quinazolines has been researched along with febrifugine in 50 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (8.00) | 18.7374 |
1990's | 3 (6.00) | 18.2507 |
2000's | 22 (44.00) | 29.6817 |
2010's | 17 (34.00) | 24.3611 |
2020's | 4 (8.00) | 2.80 |
Authors | Studies |
---|---|
Cheng, CC | 1 |
Cheng, CC; Chien, PL | 1 |
Fushiya, S; Murata, K; Oshima, Y; Takano, F | 2 |
Chiba, T; Kim, HS; Miura, M; Oshima, Y; Takaya, Y; Takeshita, M; Tanitsu, M; Tasaka, H; Uwai, K; Wataya, Y | 1 |
Ogasawara, K; Taniguchi, T | 1 |
Esumi, T; Hatakeyama, S; Iwabuchi, Y; Ooi, H; Urushibara, A | 1 |
Abe, H; Azuma, K; Harayama, T; Kim, HS; Koike, M; Nishioka, H; Takeuchi, Y; Wataya, Y | 1 |
Hagio, H; Hirabayashi, R; Kobayashi, S; Sugiura, M | 1 |
Hatakeyama, S; Hirai, S; Iwabuchi, Y; Kikuchi, H; Kim, HS; Ooi, H; Oshima, Y; Takaya, Y; Tasaka, H; Wataya, Y | 1 |
Abe, H; Azuma, K; Harayama, T; Sasaki, K; Takeuchi, Y | 1 |
Ishih, A; Miyase, T; Ohori, K; Terada, M | 1 |
Begum, K; Hirai, S; Kikuchi, H; Kim, HS; Miyazawa, Y; Oshima, Y; Tasaka, H; Wataya, Y; Yamamoto, K | 1 |
SYRKINA-KRUGLIAK, SA; VERMEL', EM | 1 |
Ishih, A; Miyase, T; Suzuki, T; Terada, M; Watanabe, M | 1 |
Ishih, A; Kobayashi, F; Miyase, T; Nagata, T; Terada, M | 1 |
COATNEY, GR; COOPER, WC; CULWELL, WB; IMBODEN, CA; WHITE, WC | 1 |
Fang, D; Gettayacamin, M; Hansukjariya, P; Jiang, S; Lim, A; Okunji, CO; Tungtaeng, A; Wannaying, S; Zeng, Q; Zhu, S | 1 |
Abe, H; Azuma, K; Harayama, T; Oshige, M; Takeuchi, Y | 1 |
Scheindlin, S | 1 |
Meng, L; Wei, L; Zhang, Q; Zhu, S | 1 |
Hariguchi, N; Hirai, S; Horoiwa, S; Kasahara, R; Kikuchi, H; Matsumoto, M; Oshima, Y; Yamamoto, K | 1 |
Prabhakar, S; Ramanjaneyulu, GS; Rao, BV; Sudhakar, N | 1 |
Fan, GJ; Wee, AG | 1 |
Ishih, A; Kobayashi, F; Miyase, T; Muregi, FW; Nagata, T; Ohori, K | 1 |
Samant, BS; Sukhthankar, MG | 1 |
Gudise, C; Smith, E; Wei, L; Zeng, Y; Zhang, Q; Zhu, S | 1 |
Blaauw, RH; Botman, PN; Rutjes, FP; Schoemaker, HE; van Delft, FL; van den Berg, RJ; Wijdeven, MA; Wijtmans, R | 1 |
Chen, W; Liebeskind, LS | 1 |
Evans, P; McLaughlin, NP | 1 |
Chandrashekar, G; Chatterji, D; Meng, L; Robinson, K; Zhu, S | 1 |
Cortese, JF; Dignam, JD; Edenius, M; Hendrick, M; Keller, TL; Kim, YJ; Lee, HK; Mazitschek, R; Rao, A; Sundrud, MS; Whitman, M; Wirth, DF; Yeo, CY; Yum, J; Zocco, D | 1 |
Schimmel, P; Sun, L; Yang, XL; Zhou, H | 1 |
Hariguchi, N; Horoiwa, S; Kasahara, R; Kikuchi, H; Matsumoto, M; Oshima, Y | 1 |
Evans, P; McLaughlin, NP; Pines, M | 1 |
Funayama, S | 1 |
Jain, V; Kikuchi, H; Oshima, Y; Sharma, A; Yogavel, M | 1 |
Chau, VM; Le, CV; Mai, HD; Nguyen, TL; Pham, VC; Phi, TD; Thanh, GV; Tran, VH; Truong, BN; Vu, VL; Vu, VN | 1 |
