Compounds > quinazolines
Page last updated: 2024-08-21

quinazolines and epidermal growth factor

quinazolines has been researched along with epidermal growth factor in 510 studies

Research

Studies (510)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's31 (6.08)18.2507
2000's322 (63.14)29.6817
2010's154 (30.20)24.3611
2020's3 (0.59)2.80

Authors

AuthorsStudies
Ambroso, LA; Bridges, AJ; Connors, RW; Fry, DW; Kraker, AJ; Leopold, WR; McMichael, A; Nelson, JM1
Bollen, M; De Smedt, H; Himpens, B1
Bridges, AJ; Cody, DR; Denny, WA; Fry, DW; Kraker, AJ; McMichael, A; Rewcastle, GW; Showalter, HD; Zhou, H1
Bridges, AJ; Denny, WA; Fry, DW; Kraker, AJ; McMichael, A; Nelson, J; Palmer, BD; Rewcastle, GW; Showalter, HD; Sun, L1
Chelluderai, B; Dutta, S; Fligiel, SE; Jaszewski, R; Majumdar, AP; Tureaud, J1
Böhmer, FD; Fernández, LE; Greiser, U; Lage, A; Perez, R; Sánchez, B; Suarez Pestana, E1
Hollenberg, MD; Zheng, XL1
Klein, JM; McCarthy, TA1
Fridman, R; Kondapaka, SB; Reddy, KB1
Levitzki, A; Osherov, N1
Berthelemy, M; Dangles, V; Féménia, F; Lainé, V; Le Rhun, D; Levy, D; Poupon, MF; Schwartz-Cornil, I1
Elder, J; Garner, W; Stoll, S1
Breu, J; Muchnicki, L; Slack, BE; Wurtman, RJ1
Higashimoto, Y; Kanayama, S; Kiyohara, T; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Sugimachi, M; Tsutsui, S; Zushi, S1
Hamacher, L; Peus, D; Pittelkow, MR1
Hollenberg, MD; Renaux, B; Zheng, XL1
Earp, HS; Graves, LM; Lee, JW; Li, X1
DeWild, LJ; Klein, JM; McCarthy, TA1
Liu, XP; Myers, DE; Narla, RK; Uckun, FM1
Soltoff, SP1
Dalmau, SR; Freitas, CS; Savino, W1
Higashimoto, Y; Kanayama, S; Kiyohara, T; Kondo, S; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Sugimachi, M; Zushi, S1
Klis, D; Liu, XP; Narla, RK; Uckun, FM1
Fukuda, N; Hu, WY; Izumi, Y; Kanmatsuse, K; Soma, M1
Farrell, GC; Zhang, BH1
Ahola, H; Carlstedt-Duke, J; Modéer, T; Yucel-Lindberg, T1
Allal, C; Asslan, R; Favre, G; Le Gaillard, F; Pradines, A; Pratx, C1
Avner, ED; Frost, P; Futey, L; Sweeney, WE1
Gillham, H; Golding, MC; Gullick, WJ; Pepperkok, R1
Greenberg, NM; Kassis, J; Kim, HG; Lo, H; Moellinger, J; Wells, A1
Polk, DB; Tong, W1
Ogata, T1
Daaka, Y; Lefkowitz, RJ; Luttrell, LM; Maudsley, S; Pierce, KL1
Guo, C; Luttrell, LM; Price, DT1
Abe, K; Saito, H1
Jensen, RL; Petr, M; Wurster, RD1
Dorko, K; Esplen, JE; Jo, M; Michalopoulos, GK; Stolz, DB; Strom, SC1
Albala, DM; Jahoda, A; Koleski, FC; Turk, TM; Wojcik, E1
Jope, RS; Song, L; Zhang, L1
Carpenter, G; Ji, QS1
Dalbone, AC; Hutcheon, AE; Takahashi, H; Zieske, JD1
Abraham, JA; Clowes, AW; Daum, G; Kalmes, A; Vesti, BR1
Bates, SE; Bishop, PC; Blagosklonny, MV; Fojo, T; Robey, R1
del Carmen Medina, L; García-Sáinz, JA; Vázquez-Prado, J1
Bagnato, A; Catt, KJ; Tecce, R; Vacca, F1
Brattain, MG; Jackson, JG; Koterba, AP; Kreisberg, JI; Yee, D1
Delouvée, A; el-Marjou, A; Radvanyi, F; Thiery, JP1
Fujiyama, S; Higashiyama, S; Iba, O; Iwasaka, T; Jyo, N; Koyama, Y; Maruyama, K; Masaki, H; Matsubara, H; Mori, Y; Nose, A; Nozawa, Y; Ogata, N; Tateishi, E; Tsutsumi, Y; Uchiyama, Y1
Ghosh, S; Liu, XP; Myers, DE; Sudbeck, EA; Uckun, FM; Zheng, Y1
Berven, LA; Crouch, MF; Davy, DA; Willard, FS1
Diao, C; Hollenberg, MD; Matsubara, S; Wong, NC; Zheng, XL1
Adrian, TE; Cluck, MW; Knezetic, JA; Larsson, J; Lovas, S; Murphy, LO; Murphy, RF; Otvös, F; Permert, J; Schally, AV1
Amir, C; Bowers, G; Dent, P; Hewitt, T; Lammering, G; Mikkelsen, RB; Reardon, D; Schmidt-Ullrich, RK; Valerie, K1
Huggett, TM; Jost, M; Kari, C; Rodeck, U1
Du, X; Jiang, Y; Lu, X; Qian, W; Walsh, JP1
Klar, U; Lichtner, RB; Menrad, A; Schneider, MR; Sommer, A1
Adachi, H; Fujioka, T; Kim, JH; Saito, K; Tsujimoto, M; Ui, M; Yokoyama, S1
Norman, P1
Brattain, MG; Ghosh, P; Humphrey, LE; Kreisberg, JI; Sawhney, RS; Zhou, GH1
Bulloch, AG; Hermann, PM; Wildering, WC1
Ahmad, T; Anderson, NG; Bundred, NJ; Chan, K; Dobson, R1
Gildea, JJ; Gulding, KM; Harding, MA; Seraj, MJ; Theodorescu, D1
Alberto Olivares-Reyes, J; Catt, KJ; Shah, BH; Yesilkaya, A1
Carreras, I; DiCamillo, SJ; Foster, JA; Nugent, MA; Panchenko, MP; Panchenko, MV; Stone, PJ1
Gee, JM; Nicholson, RI; Wakeling, AE1
Hirata, A; Kometani, T; Kuwano, M; Kuwano, T; Naito, S; Ogawa, S; Ono, M1
Baselga, J2
Assender, J; Barrow, D; Dewhurst, OL; Dutkowski, CM; Glynne-Jones, E; Goddard, L; Harper, ME; Nicholson, RI; Wakeling, AE1
Bundred, N; Gilmore, AP; Korsmeyer, SJ; O'Hare, MJ; Ranger, AM; Streuli, CH; Valentijn, AJ; Wakeling, A; Wang, P1
Sánchez De Cos Escuín, J1
Fleck, C; Hilger, R; Jurkutat, S; Karge, E; Merkel, U; Schimske, A; Schubert, J1
Alligood, KJ; Keith, BR; Liu, LH; Ma, H; Mullin, RJ; Owens, G; Rusnak, DW; Spector, NL; Xia, W1
Katoh, O; Lu, H; Uesaka, T; Watanabe, H1
Chen, MC; Kui, R; Perez Salazar, E; Rozengurt, E; Soll, AH; Solomon, TE1
Jänne, PA; Johnson, BE; Salgia, R; Taffaro, ML1
Morris, C1
Wilkinson, E1
Couzin, J1
Koty, PP; Lei, W; Levitt, ML1
Castro, M1
Affleck, K; Alligood, KJ; Gilmer, TM; Keith, BR; Knight, WB; Lackey, K; Mullin, RJ; Murray, DM; Rhodes, N; Rusnak, DW; Wood, ER1
Alonso, A; Dürst, M; Leykauf, K1
Jean-Claude, BJ; Matheson, SL; McNamee, JP1
Collins, JF; Ghishan, FK; Hines, ER; Inouye, M; Xu, H1
Hynes, NE; Motoyama, AB1
Cullinane, C; Hagekyriakou, J; McArthur, GA; Solomon, B; Stacker, SA; Trivett, MK1
Dummer, R; Follath, F; Jacky, E; Trojan, A1
Dartt, DA; Hodges, RR; Tepavcevic, V; Zoukhri, D1
Bringmann, A; Milenkovic, I; Reichenbach, A; Weick, M; Wiedemann, P1
Chung, T; Dent, P; Hagan, MP; Hinman, D; McKinstry, R; Yacoub, A1
Fujiwara, K; Hamasaki, S; Kiura, K; Tabata, M; Tanimoto, M; Ueoka, H1
Lavelle, F1
Lorita, J; Pareja, M; Ramírez, I; Sánchez, O; Soley, M1
Angelucci, A; Bologna, M; Festuccia, C; Gravina, GL; Marronaro, A; Vicentini, C1
Chan, SY; Mak, KK1
Ahmed, I; Drezner, MK; Gesty-Palmer, D; Luttrell, LM1
Almqvist, Y; Carlsson, J; Sundberg, AL; Tolmachev, V1
Arteaga, CL; Johnson, DH1
Averbuch, S; Baselga, J; Dong, RP; Douillard, JY; Eek, R; Feyereislova, A; Fukuoka, M; Giaccone, G; Horai, T; Kudoh, S; Macleod, A; Nakagawa, K; Nishiwaki, Y; Noda, K; Rischin, D; Smit, E; Takata, I; Tamura, T; Vansteenkiste, J; Yano, S1
Bernardino, CR; Chang, EL; Dartt, DA; Hodges, RR; Horikawa, Y; Rios, JD; Rubin, PA; Shatos, MA; Zoukhri, D1
Carbone, D; Heelan, RT; Johnson, DH; Kris, MG; Krozely, P; Krug, LM; Miller, VA; Ochs, J; Perez, W; Pizzo, B; Sandler, A; Smith, R; Tyson, L1
Androulakis, N; Bozionelou, V; Georgoulias, V; Kouroussis, C; Mavroudis, D; Pallis, AG; Souglakos, J; Vlachonikolis, IG1
Fujii, K; Kihara, N; Kohrogi, H; Matsumoto, M; Okamoto, I; Suga, M; Terasaki, Y1
Hénichart, JP; Mimeault, M; Pommery, N1
Douglass, EC1
Aono, Y; Azuma, M; Kanematsu, T; Miki, T; Sone, S; Uehara, H; Yamamoto, A; Yano, S1
Conzen, SD; Coticchia, CM; Dickson, RB; Nishanian, TG; Ramljak, D; Ringel, MD; Saji, M1
Batist, G; Daneshmand, M; Goss, G; Hirte, HW; Lorimer, IA; Major, P; Matthews, S; Miller, WH; Parolin, DA; Seymour, L; Stewart, D1
Ardizzoni, A; Bartolini, S; Calandri, C; Cappuzzo, F; Crinò, L; Gridelli, C; Maione, P; Santoro, A; Soto-Parra, H; Tiseo, M1
Behnken, D; Govindan, R; McLeod, H; Read, W1
Attoub, S; Bruyneel, E; Emami, S; Gespach, C; Mareel, M; May, FE; Nguyen, QD; Rodrigue, CM; Rodrigues, S; Thim, L; Westley, BR1
Bonomi, P1
Ciccolini, J; Dubreuil, A; Etienne, MC; Fischel, JL; Formento, JL; Formento, P; Francoual, M; Magné, N; Milano, G; Renée, N; Tiffon, C1
Baumann, M; Krause, M; Thames, HD1
Almqvist, Y; Blomquist, E; Carlsson, J; Gedda, L; Jensen, HJ; Orlova, A; Sundberg, AL; Tolmachev, V1
Gemma, A; Kudoh, S; Yoshimura, A1
Amorino, GP; Contessa, JN; Dent, P; Hewit, TH; Lammering, G; Schmidt-Ullrich, RK; Valerie, K1
Barrow, D; Gee, JM; Harper, ME; Hutcheson, IR; Jordan, N; Knowlden, JM; Madden, TA; McClelland, RA; Nicholson, RI; Wakeling, AE1
Bromberg, PA; Dailey, LA; Graves, LM; Samet, JM; Sheppard, D; Silbajoris, R; Wu, W1
Abbou, CC; Chopin, DK; Daher, A; de Boer, WI; El-Marjou, A; Radvanyi, F; Thiery, JP; van der Kwast, T1
Degen, SJ; Hill, KJ; Peace, BE; Waltz, SE1
Endo, H; Hida, T; Masuda, A; Mitsudomi, T; Nakagawa, T; Sugiura, T; Suzuki, T; Takahashi, T; Yatabe, Y1
Gui, Y; Zheng, XL1
Basso, A; Moasser, MM; She, QB; Solit, D1
Mattingly, RR; Menard, RE1
Campiglio, M; Fumagalli, M; Gianni, L; Locatelli, A; Ménard, S; Normanno, N; Olgiati, C; Somenzi, G; Viganò, L1
Blackledge, G1
Ahmed Rasheed, BK; Bigner, DD; Dancey, JE; Dowell, JM; Friedman, AH; Friedman, HS; Herndon, JE; Kao, JC; McLendon, RE; Peery, T; Penne, KL; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Stenzel, TT; Tourt-Uhlig, SE; Van Duyn, LB; Vredenburgh, JJ; Wikstrand, CJ1
Dong, RP; Yamaguchi, M; Yano, S1
Natale, RB1
Sandler, AB1
Schiller, JH1
Khuri, FR1
Ambrad, AA; Carey, S; Falsey, R; Glanzberg, H; Kislin, K; Martinez, JD; Meuillet, EJ; Patel, J; Stea, B1
Alloisio, M; Campagnoli, E; Cavina, R; Ferrari, B; Ginanni, V; Latteri, F; Morenghi, E; Pedicini, V; Ravasi, G; Roncalli, M; Santoro, A; Soto Parra, HJ; Zucali, PA1
Ashida, M; Bito, T; Budiyanto, A; Ichihashi, M; Kunisada, M; Ueda, M1
Kurebayashi, J; Okubo, S; Otsuki, T; Sonoo, H; Tanaka, K; Yamamoto, Y1
Kurebayashi, J; Okubo, S; Sonoo, H; Yamamoto, Y1
González, A; Guerrero, J; Martínez, J; Santibañez, JF1
Vansteenkiste, J1
Adam, L; Bagheri-Yarmand, R; Barnes, CJ; Clayman, GL; El-Naggar, A; Hong, WK; Kumar, R; Lotan, R; Papadimitrakopoulou, VV; Wang, RA; Yang, Z1
Haraguchi, N; Kikuchi, N; Kodama, T; Satoh, H; Sekizawa, K1
Belani, CP; Ramalingam, S1
Ochs, JS1
Averbuch, S; Kelly, K1
Brahimi, F; Jean-Claude, BJ; Matheson, SL1
Azzoli, C; Ben-Porat, L; Gomez, J; Heelan, RT; Kris, MG; Krug, LM; Memoli, N; Miller, VA; Pao, W; Patel, J; Pizzo, B; Rizvi, N; Rusch, V; Shah, N; Tyson, L; Venkatraman, E; Zakowski, M1
Choi, JH; Kim, SW; Koh, JK; Lee, HW; Lee, MW; Moon, KC; Seo, CW; Yang, HJ1
Diggle, C; Holder, J; Lee, WC; Selby, PJ; Southgate, J; Stahlschmidt, J; Trejdosiewicz, LK; Varley, CL1
Ranson, M; Wardell, S1
Cho, YM; Foley, J; Gocken, TA; Koltz, PF; Konger, RL; Lewis, DA; Richard, V; Rosol, TJ; Spandau, DF1
Dowlati, A; Kern, JA; Nethery, D1
Fujii, T; Hirata, A; Kinoshita, H; Kometani, T; Kuwano, M; Miyagawa, M; Ono, M; Ueda, S1
Lazarowicz, HP; Lunec, J; Mellon, JK; Nutt, JE1
Fidias, P; Gurubhagavatula, S; Jänne, PA; Johnson, BE; Lucca, J; Lynch, TJ; Ostler, P; Skarin, AT; Yeap, BY1
Perras, C1
Bell, DW; Brannigan, BW; Christiani, DC; Gurubhagavatula, S; Haber, DA; Haluska, FG; Harris, PL; Haserlat, SM; Louis, DN; Lynch, TJ; Okimoto, RA; Settleman, J; Sordella, R; Supko, JG1
Rozengurt, E; Santiskulvong, C; Sinnett-Smith, J1
Siegfried, JM; Stabile, LP1
Chan, AS; Wong, YH1
Baker, M1
Gazdar, AF; Herz, J; Minna, JD; Sprang, SR1
Campagnoli, E; Cavina, R; Grimaldi, GC; Latteri, F; Morenghi, E; Parra, HS; Roncalli, M; Santoro, A; Zucali, PA1
Hayes, DF1
Ali, S; Massarweh, S; Osborne, CK; Schiff, R; Shou, J; Wakeling, AE; Weiss, H1
Prydz, H; Wiiger, MT1
Evdonin, AL; Margulis, BA; Medvedeva, ND; Tsupkina, NV1
Giaccone, G1
Aderka, D; Levitt, ML; Pfeffer, MR1
Futreal, PA; Stratton, MR1
Hirata, A; Izumi, K; Kuwano, M; Naito, S; Ono, M; Uehara, H1
Chen, R; Morinelli, TA; Paul, RV; Ullian, ME; Webb, JG1
Baldi, E; Bonaccorsi, L; Forti, G; Marchiani, S; Muratori, M1
Kataoka, K; Kurabayashi, T; Kuribayashi, A; Miura, M1
Alimonti, A; Carlini, P; Cognetti, F; Di Cosimo, S; Fabi, A; Ferretti, G; Martinelli, E; Matar, P; Milella, M; Papaldo, P1
Bianco, AR; Bianco, C; Bianco, R; Bunn, P; Ciardiello, F; Cionini, L; D'Armiento, FP; Damiano, V; Melisi, D; Mignogna, C; Raben, D; Tortora, G1
Bowling, GH; Khan, SA; Millena, AC; Reddy, SC1
Pizzo, B1
Alaoui-Jamali, MA; Jean-Claude, BJ; Matheson, SL; McNamee, JP; Tari, AM; Wang, T1
Brahimi, F; Jean-Claude, BJ; Li, YJ; McNamee, JP; Qiu, Q; Rachid, Z; Tari, AM1
Bang, YJ; Chung, DH; Han, SW; Heo, DS; Hwang, PG; Im, SA; Kim, DW; Kim, NK; Kim, TY; Kim, YT1
Kolachana, P; Lawsin, LM; Moore, J; Perlman, A; Ringel, MD; Saji, M1
Senior, K1
Chang, GC; Chen, KC; Lin, YC; Wang, RC; Yang, TY; Yin, MC1
Baselga, J; Fukuoka, M; Herbst, RS1
Banasik, M; Dytnerska, K; Lewkowicz, N; Lewkowicz, P; Tchórzewski, H1
Bailey, C; Cantarini, MV; Marshall, AL; McFarquhar, T; Smith, RP1
Aoe, M; Doihara, H; Hara, H; Ishibe, Y; Shien, T; Shimizu, N; Taira, N; Takahashi, H; Teramoto, J; Yoshitomi, S1
Bryant, JA; Charles, AC; Cloughesy, TF; Finn, RS; Slamon, DJ1
Bazan, HE; Bazan, NG; Ottino, P; Sharma, GD1
Cadranel, J; Madelaine, J; Zalcman, G1
Blandin, S; Gérinière, L; Girard, N; Perrot, E; Souquet, PJ1
Barnard, GF; Inoue, H; Ishii, H; Ishikawa, K; Mimori, K; Mori, M; Ohta, M; Utsunomiya, T; Yamashita, K; Yoshinaga, K1
Bekele, BN; Doan, D; El-Naggar, AK; Holsinger, FC; Jasser, SA; Kim, S; Mandal, M; McMurphy, AB; Myers, JN; Schiff, BA; Sherman, SI; Yeung, SC; Yigitbasi, OG; Younes, MN; Zhou, G1
Barber, TD; Kinzler, KW; Velculescu, VE; Vogelstein, B1
Hoang-Xuan, K; Sanson, M; Thillet, J1
Hansen, FD; Nexø, E; Sørensen, BS; Tørring, N; Ørntoft, TF1
Abud, HE; Heath, JK; Watson, N1
Condeelis, J; Coniglio, S; Eddy, R; Kempiak, S; Lorenz, M; Miki, H; Sarmiento, C; Segall, J; Symons, M; Takenawa, T; Yamaguchi, H1
Angelucci, A; Bologna, M; Festuccia, C; Gravina, GL; Millimaggi, D; Muzi, P; Vicentini, C1
Cheng, J; Chu, EK; Drazen, JM; Foley, JS; Patel, AS; Tschumperlin, DJ1
Kishida, O; Kiyohara, T; Miyazaki, T; Miyazaki, Y; Murayama, Y; Ogasa, M; Shimomura, I; Shinomura, Y; Tsutsui, S; Watabe, K; Yamamoto, T1
Chen, L; Gao, P; Ma, D; Oppenheim, JJ; Sun, R; Wang, J; Zhang, N1
Grandis, JR; Gubish, CT; Lyker, JS; Siegfried, JM; Stabile, LP; Zhang, W1
Doi, S; Ikegami, Y; Itoh, A; Kitazaki, T; Kohno, S; Nakamura, Y; Nakatomi, K; Oka, M; Shiozawa, K; Soda, H; Tsurutani, J; Yoshida, H; Yoshikawa, M1
Dimitroulakos, J; Goss, G; Hanson, JE; Lagarde, AE; Lorimer, IA; Mantha, AJ1
Faj, D; Kurbel, S1
Choo, MK; Koizumi, K; Matsuo, M; Saiki, I; Sakurai, H; Ueno, Y1
Bell, DW; Haber, DA; Louis, DN; Riemenschneider, MJ1
Buck, DC; Macey, TA; Neve, KA; Wang, C; Yang, R1
Boulesteix, C; Gall, L; Germain, G; Ruffini, S1
Hill, G; Pellegrin, S; Selby, PJ; Shaw, NJ; Southgate, J; Trejdosiewicz, LK; Varley, C1
Angelucci, A; Biordi, L; Bologna, M; Festuccia, C; Gravina, GL; Millimaggi, D; Muzi, P; Vicentini, C1
Neufeld, AH; Zhang, X1
Fujioka, A; Itoh, RE; Kurokawa, K; Matsuda, M; Mayer, BJ; Sharma, A1
Brandt, R; Hynes, NE; Littlewood, A; O'Reilly, T; Schnell, C; Sini, P; Wood, J; Wyder, L1
El Shewy, H; Gesty-Palmer, D; Kohout, TA; Luttrell, LM1
Derby, S; Di, W; Jiang, Q; Qiu, L; Schefeller, E; Wan, Y; Wanebo, H; Wang, Q; Yan, B1
Batra, SK; Depreux, P; Hénichart, JP; Lin, MF; Mimeault, M; Moniaux, N; Moore, E1
Eicke, N; Emons, G; Gründker, C; Günthert, AR; Läsche, J; Olota, A1
Bunting, M; Hanson, BJ; Hanson, GT; O'Grady, M; Raha, D1
Greulich, H; Griffin, JD; Jänne, PA; Jiang, J; Meyerson, M; Sellers, WR1
Chen, YR; Chen, YT; Fu, YN; Hu, SF; Huang, SF; Lin, CH; Tsai, SF; Yang, ST1
Duvauchelle, T; Kerr, DJ; Laight, A; Ranson, M; Smith, RP; Swaisland, HC; Wilder-Smith, CH1
Kanazawa, S; Kinoshita, Y; Komiyama, Y; Muramatsu, M; Nomura, S; Yamaguchi, K1
Kim, HJ; Kim, JH1
Abdallah, R; Albitar, L; Laidler, LL; Leslie, KK1
Bozec, A; Ciccolini, J; Fanciullino, R; Fischel, JL; Formento, P; Milano, G; Murraciole, X; Padovani, L1
Akizawa, T; Hatamura, I; Negi, S; Orita, H; Saji, F; Sakaguchi, T; Shibata, M; Shiizaki, K1
Cai, K; Enomoto, A; Hosoi, Y; Li, Z; Matsumoto, Y; Miyagawa, K; Morita, A; Nakagawa, K; Tanno, Y1
Iwakura, Y; Jourdi, H; Nagano, T; Namba, H; Nawa, H; Takei, N; Xiong, H1
Gallo, RM; Gilmore, JL; Riese, DJ1
Bolotin, D; Chu, DH; Fuchs, E; Polak, L; Wang, X; Williams, T1
Gazdar, AF; Girard, L; Lee, W; Minna, JD; Peyton, M; Ramirez, RD; Sato, M; Shames, DS; Shay, JW; Sunaga, N; Vaughan, MB1
Bouaroud, N; Brahmer, J; Chan, A; Clark, DP; Forastiere, A; Hidalgo, M; Jimeno, A; Kincaid, E; Kulesza, P1
Bergmann, S; Henklein, P; Hollenberg, MD; Junker, K; Kaufmann, R; Settmacher, U1
Cerniglia, G; Gupta, A; Jiang, Z; Kao, GD; Maity, A; Pore, N1
Awooda, I; Barhoumi, R; Burghardt, RC; Mouneimne, Y; Safe, S1
Angelucci, C; Iacopino, F; Lama, G; Sica, G1
Casas-González, P; García-Sáinz, JA1
Chen, H; Fan, ST; Kok, TW; Liu, Y; Poon, RT; Shao, W; Sun, X1
Arteaga, CL; Carpenter, G; Gazdar, AF; Muthuswamy, SK; Narasanna, A; Perez-Torres, M; Wang, SE; Wu, FY; Xiang, B; Yang, S1
Herbst, R; Sandler, A1
Ashkenazi, H; Cao, X; Motola, S; Popliker, M; Tsafriri, A1
Bette, M; Folz, BJ; Mandic, R; Neubauer, A; Rodgarkia-Dara, CJ; Weihe, E; Werner, JA; Zhu, L1
Choi, SH; Lemmon, MA; Mendrola, JM1
Carotenuto, A; Cito, L; D'Alessio, A; De Luca, A; Guzzo, A; Maiello, MR; Napolitano, M; Normanno, N; Rachiglio, AM1
Agero, AL; Benvenuto-Andrade, C; Busam, KJ; Dusza, SW; Halpern, AC; Myskowski, P1
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Docheva, D; Eibl-Lindner, KH; Kampik, A; Kernt, M; Liegl, R; Wertheimer, C1
Jo, U; Kim, YH; Park, JK; Park, KH; Sung, JS; Whang, YM; Won, NH1
Borgmann, D; Höglinger, O; Lanzerstorfer, P; Schütz, G; Weghuber, J; Winkler, SM1
Koh, Y; Murakami, H; Serizawa, M; Takahashi, T; Watanabe, M; Yamamoto, N1
Gao, M; Ge, CH; Ge, ZQ; Li, CY; Wang, XH; Yang, XM; Yu, M; Zhan, YQ; Zhang, JH1
Han, D; Sun, J; Wang, F; Xiao, W; Zhu, Y1
Beaty, BT; Condeelis, JS; Cox, D; Eddy, RJ; Sharma, VP1
De, S; Dermawan, JK; Stark, GR1
Koskinen, PK; Palin, N; Rintala, JM; Rintala, SE; Savikko, J; von Willebrand, E1
Aldape, K; Berens, ME; Carrera-Silva, EA; Dietrich, JD; Errasti, AE; Ghosh, S; Gibbs, D; Hulme, C; Kusne, Y; Loftus, JC; Lu, Z; Mandell, EK; Perry, AS; Rothlin, CV; Rushing, EJ; Sanai, N; Yang, W1
Fang, Y; Febles, NK; Ferrie, AM1
Beckett, AJ; Clague, MJ; Coulson, JM; Prior, IA; Tang, WYY; Urbé, S1
Asbagh, LA; Baietti, MF; Budinska, E; De Vriendt, V; Hoe, N; Imjeti, NS; Jacobs, B; Sablina, A; Singh, S; Steklov, M; Tejpar, S; Vazquez, I; Vecchione, L; Zimmermann, P1
Alexander, PB; Chen, J; Chen, R; Radiloff, DR; Sun, T; Wang, XF; Wu, H; Xiang, H; Yang, P; Yuan, L1
Ito, S; Itoh, K; Nishimura, Y; Takiguchi, S1
Demehri, FR; Dempsey, PJ; Feng, Y; Freeman, JJ; Teitelbaum, DH1
Carella, N; Carr, BI; Cavallini, A; D'Alessandro, R; Lippolis, C; Messa, C; Refolo, MG1
Bailie, K; Bell, J; Comer, D; Douglas, I; Heaney, LG; Parker, JC; Shields, MD; Skibinski, G1
Croniger, CM; De, S; DeSantis, D; Li, X; Stark, GR; Zhou, H1
Li, CY; Li, X; Liu, JL; Qu, WS; Tian, DS; Wang, W; Xie, MJ1
Li, X; Liang, G; Liu, Z; Peng, K; Qian, Y; Skibba, M; Tian, X; Wang, J; Xu, Z; Zou, C1
Sui, JQ; Xie, KP; Xie, MJ1
Ma, Y; Shi, H; Yi, Y; Zhang, T1
Fujimoto, M; Imanaka-Yoshida, K; Kawakita, F; Liu, L; Nakasaki, A; Shiba, M; Shimojo, N; Suzuki, H; Yoshida, T1
Campion, CM; Cole, JA; Leon Carrion, S; Mamidanna, G; Sutter, CH; Sutter, TR1
Cao, XJ; Garcia, BA; Kharbanda, A; Runkle, KB; Stypulkowski, E; Wang, W; Witze, ES1
Conklin, DS; Khan, F; Kokabee, L; Sevinsky, CJ; Sun, Y; Wang, X; Wong, J1
Arai, J; Matsumoto, K; Miyazaki, T; Mochinaga, K; Nagasaki, T; Nagayasu, T; Nanashima, A; Tominaga, T; Tsuchiya, T; Tsukamoto, K; Yamasaki, N1
Al-Daccak, R; Antonicelli, F; Bastid, J; Bensussan, A; Cure, H; Fabre, J; Fuselier, C; Garbar, C; Giustiniani, J; Merrouche, Y1
Allison, JP; Cha, JH; Chan, LC; Chang, SS; Ding, Q; Hortobagyi, GN; Hsu, JL; Hsu, JM; Hung, MC; Khoo, KH; Kim, T; Kuo, CW; Lee, CC; Lee, HH; Li, CW; Lim, SO; Sahin, AA; Wang, Y; Wu, HJ; Wu, Y; Xia, W; Yamaguchi, H; Yao, J; Yu, D1
Chang, H; Kim, HS; Kim, JW; Lee, JS; Moon, SU; Sung, JH1
Chen, Z; Guan, S; Lu, J; Mao, X; Pang, JC; Tao, L; Vasudevan, SA; Woodfield, SE; Yang, J; Yu, Y; Zhang, F; Zhang, H; Zhao, Y1
Kannan, N; Katiyar, S; Ruan, Z1
Heath, JK; Pike, JA; Rappoport, JZ; Styles, IB1
Peng, H; Xia, L; Xiaoli, Z; Zhiqiang, L1
Chen, JK; Dong, G; Dong, Z; Liu, Y; Yao, Q; Zhang, H; Zhang, M; Zhang, W; Zhou, X1
Nakajima, M; Nozaki, M; Ohnishi, Y; Yasui, H1
Burgio, F; Faia-Torres, AB; Fontana, AO; Marchi, F; Paganetti, P; Pieles, U; Piffaretti, D; Pinton, S; Reinert, M1
Chacko, AR; Hilkens, J; Piyush, T; Rhodes, JM; Sindrewicz, P; Yu, LG1
Band, H; Band, V; Mirza, S; Mohibi, S; Srivastava, S1
Anderson, JC; Bellis, SL; Britain, CM; Holdbrooks, AT; Willey, CD1
Araldi, D; Ferrari, LF; Levine, JD1
Araujo Vieira, I; Brufatto Olguins, D; Brunetto de Farias, C; José Gregianin, L; Kersting, N; Kunzler Souza, B; Lunardi Brunetto, A; Pereira Dos Santos, R; Roesler, R; Schwartsmann, G; Tesainer Brunetto, A1
Gao, MY; Lin, C; Qin, Y; Wang, YF; Zhang, H1
Abisoye-Ogunniyan, A; Davis, M; Ghebremedhin, A; Grizzle, W; Jones-Trich, J; Karanam, B; Lin, H; Salam, AB; Theodore, S; Wang, H; Yates, C1
Hong, K; Huai, Z; Huang, Y; Li, S; Liu, F; Liu, G; Song, L; Xia, G; Xu, Y; Yao, M1
Cunha, SI; Jia, M; Souchelnytskyi, S1
Akin, JW; Brännström, M; Choi, Y; Curry, TE; Jo, M; Rosewell, KL1
Li, J; Liu, Y; Lu, J; Peng, Z; Zhang, L1
Barros Nunes, G; Chediek Dall'Acqua, P; Fábio Gouveia Nogueira, M; Fontes, PK; Lombardi Lopes, F; Marinho, M; Rodrigues da Silva, C; Zoccal Mingoti, G1
Golabiewska, E; Holownia, A; Niechoda, A; Rybak, A; Zarzecki, M1
Huang, W; Kong, H; Liu, P; Peng, LY; Xie, WP; Yang, MX; Yu, M; Zhou, H1
Bian, X; Li, X; Sun, Y; Tian, W; Tian, Y; Xu, J; Zhao, H1
Hasegawa, J; Hikita, T; Kugii, Y; Morioka, S; Nakanishi, H; Oneyama, C; Sakihara, T; Sasaki, J; Sasaki, T; Suzuki, A; Tokuda, E; Yamamoto, T; Yamazaki, M1

