quinazolines has been researched along with ic 87114 in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (20.00) | 29.6817 |
| 2010's | 39 (70.91) | 24.3611 |
| 2020's | 5 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Dick, K; Sadhu, C; Staunton, DE; Tino, WT | 1 |
| Hayflick, JS; Northcott, CA; Watts, SW | 1 |
| Hayflick, J; Northcott, CA; Watts, SW | 1 |
| Hayflick, JS; Lee, HK; Lee, KS; Lee, YC; Puri, KD | 1 |
| Billottet, C; Gale, RE; Grandage, VL; Khwaja, A; Quattropani, A; Rommel, C; Vanhaesebroeck, B | 1 |
| Ferreira, AM; Hayflick, JS; Isaacs, H; Rogers, KA; Sandig, M | 1 |
| Jin, SM; Kim, SR; Lee, KS; Lee, YC; Min, KH; Park, SJ; Puri, KD | 1 |
| Blagbrough, IS; Farghaly, HS; Medina-Tato, DA; Watson, ML | 1 |
| Diacovo, TG; Puri, KD; Randis, TM; Zhou, H | 1 |
| Andina, N; Dahinden, CA; Didichenko, S; Schmidt-Mende, J; Simon, HU | 1 |
| Durand, CA; Fogelstrand, L; Gold, MR; Hartvigsen, K; Iritani, S; Kim, S; Puri, KD; Vanhaesebroeck, B; Witztum, JL | 1 |
| Bjørgo, E; Bunyard, P; Clark, J; Dale, VQ; Galleway, F; Gaston, JS; Moltu, K; Okkenhaug, K; Patton, DT; Soond, DR; Taskén, K; Torgersen, KM; Twomey, B | 1 |
| Adcock, IM; Barnes, PJ; Elliott, WM; Failla, M; Hogg, JC; Ito, K; Ito, M; Kizawa, Y; Kusama, T; To, Y | 1 |
| Abdel-Tawab, H; Ahmed, EA; Alhazza, IM; Badr, G; Hassan, K; Saad, H; Waly, H | 1 |
| Chung, CR; Han, HJ; Kim, SR; Lee, KS; Lee, MH; Lee, YC; Min, KH; Moon, H; Park, SJ; Puri, KD | 1 |
| Knight, ZA | 1 |
| Hart, JR; Hillmann, P; Hofmann, BT; Sun, M; Vogt, PK | 1 |
| Kim, SR; Lee, KS; Lee, YC; Min, KH; Moon, H; Park, HS; Park, SJ; Puri, KD | 1 |
| Cantrell, DA; Feijoo, C; Finlay, D; Macintyre, AN; Okkenhaug, K; Preston, G; Sinclair, LV; Tamas, P; Waugh, CM | 1 |
| Black, JL; Burgess, JK; Ge, Q; Moir, LM; Oliver, BG; Shepherd, PR; Trian, T | 1 |
| Okkenhaug, K; Patton, DT; Rowan, WC; Soond, DR; Wilson, MD | 1 |
| Black, JL; Burgess, JK; Ge, Q; Moir, LM; Niimi, K; Oliver, BG; Poniris, M; Shepherd, PR; Trian, T | 1 |
| Barnes, PJ; Ito, K; Ito, M; Osoata, G; Rossios, C; To, Y | 1 |
| Andreou, M; Makrigiannakis, A; Papakonstanti, EA; Stratigi, K; Tzenaki, N; Vanhaesebroeck, B; Vergetaki, A | 1 |
| Bahaie, NS; Blumenthal, MN; Ge, XN; Greenberg, Y; Ha, SG; Kang, BN; Puri, KD; Rao, SP; Reza Hosseinkhani, M; Sriramarao, P | 1 |
| Fu, H; Marelli-Berg, FM; McCormack, AM; Okkenhaug, K; Rose, ML; Sarathchandra, P; Ying, H | 1 |
| Besterman, AD; Harrison, PJ; Huang, W; Hyde, TM; Kleinman, JE; Law, AJ; Lipska, BK; O'Donnell, P; Papaleo, F; Piantadosi, P; Sei, Y; Straub, RE; Thomas, CJ; Vakkalanka, R; Wang, Y; Weinberger, DR | 1 |
| Rico, B | 1 |
| Cain, RJ; Ridley, AJ; Vanhaesebroeck, B | 1 |
| Brenker, K; Choi, K; Durand, CA; Gold, MR; Graves, M; Horwitz, MS; Puri, KD; Richer, MJ; Shanina, I | 1 |
