quinazolines has been researched along with evodiamine in 303 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (0.99) | 18.7374 |
| 1990's | 12 (3.96) | 18.2507 |
| 2000's | 60 (19.80) | 29.6817 |
| 2010's | 169 (55.78) | 24.3611 |
| 2020's | 59 (19.47) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CF; Chiou, WF; Chou, CJ; Shum, AY | 1 |
| Kano, Y; Komatsu, K; Qine, Z | 1 |
| Fujimura, H; Kitani, T; Naitoh, Y; Yamada, T; Yamahara, J | 1 |
| Kajiwara, A; Ohizumi, Y; Shoji, N; Takemoto, T; Umeyama, A | 1 |
| Chen, CF; Chou, CJ; Jeng, KF; Lin, LC; Lin, YH; Tsai, TH | 1 |
| Chen, CF; Lee, TF; Tsai, TH; Wang, LC | 1 |
| Kano, Y; Komatsu, K; Wakame, K | 1 |
| Chen, CF; Chiou, WF; Liao, JF | 1 |
| Momma, N; Ohsawa, K; Ueda, J; Yamauchi, Y; Yoshie, F | 1 |
| Iinuma, M; Kubo, M; Matsuda, H; Tanaka, T; Wu, JX | 1 |
| Chen, CF; Chiou, WF; Liao, JF; Shum, AY; Sung, YJ | 1 |
| Hirose, M; Houchi, H; Ishimura, Y; Kitagawa, T; Minakuchi, K; Tamaki, T; Tsuchiya, K; Yoshizumi, M | 1 |
| Chen, CF; Chen, JJ; Chiao, YC; Lin, H; Tsai, SC; Wang, GJ; Wang, PS; Wang, SW | 1 |
| Hoshikuma, K; Kamiya, T; Kobayashi, Y; Nakano, Y; Yokoo, Y | 2 |
| Guo, J; Lu, Q; Sun, X; Wei, X; Yao, Z; Zhang, D; Zhang, X; Zhang, Z | 1 |
| Matsubara, T; Ogasawara, M; Suzuki, H | 1 |
| Chen, CF; Hung, PH; Lin, LC; Wang, GJ; Wang, PS | 1 |
| Hoshikuma, K; Kamiya, T; Kizaki, M; Kobayashi, Y; Nakano, Y; Yokoo, Y | 1 |
| Chen, CF; Chen, TL; Guengerich, FP; Jan, WC; Lin, LC; Ueng, YF | 1 |
| Chen, CF; Chiou, WF | 1 |
| Chen, CF; Chen, KT; Ko, HC; Ueng, YF; Wang, JJ | 1 |
| Matsunaga, T; Ogasawara, M; Saiki, I; Suzuki, H; Takahashi, S | 1 |
| Chang, FY; Hung, CR; Lin, LC; Pau, KY; Wang, PS; Wu, CL | 1 |
| Fei, XF; Ikejima, T; Wang, BX | 1 |
| Deng, HW; Du, YH; Hu, CP; Li, YJ; Rang, WQ; Tan, GS; Ye, F | 1 |
| Fei, XF; Ikejima, T; Li, TJ; Minami, M; Tashiro, S; Wang, BX; Xing, DJ | 1 |
| Wang, YL; Wei, LX; Xu, YC; Zhou, YX | 1 |
| Kobayashi, Y | 2 |
| Ikejima, T; Onodera, S; Tashiro, S; Wu, LJ; Zhang, Y | 3 |
| Dai, Y; Dou, C; Liu, B | 1 |
| Ikejima, T; Onodera, S; Tashiro, S; Wu, LJ; Zhang, QH; Zhang, Y | 1 |
| Ogasawara, M; Suzuki, H | 1 |
| Guh, JH; Huang, YC; Teng, CM | 1 |
| Huang, WJ; Kan, SF; Lin, LC; Wang, PS | 1 |
| Bizik, F; Blumberg, PM; Kedei, N; Kozikowski, AP; Pearce, LV; Petukhov, PA; Szabo, T | 1 |
| Liang, JY; Wang, QZ | 1 |
| Chiang, PC; Chueh, SC; Guh, JH; Huang, DM; Huang, YT; Teng, CM | 1 |
| Deng, HW; Du, YH; Hu, CP; Li, YJ; Peng, J; Rang, WQ; Xu, KP; Ye, F | 1 |
| Chang, YL; Guh, JH; Liao, CH; Lin, CH; Pai, HC; Pan, SL; Teng, CM | 1 |
| Aggarwal, BB; Kobayashi, Y; Takada, Y | 1 |
| Ikejima, T; Onodera, S; Tashiro, S; Wang, C; Wang, MW | 3 |
| Chen, E; Lee, CC; Lin, LC; Lin, S; Shyu, KG; Tsai, SC; Wang, BW | 1 |
| Benvenuti, S; Melegari, M; Pellati, F; Yoshizaki, F | 1 |
| Cai, XF; Choi, YH; Kim, HP; Kim, YS; Lee, JJ; Shin, EM | 1 |
| Li, C; Liao, Y; Liu, H; Liu, Y; Wen, D | 1 |
| Chen, CF; Chen, CM; Chen, KT; Ko, HC; Su, JP; Wang, GJ | 1 |
| Jeong, SH; Jung, EM; Kim, EJ; Kim, S; Kwon, TK; Lee, TJ; Park, JW; Park, SE; Yoo, YH | 1 |
| Chang, S; Chen, CF; Chen, CH; Chen, CM; Chen, KT; Hou, YC; Ko, HC; Liou, KT; Shen, YC; Wang, WY; Wang, YH | 1 |
| Bae, EA; Cai, XF; Kim, DH; Lee, JJ; Shin, YW | 1 |
| Chen, MJ; Hsu, JM; Kan, SF; Pu, HF; Wang, PS; Yu, CH | 1 |
| Gao, HM; Hong, YM; Wang, JY; Wang, WH; Wang, ZM | 1 |
| Kobayashi, Y; Kontani, Y; Mori, N; Sato, Y; Wang, T; Wang, Y; Yamashita, H | 1 |
| Ikejima, T; Onodera, S; Tashino, S; Wu, LJ; Yang, J | 3 |
| Ikejima, T; Onodera, S; Tashiro, S; Wu, LJ; Yang, J | 1 |
| Han, X; Peng, JY; Qi, Y; Wang, XN; Xu, LN; Xu, YW; Yin, LH | 1 |
| Teng, J; Wang, Y; Xu, W; Yang, XW | 1 |
| Deng, L; Hu, HY; Song, ZY; Zhang, MX | 1 |
| Chen, K; Lei, Q; Shi, J; Yan, J; Yang, D; Zhang, Y; Zhao, J; Zhao, X | 1 |
| Chang, YL; Guh, JH; Huang, DY; Liao, CH; Liu, YN; Pan, SL; Peng, CY; Teng, CM | 1 |
| Heo, SK; Noh, EK; Park, SD; Yi, HS; Yun, HJ | 1 |
| Chan, AL; Chang, WS; Chen, CE; Chen, LM; Hwang, JL; Lee, CM; Lin, CM | 1 |
| Hu, C; Jiang, J | 1 |
| Chen, AQ; Liu, B; Yang, ZG | 1 |
| Chao, HL; Wang, PS; Wang, SW; Yu, PL | 1 |
| Du, M; Jin, R; Kang, C; Li, J; Li, M; Liu, S | 1 |
| Davies, GE; Fahmy, H; Hu, Y; Zjawiony, JK | 1 |
| Wang, T; Wang, Y; Yamashita, H | 1 |
| Bak, EJ; Cha, JH; Kim, JM; Park, HG; Yoo, YJ | 1 |
| Li, S; Wang, C; Wang, MW | 1 |
| Feng, W; Gao, H; Gong, M; Song, Y; Wang, W; Wang, Z; Yan, L; Zhang, Q; Zhu, J | 1 |
| Kang, C; Li, M; Liu, S; Tong, H; Wang, Y; Yin, W; Zhou, Z | 1 |
| Chen, MC; Chi, CW; Ho, LL; Kan, SF; Lee, CH; Lin, LC; Pu, HF; Wang, PS; Wang, SW; Yu, CH | 1 |
| Chen, CE; Chen, CS; Hwang, J; Lai, ZY; Lin, CM; Lin, LW; Tsai, HP; Wu, JY | 1 |
| Fan, X; Liang, HP; Wang, X; Xu, X; Yang, X; Zhang, C | 1 |
| Chen, JJ; Hwang, TL; Kuo, YH; Wang, TY; Wu, JB | 1 |
| Fan, X; Liang, H; Tu, Y; Wang, X; Wang, Z; Yu, H; Zhang, C | 1 |
| Dong, G; Miao, Z; Sheng, C; Wang, S; Yao, J; Zhang, W | 1 |
| Chang, Y; Guo, F; Jiang, H; Liu, B; Wang, Q | 1 |
| Chao, DC; Ho, TY; Hsiang, CY; Kao, ST; Li, CC; Liang, JA; Lin, LJ; Lo, HY; Wu, SL | 1 |
| Gao, K; Liu, JN; Ma, CM; Qin, C; Quan, XZ; Wang, DM; Yuan, SM; Zhang, LF | 1 |
| He, S; Huang, H; Huang, Y; Li, Z; Liu, X; Xu, W; Zhang, H; Zhang, Y | 1 |
| Chang, CS; Chao, DC; Ho, TY; Hsiang, CY; Huang, HC; Kao, ST; Liang, JA; Lin, LJ; Wu, SL | 1 |
| Cheng, LC; Ching, LC; Kou, YR; Lee, TS; Pan, CC; Shyue, SK; Su, KH; Wei, J; Yu, YB | 1 |
| Chen, Y; Huang, Z; Liu, Y; Wu, Y; Yi, J | 1 |
| Davies, GE; Ehli, EA; Hu, Y; Hudziak, JJ | 1 |
| Li, J; Liu, Y; Ma, X | 1 |
| Miao, Z; Sheng, C; Zhang, W | 1 |
| Bi, W; Du, BY; Li, JF; Liu, XD; Tan, YH; Wu, YY; Zhu, LH | 1 |
| Feng, NP; Liu, Y; Shi, F; Wang, Z; Zhang, SJ; Zhang, YT; Zhao, JH; Zhong, YZ | 1 |
| Guo, RL; He, KW; Hu, YY | 1 |
| Chen, F; Ding, J; He, L; Li, Y; Peng, J; Xu, S; Zhang, J | 1 |
| Chen, H; Guo, HC; Lin, SZ; Liu, DL; Liu, HB; Ni, ZL; Tong, HF; Wang, ZH; Wei, WT | 1 |
| Cai, J; Li, W; Lin, C; Lin, G; Ma, J; Pan, J; Pan, X; Wang, X | 1 |
| Bubenyák, M | 1 |
| Khan, M; Ma, T; Rasul, A; Yang, H; Yu, B; Zhong, L | 1 |
| Bao, T; Dong, Y; Li, Y; Weng, X; Yang, Q; Zhang, Y; Zhu, X | 1 |
| Hu, CQ; Li, F; Yang, XW | 1 |
| Bligh, SW; Hartley, JA; Hartley, JM; Pan, X; Wang, Z; White, KN | 1 |
| Chen, CY; Ching, LC; Hou, HH; Kou, YR; Lee, TS; Shyue, SK; Su, KH | 1 |
| Chen, F; Ding, JS; Li, D; Li, S | 1 |
| Feng, NP; Huang, ZB; Liu, Y; Wang, Z; Zhang, SJ; Zhang, YT; Zhao, JH | 1 |
| Cao, YF; Fang, ZZ; Hong, M; Sun, HZ; Sun, XY | 1 |
| Dong, G; Guo, Z; Miao, Z; Sheng, C; Wang, S; Yao, J; Zhang, W; Zhang, Y | 1 |
| Chen, XX; Dai, JP; Li, KS; Li, WZ; Wang, GF; Xu, YX; Yang, JC; Zhang, L; Zhao, XF | 1 |
| Gong, W; Jin, H; Liang, H; Sun, L; Wang, Z; Yu, H; Zhang, L; Zhang, Y | 1 |
| Ching, LC; Kou, YR; Lee, HF; Lee, TS; Shyue, SK; Wei, J; Zhao, JF | 1 |
| Cai, X; Cao, P; Hu, C; Lu, W; Xu, X; Yang, J; Yu, Q | 1 |
| Fan, X; Liang, HP; Tu, YJ; Yang, X; Zhang, C | 1 |
| Chang, MC; Chen, CS; Lin, CM; Lin, HC; Tsai, HP; Wu, JY; Yang, CC; Yang, CH | 1 |
| Jiang, DF; Sun, C; Yang, HL; Zhang, XG | 1 |
| Chen, Y; Huang, Z; Liu, Y; Tang, X; Yi, J; Zhao, J | 1 |
| Cai, YY; Liu, CX; Si, DY; Xia, YY; Xu, HY | 1 |
| Gong, W; Jin, H; Liang, H; Wang, Z; Yu, H | 1 |
| Du, J; Lu, YY; Su, SB; Wang, XF; Zhang, H; Zhang, TL; Zhou, QM | 1 |
| Ding, G; Guo, Y; Lv, Y; Nie, G; Xu, L; Zhai, J | 1 |
| Guan, W; Liu, B; Qian, X; Shen, J; Wang, H; Wei, J; Yu, L; Yue, G; Zou, Z | 1 |
| Chen, KC; Chiu, WT; Hou, SY; Hsiao, SH; Kuei, HP; Liu, AJ; Shih, CM; Shih, YL; Wang, SH | 1 |
| Cheng, SC; Hsia, SM; Wang, KL; Wang, PS; Wang, SW; Yeh, JY | 1 |
| Appendino, G; De Petrocellis, L; Di Marzo, V; Fontana, G; Passarella, D; Sacchetti, A; Schiano Moriello, A | 1 |
| Liu, Y; Shi, HL; Wu, XJ; Xie, JQ | 1 |
| Caufin, S; Christodoulou, MS; Dalla Via, L; Dapiaggi, F; Fontana, G; Gia, OM; Jarho, E; Lahtela-Kakkonen, M; Lesma, G; Martinet, N; Minicone, F; Passarella, D; Pieraccini, S; Riva, B; Ronchetti, V; Sacchetti, A; Silvani, A; Sironi, M; Ventura, M; Zuco, V; Zunino, F | 1 |
| Grandjean, PW; La Bounty, P; Leutholtz, B; Schwarz, NA; Spillane, M; Willoughby, DS | 1 |
| Chen, Z; Huang, Y; Li, S; Song, H; Song, S; Wan, Y | 1 |
| Kontani, Y; Kusudo, T; Mori, N; Okamatsu, Y; Saito, M; Takeuchi, T; Wang, T; Yamashita, H; Yamashita, Y | 1 |
| Bi, Y; Huang, H; Liu, X; Ran, G; Wu, D; Yang, L; Zhang, M | 1 |
| Ivanova, B; Spiteller, M | 1 |
| Jin, HW; Qian, P; Yang, XW | 1 |
| He, D; Jin, X; Qu, S; Shi, Q; Zhang, T | 1 |
| Li, Z; Wei, J; Yuan, F | 1 |
| Chen, D; Jiang, DF; Li, WT; Sun, C; Yang, HL; Zhang, ZZ | 1 |
| Liu, L; Moore, DJ; Roongta, V; Wen, B | 1 |
| Darras, FH; Decker, M; Heilmann, J; Huang, G; Kling, B | 1 |
| Chen, M; Shi, Z; Wang, L; Wang, S; Wang, Y; Zhong, Z | 1 |
| Bao, J; Chen, F; Chen, M; He, C; Wang, L; Wang, S; Wang, Y; Zou, L | 1 |
| Bai, X; Chen, L; Cui, L; Wang, L; Zhang, J; Zhang, L; Zhang, X; Zhao, T; Zhao, X; Zhao, Y | 1 |
| Chen, CH; Chen, YC; Chien, CC; Ko, CH; Shen, SC; Wu, MS; Yang, LL | 1 |
| Fang, C; Hu, J; Sun, L; Tan, Q; Wang, H; Ye, M; Zhang, J; Zhang, L; Zhao, D | 1 |
| Chen, ZF; Guo, WW; Li, Z; Liu, LH; Wu, GY; Xie, JY; Yi, JY; Zhang, L; Zhang, ZJ | 1 |
| Liao, H; Liu, Y; You, Z; Zahng, J | 1 |
| Chen, DP; Lin, Y; Liu, FF; Lv, BC; Peng, JY; Wang, JY; Xiong, YJ | 1 |
| Fu, Q; Jin, Y; Li, K; Li, Z; Liang, T | 1 |
| Domonkos, C; Fitos, I; Visy, J; Zsila, F | 1 |
| Chen, D; Hu, J; Jiang, R; Tan, Q; Zhang, J; Zhu, B | 1 |
| Bi, Y; Fan, L; Gao, H; Khan, M; Qazi, JI | 1 |
| Fan, X; Fang, C; Liu, L; Luo, J; Qi, D; Tan, Q; Zhang, J | 1 |
| Cai, Q; Li, W; Shi, S; Wang, Q; Wei, J; Wei, R; Zhang, Y; Zhao, W | 1 |
| Missler, SR; Rebhun, JF; Roloff, SJ; Velliquette, RA | 1 |
| Gong, GQ; Jiang, ML; Li, YZ; Wang, XH; Yan, W; Zhang, ZX | 1 |
| Chang, WL; Chen, CS; Guh, JH; Yu, CC | 1 |
| Chen, T; Qin, X; Wu, H; Xiong, H; Zhu, F; Zou, Y | 1 |
| Cho, SD; Kim, Y; Lee, JS; Sachita, K; Yu, HJ | 1 |
| Han, S; Jung, Y; Kang, C; Kim, E; Kim, W; Kwon, T; Lee, S; Yang, HJ; Youn, B; Youn, H | 1 |
| Chen, L; Deng, ZL; He, BC; Ke, ZY; Liu, Y; Meng, ZJ; Pi, CJ; Shu, KJ; Wu, N; Yin, LJ; Zhang, RX; Zou, X | 1 |
| Aoki, S; Dai, Y; Iwaoka, E; Kogure, Y; Matsuyoshi, N; Noguchi, K; Wang, S; Yamamoto, S | 1 |
| Gong, S; Ma, C; Wang, S; Zhao, Z | 1 |
| Chen, S; Dong, G; Fang, K; Li, J; Liu, N; Miao, Z; Sheng, C; Wang, S; Yao, J; Zhang, W | 1 |
| Dhulap, S; Gavaraskar, K; Hirwani, RR | 1 |
| Cheng, Y; Li, X; Wang, X; Xue, H; Yue, Y; Zhang, W | 1 |
| Gao, Y; Guo, L; Li, G; Liang, S; Liu, S; Lv, Q; Wang, S; Xie, J; Xu, H; Xue, Y; Ying, M; Zhang, X; Zou, L | 1 |
| Chen, B; Hu, H; Huang, M; Lei, J; Li, Y; Lu, J; Wang, Z; Xie, W; Yu, L; Zeng, K; Zeng, S | 1 |
| Feng, S; Hong, D; Wang, Q; Wang, Z; Wei, L; Wen, Z | 1 |
