Page last updated: 2024-08-21

quinazolines and krn 633

quinazolines has been researched along with krn 633 in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.88)29.6817
2010's13 (76.47)24.3611
2020's3 (17.65)2.80

Authors

AuthorsStudies
Matsunaga, N; Nakamura, K; Taguchi, E; Takahashi, K; Tsunoda, H; Yamamoto, A1
Abe, N; Ishii, K; Nagamitsu, T; Nakahara, T; Ohta, H; Ozaki, H; Wada, Y1
Ban, HS; Nakamura, H; Uno, M1
Abe, N; Ishii, K; Mori, A; Nagamitsu, T; Nakahara, T; Ozaki, H; Sakamoto, K; Wada, Y1
Abe, N; Ishii, K; Mori, A; Morita, A; Nagamitsu, T; Nakahara, T; Sakamoto, K; Wada, Y1
Abe, N; Ishii, K; Kurauchi, Y; Mori, A; Morita, A; Nagamitsu, T; Nakahara, T; Sakamoto, K2
Asano, D; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K1
Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Yagasaki, R1
Ishii, K; Mori, A; Nakahara, T; Nakano, A; Sakamoto, K; Ushikubo, H1
Arima, S; Ishii, K; Mori, A; Morita, A; Nagamitsu, T; Nakahara, T; Sakamoto, K; Ushikubo, H1
Arima, S; Ishii, K; Mori, A; Morita, A; Nagamitsu, T; Nakahara, T; Sakamoto, K1
Arima, S; Asano, D; Ishii, K; Kondo, R; Mori, A; Nagamitsu, T; Nakahara, T; Nakano, A; Sakamoto, K; Ushikubo, H1
Arima, S; Mori, A; Morita, A; Nagamitsu, T; Nakahara, T; Sakamoto, K; Sawada, S1
Arima, S; Asano, D; Kaneko, Y; Kondo, R; Morita, A; Nagamitsu, T; Nakahara, T; Nakano, A; Sakamoto, K1
Arima, S; Asano, D; Kondo, R; Mori, A; Morita, A; Nagamitsu, T; Nakahara, T; Nakano, A; Sakamoto, K1
Arima, S; Mori, A; Morita, A; Nagamitsu, T; Nakahara, T; Sakamoto, K; Yoshizumi, M1

Other Studies

17 other study(ies) available for quinazolines and krn 633

ArticleYear
Improvement by solid dispersion of the bioavailability of KRN633, a selective inhibitor of VEGF receptor-2 tyrosine kinase, and identification of its potential therapeutic window.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Blood Vessels; Body Weight; Crystallization; Drug Compounding; Drug Stability; Humans; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Phenylurea Compounds; Quinazolines; Rats; Rats, Sprague-Dawley; Solubility; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2006
Effects of KRN633, an inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase, on vascular development of placenta and fetus of mid-pregnancy in mice.
    Journal of pharmacological sciences, 2010, Volume: 112, Issue:3

    Topics: Animals; Female; Fetal Growth Retardation; Fetus; Mice; Mice, Inbred ICR; Phenylurea Compounds; Placenta; Pregnancy; Pregnancy Trimester, Second; Protein Kinase Inhibitors; Quinazolines; Vascular Endothelial Growth Factor Receptor-2

2010
Suppression of hypoxia-induced HIF-1alpha accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633.
    Cancer letters, 2010, Oct-01, Volume: 296, Issue:1

    Topics: Angiogenesis Inhibitors; Cell Culture Techniques; Cell Line, Tumor; Colorectal Neoplasms; DNA Primers; DNA-Directed DNA Polymerase; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Indoles; Phenylurea Compounds; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Vascular Endothelial Growth Factor A

2010
Role of vascular endothelial growth factor in maintenance of pregnancy in mice.
    Endocrinology, 2013, Volume: 154, Issue:2

    Topics: Animals; Corpus Luteum; Female; Mice; Mice, Inbred ICR; Parturition; Phenylurea Compounds; Pregnancy; Progesterone; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A

2013
KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, induces intrauterine growth restriction in mice.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2013, Volume: 98, Issue:4

    Topics: Animals; Animals, Newborn; Female; Fetal Growth Retardation; Intestine, Small; Kidney; Lymphoid Tissue; Male; Mice; Pancreas; Phenylurea Compounds; Placenta; Pregnancy; Protein Kinase Inhibitors; Quinazolines; Receptors, Vascular Endothelial Growth Factor

2013
Effects of pre- and post-natal treatment with KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, on retinal vascular development and patterning in mice.
    Experimental eye research, 2014, Volume: 120

    Topics: Administration, Oral; Animals; Animals, Newborn; Female; Fluorescein Angiography; Fluorescent Antibody Technique, Indirect; In Situ Hybridization; Male; Mice; Mice, Inbred ICR; Phenylurea Compounds; Platelet Endothelial Cell Adhesion Molecule-1; Pregnancy; Prenatal Exposure Delayed Effects; Quinazolines; Retinal Neovascularization; Retinal Vessels; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2014
Treatment of mid-pregnant mice with KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, induces abnormal retinal vascular patterning in their newborn pups.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2014, Volume: 101, Issue:4