Bopp, SE; Clardy, J; Clish, CB; Cortese, JF; Derbyshire, ER; Estiu, G; Galinsky, K; Herman, JD; Keller, TL; Lindquist, S; Lukens, AK; Mazitschek, R; Mota, MM; Patel, V; Pepper, LR; Ribacke, U; Santos, SA; Schimmel, P; Sullivan, WJ; Whitman, M; Wiest, O; Wirth, DF; Zhou, H; Zuzarte-Luis, V | 1 |
Chen, P; Liu, G; Wu, L | 1 |
Malik, R; Narula, A; Naskar, M; Pandey, RK; Prajapati, VK; Shah, P; Srivastava, S; Verma, P | 1 |
Kumbhar, BV; Kunwar, A; Malik, R; Pandey, RK; Prajapati, VK; Srivastava, S; Sundar, S | 1 |
Feng, WH; Li, C; Liu, XQ; Liu, ZH; Wang, ZM; Yang, LX; Zhang, JY | 1 |
Feng, WH; Li, C; Liu, XQ; Wang, ZM; Yang, LX; Zhang, JY | 1 |
Fan, XR; Feng, WH; Guo, ZT; Li, C; Liu, XQ; Wang, ZM; Yang, LX; Yu, XW; Zhang, JY | 1 |
Evans, P; McLaughlin, NP; Smullen, S | 1 |
Gao, Y; Hou, H; Li, C; Ma, L; Pan, H; Su, P; Sun, J; Wang, F; Ye, Z; Zang, C; Zhang, G | 1 |
Tang, C; Wu, J; Xu, J | 1 |
Ma, JL; Sheng, LQ | 1 |
Li, PP; Wang, JP; Zhang, L | 1 |
2 review(s) available for quinazolines and febrifugine
Article | Year |
---|---|
The chemistry and biology of febrifugine and halofuginone.
Topics: Antimalarials; Humans; Molecular Structure; Parasitic Sensitivity Tests; Piperidines; Plasmodium; Quinazolines; Quinazolinones; Structure-Activity Relationship | 2014 |
Chemical synthesis of febrifugine and analogues.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Cyclization; Cycloaddition Reaction; Humans; Piperidines; Plasmodium falciparum; Quinazolines; Quinazolinones; Stereoisomerism | 2018 |
48 other study(ies) available for quinazolines and febrifugine
Article | Year |
---|---|
Structural similarity between febrifugine and chloroquine.
Topics: Antimalarials; Chloroquine; Models, Structural; Piperidines; Quinazolines; Structure-Activity Relationship | 1976 |
Structural modification of febrifugine. Some methylenedioxy analogs.
Topics: Animals; Antimalarials; Female; Male; Mice; Piperidines; Plasmodium; Quinazolines | 1970 |
Enhancement of NO production in activated macrophages in vivo by an antimalarial crude drug, Dichroa febrifuga.
Topics: Animals; Antimalarials; China; In Vitro Techniques; Macrophages; Male; Mass Spectrometry; Mice; Mice, Inbred ICR; Nitric Oxide; Piperidines; Plant Extracts; Plant Roots; Plants, Medicinal; Quinazolines; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1998 |
New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite.
Topics: Animals; Antimalarials; Drugs, Chinese Herbal; Malaria; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Conformation; Piperidines; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Quinazolinones; Quinolizines | 1999 |
Potentiation by febrifugine of host defense in mice against Plasmodium berghei NK65.