| Chen, QZ; Chen, ZH; He, BC; Huang, J; Li, Y; Ren, CM; Shao, Y; Sun, WJ; Wang, DX; Wu, K; Wu, QX; Yu, Y; Yuan, SX; Zeng, YH | 1 |
| Ai, P; Li, J; Peng, X; Wang, L; Zeng, Y; Zhang, Q | 1 |
| Qiang, WA; Tan, W; Wang, SP; Wang, YT; Zhong, ZF | 1 |
| Chen, DL; Feng, ZQ; Li, J; Liao, K; Luo, N; Shi, QQ; Zhao, LC | 1 |
| Fu, JM; Li, RF; Lv, XZ; Pan, YY; Rao, DP; Yu, KY; Zhang, DT | 1 |
| Chen, ZS; Deng, WL; Fu, XL; Huang, JP; Ji, Q; Li, Q; Liu, X; Sui, H; Wen, HT; Zhang, YL; Zhou, LH; Zhu, HR | 1 |
| Dong, F; Liu, X; Luan, C; Luan, S; Shao, H; Sun, C; Zhang, G | 1 |
| Chen, S; Ge, X; Liang, T; Liu, C; Liu, M | 1 |
| Gong, M; He, R; He, S; Lu, X; Pan, X; Wu, Y; Xu, Y | 1 |
| Han, S; Jeong, D; Jung, Y; Kang, M; Kim, WY; Lee, H; Oh, SH; Ryu, JH; Woo, JK; Yoo, YJ | 1 |
| Dong, JY; Li, YL; Lin, NM; Mao, SY; Pan, JP; Pan, YN; Sun, J; Wu, WJ; Zhang, C; Zhang, DY; Zhao, YM | 1 |
| Bi, Y; Huang, H; Liu, X; Wang, LH; Yang, L | 1 |
| Chen, RJ; Ge, NY; Hao, C; Zhang, DF; Zhang, Y; Zhang, YT; Zhu, GH | 1 |
| Chen, TC; Chen, YC; Chien, CC; Wu, MS | 1 |
| Feng, J; Lei, TT; Liu, HM; Zhang, JQ; Zhang, X | 1 |
| Dai, Y; Kogure, Y; Noguchi, K; Wang, S; Yamamoto, S; Zhang, W | 1 |
| Gao, X; Guo, Q; Han, Y; Hu, C; Liu, M; Wang, J; Wang, Y; Zhang, K | 1 |
| Cheng, KG; Han, T; Hu, X; Hua, HM; Li, DH; Li, ZL; Tian, KT; Zhao, N | 1 |
| He, ZB; Li, HY; Liu, F; Liu, JS; Yang, WD | 1 |
| Feng, H; Guo, B; Kong, X; Wu, B | 1 |
| Agarwal, R; Mohan, V; Singh, RP | 1 |
| Liu, Q; Liu, Y; Luo, F; Shi, L; Yang, F; Zhang, F; Zou, M | 1 |
| Gao, B; Guo, H; Liu, D; Ren, H; Santos, HA; Xu, F; You, M; Zhang, H; Zhang, X | 1 |
| Cao, Z; Jin, X; Li, W; Wei, L | 1 |
| Chen, YC; Chien, CC; Chiu, WT; Wu, WS | 1 |
| Lin, L; Qi, J; Ren, L; Wang, Y; Wen, L | 1 |
| Chen, SY; Ge, X; Liang, TM; Liu, C; Liu, M | 1 |
| Tan, Q; Zhang, J | 1 |
| Li, H; Liu, JG; Wang, ZY; Yang, HM | 1 |
| Jin, DY; Lou, WH; Rong, YF; Wu, W; Xu, XF; Zhang, L | 1 |
| Gong, XL; Huang, C; Liu, H; Wen, B; Wu, LY | 1 |
| Ji, L; Liang, T; Shen, Y; Shi, L; Xu, L; Yang, F; Zhang, G; Zhu, F | 1 |
| Chiang, SY; Chou, ST; Ho, TY; Hsiang, CY; Hsieh, CL; Huang, HF; Lai, MT; Lo, HY | 1 |
| Chin, CC; Huang, YC; Kuo, YH; Lee, YR; Li, JM; Shi, CS | 1 |
| Fan, X; Liang, HP; Luo, L; Ma, W; Sun, Y; Tang, WQ; Yan, J; Yang, X; Yu, J; Zhu, JY | 1 |
| Chen, YC; Chien, CC; Chiu, WT; Liu, KH; Wu, WS | 1 |
| Feng, NP; He, ZH; Li, Z; Xia, Q; Zhang, HY; Zhang, K; Zhang, YT; Zhao, JH | 1 |
| Cui, K; Lei, L; Li, S; Ma, L; Yang, W; Ye, Z | 1 |
| Chang, CJ; Hu, CY; Lin, CH; Su, YC; Wu, CL; Wu, HT | 1 |
| Cheng, S; Du, YM; Hou, XD; Liu, XM; Yuan, XL; Zhang, P; Zhang, ZF | 1 |
| Han, T; Hu, X; Hua, H; Jiao, R; Li, D; Li, Z; Liu, W; Wang, Y; Xu, F; Xue, J | 1 |
| Liu, L; Ni, H; Ren, F; Ren, J; Shen, T; Wei, H; Wei, J; Xu, S; Zhou, X | 1 |
| Li, Y; Peng, Y; Xi, F; Yang, G; Yao, X; Yu, T; Zhao, C | 1 |
| Chen, JL; Hu, X; Li, QY; Li, YL; Rao, MJ; Wu, LW; Yan, W; Zhang, B; Zhang, C; Zhang, NY | 1 |
| Bisson, WH; Gonzalez, FJ; Krausz, KW; Sun, D; Xie, C; Yagai, T; Yan, T; Yang, X; Zhang, L; Zhang, Y; Zheng, Y | 1 |
| Li, Z; Liu, X; Lu, J; Wang, C; Wang, D; Wang, J; Zhang, J; Zhang, Y | 1 |
| Hu, X; Li, Y; Liu, S; Yan, S; Yang, L; Zeng, M; Zhang, J; Zhang, Y; Zhao, H; Zhao, J | 1 |
| Atanasov, AG; Dirsch, VM; Eftekhari, P; Heiss, EH; Ignatova, ID; Ladurner, A; Palme, V; Schachner, D; Schilcher, N; Stangl, H; Wang, L | 1 |
| Luo, HS; Ren, HX; Tang, QC; Xia, H; Yan, L | 1 |
| Chan, HL; Chou, HC; Chuang, HH; Lee, YR; Liao, EC; Lin, LH; Lu, CH; Su, YC; Tsai, YT; Wei, YS; Yang, YT; Yu, HI | 1 |
| Hu, J; Zhou, Y | 1 |
| Chen, X; Li, H; Zhou, S | 1 |
| Chu, C; Hu, X; Hua, H; Jia, Y; Li, D; Li, X; Wang, X; Xu, F | 1 |
| Chen, DL; Chen, Y; Guo, XX; Jiang, R; Li, DY; Li, J; Li, XP; Lyu, XT; Lyu, YW; Ran, JH; Tian, K; Yuan, DZ; Zhou, P | 1 |
| Choi, MG; Ihm, SH; Kang, JG; Kim, CS; Kim, SH; Lee, SJ | 2 |
| Feng, NP; He, ZH; Li, YY; Shen, LN; Wang, Z; Xia, Q; Zhang, YT | 1 |
| Gong, X; Huang, C; Wang, X; Yang, W | 1 |
| Chen, TY; Feng, Y; Li, NX; Wu, M; Yang, Q; Yin, HL | 1 |
| Cao, H; Cao, Y; Fu, Y; Jing, Y; Li, Y; Liu, J; Lu, X; Shen, P; Yuan, X; Zhang, N; Zhang, Z; Zhu, K | 1 |
| Aisa, HA; Cao, JG; Huang, GZ; Liu, FZ; Nie, LF; Wang, SS; Xiamuxi, H | 1 |
| Li, JJ; Tian, KM; Xu, SW | 1 |
| Feng, J; Geng, R; Jin, Y; Liu, Y; Sun, J; Wei, Y; Zhao, F; Zhao, L; Zhu, B | 1 |
| Chen, Y; Wu, P | 1 |
| Deng, JD; Hu, XL; Jiang, Y; Lei, S; Tan, W; Wang, Z; Wen, HX; Zhang, HH | 1 |
| Chen, DL; Chen, Y; Guo, XX; Jiang, R; Li, J; Li, XP; Lv, XT; Lv, YW; Ran, JH; Tian, K; Yuan, DZ; Zhou, P | 1 |
| Ma, Y; Su, Q; Wang, J; Wang, S; Wu, M; Yin, H | 1 |
| Chen, J; Sun, Y; Wang, J; Wu, Y; Zhang, Y; Zhao, J | 1 |
| Eraslan, E; Polat, E; Tanyeli, A; Yetim, Z | 1 |
| Chen, Z; Liu, Y; Mao, Z; Zhou, W | 1 |
| Cai, G; Cai, J; Gao, R; Ji, Q; Li, C; Li, Q; Song, D; Sui, H; Teng, P; Wang, Y; Zhou, L | 1 |
| Ge, K; Jia, C; Lu, J; Zhu, H | 1 |
| Chen, Z; Zhang, B | 1 |
| Choi, S; Kim, H; Kim, WY; Lee, H; Lee, JH; Yu, J; Yu, Y | 1 |
| Chen, S; Cheng, J; Dong, G; Fang, K; Huang, Y; Li, Y; Sheng, C; Wang, L; Wu, S | 1 |
| Chen, T; Fu, Y; Peng, F; Tian, M; Wang, Y; Yang, W | 1 |
| Cui, MZ; Deng, Y; He, BC; Hu, Y; Huang, J; Li, FS; Li, L; Li, PP; Shu, DZ; Zeng, JR | 1 |
| Chen, H; Hong, Z; Jamshed, MB; Liao, Y; Tong, H; Wang, J; Wang, Z; Zhang, Q; Zheng, P; Zhou, B | 1 |
| Huang, Y; Lu, L; Qi, X; Su, T; Wang, Y; Yang, X; Zhang, Y | 1 |
| Gao, WL; Li, YT; Lu, M; Wang, J; Yin, L; Yin, ZS; Zhang, H | 1 |
| Chen, DL; Guo, XX; Hu, L; Jiang, R; Li, DY; Li, J; Li, LS; Ran, JH; Tang, JF; Xu, K; Zeng, D; Zhao, S; Zhou, P | 1 |
| Ge, J; Li, X; Liu, R; Sun, R; Zhang, J; Zheng, Q | 1 |
| Guan, X; Vong, CT; Wang, Y; Xiao, J; Zhao, J; Zheng, X; Zhong, Z | 1 |
| Chen, J; Li, C; Li, Z; Lin, J; Lu, H; Wu, Z; Yang, X; Zhang, X; Zhang, Y | 1 |
| Ahn, KS; Alharbi, SA; Blough, BE; Chinnathambi, A; Hwang, ST; Namjoshi, OA; Narula, AS; Um, JY | 1 |
| Choi, Y; Lin, H; Lin, L; Michniak-Kohn, B | 1 |
| Du, J; Fu, S; Gao, X; He, D; Hu, G; Huang, B; Liu, D; Meng, T; Su, Y; Zhang, Y; Zhou, A | 1 |
| Chen, YD; Han, B; Li, P; Liao, QF; Lin, L; Lin, YX; Tian, X; Wang, MX; Xie, ZY; Zhong, YP | 1 |
| Deng, YG; Li, GF; Liu, SJ; Lyu, XL; Zhang, SC; Zhao, BX; Zhu, YL | 1 |
| Li, X; Song, J; Sun, Q; Xie, L | 1 |
| Huang, C; Huang, WX; Liang, BJ; Liu, HS; Shao, YW; Shen, WZ; Wang, XL; Xiang, KM; Zhang, FJ | 1 |
| Chen, X; Huang, J; Lu, Y; Wang, R; Wang, Y; Xun, D; Zhao, L; Zheng, R | 1 |
| Guo, J; Huang, Q; Liu, L; Wang, X; Wang, Y; Xi, H | 1 |
| Chang, C; Fan, XX; Huang, JM; Jiang, ZB; Lai, HL; Leung, EL; Wang, MF; Wang, W; Wu, QB; Xie, C; Xie, YJ; Yao, XJ; Zhang, YZ | 1 |
| Chang, GL; Liu, G; Ye, B; Yu, DD; Yu, XM; Zhang, J; Zhang, L; Zhao, MS; Zhu, LQ | 1 |
| Chen, DL; Hu, L; Huang, SY; Jiang, R; Li, DY; Li, GL; Li, J; Li, LS; Li, XP; Ran, JH; Wang, YP; Zeng, D; Zhao, S; Zhou, P | 1 |
| Han, BW; Hong, S; Hyun, SY; Le, HT; Lee, HY; Lim, Y; Min, HY; Nguyen, YTK; Pei, H; Song, I | 1 |
| Cui, Y; Wang, J; Wang, Q; Wu, X | 1 |
| He, D; Lei, XY; Li, Z; Peng, J; Peng, Y; Tang, G; Xie, ZZ; Xiong, R | 1 |
| An, P; Ding, Y; Luo, H; Ren, H; Tan, W; Yuan, F | 1 |
| Han, B; Huang, W; Li, X; Peng, C; Xie, X; Ye, C; Zhang, N; Zhao, Q; Zhu, HP | 1 |
| Chen, S; Dong, G; Huang, Y; Liu, D; Ma, Z; Sheng, C; Wan, K; Zhu, F | 1 |
| Kim, JB; Kim, SH; Lee, P; Yang, JY | 1 |
| Cui, YL; Qiao, T; Qiu, C; Wang, Y; Xu, D | 1 |
| Bi, K; Chen, S; Dong, G; Huang, Y; Li, Y; Sheng, C; Wu, S | 1 |
| Chou, CH; Yang, CR | 1 |
| Hu, X; Li, N; Liu, H; Qi, D; Wang, T; Zhang, J; Zhang, X; Zhong, C | 1 |
| Chen, P; Jia, J; Jia, Y; Li, H; Wang, X; Wang, Y; Xiu, R; Xue, Y; Zhang, G; Zhang, X; Zhao, Z | 1 |
| Deng, J; Fan, X; Hao, X; Lei, F; Li, J; Liang, Y; Liang, Z; Liu, D; Shi, T; Wang, Z; Wen, H; Zhang, H | 1 |
| Chen, Y; Fu, S; Guo, W; Hou, S; Hu, G; Liu, J; Ran, X; Wang, H; Yang, Y; Yang, Z | 1 |
| Lou, Y; Ren, L; Sun, M | 1 |
| Chu, QR; Du, SS; He, YH; Li, HX; Liu, YQ; Tang, C; Wang, JR; Wu, TL; Yang, CJ; Zhang, ZJ | 1 |
| Cheng, P; Fan, J; Liu, C; Wang, X; Xu, C; Zhang, X; Zhao, X | 1 |
| Gao, Y; Lian, WY; Wang, YG; Yang, CQ | 1 |
| Deng, J; Lei, F; Li, J; Liang, Z; Shi, T; Wang, Y; Wang, Z; Yang, X; Zhang, H | 1 |
| Chen, ZS; Li, D; Qiu, Y; Wu, L; Xu, J; Xu, S; Yang, DH; Yao, H; Zhou, M | 1 |
| Atanasov, AG; Dirsch, VM; Heiß, EH; Hou, X; Malainer, C; Wang, K; Wang, L | 1 |
| Gao, YD; Li, LD; Li, YZ; Shan, DP; Wang, Q; Wang, S; Zhang, T; Zhu, A | 1 |
| Guo, W; Lv, H; Wang, X; Zhang, J; Zhang, T; Zhao, C | 1 |
| Fan, M; Yao, L | 1 |
| Bae, SJ; Kim, YW; Song, YR; Yun, UJ | 1 |
| Dong, G; Liang, H; Liu, D; Meng, X; Sheng, C; Wu, S; Zhu, F | 1 |
| Chen, S; Li, F; Liu, J; Shi, Y; Wang, Y; Wen, W | 1 |
| Jiang, X; Li, D; Li, Y; Liu, W; Zhao, Q | 1 |
| Chen, S; Liang, H; Liu, D; Sheng, C; Wang, W; Zhu, F | 1 |
| Dai, Y; Shen, T; Zhou, J; Zhu, W | 1 |
| Chen, F; Liao, J; Lu, Q; Niu, C; Wang, H; Wang, S; Yu, Y | 1 |
| Deng, J; Lei, F; Li, J; Li, R; Liang, Z; Shi, T; Wang, S; Wang, Y; Wang, Z; Zhang, H | 1 |
| Kuai, J; Zhang, N | 1 |
| Biswal, BK; Panda, M | 1 |
| Leng, M; Li, L; Meng, Z; Peng, Y; Wan, W; Wang, J; Wang, Q; Wu, K; Yang, L; Yang, X; Ye, Y; Zou, J | 1 |
| Ling, X; Lu, W; Ni, H; Rui, Q; Wang, W; Xu, M | 1 |
| Guo, H; Jin, R; Liu, J; Tang, Y; Wang, Y; Yan, H; Zhou, J | 1 |
13 review(s) available for quinazolines and evodiamine
| Article | Year |
|---|---|
[Advances in pharmacological study of Evodia rutaecarpa and its effective constituents].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drugs, Chinese Herbal; Evodia; Fruit; Gastrointestinal Motility; Humans; Plant Extracts; Plants, Medicinal; Quinazolines | 2003 |
Evodiamine: a novel anti-cancer alkaloid from Evodia rutaecarpa.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Evodia; Humans; Medicine, Chinese Traditional; Neoplasms; Neovascularization, Pathologic; Plant Extracts; Quinazolines | 2009 |
New strategies in the discovery of novel non-camptothecin topoisomerase I inhibitors.
Topics: Carbazoles; DNA Topoisomerases, Type I; Drug Design; Drug Evaluation, Preclinical; Enzyme Activation; Humans; Isoquinolines; Phenanthridines; Pyridines; Quinazolines; Structure-Activity Relationship; Topoisomerase I Inhibitors | 2011 |
Pharmacological actions of multi-target-directed evodiamine.
Topics: Animals; Humans; Ligands; Models, Molecular; Proteins; Quinazolines | 2013 |
Therapeutic and cosmetic applications of Evodiamine and its derivatives--A patent review.
Topics: Alkaloids; Animals; Autoimmune Diseases; Cell Line, Tumor; Central Nervous System Diseases; Cosmetics; Evodia; Fruit; Humans; Inflammation; Metabolic Diseases; Molecular Structure; Neoplasms; Patents as Topic; Quinazolines | 2015 |
Evodiamine and Its Role in Chronic Diseases.
