quinazolines has been researched along with dihydrofolate in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goldman, ID; Seither, RL; Trent, DF | 2 |
| Goldman, ID; Mikulecky, DC; Rape, TJ; Seither, RL; Trent, DF | 1 |
| Beechem, JM; Bradrick, TD; Howell, EE | 1 |
| Appleman, JR; Spencer, HT; Villafranca, JE | 1 |
| Assaraf, YG; Drori, S; Jansen, G; Mauritz, R; Peters, GJ | 1 |
| Anderson, KS; Atreya, CE; Chang, SY; Johnson, EF; Liang, PH; Williamson, J | 1 |
7 other study(ies) available for quinazolines and dihydrofolate
| Article | Year |
|---|---|
Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Flow Cytometry; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thermodynamics; Trimetrexate; Tumor Cells, Cultured | 1991 |
Compartmentation of intracellular folates. Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate.
Topics: Animals; Cell Compartmentation; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Mitochondria; Quinazolines; Tetrahydrofolates; Trimetrexate; Tumor Cells, Cultured | 1991 |
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
Topics: Animals; Computer Simulation; Deoxyuridine; Floxuridine; Folic Acid; Folic Acid Antagonists; Formates; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimidines; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate | 1989 |
Unusual binding stoichiometries and cooperativity are observed during binary and ternary complex formation in the single active pore of R67 dihydrofolate reductase, a D2 symmetric protein.
Topics: Allosteric Regulation; Binding Sites; Calorimetry; Fluorescence Polarization; Folic Acid; Kinetics; Ligands; NADP; Protein Binding; Quinazolines; R Factors; Tetrahydrofolate Dehydrogenase | 1996 |
Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
Topics: Catalysis; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Ligands; Molecular Structure; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Spectrometry, Fluorescence; Spectrophotometry; Tetrahydrofolates; Thermodynamics; Thymidine Monophosphate; Thymidylate Synthase | 1997 |
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Blotting, Northern; Blotting, Southern; Blotting, Western; Carrier Proteins; Cell Division; Cell Membrane; Chlorides; DNA Mutational Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Exons; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Kinetics; Leucovorin; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mutagenesis, Site-Directed; Mutation; Polymorphism, Single-Stranded Conformational; Protein Structure, Secondary; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins; Reduced Folate Carrier Protein; Thymidylate Synthase; Time Factors; Transfection; Trimetrexate; Tumor Cells, Cultured | 2000 |
Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.
Topics: Animals; Binding Sites; Catalysis; Crystallization; Enzyme Stability; Fluorodeoxyuridylate; Folic Acid; Hydrocarbons; Kinetics; Leishmania major; Methane; Models, Molecular; Molecular Structure; Multienzyme Complexes; Mutagenesis, Site-Directed; NADP; Quinazolines; Spectrophotometry; Static Electricity; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase | 2003 |