Topics: Animals; Antimalarials; Drug Interactions; Enzyme Inhibitors; Malaria; Male; Mice; Mice, Inbred ICR; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Parasitemia; Piperidines; Plasmodium berghei; Quinazolines | 1999 |
A diastereocontrolled synthesis of (+)-febrifugine: a potent antimalarial piperidine alkaloid.
Topics: Alkaloids; Antimalarials; Piperidines; Plants, Medicinal; Quinazolines; Stereoisomerism | 2000 |
A concise enantioselective synthesis of antimalarial febrifugine alkaloids.
Topics: Alkaloids; Antimalarials; Indicators and Reagents; Molecular Conformation; Molecular Structure; Piperidines; Quinazolines; Stereoisomerism | 2001 |
Synthesis and antimalarial activity of febrifugine derivatives.
Topics: Antimalarials; Piperidines; Quinazolines | 2001 |
Lewis acid-catalyzed ring-opening reactions of semicyclic N,O-acetals possessing an exocyclic nitrogen atom: mechanistic aspect and application to piperidine alkaloid synthesis.
Topics: Acetals; Acids; Alkaloids; Ethers, Cyclic; Nitrogen; Piperidines; Quinazolines; Stereoisomerism | 2001 |
Potent antimalarial febrifugine analogues against the plasmodium malaria parasite.
Topics: Animals; Antimalarials; Cell Line; Malaria; Mice; Piperidines; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship | 2002 |
Re-revision of the stereo structure of piperidine lactone, an intermediate in the synthesis of febrifugine.
Topics: Antimalarials; Indicators and Reagents; Lactones; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Piperidines; Quinazolines | 2002 |
Different responses of three rodent Plasmodia species, Plasmodium yoelii 17XL, P. berghei NK65 and P. chabaudi AS on treatment with febrifugine and isofebrifugine mixture from Hydrangea macrophylla var. Otaksa leaf in ICR mice.
Topics: Administration, Oral; Animals; Antimalarials; Hydrangea; Malaria; Male; Mice; Mice, Inbred ICR; Parasitic Sensitivity Tests; Phytotherapy; Piperidines; Plant Extracts; Plant Leaves; Plasmodium; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Quinazolines | 2003 |
Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite.
Topics: Administration, Oral; Animals; Antimalarials; Antineoplastic Agents; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Liver; Mammary Neoplasms, Experimental; Mice; Nuclear Magnetic Resonance, Biomolecular; Piperidines; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
[The antineoplastic activity of the alkaloid febrifugine in experiments on animals].
Topics: Alkaloids; Animals; Antineoplastic Agents; Piperidines; Quinazolines | 1960 |
Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice.
Topics: Animals; Antimalarials; Chloroquine; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Malaria; Male; Mice; Mice, Inbred ICR; Parasitic Sensitivity Tests; Phytotherapy; Piperidines; Plasmodium berghei; Quinazolines | 2003 |
Cytokine and antibody production during the course of resolution in Plasmodium yoelii 17XL-infected BALB/c mice treated with febrifugine and isofebrifugine mixture from leaves of Hydrangea macrophylla var. Otaksa.
Topics: Animals; Antibodies, Protozoan; Cytokines; Female; Hydrangea; Malaria; Mice; Mice, Inbred BALB C; Phytotherapy; Piperidines; Plant Leaves; Plasmodium yoelii; Quinazolines | 2004 |
Studies in human malaria. XXV. Trial of febrifugine, an alkaloid obtained from Dichroa febrifuga lour., against the Chesson strain of Plasmodium vivax.
Topics: Alkaloids; Malaria; Piperidines; Plants; Plasmodium vivax; Quinazolines | 1950 |
Antimalarial activities and therapeutic properties of febrifugine analogs.
Topics: Animals; Antimalarials; Cell Line; Macrophages; Mice; Mice, Inbred ICR; Piperidines; Quinazolines | 2005 |
Concise synthesis of dl-febrifugine.
Topics: Antimalarials; Molecular Structure; Piperidines; Quinazolines | 2005 |
Antimalarials: shortages and searches.