Topics: Analgesics; Animals; Anti-Allergic Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Obesity Agents; Antineoplastic Agents, Phytogenic; Chronic Disease; Disease Models, Animal; Evodia; Humans; Molecular Structure; Phytotherapy; Plants, Medicinal; Quinazolines; Signal Transduction; Structure-Activity Relationship | 2016 |
Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review.
Topics: Abietanes; Alkaloids; Alzheimer Disease; Curcuma; Curcumin; Drugs, Chinese Herbal; Epimedium; Evodia; Flavonoids; Ginsenosides; Humans; Huperzia; Panax; Phytotherapy; Plant Extracts; Quinazolines; Salvia miltiorrhiza; Scutellaria baicalensis; Sesquiterpenes | 2016 |
Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Cell Proliferation; Humans; Neoplasms; Quinazolines | 2018 |
Rutaecarpine: A promising cardiovascular protective alkaloid from Evodia rutaecarpa (Wu Zhu Yu).
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Antioxidants; Cardiotonic Agents; Cardiovascular Diseases; Evodia; Humans; Hypolipidemic Agents; Indole Alkaloids; Platelet Aggregation Inhibitors; Quinazolines; Vasodilator Agents | 2019 |
Evodiamine and rutaecarpine from Tetradium ruticarpum in the treatment of liver diseases.
Topics: Animals; Evodia; Humans; Indole Alkaloids; Liver Diseases; Plants, Medicinal; Quinazolines | 2020 |
Evodiamine: A review of its pharmacology, toxicity, pharmacokinetics and preparation researches.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Drugs, Chinese Herbal; Ethnopharmacology; Humans; Medicine, Chinese Traditional; Quinazolines | 2020 |
The Synthesis, Structural Modification and Mode of Anticancer Action of Evodiamine: A Review.
Topics: Alkaloids; Evodia; Humans; Patents as Topic; Plant Extracts; Quinazolines | 2022 |
Evodiamine: A Privileged Structure with Broad-ranging Biological Activities.
Topics: Alkaloids; Butyrylcholinesterase; Cyclic Nucleotide Phosphodiesterases, Type 5; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Female; Histone Deacetylases; Humans; Quinazolines; Quinolones; Sirtuins; Tubulin | 2022 |
1 trial(s) available for quinazolines and evodiamine
| Article | Year |
|---|---|
Capsaicin and evodiamine ingestion does not augment energy expenditure and fat oxidation at rest or after moderately-intense exercise.
Topics: Adipose Tissue; Adolescent; Adult; Capsaicin; Capsicum; Cross-Over Studies; Energy Metabolism; Evodia; Exercise; Humans; Lipid Metabolism; Male; Oxidation-Reduction; Oxygen Consumption; Physical Exertion; Plant Extracts; Quinazolines; Rest; Thermogenesis; Young Adult | 2013 |
289 other study(ies) available for quinazolines and evodiamine
| Article | Year |
|---|---|
The vasorelaxant effect of evodiamine in rat isolated mesenteric arteries: mode of action.
Topics: Animals; Calcium; Calcium Channels; Calcium Chloride; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Plant Extracts; Potassium Channels; Quinazolines; Rats; Rats, Sprague-Dawley; Tetraethylammonium Compounds; Vasodilator Agents | 1992 |
[On the evaluation of the preparation of Chinese medicinal prescriptions. VI. The changes of the alkaloid contents by processing of Evodia fruit].
Topics: Alkaloids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Humans; Indole Alkaloids; Plant Extracts; Quinazolines; Quinolones; Taste | 1991 |
Antianoxic action of evodiamine, an alkaloid in Evodia rutaecarpa fruit.
Topics: Alkaloids; Animals; Anticonvulsants; Atmospheric Pressure; Dihydroergotoxine; Hypoxia; Male; Mice; Pentobarbital; Plant Extracts; Plants, Medicinal; Potassium Cyanide; Quinazolines; Sleep; Vinca Alkaloids | 1989 |
Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae).
Topics: Animals; Cardiotonic Agents; Guinea Pigs; In Vitro Techniques; Japan; Myocardial Contraction; Plant Extracts; Plants, Medicinal; Quinazolines | 1986 |
High-performance liquid chromatographic determination of evodiamine in rat plasma: application to pharmacokinetic studies.
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Injections, Intravenous; Plant Extracts; Quinazolines; Rats; Spectrophotometry, Ultraviolet | 1995 |
Thermoregulatory effects of alkaloids isolated from Wu-chu-yu in afebrile and febrile rats.
Topics: Alkaloids; Animals; Body Temperature Regulation; Calcium; Cardiotonic Agents; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fever; Lipopolysaccharides; Oxygen Consumption; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Salmonella typhi | 1995 |
Pharmacological properties of galenical preparation. XVI. Pharmacokinetics of evodiamine and the metabolite in rats.
Topics: Adipose Tissue; Administration, Oral; Animals; Bile; Kidney; Liver; Lung; Male; Myocardium; Plant Extracts; Quinazolines; Rats; Rats, Wistar; Tissue Distribution | 1993 |
Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa.
Topics: Alkaloids; Animals; Aorta, Thoracic; Arginine; Calcium Channel Blockers; Enzyme Inhibitors; In Vitro Techniques; Indole Alkaloids; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Plant Extracts; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Vasodilator Agents | 1996 |
[A simultaneous determination of evodiamine and rutaecarpine in oriental pharmaceutical decoctions containing Evodia fruit by ion-pair high-performance liquid chromatography].
Topics: Alkaloids; Cardiotonic Agents; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Indole Alkaloids; Plant Extracts; Quinazolines | 1996 |
Antinociceptive activities of 70% methanol extract of evodiae fructus (fruit of Evodia rutaecarpa var. bodinieri) and its alkaloidal components.
Topics: Alkaloids; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; China; Chromatography, High Pressure Liquid; Indole Alkaloids; Limonins; Male; Mice; Mice, Inbred Strains; Motor Activity; Pain Measurement; Plant Extracts; Plants, Medicinal; Quinazolines; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Triterpenes; Vasodilator Agents | 1997 |
Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages.
Topics: Alkaloids; Animals; Cells, Cultured; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Plant Extracts; Quinazolines | 1997 |
Effect of evodiamine on catecholamine secretion from bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Catecholamines; Cattle; Plant Extracts; Quinazolines; Vasodilator Agents | 1997 |
Effects of evodiamine on the secretion of testosterone in rat testicular interstitial cells.
Topics: Animals; Cyclic AMP; Male; Plant Extracts; Prodrugs; Quinazolines; Rats; Rats, Sprague-Dawley; Steroids; Testis; Testosterone | 1999 |
The bronchoconstrictive action of evodiamine, an indoloquinazoline alkaloid isolated from the fruits of Evodia rutaecarpa, on guinea-pig isolated bronchus: possible involvement on vanilloid receptors.
Topics: Animals; Bronchi; Bronchoconstriction; Guinea Pigs; In Vitro Techniques; Male; Plant Extracts; Plants; Quinazolines; Receptors, Drug | 2000 |
[Comparison of 4 extraction methods of chemical constituents in medicinal tea sishen chaji].
Topics: Cyclooctanes; Drug Combinations; Drugs, Chinese Herbal; Ficusin; Lignans; Plant Extracts; Polycyclic Compounds; Quinazolines; Technology, Pharmaceutical | 1997 |
The positive inotropic and chronotropic effects of evodiamine and rutaecarpine, indoloquinazoline alkaloids isolated from the fruits of Evodia rutaecarpa, on the guinea-pig isolated right atria: possible involvement of vanilloid receptors.
Topics: Alkaloids; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cardiotonic Agents; Dose-Response Relationship, Drug; Fruit; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Indole Alkaloids; Male; Myocardial Contraction; Plant Extracts; Platelet Aggregation Inhibitors; Purinergic Antagonists; Pyridoxal Phosphate; Quinazolines; Receptors, Drug; Rosales; Ruthenium Red; Stimulation, Chemical | 2001 |
Inhibitory effects of evodiamine on in vitro invasion and experimental lung metastasis of murine colon cancer cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Cell Division; Colonic Neoplasms; Female; Lung; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Plant Extracts; Quinazolines; Tumor Cells, Cultured | 2001 |
Inhibitory effect of evodiamine on aldosterone release by Zona glomerulosa cells in male rats.
Topics: Aldosterone; Angiotensin II; Animals; Male; Mineralocorticoid Receptor Antagonists; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Zona Glomerulosa | 2001 |
Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist.
Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Body Temperature; Body Weight; Capsaicin; Cholesterol; Fatty Acids, Nonesterified; Fruit; Japan; Lipid Metabolism; Lipolysis; Liver; Male; Medicine, East Asian Traditional; Mice; Mice, Inbred C3H; Obesity; Phytotherapy; Plant Extracts; Plants, Medicinal; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rutaceae; Triglycerides | 2001 |
The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.
Topics: Alkaloids; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; In Vitro Techniques; Indole Alkaloids; Kinetics; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidoreductases; Plant Extracts; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Theophylline | 2002 |
Pharmacological profile of evodiamine in isolated rabbit corpus cavernosum.
Topics: Aging; Animals; Colforsin; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle Relaxation; Nitric Oxide Donors; Nitroprusside; Nucleotides, Cyclic; Penis; Plant Extracts; Potassium; Potassium Channel Blockers; Quinazolines; Rabbits | 2002 |
Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice.
Topics: Alkaloids; Animals; Cell Fractionation; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Drugs, Chinese Herbal; Glucuronosyltransferase; Glutathione Transferase; Humans; Indole Alkaloids; Liver; Male; Methanol; Mice; Mice, Inbred C57BL; Oxazines; Plant Extracts; Plants, Medicinal; Quinazolines; Rutaceae | 2002 |
Anti-invasive and metastatic activities of evodiamine.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Lewis Lung; Cell Movement; Colonic Neoplasms; Evodia; Female; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Plant Extracts; Quinazolines | 2002 |
Effects of evodiamine on gastrointestinal motility in male rats.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Gastric Emptying; Gastrointestinal Motility; Gastrointestinal Transit; Injections, Intraperitoneal; Male; Phenylurea Compounds; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 2002 |
[Studies on evodiamine induced HeLa cell apoptosis].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspases; Evodia; Fruit; HeLa Cells; Humans; Plant Extracts; Plants, Medicinal; Quinazolines; Signal Transduction | 2002 |
Protective effects of calcitonin gene-related peptide-mediated evodiamine on guinea-pig cardiac anaphylaxis.
