Page last updated: 2024-08-21

quinazolines and glutamic acid

quinazolines has been researched along with glutamic acid in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (7.69)	18.7374
1990's	6 (23.08)	18.2507
2000's	12 (46.15)	29.6817
2010's	6 (23.08)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
O'Regan, MH; Perkins, LM; Phillis, JW; Simpson, RE	1
Cheng, CC; Roth, B	1
Barker, AJ; Boyle, FT; Calvert, AH; Hughes, LR; Jackman, AL; Kimbell, R; Marsham, PR; O'Connor, BM; Pegg, SJ; Wardleworth, JM	1
Rutenber, EE; Sage, CR; Stout, TJ; Stroud, RM	1
Changchien, L; Maley, F; Montfort, WR; Strop, P	1
Changchien, L; Lobo, AP; Maley, F; Montfort, WR; Nair, MG; Weichsel, A	1
Birdsall, DL; Finer-Moore, J; Huang, W; Santi, DV; Stroud, RM	1
Barabás, P; Egyed, O; Kardos, J; Kökösi, J; Kovács, I; Nagy, PI; Nyikos, L; Skuban, N; Szárics , E; Takács-Novák, K; Temesváriné-Major, E	1
Chavis, P; Westbrook, G	1
Haapalahti, JP; Johnson, MS; Jouppila, A; Keinänen, K; Lampinen, M; Mottershead, DG; Nyrönen, T; Pentikäinen, OT; Settimo, L	1
Cho, DH; Han, G; Kim, YH; Lee, IK; Yoo, ID; Yun, BS	1
Brattsand, R; Fyfe, M; Graffner-Nordberg, M; Hallberg, A; Mellgård, B	1
Araie, M; Goto, W; Hara, H; Ichikawa, M; Tanaka, E	1
Emri, Z; Héja, L; Kardos, J; Lasztóczi, B; Nyikos, L; Simon, A; Szárics, E	1
Fukuhara, T; Inoue, A; Kimura, Y; Maemondo, M; Morikawa, N; Nukiwa, T; Saijo, Y; Suzuki, T; Watanabe, H	1
Li, B; Malinow, R; Mei, L; Woo, RS	1
Chapman, J; Maggio, N; Segal, M; Shavit, E	1
Cokić, B; Stein, V	1
Blanot, D; Gobec, S; Kikelj, D; Kovac, A; Masic, LP; Rupnik, V; Tomasić, T; Zidar, N	1
AVAKIAN, S; MARTIN, GJ; MOSS, J	1
Andreou, AP; Charbit, AR; Goadsby, PJ; Summ, O	1
Gorbacheva, LR; Makarova, AM; Mikhailova, AG; Pinelis, VG; Rumsh, LD; Savinkova, IV; Strukova, SM	1
Ahlijanian, M; Bezprozvanny, I; Chen, X; Chesworth, R; Diggins, L; Glushankova, L; Hrdlicka, L; Kaznacheyeva, E; Koenig, G; Mahoney, M; Mozhayeva, GN; Shapiro, G; Shih, HP; Singh, C; Vigont, V; Wu, J; Wu, Q; Zimina, O	1
Carrillo, V; Dubisz, E; Gulzar, H; Mahajan, SS; Morgan, D; Yelskaya, Z	1
Andersen, HH; Kullander, K; Lagerström, MC; Rogoz, K	1
Aldib, I; Chikh Alard, I; De Carvalho, A; Dufrasne, F; Flemmig, J; Furtmüller, PG; Gelbcke, M; Mathieu, V; Meyer, F; Nève, J; Obinger, C; Prévost, M; Rousseau, A; Soubhye, J; Tadrent, S; Van Antwerpen, P; Zouaoui Boudjeltia, K	1

Reviews

1 review(s) available for quinazolines and glutamic acid

Article	Year
Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines. Progress in medicinal chemistry, 1982, Volume: 19 Topics: Amino Acid Sequence; Animals; Folic Acid Antagonists; Glutamates; Glutamic Acid; Malaria; Mathematics; Methotrexate; Microbial Sensitivity Tests; Models, Chemical; Pyrimethamine; Pyrimidines; Quinazolines; Stereoisomerism; Triazines	1982

Trials

1 trial(s) available for quinazolines and glutamic acid

Article	Year
Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Jul-20, Volume: 24, Issue:21 Topics: Adult; Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Arginine; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; ErbB Receptors; Feasibility Studies; Female; Gefitinib; Glutamic Acid; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Staging; Positron-Emission Tomography; Prospective Studies; Quinazolines; Treatment Outcome	2006

Article

Year

Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Jul-20, Volume: 24, Issue:21

Topics: Adult; Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Arginine; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; ErbB Receptors; Feasibility Studies; Female; Gefitinib; Glutamic Acid; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Staging; Positron-Emission Tomography; Prospective Studies; Quinazolines; Treatment Outcome