Reviews

38 review(s) available for quinazolines and epidermal growth factor

ArticleYear
Tyrosine kinase inhibitors against EGF receptor-positive malignancies.
    Methods in molecular biology (Clifton, N.J.), 2001, Volume: 166

    Topics: Adenocarcinoma; Amides; Aniline Compounds; Animals; Antineoplastic Agents; Breast Neoplasms; Drug Design; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Genistein; Humans; Leukemia; Macaca fascicularis; Mice; Mice, Inbred BALB C; Mice, SCID; Models, Molecular; Molecular Structure; Neoplasm Proteins; Neoplasms; Nitriles; Protein Conformation; Protein Structure, Tertiary; Quinazolines; Recombinant Fusion Proteins; Sequence Alignment; Species Specificity; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays

2001
The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.
    Oncogene, 2001, Mar-15, Volume: 20, Issue:11

    Topics: Autocrine Communication; Benzothiazoles; Breast Neoplasms; Carcinoma; Epidermal Growth Factor; ErbB Receptors; Female; Genes, erbB; Growth Substances; Humans; Neuregulin-1; Quinazolines; Radiation, Ionizing; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2001
Prospects for combining hormonal and nonhormonal growth factor inhibition.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:12 Suppl

    Topics: Antineoplastic Agents; Breast Neoplasms; Drug Therapy, Combination; Epidermal Growth Factor; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Gefitinib; Humans; Quinazolines; Tamoxifen

2001
[New therapeutic targets and strategies in lung cancer].
    Archivos de bronconeumologia, 2002, Volume: 38, Issue:8

    Topics: Alkyl and Aryl Transferases; Angiogenesis Inhibitors; Antineoplastic Agents; Benzamides; Benzodiazepines; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Endothelial Growth Factors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Farnesyltranstransferase; Gefitinib; Humans; Imatinib Mesylate; Imidazoles; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Lymphokines; Metalloendopeptidases; Multicenter Studies as Topic; Piperazines; Polyisoprenyl Phosphates; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Quinolones; Randomized Controlled Trials as Topic; Receptor Protein-Tyrosine Kinases; Sesquiterpenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Why the epidermal growth factor receptor? The rationale for cancer therapy.
    The oncologist, 2002, Volume: 7 Suppl 4

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Clinical Trials as Topic; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Neoplasms; Quinazolines; Signal Transduction

2002
The role of EGFR-directed therapy in the treatment of breast cancer.
    Breast cancer research and treatment, 2002, Volume: 75 Suppl 1

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Mammary Neoplasms, Experimental; Quinazolines

2002
Development of ZD1839 in colorectal cancer.
    Seminars in oncology, 2003, Volume: 30, Issue:3 Suppl 6

    Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Epidermal Growth Factor; Gefitinib; Humans; Protein-Tyrosine Kinases; Quinazolines

2003
Erlotinib: a new therapeutic approach for non-small cell lung cancer.
    Expert opinion on investigational drugs, 2003, Volume: 12, Issue:8

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Survival; Drug Screening Assays, Antitumor; Epidermal Growth Factor; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Quinazolines; Randomized Controlled Trials as Topic; Tumor Cells, Cultured

2003
[Iressa (gefitinib)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:8

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Quinazolines

2003
Growth factor receptor tyrosine kinase inhibitors; clinical development and potential for prostate cancer therapy.
    The Journal of urology, 2003, Volume: 170, Issue:6 Pt 2

    Topics: Epidermal Growth Factor; Gefitinib; Humans; Male; Prostatic Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Receptors, Growth Factor

2003
EGFR tyrosine kinase inhibitor "gefitinib (Iressa)" for cancer therapy.
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2003, Volume: 122, Issue:6

    Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Epidermal Growth Factor; Female; Gefitinib; Genes, fos; Humans; Ki-67 Antigen; Male; Middle Aged; Protein-Tyrosine Kinases; Quinazolines

2003
Biologically targeted treatment of non-small-cell lung cancer: focus on epidermal growth factor receptor.
    Clinical lung cancer, 2003, Volume: 5 Suppl 1

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Disease Progression; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Ligands; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Quinazolines

2003
Molecular targeted agents in non-small-cell lung cancer.
    Clinical lung cancer, 2003, Volume: 5 Suppl 1

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction

2003
Adjuvant systemic therapies in early-stage non-small-cell lung cancer.
    Clinical lung cancer, 2003, Volume: 5 Suppl 1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemoprevention; Chemotherapy, Adjuvant; Drug Resistance; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Neoadjuvant Therapy; Neoplasm Metastasis; Prognosis; Protein-Tyrosine Kinases; Quinazolines; Radiotherapy, Adjuvant; Selenium; Survival Analysis

2003
Primary and secondary prevention of non-small-cell lung cancer: the SPORE Trials of Lung Cancer Prevention.
    Clinical lung cancer, 2003, Volume: 5 Suppl 1

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Chemoprevention; Clinical Trials as Topic; Disease Progression; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Precancerous Conditions; Protein-Tyrosine Kinases; Quinazolines; Quinolones

2003
Inhibition of HER1 signaling pathway enhances antitumor effect of endocrine therapy in breast cancer.
    Breast cancer (Tokyo, Japan), 2004, Volume: 11, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Epidermal Growth Factor; Estradiol; Estrogen Receptor Modulators; Female; Fulvestrant; Gefitinib; Gene Expression Regulation; Genes, erbB-1; Humans; Quinazolines; Signal Transduction

2004
Gefitinib (Iressa): a novel treatment for non-small cell lung cancer.
    Expert review of anticancer therapy, 2004, Volume: 4, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Quinazolines

2004
Rationale and clinical basis for combining gefitinib (IRESSA, ZD1839) with radiation therapy for solid tumors.
    International journal of radiation oncology, biology, physics, 2004, Mar-01, Volume: 58, Issue:3

    Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Combined Modality Therapy; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Glioblastoma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Neoplasm Proteins; Neoplasms; Quinazolines; Radiation Tolerance; Radiation-Sensitizing Agents

2004
Gefitinib: phase II and III results in advanced non-small cell lung cancer.
    Seminars in oncology, 2004, Volume: 31, Issue:1 Suppl 1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Quinazolines

2004
Gefitinib, a novel, orally administered agent for the treatment of cancer.
    Journal of clinical pharmacy and therapeutics, 2004, Volume: 29, Issue:2

    Topics: Administration, Oral; Antineoplastic Agents; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Quinazolines; Survival Analysis; Treatment Outcome

2004
Estrogen receptor pathways in lung cancer.
    Current oncology reports, 2004, Volume: 6, Issue:4

    Topics: Age Factors; Animals; Antineoplastic Agents; Epidermal Growth Factor; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Gefitinib; Humans; Lung Neoplasms; Male; Quinazolines; Receptors, Estrogen; Risk Factors; Sex Distribution; Sex Factors; Signal Transduction; Smoking; Survival Rate; United States

2004
The role of gefitinib in lung cancer treatment.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jun-15, Volume: 10, Issue:12 Pt 2

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; Disease Progression; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis

2004
[Preclinical and clinical results with the epidermal growth factor receptor inhibitor Gefitinib (ZD1839, Iressa)].
    Minerva medica, 2004, Volume: 95, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Mice; Protein-Tyrosine Kinases; Quinazolines; Transplantation, Heterologous

2004
New directions in oncology nursing care: focus on gefitinib in patients with lung cancer.
    Clinical journal of oncology nursing, 2004, Volume: 8, Issue:4

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Patient Education as Topic; Protein-Tyrosine Kinases; Quinazolines

2004
Gefitinib--a novel targeted approach to treating cancer.
    Nature reviews. Cancer, 2004, Volume: 4, Issue:12

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Quinazolines

2004
[Tumor response to gefitinib (IRESSA) in pulmonary adenocarcinoma: toward a molecular basis for therapeutic targetting].
    Revue des maladies respiratoires, 2004, Volume: 21, Issue:5 Pt 1

    Topics: Adenocarcinoma; Antineoplastic Agents; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Genes, erbB-1; Humans; Lung Neoplasms; Mutation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Quinazolines

2004
Molecular changes in gliomas.
    Current opinion in oncology, 2004, Volume: 16, Issue:6

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Central Nervous System Neoplasms; Epidermal Growth Factor; Gefitinib; Glioma; Humans; Neovascularization, Pathologic; Quinazolines

2004
Combining targeted agents: blocking the epidermal growth factor and vascular endothelial growth factor pathways.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Jul-15, Volume: 12, Issue:14 Pt 2

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Synergism; Epidermal Growth Factor; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Male; Quinazolines; Vascular Endothelial Growth Factor A

2006
Dermatologic side effects associated with the epidermal growth factor receptor inhibitors.
    Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:4

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cetuximab; Drug Eruptions; Epidermal Growth Factor; Erlotinib Hydrochloride; Gefitinib; Humans; Quinazolines

2006
[Anti-EGFR therapy: towards a "à la carte" targeting of hepatocellular carcinoma].
    Gastroenterologie clinique et biologique, 2006, Volume: 30, Issue:10

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cetuximab; Clinical Trials, Phase II as Topic; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Ligands; Liver Neoplasms; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Protein Kinase Inhibitors; Quinazolines; Rats; Signal Transduction; Transforming Growth Factor alpha

2006
Her signaling in pancreatic cancer.
    Expert opinion on biological therapy, 2007, Volume: 7, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cetuximab; Deoxycytidine; Epidermal Growth Factor; Erlotinib Hydrochloride; Gemcitabine; Humans; Lapatinib; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Signal Transduction; Treatment Outcome

2007
Therapies directed against epidermal growth factor receptor in aerodigestive carcinomas.
    JAMA, 2007, Jul-04, Volume: 298, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Esophageal Neoplasms; Head and Neck Neoplasms; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Quinazolines

2007
Targeted therapy in rectal cancer.
    Oncology (Williston Park, N.Y.), 2007, Volume: 21, Issue:9

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Camptothecin; Cetuximab; Drug Delivery Systems; Epidermal Growth Factor; Erlotinib Hydrochloride; Gefitinib; Humans; Irinotecan; Neoadjuvant Therapy; Quinazolines; Rectal Neoplasms; Vascular Endothelial Growth Factor A

2007
Targeted therapy in advanced non-small-cell lung cancer.
    Seminars in respiratory and critical care medicine, 2008, Volume: 29, Issue:3

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzenesulfonates; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Drug Delivery Systems; Epidermal Growth Factor; Erlotinib Hydrochloride; Humans; Indoles; Lung Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Quinazolines; Signal Transduction; Sorafenib; Sunitinib; Treatment Outcome; Vascular Endothelial Growth Factor A

2008
The role of inhibitors of the epidermal growth factor in management of head and neck cancer.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2008, Volume: 6, Issue:7

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biomarkers, Tumor; Cetuximab; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Head and Neck Neoplasms; Humans; Panitumumab; Protein Kinase Inhibitors; Quinazolines

2008
Lapatinib and renal cell carcinoma.
    Expert opinion on investigational drugs, 2012, Volume: 21, Issue:11

    Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Epidermal Growth Factor; ErbB Receptors; Humans; Kidney Neoplasms; Lapatinib; Protein Kinase Inhibitors; Quinazolines

2012
Erlotinib : a guide to its use in first-line treatment of non-small-cell lung cancer with epidermal growth factor-activating mutations.
    Molecular diagnosis & therapy, 2013, Volume: 17, Issue:1

    Topics: Administration, Oral; Antineoplastic Agents; Asian People; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Humans; Mutation; Practice Guidelines as Topic; Protein Kinase Inhibitors; Quinazolines; Randomized Controlled Trials as Topic; White People

2013
Vandetanib for the treatment of thyroid cancer: an update.
    Expert opinion on drug metabolism & toxicology, 2014, Volume: 10, Issue:3

    Topics: Animals; Carcinoma, Neuroendocrine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Epidermal Growth Factor; Humans; Piperidines; Protein Kinase Inhibitors; Quinazolines; Randomized Controlled Trials as Topic; Thyroid Neoplasms; Transfection; Treatment Outcome; Vascular Endothelial Growth Factor Receptor-2

2014

Trials

13 trial(s) available for quinazolines and epidermal growth factor

ArticleYear
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected].
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jun-15, Volume: 21, Issue:12

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Double-Blind Method; Epidermal Growth Factor; Female; Gefitinib; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Proportional Hazards Models; Protein-Tyrosine Kinases; Quality of Life; Quinazolines; Survival Rate; Treatment Outcome

2003
Pilot trial of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib plus carboplatin and paclitaxel in patients with stage IIIB or IV non-small-cell lung cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jun-01, Volume: 21, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Paclitaxel; Pilot Projects; Protein-Tyrosine Kinases; Quinazolines; Survival Rate; United States

2003
ZD1839, a novel, oral epidermal growth factor receptor-tyrosine kinase inhibitor, as salvage treatment in patients with advanced non-small cell lung cancer. Experience from a single center participating in a compassionate use program.
    Lung cancer (Amsterdam, Netherlands), 2003, Volume: 40, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Epidermal Growth Factor; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Protein-Tyrosine Kinases; Quinazolines; Salvage Therapy; Treatment Outcome

2003
A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Cell Cycle Proteins; Cell Division; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p27; Cytoskeletal Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Gefitinib; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Ki-67 Antigen; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Time Factors; Trans-Activators; Tumor Suppressor Proteins

2003
Epidermal growth factor receptor targeted therapy by ZD 1839 (Iressa) in patients with brain metastases from non-small cell lung cancer (NSCLC).
    Lung cancer (Amsterdam, Netherlands), 2003, Volume: 41, Issue:2

    Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Epidermal Growth Factor; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Palliative Care; Quinazolines; Tomography, X-Ray Computed; Treatment Outcome

2003
Phase II trial of gefitinib in recurrent glioblastoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jan-01, Volume: 22, Issue:1

    Topics: Adult; Aged; Brain Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Female; Gefitinib; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Protein-Tyrosine Kinases; Quinazolines; Treatment Outcome

2004
Adjuvant systemic therapies in early-stage non-small-cell lung cancer.
    Clinical lung cancer, 2003, Volume: 5 Suppl 1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemoprevention; Chemotherapy, Adjuvant; Drug Resistance; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Neoadjuvant Therapy; Neoplasm Metastasis; Prognosis; Protein-Tyrosine Kinases; Quinazolines; Radiotherapy, Adjuvant; Selenium; Survival Analysis

2003
Outcomes of patients with advanced non-small cell lung cancer treated with gefitinib (ZD1839, "Iressa") on an expanded access study.
    Lung cancer (Amsterdam, Netherlands), 2004, Volume: 44, Issue:2

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Disease Progression; Epidermal Growth Factor; Female; Gefitinib; Health Status; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Protein-Tyrosine Kinases; Quinazolines; Sex Factors; Survival Analysis

2004
Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer.
    International journal of cancer, 2005, Jan-01, Volume: 113, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Disease Progression; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; Predictive Value of Tests; Quinazolines; Survival Analysis

2005
Relative bioavailability and safety profile of gefitinib administered as a tablet or as a dispersion preparation via drink or nasogastric tube: results of a randomized, open-label, three-period crossover study in healthy volunteers.
    Clinical therapeutics, 2004, Volume: 26, Issue:10

    Topics: Administration, Oral; Adult; Antineoplastic Agents; Area Under Curve; Beverages; Biological Availability; Cross-Over Studies; Epidermal Growth Factor; Gefitinib; Humans; Intubation, Gastrointestinal; Male; Middle Aged; Protein-Tyrosine Kinases; Quinazolines; Tablets

2004
Gefitinib affects functions of platelets and blood vessels via changes in prostanoids balance.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2005, Volume: 11, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Blood Vessels; Epidermal Growth Factor; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Platelet Aggregation; Prostaglandins; Quinazolines

2005
Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Sep-01, Volume: 25, Issue:25

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Adenoid Cystic; Disease-Free Survival; Epidermal Growth Factor; Female; Follow-Up Studies; Humans; Lapatinib; Male; Middle Aged; Neoplasm Recurrence, Local; Protein-Tyrosine Kinases; Quinazolines; Salivary Gland Neoplasms; Treatment Outcome

2007
Phase I trial of vandetanib and bevacizumab evaluating the VEGF and EGF signal transduction pathways in adults with solid tumours and lymphomas.
    European journal of cancer (Oxford, England : 1990), 2011, Volume: 47, Issue:7

    Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Biomarkers, Tumor; Contrast Media; Epidermal Growth Factor; Female; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasms; Piperidines; Quinazolines; Signal Transduction; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2011

Other Studies

460 other study(ies) available for quinazolines and epidermal growth factor

ArticleYear
A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.
    Science (New York, N.Y.), 1994, Aug-19, Volume: 265, Issue:5175

    Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Gene Expression; Humans; Kinetics; Mice; Mitosis; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrosine

1994
Modulation of nucleocytosolic [Ca2+] gradient in smooth muscle by protein phosphorylation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1994, Volume: 8, Issue:11

    Topics: Adenosine Triphosphate; Animals; Benzoquinones; Calcium; Cell Line; Cell Nucleus; Colforsin; Cricetinae; Cytosol; Diacylglycerol Kinase; Epidermal Growth Factor; Ethers, Cyclic; Homeostasis; Kinetics; Lactams, Macrocyclic; Leiomyosarcoma; Marine Toxins; Mesocricetus; Models, Biological; Muscle, Smooth; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Kinase C; Protein Kinases; Protein Tyrosine Phosphatases; Quinazolines; Quinazolinones; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured

1994
Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.
    Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1

    Topics: Aniline Compounds; Binding Sites; Blotting, Western; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Conformation; Molecular Structure; Phosphorylation; Protein Binding; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured

1996
Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.
    Journal of medicinal chemistry, 1996, Feb-16, Volume: 39, Issue:4

    Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Binding Sites; Carcinoma, Squamous Cell; Cell Cycle; Cell Line; DNA; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Growth Substances; Heterocyclic Compounds; Humans; Imidazoles; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Mitosis; Molecular Structure; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinazolines; Structure-Activity Relationship; Thymidine

1996
Inhibition of gastric mucosal regeneration by tyrphostin: evaluation of the role of epidermal growth factor receptor tyrosine kinase.
    The Journal of laboratory and clinical medicine, 1996, Volume: 128, Issue:2

    Topics: Animals; Benzylidene Compounds; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Male; Mucous Membrane; Nitriles; Proliferating Cell Nuclear Antigen; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Inbred F344; Regeneration; Stomach; Tyrphostins

1996
Growth inhibition of human lung adenocarcinoma cells by antibodies against epidermal growth factor receptor and by ganglioside GM3: involvement of receptor-directed protein tyrosine phosphatase(s).
    British journal of cancer, 1997, Volume: 75, Issue:2

    Topics: Adenocarcinoma; Benzylidene Compounds; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Membrane; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Humans; Lung Neoplasms; Nitriles; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Radioligand Assay; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

1997
Tyrosine kinase inhibitor-sensitive contractile action of ethanol in gastric smooth muscle: comparison with the action of epidermal growth factor.
    Proceedings of the Association of American Physicians, 1997, Volume: 109, Issue:1

    Topics: 1-Propanol; Animals; Calcium; Catechols; Cyclohexanones; Enzyme Inhibitors; Epidermal Growth Factor; Ethanol; Fomepizole; Genistein; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Indomethacin; Isoflavones; Male; Maleimides; Methanol; Muscle Contraction; Muscle, Smooth; Nitriles; Protein-Tyrosine Kinases; Pyrazoles; Quinazolines; Signal Transduction; Stomach; Tyrphostins

1997
Inhibition of tyrosine kinase activity decreases expression of surfactant protein A in a human lung adenocarcinoma cell line independent of epidermal growth factor receptor.
    Biochimica et biophysica acta, 1997, Mar-01, Volume: 1355, Issue:3

    Topics: Benzylidene Compounds; Binding, Competitive; Blotting, Northern; Blotting, Western; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Isoflavones; Lung; Lung Neoplasms; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinazolines; RNA, Messenger; Tumor Cells, Cultured; Tyrphostins

1997
Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells.
    International journal of cancer, 1997, Mar-17, Volume: 70, Issue:6

    Topics: Amphiregulin; Antineoplastic Agents; Breast Neoplasms; Cell Division; Collagenases; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gelatinases; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Neoplasm Metastasis; Quinazolines; Tumor Cells, Cultured; Up-Regulation

1997
Tyrphostin AG 494 blocks Cdk2 activation.
    FEBS letters, 1997, Jun-30, Volume: 410, Issue:2-3

    Topics: 3T3 Cells; Acrylamides; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Mice; Molecular Structure; Nitriles; Protein Serine-Threonine Kinases; Quinazolines; Tyrphostins