Topics: Anaphylaxis; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Cardiotonic Agents; Coronary Circulation; Evodia; Female; Guinea Pigs; Heart; Histamine; In Vitro Techniques; Male; Myocardium; Plant Extracts; Quinazolines; Time Factors; Ventricular Pressure | 2003 |
Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells.
Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Division; Cysteine Proteinase Inhibitors; Dactinomycin; DNA Fragmentation; Drug Screening Assays, Antitumor; Enzyme Activation; Evodia; Fibrosarcoma; Fluorouracil; Furans; Gene Expression Regulation, Neoplastic; Genes, bcl-2; HeLa Cells; Hepatocytes; Heterocyclic Compounds, 4 or More Rings; Humans; Indole Alkaloids; Leukemia, Monocytic, Acute; Leukocytes, Mononuclear; Melanoma; Mice; Mitochondria; Molecular Structure; Neoplasm Proteins; Oligopeptides; Plant Extracts; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Rats; Rats, Inbred BUF; Sarcoma 180; Tumor Cells, Cultured | 2003 |
[Determination of evodiamine and rutaecarpine in Evodia rutaecarpa (Juss.) Benth after compatibility with Coptis chinensis Franch].
Topics: Alkaloids; Coptis; Drug Combinations; Drugs, Chinese Herbal; Evodia; Indole Alkaloids; Plant Extracts; Plants, Medicinal; Quinazolines | 2001 |
The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Evodia; Fruit; Ileum; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Quinazolines | 2003 |
[On the blood pressure and respiratory effects of Yasuhico Asahima's evodiamine].
Topics: Alkaloids; Blood Pressure; Humans; Quinazolines; Respiration | 1962 |
Intracellular regulation of evodiamine-induced A375-S2 cell death.
Topics: Apoptosis; Caspases; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Evodia; Humans; Intracellular Fluid; Plant Extracts; Quinazolines | 2003 |
Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis.
Topics: Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Cycle; DNA Fragmentation; Dose-Response Relationship, Drug; Evodia; HeLa Cells; Humans; Melanoma; Mitogen-Activated Protein Kinases; Necrosis; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Plants, Medicinal; Quinazolines; Time Factors | 2004 |
[Evodiamine induces A375-S2 cell death through two different pathways].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase Inhibitors; Caspases; Cell Cycle; Cell Division; DNA Fragmentation; Dose-Response Relationship, Drug; Evodia; Humans; Melanoma; Plant Extracts; Quinazolines; Time Factors; Tumor Cells, Cultured | 2003 |
Atypical apoptosis in L929 cells induced by evodiamine isolated from Evodia rutaecarpa.
Topics: Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cell Survival; Evodia; Female; Fibrosarcoma; Fruit; Humans; Leukemia, Monocytic, Acute; Leukocytes, Mononuclear; Melanoma; Mice; Plant Extracts; Quinazolines; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2004 |
Inhibition by evodiamine of hepatocyte growth factor-induced invasion and migration of tumor cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Lewis Lung; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Evodia; Hepatocyte Growth Factor; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Plant Extracts; Quinazolines | 2004 |
Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspases; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Leukemia-Lymphoma, Adult T-Cell; Mitosis; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; T-Lymphocytes; Tubulin; Tumor Cells, Cultured | 2004 |
Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspases; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cell Line, Tumor; Coloring Agents; Dose-Response Relationship, Drug; Flow Cytometry; G2 Phase; Histones; Humans; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Male; Mitosis; Models, Chemical; Plant Extracts; Ploidies; Prostatic Neoplasms; Quinazolines; Tetrazolium Salts; Thiazoles; Time Factors | 2004 |
Evodiamine functions as an agonist for the vanilloid receptor TRPV1.
Topics: Animals; Calcium; Capsaicin; Cations, Divalent; CHO Cells; Cricetinae; Diterpenes; Ligands; Models, Biological; Molecular Conformation; Molecular Structure; Plant Extracts; Quinazolines; TRPV Cation Channels | 2004 |
[Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth].
Topics: Alkaloids; Carbolines; Evodia; Fruit; Indole Alkaloids; Molecular Structure; Plant Extracts; Plants, Medicinal; Quinazolines | 2004 |
Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine.
Topics: Apoptosis; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescent Antibody Technique; Humans; In Situ Nick-End Labeling; Microtubules; Mitosis; Plant Extracts; Polymers; Quinazolines; Tubulin; Tumor Cells, Cultured | 2005 |
Protective effects of evodiamine on myocardial ischemia-reperfusion injury in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cardiotonic Agents; Creatine Kinase; Evodia; Infusions, Intravenous; Male; Myocardial Reperfusion Injury; Myocardium; Phytotherapy; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2004 |
Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; Evodia; Female; Humans; Mice; Mice, Nude; Microtubules; Paclitaxel; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-raf; Quinazolines; Quinolines | 2005 |
Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion.
Topics: Active Transport, Cell Nucleus; Alkaloids; Annexin A5; Apoptosis; Carcinogens; Cell Line, Tumor; Cell Proliferation; Collagen; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Enzyme Activation; Evodia; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; I-kappa B Kinase; Immunohistochemistry; Immunoprecipitation; In Situ Nick-End Labeling; Indole Alkaloids; Inflammation; Laminin; MAP Kinase Signaling System; Microscopy, Fluorescence; Models, Chemical; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Protein Serine-Threonine Kinases; Proteoglycans; Quinazolines; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death.
Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Enzyme Inhibitors; Evodia; Gene Expression; Genes, p53; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; MAP Kinase Signaling System; Melanoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phytotherapy; Plant Extracts; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Sirtuin 1; Sirtuins; Staurosporine; Wortmannin | 2005 |
Evodiamine induced human melanoma A375-S2 cell death partially through interleukin 1 mediated pathway.
Topics: Cell Death; Cell Line, Tumor; DNA Damage; Humans; Interleukin-1; Melanoma; Plant Extracts; Quinazolines; Signal Transduction | 2005 |
Evodiamine inhibits in vitro angiogenesis: Implication for antitumorgenicity.
Topics: Angiogenesis Inhibitors; Capillaries; Cell Differentiation; Cell Line, Tumor; Cell Survival; Culture Media, Conditioned; Endothelial Cells; Endothelium, Vascular; Humans; Neovascularization, Pathologic; Plant Extracts; Quinazolines | 2006 |
[Effect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamine].
Topics: Apoptosis; Cell Line, Tumor; Evodia; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Melanoma; Plant Extracts; Plants, Medicinal; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Staurosporine | 2005 |
Development and validation of HPLC methods for the analysis of phenethylamine and indoloquinazoline alkaloids in Evodia species.
Topics: Chromatography, High Pressure Liquid; Evodia; Fruit; Indole Alkaloids; Medicine, Chinese Traditional; Molecular Structure; Phenethylamines; Plant Extracts; Plants, Medicinal; Polyethylene Glycols; Psychotropic Drugs; Quinazolines; Reproducibility of Results; Solvents; Stereoisomerism; Synephrine; Vasoconstrictor Agents; Vasodilator Agents | 2006 |
Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Calcimycin; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Evodia; Fruit; Indole Alkaloids; Leukotriene C4; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages; Mice; NF-kappa B; Plant Extracts; Quinazolines | 2006 |
Determination of evodiamine and rutecarpine in human serum by liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Evodia; Humans; Indole Alkaloids; Mass Spectrometry; Plant Extracts; Quinazolines; Reproducibility of Results; Tandem Mass Spectrometry | 2006 |
Chemical and biological comparisons on Evodia with two related species of different locations and conditions.
Topics: Alkaloids; Animals; Aorta; China; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Evodia; Female; Fruit; In Vitro Techniques; Indole Alkaloids; Male; Methanol; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Myometrium; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Species Specificity; Synephrine; Taiwan | 2006 |
Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells.
Topics: Apoptosis; Apoptosis Inducing Factor; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspases; Evodia; Humans; Kidney Neoplasms; Leukocytes, Mononuclear; Plant Extracts; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Reactive Oxygen Species; Transfection; U937 Cells | 2006 |
Anti-inflammatory effects and mechanisms of the ethanol extract of Evodia rutaecarpa and its bioactive components on neutrophils and microglial cells.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Cell Line; Ethanol; Evodia; Humans; Hydrazines; Indole Alkaloids; Mice; Microglia; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Picrates; Plant Extracts; Quinazolines; Reactive Oxygen Species; Synephrine; Tetradecanoylphorbol Acetate | 2007 |
In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents.
Topics: Alkaloids; Animals; Anti-Allergic Agents; Behavior, Animal; Cell Degranulation; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Evodia; Fruit; Indole Alkaloids; Interleukin-4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Plant Extracts; Pruritus; Quinazolines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2007 |
Anti-proliferative effects of evodiamine on human prostate cancer cell lines DU145 and PC3.
Topics: Androgens; Apoptosis; Carcinoma; Caspase 3; Caspase 8; Caspase 9; CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; Culture Media; Cyclin B; Cyclin B1; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Flow Cytometry; G2 Phase; Humans; L-Lactate Dehydrogenase; Male; Plant Extracts; Prostatic Neoplasms; Purines; Quinazolines; Roscovitine | 2007 |
[Methodological studies on equivalent relationship between granule for clinical prescription and clinical decoction of fructus evodiae].
Topics: Alkaloids; Animals; Drugs, Chinese Herbal; Evodia; Female; Fruit; Hot Temperature; Indole Alkaloids; Male; Mice; Mice, Inbred ICR; Pain Threshold; Plant Extracts; Plants, Medicinal; Quinazolines; Technology, Pharmaceutical | 2007 |
Evodiamine improves diet-induced obesity in a uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase/mitogen-activated protein kinase signaling.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Cell Differentiation; Diet, Atherogenic; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Insulin; Ion Channels; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Obesity; Plant Extracts; Quinazolines; Signal Transduction; Uncoupling Protein 1 | 2008 |
Critical roles of reactive oxygen species in mitochondrial permeability transition in mediating evodiamine-induced human melanoma A375-S2 cell apoptosis.
Topics: Acridine Orange; Apoptosis; Caspases; Cell Death; Cell Line, Tumor; Cell Nucleus; Cytosol; Humans; Melanoma; Membrane Potentials; Mitochondria; Models, Chemical; Permeability; Plant Extracts; Quinazolines; Reactive Oxygen Species | 2007 |
Nitric oxide activated by p38 and NF-kappaB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Feedback, Physiological; Humans; Imidazoles; Melanoma; Membrane Potential, Mitochondrial; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Protein Kinase Inhibitors; Pyridines; Pyrrolidines; Quinazolines; Reactive Oxygen Species; Signal Transduction; Thiocarbamates; Time Factors; Tumor Suppressor Protein p53 | 2008 |
Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells.
Topics: Acridine Orange; Apoptosis; Autophagy; bcl-X Protein; Cadaverine; Cell Nucleus; Cell Survival; HeLa Cells; Humans; Mitochondria; Necrosis; Nitric Oxide; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Reactive Oxygen Species | 2008 |
Enhancement of apoptosis of human hepatocellular carcinoma SMMC-7721 cells through synergy of berberine and evodiamine.
Topics: Apoptosis; Berberine; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Drug Synergism; Humans; Liver Neoplasms; Phytotherapy; Plant Extracts; Quinazolines; Tumor Necrosis Factor-alpha | 2008 |
The permeability and the efflux of alkaloids of the Evodiae fructus in the Caco-2 model.
Topics: Alkaloids; Biological Transport, Active; Caco-2 Cells; Chromatography, High Pressure Liquid; Evodia; Humans; Indole Alkaloids; Intestinal Absorption; Permeability; Plant Extracts; Quinazolines | 2009 |
Immunoregulatory effect of evodiamine in mice of various germlines.
Topics: Adjuvants, Immunologic; Animals; Cyclin-Dependent Kinase 2; Drugs, Chinese Herbal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Quinazolines; RNA, Messenger; Species Specificity; Spleen; Thymus Gland | 2008 |
Intragastric administration of evodiamine suppresses NPY and AgRP gene expression in the hypothalamus and decreases food intake in rats.
Topics: Agouti-Related Protein; Animals; Appetite Regulation; Arcuate Nucleus of Hypothalamus; Body Weight; Dose-Response Relationship, Drug; Down-Regulation; Feeding Behavior; Gene Expression Regulation; Hypothalamus; Leptin; Male; Neuropeptide Y; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2009 |
Evodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1alpha accumulation in RAW264.7.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Camptothecin; Cell Hypoxia; Cell Line; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; Pyrrolidines; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; Thiocarbamates | 2009 |
Evodiamine and rutaecarpine inhibit migration by LIGHT via suppression of NADPH oxidase activation.
Topics: Cell Line; Cell Movement; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Humans; Immunoblotting; Indole Alkaloids; Intercellular Adhesion Molecule-1; Monocytes; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Plant Extracts; Protein Serine-Threonine Kinases; Quinazolines; Reactive Oxygen Species; Receptors, CCR2; Tumor Necrosis Factor Ligand Superfamily Member 14 | 2009 |
Evodiamine stabilizes topoisomerase I-DNA cleavable complex to inhibit topoisomerase I activity.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; DNA Topoisomerases, Type I; DNA, Superhelical; Enzyme Stability; Female; Humans; Macromolecular Substances; Molecular Structure; Plant Extracts; Quinazolines; Topoisomerase I Inhibitors | 2009 |
Antiproliferation and apoptosis induced by evodiamine in human colorectal carcinoma cells (COLO-205).
Topics: Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma; Caspase 3; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Evodia; G2 Phase; Humans; Membrane Potentials; Mitochondria; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2009 |
Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats.
Topics: 3-Hydroxysteroid Dehydrogenases; 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Cholesterol Side-Chain Cleavage Enzyme; Colforsin; Corticosterone; Cyclic AMP; Desoxycorticosterone; Drugs, Chinese Herbal; Evodia; Hydroxycholesterols; Indole Alkaloids; Male; Phosphoproteins; Plant Extracts; Pregnenolone; Progesterone; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasodilator Agents; Zona Fasciculata; Zona Reticularis | 2009 |
[Study on vitro release and transdermal behaviors of Yulian cataplasm].
Topics: Animals; Berberine; Berberine Alkaloids; Drugs, Chinese Herbal; Indole Alkaloids; Mice; Plant Extracts; Quinazolines; Skin; Skin Absorption | 2009 |
Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation.
Topics: Adipocytes; Adipose Tissue, White; Anti-Obesity Agents; Berberine; Cell Differentiation; Cell Line; GATA2 Transcription Factor; GATA3 Transcription Factor; Gene Expression Regulation; Humans; Plant Extracts; Quinazolines; RNA, Messenger; Up-Regulation | 2010 |
Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.
Topics: 3T3-L1 Cells; Adipogenesis; Animals; Blotting, Western; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Mice; Mice, Knockout; Phosphorylation; Plant Extracts; Protein Kinase C-alpha; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; TRPV Cation Channels; Tyrphostins | 2009 |
Inhibitory effect of evodiamine alone and in combination with rosiglitazone on in vitro adipocyte differentiation and in vivo obesity related to diabetes.
Topics: Adipocytes; Adiponectin; Adipose Tissue; Animals; Blood Glucose; Cell Differentiation; Cell Line; Dietary Fats; Drug Therapy, Combination; Hypoglycemic Agents; Insulin; Liver; Mice; Mice, Inbred C57BL; Obesity; Plant Extracts; Quinazolines; Rosiglitazone; Thiazolidinediones; Weight Gain | 2010 |
Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Biotransformation; Blotting, Western; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Coloring Agents; Extracellular Signal-Regulated MAP Kinases; Fas Ligand Protein; Humans; Melanoma, Experimental; NF-kappa B; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Plant Extracts; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Tetrazolium Salts; Thiazoles; Ubiquitin | 2010 |
[Assay of evodin, evodiamine and rutaecarpine in Fructus Evodiae by QAMS].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Evodia; Furans; Heterocyclic Compounds, 4 or More Rings; Indole Alkaloids; Plant Extracts; Quinazolines | 2009 |
[Determination of evodiamine and rutaecarpine of compound Wuzhuyu cataplasm in plasma by SPE-HPLC: application to its pharmacokinetics].