| Mukkanti, K; Thappali, SR; Vakkalanka, SK; Varanasi, KV; Veeraraghavan, S | 1 |
| Dharmarajan, S; Dinavahi, SS; Nyayapathy, S; Perumal, Y; Viswanadha, S | 1 |
| Dixon, SJ; Jirik, FR; Kashishian, A; Lannutti, BJ; Pereverzev, A; Puri, KD; Shugg, RP; Sims, SM; Steiner, BH; Tanabe, N; Thomson, A | 1 |
| Hellman, U; Kazi, JU; Lundby, A; Mohlin, S; Olsen, JV; Påhlman, S; Rönnstrand, L; Sun, J | 1 |
| Bhandary, B; Chae, HJ; Kim, SR; Lee, YC; Marahatta, A | 1 |
| Cao, B; Hou, T; Li, D; Li, Y; Mao, X; Pan, P; Wang, M; Zhu, J | 1 |
| Liu, C; Wang, Y; Wei, P; Zhang, H; Zhang, L | 1 |
| Eräsalo, H; Hämäläinen, M; Laavola, M; Leppänen, T; Moilanen, E; Nieminen, R | 1 |
| Gu, Q; Gui, Y; He, X; Lan, T; Li, W; Qi, C; Tang, F; Wang, L; Wu, T; Xing, L; Yang, Y; Zeng, C; Zhang, Q; Zheng, L | 1 |
| Blanco, B; Del Cañizo, MC; Herrero-Sánchez, MC; Rodríguez-Serrano, C; Sánchez-Barba, M | 1 |
| Cho, SH; Jeong, JS; Kim, SR; Ko, YH; Kolliputi, N; Lee, KB; Lee, KS; Lee, YC; Park, HJ; Park, SC | 1 |
| Aiuti, A; Ariganello, P; Attardi, E; Brigida, I; Cancrini, C; Chiriaco, M; Cittaro, D; Di Cesare, S; Di Matteo, G; Finocchi, A; Fraziano, M; Giannelli, S; Lazarevic, D; Palma, P; Rossi, P; Santilli, V; Scarselli, A; Stupka, E; Taus, F | 1 |
| Bassell, GJ; Gross, C; Horn, PS; Poopal, AC; Schroeder, LM | 1 |
| Barbera Betancourt, A; Cooke, A; Emery, JL; Okkenhaug, K; Recino, A; Wallberg, M; Wong, FS | 1 |
| Feiz Barazandeh, A; Jia, P; Keynan, Y; Khadem, F; Liu, D; Mou, Z; Uzonna, JE | 1 |
| Bertolini, S; Biagetti, M; Capacchi, S; Capelli, AM; Corsi, M; Facchinetti, F; Gallo, PM; Lodola, A; Mor, M; Pala, D; Pappani, A; Rivara, S; Visentini, F | 1 |
| Gao, B; Guo, L; Hao, S; Jiang, Y; Luo, D; Tian, W; Yan, J; Zhang, S; Zhang, X | 1 |
| Baek, IH; Bhandary, B; Bhattarai, KR; Chae, HJ; Chai, OH; Handigund, M; Junjappa, RP; Kim, HK; Kim, HR; Lee, GH; Lee, HY; Lee, YC; Marahatta, A; Pyo, JS | 1 |
| Andreou, M; Bermudez-Brito, M; de Bree, E; Goulielmaki, E; Makrigiannakis, A; Papakonstanti, EA; Tsentelierou, E; Tzardi, M; Tzenaki, N | 1 |
| Gupta, P; Mukhopadhyay, CK; Pandey, HS; Seth, P; Singh, P | 1 |
| Ahmed, J; Aksoy, E; Alusi, G; Burns, E; Chard Dunmall, LS; Ferguson, MS; Gangeswaran, R; Hiley, C; Lemoine, NR; Marelli, G; Tysome, JR; Vanhaesebroeck, B; Wang, Y; Whitehead, MA | 1 |
| Fujita, A; Fukuyama, S; Kan-O, K; Matsumoto, K; Nakanishi, Y; Ogawa, T; Tonai, K; Yamamoto, N | 1 |
| Danzer, SC; Gross, C; MacLeod, MC; Tiwari, D; White, AR | 1 |
| Chang, P; Chen, J; Gao, L; Li, J; Liu, F; Liu, X; Lu, M; Tang, H; Tang, Y; Wang, H; Yao, L | 1 |
| Fujita, A; Fukuyama, S; Ishii, Y; Kan-O, K; Matsumoto, K; Ogawa, T; Shiota, A | 1 |
1 review(s) available for quinazolines and ic 87114
| Article | Year |
|---|---|
Small molecule inhibitors of the PI3-kinase family.