2006

Other Studies

24 other study(ies) available for quinazolines and glutamic acid

Article	Year
Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists. Journal of neurochemistry, 1992, Volume: 58, Issue:5 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Purinergic Antagonists; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Triazoles; Xanthines	1992
Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series. Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6 Topics: Animals; Antineoplastic Agents; Folic Acid; Folic Acid Antagonists; Glutamic Acid; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured	1995
An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. Biochemistry, 1996, Dec-17, Volume: 35, Issue:50 Topics: Amino Acid Sequence; Binding Sites; Crystallization; Crystallography, X-Ray; Deoxyuracil Nucleotides; Enzyme Inhibitors; Escherichia coli; Folic Acid; Glutamic Acid; Hydrogen Bonding; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Quinazolines; Recombinant Proteins; Thymidylate Synthase; Water	1996
Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu. Protein science : a publication of the Protein Society, 1997, Volume: 6, Issue:12 Topics: Antineoplastic Agents; Arginine; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Folic Acid; Folic Acid Antagonists; Glutamic Acid; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Structure; Mutation; Phosphates; Quinazolines; Thymidylate Synthase	1997
Mode of action of site-directed irreversible folate analogue inhibitors of thymidylate synthase. Biochemistry, 1998, Mar-31, Volume: 37, Issue:13 Topics: Amino Acid Sequence; Binding Sites; Cysteine; Enzyme Inhibitors; Escherichia coli; Folic Acid; Glutamic Acid; Kinetics; Molecular Sequence Data; Pyrimidines; Quinazolines; Thymidylate Synthase	1998
The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein engineering, 1998, Volume: 11, Issue:3 Topics: Amino Acid Substitution; Asparagine; Binding Sites; Catalysis; Crystallography, X-Ray; Deoxyuracil Nucleotides; Folic Acid; Glutamic Acid; Glutamine; Lacticaseibacillus casei; Mutation; Nucleotides; Protein Binding; Protein Conformation; Pyrimidines; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase	1998
Quinazolone-alkyl-carboxylic acid derivatives inhibit transmembrane Ca(2+) ion flux to (+)-(S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid. Molecular pharmacology, 2001, Volume: 59, Issue:4 Topics: Acetates; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Calcium; Calcium Channels; Cell Membrane; Cerebral Cortex; Excitatory Amino Acid Agents; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Ion Channel Gating; Ligands; Male; Models, Molecular; Molecular Structure; Piperidines; Propionates; Quinazolines; Rats; Rats, Wistar; Receptors, AMPA; Structure-Activity Relationship	2001
Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse. Nature, 2001, May-17, Volume: 411, Issue:6835 Topics: Animals; Antigens, CD; Calcium-Binding Proteins; Cell Adhesion; Cells, Cultured; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Genistein; Glutamic Acid; Hippocampus; Integrin beta3; Integrins; Intercellular Signaling Peptides and Proteins; Isoflavones; Membrane Glycoproteins; Models, Neurological; Nerve Tissue Proteins; Neurons; Oligopeptides; Peptides; Platelet Membrane Glycoproteins; Presynaptic Terminals; Protein Subunits; Quinazolines; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; Synaptotagmin I; Synaptotagmins; Tyrphostins	2001
Determinants of antagonist binding at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit, GluR-D. Role of the conserved arginine 507 and glutamate 727 residues. European journal of biochemistry, 2002, Volume: 269, Issue:24 Topics: Animals; Arginine; Binding Sites; Blotting, Western; Cell Membrane; Dose-Response Relationship, Drug; Glutamic Acid; Imidazoles; Kinetics; Ligands; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Quinazolines; Rats; Receptors, Glutamate	2002
Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata. Journal of natural products, 2002, Volume: 65, Issue:12 Topics: Agaricales; Animals; Cells, Cultured; Cerebellar Cortex; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glutamic Acid; Korea; Mice; Molecular Structure; N-Methylaspartate; Neurons; Neuroprotective Agents; Nuclear Magnetic Resonance, Biomolecular; Quinazolines; Stereoisomerism; Triterpenes	2002
Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model. Journal of medicinal chemistry, 2003, Jul-31, Volume: 46, Issue:16 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Disease Models, Animal; Female; Folic Acid Antagonists; Glutamic Acid; In Vitro Techniques; Inflammatory Bowel Diseases; Liver; Lymphocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Quinazolines; Rats; Spleen; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase	2003
Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures. Brain research, 2004, Apr-02, Volume: 1003, Issue:1-2 Topics: Animals; Brain; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Female; Glutamic Acid; Pregnancy; Protein Binding; Quinazolines; Rats; Rats, Wistar; Retina	2004