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Indole Alkaloids; Male; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Solid Phase Extraction | 2009 |
Protein tyrosine kinase pathway-derived ROS/NO productions contribute to G2/M cell cycle arrest in evodiamine-treated human cervix carcinoma HeLa cells.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Antioxidants; Female; G2 Phase; Genistein; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Metaphase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidation-Reduction; Plant Extracts; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Reactive Oxygen Species; Signal Transduction | 2010 |
Anti-proliferative effects of evodiamine on human thyroid cancer cell line ARO.
Topics: Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Evodia; G2 Phase; Humans; In Situ Nick-End Labeling; Indole Alkaloids; Plant Extracts; Poly(ADP-ribose) Polymerases; Quinazolines; Thyroid Neoplasms; Time Factors | 2010 |
Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors.
Topics: Camptothecin; Comet Assay; DNA; DNA Damage; DNA Topoisomerases, Type I; Drug Evaluation, Preclinical; Enzyme Inhibitors; Enzymes, Immobilized; Humans; In Vitro Techniques; Kinetics; Macromolecular Substances; Models, Molecular; Plant Extracts; Quinazolines; Recombinant Proteins; Surface Plasmon Resonance; Topoisomerase I Inhibitors | 2010 |
Evodiamine induces caspase-dependent apoptosis and S phase arrest in human colon lovo cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Endodeoxyribonucleases; Female; Humans; Mice; Mice, Nude; Plant Extracts; Quinazolines; S Phase; Signal Transduction | 2010 |
A new quinolone and other constituents from the fruits of Tetradium ruticarpum: effects on neutrophil pro-inflammatory responses.
Topics: Anti-Inflammatory Agents; Evodia; Fruit; Humans; Indole Alkaloids; Molecular Structure; Neutrophils; Pancreatic Elastase; Plant Extracts; Quinazolines; Quinolines; Quinolones; Superoxides | 2010 |
Evodiamine as a novel antagonist of aryl hydrocarbon receptor.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Cytochrome P-450 CYP1A1; Gene Expression; Humans; Models, Molecular; Plant Extracts; Protein Biosynthesis; Protein Conformation; Quinazolines; Rats; Receptors, Aryl Hydrocarbon | 2010 |
Selection of evodiamine as a novel topoisomerase I inhibitor by structure-based virtual screening and hit optimization of evodiamine derivatives as antitumor agents.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Plant Extracts; Protein Binding; Quinazolines; Structure-Activity Relationship; Topoisomerase I Inhibitors | 2010 |
Optimization of extraction of evodiamine and rutaecarpine from fruit of Evodia rutaecarpa using modified supercritical CO(2).
Topics: Algorithms; Analysis of Variance; Carbon Dioxide; Chemical Fractionation; Chromatography, High Pressure Liquid; Evodia; Fruit; Indole Alkaloids; Methanol; Plant Extracts; Pressure; Quinazolines; Temperature; Time Factors | 2010 |
Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator protein 1 transactivation and cell transformation in human hepatocytes.
Topics: Antineoplastic Agents, Phytogenic; Cell Line; Cell Transformation, Neoplastic; Evodia; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Humans; Phosphorylation; Plant Extracts; Quinazolines; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Transfection | 2011 |
Evodiamine improves congnitive abilities in SAMP8 and APP(swe)/PS1(ΔE9) transgenic mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cognition; Disease Models, Animal; Maze Learning; Memory; Mice; Mice, Transgenic; Presenilin-1; Quinazolines; Random Allocation | 2011 |
Acid sphingomyelinase contributes to evodiamine-induced apoptosis in human gastric cancer SGC-7901 cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspases; Cell Line, Tumor; Ceramides; Chromatography, High Pressure Liquid; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Plant Extracts; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Stomach Neoplasms; Up-Regulation | 2011 |
Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cells.
Topics: Antineoplastic Agents, Phytogenic; Berberine; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Coptis; Drugs, Chinese Herbal; Evodia; Hep G2 Cells; Humans; Liver Neoplasms; NF-kappa B; Plant Extracts; Quinazolines; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2011 |
Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Capsaicin; Cattle; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; RNA Interference; Signal Transduction; Time Factors; Transfection; TRPV Cation Channels | 2011 |
[Optimization of a HPLC determination method for Evodia rutaecarpa].
Topics: Chromatography, High Pressure Liquid; Evodia; Indole Alkaloids; Limonins; Plant Extracts; Quinazolines | 2011 |
Berberine and evodiamine influence serotonin transporter (5-HTT) expression via the 5-HTT-linked polymorphic region.
Topics: Alleles; Animals; Berberine; Cell Line; Gene Expression; Plant Extracts; Polymorphism, Genetic; Promoter Regions, Genetic; Quinazolines; Rats; Serotonergic Neurons; Serotonin Plasma Membrane Transport Proteins | 2012 |
[Determination of evodiamine and rutacarpine in zhuyu hewei zhitong capsules by HPLC].
Topics: Alkaloids; Capsules; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Linear Models; Quality Control; Quinazolines; Reproducibility of Results | 2011 |
Induction of apoptosis by evodiamine involves both activation of mitotic arrest and mitotic slippage.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cyclin B1; Cyclin E; G2 Phase Cell Cycle Checkpoints; Gene Expression; Humans; Mitosis; Quinazolines | 2011 |
Enhanced transdermal delivery of evodiamine and rutaecarpine using microemulsion.
Topics: Administration, Cutaneous; Animals; Emulsions; Indole Alkaloids; Male; Microdialysis; Microscopy, Electron, Transmission; Pharmaceutical Vehicles; Quinazolines; Rats; Rats, Sprague-Dawley; Skin Absorption | 2011 |
Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Benzylisoquinolines; Cells, Cultured; Down-Regulation; Drugs, Chinese Herbal; E-Selectin; Endothelin-1; Endothelium, Vascular; Evodia; Humans; Interleukin-1alpha; Lipopolysaccharides; Morphinans; Proline; Pyrazines; Quinazolines; Quinolizines; Swine; Thromboxane B2 | 2012 |
Pharmacokinetic comparisons of rutaecarpine and evodiamine after oral administration of Wu-Chu-Yu extracts with different purities to rats.
Topics: Administration, Oral; Alkaloids; Animals; Biological Availability; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Drugs, Chinese Herbal; Evodia; Indole Alkaloids; Intestinal Absorption; Male; Plant Extracts; Quinazolines; Quinolines; Rats; Rats, Sprague-Dawley; Reference Standards | 2012 |
Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Deoxycytidine; Gemcitabine; Humans; Mice; NF-kappa B; Oncogene Protein v-akt; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Signal Transduction | 2012 |
Simultaneous determination of evodiamine and rutecarpine in rabbit plasma by LC-ESI-MS and its application to pharmacokinetics.
Topics: Animals; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Half-Life; Indicators and Reagents; Indole Alkaloids; Injections, Intravenous; Male; Quinazolines; Rabbits; Reference Standards; Reproducibility of Results; Solutions; Spectrometry, Mass, Electrospray Ionization | 2011 |
[Synthesis, physicochemical and pharmacological properties of pentacyclic alkaloid-analogues].
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Survival; Drugs, Chinese Herbal; Evodia; HeLa Cells; Humans; Indole Alkaloids; Piroxicam; Plant Extracts; Quinazolines; Therapeutic Equivalency | 2011 |
Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Beclin-1; Cell Cycle; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Stomach Neoplasms | 2012 |
[Studies on pharmacokinetics of evodiamine and rutaecarpine in rats plasma after oral administration extracts of euodiae fructus].
Topics: Administration, Oral; Animals; Evodia; Indole Alkaloids; Male; Plant Extracts; Quinazolines; Rats; Rats, Wistar | 2011 |
Simultaneous determination and pharmacokinetic analysis of seven alkaloids and two flavonoids from rat plasma by HPLC-DAD after oral administration of Wuzhuyu decoction.
Topics: Administration, Oral; Alkaloids; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Indole Alkaloids; Male; Molecular Structure; Quinazolines; Rats | 2012 |
Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Topoisomerases; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Evodia; Fruit; Humans; Inhibitory Concentration 50; Leukemia; Phytotherapy; Quinazolines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topoisomerase Inhibitors | 2012 |
Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase.
Topics: AMP-Activated Protein Kinases; Animals; Aorta; Blood Vessels; Blotting, Western; Cattle; Cells, Cultured; Collagen; Drug Combinations; Endothelial Cells; Enzyme Activation; Hindlimb; Injections, Intraperitoneal; Laminin; Male; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Binding; Proteoglycans; Quinazolines; TRPV Cation Channels | 2012 |
Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo.
Topics: Administration, Cutaneous; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Evodia; Female; Indole Alkaloids; Male; Mice; Oleic Acid; Pain; Plant Extracts; Quinazolines; Sesquiterpenes; Skin; Swine | 2012 |
In vitro cellular uptake of evodiamine and rutaecarpine using a microemulsion.
Topics: Animals; Emulsions; Fibroblasts; Indole Alkaloids; Mice; Microscopy, Confocal; Nanoparticles; NIH 3T3 Cells; Particle Size; Quinazolines; Rhodamines | 2012 |
Investigation of the in vitro metabolism of evodiamine: characterization of metabolites and involved cytochrome p450 isoforms.
Topics: Alkaloids; Animals; Cytochrome P-450 Enzyme System; Evodia; Humans; Isoenzymes; Male; Microsomes, Liver; Quinazolines; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2013 |
New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations.
Topics: Antineoplastic Agents, Phytogenic; Biological Products; Cell Line, Tumor; Drug Screening Assays, Antitumor; Evodia; Humans; Quinazolines; Structure-Activity Relationship | 2012 |
A drug screening method based on the autophagy pathway and studies of the mechanism of evodiamine against influenza A virus.
Topics: Adenylate Kinase; Animals; Antiviral Agents; Autophagy; Carrier Proteins; Cell Line; Cytokines; Drug Evaluation, Preclinical; Gene Expression; Humans; Influenza A virus; Microtubule-Associated Proteins; Protein Binding; Protein Multimerization; Quinazolines; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Virus Replication | 2012 |
Binding mode pediction of evodiamine within vanilloid receptor TRPV1.
Topics: Animals; Binding Sites; Humans; Molecular Docking Simulation; Protein Binding; Quinazolines; Rabbits; Rats; TRPV Cation Channels | 2012 |
Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis.
Topics: Animals; Apolipoproteins E; Blotting, Western; Coronary Artery Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fatty Liver; Hyperlipidemias; Male; Mice; Mice, Knockout; Quinazolines; TRPV Cation Channels | 2013 |
Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Interleukin-6; Janus Kinase 2; Liver Neoplasms; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Quinazolines; RNA Interference; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Tyrphostins; Xenograft Model Antitumor Assays | 2013 |
Evodiamine activates autophagy as a cytoprotective response in murine Lewis lung carcinoma cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Carcinoma, Lewis Lung; Caspases; Cell Line, Tumor; Cell Proliferation; Gene Expression; Mice; Microtubule-Associated Proteins; Quinazolines; Up-Regulation | 2013 |
Topoisomerase I inhibitor evodiamine acts as an antibacterial agent against drug-resistant Klebsiella pneumoniae.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Evodia; Klebsiella pneumoniae; Microbial Sensitivity Tests; Plant Extracts; Quinazolines; Topoisomerase I Inhibitors | 2013 |
Differential expression of lipid metabolism genes in the liver and adipose tissue of mice treated with evodiamine.
Topics: Adipose Tissue; Animals; Body Temperature; Fatty Acid Synthases; Gene Expression Profiling; Gene Expression Regulation; Lipid Metabolism; Lipolysis; Liver; Male; Mice; PPAR gamma; Quinazolines; RNA, Messenger; Sterol Regulatory Element Binding Protein 1 | 2013 |
Simultaneous determination of six bioactive compounds in Evodiae Fructus by high-performance liquid chromatography with diode array detection.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Evodia; Fruit; Indole Alkaloids; Limonins; Plant Extracts; Quinazolines; Reproducibility of Results; Triterpenes | 2014 |
Simultaneous determination of evodiamine and evodine in Beagle dog plasma using liquid chromatography tandem mass spectrometry.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Dogs; Furans; Heterocyclic Compounds, 4 or More Rings; Quinazolines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Evodiamine induces apoptosis and inhibits metastasis in MDA‑MB-231 human breast cancer cells in vitro and in vivo.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Female; G1 Phase; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Receptors, Urokinase Plasminogen Activator; Resting Phase, Cell Cycle; Urokinase-Type Plasminogen Activator | 2013 |
A superparamagnetic Fe3O4-loaded polymeric nanocarrier for targeted delivery of evodiamine with enhanced antitumor efficacy.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Magnetite Nanoparticles; Nanostructures; Particle Size; Polymers; Quinazolines; Structure-Activity Relationship; Surface Properties | 2013 |
Synergistic anticancer effects of polyphyllin I and evodiamine on freshly-removed human gastric tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Confidence Intervals; Diosgenin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; Irinotecan; Male; Middle Aged; Neoplasm Proteins; Platinum; Quinazolines; RNA, Messenger; Stomach Neoplasms | 2013 |
Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Calcium; Cell Line, Tumor; Evodia; Glioblastoma; Humans; MAP Kinase Signaling System; Models, Biological; Quinazolines | 2013 |
Anti-Proliferative Effects of Evodiamine on Human Breast Cancer Cells.
Topics: Antineoplastic Agents; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 7; Cell Proliferation; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Quinazolines | 2013 |
Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels.
Topics: Animals; Calcium Signaling; Dose-Response Relationship, Drug; Drug Design; Drugs, Chinese Herbal; HEK293 Cells; Humans; Isomerism; Membrane Transport Modulators; Molecular Structure; Quinazolines; Rats; Structure-Activity Relationship; Transfection; TRPV Cation Channels | 2014 |
Berberine counteracts enhanced IL-8 expression of AGS cells induced by evodiamine.
Topics: Antineoplastic Agents, Phytogenic; Berberine; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Chemokines; Chemokines, CXC; Chromones; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-8; Morpholines; Pyridines; Quinazolines; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured | 2013 |
Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins.
Topics: Alkaloids; Binding Sites; Carbolines; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Enzyme Activation; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Protein Structure, Tertiary; Quinazolines; Sirtuins; Topoisomerase I Inhibitors | 2013 |
Design, synthesis and evaluation of N13-substituted evodiamine derivatives against human cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; MCF-7 Cells; Models, Molecular; Molecular Conformation; Quinazolines | 2013 |
Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Evodia; Female; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mice, Obese; Phosphorylation; Quinazolines; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Growth inhibition and induction of apoptosis in SGC‑7901 human gastric cancer cells by evodiamine.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Shape; Humans; Quinazolines; Stomach Neoplasms | 2014 |
Evodiamine and rutaecarpine alkaloids as highly selective transient receptor potential vanilloid 1 agonists.
Topics: Animals; Humans; Indole Alkaloids; Models, Molecular; Protein Conformation; Quinazolines; Rabbits; Rats; Substrate Specificity; TRPV Cation Channels | 2014 |
New limonoids from Coptidis Rhizoma-Euodiae Fructus couple.
Topics: Antineoplastic Agents, Phytogenic; Caco-2 Cells; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Evodia; Fruit; Humans; Indole Alkaloids; Limonins; Molecular Structure; Quinazolines; Rhizome | 2014 |
Evodiamine induces apoptosis and enhances TRAIL-induced apoptosis in human bladder cancer cells through mTOR/S6K1-mediated downregulation of Mcl-1.