Topics: Adenine; Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Chromones; DNA-Activated Protein Kinase; DNA-Binding Proteins; Humans; Morpholines; Neoplasms; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Tumor Suppressor Proteins; Wortmannin | 2010 |
54 other study(ies) available for quinazolines and ic 87114
| Article | Year |
|---|---|
Selective role of PI3K delta in neutrophil inflammatory responses.
Topics: Adenine; Androstadienes; Animals; Anti-Inflammatory Agents; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exocytosis; Inflammation; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Morpholines; Neutrophils; Phosphatidylinositol 3-Kinases; Protein Isoforms; Quinazolines; Signal Transduction; Superoxides; Time Factors; Wortmannin | 2003 |
PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110delta the culprit?
Topics: Adenine; Animals; Aorta; Chromones; Class I Phosphatidylinositol 3-Kinases; Desoxycorticosterone; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Hypertension; Male; Mesenteric Arteries; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Subunits; Quinazolines; Rats; Rats, Sprague-Dawley; Sodium Chloride; Vascular Resistance | 2004 |
Upregulated function of phosphatidylinositol-3-kinase in genetically hypertensive rats: a moderator of arterial hypercontractility.
Topics: Adenine; Animals; Aorta; Blotting, Western; Chromones; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Immunohistochemistry; In Vitro Techniques; Male; Morpholines; Norepinephrine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents | 2005 |
Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model.
Topics: Adenine; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Chemokines; Chemotaxis, Leukocyte; Class I Phosphatidylinositol 3-Kinases; Cytokines; Eosinophilia; Female; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Animal; Mucus; Ovalbumin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinazolines | 2006 |
A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16.
Topics: Adenine; Apoptosis; Cell Proliferation; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Drug Synergism; Enzyme Activation; Etoposide; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Quinazolines | 2006 |
The p110delta isoform of PI3K differentially regulates beta1 and beta2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis.
Topics: Adenine; Androstadienes; CD18 Antigens; cdc42 GTP-Binding Protein; Cell Line; Cell Movement; Chromones; Class I Phosphatidylinositol 3-Kinases; Gene Expression Regulation; Humans; Integrin alpha4beta1; Integrin beta1; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; rac1 GTP-Binding Protein; Signal Transduction; Vascular Cell Adhesion Molecule-1; Wortmannin | 2006 |
Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma.
Topics: Adenine; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cinnamates; Class I Phosphatidylinositol 3-Kinases; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Leukocyte Count; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphoinositide-3 Kinase Inhibitors; Pneumonia; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A | 2006 |
Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism.
Topics: Adenine; Animals; Bronchial Hyperreactivity; Carbachol; Chromones; Class I Phosphatidylinositol 3-Kinases; In Vitro Techniques; Interleukin-13; Isoenzymes; Lung; Mice; Mice, Mutant Strains; Morpholines; Muscle Contraction; Muscle, Smooth; Mutant Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Tissue Extracts; Trachea | 2008 |
Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils.
Topics: Adenine; Animals; Arthritis, Experimental; Chemotaxis, Leukocyte; Class I Phosphatidylinositol 3-Kinases; Class Ib Phosphatidylinositol 3-Kinase; Edema; Enzyme Inhibitors; Hindlimb; Isoenzymes; Leukotriene B4; Mice; Mice, Inbred NOD; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Infiltration; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines | 2008 |
Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.
Topics: Adenine; Androstadienes; Apoptosis; Cells, Cultured; Chromones; Eosinophils; Humans; Hypersensitivity; Interleukin-5; Janus Kinase 2; Microscopy, Confocal; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-pim-1; Quinazolines; Tyrphostins; Wortmannin; Xanthenes | 2009 |
Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses.
Topics: Adenine; Administration, Oral; Animals; Antibodies, Bacterial; Autoantibodies; B-Lymphocyte Subsets; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Female; Gene Knock-In Techniques; Homeostasis; Isoantibodies; Mice; Mice, Inbred C57BL; Peritoneum; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Inbred Lew; Spleen | 2009 |
PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans.
