quinazolines has been researched along with fluorodeoxyuridylate in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 10 (58.82) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keyomarsi, K; Moran, RG | 1 |
| Appelt, K; Matthews, DA; Oatley, SJ; Xuong, NH | 1 |
| Appelt, K; Matthews, DA; Oatley, SJ | 1 |
| Maley, F; Maley, GF | 1 |
| Garvey, EP; Santi, DV | 1 |
| Peters, GJ; Pinedo, HM; Telleman, F; van der Wilt, CL; van Triest, B | 1 |
| Connick, TJ; Dunlap, RB; Ellis, PD; Reilly, RT | 2 |
| Hekmat-Nejad, M; Rathod, PK | 1 |
| Dabrowska, M; Michalski, R; Pawelczak, K; Rode, W; Wranicz, M; Zieliñski, Z | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Telleman, F; van der Wilt, CL; van Triest, B | 1 |
| Banerjee, D; Bertino, JR; Capiaux, GM; Ercikan-Abali, EA; Liu-Chen, X; Tong, Y; Zhao, SC | 1 |
| Biermann, D; Finer-Moore, J; Michelitsch, MD; Nissen, R; Sage, CR; Stout, TJ; Stroud, RM | 1 |
| Berger, FG; Fantz, C; Forsthoefel, A; Jennings, W; Kitchens, M; Lebioda, L; Minor, W; Phan, J; Shaw, D; Spencer, HT | 1 |
| Anderson, KS; Atreya, CE; Chang, SY; Johnson, EF; Liang, PH; Williamson, J | 1 |
| Antony, S; Gmeiner, WH; Kohlhagen, G; Liao, ZY; Pommier, Y; Sordet, O; Zhang, HL | 1 |
| Bijnsdorp, IV; Comijn, EM; Gmeiner, WH; Padron, JM; Peters, GJ | 1 |
17 other study(ies) available for quinazolines and fluorodeoxyuridylate
| Article | Year |
|---|---|
Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate.
Topics: Animals; Binding Sites; Cytidine Monophosphate; Floxuridine; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Mice; Models, Structural; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1990 |
Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2'-deoxyuridylate and 10-propargyl-5,8-dideazafolate.
Topics: Amino Acid Sequence; Binding Sites; Deoxyuracil Nucleotides; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Ligands; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Conformation; Quinazolines; Thymidylate Synthase | 1990 |
Crystal structure of Escherichia coli thymidylate synthase with FdUMP and 10-propargyl-5,8-dideazafolate.
Topics: Deoxyuracil Nucleotides; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Kinetics; Models, Molecular; Protein Binding; Protein Conformation; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase; X-Ray Diffraction | 1989 |
Properties of a defined mutant of Escherichia coli thymidylate synthase.
Topics: Amino Acids; Cysteine; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Mutation; Peptide Mapping; Quinazolines; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase; Tyrosine | 1988 |
A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction.
Topics: Animals; Binding, Competitive; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Kinetics; Leishmania tropica; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase | 1987 |
Cross-resistance to thymidylate synthase inhibitors in P-glycoprotein and non-P-glycoprotein cell lines.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Cycle; Cell Line; Clone Cells; Doxorubicin; Drug Resistance, Multiple; Fluorodeoxyuridylate; Fluorouracil; Humans; Lung Neoplasms; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1994 |
Fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase utilizing a fluorine-labeled folate analogue.
Topics: Fluorine; Fluorodeoxyuridylate; Folic Acid; Lacticaseibacillus casei; Macromolecular Substances; Magnetic Resonance Spectroscopy; Protein Binding; Protein Conformation; Protein Denaturation; Quinazolines; Thymidylate Synthase | 1993 |
Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694.
Topics: Animals; Antimalarials; Enzyme Inhibitors; Fluorodeoxyuridylate; Kinetics; Orotic Acid; Plasmodium falciparum; Quinazolines; Thiophenes; Thymidylate Synthase | 1996 |
Trichinella spiralis thymidylate synthase: developmental pattern, isolation, molecular properties, and inhibition by substrate and cofactor analogues.
Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Fluorodeoxyuridylate; Folic Acid; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Larva; Liver; Liver Regeneration; Muscles; Quinazolines; Rats; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Trichinella spiralis | 1996 |
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Division; Drug Resistance, Multiple; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Humans; Indoles; Isoindoles; Methotrexate; Peptide Synthases; Polymerase Chain Reaction; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells.
Topics: Cloning, Molecular; Drug Resistance; Enzyme Inhibitors; Escherichia coli; Ethyl Methanesulfonate; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Mutagenesis; Mutagenesis, Site-Directed; Polymorphism, Single-Stranded Conformational; Quinazolines; Recombinant Proteins; Sarcoma; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Topics: Asparagine; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Hydrogen Bonding; Imidazoles; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Substrate Specificity; Tetrahydrofolates; Thymidylate Synthase | 1998 |
Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Topics: Amino Acid Substitution; Crystallography, X-Ray; Deoxyuracil Nucleotides; Drug Resistance; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Fluorodeoxyuridylate; Folic Acid Antagonists; Humans; Kinetics; Mutation; Proline; Protein Conformation; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Transfection | 2000 |
Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.
Topics: Animals; Binding Sites; Catalysis; Crystallization; Enzyme Stability; Fluorodeoxyuridylate; Folic Acid; Hydrocarbons; Kinetics; Leishmania major; Methane; Models, Molecular; Molecular Structure; Multienzyme Complexes; Mutagenesis, Site-Directed; NADP; Quinazolines; Spectrophotometry; Static Electricity; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase | 2003 |
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Death; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; DNA, Single-Stranded; Drug Screening Assays, Antitumor; Fluorodeoxyuridylate; Fluorouracil; Leukemia P388; Mice; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Topoisomerase I Inhibitors | 2005 |
Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2007 |