1997
Two- and three-dimensional cell structures govern epidermal growth factor survival function in human bladder carcinoma cell lines.
    Cancer research, 1997, Aug-15, Volume: 57, Issue:16

    Topics: Apoptosis; Culture Media, Serum-Free; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Isoflavones; Neoplasm Proteins; Nitriles; Protein-Tyrosine Kinases; Quinazolines; Spheroids, Cellular; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation; Urinary Bladder Neoplasms

1997
Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture.
    The Journal of clinical investigation, 1997, Sep-01, Volume: 100, Issue:5

    Topics: Adult; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Organ Culture Techniques; Quinazolines; Skin; Wound Healing

1997
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.
    The Biochemical journal, 1997, Oct-01, Volume: 327 ( Pt 1)

    Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Androstadienes; Aspartic Acid Endopeptidases; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Inositol; Inositol Phosphates; Maleimides; Nitriles; Phosphatidylinositols; Phosphotyrosine; Protein Kinase C; Quinazolines; Tumor Cells, Cultured; Tyrphostins; Wortmannin

1997
Role of heparin-binding EGF-related peptides in proliferation and apoptosis of activated ras-stimulated intestinal epithelial cells.
    International journal of cancer, 1997, Dec-10, Volume: 73, Issue:6

    Topics: Amphiregulin; Animals; Apoptosis; Autocrine Communication; Betacellulin; Cell Division; Cells, Cultured; Chlorates; Culture Media, Conditioned; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Nitriles; Phosphorylation; Polysaccharide-Lyases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; ras Proteins; Rats; RNA; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation

1997
EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation.
    The Journal of investigative dermatology, 1997, Volume: 109, Issue:6

    Topics: Antibodies, Monoclonal; Cell Differentiation; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Keratinocytes; Phosphorylation; Quinazolines

1997
Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:1

    Topics: Animals; Arachidonic Acid; Calcium; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Lipoprotein Lipase; Male; Mitogen-Activated Protein Kinase Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Receptors, Thrombin; Signal Transduction

1998
Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathway.
    The EMBO journal, 1998, May-01, Volume: 17, Issue:9

    Topics: Angiotensin II; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; GTP-Binding Proteins; Humans; Liver; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation

1998
Effect of tyrosine kinase inhibition on surfactant protein A gene expression during human lung development.
    The American journal of physiology, 1998, Volume: 274, Issue:4 Pt 1

    Topics: Embryonic and Fetal Development; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genistein; Homeostasis; Humans; Lung; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinazolines; RNA, Messenger; Tyrosine; Tyrphostins

1998
4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Dose-Response Relationship, Drug; Epidermal Growth Factor; Glioblastoma; Humans; Mice; Mice, SCID; Quinazolines; Transplantation, Heterologous; Tumor Cells, Cultured

1998
Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation.
    The Journal of biological chemistry, 1998, Sep-04, Volume: 273, Issue:36

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 2; GTP-Binding Proteins; Ionomycin; Models, Biological; Nitriles; PC12 Cells; Phorbol Esters; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Quinazolines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Tyrphostins; Ubiquitin-Protein Ligases; Uridine Triphosphate

1998
Epidermal growth factor (EGF) modulates fetal thymocyte growth and differentiation: partial reversal by insulin, mimicking by specific inhibitors of EGF receptor tyrosine kinase activity, and differential expression of CD45 phosphatase isotypes.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Oct-01, Volume: 161, Issue:7

    Topics: Animals; Cell Differentiation; Cell Division; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fetus; Growth Inhibitors; Immunophenotyping; Insulin; Isoenzymes; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Molecular Mimicry; Nitriles; Organ Culture Techniques; Quinazolines; Solubility; T-Lymphocyte Subsets; Thymus Gland; Tyrphostins

1998
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells.
    International journal of cancer, 1998, Oct-29, Volume: 78, Issue:3

    Topics: Acute-Phase Proteins; Animals; bcl-X Protein; Cell Line; Cell Survival; Cell Transformation, Neoplastic; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Intestinal Mucosa; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Rats; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrphostins

1998
Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154).
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:10

    Topics: Actins; Antineoplastic Agents; Cell Adhesion; Epidermal Growth Factor; Glioblastoma; Humans; Integrins; Neoplasm Invasiveness; Quinazolines; Tumor Cells, Cultured

1998
Bunazosin hydrochloride inhibits exaggerated growth of vascular smooth muscle cells from spontaneously hypertensive rats by suppressing the response to growth factors.
    Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:6

    Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; Growth Inhibitors; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Quinazolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger

1998
Chronic ethanol consumption disrupts complexation between EGF receptor and phospholipase C-gamma1: relevance to impaired hepatocyte proliferation.
    Biochemical and biophysical research communications, 1999, Apr-02, Volume: 257, Issue:1

    Topics: Animals; Calcium Signaling; Cell Division; Cells, Cultured; Cytoskeleton; Cytosol; DNA; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Ethanol; Isoenzymes; Liver; Male; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; Quinazolines; Rats; Rats, Wistar; Type C Phospholipases; Tyrphostins

1999
Involvement of tyrosine kinases on cyclooxygenase expression and prostaglandin E2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor.
    Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2

    Topics: Benzoquinones; Cells, Cultured; Child; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Interleukin-1; Isoenzymes; Lactams, Macrocyclic; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Quinazolines; Quinones; Rifabutin; RNA, Messenger; Sulfonamides; Time Factors

1999
Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells.
    Biochemical and biophysical research communications, 1999, Jul-14, Volume: 260, Issue:3

    Topics: Adenocarcinoma; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

1999
In vitro modulation of cyst formation by a novel tyrosine kinase inhibitor.
    Kidney international, 1999, Volume: 56, Issue:2

    Topics: Animals; Cell Division; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Kidney Tubules, Collecting; Mice; Mice, Mutant Strains; Nephrons; Organ Culture Techniques; Phosphorylation; Polycystic Kidney Diseases; Protein-Tyrosine Kinases; Quinazolines

1999
Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling.
    The Journal of cell biology, 1999, Aug-23, Volume: 146, Issue:4

    Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Chromones; Cytochalasin D; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mice; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Quinazolines; Receptor, ErbB-3; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Transfection; Tyrphostins

1999
A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:8

    Topics: Adenocarcinoma; Animals; Autocrine Communication; Breast Neoplasms; Cell Line; Diffusion Chambers, Culture; Epidermal Growth Factor; ErbB Receptors; Estrenes; Female; Humans; Immunoblotting; Isoenzymes; Male; Mice; Neoplasm Invasiveness; Phosphodiesterase Inhibitors; Phospholipase C gamma; Phosphorylation; Prostatic Neoplasms; Pyrrolidinones; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Type C Phospholipases

1999
Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Animals; Cell Division; Cell Line, Transformed; Chemotaxis; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Matrix; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Genistein; Growth Substances; Hepatocyte Growth Factor; Insulin-Like Growth Factor I; Intestines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Quinazolines; Transforming Growth Factor beta; Type C Phospholipases; Tyrphostins

1999
Fluid flow-induced tyrosine phosphorylation and participation of growth factor signaling pathway in osteoblast-like cells.
    Journal of cellular biochemistry, 2000, Volume: 76, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Blotting, Western; Cell Line; Culture Media; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; Gene Expression Regulation; Immediate-Early Proteins; Mice; Mitogen-Activated Protein Kinase 1; Osteoblasts; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Quinazolines; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Stress, Mechanical; Transcription Factors; Tyrosine; Tyrphostins

2000
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-15, Volume: 97, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clathrin; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; GTP-Binding Proteins; Isoproterenol; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Cell Surface; Transfection; Tyrphostins

2000
Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines.
    The Journal of urology, 2000, Volume: 163, Issue:3

    Topics: Cell Division; Dihydrotestosterone; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2000
The mitogen-activated protein kinase cascade mediates neurotrophic effect of epidermal growth factor in cultured rat hippocampal neurons.
    Neuroscience letters, 2000, Mar-17, Volume: 282, Issue:1-2

    Topics: Animals; Blotting, Western; Butadienes; Cell Survival; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hippocampus; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Tyrphostins

2000
Calcium channel antagonist effect on in vitro meningioma signal transduction pathways after growth factor stimulation.
    Neurosurgery, 2000, Volume: 46, Issue:3

    Topics: Adult; Aged; Blood Physiological Phenomena; Calcium; Calcium Channel Blockers; Culture Techniques; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Growth Substances; Humans; Inositol Phosphates; Intracellular Membranes; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Quinazolines; Signal Transduction; Type C Phospholipases; Tyrphostins

2000
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.
    The Journal of biological chemistry, 2000, Mar-24, Volume: 275, Issue:12

    Topics: Animals; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-met; Quinazolines; Rats; Receptor Cross-Talk; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2000
Use of epidermal growth factor and collagen synthesis inhibition as adjuvant to healing of ureteroureteral anastomosis.
    Journal of endourology, 2000, Volume: 14, Issue:2

    Topics: Adjuvants, Pharmaceutic; Anastomosis, Surgical; Animals; Collagen; Drug Evaluation; Epidermal Growth Factor; Female; Piperidines; Quinazolines; Quinazolinones; Random Allocation; Swine; Ureter; Wound Healing

2000
Peroxynitrite modulates the activation of p38 and extracellular regulated kinases in PC12 cells.
    Archives of biochemistry and biophysics, 2000, Apr-15, Volume: 376, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Nitrates; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Quinazolines; Rats; src-Family Kinases; Tyrphostins

2000
Role of basal calcium in the EGF activation of MAP kinases.
    Oncogene, 2000, Mar-30, Volume: 19, Issue:14

    Topics: Animals; Calcium; Cell Line; Chelating Agents; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Isoenzymes; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipase C gamma; Protein Tyrosine Phosphatases; Quinazolines; Type C Phospholipases; Tyrphostins

2000
Activation of epidermal growth factor receptor during corneal epithelial migration.
    Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:6

    Topics: Amphiregulin; Animals; Binding Sites; Cell Movement; Debridement; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium, Corneal; ErbB Receptors; Female; Fluorescent Antibody Technique, Indirect; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Organ Culture Techniques; Phosphorylation; Precipitin Tests; Quinazolines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrphostins; Wound Healing

2000
Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor.
    Circulation research, 2000, Jul-21, Volume: 87, Issue:2

    Topics: Animals; Anticoagulants; Aorta; Becaplermin; Cell Line; Cell Movement; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Papio; Phenylalanine; Phosphorylation; Platelet-Derived Growth Factor; Protease Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Rats; Rats, Inbred F344; Signal Transduction; Thiophenes; Thrombin; Tyrphostins

2000
Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells.
    Cancer research, 2000, Jul-01, Volume: 60, Issue:13

    Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; Female; HL-60 Cells; Humans; Microtubules; Mitosis; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Tyrphostins

2000
Cross-talk between receptors with intrinsic tyrosine kinase activity and alpha1b-adrenoceptors.
    The Biochemical journal, 2000, Sep-01, Volume: 350 Pt 2

    Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Cell Line; Cell Membrane; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Norepinephrine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; Staurosporine; Time Factors; Transfection; Tyrphostins; Wortmannin

2000
Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells.
    Cancer research, 2000, Sep-15, Volume: 60, Issue:18

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Division; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; GRB2 Adaptor Protein; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Ovarian Neoplasms; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proteins; Quinazolines; Receptor, Endothelin A; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine; Tyrphostins

2000
Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.
    Oncogene, 2000, Sep-21, Volume: 19, Issue:40

    Topics: Alkaline Phosphatase; Biological Transport; Breast Neoplasms; Cell Nucleus; Chromones; Cytoplasm; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Macromolecular Substances; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Quinazolines; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Tyrphostins; Ubiquitin-Protein Ligases

2000
Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression.
    Carcinogenesis, 2000, Volume: 21, Issue:12

    Topics: Amphiregulin; Animals; Betacellulin; Butylhydroxybutylnitrosamine; Carcinogens; Disease Progression; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Tyrphostins

2000
Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation.
    Circulation research, 2001, Jan-19, Volume: 88, Issue:1

    Topics: Angiopoietin-1; Angiopoietin-2; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Cells, Cultured; Cornea; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Imidazoles; In Vitro Techniques; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Maleimides; Membrane Glycoproteins; Naphthalenes; Neovascularization, Physiologic; Olmesartan Medoxomil; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proteins; Pyridines; Quinazolines; Rabbits; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, TIE-2; Receptors, Angiotensin; Receptors, Cell Surface; Receptors, TIE; RNA Stability; RNA, Messenger; Tetrazoles; Time Factors; Transcriptional Activation; Tyrphostins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2001
Activation of endogenous thrombin receptors causes clustering and sensitization of epidermal growth factor receptors of swiss 3T3 cells without transactivation.
    The Journal of cell biology, 2001, Jan-22, Volume: 152, Issue:2

    Topics: 3T3 Cells; Animals; Cell Division; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; GTP-Binding Proteins; Luminescent Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phalloidine; Quinazolines; Receptor Cross-Talk; Receptors, Thrombin; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Thrombin; Transfection; Tyrphostins

2001
Epidermal growth factor induction of apolipoprotein A-I is mediated by the Ras-MAP kinase cascade and Sp1.
    The Journal of biological chemistry, 2001, Apr-27, Volume: 276, Issue:17

    Topics: Amino Acid Sequence; Apolipoprotein A-I; Binding Sites; Blotting, Western; Chloramphenicol O-Acetyltransferase; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genes, Dominant; Genes, ras; Genes, Reporter; Humans; Insulin; MAP Kinase Signaling System; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Protein Synthesis Inhibitors; Quinazolines; ras Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sp1 Transcription Factor; Threonine; Time Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Up-Regulation

2001
Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.
    British journal of cancer, 2001, Apr-06, Volume: 84, Issue:7

    Topics: Cell Division; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gastrin-Releasing Peptide; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Quinazolines; Substrate Specificity; Transcription Factor AP-1; Tumor Cells, Cultured; Tyrphostins

2001
Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.
    Molecular biology of the cell, 2001, Volume: 12, Issue:5

    Topics: bcl-X Protein; Calcium-Calmodulin-Dependent Protein Kinases; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Flavonoids; Humans; In Situ Nick-End Labeling; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tyrphostins

2001
Fatty acids inhibit growth-factor-induced diacylglycerol kinase alpha activation in vascular smooth-muscle cells.
    The Biochemical journal, 2001, Jul-01, Volume: 357, Issue:Pt 1

    Topics: Animals; Carotid Arteries; Cell Membrane; Cells, Cultured; Cytosol; Diacylglycerol Kinase; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Escherichia coli; Fatty Acids, Nonesterified; Isoenzymes; Kinetics; Muscle, Smooth, Vascular; Oleic Acid; Palmitic Acid; Piperidines; Platelet-Derived Growth Factor; Quinazolines; Quinazolinones; Recombinant Proteins; Swine; Thrombin

2001
Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.
    Cancer research, 2001, Aug-01, Volume: 61, Issue:15

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Kinetics; Ligands; Lung Neoplasms; Mammary Neoplasms, Experimental; Phthalimides; Quinazolines; Rats; Signal Transduction; Tumor Cells, Cultured

2001
Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.
    European journal of biochemistry, 2001, Volume: 268, Issue:15

    Topics: Androstadienes; Animals; Cell-Free System; CHO Cells; Cricetinae; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Quinazolines; Receptor, Insulin; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Wortmannin

2001
ZD-1839 (AstraZeneca).
    Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:3

    Topics: Anemia; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Diarrhea; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Tolerance; Drugs, Investigational; Economics, Pharmaceutical; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Nausea; Pancreatic Neoplasms; Quinazolines; Tumor Cells, Cultured

2001
Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands.
    The Journal of biological chemistry, 2002, Jan-04, Volume: 277, Issue:1

    Topics: Antigens, CD; Cell Adhesion; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix Proteins; Humans; Integrin alpha2; Ligands; Quinazolines; RNA, Messenger; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2002
Lymnaea epidermal growth factor promotes axonal regeneration in CNS organ culture.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Dec-01, Volume: 21, Issue:23

    Topics: Animals; Axons; Carbazoles; Central Nervous System; Disease Models, Animal; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Indole Alkaloids; Lymnaea; Nerve Crush; Nerve Regeneration; Neurons; Organ Culture Techniques; Quinazolines; Reproducibility of Results

2001
ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression.
    International journal of cancer, 2001, Dec-15, Volume: 94, Issue:6

    Topics: Cell Division; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Genes, erbB-2; Humans; Mitogen-Activated Protein Kinases; Neoplasms, Experimental; Phosphorylation; Quinazolines; Tumor Cells, Cultured

2001
The role of Ral A in epidermal growth factor receptor-regulated cell motility.
    Cancer research, 2002, Feb-15, Volume: 62, Issue:4

    Topics: Animals; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Neoplasm Metastasis; Quinazolines; ral GTP-Binding Proteins; Tumor Cells, Cultured; Tyrphostins; Urinary Bladder Neoplasms

2002
Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes.
    Molecular endocrinology (Baltimore, Md.), 2002, Volume: 16, Issue:3

    Topics: Angiotensin II; Animals; Arsenicals; Cell Line; Concanavalin A; COS Cells; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Hepatocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Quinazolines; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sucrose; Transfection; Tyrphostins

2002
Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts.
    The Journal of biological chemistry, 2002, May-24, Volume: 277, Issue:21

    Topics: Animals; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Leukocyte Elastase; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Tropoelastin; Tyrphostins

2002
ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase.
    Cancer research, 2002, May-01, Volume: 62, Issue:9

    Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Squamous Cell; Cell Movement; Cells, Cultured; Cornea; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Interleukin-8; Lymphokines; Male; Mitogen-Activated Protein Kinase Kinases; Neovascularization, Physiologic; Quinazolines; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vulvar Neoplasms

2002
Targeting the epidermal growth factor receptor with tyrosine kinase inhibitors: small molecules, big hopes.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, May-01, Volume: 20, Issue:9

    Topics: Administration, Oral; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Neoplasms; Protein-Tyrosine Kinases; Quinazolines

2002
Multiple responses to EGF receptor activation and their abrogation by a specific EGF receptor tyrosine kinase inhibitor.
    The Prostate, 2002, Jun-01, Volume: 52, Issue:1

    Topics: Adenocarcinoma; Apoptosis; Blotting, Northern; Blotting, Western; Cell Count; Cell Cycle; Cell Division; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Immunohistochemistry; Male; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Phosphorylation; Prostatic Neoplasms; Quinazolines; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured

2002
Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor.
    The Journal of biological chemistry, 2002, Aug-02, Volume: 277, Issue:31

    Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Female; Gefitinib; Insulin-Like Growth Factor I; Mammary Glands, Animal; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Mice, Knockout; Phosphatidylinositol 3-Kinases; Pregnancy; Quinazolines; Receptors, Somatomedin; Signal Transduction; Transcriptional Activation

2002
Ex vivo stimulation of renal transport of the cytostatic drugs methotrexate, cisplatin, topotecan (Hycamtin) and raltitrexed (Tomudex) by dexamethasone, T3 and EGF in intact human and rat kidney tissue and in human renal cell carcinoma.
    Urological research, 2002, Volume: 30, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Carcinoma, Renal Cell; Cisplatin; Dexamethasone; Epidermal Growth Factor; Female; Glucocorticoids; Humans; Kidney; Kidney Neoplasms; Methotrexate; Quinazolines; Rats; Rats, Wistar; Thiophenes; Topotecan; Triiodothyronine

2002
Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways.
    Oncogene, 2002, Sep-12, Volume: 21, Issue:41

    Topics: Antineoplastic Agents; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Lapatinib; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured

2002
Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:4

    Topics: Animals; CDX2 Transcription Factor; Cell Division; Cell Line; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Homeodomain Proteins; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Male; Mice; Promoter Regions, Genetic; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Transcription, Genetic; Transfection

2002
Secretin regulates paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:4

    Topics: Animals; Cell Membrane Permeability; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Electric Impedance; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Gastric Mucosa; Mannitol; Parietal Cells, Gastric; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinazolines; Secretin; src-Family Kinases; Tyrphostins

2002
Inhibition of epidermal growth factor receptor signaling in malignant pleural mesothelioma.
    Cancer research, 2002, Sep-15, Volume: 62, Issue:18

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Division; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mesothelioma; Phosphorylation; Pleural Neoplasms; Quinazolines; Signal Transduction; Tumor Cells, Cultured

2002
Surprise phase III failure for ZD1839.
    The Lancet. Oncology, 2002, Volume: 3, Issue:10

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cisplatin; Clinical Trials, Phase III as Topic; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Quality of Life; Quinazolines; Survival Analysis; Treatment Outcome

2002
Cancer drugs. Smart weapons prove tough to design.
    Science (New York, N.Y.), 2002, Oct-18, Volume: 298, Issue:5593

    Topics: Advisory Committees; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Drug Approval; Drug Industry; Epidermal Growth Factor; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Lung Neoplasms; Neoplasms; Patient Selection; Piperazines; Pyrimidines; Quinazolines; United States; United States Food and Drug Administration

2002
Relationship of EGFR signal-transduction modulation by tyrosine kinase inhibitors to chemosensitivity and programmed cell death in lung cancer cell lines.
    Methods in molecular medicine, 2003, Volume: 74

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Lung Neoplasms; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2003
The simpleton's error in drug development.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Dec-01, Volume: 20, Issue:23

    Topics: Antineoplastic Agents; Clinical Trials, Phase II as Topic; Drug Design; Drugs, Investigational; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Protein-Tyrosine Kinases; Quinazolines; Randomized Controlled Trials as Topic

2002
The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.
    Molecular cancer therapeutics, 2001, Volume: 1, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Fibroblasts; Furans; Humans; Infant, Newborn; Mice; Mice, Nude; Mice, SCID; Neoplasms, Experimental; Phosphorylation; Precipitin Tests; Quinazolines; Receptor, ErbB-2; Signal Transduction; Skin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2001
Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells.
    Cell and tissue research, 2003, Volume: 311, Issue:1

    Topics: Animals; Anisomycin; Antibody Specificity; Cell Membrane; Cells, Cultured; Connexin 43; Cytoplasm; Diuretics, Osmotic; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Fluorescent Antibody Technique; Liver; Microscopy, Confocal; Osmotic Pressure; Phosphorylation; Protein Synthesis Inhibitors; Quinazolines; Rabbits; Rats; Sorbitol; Tyrphostins

2003
Differential responses of EGFR-/AGT-expressing cells to the "combi-triazene" SMA41.
    Cancer chemotherapy and pharmacology, 2003, Volume: 51, Issue:1

    Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Cycle; Cell Division; DNA Damage; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; O(6)-Methylguanine-DNA Methyltransferase; Quinazolines; Tumor Cells, Cultured

2003
Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb.
    American journal of physiology. Cell physiology, 2003, Volume: 284, Issue:5

    Topics: Base Sequence; Blotting, Western; Caco-2 Cells; DNA; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myb; Quinazolines; Signal Transduction; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type IIb; Symporters; Transcription, Genetic; Tyrphostins

2003
BAD: a good therapeutic target?
    Breast cancer research : BCR, 2003, Volume: 5, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Breast Neoplasms; Carrier Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured

2003
EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. Epidermal growth factor receptor.
    International journal of radiation oncology, biology, physics, 2003, Mar-01, Volume: 55, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Division; Drug Screening Assays, Antitumor; Endothelial Growth Factors; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mice, Nude; Phosphorylation; Quinazolines; Radiation-Sensitizing Agents; Radiotherapy Dosage; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Necrolytic migratory erythema (glucagenoma)-like skin lesions induced by EGF-receptor inhibition.
    Swiss medical weekly, 2003, Jan-11, Volume: 133, Issue:1-2

    Topics: Carcinoma, Non-Small-Cell Lung; Epidermal Growth Factor; Erythema; Female; Gefitinib; Humans; Lung Neoplasms; Middle Aged; Protein-Tyrosine Kinases; Quinazolines

2003
Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland.
    Investigative ophthalmology & visual science, 2003, Volume: 44, Issue:3

    Topics: Animals; Blotting, Western; Calcium; Carbachol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Eye Proteins; Lacrimal Apparatus; Male; Peroxidase; Phenylephrine; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrphostins

2003
P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation.
    Investigative ophthalmology & visual science, 2003, Volume: 44, Issue:3

    Topics: Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Cell Division; Cells, Cultured; DNA; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Quinazolines; Receptors, Platelet-Derived Growth Factor; Receptors, Purinergic P2; Tyrphostins

2003
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling.
    Radiation research, 2003, Volume: 159, Issue:4

    Topics: Adenocarcinoma; Autocrine Communication; Cobalt Radioisotopes; DNA Damage; DNA Repair; DNA-Binding Proteins; Endonucleases; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Prostatic Neoplasms; Protein Biosynthesis; Proteins; Quinazolines; Tumor Cells, Cultured; Tyrphostins; X-ray Repair Cross Complementing Protein 1

2003
Dramatic effect of ZD1839 ('Iressa') in a patient with advanced non-small-cell lung cancer and poor performance status.
    Lung cancer (Amsterdam, Netherlands), 2003, Volume: 40, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Docetaxel; Enzyme Inhibitors; Epidermal Growth Factor; Female; Gefitinib; Humans; Irinotecan; Lung Neoplasms; Middle Aged; Neoplasm Staging; Paclitaxel; Protein-Tyrosine Kinases; Quinazolines; Salvage Therapy; Taxoids; Treatment Outcome

2003
[14th EORTC-NCI-AAACR Symposium on New Molecular Targets and Cancer Therapeutics].
    Bulletin du cancer, 2003, Volume: 90, Issue:2

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Epidermal Growth Factor; Gefitinib; Germany; Lung Neoplasms; Protein-Tyrosine Kinases; Quinazolines

2003
Activated epidermal growth factor receptor (ErbB1) protects the heart against stress-induced injury in mice.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 285, Issue:2

    Topics: Aggression; Animals; Behavior, Animal; Cold Temperature; Epidermal Growth Factor; ErbB Receptors; Heart; Male; Mice; Myocardium; Quinazolines; Restraint, Physical; Stress, Physiological; Tyrphostins

2003
Prostate cancer cell proliferation is strongly reduced by the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in vitro on human cell lines and primary cultures.
    Journal of cancer research and clinical oncology, 2003, Volume: 129, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; In Vitro Techniques; Male; Phosphorylation; Prostatic Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrosine

2003
Epidermal growth factor as a biologic switch in hair growth cycle.
    The Journal of biological chemistry, 2003, Jul-11, Volume: 278, Issue:28

    Topics: Animals; Cell Division; Dimerization; Epidermal Growth Factor; Hair; Hair Follicle; Heterozygote; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Phenotype; Phosphorylation; Precipitin Tests; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin Physiological Phenomena; Time Factors; Tyrphostins

2003
Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
    Molecular endocrinology (Baltimore, Md.), 2003, Volume: 17, Issue:8

    Topics: Animals; Cell Differentiation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dinoprost; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Lysophospholipids; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; Parathyroid Hormone; Phosphorylation; Protein Kinase C; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Receptors, Prostaglandin; Signal Transduction; Transcriptional Activation; Tyrphostins

2003
Treatment of cultured glioma cells with the EGFR-TKI gefitinib ("Iressa", ZD1839) increases the uptake of astatinated EGF despite the absence of gefitinib-mediated growth inhibition.
    European journal of nuclear medicine and molecular imaging, 2003, Volume: 30, Issue:5