Topics: Adenine; Animals; Arthritis; CD4-Positive T-Lymphocytes; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Cytokines; Humans; Hypersensitivity; Immunity; Immunologic Memory; Lymphocyte Activation; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptors, Antigen, T-Cell; Signal Transduction | 2010 |
Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Case-Control Studies; Dexamethasone; Drug Resistance; Histone Deacetylase 2; Humans; Leukocytes, Mononuclear; Mice; Oxidative Stress; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Quinazolines; RNA Interference; Smoking; Theophylline; Tobacco Smoke Pollution | 2010 |
Type I interferon (IFN-alpha/beta) rescues B-lymphocytes from apoptosis via PI3Kdelta/Akt, Rho-A, NFkappaB and Bcl-2/Bcl(XL).
Topics: Adenine; Amides; Animals; Antibodies, Blocking; Apoptosis; B-Lymphocytes; bcl-X Protein; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Gene Expression Regulation; Humans; Imidazoles; Immunologic Memory; Interferon Type I; Lymphocyte Subsets; Mice; NF-kappa B; Oncogene Protein v-akt; Peptides; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Quinazolines; Receptors, Interferon; Recombinant Proteins; rho-Associated Kinases; Signal Transduction | 2010 |
Phosphoinositide 3-kinase δ inhibitor suppresses interleukin-17 expression in a murine asthma model.
Topics: Adenine; Animals; Asthma; Bronchoalveolar Lavage Fluid; Chemotactic Factors; Eosinophils; Female; Interleukin-17; Interleukin-4; Interleukin-5; Lung; Lymphocytes; Mice; Mice, Inbred C57BL; Neutrophils; NF-kappa B; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Sulfones | 2010 |
Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.
Topics: Adenine; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Catalytic Domain; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Class I Phosphatidylinositol 3-Kinases; Dioxoles; Fibroblasts; Humans; Immunoprecipitation; Morpholines; Mutation; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Subunits; Pyrimidinones; Quinazolines; Thiazolidinediones; Transfection | 2010 |
HIF-1α inhibition ameliorates an allergic airway disease via VEGF suppression in bronchial epithelium.
Topics: 2-Methoxyestradiol; Adenine; Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Endothelial Growth Factors; Epithelial Cells; Estradiol; Female; Histocytochemistry; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred C57BL; Ovalbumin; Peptides, Cyclic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Respiratory Function Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Small Interfering; Signal Transduction; Specific Pathogen-Free Organisms; Vascular Endothelial Growth Factor A | 2010 |
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adenine; Animals; Cell Division; Cell Movement; Class I Phosphatidylinositol 3-Kinases; Cytotoxicity, Immunologic; Gene Expression Regulation; Glucose; Interferon-gamma; Interleukin-2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pore Forming Cytotoxic Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Antigen, T-Cell; Receptors, Cytokine; T-Lymphocytes, Cytotoxic; Transcription, Genetic | 2011 |
Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function.
Topics: Adenine; Blotting, Western; Extracellular Matrix; Fibroblasts; Fibronectins; Humans; Hydrazones; Interleukin-6; Isoenzymes; Mesenchymal Stem Cells; Mitochondria; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyrimidinones; Quinazolines; Respiratory System; Substrate Specificity; Sulfonamides; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2011 |
The PI3K p110δ regulates expression of CD38 on regulatory T cells.
Topics: Adenine; ADP-ribosyl Cyclase 1; Animals; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Forkhead Transcription Factors; Gene Expression Profiling; Gene Expression Regulation; Genome; Lymphocyte Subsets; Mice; Phosphatidylinositol 3-Kinases; Quinazolines; RNA, Messenger; T-Lymphocytes, Regulatory; Tretinoin | 2011 |
The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Asthma; Benzamides; Cells, Cultured; Chromones; Class I Phosphatidylinositol 3-Kinases; Contractile Proteins; Dioxoles; Female; Gene Expression Regulation; Humans; Interleukin-6; Lung; Male; Middle Aged; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Pulmonary Disease, Chronic Obstructive; Quinazolines; Tissue Donors; Transforming Growth Factor beta1 | 2012 |
Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition.