Topics: Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Down-Regulation; Evodia; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Quinazolines; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; RNA, Messenger; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; TOR Serine-Threonine Kinases; Urinary Bladder Neoplasms | 2014 |
Evodiamine might inhibit TGF-beta1-induced epithelial-mesenchymal transition in NRK52E cells via Smad and PPAR-gamma pathway.
Topics: Actins; Animals; Cadherins; Cell Line; Epithelial-Mesenchymal Transition; PPAR gamma; Quinazolines; Rats; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2014 |
Long-term effects of evodiamine on expressions of lipogenesis and lipolysis genes in mouse adipose and liver tissues.
Topics: Adipose Tissue; Animals; Body Temperature; Diet; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression Regulation; Lipogenesis; Lipolysis; Liver; Male; Mice; Quinazolines; Weight Gain | 2014 |
Metabolic activation of the indoloquinazoline alkaloids evodiamine and rutaecarpine by human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.
Topics: Activation, Metabolic; Cytochrome P-450 CYP3A; Humans; Hydrogenation; Indole Alkaloids; Microsomes, Liver; Plant Extracts; Quinazolines | 2014 |
Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.
Topics: Antioxidants; Butyrylcholinesterase; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Quinazolines; Structure-Activity Relationship | 2014 |
Evodiamine synergizes with doxorubicin in the treatment of chemoresistant human breast cancer without inhibiting P-glycoprotein.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Caspases; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Drugs, Chinese Herbal; Female; Gene Expression Regulation, Neoplastic; Humans; L-Lactate Dehydrogenase; MCF-7 Cells; Medicine, Chinese Traditional; Poly(ADP-ribose) Polymerases; Quinazolines; Signal Transduction | 2014 |
Preparation, characterization, and anticancer efficacy of evodiamine-loaded PLGA nanoparticles.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Female; Humans; Lactic Acid; MCF-7 Cells; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Quinazolines | 2016 |
Pretreatment by evodiamine is neuroprotective in cerebral ischemia: up-regulated pAkt, pGSK3β, down-regulated NF-κB expression, and ameliorated BBB permeability.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Capillary Permeability; Down-Regulation; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Neuroprotective Agents; NF-kappa B; Plant Extracts; Proto-Oncogene Proteins c-akt; Quinazolines; Treatment Outcome; Up-Regulation | 2014 |
Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: a structure-activity study of evodiamine.
Topics: Alkylation; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; HT29 Cells; Humans; M Phase Cell Cycle Checkpoints; MAP Kinase Signaling System; Mice; NIH 3T3 Cells; Quinazolines; Structure-Activity Relationship | 2014 |
Supermolecular evodiamine loaded water-in-oil nanoemulsions: enhanced physicochemical and biological characteristics.
Topics: Biological Availability; Emulsions; Gastrointestinal Tract; Kinetics; Oils; Permeability; Quinazolines; Water | 2014 |
Evodiamine activates AMPK and promotes adiponectin multimerization in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; AMP-Activated Protein Kinases; Animals; Calcium; Evodia; Insulin Resistance; Mice; Molecular Structure; Molecular Weight; Phosphatidylinositol 3-Kinases; Quinazolines; Signal Transduction | 2014 |
[Inhibitory effect of norcantharidin combined with evodiamine on the growth of human hepatic carcinoma cell line HepG2 in vitro].
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Hepatoblastoma; Humans; Liver Neoplasms; Proto-Oncogene Proteins c-bcl-2; Quinazolines | 2014 |
Characteristics of evodiamine-exerted stimulatory effects on rat jejunal contractility.
Topics: Animals; Calcium; Calcium Channel Blockers; Gastrointestinal Motility; Jejunum; Molecular Structure; Muscle Contraction; Myosins; Nifedipine; Phosphorylation; Quinazolines; Rats; Tetrodotoxin | 2015 |
[Fast analysis of indole alkaloids from Evodiae fructus by supercritical fluid chromatography].
Topics: Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Evodia; Indole Alkaloids; Quinazolines | 2014 |
Role of the conformational flexibility of evodiamine in its binding to protein hosts: a comparative spectroscopic and molecular modeling evaluation with rutaecarpine.
Topics: Binding Sites; Circular Dichroism; Humans; Indole Alkaloids; Models, Molecular; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Quinazolines; Serum Albumin; Spectrophotometry, Ultraviolet; Stereoisomerism | 2014 |
Improved absorption and in vivo kinetic characteristics of nanoemulsions containing evodiamine-phospholipid nanocomplex.
Topics: Administration, Oral; Animals; Biological Availability; Emulsions; Gastric Mucosa; Intestinal Mucosa; Intestines; Male; Nanostructures; Phospholipids; Quinazolines; Rats; Rats, Sprague-Dawley; Stomach | 2014 |
Evodiamine sensitizes U87 glioblastoma cells to TRAIL via the death receptor pathway.
Topics: Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Activation; Glioblastoma; Humans; Quinazolines; Receptors, Death Domain; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand | 2015 |
Evodiamine induces G2/M arrest and apoptosis via mitochondrial and endoplasmic reticulum pathways in H446 and H1688 human small-cell lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum; Humans; Lung Neoplasms; M Phase Cell Cycle Checkpoints; Mitochondria; Quinazolines; Small Cell Lung Carcinoma | 2014 |
Toxicity of Evodiae fructus on rat liver mitochondria: the role of oxidative stress and mitochondrial permeability transition.
Topics: Adenosine Triphosphate; Animals; Cytochromes c; Evodia; Furans; Glutathione; Heterocyclic Compounds, 4 or More Rings; Indole Alkaloids; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria, Liver; Oxidative Stress; Permeability; Plant Extracts; Quinazolines; Rats; Superoxide Dismutase | 2014 |
Identification of evodiamine as the bioactive compound in evodia (Evodia rutaecarpa Benth.) fruit extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ).
Topics: Animals; CHO Cells; Chromans; Chromatography, High Pressure Liquid; Cricetulus; Evodia; Fruit; Hep G2 Cells; Humans; Indole Alkaloids; Mass Spectrometry; Molecular Structure; Plant Extracts; PPAR gamma; Quinazolines; Thiazolidinediones; Troglitazone | 2015 |
Antidepressant-like effect of evodiamine on chronic unpredictable mild stress rats.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chronic Disease; Corticosterone; Hippocampus; Male; Norepinephrine; Phosphorylation; Quinazolines; Rats, Sprague-Dawley; Receptor, trkB; RNA, Messenger; Serotonin; Stress, Psychological | 2015 |
Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells – a critical role of Cdk1 in mitotic entry.
Topics: Antineoplastic Agents; Apoptosis; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line, Tumor; Cyclin B1; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitosis; Nocodazole; Paclitaxel; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Quinazolines; RNA, Small Interfering; Signal Transduction; Tubulin Modulators; Vincristine | 2015 |
Apoptosis of human non-small-cell lung cancer A549 cells triggered by evodiamine through MTDH-dependent signaling pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Adhesion Molecules; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; RNA-Binding Proteins; RNA, Small Interfering; Signal Transduction | 2015 |
In Vitro Assessment of the Anticancer Potential of Evodiamine in Human Oral Cancer Cell Lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Humans; Mitochondria; Morpholines; Mouth Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Plant Extracts; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-akt; Quinazolines | 2015 |
Inhibition of hedgehog signalling attenuates UVB-induced skin photoageing.
Topics: Aging; Anilides; Animals; Cell Line; Cyclooxygenase 2; Cytokines; Drug Evaluation, Preclinical; Flavonoids; Gene Expression Regulation; Hedgehog Proteins; Humans; Inflammation; MAP Kinase Signaling System; Mice; Pyridines; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Skin Aging; Tissue Inhibitor of Metalloproteinase-1; Ultraviolet Rays | 2015 |
Evodiamine inhibits the proliferation of human osteosarcoma cells by blocking PI3K/Akt signaling.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Osteosarcoma; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction | 2015 |
Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels.
Topics: Alkaloids; Analgesics; Animals; Calcium; Calcium Channels; Capsaicin; Dose-Response Relationship, Drug; Evodia; Ganglia, Spinal; HEK293 Cells; Hot Temperature; Humans; Hyperalgesia; Male; Medicine, Chinese Traditional; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Plant Extracts; Quinazolines; Quinolines; Rats; Rats, Sprague-Dawley; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2016 |
Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Catalase; Cell Line; Dinoprostone; Ethanol; Female; Gastric Mucosa; Glutathione; Humans; Interleukin-6; Malondialdehyde; Mice, Inbred BALB C; NF-kappa B; Peroxidase; Quinazolines; Stomach; Stomach Ulcer; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2015 |
Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biological Products; Cell Cycle; Cell Line, Tumor; Drug Design; Drug Discovery; Drug Screening Assays, Antitumor; Evodia; Humans; Models, Molecular; Quinazolines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tubulin Modulators | 2015 |
Rutaecarpine and evodiamine selected as β1-AR inhibitor candidates using β1-AR/CMC-offline-UPLC/MS prevent cardiac ischemia-reperfusion injury via energy modulation.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Cell Membrane; Cell Survival; CHO Cells; Chromatography, High Pressure Liquid; Cricetulus; Energy Metabolism; Evodia; Indole Alkaloids; Male; Mass Spectrometry; Myocardial Reperfusion Injury; Quinazolines; Rats, Wistar; Receptors, Adrenergic, beta-1 | 2015 |
Beneficial effects of evodiamine on P2X(4)-mediated inflammatory injury of human umbilical vein endothelial cells due to high glucose.
Topics: Drugs, Chinese Herbal; Endothelium, Vascular; Evodia; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; NF-kappa B; Nitric Oxide; Quinazolines; Reactive Oxygen Species; Receptors, Purinergic P2X4; Receptors, Tumor Necrosis Factor; Umbilical Veins; Up-Regulation | 2015 |
[Effects of evodiamine, a major alkaloid of Goshuyu (Evodia Fruits), on TRPV1].
Topics: Body Temperature; Evodia; Fruit; Humans; Obesity; Pain Management; Quinazolines; TRPV Cation Channels | 2015 |
Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor.
Topics: Alkaloids; Animals; Constitutive Androstane Receptor; Dose-Response Relationship, Drug; Evodia; Forkhead Box Protein O1; Gene Expression Regulation; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Hypoglycemic Agents; Indole Alkaloids; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoenolpyruvate Carboxykinase (ATP); Primary Cell Culture; Quinazolines; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2016 |
Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; beta Catenin; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Epithelial-Mesenchymal Transition; Flow Cytometry; Humans; Kruppel-Like Factor 4; Molecular Structure; Neoplastic Stem Cells; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Quinazolines; Snail Family Transcription Factors; Stomach Neoplasms; Transcription Factors; Twist-Related Protein 1; Wnt Signaling Pathway | 2015 |
Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1α downregulation.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor I; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction | 2015 |
Evodiamine inhibits the migration and invasion of nasopharyngeal carcinoma cells in vitro via repressing MMP-2 expression.
Topics: Blotting, Western; Carcinoma; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Structure; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction | 2015 |
Anti-proliferative activity and cell cycle arrest induced by evodiamine on paclitaxel-sensitive and -resistant human ovarian cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Ovarian Epithelial; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Mice; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Paclitaxel; Quinazolines | 2015 |
Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Janus Kinase 2; Plant Extracts; Protein Kinase Inhibitors; Quinazolines; Signal Transduction | 2015 |
Effects of Evodiamine on the Pharmacokinetics of Dapoxetine and Its Metabolite Desmethyl Dapoxetine in Rats.
Topics: Animals; Area Under Curve; Benzylamines; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Half-Life; Male; Naphthalenes; Plant Extracts; Quinazolines; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2016 |
Evodiamine Suppresses ABCG2 Mediated Drug Resistance by Inhibiting p50/p65 NF-κB Pathway in Colorectal Cancer.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; Neoplasm Proteins; NF-kappa B; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2016 |
Evodiamine inhibits the proliferation of leukemia cell line K562 by regulating peroxisome proliferators-activated receptor gamma (PPARγ) pathway.
Topics: Anilides; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation, Neoplastic; Humans; K562 Cells; Leukemia; PPAR gamma; Quinazolines | 2016 |
Evodiamine Attenuates PDGF-BB-Induced Migration of Rat Vascular Smooth Muscle Cells through Activating PPARγ.
Topics: Animals; Becaplermin; Cell Movement; Cells, Cultured; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Proto-Oncogene Proteins c-sis; Quinazolines; Rats; Rats, Sprague-Dawley; Wound Healing | 2015 |
Optimization of combinations of ginsenoside-Rg1, ginsenoside-Rb1, evodiamine and rutaecarpine for effective therapy of mouse migraine.
Topics: Animals; Dopamine; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Indole Alkaloids; Medicine, Chinese Traditional; Mice, Inbred ICR; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Phytotherapy; Quinazolines; Serotonin | 2016 |
Evodiamine selectively targets cancer stem-like cells through the p53-p21-Rb pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Humans; MCF-7 Cells; Neoplastic Stem Cells; Quinazolines; Retinoblastoma Protein; Signal Transduction; Treatment Outcome; Tumor Suppressor Protein p53 | 2016 |
Evodiamine induces apoptosis and enhances apoptotic effects of erlotinib in wild-type EGFR NSCLC cells via S6K1-mediated Mcl-1 inhibition.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Quinazolines; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases | 2016 |
[Effect of evodiamine in inducing apoptosis of gastric cancer SGC-7901 cells through mTOR signal pathway].
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Quinazolines; Signal Transduction; Stomach Neoplasms; TOR Serine-Threonine Kinases | 2015 |
Effect of Evodiamine on CYP Enzymes in Rats by a Cocktail Method.
Topics: Administration, Oral; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Herb-Drug Interactions; Liver; Male; Metoprolol; Midazolam; Omeprazole; Phenacetin; Quinazolines; Rats, Sprague-Dawley; Tolbutamide | 2016 |
Evodiamine from Evodia rutaecarpa induces apoptosis via activation of JNK and PERK in human ovarian cancer cells.
Topics: Adenine; Anthracenes; Apoptosis; Caspase 3; Cell Line, Tumor; eIF-2 Kinase; Evodia; Female; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Ovarian Neoplasms; Poly(ADP-ribose) Polymerases; Quinazolines; Signal Transduction; Structure-Activity Relationship | 2016 |
[A preliminary study of pharmacokinetics of evodiamine hydroxypropyl-β-cyclodextrin inclusion complex].
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Biological Availability; Chromatography, High Pressure Liquid; Quinazolines; Rats; Rats, Sprague-Dawley; Solubility | 2016 |
Partial Activation and Inhibition of TRPV1 Channels by Evodiamine and Rutaecarpine, Two Major Components of the Fruits of Evodia rutaecarpa.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Evodia; Fruit; HEK293 Cells; Humans; Indole Alkaloids; Molecular Structure; Quinazolines; TRPV Cation Channels | 2016 |
Evodiamine sensitizes BGC-823 gastric cancer cells to radiotherapy in vitro and in vivo.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Immunohistochemistry; Male; Mice; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Radiation-Sensitizing Agents; Receptor, ErbB-2; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Antiproliferative activity and apoptosis inducing effects of nitric oxide donating derivatives of evodiamine.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Inhibitory Concentration 50; Molecular Structure; Nitric Oxide; Quinazolines | 2016 |
Inhibition of five natural products from Chinese herbs on the growth of Chattonella marina.
Topics: Alkaloids; Benzaldehydes; Biological Products; Catalase; Chlorophyll; Curcumin; Drugs, Chinese Herbal; Harmful Algal Bloom; Indole Alkaloids; Malondialdehyde; Microalgae; Oxidation-Reduction; Oxidative Stress; Photosynthesis; Quinazolines; Stramenopiles; Superoxide Dismutase | 2016 |
[Evodiamine enhances the radiosensitivity of esophageal squamous cell cancer Eca-109 cells].
Topics: Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA-Activated Protein Kinase; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Esophageal Neoplasms; Humans; Ku Autoantigen; Nuclear Proteins; Plant Extracts; Quinazolines; Rad51 Recombinase; Radiation Tolerance; X-Rays | 2016 |
A novel alkaloid, evodiamine causes nuclear localization of cytochrome-c and induces apoptosis independent of p53 in human lung cancer cells.
