Compounds > quinazolines
Page last updated: 2024-08-21

quinazolines and gx 15-070

quinazolines has been researched along with gx 15-070 in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berger, M; Lipton, A; Planas-Silva, MD; Viallet, J; Witkoski, A; Witters, LM1
Dent, P; Grant, S; Martin, AP; Mitchell, C; Nephew, KP; Rahmani, M1
Amaravadi, R1
Bareford, MD; Dent, P; Eulitt, P; Hossein, H; Martin, AP; Mitchell, C; Nephew, KP; Yacoub, A; Yang, C1
Cruickshanks, N; Dent, P; Fisher, PB; Grant, S; Hamed, HA; Tang, Y1
Bareford, MD; Cruickshanks, N; Dent, P; Fisher, PB; Grant, S; Hamed, HA; Poklepovic, A1
Booth, L; Cruickshanks, N; Dent, P; Grant, S; Hamed, H; Tang, Y1
Booth, L; Cruickshanks, N; Dent, P; Grant, S; Hamed, HA; Poklepovic, A; Sajithlal, GB; Syed, J; Tavallai, S1

Other Studies

8 other study(ies) available for quinazolines and gx 15-070

ArticleYear
Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor.
    Oncology reports, 2007, Volume: 17, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzopyrans; Breast Neoplasms; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Humans; Indoles; Lapatinib; Nitriles; Prognosis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines; Receptor, ErbB-2

2007
Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy.
    Cancer biology & therapy, 2009, Volume: 8, Issue:21

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; Cell Death; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; HCT116 Cells; Humans; Indoles; Lapatinib; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines

2009
Autophagy can contribute to cell death when combining targeted therapy.
    Cancer biology & therapy, 2009, Volume: 8, Issue:21

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Death; Colonic Neoplasms; HCT116 Cells; Humans; Indoles; Lapatinib; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines

2009
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
    Cancer biology & therapy, 2010, Nov-01, Volume: 10, Issue:9

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cyclin-Dependent Kinases; Drug Synergism; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Female; Flavonoids; Fluorescent Antibody Technique; Gene Knockout Techniques; Humans; Indoles; Lapatinib; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Piperidines; Proto-Oncogene Proteins c-bcl-2; Purines; Pyrroles; Quinazolines; Roscovitine

2010
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
    Molecular pharmacology, 2012, Volume: 81, Issue:4

    Topics: Antineoplastic Agents; Autophagy; Cell Death; Cell Line, Tumor; Genes, erbB-2; Humans; Indoles; Lapatinib; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines

2012
Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1.
    Molecular pharmacology, 2012, Volume: 81, Issue:5

    Topics: Antineoplastic Agents; Autophagy; bcl-X Protein; Cell Line, Tumor; ErbB Receptors; Humans; Indoles; Lapatinib; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Pyrroles; Quinazolines; Receptor, ErbB-3; Receptor, ErbB-4

2012
Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress.
    Molecular pharmacology, 2012, Volume: 82, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Breast Neoplasms; Cell Line, Tumor; eIF-2 Kinase; Endoplasmic Reticulum Stress; Female; HSP70 Heat-Shock Proteins; Humans; Indoles; Lapatinib; Membrane Proteins; Mice; Mice, Nude; Mitochondria; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; p38 Mitogen-Activated Protein Kinases; Pyrroles; Quinazolines; Reactive Oxygen Species

2012
Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy.
    Cancer biology & therapy, 2013, Oct-01, Volume: 14, Issue:10

    Topics: Animals; Anoikis; Antineoplastic Agents, Hormonal; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Brain Neoplasms; Breast Neoplasms; Cell Survival; Drug Resistance, Neoplasm; Epigenesis, Genetic; ErbB Receptors; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone Deacetylase Inhibitors; Humans; Indoles; Lapatinib; Mice; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Neoplastic Stem Cells; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines; Receptor, ErbB-2; RNA, Small Interfering; Valproic Acid; Xenograft Model Antitumor Assays

2013