quinazolines has been researched along with leucine in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cantley, LG; Kjelsberg, CA; Nigam, SK; Sakurai, H; Tsukamoto, T | 1 |
| Finer-Moore, JS; Fritz, TA; Liu, L; Stroud, RM | 1 |
| Choi, JI; Jeong, SW; Yoon, MH | 1 |
| Fukuhara, T; Inoue, A; Kimura, Y; Maemondo, M; Morikawa, N; Nukiwa, T; Saijo, Y; Suzuki, T; Watanabe, H | 1 |
| Asahina, H; Dosaka-Akita, H; Kinoshita, I; Nishimura, M; Yamazaki, K; Yokouchi, H | 1 |
| Fukui, T; Furuta, K; Kunitoh, H; Matsuno, Y; Nokihara, H; Ohe, Y; Sakamoto, H; Sekine, I; Takano, T; Tamura, T; Tateishi, U; Tsuta, K; Yamamoto, N; Yoshida, T | 1 |
| Lin, R; Ling, YH; Perez-Soler, R | 1 |
| Imai, H; Ishizuka, T; Kaira, K; Kanai, Y; Mori, M; Nagamori, S; Nakajima, T; Oriuchi, N; Promchan, K; Shimizu, K; Sunaga, N; Tominaga, H; Yamamoto, N; Yanagitani, N | 1 |
| Chan, KS; Lim, KH; Lim, WT; Lynette, O; Montoya, J; Ng, QS; Sakktee Krisna, S; Takano, A; Tan, DS; Tan, EH | 1 |
| Giddings, AM; Gilmour, BP; Harris, DL; Longpre, JM; Narayanan, S; Olepu, S; Runyon, SP; Sarret, P; Thomas, JB; Warner, KR; Wiethe, RW | 1 |
| Bhatt, JD; Chudasama, CJ; Dixit, BC; Dixit, RB; Patel, BD; Patel, TS | 1 |
1 trial(s) available for quinazolines and leucine
| Article | Year |
|---|---|
Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Arginine; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; ErbB Receptors; Feasibility Studies; Female; Gefitinib; Glutamic Acid; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Staging; Positron-Emission Tomography; Prospective Studies; Quinazolines; Treatment Outcome | 2006 |
10 other study(ies) available for quinazolines and leucine
| Article | Year |
|---|---|
EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney.
Topics: Animals; Aprotinin; Cell Line; Coculture Techniques; Collagen; Cysteine Proteinase Inhibitors; Embryonic Induction; Enzyme Inhibitors; Epithelium; ErbB Receptors; Hepatocyte Growth Factor; Kidney; Kidney Medulla; Kidney Tubules, Collecting; Leucine; Ligands; Mice; Mice, Knockout; Morphogenesis; Nitriles; Phenanthrolines; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Quinazolines; Receptor Protein-Tyrosine Kinases; Transforming Growth Factor alpha; Tyrphostins | 1997 |
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Topics: Binding Sites; Biological Transport; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Leucine; Models, Chemical; Point Mutation; Protons; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Tryptophan | 2002 |
Spinal gabapentin and antinociception: mechanisms of action.
Topics: Acetates; Adrenergic alpha-Antagonists; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amines; Analgesics; Animals; Atropine; Cyclohexanecarboxylic Acids; Dihydroergocristine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Injections, Spinal; Leucine; Male; Mecamylamine; Muscarinic Antagonists; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nicotinic Antagonists; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Serine; Spinal Cord; Thapsigargin; Triazoles | 2003 |
Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.
Topics: Adenocarcinoma; DNA, Neoplasm; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Isoleucine; Leucine; Lung Neoplasms; Male; Middle Aged; Mutation; Quinazolines; Serine; Valine | 2006 |
Epidermal growth factor receptor mutation detection using high-resolution melting analysis predicts outcomes in patients with advanced non small cell lung cancer treated with gefitinib.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Antineoplastic Agents; Arginine; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; DNA Mutational Analysis; ErbB Receptors; Female; Gefitinib; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Mutation; Prognosis; Quinazolines; Survival Analysis; Treatment Outcome | 2007 |
Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptorL858R mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK.
Topics: Amino Acid Substitution; Apoptosis; Arginine; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Caspase Inhibitors; Cell Line, Tumor; Down-Regulation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Humans; Leucine; Lung Neoplasms; Mitochondria; Mutation; Oxidative Phosphorylation; Protein Structure, Quaternary; Protein Transport; Quinazolines; Reactive Oxygen Species; RNA, Small Interfering | 2008 |
Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids, Cyclic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Growth Processes; Cell Line, Tumor; ErbB Receptors; Fusion Regulatory Protein-1; Gefitinib; Humans; Immunohistochemistry; Large Neutral Amino Acid-Transporter 1; Leucine; Lung Neoplasms; Middle Aged; Mutation; Quinazolines; RNA, Messenger; TOR Serine-Threonine Kinases | 2010 |
Molecular profiling for druggable genetic abnormalities in carcinoma of unknown primary.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arginine; Biopsy; Carboplatin; Carcinoma; Deoxycytidine; Disease-Free Survival; ErbB Receptors; Gefitinib; Gemcitabine; Humans; Immunohistochemistry; Leucine; Male; Middle Aged; Molecular Targeted Therapy; Neoplasm Staging; Neoplasms, Unknown Primary; Point Mutation; Quinazolines; Tomography, X-Ray Computed | 2013 |
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.
Topics: Calcium; Drug Partial Agonism; Humans; Leucine; Models, Molecular; Molecular Structure; Quinazolines; Radioligand Assay; Receptors, Neurotensin; Structure-Activity Relationship | 2015 |
Design and synthesis of leucine-linked quinazoline-4(3H)-one-sulphonamide molecules distorting malarial reductase activity in the folate pathway.
Topics: Animals; Antimalarials; Cell Survival; Chlorocebus aethiops; Drug Design; Folic Acid; Folic Acid Antagonists; Inhibitory Concentration 50; Leucine; Molecular Docking Simulation; Molecular Structure; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Quinazolines; Sulfonamides; Vero Cells | 2019 |