Topics: A549 Cells; Alkaloids; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cytochromes c; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Nuclear Localization Signals; Quinazolines; Tissue Distribution; Treatment Outcome; Tumor Suppressor Protein p53 | 2016 |
Evodiamine exerts anti-tumor effects against hepatocellular carcinoma through inhibiting β-catenin-mediated angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; beta Catenin; Blotting, Western; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Movement; Cell Survival; Evodia; Hep G2 Cells; Humans; Immunohistochemistry; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Phytotherapy; Plant Extracts; Quinazolines; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2016 |
Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine Based on 3D Tumor Models.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Indole Alkaloids; Inhibitory Concentration 50; Molecular Structure; Plant Extracts; Quinazolines; Spectrum Analysis; Spheroids, Cellular; Tumor Cells, Cultured | 2016 |
[Evodiamine induces extrinsic and intrinsic apoptosis of ovarian cancer cells via the mitogen-activated protein kinase/phosphatidylinositol-3-kinase/protein kinase B signaling pathways].
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Drugs, Chinese Herbal; Evodia; Female; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines | 2016 |
Protein Kinase RNA-Like Endoplasmic Reticulum Kinase-Mediated Bcl-2 Protein Phosphorylation Contributes to Evodiamine-Induced Apoptosis of Human Renal Cell Carcinoma Cells.
Topics: Adenine; Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Renal Cell; Caspase 3; Cell Line, Tumor; eIF-2 Kinase; Gene Expression Regulation; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Kidney Neoplasms; Male; Membrane Potential, Mitochondrial; Mice, Nude; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Effect of evodiamine on the proliferation and apoptosis of A549 human lung cancer cells.
Topics: A549 Cells; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 8; Cell Cycle; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutathione; Hedgehog Proteins; Humans; Lung Neoplasms; Plant Extracts; Quinazolines; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Telomerase | 2016 |
Evodiamine inhibits PDGF‑BB‑induced proliferation of rat vascular smooth muscle cells through the suppression of cell cycle progression and oxidative stress.
Topics: Animals; Cell Cycle; Cell Proliferation; Cell Survival; Evodia; Gene Expression Regulation; Medicine, Chinese Traditional; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-sis; Quinazolines; Rats; Reactive Oxygen Species; Vascular Diseases | 2016 |
SN38 increases IL-8 expression through the MAPK pathways in HCT8 cells.
Topics: Berberine; Camptothecin; Cell Line, Tumor; Cell Survival; Fluorouracil; Humans; Interleukin-8; Irinotecan; Janus Kinase 2; MAP Kinase Signaling System; Phosphorylation; Quinazolines; Up-Regulation | 2017 |
Effect of evodiamine and berberine on the interaction between DNMTs and target microRNAs during malignant transformation of the colon by TGF-β1.
Topics: Animals; Animals, Newborn; Berberine; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation, Neoplastic; Immunoenzyme Techniques; MicroRNAs; Promoter Regions, Genetic; Quinazolines; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta1 | 2017 |
Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Evodia; Hep G2 Cells; Humans; Liver; Liver Neoplasms; Proto-Oncogene Proteins c-akt; Quinazolines | 2017 |
Exploration of anti-cancer effects and mechanisms of Zuo-Jin-Wan and its alkaloid components in vitro and in orthotopic HepG2 xenograft immunocompetent mice.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Berberine; Carcinoma, Hepatocellular; Coptis; Drugs, Chinese Herbal; Evodia; Female; Hep G2 Cells; Heterografts; Humans; Medicine, Chinese Traditional; Mice, Inbred ICR; Phytotherapy; Quinazolines | 2017 |
Evodiamine Induces Cell Growth Arrest, Apoptosis and Suppresses Tumorigenesis in Human Urothelial Cell Carcinoma Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogenesis; Carcinoma; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Fluorescein-5-isothiocyanate; Fluorouracil; Humans; Mutation; Plant Extracts; Quinazolines; Signal Transduction; Urinary Bladder Neoplasms; Urothelium | 2017 |
Evodiamine Inhibits Zymosan-Induced Inflammation In Vitro and In Vivo: Inactivation of NF-κB by Inhibiting IκBα Phosphorylation.
Topics: Cytokines; Humans; Inflammation; Intestinal Mucosa; Lung; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Quinazolines; Zymosan | 2017 |
Evodiamine Prevents Glioma Growth, Induces Glioblastoma Cell Apoptosis and Cell Cycle Arrest through JNK Activation.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blood-Brain Barrier; Cell Cycle Checkpoints; Cell Survival; Cell Transformation, Neoplastic; Evodia; Glioblastoma; Glioma; Humans; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Tumor Cells, Cultured | 2017 |
Co-delivery of evodiamine and rutaecarpine in a microemulsion-based hyaluronic acid hydrogel for enhanced analgesic effects on mouse pain models.
Topics: Analgesics; Animals; Dinoprostone; Drug Carriers; Emulsions; Guinea Pigs; Hyaluronic Acid; Hydrogels; Indole Alkaloids; Interleukin-6; Mice; Pain; Quinazolines; Skin Absorption; Tumor Necrosis Factor-alpha | 2017 |
Evaluation of the Cardiotoxicity of Evodiamine In Vitro and In Vivo.
Topics: Aldehydes; Animals; Animals, Newborn; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Evodia; Fruit; Heart Rate; Humans; L-Lactate Dehydrogenase; Myocytes, Cardiac; Oxidative Stress; Plant Extracts; Primary Cell Culture; Quinazolines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Toxicity Tests, Acute; Zebrafish | 2017 |
Evodiamine Exerts an Anti-Hepatocellular Carcinoma Activity through a WWOX-Dependent Pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Evodia; Gene Knockdown Techniques; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Quinazolines; WW Domain-Containing Oxidoreductase | 2017 |
Cytological Assessments and Transcriptome Profiling Demonstrate that Evodiamine Inhibits Growth and Induces Apoptosis in a Renal Carcinoma Cell Line.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Quinazolines; Signal Transduction; Transcriptome | 2017 |
Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity.
Topics: Antineoplastic Agents; Carbolines; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Mechlorethamine; Quinazolines; Quinazolinones; Structure-Activity Relationship | 2017 |
Combination of berberine and evodiamine inhibits intestinal cholesterol absorption in high fat diet induced hyperlipidemic rats.
Topics: Administration, Oral; Animals; Apolipoprotein B-48; Berberine; Body Weight; Cholesterol, LDL; Coptis; Diet, High-Fat; Drug Combinations; Evodia; Gene Expression Regulation; Hyperlipidemias; Hypolipidemic Agents; Intestinal Absorption; Lipid Metabolism; Liver; Male; Membrane Transport Proteins; Quinazolines; Rats; Rats, Sprague-Dawley; Sitosterols; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2; Triglycerides | 2017 |
Evodiamine promotes differentiation and inhibits proliferation of C2C12 muscle cells.
Topics: Animals; Cell Differentiation; Cell Line; Cell Proliferation; Mice; Muscle Cells; Muscle Development; Muscle Proteins; Quinazolines; RNA, Messenger; Wnt Signaling Pathway | 2018 |
Evodiamine induces apoptosis and promotes hepatocellular carcinoma cell death induced by vorinostat via downregulating HIF-1α under hypoxia.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Synergism; Humans; Hydroxamic Acids; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Quinazolines; Vorinostat | 2018 |
Structure-Activity Relationships of the Main Bioactive Constituents of
Topics: Alkaloids; Animals; Bile Acids and Salts; Cell Line, Tumor; Drugs, Chinese Herbal; Evodia; Genes, Reporter; Hep G2 Cells; Hepatocytes; Homeostasis; Humans; Indole Alkaloids; Liver; Male; Mice; Mice, Inbred C57BL; Quinazolines; Receptors, Aryl Hydrocarbon; RNA, Messenger; Structure-Activity Relationship; Up-Regulation | 2018 |
Pharmacological Basis for the Use of Evodiamine in Alzheimer's Disease: Antioxidation and Antiapoptosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Brain; Cell Line; Mice; Mice, Inbred BALB C; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Quinazolines; Reactive Oxygen Species | 2018 |
Improved delivery of natural alkaloids into lung cancer through woody oil-based emulsive nanosystems.
Topics: A549 Cells; Alkaloids; Animals; Antineoplastic Agents; Biological Availability; Brucea javanica; Cell Line, Tumor; Drug Delivery Systems; Drugs, Chinese Herbal; Emulsions; Excipients; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Nanoparticles; Plant Oils; Quinazolines; Rats; Rats, Sprague-Dawley; Solubility; Wool | 2018 |
Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux.
Topics: ATP Binding Cassette Transporter 1; Biological Transport; Cell Line; Cholesterol; HEK293 Cells; Humans; Macrophages; Quinazolines; Tandem Mass Spectrometry | 2018 |
Evodiamine inhibits gastrointestinal motility via CCK and CCK1 receptor in water-avoidence stress rat model.
Topics: Animals; Avoidance Learning; Biomarkers; Disease Models, Animal; Gastrointestinal Motility; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide; Stress, Psychological | 2018 |
Proteomic analysis of evodiamine-induced cytotoxicity in thyroid cancer cells.
Topics: Cell Line, Tumor; Cell Survival; Humans; Proteomics; Quinazolines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Two-Dimensional Difference Gel Electrophoresis | 2018 |
Evodiamine Induces Apoptosis, G2/M Cell Cycle Arrest, and Inhibition of Cell Migration and Invasion in Human Osteosarcoma Cells via Raf/MEK/ERK Signalling Pathway.
Topics: Apoptosis; Bone Neoplasms; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; MAP Kinase Signaling System; Neoplasm Invasiveness; Osteosarcoma; Proto-Oncogene Proteins c-raf; Quinazolines; Signal Transduction | 2018 |
Evodiamine alleviates severe pneumonia induced by methicillin-susceptible Staphylococcus aureus following cytomegalovirus reactivation through suppressing NF-κB and MAPKs.
Topics: Animals; Blotting, Western; Cell Line; Cytomegalovirus; Female; Humans; Interleukin-1beta; Interleukin-6; Methicillin; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; Pneumonia; Quinazolines; Signal Transduction; Staphylococcus aureus; Tumor Necrosis Factor-alpha | 2018 |
Evodiamine Induces Apoptosis in SMMC-7721 and HepG2 Cells by Suppressing NOD1 Signal Pathway.
Topics: Animals; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Nod1 Signaling Adaptor Protein; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2018 |
Evodiamine Suppresses Survival, Proliferation, Migration and Epithelial-Mesenchymal Transition of Thyroid Carcinoma Cells.
Topics: Androstadienes; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Synergism; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Thyroid Neoplasms; Wortmannin | 2018 |
A novel microemulsion-based isotonic perfusate modulated by Ringer's solution for improved microdialysis recovery of liposoluble substances.
Topics: Animals; Drug Carriers; Emulsions; Fibroblasts; Humans; Isotonic Solutions; Lipids; Male; Membranes, Artificial; Microdialysis; Nanoparticles; Oleic Acids; Particle Size; Perfusion; Polyethylene Glycols; Quinazolines; Rats, Sprague-Dawley; Ringer's Solution; Ruthenium; Skin Absorption; Solubility; Surface-Active Agents | 2018 |
A mediator of phosphorylated Smad2/3, evodiamine, in the reversion of TAF-induced EMT in normal colonic epithelial cells.
Topics: Apoptosis; Cancer-Associated Fibroblasts; Cell Movement; Cell Proliferation; Colon; Epithelial Cells; Epithelial-Mesenchymal Transition; Humans; Phosphorylation; Quinazolines; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Tumor Cells, Cultured | 2019 |
Thermo- and pH-responsive, Lipid-coated, Mesoporous Silica Nanoparticle-based Dual Drug Delivery System To Improve the Antitumor Effect of Hydrophobic Drugs.
Topics: Animals; Antineoplastic Agents; Berberine; Cell Line, Tumor; Cell Movement; Drug Carriers; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Mice; Nanoparticles; Quinazolines; Silicon Dioxide; Temperature; Xenograft Model Antitumor Assays | 2019 |
Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome.
Topics: Animals; Colitis; Dextran Sulfate; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Plant Extracts; Quinazolines | 2019 |
Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-
Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Humans; Indole Alkaloids; Lung Neoplasms; Molecular Structure; Pyrimidinones; Quinazolines; Structure-Activity Relationship | 2020 |
Induction of phosphatase shatterproof 2 by evodiamine suppresses the proliferation and invasion of human cholangiocarcinoma.
Topics: Animals; Antineoplastic Agents; Bile Duct Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholangiocarcinoma; Enzyme Induction; Humans; Interleukin-6; Mice; Neoplasm Invasiveness; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2019 |
Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cytokines; Disease Models, Animal; Ganglia, Spinal; Humans; Inflammation Mediators; Male; Membrane Potential, Mitochondrial; Mitochondria; Neuralgia; Oxidative Stress; Paclitaxel; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phytotherapy; Quinazolines; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Cells, Cultured; Uncoupling Protein 2 | 2019 |
A concise synthesis and biological study of evodiamine and its analogues.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemistry Techniques, Synthetic; Evodia; Humans; Liver Neoplasms; Quinazolines | 2019 |
Evodiamine inhibits migration and invasion by Sirt1-mediated post-translational modulations in colorectal cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Sirtuin 1; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Preventive Effects of Evodiamine on Dexamethasone-Induced Osteoporosis in Zebrafish.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Bone Remodeling; Calcification, Physiologic; Calcium; Dexamethasone; Glucocorticoids; Hydroxyproline; Larva; Matrix Metalloproteinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Quinazolines; Signal Transduction; Tartrate-Resistant Acid Phosphatase; Zebrafish | 2019 |
Gene regulation analysis of the effects of evodiamine on tongue squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Oligonucleotide Array Sequence Analysis; Quinazolines; Tongue Neoplasms | 2019 |
Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Caspase 3; Gene Expression Regulation; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; Kidney; Male; NF-kappa B; Oxidative Stress; Quinazolines; Rats; Rats, Wistar; Reactive Oxygen Species; Renal Artery; Reperfusion Injury; Surgical Instruments; Treatment Outcome; Tumor Necrosis Factor-alpha | 2019 |
Evodiamine in combination with histone deacetylase inhibitors has synergistic cytotoxicity in thyroid carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Quinazolines; Reactive Oxygen Species; Thyroid Neoplasms | 2019 |
Analysis of Evodiae Fructus by capillary electrochromatography-mass spectrometry with methyl-vinylimidazole functionalized organic polymer monolilth as stationary phases.
Topics: Acetonitriles; Ammonia; Calibration; Capillary Electrochromatography; Drugs, Chinese Herbal; Electrolytes; Evodia; Fruit; Hydrogen-Ion Concentration; Imidazoles; Indole Alkaloids; Limit of Detection; Limonins; Mass Spectrometry; Polymers; Quinazolines; Reference Standards; Reproducibility of Results | 2019 |
Development of EGFR-targeted evodiamine nanoparticles for the treatment of colorectal cancer.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Male; Mice; Mice, Inbred ICR; Molecular Structure; Neoplasms, Experimental; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Growth inhibitor of human hepatic carcinoma HepG2 cells by evodiamine is associated with downregulation of PRAME.
Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Survival; Down-Regulation; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Quinazolines; RNA, Messenger | 2019 |
Screening of cathepsin B inhibitors in traditional Chinese medicine by capillary electrophoresis with immobilized enzyme microreactor.
Topics: Amaryllidaceae Alkaloids; Cathepsin B; Drug Discovery; Drugs, Chinese Herbal; Electrophoresis, Capillary; Enzymes, Immobilized; Feasibility Studies; Indole Alkaloids; Indolizines; Kaempferols; Molecular Docking Simulation; Quinazolines; Theophylline | 2019 |
Evodiamine Eliminates Colon Cancer Stem Cells via Suppressing Notch and Wnt Signaling.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Neoplastic Stem Cells; Quinazolines; Receptors, Notch; Signal Transduction; Wnt Proteins | 2019 |
Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Drug Design; G2 Phase; HCT116 Cells; Humans; Mice; Quinazolines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tubulin Modulators; Xenograft Model Antitumor Assays | 2020 |
[Evodiamine inhibits injury of HUVECs induced by lipopolysaccharide through TLR4/NF-κB signaling pathway].