Topics: Antimalarials; Artemisia; Artemisinins; History, 20th Century; History, 21st Century; Humans; Hydrangea; Methaqualone; Piperidines; Plant Extracts; Quinazolines; Quinine; World War II | 2005 |
Synthesis and evaluation of febrifugine analogues as potential antimalarial agents.
Topics: Animals; Antimalarials; Drug Evaluation, Preclinical; Hepatocytes; Magnetic Resonance Spectroscopy; Piperidines; Plasmodium falciparum; Quinazolines; Rats | 2006 |
Exploration of a new type of antimalarial compounds based on febrifugine.
Topics: Animals; Antimalarials; Cell Line; Malaria; Mice; Parasitic Sensitivity Tests; Piperidines; Plasmodium berghei; Plasmodium falciparum; Pyrimidinones; Quinazolines; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Toxicity Tests, Acute | 2006 |
Differentiation of the diastereomeric synthetic precursors of isofebrifugine and febrifugine by electrospray ionization tandem mass spectrometry.
Topics: Antimalarials; Hydrangea; Isomerism; Molecular Structure; Piperidines; Plants, Medicinal; Quinazolines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Asymmetric synthesis of (+)-isofebrifugine and (-)-sedacryptine from a common chiral nonracemic building block.
Topics: Alkaloids; Piperidines; Piperidones; Quinazolines; Stereoisomerism | 2008 |
Possible involvement of IFN-gamma in early mortality of Plasmodium berghei NK65-infected BALB/c mice after febrifugine treatment.
Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Interferon-gamma; Interleukin-4; Malaria; Male; Mice; Mice, Inbred BALB C; Parasitemia; Piperidines; Plasmodium berghei; Quinazolines | 2008 |
Synthesis and comparison of antimalarial activity of febrifugine derivatives including halofuginone.
Topics: Animals; Antimalarials; Benzoates; Cell Line; Piperidines; Plasmodium falciparum; Quinazolines; Quinazolinones | 2009 |
Synthesis and biological evaluation of febrifugine analogues as potential antimalarial agents.
Topics: Animals; Antimalarials; Drug Evaluation, Preclinical; Hydrangeaceae; Malaria; Mice; Molecular Structure; Parasitic Sensitivity Tests; Piperidines; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship | 2009 |
Complementary chemoenzymatic routes to both enantiomers of febrifugine.
Topics: Catalysis; Piperidines; Quinazolines; Stereoisomerism; Substrate Specificity | 2009 |
A new reaction motif: "homo-S(N)2'-like" direct nucleophilic addition to neutral eta(3)-allylmolybdenum complexes. total synthesis of the antimalarial (+)-isofebrifugine.
Topics: Antimalarials; Molybdenum; Organometallic Compounds; Piperidines; Pyridines; Quinazolines; Stereoisomerism; Substrate Specificity | 2009 |
Dihydroxylation of vinyl sulfones: stereoselective synthesis of (+)- and (-)-febrifugine and halofuginone.
Topics: Catalysis; Hydroxylation; Molecular Structure; Piperidines; Quinazolines; Quinazolinones; Stereoisomerism; Sulfones | 2010 |
Febrifugine analogue compounds: synthesis and antimalarial evaluation.
Topics: Animals; Antimalarials; Aotus trivirgatus; Drug Evaluation, Preclinical; Malaria; Piperidines; Plasmodium falciparum; Quinazolines | 2012 |
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Topics: Amino Acyl-tRNA Synthetases; Animals; Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Mice; Mice, Inbred C57BL; Piperidines; Quinazolines; Quinazolinones; Structure-Activity Relationship; Th17 Cells | 2012 |
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Antimalarials; Binding Sites; Crystallography, X-Ray; Herbal Medicine; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ligands; Medicine, Chinese Traditional; Models, Molecular; Piperidines; Proline; Quinazolines; Quinazolinones; RNA, Transfer | 2013 |
Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial.