    Topics: Astatine; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Glioma; Humans; Metabolic Clearance Rate; Protein-Tyrosine Kinases; Quinazolines; Radioisotopes; Radiopharmaceuticals

2003
Gefitinib in recurrent non-small-cell lung cancer: an IDEAL trial?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jun-15, Volume: 21, Issue:12

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase II as Topic; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Quinazolines; Randomized Controlled Trials as Topic; Survival Rate

2003
Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells.
    Investigative ophthalmology & visual science, 2003, Volume: 44, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Carbachol; Cells, Cultured; Cholinergic Agonists; Conjunctiva; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Goblet Cells; Humans; Male; Middle Aged; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Piperidines; Quinazolines; Rats; Rats, Sprague-Dawley; Time Factors; Tyrphostins

2003
Diffuse alveolar damage after ZD1839 therapy in a patient with non-small cell lung cancer.
    Lung cancer (Amsterdam, Netherlands), 2003, Volume: 40, Issue:3

    Topics: Administration, Oral; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Epidermal Growth Factor; Fatal Outcome; Gefitinib; Humans; Lung Neoplasms; Male; Protein-Tyrosine Kinases; Pulmonary Alveoli; Quinazolines

2003
Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
    International journal of cancer, 2003, Aug-10, Volume: 106, Issue:1

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Cell Division; Cell Separation; Ceramides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Male; Membrane Potentials; Mitochondria; Necrosis; Prostatic Neoplasms; Protease Inhibitors; Quinazolines; Tumor Cells, Cultured

2003
A report of two bronchioloalveolar carcinoma cases which were rapidly improved by treatment with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 ("Iressa").
    Cancer science, 2003, Volume: 94, Issue:5

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Aged; Antineoplastic Agents; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Hypoxia; Lung Neoplasms; Middle Aged; Quinazolines; Radiography; Sputum

2003
Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells.
    Experimental cell research, 2003, Jul-15, Volume: 287, Issue:2

    Topics: Animals; Apoptosis; bcl-X Protein; Butadienes; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Quinazolines; Up-Regulation

2003
Wound healing is not impaired by the epidermal growth factor receptor-tyrosine kinase inhibitor gefitinib.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:8

    Topics: Administration, Oral; Aged; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Epidermal Growth Factor; Female; Follow-Up Studies; Gefitinib; Humans; Lung Neoplasms; Male; Pneumonectomy; Postoperative Care; Quinazolines; Risk Assessment; Sampling Studies; Wound Healing

2003
Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells.
    Oncogene, 2003, Jul-17, Volume: 22, Issue:29

    Topics: Amphiregulin; Animals; Cells, Cultured; Colonic Neoplasms; Dogs; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Genes, src; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Kidney; Mucins; Muscle Proteins; Mutation; Neoplasm Invasiveness; Neuropeptides; Peptides; Phosphatidylinositol 3-Kinases; Proteins; Quinazolines; Receptors, Thromboxane; Signal Transduction; Transforming Growth Factor alpha; Trefoil Factor-1; Trefoil Factor-2; Trefoil Factor-3; Tumor Suppressor Proteins

2003
Molecular mechanisms underlying the interaction between ZD1839 ('Iressa') and cisplatin/5-fluorouracil.
    British journal of cancer, 2003, Aug-04, Volume: 89, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cisplatin; DNA Repair; Drug Interactions; Epidermal Growth Factor; ErbB Receptors; Fluorouracil; Gefitinib; Head and Neck Neoplasms; Humans; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Tumor Cells, Cultured

2003
In regard to Solomon et al.: EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. IJROBP 2003;55:713-723.
    International journal of radiation oncology, biology, physics, 2003, Sep-01, Volume: 57, Issue:1

    Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Division; Dose Fractionation, Radiation; Endothelial Growth Factors; Epidermal Growth Factor; Female; Mice; Mice, Nude; Quinazolines; Radiation-Sensitizing Agents; Radiotherapy Dosage; Tumor Cells, Cultured

2003
Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with 211At-EGF.
    European journal of nuclear medicine and molecular imaging, 2003, Volume: 30, Issue:10

    Topics: Antineoplastic Agents; Astatine; Astrocytoma; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Epidermal Growth Factor; Gefitinib; Humans; Quinazolines; Radiopharmaceuticals; Treatment Outcome

2003
EGFRvIII-mediated radioresistance through a strong cytoprotective response.
    Oncogene, 2003, Aug-28, Volume: 22, Issue:36

    Topics: Animals; Apoptosis; CHO Cells; Cricetinae; Cytoprotection; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Radiation Tolerance; Tyrphostins

2003
The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro.
    Endocrinology, 2003, Volume: 144, Issue:11

    Topics: Antineoplastic Agents, Hormonal; Apoptosis; Breast Neoplasms; Cell Division; Cell Line, Tumor; Drug Combinations; Drug Resistance; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Gefitinib; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tamoxifen

2003
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.
    American journal of respiratory cell and molecular biology, 2004, Volume: 30, Issue:4

    Topics: Antibodies; Bronchi; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Matrix Metalloproteinase Inhibitors; Phosphorylation; Quinazolines; Tyrosine; Zinc

2004
Epidermal growth factor receptor regulates normal urothelial regeneration.
    Laboratory investigation; a journal of technical methods and pathology, 2003, Volume: 83, Issue:9

    Topics: Amphiregulin; Antibodies, Blocking; Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Movement; Cells, Cultured; DNA Primers; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Quinazolines; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transforming Growth Factor alpha; Tyrphostins; Urothelium; Wound Healing

2003
Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor.
    Experimental cell research, 2003, Oct-01, Volume: 289, Issue:2

    Topics: 3T3 Cells; Animals; Cell Communication; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Hepatocyte Growth Factor; Humans; Kidney; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins; Quinazolines; Receptor Cross-Talk; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrphostins

2003
The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status.
    Lung cancer (Amsterdam, Netherlands), 2003, Volume: 42, Issue:1

    Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Genes, ras; Humans; Lung Neoplasms; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Tumor Cells, Cultured

2003
Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway.
    The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52

    Topics: Animals; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Cycle Proteins; Cell Division; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Male; MAP Kinase Signaling System; Microscopy, Confocal; Muscle, Smooth, Vascular; Phenotype; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; S Phase; Time Factors; Tumor Suppressor Proteins; Tyrphostins

2003
Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-01, Volume: 9, Issue:12

    Topics: Breast Neoplasms; Chromones; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; Female; Gefitinib; Genes, Tumor Suppressor; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transfection; Tumor Cells, Cultured

2003
Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.
    Cellular signalling, 2003, Volume: 15, Issue:12

    Topics: Androstadienes; Animals; Carbachol; cdc42 GTP-Binding Protein; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Kinetics; Lysophospholipids; Maleimides; Mice; Models, Biological; Myelin Basic Protein; NIH 3T3 Cells; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Quinazolines; rac GTP-Binding Proteins; ras Proteins; Receptor, Muscarinic M2; Receptors, Cell Surface; rho GTP-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrphostins; Wortmannin

2003
Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') is independent of EGFR expression level.
    Journal of cellular physiology, 2004, Volume: 198, Issue:2

    Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Division; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Flow Cytometry; Gefitinib; Humans; Mitogen-Activated Protein Kinases; Precipitin Tests; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2

2004
Time and dose-dependent radiosensitization of the glioblastoma multiforme U251 cells by the EGF receptor tyrosine kinase inhibitor ZD1839 ('Iressa').
    Cancer letters, 2003, Dec-08, Volume: 202, Issue:1

    Topics: Antineoplastic Agents; Brain Neoplasms; Cell Division; Cerebellum; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Phosphorylation; Placenta; Quinazolines; Radiation-Sensitizing Agents; Radiation, Ionizing; Radiotherapy Dosage; Time Factors; Tumor Cells, Cultured; Tumor Stem Cell Assay

2003
Activity of a specific inhibitor, gefitinib (Iressa, ZD1839), of epidermal growth factor receptor in refractory non-small-cell lung cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Disease Progression; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Protein-Tyrosine Kinases; Quinazolines; Survival Analysis

2004
Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells.
    The Journal of investigative dermatology, 2003, Volume: 121, Issue:5

    Topics: Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphoproteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Quinazolines; Repressor Proteins; RNA, Messenger; Skin Neoplasms; Telomerase; Transforming Growth Factor alpha; Tyrphostins

2003
Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells.
    British journal of cancer, 2004, Jan-12, Volume: 90, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Epidermal Growth Factor; Estradiol; Estrogen Receptor Modulators; Female; Fulvestrant; Gefitinib; Humans; Protein-Tyrosine Kinases; Quinazolines; Receptors, Estrogen; Signal Transduction; Tumor Cells, Cultured

2004
EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases.
    Experimental cell research, 2004, Jan-01, Volume: 292, Issue:1

    Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Female; Genes, src; Humans; Kinetics; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Peptide Fragments; Phosphorylation; Quinazolines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Transcriptional Activation; Tyrphostins; Urokinase-Type Plasminogen Activator

2004
The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jan-15, Volume: 10, Issue:2

    Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Survival; CSK Tyrosine-Protein Kinase; Cytoskeleton; Disease Progression; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Head and Neck Neoplasms; Humans; Microscopy, Fluorescence; Neoplasm Invasiveness; p21-Activated Kinases; Phenotype; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; src-Family Kinases; Transfection; Vinculin

2004
Response to gefitinib in pericardial effusion due to lung cancer.
    Acta medica (Hradec Kralove), 2003, Volume: 46, Issue:4

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Epidermal Growth Factor; Female; Gefitinib; Humans; Lung Neoplasms; Pericardial Effusion; Protein-Tyrosine Kinases; Quinazolines

2003
Lung cancer: looking ahead in 2004.
    Clinical lung cancer, 2004, Volume: 5, Issue:4

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Quinazolines

2004
The combi-targetinG concept: intracellular fragmentation of the binary epidermal growth factor (EGFR)/DNA targeting "combi-triazene" SMA41.
    Biochemical pharmacology, 2004, Mar-15, Volume: 67, Issue:6

    Topics: Cell Division; DNA; Epidermal Growth Factor; Flow Cytometry; Fluorometry; Humans; Hydrolysis; Microscopy, Fluorescence; Quinazolines; RNA; Tumor Cells, Cultured; Ultraviolet Rays

2004
Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Mar-15, Volume: 22, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bronchoalveolar Lavage Fluid; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Epidermal Growth Factor; Female; Gefitinib; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Protein-Tyrosine Kinases; Quinazolines; Retrospective Studies; Smoking

2004
Cutaneous side effects in non-small cell lung cancer patients treated with Iressa (ZD1839), an inhibitor of epidermal growth factor.
    Acta dermato-venereologica, 2004, Volume: 84, Issue:1

    Topics: Acneiform Eruptions; Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Epidermal Growth Factor; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Paronychia; Quinazolines; Retrospective Studies; Signal Transduction; Skin; Urticaria

2004
Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme.
    Journal of cell science, 2004, Apr-15, Volume: 117, Issue:Pt 10

    Topics: Active Transport, Cell Nucleus; Adipocytes; Anilides; Animals; Blotting, Western; Cattle; Cell Differentiation; Cell Line; Cell Proliferation; Chromans; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Gene Expression Regulation; Humans; Immunoprecipitation; Ligands; Membrane Glycoproteins; Membrane Proteins; Microscopy, Fluorescence; Phosphorylation; PPAR gamma; Promoter Regions, Genetic; Quinazolines; Ribonucleases; RNA, Messenger; Signal Transduction; Thiazolidinediones; Time Factors; Troglitazone; Uroplakin Ia; Uroplakin Ib; Uroplakin II; Uroplakin III; Urothelium

2004
Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes.
    The Journal of endocrinology, 2004, Volume: 181, Issue:1

    Topics: Adult; Amphiregulin; Antibodies, Monoclonal; Bacterial Proteins; Cell Division; Cells, Cultured; Dactinomycin; EGF Family of Proteins; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression Regulation; Genes, erbB-1; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Infant, Newborn; Intercellular Signaling Peptides and Proteins; Keratinocytes; Parathyroid Hormone-Related Protein; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha

2004
Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:4

    Topics: Antibodies, Monoclonal; Cell Division; Cell Line, Tumor; DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Inhibitory Concentration 50; Phosphorylation; Quinazolines; Receptor, ErbB-2; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrphostins

2004
Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:4

    Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Cell Survival; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Ubiquitin-Protein Ligases

2004
Gefitinib ('Iressa', ZD1839) inhibits the growth response of bladder tumour cell lines to epidermal growth factor and induces TIMP2.
    British journal of cancer, 2004, Apr-19, Volume: 90, Issue:8

    Topics: Antineoplastic Agents; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Protease Inhibitors; Quinazolines; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2004
Gefitinib for advanced or metastatic non-small cell lung cancer.
    Issues in emerging health technologies, 2004, Issue:55

    Topics: Antineoplastic Agents; Australia; Canada; Carcinoma, Non-Small-Cell Lung; Drug Approval; Drug Costs; Epidermal Growth Factor; Humans; Japan; Lung Neoplasms; Neoplasm Staging; Protein-Tyrosine Kinases; Quinazolines; Randomized Controlled Trials as Topic; Treatment Outcome; United States

2004
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
    The New England journal of medicine, 2004, May-20, Volume: 350, Issue:21

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Antineoplastic Agents; Base Sequence; Carcinoma, Non-Small-Cell Lung; DNA Mutational Analysis; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Genes, erbB-1; Heterozygote; Humans; Lung Neoplasms; Male; Middle Aged; Molecular Sequence Data; Mutation; Protein-Tyrosine Kinases; Quinazolines; Sequence Deletion

2004
Insulin reduces the requirement for EGFR transactivation in bombesin-induced DNA synthesis.
    Biochemical and biophysical research communications, 2004, Jun-11, Volume: 318, Issue:4

    Topics: Animals; Bombesin; DNA; Drug Synergism; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Insulin; Mice; Protein Tyrosine Phosphatases; Quinazolines; Swiss 3T3 Cells; Thymidine; Transcriptional Activation; Tritium; Tyrphostins

2004
Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activity.
    British journal of pharmacology, 2004, Volume: 142, Issue:4

    Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gi-Go; Hong Kong; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-jun; Quinazolines; Receptors, G-Protein-Coupled; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; src-Family Kinases; Type C Phospholipases; Tyrphostins; Vascular Endothelial Growth Factor Receptor-2

2004
EGFR inhibitors square off at ASCO.
    Nature biotechnology, 2004, Volume: 22, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Drug Industry; Economic Competition; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Panitumumab; Quinazolines

2004
Cancer. A bull's eye for targeted lung cancer therapy.
    Science (New York, N.Y.), 2004, Jun-04, Volume: 304, Issue:5676

    Topics: Adenocarcinoma; Amino Acid Substitution; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Controlled Clinical Trials as Topic; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Genes, erbB-1; Humans; Japan; Ligands; Lung Neoplasms; Mutation; Phosphorylation; Protein Structure, Tertiary; Quinazolines; Sequence Deletion; Smoking; Treatment Outcome; United States

2004
Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer.
    British journal of cancer, 2004, Jul-19, Volume: 91, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Immunoenzyme Techniques; Lung Neoplasms; Male; Middle Aged; Predictive Value of Tests; Prognosis; Protein-Tyrosine Kinases; Quinazolines; Survival Rate

2004
Tamoxifen: Dr. Jekyll and Mr. Hyde?
    Journal of the National Cancer Institute, 2004, Jun-16, Volume: 96, Issue:12

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Clinical Trials as Topic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; Female; Gefitinib; Humans; Neoplasms, Hormone-Dependent; Phosphorylation; Quinazolines; Receptor Cross-Talk; Receptor, ErbB-2; Receptors, Estrogen; Retrospective Studies; Selective Estrogen Receptor Modulators; Tamoxifen; Trastuzumab

2004
Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer.
    Journal of the National Cancer Institute, 2004, Jun-16, Volume: 96, Issue:12

    Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; Estrogen Receptor Modulators; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor Cross-Talk; Receptor, ErbB-2; Receptors, Estrogen; Signal Transduction; Tamoxifen; Transplantation, Heterologous; Up-Regulation

2004
The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells.
    Thrombosis and haemostasis, 2004, Volume: 92, Issue:1

    Topics: Binding Sites; Cell Line; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; ErbB Receptors; Factor VIIa; Focal Adhesion Kinase 2; Heparin-binding EGF-like Growth Factor; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Interleukin-8; Keratinocytes; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Recombinant Proteins; RNA, Messenger; Signal Transduction; Thromboplastin; Transcription Factors; Tyrphostins

2004
[Effect of EGF on the intracellular distribution of heat-shock proteins in A431 cells].
    Tsitologiia, 2003, Volume: 45, Issue:8

    Topics: Antibodies, Monoclonal; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Estrenes; Fluorescent Antibody Technique; Heat-Shock Proteins; Hot Temperature; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Phosphorylation; Protein-Tyrosine Kinases; Pyrrolidinones; Quinazolines; Time Factors; Type C Phospholipases; Tyrphostins; Vanadates

2003
Gefitinib in recurrent glioblastoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jul-01, Volume: 22, Issue:13

    Topics: Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Disease-Free Survival; Endpoint Determination; Epidermal Growth Factor; Gefitinib; Glioblastoma; Humans; Neoplasm Recurrence, Local; Protein-Tyrosine Kinases; Quinazolines; Reproducibility of Results

2004
Cancer: understanding the target.
    Nature, 2004, Jul-01, Volume: 430, Issue:6995

    Topics: Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Lung Neoplasms; Mutation; Pharmacogenetics; Quinazolines; Randomized Controlled Trials as Topic

2004
Direct inhibition of EGF receptor activation in vascular endothelial cells by gefitinib ('Iressa', ZD1839).
    Cancer science, 2004, Volume: 95, Issue:7

    Topics: Antineoplastic Agents; Blotting, Western; Cell Culture Techniques; Endothelial Cells; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Immunohistochemistry; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Quinazolines

2004
Mechanisms of vascular angiotensin II surface receptor regulation by epidermal growth factor.
    Journal of cellular physiology, 2004, Volume: 200, Issue:3

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Cells, Cultured; Cytochalasin D; Dactinomycin; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Ligands; Muscle, Smooth, Vascular; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tyrphostins

2004
Gefitinib ('IRESSA', ZD1839) inhibits EGF-induced invasion in prostate cancer cells by suppressing PI3 K/AKT activation.
    Journal of cancer research and clinical oncology, 2004, Volume: 130, Issue:10

    Topics: Antineoplastic Agents; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Gefitinib; Humans; Immunoprecipitation; In Situ Nick-End Labeling; Male; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines

2004
Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells.
    Endocrinology, 2004, Volume: 145, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Heparin-binding EGF-like Growth Factor; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Mouth Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Receptor Cross-Talk; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrphostins

2004
Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xenograft
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:8

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Endothelium, Vascular; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Immunohistochemistry; Ki-67 Antigen; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Necrosis; Neoplasm Transplantation; Neovascularization, Pathologic; Organophosphorus Compounds; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Time Factors

2004
Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha.
    Molecular and cellular endocrinology, 2004, Sep-30, Volume: 224, Issue:1-2

    Topics: Androgens; Animals; Autocrine Communication; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gene Expression Regulation; Isoquinolines; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinases; Phosphoproteins; Quinazolines; Rats; RNA, Messenger; Steroids; Sulfonamides; Transforming Growth Factor alpha; Tyrphostins

2004
The combi-targeting concept: dissection of the binary mechanism of action of the combi-triazene SMA41 in vitro and antitumor activity in vivo.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:3

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Body Weight; Cell Cycle; Cell Line, Tumor; Chromatography, High Pressure Liquid; Comet Assay; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Delivery Systems; Epidermal Growth Factor; Flow Cytometry; Humans; Mice; Mice, SCID; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Neoplasms; Quinazolines; Signal Transduction

2004
Multiple mechanisms of action of ZR2002 in human breast cancer cells: a novel combi-molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA.
    International journal of cancer, 2004, Nov-10, Volume: 112, Issue:3

    Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Molecular Structure; Oncogene Proteins v-erbB; Phosphorylation; Platelet-Derived Growth Factor; Quinazolines; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured

2004
Angiotensin II regulation of TGF-beta in murine mesangial cells involves both PI3 kinase and MAP kinase.
    Annals of clinical and laboratory science, 2004,Summer, Volume: 34, Issue:3

    Topics: Angiotensin II; Animals; Butadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Mesangium; Immunoblotting; Losartan; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tyrphostins

2004
ERBB2 kinase mutations in lung-cancer tumours.
    The Lancet. Oncology, 2004, Volume: 5, Issue:11

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; DNA Mutational Analysis; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2

2004
Complications of therapy in cancer patients: Case 1. Paronychia and skin hyperpigmentation induced by gefitinib in advanced non-small-cell lung cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Nov-15, Volume: 22, Issue:22

    Topics: Adult; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Epidermal Growth Factor; Female; Gefitinib; Humans; Hyperpigmentation; Lung Neoplasms; Middle Aged; Paronychia; Protein-Tyrosine Kinases; Quinazolines

2004
Epidermal growth factor enhances TNF-alpha-induced priming of human neutrophils.
    Immunology letters, 2005, Jan-31, Volume: 96, Issue:2

    Topics: CD11b Antigen; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Humans; Inflammation; Interleukin-8; Neutrophils; Phagocytosis; Protein Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Respiratory Burst; Tumor Necrosis Factor-alpha; Tyrphostins

2005
PLC and PI3K pathways are important in the inhibition of EGF-induced cell migration by gefitinib ('Iressa', ZD1839).
    Breast cancer (Tokyo, Japan), 2004, Volume: 11, Issue:4

    Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Neoplasm Invasiveness; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; Type C Phospholipases

2004
EGF activates intracellular and intercellular calcium signaling by distinct pathways in tumor cells.
    Cancer biology & therapy, 2004, Volume: 3, Issue:12

    Topics: Adenosine Triphosphate; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Calcium; Calcium Signaling; Carcinoma, Squamous Cell; Cetuximab; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Glioma; Humans; Protein Kinase Inhibitors; Quinazolines; Receptors, Purinergic; Tumor Cells, Cultured

2004
Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis.
    The Journal of biological chemistry, 2005, Mar-04, Volume: 280, Issue:9

    Topics: Arachidonate 15-Lipoxygenase; Blotting, Western; Cell Membrane; Cell Proliferation; Cells, Cultured; Chromatography, High Pressure Liquid; Cornea; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Green Fluorescent Proteins; Hepatocyte Growth Factor; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Lipoxygenase; MAP Kinase Kinase Kinases; Microscopy, Fluorescence; Models, Biological; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Transport; Quinazolines; Signal Transduction; Time Factors; Transfection; Wound Healing

2005
[French experience of gefitinib in non-small cell bronchial carcinoma].
    Revue des maladies respiratoires, 2004, Volume: 21, Issue:5 Pt 1

    Topics: Adult; Aged; Antineoplastic Agents; Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Epidermal Growth Factor; Female; Gefitinib; Humans; Male; Middle Aged; Palliative Care; Protein-Tyrosine Kinases; Quinazolines; Retrospective Studies; Sex Factors; Smoking

2004
Coexpression of matrix metalloproteinase-7 (MMP-7) and epidermal growth factor (EGF) receptor in colorectal cancer: an EGF receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-15, Volume: 10, Issue:24

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Cell Nucleus; Colorectal Neoplasms; Cytoplasm; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Immunoenzyme Techniques; Male; Matrix Metalloproteinase 7; Middle Aged; Phosphorylation; Protein Transport; Quinazolines; Smad4 Protein; Trans-Activators; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured

2004
Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-15, Volume: 10, Issue:24

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Carcinoma, Papillary; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Mice; Mice, Nude; Paclitaxel; Phosphorylation; Quinazolines; Thyroid Neoplasms; Transforming Growth Factor alpha; Tumor Cells, Cultured

2004
Somatic mutations of EGFR in colorectal cancers and glioblastomas.
    The New England journal of medicine, 2004, Dec-30, Volume: 351, Issue:27

    Topics: Brain Neoplasms; Colorectal Neoplasms; DNA, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Genes, erbB-1; Glioblastoma; Point Mutation; Quinazolines

2004
Increase in amphiregulin and epiregulin in prostate cancer xenograft after androgen deprivation-impact of specific HER1 inhibition.
    The Prostate, 2005, Jun-15, Volume: 64, Issue:1

    Topics: Amphiregulin; Androgens; Animals; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Gefitinib; Gene Expression; Glycoproteins; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Orchiectomy; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; RNA, Messenger; Xenograft Model Antitumor Assays

2005
Growth of intestinal epithelium in organ culture is dependent on EGF signalling.
    Experimental cell research, 2005, Feb-15, Volume: 303, Issue:2

    Topics: Animals; Apoptosis; Body Patterning; Cell Proliferation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Female; Intestines; Mice; Mice, Inbred ICR; Organ Culture Techniques; Pregnancy; Quinazolines; Signal Transduction; Tyrphostins

2005
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.
    The Journal of cell biology, 2005, Jan-31, Volume: 168, Issue:3

    Topics: Actin Depolymerizing Factors; Actin-Related Protein 2; Actin-Related Protein 3; Actins; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Cytoskeletal Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Fibronectins; GRB2 Adaptor Protein; Microfilament Proteins; Microscopy, Fluorescence; Models, Biological; Neoplasm Invasiveness; Nerve Tissue Proteins; Oncogene Proteins; Quinazolines; Rats; RNA, Small Interfering; Transfection; Tyrphostins; Wiskott-Aldrich Syndrome Protein Family; Wiskott-Aldrich Syndrome Protein, Neuronal

2005
Additive antitumor effects of the epidermal growth factor receptor tyrosine kinase inhibitor, gefitinib (Iressa), and the nonsteroidal antiandrogen, bicalutamide (Casodex), in prostate cancer cells in vitro.
    International journal of cancer, 2005, Jul-01, Volume: 115, Issue:4

    Topics: Androgen Antagonists; Anilides; Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Dihydrotestosterone; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Male; Nitriles; Prostatic Neoplasms; Quinazolines; Tosyl Compounds; Transplantation, Heterologous

2005
Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner.
    American journal of respiratory cell and molecular biology, 2005, Volume: 32, Issue:5

    Topics: Amphiregulin; Autocrine Communication; Bronchi; Cells, Cultured; Compressive Strength; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Gene Expression Regulation; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Quinazolines; Respiratory Mucosa; Signal Transduction; Stress, Mechanical; Time Factors; Tyrphostins

2005
Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.
    Cancer chemotherapy and pharmacology, 2005, Volume: 55, Issue:6

    Topics: Amphiregulin; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Drug Screening Assays, Antitumor; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-8; Irinotecan; Phosphorylation; Quinazolines; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms; Transforming Growth Factor alpha; Tyrosine

2005
Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.
    Cancer research, 2005, Feb-15, Volume: 65, Issue:4

    Topics: Alkaloids; Benzophenanthridines; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Morpholines; Phenanthridines; Protein Kinase C; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2005
Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects.
    Cancer research, 2005, Feb-15, Volume: 65, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Growth Processes; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Estradiol; Female; Fulvestrant; Gefitinib; Humans; Lung Neoplasms; Male; Mice; Mice, SCID; Mitogen-Activated Protein Kinase 3; Quinazolines; Receptors, Estrogen; Xenograft Model Antitumor Assays

