quinazolines has been researched along with fluorine in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, L; Joshi, KC; Mehta, DS; Sharma, RC; Singh, VK | 1 |
| Bishop, JA; Calvert, AH; Jackman, AL; Marsham, PR; O'Connor, BM; Thornton, TJ | 1 |
| Narayanan, A; Pradet, A | 1 |
| Fetzer, OS; Freisheim, JH; Hynes, JB; Shane, B | 1 |
| Connick, TJ; Dunlap, RB; Ellis, PD; Reilly, RT | 1 |
| Ballard, P; Bradbury, RH; Harris, CS; Hennequin, LF; Hickinson, M; Kendrew, J; Kettle, JG; Klinowska, T; Ogilvie, DJ; Pearson, SE; Williams, EJ; Wilson, I | 1 |
| Donovan, C; Emerson, D; Lall, M; Lee, DY; Melnick, MM; Miller, JR; Ohren, J; Sarver, RW; Thanabal, V | 1 |
| Balakumar, C; Kishore, DP; Lamba, P; Narayana, BL; Narsaiah, B; Rajwinder, K; Rao, AR; Rao, KV; Shireesha, B | 1 |
| Barbar Asskar, G; Briel, D; Brust, P; Egerland, U; Funke, U; Höfgen, N; Kubicova, L; Nieber, K; Scheunemann, M; Schwan, G; Sträter, N; Zahn, M | 1 |
| Gadotti, VM; Huang, J; Jeong, HR; Jung, DW; Kim, HJ; Kim, JH; Kim, SY; Lee, JY; Lee, KT; Yoon, HB; Zamponi, GW; Zhang, FX | 1 |
| Akher, FB; Farrokhzadeh, A; Kuttel, MM; Ravenscroft, N | 1 |
11 other study(ies) available for quinazolines and fluorine
| Article | Year |
|---|---|
Fluorinated quinazolones III: synthesis and CNS depressant activity of fluorinated quinazolone derivatives.
Topics: Animals; Avoidance Learning; Central Nervous System; Depression, Chemical; Female; Fluorine; Male; Mice; Pentobarbital; Pentylenetetrazole; Quinazolines; Rats; Sleep; Time Factors | 1975 |
Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.
Topics: Animals; Antineoplastic Agents; Benzene; Cell Division; Fluorine; Folic Acid Antagonists; Leukemia L1210; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1992 |
Fluorinated quinazolones: effect of some fluorinated 2-alkyl-3-aryl-4(3H)-quinazolones & thioquinazolones on pyruvic acid oxidation in rat brain homogenates.
Topics: Animals; Brain; Depression, Chemical; Fluorine; In Vitro Techniques; Oxidation-Reduction; Pyruvates; Quinazolines; Rats | 1974 |
Synthesis and preliminary biological evaluation of analogues of 5,8-dideazaisofolic acid and its 2-desamino-2-methyl derivative containing fluorine at position five.
Topics: Animals; Cell Survival; Fluorine; Folic Acid Antagonists; Leukemia L1210; Liver; Methotrexate; Mice; Peptide Synthases; Quinazolines; Structure-Activity Relationship; Swine; Tumor Cells, Cultured | 1993 |
Fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase utilizing a fluorine-labeled folate analogue.
Topics: Fluorine; Fluorodeoxyuridylate; Folic Acid; Lacticaseibacillus casei; Macromolecular Substances; Magnetic Resonance Spectroscopy; Protein Binding; Protein Conformation; Protein Denaturation; Quinazolines; Thymidylate Synthase | 1993 |
Inhibitors of epidermal growth factor receptor tyrosine kinase: optimisation of potency and in vivo pharmacokinetics.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; ErbB Receptors; Fluorine; Gefitinib; Humans; Inhibitory Concentration 50; Mice; Molecular Structure; Neoplasms; Protein Kinase Inhibitors; Quinazolines; Rats; Structure-Activity Relationship; Thiazoles; Xenograft Model Antitumor Assays | 2006 |
The use of biochemical and biophysical tools for triage of high-throughput screening hits - A case study with Escherichia coli phosphopantetheine adenylyltransferase.
Topics: Anti-Bacterial Agents; Binding, Competitive; Biophysical Phenomena; Calorimetry; Catalytic Domain; Escherichia coli; Fluorine; High-Throughput Screening Assays; Kinetics; Magnetic Resonance Spectroscopy; Nucleotidyltransferases; Quinazolines; Structure-Activity Relationship | 2010 |
Synthesis, anti-inflammatory evaluation and docking studies of some new fluorinated fused quinazolines.
Topics: Animals; Anti-Inflammatory Agents; Drug Evaluation, Preclinical; Female; Fluorine; Magnetic Resonance Spectroscopy; Models, Molecular; Quinazolines; Rats; Rats, Wistar | 2010 |
Fluorine-containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10 A: synthesis and in vitro evaluation of inhibitory potency, selectivity, and metabolism.
Topics: Animals; Binding Sites; Drug Design; Fluorine; Humans; Ligands; Liver; Male; Molecular Docking Simulation; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Quantitative Structure-Activity Relationship; Quinazolines; Rats | 2014 |
Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects.
Topics: A549 Cells; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Survival; Drug Stability; Fluorine; HEK293 Cells; Humans; Inhibitory Concentration 50; Microsomes, Liver; Patch-Clamp Techniques; Quinazolines; Quinidine; Rats | 2017 |
Mechanistic Study of Potent Fluorinated EGFR Kinase Inhibitors with a Quinazoline Scaffold against L858R/T790M/C797S Resistance Mutation: Unveiling the Fluorine Substituent Cooperativity Effect on the Inhibitory Activity.
Topics: Drug Resistance, Neoplasm; ErbB Receptors; Fluorine; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors; Quinazolines | 2020 |