Topics: 1-Phosphatidylinositol 4-Kinase; Adenine; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Albuterol; Androstadienes; Asthma; Budesonide; Chromones; Dexamethasone; Drug Resistance; Ethanolamines; Female; Fluticasone; Formoterol Fumarate; Humans; Hydrogen Peroxide; Interleukin-8; Leukocytes, Mononuclear; Male; Middle Aged; Morpholines; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Quinazolines; Receptors, Adrenergic, beta-2; Salmeterol Xinafoate; U937 Cells; Young Adult | 2012 |
High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation.
Topics: Adenine; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Class Ia Phosphatidylinositol 3-Kinase; Female; Male; Mice; NIH 3T3 Cells; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms; Protein Isoforms; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines | 2012 |
The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.
Topics: Adenine; Animals; Asthma; Bone Marrow Cells; Cell Adhesion; Cell Movement; Chemokine CCL11; Class I Phosphatidylinositol 3-Kinases; Eosinophilia; Eosinophils; Hypersensitivity; Intercellular Adhesion Molecule-1; Macrophage-1 Antigen; Methacholine Chloride; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Respiratory System; RNA Interference; RNA, Small Interfering; Vascular Cell Adhesion Molecule-1 | 2012 |
Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts.
Topics: Adenine; Animals; Cells, Cultured; Chronic Disease; Class Ia Phosphatidylinositol 3-Kinase; Female; Flow Cytometry; Graft Rejection; H-Y Antigen; Heart Transplantation; Humans; Immune Tolerance; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Skin Transplantation; T-Lymphocytes; Transplantation, Homologous | 2012 |
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.
Topics: Adenine; Amphetamine; Analysis of Variance; Animals; Antipsychotic Agents; B-Lymphocytes; Blotting, Western; Cell Line, Transformed; Class I Phosphatidylinositol 3-Kinases; ErbB Receptors; Flow Cytometry; Genetic Association Studies; Humans; Mice; Molecular Structure; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, ErbB-4; Reverse Transcriptase Polymerase Chain Reaction; Schizophrenia; Signal Transduction | 2012 |
Finding a druggable target for schizophrenia.
Topics: Adenine; Animals; Class I Phosphatidylinositol 3-Kinases; ErbB Receptors; Humans; Neuregulin-1; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, ErbB-4; Schizophrenia; Signal Transduction | 2012 |
Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration.
Topics: Adenine; Androstadienes; Antigens, CD; Cadherins; Capillary Permeability; Cell Membrane Permeability; Cell Shape; Class Ia Phosphatidylinositol 3-Kinase; Dioxoles; Endothelial Cells; Focal Adhesion Kinase 2; Furans; Human Umbilical Vein Endothelial Cells; Humans; Leukocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Quinazolines; Signal Transduction; Thiazolidinediones; TOR Serine-Threonine Kinases; Transendothelial and Transepithelial Migration; Tumor Necrosis Factor-alpha; Wortmannin | 2012 |
Selective pharmacological inhibition of phosphoinositide 3-kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice.
Topics: Adenine; Animals; Autoimmunity; B-Lymphocytes; Diabetes Mellitus, Type 1; Disease Progression; Female; Flow Cytometry; Histocytochemistry; Insulin-Secreting Cells; Mice; Mice, Inbred NOD; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; Statistics, Nonparametric | 2013 |
Simultaneous quantitation of IC87114, roflumilast and its active metabolite roflumilast N-oxide in plasma by LC-MS/MS: application for a pharmacokinetic study.
Topics: Adenine; Aminopyridines; Animals; Benzamides; Chromatography, High Pressure Liquid; Cyclopropanes; Drug Stability; Linear Models; Male; Quinazolines; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Combined inhibition of PDE4 and PI3Kδ modulates the inflammatory component involved in the progression of chronic obstructive pulmonary disease.
Topics: Adenine; Aminopyridines; Benzamides; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Cyclopropanes; Disease Progression; Humans; Lipopolysaccharides; Macrophages; Matrix Metalloproteinase 9; Neutrophils; Nicotiana; Phosphodiesterase 4 Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Quinazolines; Smoke; U937 Cells | 2014 |
Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption.
Topics: Adenine; Androstadienes; Animals; Bone Resorption; Cell Survival; Chromones; Cytoskeleton; Indazoles; Isoenzymes; Morpholines; Osteoclasts; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; Rabbits; RANK Ligand; Rats; Sulfonamides; Wortmannin | 2013 |
The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.