2005
Gefitinib ("Iressa", ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance.
    Cancer research, 2005, Feb-15, Volume: 65, Issue:4

    Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport, Active; Breast Neoplasms; Camptothecin; Carcinoma, Small Cell; Cell Line, Tumor; Cell Membrane; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Inhibitory Concentration 50; Irinotecan; Lung Neoplasms; Mitoxantrone; Neoplasm Proteins; Protein Kinase Inhibitors; Quinazolines; Topotecan

2005
Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Mar-15, Volume: 11, Issue:6

    Topics: Adenosine Triphosphate; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Binding Sites; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colonic Neoplasms; Drug Synergism; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lovastatin; Lung Neoplasms; Mevalonic Acid; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Quinazolines; Signal Transduction; Tumor Cells, Cultured

2005
Association of skin rash and tumor response to HER1/EGFR inhibition: does HER1 stimulated tumor growth depend on circulatory instead of paracrine ligands?
    Medical hypotheses, 2005, Volume: 64, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Autocrine Communication; Cetuximab; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Exanthema; Humans; Ligands; Models, Biological; Neoplasm Proteins; Neoplasms; Paracrine Communication; Quinazolines; Skin; Transforming Growth Factor alpha; Treatment Outcome

2005
Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib.
    British journal of cancer, 2005, May-09, Volume: 92, Issue:9

    Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Epidermal Growth Factor; Female; Gefitinib; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; Protein Kinase Inhibitors; Quinazolines; Tumor Necrosis Factor-alpha

2005
Pulmonary adenocarcinomas with mutant epidermal growth factor receptors.
    The New England journal of medicine, 2005, Apr-21, Volume: 352, Issue:16

    Topics: Adenocarcinoma; Antineoplastic Agents; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Ligands; Lung Neoplasms; Mutation, Missense; Quinazolines; Sequence Deletion; Stromal Cells; Transforming Growth Factor alpha

2005
Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases.
    Journal of neurochemistry, 2005, Volume: 93, Issue:4

    Topics: Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Genetic Vectors; Humans; Indole Alkaloids; Microscopy, Confocal; Neuroblastoma; Piperazines; Platelet-Derived Growth Factor; Quinazolines; Quinpirole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Dopamine D2; Simplexvirus; Spiperone; Transcriptional Activation; Transfection; Tritium; Tyrphostins

2005
EGF-induced EGF-receptor and MAP kinase phosphorylation in goat cumulus cells during in vitro maturation.
    Molecular reproduction and development, 2005, Volume: 71, Issue:4

    Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Goats; Immunoassay; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Ovarian Follicle; Phosphorylation; Quinazolines; Time Factors; Tyrphostins

2005
Autocrine regulation of human urothelial cell proliferation and migration during regenerative responses in vitro.
    Experimental cell research, 2005, May-15, Volume: 306, Issue:1

    Topics: Amphiregulin; Antibodies; Autocrine Communication; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Gene Expression; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Quinazolines; Regeneration; Transforming Growth Factor alpha; Urothelium; Wound Healing

2005
Epidermal growth factor modulates prostate cancer cell invasiveness regulating urokinase-type plasminogen activator activity. EGF-receptor inhibition may prevent tumor cell dissemination.
    Thrombosis and haemostasis, 2005, Volume: 93, Issue:5

    Topics: Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Chemotaxis; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Inhibitory Concentration 50; Laminin; Male; MAP Kinase Signaling System; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Monoester Hydrolases; Phosphorylation; Prostatic Neoplasms; Proteoglycans; PTEN Phosphohydrolase; Quinazolines; Receptor, ErbB-2; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Proteins; Urokinase-Type Plasminogen Activator

2005
Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2.
    Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:6

    Topics: Animals; Astrocytes; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Nitrobenzenes; Optic Nerve; Optic Nerve Injuries; Prostaglandin-Endoperoxide Synthases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Wistar; Sulfonamides; Tyrphostins

2005
A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes.
    Experimental cell research, 2005, Jul-01, Volume: 307, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Chlorocebus aethiops; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescence Recovery After Photobleaching; Fluorescence Resonance Energy Transfer; HeLa Cells; Humans; Immunoblotting; Kinetics; Microscopy, Video; Molecular Probes; Phosphorylation; Precipitin Tests; Protein Binding; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Quinazolines; Tyrosine; Tyrphostins

2005
The antitumor and antiangiogenic activity of vascular endothelial growth factor receptor inhibition is potentiated by ErbB1 blockade.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jun-15, Volume: 11, Issue:12

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Coculture Techniques; Drug Synergism; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Gefitinib; Humans; Immunoblotting; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Phthalazines; Platelet Endothelial Cell Adhesion Molecule-1; Protein Kinase Inhibitors; Pyridines; Quinazolines; Transplantation, Heterologous; Vascular Endothelial Growth Factor A

2005
beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
    The Journal of biological chemistry, 2005, Sep-16, Volume: 280, Issue:37

    Topics: Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epitopes; ErbB Receptors; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Lysophospholipids; Mice; Mice, Knockout; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Phosphorylation; Quinazolines; ras Proteins; RNA; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrphostins

2005
Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.
    International journal of oncology, 2005, Volume: 27, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Resistance, Neoplasm; Drug Synergism; Embryo, Mammalian; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Inhibitor of Apoptosis Proteins; Keratinocytes; Melanoma; Mice; Mice, Knockout; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Proteins; Pentacyclic Triterpenes; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Survivin; Time Factors; Triterpenes

2005
Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells.
    International journal of cancer, 2006, Feb-15, Volume: 118, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Proliferation; DNA Damage; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Hedgehog Proteins; Humans; Male; Prostatic Neoplasms; Quinazolines; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Veratrum Alkaloids

2006
Analogs of GnRH-I and GnRH-II inhibit epidermal growth factor-induced signal transduction and resensitize resistant human breast cancer cells to 4OH-tamoxifen.
    European journal of endocrinology, 2005, Volume: 153, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Estrogen Antagonists; Extracellular Signal-Regulated MAP Kinases; Female; Gefitinib; Gonadotropin-Releasing Hormone; Humans; Phosphorylation; Quinazolines; Signal Transduction; Tamoxifen; Triptorelin Pamoate

2005
Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer.
    BMC cancer, 2005, Oct-03, Volume: 5

    Topics: Antibodies, Monoclonal; beta-Lactamases; Butadienes; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Immunohistochemistry; Inhibitory Concentration 50; MAP Kinase Kinase 1; Neoplasms; Nitriles; Oligonucleotides, Antisense; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transfection; Tyrphostins

2005
Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression.
    Cancer research, 2005, Oct-01, Volume: 65, Issue:19

    Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Growth Processes; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Interleukin-3; Mice; Mutagenesis, Site-Directed; Mutation, Missense; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Transfection

2005
Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants.
    Oncogene, 2006, Feb-23, Volume: 25, Issue:8

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Immunoprecipitation; Lung Neoplasms; Mutation; Phosphorylation; Quinazolines; Tumor Cells, Cultured; Tyrosine; Ubiquitin

2006
Single-dose clinical pharmacokinetic studies of gefitinib.
    Clinical pharmacokinetics, 2005, Volume: 44, Issue:11

    Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fasting; Female; Gefitinib; Humans; Injections, Intravenous; Linear Models; Male; Middle Aged; Quinazolines; Suspensions; Tablets

2005
Direct involvement of G protein alpha(q/11) subunit in regulation of muscarinic receptor-mediated sAPPalpha release.
    Archives of pharmacal research, 2005, Volume: 28, Issue:11

    Topics: Amino Acid Sequence; Cell Line, Tumor; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Molecular Sequence Data; Muscarinic Agonists; Quinazolines; Receptor Cross-Talk; Receptor, Muscarinic M3; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Serum Amyloid A Protein; Transfection; Tyrphostins

2005
Regulation of signaling phosphoproteins by epidermal growth factor and Iressa (ZD1839) in human endometrial cancer cells that model type I and II tumors.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:12

    Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Endometrial Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Flow Cytometry; Gefitinib; Humans; Phosphoproteins; Quinazolines; Signal Transduction

2005
Response of endothelial cells to a dual tyrosine kinase receptor inhibition combined with irradiation.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:12

    Topics: Blotting, Western; Cell Division; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Epidermal Growth Factor; Gefitinib; Humans; Quinazolines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Vascular Endothelial Growth Factor A

2005
[Enhanced expression of EGFR, TGF-alpha, EGF in hyperplastic parathyroid glands in established stage of renal failure in rats].
    Clinical calcium, 2005, Volume: 15 Suppl 1

    Topics: Animals; Cell Proliferation; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Hyperplasia; Intracellular Signaling Peptides and Proteins; Male; Parathyroid Glands; Parathyroid Hormone; Phosphorus, Dietary; Quinazolines; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Time Factors; Transforming Growth Factor alpha

2005
Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.
    Biochemical and biophysical research communications, 2006, Mar-10, Volume: 341, Issue:2

    Topics: Androstadienes; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Infrared Rays; Intracellular Signaling Peptides and Proteins; Kinetics; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; Radiation, Ionizing; Signal Transduction; src-Family Kinases; Temperature; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Wortmannin; X-Rays

2006
Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons.
    Molecular and cellular neurosciences, 2006, Volume: 31, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Electrophysiology; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; gamma-Aminobutyric Acid; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ligands; Neurons; Protein Subunits; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Transforming Growth Factor alpha

2006
The epidermal growth factor receptor (EGFR)-S442F mutant displays increased affinity for neuregulin-2beta and agonist-independent coupling with downstream signalling events.
    The Biochemical journal, 2006, May-15, Volume: 396, Issue:1

    Topics: Amino Acid Substitution; Animals; Apoptosis; Binding Sites; Cell Line; Chromones; Epidermal Growth Factor; ErbB Receptors; Genes, erbB-1; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Mice; Morpholines; Mutation, Missense; Myeloid Cells; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphorylation; Point Mutation; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quinazolines; Recombinant Fusion Proteins; Signal Transduction; Transfection

2006
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.
    The Journal of cell biology, 2006, Jan-30, Volume: 172, Issue:3

    Topics: Animals; Animals, Newborn; Calcium; Caspase 3; Caspases; Cell Proliferation; Chromatin Immunoprecipitation; Chromones; Dermis; DNA; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression; Gene Expression Regulation; Hair Diseases; Integrases; Keratinocytes; Keratins; Ki-67 Antigen; MAP Kinase Signaling System; Mice; Mice, Transgenic; Morpholines; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Skin; Skin Abnormalities; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transforming Growth Factor alpha; Tyrphostins

2006
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.
    Cancer research, 2006, Feb-15, Volume: 66, Issue:4

    Topics: Aged; Bronchi; Cell Adhesion; Cell Growth Processes; Cell Transformation, Neoplastic; Dual Specificity Phosphatase 6; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Genes, erbB-1; Genes, p16; Genes, p53; Genes, ras; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase Kinases; Oncogenes; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-akt; Quinazolines; RNA Interference; STAT3 Transcription Factor; Telomerase; Transfection; Up-Regulation

2006
C-fos assessment as a marker of anti-epidermal growth factor receptor effect.
    Cancer research, 2006, Feb-15, Volume: 66, Issue:4

    Topics: Animals; Biomarkers, Tumor; Cell Growth Processes; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Genes, fos; Humans; Mice; Mice, Nude; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; Xenograft Model Antitumor Assays

2006
PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.
    Oncology reports, 2006, Volume: 15, Issue:4

    Topics: Cell Line, Tumor; Cell Movement; Dipeptides; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Kidney Neoplasms; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Oligopeptides; Phosphorylation; Pyrroles; Quinazolines; Receptor, PAR-1; Thrombin; Tyrosine; Tyrphostins

2006
EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms.
    Cancer research, 2006, Mar-15, Volume: 66, Issue:6

    Topics: Binding Sites; Carcinoma, Squamous Cell; Cell Line, Tumor; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Promoter Regions, Genetic; Protein Kinase Inhibitors; Quinazolines; Sp1 Transcription Factor; Vascular Endothelial Growth Factor A

2006
Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.
    Toxicology letters, 2006, Aug-20, Volume: 165, Issue:2

    Topics: Adult; Benzo(a)pyrene; Calcium; Calcium Signaling; Carcinogens, Environmental; Cells, Cultured; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Female; Genistein; Humans; Myometrium; Oxytocin; Pregnancy; Protein-Tyrosine Kinases; Quinazolines; Tetraethylammonium; Tyrphostins

2006
Leuprorelin acetate affects ERK1/2 activity in prostate cancer cells.
    International journal of oncology, 2006, Volume: 29, Issue:1

    Topics: Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Leuprolide; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Time Factors; Tyrphostins

2006
Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.
    European journal of pharmacology, 2006, Aug-07, Volume: 542, Issue:1-3

    Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Antibodies; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Endothelin-1; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Norepinephrine; Phenylalanine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Thiophenes; Tyrphostins; Wortmannin

2006
Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma.
    Cancer letters, 2007, Apr-08, Volume: 248, Issue:1

    Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines

2007
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.
    Cancer cell, 2006, Volume: 10, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Mice; Mice, Nude; Models, Biological; Morpholines; Mutation; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; RNA, Small Interfering; Transforming Growth Factor alpha; Trastuzumab; Xenograft Model Antitumor Assays

2006
GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.
    Molecular reproduction and development, 2006, Volume: 73, Issue:10

    Topics: Animals; Cell Adhesion Molecules; Cyclooxygenase 2; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Female; Glucuronosyltransferase; Gonadotropin-Releasing Hormone; Hyaluronan Synthases; Meiosis; Ovarian Follicle; Ovulation; Phosphorylation; Progesterone; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Tyrphostins

2006
Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux) results in paradox phosphorylation of tyrosine 1173 in the receptor.
    FEBS letters, 2006, Sep-04, Volume: 580, Issue:20

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Survival; Cetuximab; Cisplatin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Head and Neck Neoplasms; Humans; Phosphorylation; Quinazolines; Tyrosine; Tyrphostins

2006
EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer.
    Oncogene, 2007, Mar-08, Volume: 26, Issue:11

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Interleukin-3; Lung Neoplasms; Models, Molecular; Mutation; Phosphorylation; Protein Binding; Quinazolines

2007
AZD3409 inhibits the growth of breast cancer cells with intrinsic resistance to the EGFR tyrosine kinase inhibitor gefitinib.
    Breast cancer research and treatment, 2007, Volume: 102, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; Female; Flow Cytometry; Gefitinib; Humans; Protein-Tyrosine Kinases; Quinazolines

2007
Novel combination therapy against metastatic and androgen-independent prostate cancer by using gefitinib, tamoxifen and etoposide.
    International journal of cancer, 2007, Jan-01, Volume: 120, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Caspases; Cell Proliferation; Cells, Cultured; Ceramides; Cytochromes c; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Etoposide; Flow Cytometry; Gefitinib; Humans; Immunoenzyme Techniques; Male; Membrane Potential, Mitochondrial; Neoplasms, Hormone-Dependent; Prostate; Prostatic Neoplasms; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tamoxifen

2007
Signaling interactions of rapamycin combined with erlotinib in cervical carcinoma xenografts.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:10

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Interactions; Epidermal Growth Factor; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms, Experimental; Phosphorylation; Quinazolines; Ribosomal Protein S6; Signal Transduction; Sirolimus; Transplantation, Heterologous; Uterine Cervical Neoplasms

2006
Control of tight junctional sealing: role of epidermal growth factor.
    American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:2

    Topics: Adolescent; Adult; Animals; Cell Membrane Permeability; Cells, Cultured; Claudin-1; Claudin-4; Dogs; Electric Impedance; Epidermal Growth Factor; ErbB Receptors; Humans; Male; Membrane Proteins; Quinazolines; Tight Junctions

2007
The epidermal growth factor family has a dual role in deciding the fate of cancer cells.
    Scandinavian journal of clinical and laboratory investigation, 2006, Volume: 66, Issue:7

    Topics: Biomarkers; Cell Differentiation; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Ligands; Multigene Family; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; RNA, Messenger; Urinary Bladder Neoplasms

2006
Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy.
    Journal of cellular physiology, 2007, Volume: 210, Issue:2

    Topics: Adenoviridae; Adenoviridae Infections; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; eIF-2 Kinase; Enzyme Inhibitors; Epidermal Growth Factor; Gefitinib; Gene Expression Regulation, Neoplastic; Genetic Therapy; Genetic Vectors; Humans; Interleukins; Lung Neoplasms; Mutation; Quinazolines

2007
Insulin-induced proliferation of bladder cancer cells is mediated through activation of the epidermal growth factor system.
    The FEBS journal, 2006, Volume: 273, Issue:23

    Topics: Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Heparin-binding EGF-like Growth Factor; Humans; Insulin; Intercellular Signaling Peptides and Proteins; Ligands; Quinazolines; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrphostins; Up-Regulation; Urinary Bladder Neoplasms

2006
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.
    Endocrine-related cancer, 2006, Volume: 13, Issue:4

    Topics: Adenocarcinoma, Follicular; Aprotinin; Blotting, Western; Carcinoma, Papillary; Cell Differentiation; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Protease Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Serine Proteinase Inhibitors; Tetracyclines; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrphostins

2006
[EGFR pathway and mechanism of action of tyrosine kinase inhibitors].
    Revue de pneumologie clinique, 2007, Volume: 63, Issue:1 Pt 2

    Topics: Bronchial Neoplasms; Carcinoma, Non-Small-Cell Lung; Chromosomes, Human, Pair 7; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Genes, erbB-2; Genes, ras; Humans; Mutation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Respiratory Mucosa

2007
Identification of endosomal epidermal growth factor receptor signaling targets by functional organelle proteomics.
    Molecular & cellular proteomics : MCP, 2007, Volume: 6, Issue:5

    Topics: Cell Culture Techniques; Electrophoresis, Gel, Two-Dimensional; Endosomes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Proteins; Proteomics; Quinazolines; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2007
hEGR1 is induced by EGF, inhibited by gefitinib in bladder cell lines and related to EGF receptor levels in bladder tumours.
    British journal of cancer, 2007, Mar-12, Volume: 96, Issue:5

    Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Early Growth Response Protein 1; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Expression; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urinary Bladder Neoplasms

2007
Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6

    Topics: Animals; Bacterial Proteins; Cell Proliferation; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Pulmonary Veins; Quinazolines; Sheep; Signal Transduction; Time Factors; Transfection; Tyrphostins

2007
Epidermal growth factor-, transforming growth factor-beta-, retinoic acid- and 1,25-dihydroxyvitamin D3-regulated expression of the novel protein PTPIP51 in keratinocytes.
    Cells, tissues, organs, 2006, Volume: 184, Issue:2

    Topics: Calcitriol; Cell Line; Cell Nucleus; Cytoplasm; Epidermal Growth Factor; Gene Expression Regulation; Humans; Keratinocytes; Mitochondrial Proteins; Protein Tyrosine Phosphatases; Quinazolines; RNA, Messenger; Transforming Growth Factor beta; Tretinoin

2006
The EGFR inhibitor gefitinib suppresses ligand-stimulated endocytosis of EGFR via the early/late endocytic pathway in non-small cell lung cancer cell lines.
    Histochemistry and cell biology, 2007, Volume: 127, Issue:5

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cathepsin D; Cell Line, Tumor; Cell Membrane; Drug Resistance, Neoplasm; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lysosomal Membrane Proteins; Lysosomes; Microscopy, Fluorescence; Protein Transport; Qa-SNARE Proteins; Quinazolines; Receptors, Scavenger; Signal Transduction; Transferrin

2007
Epiregulin promotes proliferation and migration of renal proximal tubular cells.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:1

    Topics: Animals; Blotting, Western; Butadienes; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Rabbits; Tyrphostins; Wound Healing

2007
Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential.
    Toxicology and applied pharmacology, 2007, May-15, Volume: 221, Issue:1

    Topics: Antimony; Arsenites; beta Catenin; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Line, Transformed; Cell Proliferation; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Humans; Insulin; Keratinocytes; Male; Matrix Metalloproteinase 7; PPAR delta; Pyrimidines; Quinazolines; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tyrphostins

2007
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.
    The Biochemical journal, 2007, Jul-15, Volume: 405, Issue:2

    Topics: Acetophenones; Animals; Anthracenes; Benzamides; Chromones; Dioxoles; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heparin-binding EGF-like Growth Factor; Hepatocytes; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Morpholines; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Onium Compounds; Peptides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Transforming Growth Factor beta; Tyrphostins; Up-Regulation

2007
Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.
    Endocrinology, 2007, Volume: 148, Issue:7

    Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Dipeptides; Epidermal Growth Factor; Flavonoids; Immunohistochemistry; Inositol Phosphates; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyrazoles; Pyrimidines; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Steroids; Tyrphostins

2007
Gefitinib-sensitive EGFR lacking residues 746-750 exhibits hypophosphorylation at tyrosine residue 1045, hypoubiquitination, and impaired endocytosis.
    DNA and cell biology, 2007, Volume: 26, Issue:3

    Topics: Animals; Binding Sites; Chlorocebus aethiops; COS Cells; Drug Resistance, Neoplasm; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Ligands; Mice; Mutation; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Quinazolines; Sequence Deletion; Tyrosine; Ubiquitin

2007
Treatment of human epidermal growth factor receptor 2-overexpressing breast cancer xenografts with multiagent HER-targeted therapy.
    Journal of the National Cancer Institute, 2007, May-02, Volume: 99, Issue:9

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Estrogens; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; Mice; Mice, Nude; Quinazolines; Receptor, ErbB-2; Signal Transduction; Transplantation, Heterologous; Trastuzumab

2007
Immortalization of human urothelial cells by human papillomavirus type 16 E6 and E7 genes in a defined serum-free system.
    Cell proliferation, 2007, Volume: 40, Issue:2

    Topics: Animals; Cell Cycle; Cell Growth Processes; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Clone Cells; Culture Media, Serum-Free; Epidermal Growth Factor; ErbB Receptors; Genes, Viral; Human papillomavirus 16; Humans; Karyotyping; Keratins; Mice; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Papillomavirus Infections; Phenotype; Quinazolines; Repressor Proteins; Telomerase; Urothelium

2007
EGF-like peptides mediate FSH-induced maturation of cumulus cell-enclosed mouse oocytes.
    Molecular reproduction and development, 2008, Volume: 75, Issue:1

    Topics: Adenosine Monophosphate; Amphiregulin; Animals; Cells, Cultured; Cumulus Cells; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Glycoproteins; Intercellular Signaling Peptides and Proteins; Meiosis; Mice; Oocytes; Peptides; Protein Kinase C; Quinazolines; Tyrphostins

2008
Heparin-binding EGF-like growth factor mediates oxyhemoglobin-induced suppression of voltage-dependent potassium channels in rabbit cerebral artery myocytes.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:3

    Topics: Animals; Cerebral Arteries; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Metalloproteases; Myocytes, Smooth Muscle; Oxyhemoglobins; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Protein Kinase C; Quinazolines; Rabbits; Tyrphostins

2007
Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.
    Proteomics, 2007, Volume: 7, Issue:14

    Topics: Amino Acid Sequence; Cell Line, Tumor; Epidermal Growth Factor; Gefitinib; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microtubule-Associated Proteins; Molecular Sequence Data; Neoplasms; Phosphoproteins; Phosphotyrosine; Proteomics; Quinazolines; Serine Endopeptidases; Signal Transduction; Tandem Mass Spectrometry

2007
Uncoupling of the epidermal growth factor receptor from downstream signal transduction molecules guides the acquired resistance to gefitinib in prostate cancer cells.
    Oncology reports, 2007, Volume: 18, Issue:2

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Gefitinib; Humans; Male; Nerve Growth Factor; Phosphorylation; Prostatic Neoplasms; Quinazolines; Receptor, ErbB-2; Receptor, Nerve Growth Factor; Receptor, trkA; Receptor, trkB; Signal Transduction; Time Factors

2007
Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:3

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Dose-Response Relationship, Drug; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Ileum; Imidazoles; Mitochondria; Mitogen-Activated Protein Kinase 14; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinazolines; Rats; RNA Interference; RNA, Small Interfering; Signal Transduction; Time Factors; Tyrphostins

2007
Involvement of KATP and KvLQT1 K+ channels in EGF-stimulated alveolar epithelial cell repair processes.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 293, Issue:4

    Topics: Adenosine Triphosphate; Animals; Antibodies; Autocrine Communication; Benzothiazoles; Biological Transport; Cell Movement; Cell Proliferation; Cells, Cultured; Drug Synergism; Electric Conductivity; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; KCNQ1 Potassium Channel; Male; Pinacidil; Potassium; Potassium Channels; Protein Kinase Inhibitors; Pulmonary Alveoli; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Tyrphostins; Wound Healing

2007
Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes.
    Journal of cellular physiology, 2008, Volume: 214, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Cells, Cultured; Culture Media, Serum-Free; Cyclin D; Cyclins; Dinoprostone; DNA; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Gene Expression Regulation; Hepatocytes; Liver Neoplasms; Male; Pertussis Toxin; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tyrphostins

2008
Effects of a novel tyrosine kinase inhibitor in rheumatoid arthritis synovial fibroblasts.
    Annals of the rheumatic diseases, 2008, Volume: 67, Issue:3

    Topics: Apoptosis; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Humans; Inflammation Mediators; Lapatinib; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Protein Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Synovial Membrane

2008
Epidermal growth factor receptor inhibition modulates the nuclear localization and cytotoxicity of the Auger electron emitting radiopharmaceutical 111In-DTPA human epidermal growth factor.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007, Volume: 48, Issue:9

    Topics: Antineoplastic Agents; Cell Compartmentation; Cell Line, Tumor; Cell Nucleus; Electrons; Epidermal Growth Factor; ErbB Receptors; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Gefitinib; Humans; Indium Radioisotopes; Pentetic Acid; Phosphorylation; Protein Transport; Quinazolines; Radiopharmaceuticals; Signal Transduction

2007
EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.
    Cellular signalling, 2007, Volume: 19, Issue:12

    Topics: Animals; Apoptosis; Cell Survival; Cycloheximide; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibronectins; Integrin beta3; Intestinal Mucosa; MAP Kinase Kinase Kinases; Mice; Mutation; Oligopeptides; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphorylation; Polyamines; Protein Kinase Inhibitors; Putrescine; Pyrimidines; Quinazolines; Rats; Signal Transduction; src-Family Kinases; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins

2007
Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer.
    International journal of radiation oncology, biology, physics, 2007, Dec-01, Volume: 69, Issue:5

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; DNA Repair; Epidermal Growth Factor; ErbB Receptors; Feasibility Studies; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Piperidines; Pleural Effusion; Quinazolines; Radiation Tolerance; Radiation-Sensitizing Agents; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2007
EGF prevents the neuroendocrine differentiation of LNCaP cells induced by serum deprivation: the modulator role of PI3K/Akt.
    Neoplasia (New York, N.Y.), 2007, Volume: 9, Issue:8

    Topics: Adenocarcinoma; Androgens; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cell Differentiation; Cell Line, Tumor; Culture Media, Serum-Free; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Trastuzumab

2007
Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor.
    Endocrinology, 2007, Volume: 148, Issue:12

    Topics: ADAM Proteins; ADAM17 Protein; Amphiregulin; Animals; Blotting, Western; Cells, Cultured; Cumulus Cells; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Flavonoids; Follicle Stimulating Hormone; Gene Expression; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oocytes; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Swine; Transfection; Tyrphostins

