:24

    Topics: Animals; Benzoquinones; BRCA2 Protein; Cell Line, Tumor; DNA Repair; DNA-Binding Proteins; Hot Temperature; Humans; Immunoblotting; Lactams, Macrocyclic; Mice; Neoplasms, Experimental; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Rats; Recombination, Genetic; RNA Interference; Transplantation, Heterologous; Tumor Burden

2011
PARP-1 inhibition induces a late increase in the level of reactive oxygen species in cells after ionizing radiation.
    Mutation research, 2012, Apr-01, Volume: 732, Issue:1-2

    Topics: Apoptosis; Coumarins; DNA Breaks, Double-Stranded; DNA Repair; G2 Phase Cell Cycle Checkpoints; Humans; Isoquinolines; K562 Cells; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Reactive Oxygen Species; X-Rays

2012
Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis.
    American journal of respiratory cell and molecular biology, 2014, Volume: 51, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Line; DNA Repair; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Enzymologic; Humans; Isoquinolines; Lung Neoplasms; Lymphangioleiomyomatosis; Mice, Inbred C57BL; Mice, SCID; Molecular Targeted Therapy; Phthalazines; Piperazines; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Rats; Sirolimus; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Up-Regulation; Xenograft Model Antitumor Assays

2014
Effect of p53 activity on the sensitivity of human glioblastoma cells to PARP-1 inhibitor in combination with topoisomerase I inhibitor or radiation.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2014, Volume: 85, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; DNA Damage; DNA Repair; DNA Topoisomerases, Type I; Flow Cytometry; Glioblastoma; Humans; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Radiation, Ionizing; Topoisomerase I Inhibitors; Topotecan; Tumor Suppressor Protein p53

2014
Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
    Acta crystallographica. Section D, Biological crystallography, 2014, Volume: 70, Issue:Pt 10

    Topics: Benzamides; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Protein Conformation; Pyrimidinones; Quinazolines; Tankyrases

2014
Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells.
    Journal of cellular biochemistry, 2015, Volume: 116, Issue:12

    Topics: Apoptosis; Benzamides; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Indoles; Phthalazines; Piperazines; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines

2015
Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium.
    Nucleic acids research, 2017, Sep-29, Volume: 45, Issue:17

    Topics: ADP Ribose Transferases; Benzamides; Clone Cells; Cyclin-Dependent Kinase 8; Dictyostelium; DNA Damage; Drug Resistance; Exodeoxyribonucleases; Gene Deletion; Homologous Recombination; Indoles; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protozoan Proteins; Quinazolines; Rad51 Recombinase; Recombinant Proteins

2017
Studies Towards Hypoxia-Activated Prodrugs of PARP Inhibitors.
    Molecules (Basel, Switzerland), 2019, Apr-19, Volume: 24, Issue:8

    Topics: Antineoplastic Agents; Chromatography, Liquid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Poly(ADP-ribose) Polymerase Inhibitors; Prodrugs; Quinazolines

2019
Inhibition of c-MET increases the antitumour activity of PARP inhibitors in gastric cancer models.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:18

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Clone Cells; DNA Damage; Histones; Humans; Indoles; Mice; Models, Biological; Neoplasm Proteins; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-met; Quinazolines; Stomach Neoplasms; Sulfonamides; Xenograft Model Antitumor Assays

2020
PARP‑1 inhibition sensitizes temozolomide‑treated glioblastoma cell lines and decreases drug resistance independent of MGMT activity and PTEN proficiency.
    Oncology reports, 2020, Volume: 44, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioblastoma; Humans; Mutation; Poly (ADP-Ribose) Polymerase-1; PTEN Phosphohydrolase; Quinazolines; Temozolomide; Tumor Suppressor Proteins

2020