Topics: Adenine; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Chlorocebus aethiops; Chromones; Class Ia Phosphatidylinositol 3-Kinase; COS Cells; Female; Mice, Inbred Strains; Mice, Nude; Morpholines; Mutation, Missense; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-kit; Quinazolines; RNA Interference; Serine; Tyrosine | 2014 |
Development and validation of a highly sensitive LC-MS/MS method for quantification of IC87114 in mice plasma, bronchoalveolar lavage and lung samples: Application to pharmacokinetic study.
Topics: Adenine; Animals; Bronchoalveolar Lavage; Chromatography, Liquid; Lung; Mice; Mice, Inbred C57BL; Quinazolines; Tandem Mass Spectrometry | 2014 |
Theoretical studies on beta and delta isoform-specific binding mechanisms of phosphoinositide 3-kinase inhibitors.
Topics: Adenine; Binding Sites; Enzyme Inhibitors; Hydrogen Bonding; Indazoles; Models, Molecular; Molecular Conformation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Conformation; Protein Isoforms; Quinazolines; Sulfonamides | 2014 |
Inhibition of PI3Kδ improves systemic lupus in mice.
Topics: Adenine; Animals; Antibodies, Antinuclear; Chemokine CCL2; Class I Phosphatidylinositol 3-Kinases; Creatinine; Interleukin-17; Interleukin-1beta; Kidney; Kidney Function Tests; Liver; Lupus Erythematosus, Systemic; Male; Mice; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proteinuria; Proto-Oncogene Proteins c-akt; Quinazolines | 2014 |
PI3K inhibitors LY294002 and IC87114 reduce inflammation in carrageenan-induced paw oedema and down-regulate inflammatory gene expression in activated macrophages.
Topics: Adenine; Animals; Carrageenan; Chemokine CCL2; Chromones; Down-Regulation; Edema; Enzyme Inhibitors; Inflammation; Interleukin-6; Macrophages; Mice; Morpholines; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Tumor Necrosis Factor-alpha | 2015 |
Inactivation of PI3Kδ induces vascular injury and promotes aneurysm development by upregulating the AP-1/MMP-12 pathway in macrophages.
Topics: Adenine; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Carotid Artery Injuries; Carotid Artery, Common; Cell Line; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Enzyme Activation; Extracellular Matrix Proteins; Gene Expression Regulation, Enzymologic; Ligation; Macrophages, Peritoneal; Male; Matrix Metalloproteinase 12; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; RNA Interference; Signal Transduction; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2015 |
Profound blockade of T cell activation requires concomitant inhibition of different class I PI3K isoforms.
Topics: Adenine; Apoptosis; Cell Differentiation; Class I Phosphatidylinositol 3-Kinases; Cytokines; Enzyme Inhibitors; Humans; Immunophenotyping; Inhibitory Concentration 50; Isoenzymes; Lymphocyte Activation; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidinones; Quinazolines; T-Lymphocytes | 2015 |
Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress.
Topics: Adenine; Animals; Aspergillosis, Allergic Bronchopulmonary; Biomarkers; Blotting, Western; Bronchoalveolar Lavage; CCAAT-Enhancer-Binding Proteins; Endoplasmic Reticulum Stress; Female; Glutathione; Glutathione Disulfide; Immunoglobulin E; Inflammation; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Phosphatidylinositol 3-Kinases; Quinazolines; RNA, Small Interfering | 2016 |
The case of an APDS patient: Defects in maturation and function and decreased in vitro anti-mycobacterial activity in the myeloid compartment.
Topics: Adenine; B-Lymphocytes; Cell Differentiation; Class I Phosphatidylinositol 3-Kinases; Dendritic Cells; Humans; Immunologic Deficiency Syndromes; In Vitro Techniques; Inflammation; Lymphopenia; Macrophages; Male; Mycobacterium bovis; Primary Immunodeficiency Diseases; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; TOR Serine-Threonine Kinases; Young Adult | 2017 |
Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family.
Topics: Adenine; Autistic Disorder; Biomarkers; Cell Line; Class I Phosphatidylinositol 3-Kinases; Diseases in Twins; Enzyme-Linked Immunosorbent Assay; Family Health; Female; Humans; Lymphocytes; Male; Molecular Targeted Therapy; Nerve Tissue Proteins; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Ribosomal Protein S6 Kinases; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production.
Topics: Adenine; Animals; Cell Differentiation; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; T-Lymphocytes | 2016 |
Pharmacological inhibition of p110δ subunit of PI3K confers protection against experimental leishmaniasis.