2007
Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Kidney; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Inbred WKY; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Tyrphostins; Vasoconstrictor Agents

2008
Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:10

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Blotting, Western; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Dosage; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Phosphorylation; Purines; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor alpha; Xenograft Model Antitumor Assays

2007
Radiation-induced prevention of erlotinib-induced skin rash is transient: a new aspect toward the understanding of epidermal growth factor receptor inhibitor associated cutaneous adverse effects.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Oct-10, Volume: 25, Issue:29

    Topics: Adenocarcinoma; Back; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Drug Eruptions; Epidermal Growth Factor; Female; Humans; Lung Neoplasms; Lymphatic Metastasis; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Radiotherapy, Adjuvant; Skin

2007
EGFR genomic gain and aberrant pathway signaling in pancreatic cancer patients.
    The Journal of surgical research, 2007, Volume: 143, Issue:1

    Topics: Aged; Aged, 80 and over; Cell Line, Tumor; Cell Proliferation; Child, Preschool; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Female; Gene Dosage; Gene Expression Regulation, Neoplastic; Humans; Infant; Kaplan-Meier Estimate; Male; Middle Aged; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction

2007
Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity.
    Journal of cellular physiology, 2008, Volume: 215, Issue:1

    Topics: Animals; Cell Movement; Epidermal Growth Factor; Ion Channel Gating; Male; Prostatic Neoplasms; Quinazolines; Rats; Sodium Channels; Tetrodotoxin; Tyrphostins; Up-Regulation

2008
PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte.
    Domestic animal endocrinology, 2008, Volume: 34, Issue:4

    Topics: Animals; Butadienes; Cells, Cultured; Chromones; Cumulus Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Meiosis; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Swine; Tyrphostins

2008
In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:8

    Topics: Amino Acid Transport System ASC; Androstadienes; Blotting, Western; Caco-2 Cells; Cell Membrane; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamine; Humans; Minor Histocompatibility Antigens; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; rho GTP-Binding Proteins; RNA Interference; Signal Transduction; Sodium; Time Factors; Tyrphostins; Up-Regulation; Wortmannin

2008
Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway.
    Molecular endocrinology (Baltimore, Md.), 2008, Volume: 22, Issue:4

    Topics: Amphiregulin; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipeptides; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Glycoproteins; Hydroxamic Acids; Immunohistochemistry; Immunoprecipitation; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Mice; Mitogen-Activated Protein Kinases; Oocytes; Ovarian Follicle; Phosphorylation; Protein Biosynthesis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrphostins

2008
Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells.
    The Journal of biological chemistry, 2008, Apr-18, Volume: 283, Issue:16

    Topics: AC133 Antigen; Antigens, CD; Brain Neoplasms; Enzyme Inhibitors; Epidermal Growth Factor; Gefitinib; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Models, Biological; Peptides; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Stem Cells; Tumor Cells, Cultured; Tyrphostins

2008
Neutral 5-substituted 4-indazolylaminoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.
    Bioorganic & medicinal chemistry letters, 2008, Mar-15, Volume: 18, Issue:6

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dogs; Epidermal Growth Factor; ErbB Receptors; Ether-A-Go-Go Potassium Channels; Female; Hepatocytes; Humans; Indazoles; Keratinocytes; Lapatinib; Male; Metabolic Clearance Rate; Mice; Mice, Nude; Mice, SCID; Microsomes; Molecular Structure; Neoplasms, Experimental; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; Receptor, ErbB-2; Survival Rate; Xenograft Model Antitumor Assays

2008
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab.
    Cancer research, 2008, Mar-15, Volume: 68, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Line, Tumor; Cetuximab; Class I Phosphatidylinositol 3-Kinases; Colonic Neoplasms; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; G1 Phase; Gene Dosage; Genes, ras; HCT116 Cells; Humans; MAP Kinase Signaling System; Mutation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins B-raf; PTEN Phosphohydrolase; Quinazolines; ras Proteins; Resting Phase, Cell Cycle; RNA, Messenger

2008
Contact spotting of protein microarrays coupled with spike-in of normalizer protein permits time-resolved analysis of ERBB receptor signaling.
    Proteomics, 2008, Volume: 8, Issue:8

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Glutathione Transferase; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Array Analysis; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Recombinant Fusion Proteins; Reference Standards; Signal Transduction; Trastuzumab; Tumor Cells, Cultured

2008
Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors.
    The Prostate, 2008, Jun-15, Volume: 68, Issue:9

    Topics: Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Erlotinib Hydrochloride; Flow Cytometry; Humans; Male; Morpholines; Neoplasms, Hormone-Dependent; Phosphorylcholine; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines

2008
Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs.
    Cancer letters, 2008, Aug-08, Volume: 266, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; Mice; Ovarian Neoplasms; Paclitaxel; Protein Kinase Inhibitors; Quinazolines; Signal Transduction

2008
Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes.
    The Journal of endocrinology, 2008, Volume: 197, Issue:2

    Topics: Animals; Cells, Cultured; Cumulus Cells; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Meiosis; Oocytes; Phosphorylation; Protein Kinase C; Quinazolines; Receptors, Androgen; Swine; Tetradecanoylphorbol Acetate; Tyrphostins

2008
Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.
    Microvascular research, 2008, Volume: 76, Issue:1

    Topics: Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Cinnamates; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Humans; Male; Mice; Mice, Nude; Neoplasms, Experimental; Neuropilin-1; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Transplantation, Heterologous; Tyrphostins; Vascular Endothelial Growth Factor Receptor-2

2008
Effects of gangliosides on the differentiation of human mesenchymal stem cells into osteoblasts by modulating epidermal growth factor receptors.
    Biochemical and biophysical research communications, 2008, Jul-11, Volume: 371, Issue:4

    Topics: Alkaline Phosphatase; Cell Differentiation; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Gangliosides; Humans; Mesenchymal Stem Cells; Osteoblasts; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2008
Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line.
    Molecular cancer, 2008, May-21, Volume: 7

    Topics: Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Lysosomes; Microscopy, Fluorescence; Phosphorylation; Quinazolines; Signal Transduction; Sorting Nexins; Vesicular Transport Proteins

2008
Response of malignant thymoma to erlotinib.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:7

    Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Epidermal Growth Factor; Erlotinib Hydrochloride; Fatal Outcome; Gefitinib; Humans; Immunohistochemistry; Protein Kinase Inhibitors; Quinazolines; Thymoma

2008
Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.
    American journal of physiology. Cell physiology, 2008, Volume: 295, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Cell Line; Down-Regulation; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Ligands; Lysosomes; Macrolides; Phosphoproteins; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Quinazolines; Recombinant Fusion Proteins; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transfection; Tyrphostins

2008
EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src.
    American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 295, Issue:3

    Topics: Adenosine Triphosphate; Bronchi; Cell Line; Chloride Channels; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Patch-Clamp Techniques; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Recombinant Proteins; Signal Transduction; Tyrphostins

2008
HTS assays using a disease-relevant cell model for interrogating the MAP kinase pathway initiated by multiple receptors.
    Assay and drug development technologies, 2008, Volume: 6, Issue:3

    Topics: Cell Line, Tumor; Epidermal Growth Factor; Female; Hepatocyte Growth Factor; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Proto-Oncogene Proteins; Quinazolines; Receptors, Cell Surface

2008
EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy.
    Neuro-oncology, 2008, Volume: 10, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Drug Delivery Systems; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gene Dosage; Genes, p16; Genes, p53; Humans; Immunohistochemistry; Nerve Sheath Neoplasms; Polymorphism, Single-Stranded Conformational; PTEN Phosphohydrolase; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor alpha; Trastuzumab

2008
Rhenium and technetium complexes bearing quinazoline derivatives: progress towards a 99mTc biomarker for EGFR-TK imaging.
    Dalton transactions (Cambridge, England : 2003), 2008, Jun-28, Issue:24

    Topics: Biomarkers; Carcinoma, Squamous Cell; Cell Proliferation; Chelating Agents; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Epidermal Growth Factor; ErbB Receptors; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Organotechnetium Compounds; Phosphorylation; Quinazolines; Rhenium; Tumor Cells, Cultured

2008
Displayed correlation between gene expression profiles and submicroscopic alterations in response to cetuximab, gefitinib and EGF in human colon cancer cell lines.
    BMC cancer, 2008, Aug-08, Volume: 8

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Cell Survival; Cetuximab; Cluster Analysis; Colonic Neoplasms; Epidermal Growth Factor; Gefitinib; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Microscopy, Electron, Scanning; Microvilli; Oligonucleotide Array Sequence Analysis; Quinazolines

2008
Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2008, Volume: 7, Issue:9

    Topics: Cell Line, Tumor; Cell Membrane; Cell Survival; Epidermal Growth Factor; ErbB Receptors; Humans; Lysosomes; Phosphorylation; Photosensitizing Agents; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2008
Proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations: identification of new signaling elements.
    Molecular carcinogenesis, 2009, Volume: 48, Issue:3

    Topics: Animals; Antineoplastic Agents; Carcinoma, Medullary; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Germ-Line Mutation; Humans; Mice; Mice, Nude; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Oncogene Proteins; Phosphorylation; Proteomics; Proto-Oncogene Proteins c-ret; Quinazolines; Signal Transduction; Thyroid Neoplasms; Tyrosine

2009
Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors.
    Journal of controlled release : official journal of the Controlled Release Society, 2008, Dec-18, Volume: 132, Issue:3

    Topics: Cells, Cultured; Chemistry, Pharmaceutical; Drug Carriers; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Fibrosis; Gene Expression Regulation; Humans; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Kinetics; Muramidase; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Quinazolines; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

2008
The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.
    Biochimica et biophysica acta, 2009, Volume: 1793, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Isoenzymes; Liver Neoplasms; Mitochondria; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Protein Kinase Inhibitors; Quinazolines; Rats; Reactive Oxygen Species; RNA, Small Interfering; Transforming Growth Factor beta; Tyrphostins

2009
A role for SNX5 in the regulation of macropinocytosis.
    BMC cell biology, 2008, Oct-14, Volume: 9

    Topics: Animals; Carrier Proteins; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophage Activation; Macrophages; Membrane Lipids; Membrane Proteins; Mice; Phosphatidylinositol Phosphates; Pinocytosis; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; Sorting Nexins; Transgenes; Tyrphostins; Vesicular Transport Proteins

2008
The role of targeted agents in the treatment of elderly patients with non-small cell lung cancer (NSCLC).
    Current treatment options in oncology, 2008, Volume: 9, Issue:4-6

    Topics: Age Factors; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Vascular Endothelial Growth Factor A

2008
Receptor overexpression or inhibition alters cell surface dynamics of EGF-EGFR interaction: new insights from real-time single molecule analysis.
    Biochemical and biophysical research communications, 2009, Jan-16, Volume: 378, Issue:3

    Topics: Cell Membrane; Dimerization; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Microscopy, Fluorescence; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2009
Antitumor effect in medulloblastoma cells by gefitinib: Ectopic HER2 overexpression enhances gefitinib effects in vivo.
    Neuro-oncology, 2009, Volume: 11, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Gefitinib; Gene Expression; Humans; Male; Medulloblastoma; Mice; Mice, Nude; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Xenograft Model Antitumor Assays

2009
Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice.
    Translational research : the journal of laboratory and clinical medicine, 2008, Volume: 152, Issue:6

    Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Intubation, Intratracheal; Mice; Mice, Inbred Strains; Neutrophils; Permeability; Protein Tyrosine Phosphatases; Pulmonary Alveoli; Quinazolines; Signal Transduction; Tyrphostins; Ventilator-Induced Lung Injury; Ventilators, Mechanical

2008
Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling.
    Toxicology letters, 2009, Feb-10, Volume: 184, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic CMP; Dose-Response Relationship, Drug; Down-Regulation; Endocrine Disruptors; Enzyme Activators; Epidermal Growth Factor; ErbB Receptors; Genistein; Leydig Cells; Luteinizing Hormone; Male; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Long-Evans; Receptors, LH; Signal Transduction; Testosterone; Tyrphostins

2009
Growth factors involved in aqueous humour-induced lens cell proliferation.
    Growth factors (Chur, Switzerland), 2009, Volume: 27, Issue:1

    Topics: Animals; Aqueous Humor; Cell Proliferation; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; Fibroblast Growth Factors; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Lens, Crystalline; Platelet-Derived Growth Factor; Pyrroles; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tyrphostins

2009
Role of epidermal growth factor gene in the development of pancreatic cancer and efficiency of inhibitors of this gene in the treatment of pancreatic carcinoma.
    Bulletin of experimental biology and medicine, 2008, Volume: 145, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Proliferation; Drug Evaluation, Preclinical; Epidermal Growth Factor; ErbB Receptors; Fluorouracil; Gene Frequency; Genetic Predisposition to Disease; Humans; Pancreatic Neoplasms; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Quinazolines; Time Factors; Tumor Cells, Cultured; Tyrphostins

2008
Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice.
    Journal of the National Cancer Institute, 2009, Jan-21, Volume: 101, Issue:2

    Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cyclin D1; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Precancerous Conditions; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; RNA, Messenger; Signal Transduction

2009
Arsenic activates EGFR pathway signaling in the lung.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 109, Issue:2

    Topics: Adult; Aged; Amphiregulin; Analysis of Variance; Arsenic; Arsenites; Biomarkers; Bronchi; Cells, Cultured; Cyclin D1; Cycloheximide; EGF Family of Proteins; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Lung; Lung Neoplasms; Middle Aged; Nails; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sodium Compounds

2009
Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma.
    The Journal of biological chemistry, 2009, Apr-10, Volume: 284, Issue:15

    Topics: Active Transport, Cell Nucleus; Aryl Hydrocarbon Receptor Nuclear Translocator; Carcinoma, Squamous Cell; Cell Line, Tumor; Cobalt; Cyclooxygenase 2; Epidermal Growth Factor; Female; Humans; Microscopy, Fluorescence; Models, Biological; Promoter Regions, Genetic; Quinazolines; RNA, Messenger; Tyrphostins; Uterine Cervical Neoplasms

2009
Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling.
    American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:4

    Topics: Animals; Animals, Newborn; Anthracenes; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Epidermal Growth Factor; ErbB Receptors; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Recombinant Proteins; Signal Transduction; Sp1 Transcription Factor; Tissue Inhibitor of Metalloproteinase-3

2009
Desmoid cell motility is induced in vitro by rhEGF.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2009, Volume: 27, Issue:9

    Topics: Benzamides; Cell Division; Cell Line, Tumor; Cell Movement; Culture Media, Serum-Free; Dioxoles; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibromatosis, Aggressive; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Integrin beta1; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Quinazolines; Receptors, Transforming Growth Factor beta; Recombinant Proteins; RNA, Messenger; RNA, Small Interfering; Soft Tissue Neoplasms; STAT3 Transcription Factor; Transforming Growth Factor alpha; Tyrphostins

2009
Erlotinib-induced dermatologic side-effects.
    International journal of dermatology, 2009, Volume: 48, Issue:3

    Topics: Acneiform Eruptions; Aged; Antineoplastic Agents; Chickenpox; Drug Eruptions; Epidermal Growth Factor; Erlotinib Hydrochloride; Female; Herpesvirus 3, Human; Humans; Protein Kinase Inhibitors; Quinazolines; Virus Activation

2009
Role for cumulus cell-produced EGF-like ligands during primate oocyte maturation in vitro.
    American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:5

    Topics: Amphiregulin; Animals; Betacellulin; Cumulus Cells; EGF Family of Proteins; Embryonic Development; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Fertilization in Vitro; Glycoproteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Macaca mulatta; Oocytes; Phosphorylation; Pregnancy; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrphostins

2009
Lapatinib, a dual inhibitor of ErbB-1/-2 receptors, enhances effects of combination chemotherapy in bladder cancer cells.
    International journal of oncology, 2009, Volume: 34, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Separation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Inhibitory Concentration 50; Lapatinib; Phosphorylation; Quinazolines; Receptor, ErbB-2; Signal Transduction; Treatment Outcome; Urinary Bladder Neoplasms

2009
Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.
    Journal of vascular surgery, 2009, Volume: 49, Issue:5

    Topics: Aged; Ankle; Becaplermin; Blood Pressure; Cell Proliferation; Cells, Cultured; Constriction, Pathologic; DNA Replication; Epidermal Growth Factor; Female; Fibroblasts; Graft Occlusion, Vascular; Heparin; Humans; Hyperplasia; Lower Extremity; Lysophospholipids; Male; Middle Aged; Myocytes, Smooth Muscle; Peripheral Vascular Diseases; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Saphenous Vein; Sphingosine; Thrombin; Time Factors; Tyrphostins; Ultrasonography, Doppler, Duplex; Vascular Patency

2009
Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Apr-01, Volume: 15, Issue:7

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Clinical Trials, Phase I as Topic; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Head and Neck Neoplasms; Humans; Inhibitory Concentration 50; NF-kappa B; Phosphorylation; Protein Array Analysis; Protein Kinase Inhibitors; Proteomics; Quinazolines; Signal Transduction

2009
Activation of the calcium-sensing receptor by high calcium induced breast cancer cell proliferation and TRPC1 cation channel over-expression potentially through EGFR pathways.
    Archives of biochemistry and biophysics, 2009, Jun-01, Volume: 486, Issue:1

    Topics: Base Sequence; Breast Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Dipeptides; DNA Primers; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Receptors, Calcium-Sensing; Transcriptional Activation; TRPC Cation Channels; Tyrphostins

2009
Antitumor activity of the HER2 dimerization inhibitor pertuzumab on human colon cancer cells in vitro and in vivo.
    Journal of cancer research and clinical oncology, 2009, Volume: 135, Issue:10

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Camptothecin; Cell Cycle; Cell Line, Tumor; Colorectal Neoplasms; Dimerization; Drug Therapy, Combination; Epidermal Growth Factor; Erlotinib Hydrochloride; Female; Humans; In Vitro Techniques; Irinotecan; Mice; Mice, Nude; Protein Multimerization; Quinazolines; Receptor, ErbB-2; Xenograft Model Antitumor Assays

2009
Receptor tyrosine kinases as mediators of injury-induced bradykinin B1 receptor expression in rabbit aortic smooth muscle.
    European journal of pharmacology, 2009, Mar-15, Volume: 606, Issue:1-3

    Topics: Animals; Aorta; Bradykinin; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Interleukin-1; Muscle Contraction; Myocytes, Smooth Muscle; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rabbits; Receptor Protein-Tyrosine Kinases; Receptor, Bradykinin B1; Tyrphostins; Up-Regulation

2009
Epidermal growth factor competes with EGF receptor inhibitors to induce cell death in EGFR-overexpressing tumor cells.
    Cancer letters, 2009, Oct-08, Volume: 283, Issue:2

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cetuximab; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Gefitinib; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Quinazolines; Signal Transduction

2009
EGF-induced MMP-9 expression is mediated by the JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line.
    Cellular signalling, 2009, Volume: 21, Issue:6

    Topics: Breast Neoplasms; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Matrix Metalloproteinase 9; Phosphorylation; Quinazolines; RNA, Messenger; RNA, Small Interfering; STAT3 Transcription Factor; Tyrphostins

2009
Pharmacological interplay between breast cancer resistance protein and gefitinib in epidermal growth factor receptor signaling.
    Anticancer research, 2009, Volume: 29, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Chromatography, High Pressure Liquid; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Neoplasm Proteins; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tumor Cells, Cultured

2009
KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin.
    Development (Cambridge, England), 2009, Volume: 136, Issue:13

    Topics: Amphiregulin; Animals; beta Catenin; Cadherins; Cell Differentiation; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Glycoproteins; Hair Follicle; Hedgehog Proteins; Heparin-binding EGF-like Growth Factor; Hyaluronan Receptors; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Morphogenesis; Oncogene Proteins; Quinazolines; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Skin; Syndecan-1; Tissue Culture Techniques; Trans-Activators; Tyrphostins; Vibrissae; Wnt Proteins; Zinc Finger Protein GLI1

2009
Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.
    Journal of periodontal research, 2009, Volume: 44, Issue:1

    Topics: Cells, Cultured; Collagen Type I; Culture Media; Enzyme Inhibitors; Enzyme Precursors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gelatinases; Gingiva; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Matrix Metalloproteinase 14; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptors, Cell Surface; Signal Transduction; Transcriptional Activation; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Tyrphostins

2009
An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris.
    Experimental dermatology, 2009, Volume: 18, Issue:9

    Topics: Acantholysis; Animals; Apoptosis; Betacellulin; Carrier Proteins; Disease Models, Animal; Enzyme Activation; Epidermal Growth Factor; Epidermis; ErbB Receptors; Erlotinib Hydrochloride; Humans; Immunoglobulin G; Intercellular Signaling Peptides and Proteins; Intradermal Tests; Isoenzymes; Mice; Mice, Inbred C57BL; Pemphigus; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Quinazolines; Sirolimus; src-Family Kinases; TOR Serine-Threonine Kinases; Transforming Growth Factor alpha

2009
Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells.
    Journal of receptor and signal transduction research, 2009, Volume: 29, Issue:3-4

    Topics: Antineoplastic Agents; Biosensing Techniques; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Neoplasms; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Quinazolines; Signal Transduction

2009
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.
    Genes & development, 2009, Aug-15, Volume: 23, Issue:16

    Topics: ADAM Proteins; ADAMTS1 Protein; Animals; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Cell Differentiation; Cell Line; Cell Proliferation; Epidermal Growth Factor; Female; Gefitinib; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Silencing; Matrix Metalloproteinase 1; Mice; Mice, Nude; Osteoblasts; Osteoprotegerin; Protein Kinase Inhibitors; Quinazolines; RANK Ligand; Signal Transduction

2009
Cyclooxygenase-2 (COX-2) negatively regulates expression of epidermal growth factor receptor and causes resistance to gefitinib in COX-2-overexpressing cancer cells.
    Molecular cancer research : MCR, 2009, Volume: 7, Issue:8

    Topics: Cyclooxygenase 2; Dinoprostone; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HCT116 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Messenger; Transcription, Genetic

2009
Restoration of BRAK / CXCL14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head and neck squamous cell carcinoma.
    Cancer science, 2009, Volume: 100, Issue:11

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Chemokines, CXC; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Head and Neck Neoplasms; Humans; Mutation; Quinazolines; RNA, Messenger

2009
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
    Molecular and cellular biology, 2009, Volume: 29, Issue:20

    Topics: Anthracenes; Butadienes; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Imidazoles; Lactones; MAP Kinase Kinase Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Resorcinols; RNA, Small Interfering; Serine; Signal Transduction; Threonine; Tumor Necrosis Factor-alpha

2009
Simultaneous detection of ERK-, p38-, and JNK-MAPK phosphorylation in human adipose-derived stem cells using the Cytometric Bead Array technology.
    Journal of immunological methods, 2009, Oct-31, Volume: 350, Issue:1-2

    Topics: Adipose Tissue; Adult; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Flow Cytometry; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mesenchymal Stem Cells; Microspheres; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Tyrphostins

2009
Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.
    Stem cells (Dayton, Ohio), 2009, Volume: 27, Issue:11

    Topics: Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Computational Biology; Epidermal Growth Factor; Humans; Immunoassay; Least-Squares Analysis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multivariate Analysis; Osteogenesis; Phosphoproteins; Phosphotransferases; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Stem Cells; Stromal Cells; Tyrphostins

2009
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.
    The Journal of clinical investigation, 2009, Volume: 119, Issue:10

    Topics: Afatinib; Amphiregulin; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Disease Models, Animal; Drug Resistance, Neoplasm; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Profiling; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Male; Mice; Mice, Nude; Mice, Transgenic; Mutation; Neoplasm Transplantation; Paclitaxel; Protein Kinase Inhibitors; Quinazolines; Transplantation, Heterologous; Tumor Cells, Cultured

2009
Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:1

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Butadienes; Cell Culture Techniques; Cell Migration Assays; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; src-Family Kinases; Syk Kinase; Transcriptional Activation; Tyrphostins

2010
Role of epidermal growth factor inhibition in experimental pulmonary hypertension.
    American journal of respiratory and critical care medicine, 2010, Jan-15, Volume: 181, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Epidermal Growth Factor; Erlotinib Hydrochloride; Gefitinib; Gene Expression; Humans; Hypertension, Pulmonary; Lapatinib; Male; Mice; Muscle, Smooth, Vascular; Polymerase Chain Reaction; Protein Kinase Inhibitors; Pulmonary Wedge Pressure; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vascular Resistance

2010
Androgen-responsive and -unresponsive prostate cancer cell lines respond differently to stimuli inducing neuroendocrine differentiation.
    International journal of andrology, 2010, Volume: 33, Issue:6

    Topics: Androgens; Cell Differentiation; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Male; Neuroendocrine Cells; Phosphopyruvate Hydratase; Prostatic Neoplasms; Quinazolines; Receptors, Androgen

2010
Epidermal growth factor can be used in lieu of follicle-stimulating hormone for nuclear maturation of porcine oocytes in vitro.
    Theriogenology, 2010, Volume: 73, Issue:8

    Topics: Animals; Cell Nucleus; Cells, Cultured; Drug Interactions; Embryo Culture Techniques; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Growth Factor; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Oocytes; Oogenesis; Protein Biosynthesis; Quinazolines; Swine; Therapeutic Equivalency; Tyrphostins

2010
Bioactivity and molecular targets of novel substituted quinolines in murine and human tumor cell lines in vitro.
    International journal of oncology, 2010, Volume: 36, Issue:3

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA; Epidermal Growth Factor; Ethidium; Gap Junctions; HSP90 Heat-Shock Proteins; Humans; Mice; Nucleosides; Pyrroles; Quinazolines; Quinolines; Signal Transduction

2010
Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.
    American journal of physiology. Lung cellular and molecular physiology, 2010, Volume: 298, Issue:4

    Topics: Arginase; Cell Hypoxia; Cell Proliferation; Endothelial Cells; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Lung; Microvessels; Models, Biological; Quinazolines; RNA, Messenger; RNA, Small Interfering; Time Factors; Tyrphostins; Urea

2010
Duplexed on-microbead binding assay for competitive inhibitor of epidermal growth factor receptor by quantitative flow cytometry.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Competitive Bidding; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Flow Cytometry; Humans; Microspheres; Protein Binding; Protein Kinase Inhibitors; Quinazolines

2010
Role of epidermal growth factor receptor degradation in cisplatin-induced cytotoxicity in head and neck cancer.
    Cancer research, 2010, Apr-01, Volume: 70, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Head and Neck Neoplasms; Humans; Phosphorylation; Proto-Oncogene Proteins c-cbl; Quinazolines; Ubiquitin

2010
Diagnosis of synchronous primary lung adenocarcinomas based on epidermal growth factor (EGFR) gene status: A case report.
    Lung cancer (Amsterdam, Netherlands), 2010, Volume: 68, Issue:3

    Topics: Adenocarcinoma; Aged; Diagnosis, Differential; DNA Mutational Analysis; Epidermal Growth Factor; Female; Gefitinib; Humans; Lung Neoplasms; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasms, Multiple Primary; Pneumonectomy; Quinazolines; Radiography, Thoracic

2010
Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo.
    Neurochemistry international, 2010, Volume: 57, Issue:4