Topics: Animals; Antimalarials; Magnetic Resonance Spectroscopy; Piperidines; Plasmodium falciparum; Quinazolines; Spectrometry, Mass, Fast Atom Bombardment | 2014 |
[Hydrangea Hydrangea macrophylla].
Topics: Adult; Female; Foodborne Diseases; Humans; Hydrangea; Male; Middle Aged; Piperidines; Quinazolines; Stereoisomerism | 2014 |
Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.
Topics: Amino Acyl-tRNA Synthetases; Antimalarials; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Malaria, Falciparum; Piperidines; Plasmodium falciparum; Protozoan Proteins; Quinazolines | 2014 |
Synthesis and biological evaluation of febrifugine analogues.
Topics: Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Humans; Piperidines; Plasmodium falciparum; Quinazolines | 2014 |
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Topics: Amino Acyl-tRNA Synthetases; Animals; Antimalarials; Computer-Aided Design; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Resistance; Enzyme Inhibitors; Erythrocytes; Liver; Malaria, Falciparum; Mice; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Piperidines; Plasmodium falciparum; Protozoan Proteins; Quinazolines; Quinazolinones; Structure-Activity Relationship; Time Factors | 2015 |
Pd(II)-Catalyzed Aminofluorination of Alkenes in Total Synthesis 6-(R)-Fluoroswainsonine and 5-(R)-Fluorofebrifugine.
Topics: Alkaloids; Alkenes; Catalysis; Molecular Structure; Palladium; Piperidines; Pyridines; Quinazolines; Stereoisomerism; Swainsonine | 2016 |
Exploring dual inhibitory role of febrifugine analogues against Plasmodium utilizing structure-based virtual screening and molecular dynamic simulation.
Topics: Amino Acyl-tRNA Synthetases; Antimalarials; Aspartic Acid Endopeptidases; Drug Design; Drug Evaluation, Preclinical; Humans; Molecular Conformation; Molecular Dynamics Simulation; Molecular Structure; Piperidines; Plasmodium falciparum; Protein Binding; Protozoan Proteins; Quinazolines; Structure-Activity Relationship | 2017 |
Febrifugine analogues as Leishmania donovani trypanothione reductase inhibitors: binding energy analysis assisted by molecular docking, ADMET and molecular dynamics simulation.
Topics: Antiprotozoal Agents; Binding Sites; Drug Design; Enzyme Inhibitors; Leishmania donovani; Ligands; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; NADH, NADPH Oxidoreductases; Piperidines; Protein Binding; Protein Multimerization; Quinazolines; ROC Curve; Structure-Activity Relationship | 2017 |
[Simultaneous determination of febrifugine and isofebrifugine in Dichroa febrifuga root by HPLC method].
Topics: Chromatography, High Pressure Liquid; Hydrangea; Piperidines; Plant Roots; Quinazolines | 2017 |
[Investigation on stability and degradation kinetics of febrifugine].
Topics: Drug Stability; Hydrogen-Ion Concentration; Kinetics; Piperidines; Quinazolines; Temperature | 2017 |
[Quantitative determination of febrifugine by proton nuclear magnetic resonance spectroscopy with internal standard method].
Topics: Magnetic Resonance Spectroscopy; Piperidines; Protons; Quinazolines | 2018 |
Preparation and
Topics: Animals; Liposomes; Mice; Particle Size; Piperidines; Polyethylene Glycols; Quinazolines | 2020 |
Effect of isofebrifugine on the proliferation and invasion of human gastric cancer cells via MMP.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CXCL12; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Piperidines; Quinazolines; RNA, Messenger; Stomach Neoplasms | 2020 |
Preparative separation of two isomeric antimalaria alkaloids febrifugine and isofebrifugine from Dichroa febrifuga roots by countercurrent chromatography.
Topics: Alkaloids; Countercurrent Distribution; Hydrangea; Piperidines; Plant Extracts; Plant Roots; Quinazolines | 2021 |
Research Note: Study on the residue depletion of febrifugine and isofebrifugine in broiler chicken.
Topics: Animals; Chickens; Drug Residues; Liver; Meat; Piperidines; Quinazolines | 2021 |