Suppression of neuronal network excitability and seizure-like events by 2-methyl-4-oxo-3H-quinazoline-3-acetyl piperidine in juvenile rat hippocampus: involvement of a metabotropic glutamate receptor. Neurochemistry international, 2006, Volume: 49, Issue:1 Topics: Age Factors; Animals; Anticonvulsants; Binding Sites; Calcium Channels; Cell Membrane; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine Triphosphate; Hippocampus; Male; Nerve Net; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Protein Subunits; Pyramidal Cells; Quinazolines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission	2006
The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity. Neuron, 2007, May-24, Volume: 54, Issue:4 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Drug Interactions; Enzyme Inhibitors; ErbB Receptors; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neuregulin-1; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Quinazolines; Rats; Receptor, ErbB-4; RNA Interference; RNA, Small Interfering; Synapses; Synaptic Transmission; Transfection; Tyrphostins	2007
Thrombin induces long-term potentiation of reactivity to afferent stimulation and facilitates epileptic seizures in rat hippocampal slices: toward understanding the functional consequences of cerebrovascular insults. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Jan-16, Volume: 28, Issue:3 Topics: Afferent Pathways; Animals; Animals, Newborn; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Epilepsy; Glutamic Acid; Hemostatics; Hippocampus; Long-Term Potentiation; Male; Peptide Fragments; Potassium; Pyrroles; Quinazolines; Rats; Rats, Wistar; Receptor, PAR-1; Thrombin	2008
Stargazin modulates AMPA receptor antagonism. Neuropharmacology, 2008, Volume: 54, Issue:7 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzodiazepines; Binding Sites; Calcium Channels; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Membrane Potentials; Microinjections; Models, Molecular; Oocytes; Patch-Clamp Techniques; Protein Structure, Tertiary; Quinazolines; Receptors, AMPA; Synaptic Transmission; Transcription, Genetic; Xenopus laevis	2008
Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase. Bioorganic & medicinal chemistry letters, 2009, Jan-01, Volume: 19, Issue:1 Topics: Anti-Bacterial Agents; Benzylidene Compounds; Enzyme Inhibitors; Escherichia coli; Glutamic Acid; Inhibitory Concentration 50; Peptide Synthases; Quinazolines	2009
Folic acid activity of N-(4-(4-quinazoline)-benzoyl)glutamic acid. The Journal of biological chemistry, 1947, Volume: 167, Issue:3 Topics: Folic Acid; Glutamic Acid; Humans; Quinazolines; Vitamin B Complex; Vitamins	1947
Modulation of nocioceptive transmission with calcitonin gene-related peptide receptor antagonists in the thalamus. Brain : a journal of neurology, 2010, Volume: 133, Issue:9 Topics: Action Potentials; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipeptides; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Iontophoresis; Male; Membrane Proteins; Midline Thalamic Nuclei; Nociceptors; Peptide Fragments; Piperazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor Activity-Modifying Proteins; Receptors, Calcitonin Gene-Related Peptide; Trigeminal Nerve	2010
Effect of enteropeptidase on survival of cultured hippocampal neurons under conditions of glutamate toxicity. Biochemistry. Biokhimiia, 2010, Volume: 75, Issue:9 Topics: Animals; Cattle; Cell Survival; Cells, Cultured; Enteropeptidase; Glutamic Acid; Hippocampus; Humans; Neurons; Pyrroles; Quinazolines; Receptor, PAR-1; Recombinant Proteins; Thrombin	2010
Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment. Chemistry & biology, 2011, Jun-24, Volume: 18, Issue:6 Topics: Animals; Apoptosis; Calcium; Cells, Cultured; Disease Models, Animal; Drosophila; Fura-2; Glutamic Acid; Huntingtin Protein; Huntington Disease; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; NF-kappa B; Nuclear Proteins; Phenyl Ethers; Quinazolines; RNA Interference; RNA, Small Interfering; TRPC Cation Channels	2011
Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. PloS one, 2013, Volume: 8, Issue:5 Topics: Amino Acids; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Gefitinib; Glioblastoma; Glutamic Acid; Humans; Quinazolines; Riluzole; Xanthenes	2013
Glutamate, substance P, and calcitonin gene-related peptide cooperate in inflammation-induced heat hyperalgesia. Molecular pharmacology, 2014, Volume: 85, Issue:2 Topics: Androstanes; Animals; Benzimidazoles; Calcitonin Gene-Related Peptide; Female; Glutamic Acid; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Nerve Growth Factor; Neurons, Afferent; Piperazines; Quinazolines; Substance P; TRPV Cation Channels; Vesicular Glutamate Transport Protein 2	2014
Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure. Journal of medicinal chemistry, 2017, 08-10, Volume: 60, Issue:15 Topics: Benzimidazoles; Cell Line; Databases, Chemical; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutamic Acid; Glutamine; Guanidines; Humans; Hydrogen Peroxide; Kinetics; Lactoperoxidase; Lipoproteins, LDL; Models, Chemical; Molecular Docking Simulation; Neutrophils; Oxidation-Reduction; Peroxidase; Quinazolines; Stereoisomerism	2017