    Topics: Ammonia; Animals; Astrocytes; Blotting, Western; Brain; Cell Membrane; Cells, Cultured; Dipeptides; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Genes, src; Hyperammonemia; Isoenzymes; Mice; Protease Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Tyrphostins; Urease

2010
Receptor activation and inhibition in cellular response to chemotherapeutic combinational mimicries: the concept of divergent targeting.
    Journal of neuro-oncology, 2010, Volume: 100, Issue:3

    Topics: Analysis of Variance; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Dacarbazine; DNA Damage; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Gefitinib; Gene Expression Regulation, Neoplastic; Glioma; Humans; Models, Biological; Mutation; Octreotide; Phosphorylation; Quinazolines; Signal Transduction; Temozolomide; Time Factors; Transfection

2010
Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling.
    Developmental biology, 2010, Aug-15, Volume: 344, Issue:2

    Topics: Animals; Epidermal Growth Factor; Epidermis; Epiregulin; ErbB Receptors; Fatty Acid Transport Proteins; Keratinocytes; Mice; Mice, Mutant Strains; Mice, Transgenic; Mutation; Phenotype; Quinazolines; Signal Transduction; Skin; Skin Diseases; STAT3 Transcription Factor; Tyrphostins

2010
Luteolin and gefitinib regulation of EGF signaling pathway and cell cycle pathway genes in PC-3 human prostate cancer cells.
    The Journal of steroid biochemistry and molecular biology, 2010, Volume: 122, Issue:4

    Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Luteolin; Male; Prostatic Neoplasms; Quinazolines; Signal Transduction

2010
Modulation of P-gp expression by lapatinib.
    Investigational new drugs, 2011, Volume: 29, Issue:6

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Lung Neoplasms; Male; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Time Factors

2011
The epidermal growth factor receptor modulates DNA double-strand break repair by regulating non-homologous end-joining.
    DNA repair, 2010, Aug-05, Volume: 9, Issue:8

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bronchi; Cell Line, Tumor; Cetuximab; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase Kinases; Quinazolines; RNA, Small Interfering; Signal Transduction

2010
Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics.
    Science signaling, 2010, Jul-27, Volume: 3, Issue:132

    Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Immunoblotting; Lapatinib; Models, Biological; PC12 Cells; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Ribosomal Protein S6; Signal Transduction

2010
Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH.
    Reproduction (Cambridge, England), 2010, Volume: 140, Issue:5

    Topics: Amphiregulin; Animals; Cyclic GMP; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Gap Junctions; Glycoproteins; Immunoblotting; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Meiosis; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Ovarian Follicle; Quinazolines; Tyrphostins

2010
IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin.
    The Journal of biological chemistry, 2010, Dec-10, Volume: 285, Issue:50

    Topics: Biotinylation; Breast; Breast Neoplasms; Cell Line, Tumor; Epidermal Growth Factor; Fibronectins; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor Binding Protein 3; Laminin; MAP Kinase Signaling System; Phosphorylation; Quinazolines; Radioimmunoassay; rho-Associated Kinases

2010
Mitochondrially localized EGFR is independent of its endocytosis and associates with cell viability.
    Acta biochimica et biophysica Sinica, 2010, Volume: 42, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Cell Survival; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Etoposide; Gefitinib; Green Fluorescent Proteins; Humans; Immunoblotting; Microscopy, Immunoelectron; Mitochondria; Mitochondrial Proteins; Mutation; Protein Transport; Quinazolines

2010
Mechanisms of myogenic tone of coronary arteriole: Role of down stream signaling of the EGFR tyrosine kinase.
    Microvascular research, 2011, Volume: 81, Issue:1

    Topics: Animals; Arterioles; Cells, Cultured; Coronary Vessels; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; Janus Kinases; Mice; Mice, Inbred C57BL; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; Nitroprusside; Phosphorylation; Potassium Chloride; Pressure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Son of Sevenless Proteins; STAT Transcription Factors; STAT3 Transcription Factor; Tyrphostins; Vasoconstriction; Vasodilation

2011
Epidermal growth factor treatment switches δ-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor-dependent mechanism.
    Molecular pharmacology, 2011, Volume: 79, Issue:2

    Topics: Blotting, Western; Cell Line; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Humans; Microfluidics; Microscopy, Confocal; Phosphorylation; Quinazolines; Receptor, IGF Type 1; Receptors, Opioid, delta; Transcriptional Activation; Tyrphostins

2011
EGF-dependent induction of BCL-xL and p21CIP1/WAF1 is highly variable in HNSCC cells--implications for EGFR-targeted therapies.
    Anticancer research, 2010, Volume: 30, Issue:11

    Topics: bcl-X Protein; Blotting, Western; Carcinoma, Squamous Cell; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Head and Neck Neoplasms; Humans; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tyrphostins

2010
Estrogen receptor β exerts tumor repressive functions in human malignant pleural mesothelioma via EGFR inactivation and affects response to gefitinib.
    PloS one, 2010, Nov-29, Volume: 5, Issue:11

    Topics: Blotting, Western; Caveolin 1; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Estrogen Receptor beta; Gefitinib; Humans; Immunoprecipitation; Mesothelioma; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pleural Neoplasms; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; RNA Interference

2010
Endosomal signalling of epidermal growth factor receptors contributes to EGF-stimulated cell cycle progression in primary hepatocytes.
    European journal of pharmacology, 2011, Mar-05, Volume: 654, Issue:2

    Topics: Animals; Cell Cycle; Cell Division; Endosomes; Epidermal Growth Factor; ErbB Receptors; Hepatocytes; Male; Microscopy, Confocal; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Thymidine; Tyrphostins

2011
Tumour response to gefitinib is associated with EGF- and gefitinib- but not radiation-modulated EGFR expression.
    Anticancer research, 2010, Volume: 30, Issue:12

    Topics: Antineoplastic Agents; Cell Growth Processes; Cell Line, Tumor; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Melanoma; Neoplasms; Protein Kinase Inhibitors; Quinazolines

2010
Targeted therapy of VEGFR2 and EGFR significantly inhibits growth of anaplastic thyroid cancer in an orthotopic murine model.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-15, Volume: 17, Issue:8

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Immunoblotting; In Situ Nick-End Labeling; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Phosphorylation; Piperidines; Platelet Endothelial Cell Adhesion Molecule-1; Quinazolines; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Tumor Burden; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2011
Comparing the epidermal growth factor interaction with four different cell lines: intriguing effects imply strong dependency of cellular context.
    PloS one, 2011, Jan-31, Volume: 6, Issue:1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Kinetics; Protein Binding; Quinazolines; Signal Transduction

2011
EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:7

    Topics: 3T3 Cells; Alkaline Phosphatase; Amphiregulin; Animals; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Genetic Markers; Glycoproteins; Heparin-binding EGF-like Growth Factor; Histone Deacetylase 6; Histone Deacetylases; Humans; Integrin-Binding Sialoprotein; Intercellular Signaling Peptides and Proteins; Mice; Neuregulin-1; Osteoblasts; Osteocalcin; Osteogenesis; Quinazolines; Signal Transduction; Sp7 Transcription Factor; Transcription Factors; Transcription, Genetic; Transforming Growth Factor alpha

2011
Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice.
    Breast cancer research : BCR, 2011, Mar-11, Volume: 13, Issue:2

    Topics: Aldehyde Dehydrogenase 1 Family; Animals; BRCA1 Protein; Breast; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Female; Genes, BRCA1; Genes, p53; Humans; Isoenzymes; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Kinase Inhibitors; Quinazolines; Receptors, Estrogen; Retinal Dehydrogenase; RNA Interference

2011
Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.
    Cancer letters, 2011, Jul-01, Volume: 306, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Gefitinib; Genes, ras; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; Phosphorylation; Quinazolines; ras Proteins; Vulvar Neoplasms

2011
Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling.
    Biochimica et biophysica acta, 2011, Volume: 1813, Issue:6

    Topics: Blotting, Western; Cyclin-Dependent Kinase Inhibitor p27; Epidermal Growth Factor; ErbB Receptors; HEK293 Cells; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Multimerization; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptors, Somatostatin; RNA Interference; Signal Transduction; Somatostatin; Tyrphostins

2011
Good clinical response to erlotinib in a patient with anaplastic thyroid carcinoma harboring an epidermal growth factor somatic mutation, L858R, in exon 21.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Jun-01, Volume: 29, Issue:16

    Topics: Adenocarcinoma, Papillary; Aged; Antineoplastic Agents; Carcinoma, Signet Ring Cell; DNA Mutational Analysis; Epidermal Growth Factor; Erlotinib Hydrochloride; Exons; Female; Humans; Immunohistochemistry; Mutation; Polymerase Chain Reaction; Quinazolines; Thyroid Neoplasms

2011
β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells.
    Oncogene, 2011, Sep-29, Volume: 30, Issue:39

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antibodies, Monoclonal; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cisplatin; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Integrin beta1; Lung Neoplasms; Membrane Proteins; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Transplantation; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Transplantation, Heterologous

2011
Quantitative assays for the measurement of HER1-HER2 heterodimerization and phosphorylation in cell lines and breast tumors: applications for diagnostics and targeted drug mechanism of action.
    Breast cancer research : BCR, 2011, Apr-15, Volume: 13, Issue:2

    Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Lapatinib; Phosphorylation; Protein Kinase Inhibitors; Protein Multimerization; Quinazolines; Receptor, ErbB-2; Signal Transduction; Staining and Labeling; Treatment Outcome

2011
Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis.
    Molecular reproduction and development, 2011, Volume: 78, Issue:6

    Topics: Animals; Benzamides; C-Reactive Protein; Cell Adhesion Molecules; Cumulus Cells; Dioxoles; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation, Developmental; Glucuronosyltransferase; Hyaluronic Acid; Isoquinolines; Meiosis; Mice; Oocytes; Progesterone; Pyridines; Pyrroles; Quinazolines; Serum Amyloid P-Component; Signal Transduction; Smad2 Protein; Smad3 Protein; Swine; Tyrphostins

2011
A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFβ in pancreatic cancer cells.
    Cancer biology & therapy, 2011, Aug-01, Volume: 12, Issue:3

    Topics: Animals; Benzamides; Carcinoma, Pancreatic Ductal; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Cisplatin; Culture Media; Deoxycytidine; Dioxoles; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Matrix; Gemcitabine; Humans; Mice; Mice, Transgenic; Pancreatic Neoplasms; Quinazolines; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Microenvironment

2011
Positive interaction between lapatinib and capecitabine in human breast cancer models: study of molecular determinants.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Capecitabine; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Female; Fluorouracil; Humans; Lapatinib; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Thymidine Phosphorylase; Thymidylate Synthase; Xenograft Model Antitumor Assays

2012
ErbB expression, activation, and inhibition with lapatinib and tyrphostin (AG825) in human vestibular schwannomas.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2011, Volume: 32, Issue:5

    Topics: Benzothiazoles; Cell Cycle; Cell Proliferation; Epidermal Growth Factor; Humans; Lapatinib; Neuroma, Acoustic; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2011
Clinical significance of serum hepatocyte growth factor and epidermal growth factor gene somatic mutations in patients with non-squamous non-small cell lung cancer receiving gefitinib or erlotinib.
    Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Erlotinib Hydrochloride; Female; Gefitinib; Hepatocyte Growth Factor; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Mutation; Prognosis; Proportional Hazards Models; Quinazolines

2012
Modular anti-EGFR and anti-Her2 targeting of SK-BR-3 and BT474 breast cancer cell lines in the presence of ErbB receptor-specific growth factors.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2011, Volume: 79, Issue:9

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; Female; Humans; Lapatinib; Neuregulin-1; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Trastuzumab

2011
Epidermal growth factor enhances the malignant phenotype in canine mammary carcinoma cell lines.
    Veterinary and comparative oncology, 2011, Volume: 9, Issue:3

    Topics: Animals; Apoptosis; Cell Line, Tumor; Dog Diseases; Dogs; Epidermal Growth Factor; ErbB Receptors; Female; Mammary Neoplasms, Animal; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; Quinazolines; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2011
Epigen is induced during the interleukin-13-stimulated cell proliferation in murine primary airway epithelial cells.
    Experimental lung research, 2011, Volume: 37, Issue:8

    Topics: Animals; Cell Culture Techniques; Cell Proliferation; Cell Separation; Cells, Cultured; Epidermal Growth Factor; Epigen; Epithelial Cells; ErbB Receptors; Interleukin-13; Ligands; Mice; Quinazolines; Trachea; Tyrphostins

2011
Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor.
    Journal of cell science, 2011, Sep-15, Volume: 124, Issue:Pt 18

    Topics: Amphiregulin; Animals; Breast Neoplasms; Cell Growth Processes; Cell Line; Cell Movement; Cell Transformation, Neoplastic; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Mammary Glands, Human; MAP Kinase Signaling System; Mice; Mice, Transgenic; Quinazolines; Receptor, Fibroblast Growth Factor, Type 1

2011
The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines.
    International journal of oncology, 2012, Volume: 40, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cetuximab; Colonic Neoplasms; Drug Delivery Systems; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; HCT116 Cells; HT29 Cells; Humans; Quinazolines; Radiation-Sensitizing Agents; Recombinant Fusion Proteins; Signal Transduction

2012
Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.
    BMC cancer, 2011, Sep-06, Volume: 11

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Head and Neck Neoplasms; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Quinazolines; Signal Transduction; Sirolimus; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Tyrphostins

2011
Gefitinib induces epidermal growth factor receptor dimers which alters the interaction characteristics with ¹²⁵I-EGF.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Antineoplastic Agents; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Iodine Radioisotopes; Protein Binding; Protein Multimerization; Quinazolines

2011
A systems biology approach to model neural stem cell regulation by notch, shh, wnt, and EGF signaling pathways.
    Omics : a journal of integrative biology, 2011, Volume: 15, Issue:10

    Topics: Basic Helix-Loop-Helix Transcription Factors; Computer Simulation; Epidermal Growth Factor; Erlotinib Hydrochloride; Gene Expression; Gene Expression Regulation; Hedgehog Proteins; Homeodomain Proteins; Humans; Models, Biological; Neural Stem Cells; Protein Interaction Mapping; Protein Kinase Inhibitors; Quinazolines; Receptors, Notch; Signal Transduction; Systems Biology; Transcription Factor HES-1; Wnt Proteins

2011
Mucin glycosylating enzyme GALNT2 regulates the malignant character of hepatocellular carcinoma by modifying the EGF receptor.
    Cancer research, 2011, Dec-01, Volume: 71, Issue:23

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Knockdown Techniques; Glycosylation; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mucins; N-Acetylgalactosaminyltransferases; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Polypeptide N-acetylgalactosaminyltransferase; Quinazolines; RNA, Messenger

2011
Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:6

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Transformed; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; MAP Kinase Signaling System; Morphine; Quinazolines; Receptors, Opioid, mu

2011
Effect of epidermal growth factor on follicle-stimulating hormone-induced proliferation of granulosa cells from chicken prehierarchical follicles.
    Journal of Zhejiang University. Science. B, 2011, Volume: 12, Issue:11

    Topics: Animals; Apoptosis; Cell Growth Processes; Chickens; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Granulosa Cells; In Situ Nick-End Labeling; Ovarian Follicle; Proliferating Cell Nuclear Antigen; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tyrphostins

2011
Anti-tumour activity of 4-(4-fluorophenyl)amino-5,6,7-trimethoxyquinazoline against tumour cells in vitro.
    Cell biology international, 2012, Apr-01, Volume: 36, Issue:4

    Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Prostatic Neoplasms; Quinazolines; Signal Transduction

2012
Mechanistic insights into the activation of oncogenic forms of EGF receptor.
    Nature structural & molecular biology, 2011, Nov-20, Volume: 18, Issue:12

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cetuximab; Epidermal Growth Factor; ErbB Receptors; HEK293 Cells; Humans; Kinetics; Lapatinib; Lung Neoplasms; Models, Molecular; Mutation; Quinazolines; Tumor Suppressor Proteins

2011
Ovarian expression and regulation of the stromelysins during the periovulatory period in the human and the rat.
    Biology of reproduction, 2012, Volume: 86, Issue:3

    Topics: Animals; Cells, Cultured; Epidermal Growth Factor; Female; Granulosa Cells; Hormone Antagonists; Humans; Matrix Metalloproteinase 10; Matrix Metalloproteinase 11; Matrix Metalloproteinase 3; Mifepristone; Ovary; Ovulation; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Species Specificity; Theca Cells; Tyrphostins

2012
Protein expression signatures for inhibition of epidermal growth factor receptor-mediated signaling.
    Molecular & cellular proteomics : MCP, 2012, Volume: 11, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cetuximab; Chromatography, Liquid; Colorectal Neoplasms; Epidermal Growth Factor; ErbB Receptors; Gastritis, Hypertrophic; Gefitinib; Humans; Mice; Neoplasms; Neoplasms, Glandular and Epithelial; Phosphorylation; Prospective Studies; Proteomics; Quinazolines; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transplantation, Heterologous

2012
Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression.
    Clinical & experimental metastasis, 2012, Volume: 29, Issue:3

    Topics: Animals; Bone Neoplasms; Carcinoma, Small Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Male; Mice; Neoplasm Metastasis; Neovascularization, Pathologic; Osteoblasts; Osteoclasts; Protein Kinase Inhibitors; Quinazolines; RANK Ligand

2012
A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors.
    Anticancer research, 2012, Volume: 32, Issue:1

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Gefitinib; High-Throughput Screening Assays; Humans; Lung Neoplasms; Mutation; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Signal Transduction

2012
Regulation of human thyroid follicular cell function by inhibition of vascular endothelial growth factor receptor signalling.
    Molecular and cellular endocrinology, 2012, Apr-04, Volume: 351, Issue:2

    Topics: Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organotechnetium Compounds; Phosphorylation; Plasminogen Activators; Protein Kinase C; Quinazolines; Rats; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Vascular Endothelial Growth Factor A

2012
Epidermal growth factor upregulates endometrial CYR61 expression via activation of the JAK2/STAT3 pathway.
    Reproduction, fertility, and development, 2012, Volume: 24, Issue:3

    Topics: Antineoplastic Agents; Cells, Cultured; Cysteine-Rich Protein 61; Drug Evaluation, Preclinical; Endometrium; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Humans; Janus Kinase 2; MAP Kinase Signaling System; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Tyrphostins; Up-Regulation

2012
Regulated intramembrane cleavage of the EGF receptor.
    Traffic (Copenhagen, Denmark), 2012, Volume: 13, Issue:8

    Topics: Amyloid Precursor Protein Secretases; Calpain; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Glycoproteins; HEK293 Cells; Humans; Ionomycin; Proteolysis; Quinazolines; Serine Endopeptidases; Serine Proteinase Inhibitors; Tyrphostins

2012
Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells.
    Biochimica et biophysica acta, 2012, Volume: 1823, Issue:6

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Binding Sites; Butadienes; Cell Line, Tumor; Claudins; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protease Inhibitors; Protein Binding; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transcription Factor AP-1; Tyrphostins

2012
Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis.
    Archives of biochemistry and biophysics, 2012, Sep-01, Volume: 525, Issue:1

    Topics: Animals; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mutation; Protein Kinase Inhibitors; Quinazolines; rab GTP-Binding Proteins; rab5 GTP-Binding Proteins; Tyrphostins

2012
Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway.
    Toxicon : official journal of the International Society on Toxinology, 2012, Volume: 60, Issue:5

    Topics: Analysis of Variance; Blotting, Western; Cell Line, Tumor; Cell Movement; Cobra Cardiotoxin Proteins; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Metastasis; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins

2012
Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands.
    International journal of oncology, 2012, Volume: 41, Issue:3

    Topics: Androgens; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Betacellulin; Cell Line, Tumor; Cell Proliferation; Cetuximab; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Intercellular Signaling Peptides and Proteins; Male; Neuregulin-1; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; RNA, Messenger

2012
EGFR S1166 phosphorylation induced by a combination of EGF and gefitinib has a potentially negative impact on lung cancer cell growth.
    Journal of proteome research, 2012, Aug-03, Volume: 11, Issue:8

    Topics: Amino Acid Motifs; Amino Acid Sequence; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Serine; Tandem Mass Spectrometry; Tyrosine

2012
Epidermal growth factor enhances MPC-83 pancreatic cancer cell migration through the upregulation of aquaporin 3.
    Molecular medicine reports, 2012, Volume: 6, Issue:3

    Topics: Antineoplastic Agents; Aquaporin 3; Butadienes; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Nitriles; Pancreatic Neoplasms; Phosphorylation; Quinazolines; Up-Regulation

2012
A novel epidermal growth factor-dependent extracellular signal-regulated MAP kinase cascade involved in sperm functionality in sheep.
    Biology of reproduction, 2012, Volume: 87, Issue:4

    Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Quinazolines; Sheep; Sperm Capacitation; Spermatozoa; Tissue Distribution; Tyrphostins

2012
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.
    American journal of respiratory and critical care medicine, 2012, Oct-01, Volume: 186, Issue:7

    Topics: Animals; Benzamides; Benzimidazoles; Case-Control Studies; Crk-Associated Substrate Protein; Disease Models, Animal; Endothelial Cells; Epidermal Growth Factor; Familial Primary Pulmonary Hypertension; Fibroblast Growth Factor 2; Gefitinib; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Mice; Monocrotaline; Myocytes, Smooth Muscle; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pulmonary Artery; Pyrimidines; Quinazolines; Quinolones; Rats; Signal Transduction

2012
Differential effect of growth factors on invasion and proliferation of endocrine resistant breast cancer cells.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Benzamides; Breast Neoplasms; Cell Movement; Cell Proliferation; Chemokine CCL5; Chromones; Collagenases; Diphenylamine; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Female; Gene Knockdown Techniques; Humans; Insulin-Like Growth Factor I; Lymphokines; MCF-7 Cells; Morpholines; Phosphorylation; Platelet-Derived Growth Factor; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Estrogen; RNA, Small Interfering; Transforming Growth Factor beta

2012
Role of GRB2-associated binder 1 in epidermal growth factor receptor-induced signaling in head and neck squamous cell carcinoma.
    International journal of cancer, 2013, Mar-01, Volume: 132, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; GRB2 Adaptor Protein; Head and Neck Neoplasms; Humans; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Squamous Cell Carcinoma of Head and Neck

2013
EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis.
    Cell proliferation, 2012, Volume: 45, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Colonic Neoplasms; Epidermal Growth Factor; Gefitinib; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplastic Stem Cells; Quinazolines; Signal Transduction

2012
Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis.
    Neoplasia (New York, N.Y.), 2012, Volume: 14, Issue:8

    Topics: Animals; Butadienes; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; Female; Focal Adhesion Kinase 1; Humans; Integrin alpha6beta4; Lapatinib; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Metastasis; Nitriles; Phosphorylation; Quinazolines; Receptor, ErbB-2; Tetraspanin 24; Transendothelial and Transepithelial Migration

2012
Mechanisms involved in PGE2-induced transactivation of the epidermal growth factor receptor in MH1C1 hepatocarcinoma cells.
    Journal of experimental & clinical cancer research : CR, 2012, Sep-11, Volume: 31

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Dinoprostone; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Signal Transduction

2012
Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.
    The Journal of biological chemistry, 2012, Nov-02, Volume: 287, Issue:45

    Topics: Animals; Binding Sites; Blotting, Western; Cell Line; Cross-Linking Reagents; Disulfides; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Microscopy, Electron; Mutation; Phosphotransferases; Protein Conformation; Protein Kinase Inhibitors; Protein Multimerization; Protein Structure, Tertiary; Quinazolines

2012
Treatment of epidermal growth factor receptor inhibitor-induced acneiform eruption with topical recombinant human epidermal growth factor.
    Dermatology (Basel, Switzerland), 2012, Volume: 225, Issue:2

    Topics: Acneiform Eruptions; Antineoplastic Agents; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Drug Eruptions; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Quinazolines; Treatment Outcome; Tumor Cells, Cultured

2012
Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Adenocarcinoma; Cell Line, Tumor; Computational Biology; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neoplasm Staging; Prognosis; Quinazolines; Reproducibility of Results

2012
Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Nov-15, Volume: 18, Issue:22

    Topics: Adaptor Proteins, Signal Transducing; Animals; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Crk-Associated Substrate Protein; Disease-Free Survival; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Gene Knockdown Techniques; Humans; Integrins; Kaplan-Meier Estimate; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Multivariate Analysis; Neoplasm Transplantation; Phosphoproteins; Phosphorylation; Proportional Hazards Models; Protein Processing, Post-Translational; Quinazolines; Receptor Cross-Talk; Retrospective Studies; RNA, Small Interfering; Signal Transduction

2012
Norcantharidin suppresses cell growth and migration with enhanced anticancer activity of gefitinib and cisplatin in human non-small cell lung cancer cells.
    Oncology reports, 2013, Volume: 29, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Cisplatin; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Fluorescent Antibody Technique; Gefitinib; Humans; Lung Neoplasms; Mutation; Phosphorylation; Quinazolines; Signal Transduction; Tumor Cells, Cultured

2013
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.
    Molecular cell, 2013, Jan-24, Volume: 49, Issue:2

    Topics: Benzamides; Cell Line; Cell Proliferation; Diphenylamine; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Humans; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Microscopy, Fluorescence; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; S Phase Cell Cycle Checkpoints; Time-Lapse Imaging

2013
Epidermal growth factor receptor inhibitors for treatment of orbital squamous cell carcinoma.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2012, Volume: 130, Issue:12

    Topics: Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cetuximab; Epidermal Growth Factor; Erlotinib Hydrochloride; Female; Humans; Male; Orbital Neoplasms; Protein Kinase Inhibitors; Quinazolines

2012
Migration of retinal pigment epithelial cells is EGFR/PI3K/AKT dependent.
    Frontiers in bioscience (Scholar edition), 2013, 01-01, Volume: 5, Issue:2

    Topics: Cell Growth Processes; Cell Line; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Retinal Pigment Epithelium; Retinaldehyde; Signal Transduction; Tyrphostins

2013
Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Feb-15, Volume: 19, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Death; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Forkhead Box Protein O3; Forkhead Transcription Factors; Gefitinib; Humans; Protein Kinase Inhibitors; Quinazolines; Signal Transduction

2013
Epidermal growth factor regulates hematopoietic regeneration after radiation injury.
    Nature medicine, 2013, Volume: 19, Issue:3

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Female; Hematopoiesis; Hematopoietic Stem Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Kinase Inhibitors; Quinazolines; Radiation Injuries, Experimental; Regeneration; Signal Transduction; Tumor Suppressor Proteins; Whole-Body Irradiation

2013
Cross-talk between EGFR and T-cadherin: EGFR activation promotes T-cadherin localization to intercellular contacts.
    Cellular signalling, 2013, Volume: 25, Issue:5

    Topics: Cadherins; Cell Communication; Cell Line, Tumor; Cytoskeleton; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lapatinib; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; rac1 GTP-Binding Protein; Signal Transduction

2013
Thyroid cancer cell resistance to gefitinib depends on the constitutive oncogenic activation of the ERK pathway.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Genes, ras; Humans; MAP Kinase Signaling System; Mutation; Neoplasm Invasiveness; Phosphorylation; Proto-Oncogene Proteins B-raf; Quinazolines; Thyroid Neoplasms

2013
ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions.
    Translational psychiatry, 2013, Apr-30, Volume: 3