Topics: Adenine; Amphotericin B; Animals; CD4 Lymphocyte Count; Class I Phosphatidylinositol 3-Kinases; Cytokines; Drug Therapy, Combination; Female; Immunomodulation; Leishmania donovani; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Liver; Lymph Nodes; Mice; Mice, Inbred BALB C; Parasite Load; Phosphoinositide-3 Kinase Inhibitors; Purines; Quinazolines; Quinazolinones; Spleen; T-Lymphocytes, Regulatory | 2017 |
Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs.
Topics: Adenine; Animals; Class Ia Phosphatidylinositol 3-Kinase; Humans; Isomerism; Mice; Models, Molecular; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines | 2017 |
PI3K inhibitors IC87114 inhibits the migration and invasion of thyroid cancer cell in vitro and in vivo.
Topics: Adenine; Cell Line, Tumor; Cell Movement; Humans; Neoplasm Invasiveness; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Thyroid Neoplasms | 2018 |
PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD-RIG-I-NF-κB axis.
Topics: Adenine; Animals; Asthma; Disease Models, Animal; Endoplasmic Reticulum Stress; Lipid Peroxidation; Lipopolysaccharides; Membrane Proteins; Mice; Nerve Tissue Proteins; NF-kappa B; Ovalbumin; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Receptors, Cell Surface; Signal Transduction | 2018 |
Pharmacological inactivation of the PI3K p110δ prevents breast tumour progression by targeting cancer cells and macrophages.
Topics: Adenine; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Class Ia Phosphatidylinositol 3-Kinase; Disease Progression; Enzyme Activation; Female; Humans; Macrophages; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Staging; PTEN Phosphohydrolase; Quinazolines | 2018 |
Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation.
Topics: Adenine; Animals; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Chromones; Down-Regulation; Ferritins; Glioma; Humans; Iron; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Pyrimidinones; Quinazolines; Rats; Thiazolidinediones; Up-Regulation | 2019 |
Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus.
Topics: Adenine; Administration, Intravenous; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Combined Modality Therapy; Female; Immunotherapy; Mice; Mice, Inbred BALB C; Oncolytic Virotherapy; Oncolytic Viruses; Purines; Quinazolines; Quinazolinones; Transplantation, Homologous; Treatment Outcome; Tumor Burden; Vaccinia virus | 2020 |
Inhibition of PI3Kδ Enhances Poly I:C-Induced Antiviral Responses and Inhibits Replication of Human Metapneumovirus in Murine Lungs and Human Bronchial Epithelial Cells.
Topics: Adenine; Animals; B7-H1 Antigen; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Cytokines; Humans; Interferons; Lung; Male; Metapneumovirus; Mice; Mice, Inbred C57BL; Neutrophils; Paramyxoviridae Infections; Poly I-C; Quinazolines; Respiratory Mucosa; RNA, Small Interfering; Signal Transduction; Virus Replication | 2020 |
PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes.
Topics: Adenine; Animals; Cerebral Cortex; Class I Phosphatidylinositol 3-Kinases; Epilepsy; Female; Hippocampus; Male; Megalencephaly; Mice; Neurons; Phosphoinositide-3 Kinase Inhibitors; PTEN Phosphohydrolase; Quinazolines; Seizures; Thiazoles | 2020 |
Impaired airway epithelial barrier integrity was mediated by PI3Kδ in a mouse model of lipopolysaccharide-induced acute lung injury.
Topics: Acute Lung Injury; Adenine; Adenosine; Animals; Bronchoalveolar Lavage Fluid; Cadherins; Class I Phosphatidylinositol 3-Kinases; Claudins; Cytokines; Disease Models, Animal; Lipopolysaccharides; Lung; Male; Mice, Inbred BALB C; Quinazolines; Quinolines | 2021 |
Inhibition of PI3Kδ Differentially Regulates Poly I:C- and Human Metapneumovirus-Induced PD-L1 and PD-L2 Expression in Human Bronchial Epithelial Cells.
Topics: Adenine; Asthma; B7-H1 Antigen; Bronchi; Cells, Cultured; Epithelial Cells; Gene Expression Regulation; Humans; Interferon Regulatory Factor-3; Interferons; Metapneumovirus; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Poly I-C; Programmed Cell Death 1 Ligand 2 Protein; Protein Serine-Threonine Kinases; Quinazolines | 2021 |