Topics: Cells, Cultured; Human Umbilical Vein Endothelial Cells; Humans; Lipopolysaccharides; Nitric Oxide; Quinazolines; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA | 2019 |
BMP9 mediates the anticancer activity of evodiamine through HIF‑1α/p53 in human colon cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Growth Differentiation Factor 2; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Phosphorylation; Quinazolines; Tumor Suppressor Protein p53; Up-Regulation; Xenograft Model Antitumor Assays | 2020 |
Effects of evodiamine on PI3K/Akt and MAPK/ERK signaling pathways in pancreatic cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Humans; Mice; Mice, Nude; Microtubule-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2020 |
Evodiamine suppresses Notch3 signaling in lung tumorigenesis via direct binding to γ-secretases.
Topics: A549 Cells; Amyloid Precursor Protein Secretases; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Survival; Evodia; Female; Humans; Lung Neoplasms; Mice, Inbred Strains; Molecular Docking Simulation; Quinazolines; Receptor, Notch3; Signal Transduction; Urethane | 2020 |
Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance.
Topics: Animals; Arthritis, Experimental; Interleukin-10; Interleukin-6; Joints; Male; Quinazolines; Rats; Rats, Inbred Lew; STAT3 Transcription Factor; STAT5 Transcription Factor; Synovial Membrane; Synovitis; T-Lymphocytes, Regulatory; Th17 Cells; Tumor Necrosis Factor-alpha | 2020 |
Evodiamine inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells via the Hippo-Yes-Associated Protein signaling pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Female; Hep G2 Cells; Hippo Signaling Pathway; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Protein Serine-Threonine Kinases; Quinazolines; Signal Transduction; Transcription Factors; Xenograft Model Antitumor Assays; YAP-Signaling Proteins | 2020 |
Combined effects of berberine and evodiamine on colorectal cancer cells and cardiomyocytes in vitro.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Berberine; Caco-2 Cells; Cardiotoxicity; Colon; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Drug Synergism; Drugs, Chinese Herbal; Epithelial Cells; HT29 Cells; Humans; Intestinal Mucosa; Myocytes, Cardiac; Quinazolines; Rats | 2020 |
Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response.
Topics: Analgesics; Animals; Hyperalgesia; Male; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitroglycerin; Pain; Periaqueductal Gray; Quinazolines; Rats, Sprague-Dawley; Receptors, AMPA | 2020 |
Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; DNA Damage; Down-Regulation; Gene Expression Regulation, Neoplastic; Gene Silencing; Hepatocyte Growth Factor; Humans; Male; Models, Biological; Neoplasm Proteins; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-met; Quinazolines; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor | 2020 |
Development and in-vitro evaluation of co-loaded berberine chloride and evodiamine ethosomes for treatment of melanoma.
Topics: Animals; Berberine; Drug Delivery Systems; Drug Development; Female; Humans; Liposomes; Melanoma, Experimental; Mice; Middle Aged; Plant Extracts; Quinazolines; Skin Absorption | 2020 |
Evodiamine Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in BV-2 Cells via Regulating AKT/Nrf2-HO-1/NF-κB Signaling Axis.
Topics: Animals; Cell Line; Cell Nucleus; Cell Survival; Heme Oxygenase-1; Inflammation; Inflammation Mediators; Lipopolysaccharides; Mice; Models, Biological; Neuroglia; Neurons; NF-E2-Related Factor 2; NF-kappa B; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrosine 3-Monooxygenase; Up-Regulation | 2021 |
Evodiamine has therapeutic efficacy in ulcerative colitis by increasing Lactobacillus acidophilus levels and acetate production.
Topics: Acetates; Animals; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Fecal Microbiota Transplantation; Feces; Gastrointestinal Agents; Gastrointestinal Microbiome; Inflammation Mediators; Intestinal Mucosa; Lactobacillus acidophilus; Male; Metabolomics; Quinazolines; Rats, Sprague-Dawley; Ribotyping | 2020 |
[Preparation of evodiamine-glycyrrhizic acid micelles with glycyrrhizic acid as carrier and their anti-hepatic fibrosis activity].
Topics: Animals; Drug Carriers; Glycyrrhizic Acid; Liver Cirrhosis; Micelles; Particle Size; Quinazolines; Rats; Solubility | 2020 |
Combination of Evodiamine with Berberine Reveals a Regulatory Effect on the Phenotypic Transition of Colon Epithelial Cells Induced by CCD-18Co.
Topics: Actins; Berberine; Biomarkers; Cadherins; Cell Line; Cell Movement; Colon; Epithelial Cells; Epithelial-Mesenchymal Transition; Fluorescence; Humans; Phenotype; Quinazolines; Signal Transduction; Smad Proteins; Transcription Factors; Transforming Growth Factor beta1; Wound Healing | 2020 |
Deep-Learning-Assisted Assessment of DNA Damage Based on Foci Images and Its Application in High-Content Screening of Lead Compounds.
Topics: Biological Products; Chalcones; Deep Learning; DNA Damage; Drug Evaluation, Preclinical; Flavonoids; Gene Expression Regulation; Green Fluorescent Proteins; HeLa Cells; Humans; Image Processing, Computer-Assisted; Medicine, Chinese Traditional; Optical Imaging; Plant Extracts; Quinazolines; Recombinant Fusion Proteins; Small Molecule Libraries; Tumor Suppressor p53-Binding Protein 1 | 2020 |
[Evodiamine Promotes Apoptosis of Glioma SHG-44 Cells and Its Mechanism].
Topics: Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation; Glioma; Humans; Quinazolines | 2020 |
Evodiamine suppresses non-small cell lung cancer by elevating CD8
Topics: Animals; Carcinoma, Non-Small-Cell Lung; CD8-Positive T-Lymphocytes; Down-Regulation; Female; Humans; Lung Neoplasms; Mice; Mucin-1; Plant Extracts; Programmed Cell Death 1 Receptor; Quinazolines; Transfection | 2020 |
Evodiamine inhibits high-fat diet-induced colitis-associated cancer in mice through regulating the gut microbiota.
Topics: Animals; Colitis-Associated Neoplasms; Diet, High-Fat; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Humans; Mice; Plant Extracts; Quinazolines | 2021 |
Evodiamine inhibits vasculogenic mimicry in HCT116 cells by suppressing hypoxia-inducible factor 1-alpha-mediated angiogenesis.
Topics: Animals; Antigens, CD; Cadherins; Cell Movement; Cell Survival; Epithelial-Mesenchymal Transition; Female; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice, Inbred BALB C; Neovascularization, Pathologic; Quinazolines; Vascular Endothelial Growth Factor A; Wound Healing | 2021 |
Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; HCT116 Cells; HSP70 Heat-Shock Proteins; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Neoplasms; Neoplastic Stem Cells; Quinazolines; Signal Transduction; Transcription, Genetic; Up-Regulation | 2021 |
Evodiamine protects against airway remodelling and inflammation in asthmatic rats by modulating the HMGB1/NF-κB/TLR-4 signalling pathway.
Topics: Airway Remodeling; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Evodia; HMGB1 Protein; Inflammation; NF-kappa B; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Design, synthesis, and biological evaluation of 3',4',5'-trimethoxy evodiamine derivatives as potential antitumor agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Molecular Structure; Quinazolines; Structure-Activity Relationship | 2021 |
Effect of Evodiamine on Rat Colonic Hypermotility Induced by Water Avoidance Stress and the Underlying Mechanism.
Topics: Animals; Avoidance Learning; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Male; Molecular Structure; Muscle Contraction; Quinazolines; Rats; Rats, Wistar; Stress, Psychological; Structure-Activity Relationship | 2021 |
Evodiamine alleviates lipopolysaccharide-induced pulmonary inflammation and fibrosis by activating apelin pathway.
Topics: Animals; Apelin; Apoptosis; Cytokines; Evodia; Fibrosis; Humans; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Pneumonia; Quinazolines; RAW 264.7 Cells | 2021 |
Structural simplification of evodiamine: Discovery of novel tetrahydro-β-carboline derivatives as potent antitumor agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbolines; Cell Proliferation; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; HCT116 Cells; Humans; Male; Mice, Nude; Molecular Structure; Neoplasms; Proof of Concept Study; Quinazolines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Xenograft Model Antitumor Assays | 2021 |
Evodiamine Inhibits
Topics: Antigens, Bacterial; Cell Nucleus; Cytokines; Helicobacter Infections; Helicobacter pylori; Humans; Inflammation; Interleukin-8; MAP Kinase Signaling System; Microbial Sensitivity Tests; NF-kappa B; NF-kappa B p50 Subunit; Quinazolines; Signal Transduction; Subcellular Fractions; Type IV Secretion Systems | 2021 |
Intranasal co-delivery of berberine and evodiamine by self-assembled thermosensitive in-situ hydrogels for improving depressive disorder.
Topics: Administration, Intranasal; Animals; Berberine; Depressive Disorder; Hydrogels; Mice; Quinazolines; Rats; Temperature | 2021 |
Water-soluble derivatives of evodiamine: Discovery of evodiamine-10-phosphate as an orally active antitumor lead compound.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Female; HCT116 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Phosphates; Quinazolines; Solubility; Structure-Activity Relationship; Water | 2021 |
Neuroprotective Studies of Evodiamine in an Okadaic Acid-Induced Neurotoxicity.
Topics: Alzheimer Disease; Animals; Apoptosis; Brain; Cell Line; Cognition; Cognition Disorders; Disease Models, Animal; Humans; Male; Maze Learning; Mice; Mice, Inbred ICR; Neurodegenerative Diseases; Neurons; Neuroprotection; Neuroprotective Agents; Okadaic Acid; Phosphorylation; Quinazolines; Spatial Memory; tau Proteins; Tauopathies | 2021 |
A novel evodiamine amino derivative as a PI3K/AKT signaling pathway modulator that induces apoptosis in small cell lung cancer cells.
Topics: Administration, Oral; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Signal Transduction; Small Cell Lung Carcinoma | 2021 |
Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum.
Topics: Animals; Cricetulus; Guinea Pigs; Indole Alkaloids; Interstitial Cells of Cajal; Peristalsis; Quinazolines | 2021 |
Design, synthesis and bioactivity study of evodiamine derivatives as multifunctional agents for the treatment of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Nude; Molecular Structure; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
Evodiamine Relieve LPS-Induced Mastitis by Inhibiting AKT/NF-κB p65 and MAPK Signaling Pathways.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Female; Lipopolysaccharides; Mastitis; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Proto-Oncogene Proteins c-akt; Quinazolines; Random Allocation; Signal Transduction; Transcription Factor RelA | 2022 |
The anti-tumor effects of evodiamine on oral squamous cell carcinoma (OSCC) through regulating advanced glycation end products (AGE) / receptor for advanced glycation end products (RAGE) pathway.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Female; Glycation End Products, Advanced; Humans; Mice; Mice, Nude; Mouth Neoplasms; Quinazolines; Receptor for Advanced Glycation End Products; Signal Transduction | 2021 |
Design, synthesis and biological evaluation of novel evodiamine and rutaecarpine derivatives against phytopathogenic fungi.
Topics: Antifungal Agents; Ascomycota; Botrytis; Dose-Response Relationship, Drug; Drug Design; Fusarium; Indole Alkaloids; Microbial Sensitivity Tests; Molecular Structure; Quinazolines; Rhizoctonia; Structure-Activity Relationship | 2022 |
Identification of evodiamine as a suppressor of prostate cancer progression by reducing AR transcriptional activity via targeting Src.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Male; Prostate; Prostatic Neoplasms; Quinazolines; Receptors, Androgen | 2022 |
[Research progress in pharmacology and toxicology of evodiamine].
Topics: Evodia; Hand Dermatoses; Humans; Plant Extracts; Quinazolines; Tinea | 2021 |
Design, synthesis and bioactivity evaluation of novel evodiamine derivatives with excellent potency against gastric cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Quinazolines; Stomach Neoplasms; Structure-Activity Relationship | 2022 |
Discovery of Novel Polycyclic Heterocyclic Derivatives from Evodiamine for the Potential Treatment of Triple-Negative Breast Cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Female; Heterocyclic Compounds; Humans; Polycyclic Compounds; Quinazolines; Triple Negative Breast Neoplasms | 2021 |
Evodiamine Lowers Blood Lipids by Up-Regulating the PPARγ/ABCG1 Pathway in High-Fat-Diet-Fed Mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 1; Bile Acids and Salts; Body Weight; Diet, High-Fat; Lipids; Liver; Mice; Plant Extracts; PPAR gamma; Quinazolines | 2021 |
[Cytotoxicity and underlying mechanism of evodiamine in HepG2 cells].
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 11; Caspase 3; Caspase 9; Cholestasis; Hep G2 Cells; Humans; Lipid Peroxidation; Liver; Molecular Docking Simulation; Multidrug Resistance-Associated Protein 2; Quinazolines | 2021 |
Synthesis of ring opening of evodiamine derivatives and evaluation on their biological activity.
Topics: Evodia; Plant Extracts; Quinazolines | 2022 |
A Critical YAP in Malignancy of HCC Is Regulated by Evodiamine.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mitochondria; Quinazolines; Up-Regulation; YAP-Signaling Proteins | 2022 |
Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Quinazolines; Structure-Activity Relationship | 2022 |
Discovery of evodiamine derivatives as potent insecticide candidates.
Topics: Animals; Calcium; Insecticides; Larva; Molecular Structure; Moths; Quinazolines; Rotenone; Ryanodine Receptor Calcium Release Channel | 2022 |
Discovery of novel bis-evodiamine derivatives with potent antitumor activity.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Quinazolines; Structure-Activity Relationship | 2022 |
The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in rats.
Topics: Animals; Berberine; Diet, High-Fat; Gastrointestinal Microbiome; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Quinazolines; Rats | 2022 |
Serum untargeted metabolomics analysis of the mechanisms of evodiamine on type 2 diabetes mellitus model rats.
Topics: Amino Sugars; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glutathione; Metabolomics; Nucleotides; Proline; Quinazolines; Rats; Streptozocin; Tryptophan | 2022 |
Design, synthesis and bioactivity evaluation of favorable evodiamine derivative scaffold for developing cancer therapy.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Molecular Structure; Neoplasms; Quinazolines; Structure-Activity Relationship | 2022 |
Upregulation of SIRT1 by Evodiamine activates PI3K/AKT pathway and blocks intervertebral disc degeneration.
Topics: Apoptosis; Cells, Cultured; Humans; Interleukin-6; Intervertebral Disc; Intervertebral Disc Degeneration; Lipopolysaccharides; Nucleus Pulposus; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Sirtuin 1; Tumor Necrosis Factor-alpha; Up-Regulation | 2022 |
Evodiamine inhibits stemness and metastasis by altering the SOX9-β-catenin axis in non-small-cell lung cancer.
Topics: Alkaloids; Apoptosis; beta Catenin; Cadherins; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cysteine; Humans; Lung Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Reactive Oxygen Species; SOX9 Transcription Factor; Vimentin | 2022 |
Effect of Evodiamine on Collagen-Induced Platelet Activation and Thrombosis.
Topics: Animals; Blood Platelets; Collagen; Mice; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinazolines; Thrombosis | 2022 |
Evodiamine prevents traumatic brain injury through inhibiting oxidative stress via PGK1/NRF2 pathway.
Topics: Animals; Apoptosis; Brain Injuries, Traumatic; Heme Oxygenase-1; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; Phosphoglycerate Kinase; Quinazolines; Rats | 2022 |
Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study.
Topics: Antineoplastic Agents; Evodia; Indole Alkaloids; Ligands; Molecular Docking Simulation; Quinazolines; Quinazolinones | 2022 |