    Topics: Animals; Antipsychotic Agents; Brain Chemistry; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Male; Motor Activity; Quinazolines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Schizophrenic Psychology

2013
Activated EGFR stimulates MUC1 expression in human uterine and pancreatic cancer cell lines.
    Journal of cellular biochemistry, 2013, Volume: 114, Issue:10

    Topics: Blotting, Western; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Humans; Mucin-1; Pancreatic Neoplasms; Quinazolines; Rosiglitazone; Thiazolidinediones; Tyrphostins; Uterine Neoplasms

2013
Significant increase in hEGF uptake is correlated with formation of EGFR dimers induced by the EGFR tyrosine kinase inhibitor gefitinib.
    Cancer chemotherapy and pharmacology, 2013, Volume: 72, Issue:2

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cross-Linking Reagents; Dimerization; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Iodine Radioisotopes; Isotope Labeling; Panitumumab; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines

2013
EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors.
    The Prostate, 2013, Volume: 73, Issue:13

    Topics: Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Male; Phosphorylation; Prostate; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purines; Quinazolines; Sodium-Glucose Transporter 1

2013
Synthesis and anticancer activities of 5,6,7-trimethoxy-N-phenyl(ethyl)-4-aminoquinazoline derivatives.
    European journal of medicinal chemistry, 2013, Volume: 66

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Epidermal Growth Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Prohibitins; Quinazolines

2013
Dynamic conformational transitions of the EGF receptor in living mammalian cells determined by FRET and fluorescence lifetime imaging microscopy.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2013, Volume: 83, Issue:9

    Topics: Animals; Cell Membrane; CHO Cells; Cricetulus; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Models, Molecular; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins

2013
[EGFR-ERK signaling pathway down-regulates miRNA-145 in lung cancer cells].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2013, Volume: 35, Issue:3

    Topics: Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Lung; Lung Neoplasms; MAP Kinase Signaling System; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Quinazolines; Tyrphostins

2013
Profibrotic TGFβ responses require the cooperative action of PDGF and ErbB receptor tyrosine kinases.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:11

    Topics: Animals; Benzamides; Bleomycin; Cell Line; Drug Interactions; Epidermal Growth Factor; ErbB Receptors; Feedback, Physiological; Imatinib Mesylate; Lapatinib; Lung; Mice; Myofibroblasts; Paracrine Communication; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pulmonary Fibrosis; Pulmonary Gas Exchange; Pyrimidines; Quinazolines; Receptor, ErbB-2; Receptors, Platelet-Derived Growth Factor; Transforming Growth Factor beta; Up-Regulation

2013
microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF-β actions.
    Oncogene, 2014, Sep-18, Volume: 33, Issue:38

    Topics: Acetyltransferases; Animals; Antineoplastic Agents; Base Sequence; Binding Sites; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Epidermal Growth Factor; Erlotinib Hydrochloride; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 4; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Neoplasm Transplantation; Pancreatic Neoplasms; Quinazolines; RNA Interference; Signal Transduction; Transcription Factors; Transforming Growth Factor beta

2014
Epidermal growth factor enhances androgen receptor‑mediated bladder cancer progression and invasion via potentiation of AR transactivation.
    Oncology reports, 2013, Volume: 30, Issue:6

    Topics: Androgens; Animals; Butylhydroxybutylnitrosamine; Carcinogenesis; Castration; Disease Models, Animal; Disease Progression; Epidermal Growth Factor; ErbB Receptors; Humans; Male; Mice; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Quinazolines; Receptors, Androgen; Signal Transduction; Transcriptional Activation; Urinary Bladder Neoplasms

2013
The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Dec-15, Volume: 191, Issue:12

    Topics: Androstadienes; Antigen Presentation; Antigens, Neoplasm; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, MHC Class I; HLA-A Antigens; Humans; Lapatinib; MAP Kinase Signaling System; Neoplasm Proteins; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; RNA, Small Interfering; Signal Transduction; Stomach Neoplasms; Wortmannin

2013
GnRH-(1-5) transactivates EGFR in Ishikawa human endometrial cells via an orphan G protein-coupled receptor.
    Molecular endocrinology (Baltimore, Md.), 2014, Volume: 28, Issue:1

    Topics: Calcium Signaling; Cell Line, Tumor; Cell Movement; Endometrial Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Gonadotropin-Releasing Hormone; Humans; Matrix Metalloproteinase Inhibitors; Oligopeptides; Oncogene Proteins; Peptide Fragments; Phenylalanine; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; Quinazolines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, LHRH; Thiophenes; Transcriptional Activation; Tyrphostins

2014
EpCAM expression in the prostate cancer makes the difference in the response to growth factors.
    Biochemical and biophysical research communications, 2014, Jan-03, Volume: 443, Issue:1

    Topics: AMP-Activated Protein Kinases; Antigens, Neoplasm; Biomarkers, Tumor; Cell Adhesion Molecules; Cell Line, Tumor; Epidermal Growth Factor; Epithelial Cell Adhesion Molecule; ErbB Receptors; Gefitinib; Humans; Large Neutral Amino Acid-Transporter 1; Male; Neoplastic Stem Cells; Prostatic Neoplasms; Quinazolines; Signal Transduction; Tumor Microenvironment

2014
EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Feb-01, Volume: 192, Issue:3

    Topics: Administration, Cutaneous; Allergens; Animals; Cells, Cultured; Chemokine CXCL1; Chemokine CXCL2; Dermatitis, Atopic; Disease Progression; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation; Humans; Interleukin-17; Interleukin-1beta; Interleukin-22; Interleukin-6; Interleukins; Keratinocytes; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Quinazolines; Recurrence; Signal Transduction; Skin; Specific Pathogen-Free Organisms; Th17 Cells

2014
Combined treatment with sodium butyrate and PD153035 enhances keratinocyte differentiation.
    Experimental dermatology, 2014, Volume: 23, Issue:3

    Topics: Antineoplastic Agents; Butyric Acid; Cell Differentiation; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Filaggrin Proteins; Histamine Antagonists; Humans; Intermediate Filament Proteins; Keratinocytes; Quinazolines; RNA, Messenger; Transglutaminases

2014
EGFR-blockade with erlotinib reduces EGF and TGF-β2 expression and the actin-cytoskeleton which influences different aspects of cellular migration in lens epithelial cells.
    Current eye research, 2014, Volume: 39, Issue:10

    Topics: Actin Cytoskeleton; Cell Movement; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lens, Crystalline; Microscopy, Fluorescence; Protein Kinase Inhibitors; Quinazolines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Time-Lapse Imaging; Transforming Growth Factor beta2

2014
EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR.
    Oncotarget, 2014, Mar-15, Volume: 5, Issue:5

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Dynamins; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Expression Profiling; Gene Knockdown Techniques; Humans; Hydrazones; Lung Neoplasms; Male; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Quinazolines; rab GTP-Binding Proteins; Signal Transduction

2014
Quantification and kinetic analysis of Grb2-EGFR interaction on micro-patterned surfaces for the characterization of EGFR-modulating substances.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Coated Pits, Cell-Membrane; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; HeLa Cells; Humans; Microscopy, Fluorescence; Quinazolines; Tyrphostins

2014
Peroxisome proliferator-activated receptor γ agonist efatutazone impairs transforming growth factor β2-induced motility of epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer cells.
    Cancer science, 2014, Volume: 105, Issue:6

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Phosphatidylinositol 3-Kinases; PPAR gamma; Protein Kinase Inhibitors; Quinazolines; Smad2 Protein; Thiazolidinediones; Transforming Growth Factor beta2; Wound Healing

2014
Hepassocin activates the EGFR/ERK cascade and induces proliferation of L02 cells through the Src-dependent pathway.
    Cellular signalling, 2014, Volume: 26, Issue:10

    Topics: Cell Line; Cell Proliferation; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibrinogen; Gefitinib; Humans; Neoplasm Proteins; Phosphorylation; Quinazolines; Recombinant Proteins; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Transcriptional Activation

2014
MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:9

    Topics: Blotting, Western; Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Matrix Metalloproteinase 9; MicroRNAs; Models, Genetic; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins

2014
An in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction.
    Methods in molecular biology (Clifton, N.J.), 2014, Volume: 1172

    Topics: Animals; Biological Assay; Cell Communication; Cell Line, Tumor; Cell Movement; Coculture Techniques; Collagen Type I; Epidermal Growth Factor; Extracellular Matrix; Female; Fibronectins; Gefitinib; Humans; Macrophages; Mammary Glands, Human; Mice; Molecular Imaging; Quinazolines; Signal Transduction; Time-Lapse Imaging; Tyrphostins

2014
EGF receptor uses SOS1 to drive constitutive activation of NFκB in cancer cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Aug-12, Volume: 111, Issue:32

    Topics: Breast; Cell Line, Tumor; Cells, Cultured; Drug Resistance, Neoplasm; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Knockdown Techniques; Humans; Neoplasms; NF-kappa B; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; SOS1 Protein; Up-Regulation

2014
Epidermal growth factor inhibition, a novel pathway to prevent chronic allograft injury.
    Transplantation, 2014, Oct-27, Volume: 98, Issue:8

    Topics: Animals; Aorta; Chronic Disease; Epidermal Growth Factor; Erlotinib Hydrochloride; Graft Rejection; Immunohistochemistry; Kidney; Kidney Transplantation; Male; Quinazolines; Rats; Rats, Wistar; Transplantation, Homologous

2014
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.
    Science signaling, 2014, Aug-12, Volume: 7, Issue:338

    Topics: Animals; Carcinogenesis; Drug Delivery Systems; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Flow Cytometry; Fluorescent Antibody Technique; Glioblastoma; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Kaplan-Meier Estimate; Mice; NF-kappa B; Paracrine Communication; Protein Kinase C; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Necrosis Factor-alpha

2014
Label-free single cell kinetics of the invasion of spheroidal colon cancer cells through 3D Matrigel.
    Analytical chemistry, 2014, Sep-02, Volume: 86, Issue:17

    Topics: Biosensing Techniques; Cell Culture Techniques; Cell Movement; Collagen; Colonic Neoplasms; Drug Combinations; Epidermal Growth Factor; HT29 Cells; Humans; Kinetics; Laminin; Microscopy; Piperidines; Protein Kinase Inhibitors; Proteoglycans; Quinazolines; Spheroids, Cellular

2014
Plasticity of mammary cell boundaries governed by EGF and actin remodeling.
    Cell reports, 2014, Sep-25, Volume: 8, Issue:6

    Topics: Actin Cytoskeleton; Actins; Cadherins; Cell Differentiation; Cell Line; Desmosomes; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Mammary Glands, Human; Protein Kinase Inhibitors; Quinazolines; Shear Strength; Signal Transduction

2014
The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling.
    Oncotarget, 2014, Oct-30, Volume: 5, Issue:20

    Topics: Caco-2 Cells; Cell Line, Tumor; Colonic Neoplasms; Epidermal Growth Factor; ErbB Receptors; Gefitinib; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; MAP Kinase Signaling System; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Quinazolines; Receptor-Like Protein Tyrosine Phosphatases, Class 3; RNA, Messenger; Signal Transduction; src-Family Kinases

2014
EGF promotes mammalian cell growth by suppressing cellular senescence.
    Cell research, 2015, Volume: 25, Issue:1

    Topics: Animals; Cell Line; Cell Proliferation; Cells, Cultured; Cellular Senescence; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Quinazolines

2015
EGF‑stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib‑resistant human lung cancer cell line.
    International journal of oncology, 2015, Volume: 46, Issue:4

    Topics: Cell Line, Tumor; Cell Membrane; Drug Resistance, Neoplasm; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Knockdown Techniques; Humans; Lung Neoplasms; Monensin; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Sorting Nexins

2015
TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:7

    Topics: Animals; Apoptosis; Atrophy; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Interferon-gamma; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Parenteral Nutrition, Total; Quinazolines; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2015
Modulation of Regorafenib effects on HCC cell lines by epidermal growth factor.
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epidermal Growth Factor; Erlotinib Hydrochloride; Hep G2 Cells; Humans; Liver Neoplasms; MAP Kinase Signaling System; Niacinamide; Phenylurea Compounds; Phosphorylation; Pyridines; Quinazolines; Sorafenib

2015
Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Adolescent; Air; Asthma; Bronchi; Cell Count; Cell Differentiation; Cell Proliferation; Cells, Cultured; Child; Child, Preschool; Electric Impedance; Epidermal Growth Factor; Female; Goblet Cells; Humans; Infant; Male; Models, Biological; Mucin 5AC; Quinazolines; RNA, Messenger; Tyrphostins

2015
Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Aug-04, Volume: 112, Issue:31

    Topics: Animals; Cell Line; Cytokines; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gene Silencing; Humans; Lipopolysaccharides; MAP Kinase Kinase Kinases; Mice; Myeloid Differentiation Factor 88; NF-kappa B; Phosphorylation; Protective Agents; Proto-Oncogene Mas; Quinazolines; Signal Transduction; src-Family Kinases; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2015
Rapidly activated epidermal growth factor receptor mediates lipopolysaccharide-triggered migration of microglia.
    Neurochemistry international, 2015, Volume: 90

    Topics: Animals; Cell Movement; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Lipopolysaccharides; MAP Kinase Signaling System; Microglia; Phosphorylation; Quinazolines; Rats, Wistar; Tyrphostins

2015
Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II.
    Journal of cellular and molecular medicine, 2016, Volume: 20, Issue:3

    Topics: Angiotensin II; Animals; Cardiomegaly; Cardiotonic Agents; Cell Line; Drug Evaluation, Preclinical; Epidermal Growth Factor; ErbB Receptors; Gene Knockdown Techniques; Mice, Inbred C57BL; Myocytes, Cardiac; Quinazolines; Rats; Tyrphostins

2016
Inhibitory effect of luteolin on the proliferation of human breast cancer cell lines induced by epidermal growth factor.
    Sheng li xue bao : [Acta physiologica Sinica], 2016, Feb-25, Volume: 68, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Luteolin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Quinazolines; Tyrphostins

2016
Inhibition of the Ras-ERK pathway in mitotic COS7 cells is due to the inability of EGFR/Raf to transduce EGF signaling to downstream proteins.
    Oncology reports, 2016, Volume: 35, Issue:6

    Topics: Animals; Caveolins; Cell Line; Chlorocebus aethiops; Clathrin; COS Cells; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; MAP Kinase Signaling System; Nocodazole; Phosphorylation; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Quinazolines; raf Kinases; Shc Signaling Adaptor Proteins; Tetradecanoylphorbol Acetate; Tyrphostins

2016
Epidermal growth factor-like repeats of tenascin-C-induced constriction of cerebral arteries via activation of epidermal growth factor receptors in rats.
    Brain research, 2016, 07-01, Volume: 1642

    Topics: Animals; Cerebral Arteries; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Male; Models, Animal; Quinazolines; Random Allocation; Rats, Sprague-Dawley; Recombinant Proteins; Tenascin; Tyrphostins; Vasoconstriction; Vasospasm, Intracranial

2016
Role of EGF receptor ligands in TCDD-induced EGFR down-regulation and cellular proliferation.
    Chemico-biological interactions, 2016, Jun-25, Volume: 253

    Topics: Amphiregulin; Cell Proliferation; Cells, Cultured; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Ligands; Polychlorinated Dibenzodioxins; Protein Binding; Quinazolines; Transforming Growth Factor alpha

2016
Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling.
    Molecular cell, 2016, 05-05, Volume: 62, Issue:3

    Topics: Acyltransferases; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cysteine; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gefitinib; GRB2 Adaptor Protein; HEK293 Cells; Humans; Lipoylation; Mass Spectrometry; Mice; Mutation; NIH 3T3 Cells; Protein Conformation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Transport; Proteolysis; Quinazolines; RNA Interference; Signal Transduction; Structure-Activity Relationship; Transfection

2016
Bruton's Tyrosine Kinase Inhibitors Prevent Therapeutic Escape in Breast Cancer Cells.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:9

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Epidermal Growth Factor; Female; Gene Expression; Humans; Lapatinib; MAP Kinase Signaling System; Mice; Neuregulin-1; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays

2016
Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer.
    BMC cancer, 2016, 06-06, Volume: 16

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dihydrouracil Dehydrogenase (NADP); Drug Resistance, Neoplasm; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Fluorouracil; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mutation; Plicamycin; Quinazolines; Signal Transduction; Sp1 Transcription Factor

2016
IL-17E synergizes with EGF and confers in vitro resistance to EGFR-targeted therapies in TNBC cells.
    Oncotarget, 2016, Aug-16, Volume: 7, Issue:33

    Topics: Cell Line, Tumor; Cell Nucleus; Drug Resistance, Neoplasm; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Humans; Interleukin-17; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Triple Negative Breast Neoplasms

2016
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.
    Nature communications, 2016, 08-30, Volume: 7

    Topics: Animals; Antineoplastic Agents; B7-H1 Antigen; beta-Transducin Repeat-Containing Proteins; Breast; Breast Neoplasms; Cell Line, Tumor; Epidermal Growth Factor; Female; Gefitinib; Glycogen Synthase Kinase 3 beta; Glycosylation; Humans; Immunologic Surveillance; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Phosphorylation; Programmed Cell Death 1 Receptor; Protein Stability; Quinazolines; T-Lymphocytes; Tumor Escape; Ubiquitination; Xenograft Model Antitumor Assays

2016
EGF Induced RET Inhibitor Resistance in CCDC6-RET Lung Cancer Cells.
    Yonsei medical journal, 2017, Volume: 58, Issue:1

    Topics: Adenocarcinoma; Cell Line, Tumor; Cetuximab; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; fms-Like Tyrosine Kinase 3; Gefitinib; Gene Rearrangement; Hepatocyte Growth Factor; Humans; Indoles; Lung Neoplasms; MAP Kinase Signaling System; Mutation; Niacinamide; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Pyrroles; Quinazolines; RNA, Small Interfering; Signal Transduction; Sorafenib; Sunitinib

2017
Novel multi-targeted ErbB family inhibitor afatinib blocks EGF-induced signaling and induces apoptosis in neuroblastoma.
    Oncotarget, 2017, Jan-03, Volume: 8, Issue:1

    Topics: Afatinib; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Doxorubicin; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Mice; Mice, Nude; Neuroblastoma; Quinazolines; Radiation-Sensitizing Agents; Signal Transduction; Xenograft Model Antitumor Assays

2017
Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.
    Biochemistry, 2017, Jan-10, Volume: 56, Issue:1

    Topics: Allosteric Regulation; Amino Acid Motifs; Animals; Catalytic Domain; CHO Cells; Cricetinae; Cricetulus; Drug Resistance; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Hydrophobic and Hydrophilic Interactions; Immunoblotting; Lapatinib; Molecular Dynamics Simulation; Mutation; Protein Kinase Inhibitors; Protein Structure, Secondary; Quinazolines

2017
Quantifying receptor trafficking and colocalization with confocal microscopy.
    Methods (San Diego, Calif.), 2017, 02-15, Volume: 115

    Topics: Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; HeLa Cells; Humans; Hydrazones; Luminescent Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Protein Transport; Quinazolines; rab5 GTP-Binding Proteins; Recombinant Fusion Proteins; Red Fluorescent Protein; Transformation, Genetic; Tyrphostins

2017
Gefitinib enhances radiotherapeutic effects of
    Nuclear medicine and biology, 2017, Volume: 48

    Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Iodine Radioisotopes; Mice; Mice, Nude; Protein Transport; Quinazolines; Radiation Tolerance; Radiochemistry; Tissue Distribution

2017
Exosome production and its regulation of EGFR during wound healing in renal tubular cells.
    American journal of physiology. Renal physiology, 2017, 06-01, Volume: 312, Issue:6

    Topics: Aniline Compounds; Animals; Benzylidene Compounds; Cell Line; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Exosomes; Gefitinib; Kidney Tubules; Mice; Polyenes; Polyunsaturated Alkamides; Quinazolines; Signal Transduction; Time Factors; Wound Healing

2017
Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.
    Oncology reports, 2017, Volume: 37, Issue:6

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cetuximab; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Indoles; Mouth Neoplasms; Phosphatidylinositol 3-Kinases; Piperazines; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pseudopodia; Quinazolines; Signal Transduction; Sulfonamides; Tyrphostins

2017
Epithelial growth factor receptor expression influences 5-ALA induced glioblastoma fluorescence.
    Journal of neuro-oncology, 2017, Volume: 133, Issue:3

    Topics: Aminolevulinic Acid; Astrocytes; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Fluorescent Dyes; Gefitinib; Gene Expression; Glioblastoma; Heme Oxygenase-1; Humans; Protein Kinase Inhibitors; Quinazolines; RNA, Messenger

2017
Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells.
    Cell death and differentiation, 2017, Volume: 24, Issue:11

    Topics: Blood Proteins; Cell Line, Tumor; Cell Membrane; Endocytosis; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Galectin 3; Galectins; Humans; Lapatinib; MAP Kinase Signaling System; Mucin-1; Mutation; Neoplasms; Protein Binding; Protein Domains; Protein Kinase Inhibitors; Protein Multimerization; Quinazolines

2017
Epidermal Growth Factor Receptor activation promotes ADA3 acetylation through the AKT-p300 pathway.
    Cell cycle (Georgetown, Tex.), 2017, Aug-18, Volume: 16, Issue:16

    Topics: Acetylation; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gene Knockdown Techniques; Humans; Lapatinib; Models, Biological; Mutation; p300-CBP Transcription Factors; Phosphorylation; Protein Stability; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Transcription Factors; Ubiquitination

2017
Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death.
    Journal of ovarian research, 2018, Feb-05, Volume: 11, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; beta-D-Galactoside alpha 2-6-Sialyltransferase; Cell Line, Tumor; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Gene Expression; Gene Knockdown Techniques; Humans; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteome; Proteomics; Quinazolines; Sialyltransferases; Signal Transduction

2018
Role of GPCR (mu-opioid)-receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II).
    Pain, 2018, Volume: 159, Issue:5

    Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Hyperalgesia; Male; Nociceptors; Pain Threshold; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Signal Transduction; Tyrphostins

2018
Epidermal Growth Factor Receptor Regulation of Ewing Sarcoma Cell Function.
    Oncology, 2018, Volume: 94, Issue:6

    Topics: Bone Neoplasms; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; G1 Phase Cell Cycle Checkpoints; Humans; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Sarcoma, Ewing; Signal Transduction; Tumor Suppressor Protein p53; Tyrphostins

2018
EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in non‑small cell lung cancer cells.
    Oncology reports, 2018, Volume: 40, Issue:1

    Topics: A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Molecular Targeted Therapy; Quinazolines; Telomerase; Tyrphostins

2018
Transcriptional repressor Kaiso promotes epithelial to mesenchymal transition and metastasis in prostate cancer through direct regulation of miR-200c.
    Cancer letters, 2018, 09-01, Volume: 431

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Epidermal Growth Factor; Epithelial-Mesenchymal Transition; ErbB Receptors; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Neoplasm Transplantation; Prostatic Neoplasms; Quinazolines; Transcription Factors

2018
Synthesis and antitumor activity of novel 6,7,8-trimethoxy N-aryl-substituted-4-aminoquinazoline derivatives.
    Bioorganic & medicinal chemistry letters, 2018, 08-01, Volume: 28, Issue:14

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epidermal Growth Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Structure; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship

2018
Exposure to EGF and 17β‑estradiol irreversibly affects the proliferation and transformation of MCF7 cells but is not sufficient to promote tumor growth in a xenograft mouse model upon withdrawal of exposure.
    International journal of molecular medicine, 2018, Volume: 42, Issue:3

    Topics: Animals; Benzamides; Carcinogenesis; Cell Proliferation; Cell Transformation, Neoplastic; Dioxoles; Epidermal Growth Factor; Estradiol; Female; Gefitinib; Humans; MCF-7 Cells; Mice, SCID; Models, Biological; Neoplastic Stem Cells; Phenotype; Quinazolines; Spheroids, Cellular; Tamoxifen; Xenograft Model Antitumor Assays

2018
FOS, a Critical Downstream Mediator of PGR and EGF Signaling Necessary for Ovulatory Prostaglandins in the Human Ovary.
    The Journal of clinical endocrinology and metabolism, 2018, 11-01, Volume: 103, Issue:11

    Topics: Adult; Benzophenones; Cells, Cultured; Chorionic Gonadotropin; Dinoprostone; Epidermal Growth Factor; Female; Humans; Isoxazoles; Mifepristone; Ovarian Follicle; Ovulation; Primary Cell Culture; Progesterone; Proto-Oncogene Proteins c-fos; Quinazolines; Receptors, Progesterone; RNA, Small Interfering; Signal Transduction; Tyrphostins; Up-Regulation

2018
Label-free imaging of epidermal growth factor receptor-induced response in single living cells.
    The Analyst, 2018, Nov-07, Volume: 143, Issue:21

    Topics: Cell Line, Tumor; Cytochalasin B; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Microscopy, Fluorescence; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Single-Cell Analysis; Surface Plasmon Resonance; Tyrphostins

2018
Differences in embryonic gene expression and quality indicate the benefit of epidermal growth factor receptor inhibitor during prematuration to improve competence in bovine oocytes.
    Reproduction in domestic animals = Zuchthygiene, 2019, Volume: 54, Issue:4

    Topics: Animals; Cattle; Embryo, Mammalian; Embryonic Development; Enzyme Inhibitors; Epidermal Growth Factor; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; In Vitro Oocyte Maturation Techniques; Quinazolines; Tyrphostins

2019
Sialidase Attenuates Epidermal Growth Factor Response and Abolishes Antiproliferative Effects of Erlotinib in A549Alveolar Epithelial Cells.
    Advances in experimental medicine and biology, 2019, Volume: 1153

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epidermal Growth Factor; Epithelial Cells; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Neuraminidase; Protein Kinase Inhibitors; Quinazolines

2019
Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction.
    American journal of hypertension, 2020, 08-04, Volume: 33, Issue:8

    Topics: Animals; Cell Movement; Cell Proliferation; Crown Ethers; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Hypertension, Pulmonary; In Vitro Techniques; MAP Kinase Signaling System; Microfilament Proteins; Monocrotaline; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteopontin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Quinazolines; Rats; Signal Transduction; Vascular Remodeling; Ventricular Function, Right; Ventricular Pressure; Vimentin

2020
Morphine Prevents Ischemia/Reperfusion-Induced Myocardial Mitochondrial Damage by Activating δ-opioid Receptor/EGFR/ROS Pathway.
    Cardiovascular drugs and therapy, 2022, Volume: 36, Issue:5

    Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Mitochondria, Heart; Morphine; Myocytes, Cardiac; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Reactive Oxygen Species; Receptors, Opioid; Reperfusion; Reperfusion Injury; RNA, Small Interfering; Superoxides; Tyrphostins

2022
A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation.
    Nature communications, 2022, 01-10, Volume: 13, Issue:1

    Topics: Animals; Chromatography, Affinity; Class I Phosphatidylinositol 3-Kinases; Epidermal Growth Factor; Exosomes; Gene Expression; HEK293 Cells; HeLa Cells; Humans; Male; Mass Spectrometry; Metabolome; Mice; PC-3 Cells; Phosphatidylinositols; Prostate; Prostatic Neoplasms; PTEN Phosphohydrolase; Pyrimidines; Quinazolines; Stereoisomerism

2022