    Topics: Animals; Animals, Newborn; Female; Fetal Growth Retardation; Mice; Mice, Inbred ICR; Neovascularization, Physiologic; Phenylurea Compounds; Pregnancy; Quinazolines; Receptor, Platelet-Derived Growth Factor beta; Receptors, Vascular Endothelial Growth Factor; Retinal Vessels

2014
Regression of retinal capillaries following N-methyl-D-aspartate-induced neurotoxicity in the neonatal rat retina.
    Journal of neuroscience research, 2015, Volume: 93, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Capillaries; Collagen Type IV; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Male; N-Methylaspartate; Neurotoxicity Syndromes; Phenylurea Compounds; Plant Lectins; Quinazolines; Rats; Rats, Sprague-Dawley; Rec A Recombinases; Retinal Degeneration; Statistics, Nonparametric; Vascular Endothelial Growth Factor A

2015
Effects of mTOR inhibition on normal retinal vascular development in the mouse.
    Experimental eye research, 2014, Volume: 129

    Topics: Animals; Cell Count; Cell Growth Processes; Endothelium, Vascular; Female; Male; Mice; Phenylurea Compounds; Quinazolines; Retinal Vessels; Sirolimus; TOR Serine-Threonine Kinases

2014
Short-term treatment with VEGF receptor inhibitors induces retinopathy of prematurity-like abnormal vascular growth in neonatal rats.
    Experimental eye research, 2016, Volume: 143

    Topics: Animals; Animals, Newborn; Axitinib; Disease Models, Animal; Female; Fluorescent Antibody Technique, Indirect; Imidazoles; Indazoles; Microscopy, Fluorescence; Phenylurea Compounds; Pregnancy; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2016
A delay in vascularization induces abnormal astrocyte proliferation and migration in the mouse retina.
    Developmental dynamics : an official publication of the American Association of Anatomists, 2017, Volume: 246, Issue:3

    Topics: Animals; Astrocytes; Cell Movement; Cell Proliferation; Endothelial Cells; Female; Hypoxia; Immunohistochemistry; In Situ Hybridization; Male; Mice; Phenylurea Compounds; Pregnancy; Quinazolines; Retina; Vascular Endothelial Growth Factor A

2017
Transient phenotypic changes in endothelial cells and pericytes in neonatal mouse retina following short-term blockade of vascular endothelial growth factor receptors.
    Developmental dynamics : an official publication of the American Association of Anatomists, 2018, Volume: 247, Issue:5

    Topics: Animals; Animals, Newborn; Cell Proliferation; Female; Immunohistochemistry; Male; Mice; Pericytes; Phenylurea Compounds; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Retina; Vascular Endothelial Growth Factor A

2018
Retinal neuronal cell loss prevents abnormal retinal vascular growth in a rat model of retinopathy of prematurity.
    Experimental eye research, 2018, Volume: 168

    Topics: Animals; Capillaries; Cell Proliferation; Disease Models, Animal; N-Methylaspartate; Phenylurea Compounds; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Retinal Neurons; Retinal Vessels; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A

2018
Establishment of an abnormal vascular patterning model in the mouse retina.
    Journal of pharmacological sciences, 2018, Volume: 136, Issue:4

    Topics: Animals; Animals, Newborn; Choroid; Disease Models, Animal; Electroretinography; Female; Ischemia; Male; Mice, Inbred ICR; Phenylurea Compounds; Quinazolines; Retina; Retinal Vessels; Signal Transduction; Time Factors; Vascular Endothelial Growth Factor A

2018
Changes in components of the neurovascular unit in the retina in a rat model of retinopathy of prematurity.
    Cell and tissue research, 2020, Volume: 379, Issue:3

    Topics: Animals; Disease Models, Animal; Female; Phenylurea Compounds; Pregnancy; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Retina; Retinal Neovascularization; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A

2020
Abnormal Vascular Phenotypes Associated with the Timing of Interruption of Retinal Vascular Development in Rats.
    Biological & pharmaceutical bulletin, 2020, Volume: 43, Issue:5

    Topics: Animals; Animals, Newborn; Phenotype; Phenylurea Compounds; Protein Kinase Inhibitors; Quinazolines; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Retinal Vessels; Time Factors

2020
Pharmacological depletion of retinal neurons prevents vertical angiogenic sprouting without affecting the superficial vascular plexus.
    Developmental dynamics : an official publication of the American Association of Anatomists, 2021, Volume: 250, Issue:4

    Topics: Animals; Astrocytes; Female; Male; Mice, Inbred ICR; N-Methylaspartate; Neovascularization, Physiologic; Phenylurea Compounds; Quinazolines; Retina

2021