Page last updated: 2024-08-21

quinazolines and cyclosporine

quinazolines has been researched along with cyclosporine in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (10.00)	18.2507
2000's	2 (10.00)	29.6817
2010's	16 (80.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dreslin, JA; Grizzuti, K; Gros, P; Kajiji, S	1
Ben-Bassat, H; Klein, BY; Rojansky, N; Stekelenburg, J	1
Cetkovic-Cvrlje, M; Dragt, AL; Uckun, FM	1
Catania, C; Curigliano, G; de Braud, F; De Carlis, L; De Pas, T; Locatelli, M; Lorizzo, K; Pelosi, G; Spitaleri, G; Toffalorio, F	1
Beerli, C; Bruns, C; Burkhart, C; Metzler, B; Morris, RE; Pally, C; Wagner, J; Weckbecker, G; Wieczorek, G	1
Cooper, JE; Wiseman, AC	1
Grenet, O; Kovarik, JM; Seiberling, M; Sfikas, N; Slade, A; Stitah, S; Straube, F; Vitaliti, A; Winter, S	1
Budde, K; Glander, P; Mashreghi, MF; Matz, M; Naik, M; Neumayer, HH	1
Chen, CY; Chen, KT; Chen, TL; Chuang, YH; Chung, JG; Hour, MJ; Kuo, SC; Lu, CC; Yang, JS	1
Becker, T; Chicano Wust, I; Ciesek, S; Heidrich, B; Helfritz, FA; Manns, MP; Pietschmann, T; Rohrmann, K; Schulze, A; Steinmann, E; Urban, S; von Hahn, T	1
Todo, S; Yamashita, K	1
Audet, M; Beerli, C; Bigaud, M; Blancher, A; Heusser, C; Morris, RE; Wagner, J; Wieczorek, G	1
Klintmalm, GB; Ruiz, R	1
Baan, C; de Weerd, A; Kho, M; Kraaijeveld, R; Weimar, W; Zuiderwijk, J	1
Bossart, W; Etter, A; Fehr, T; Hässig, A; Müller, N; Roos, M; Schiesser, M; Wüthrich, RP	1
de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M	1
Han, W; Jiang, L; Jing, J; Jing, Z; Pan, H; Shou, J; Sui, X; Xie, J; Yao, J; You, L	1
Huo, X; Liu, K; Liu, Q; Liu, Z; Ma, X; Meng, Q; Sun, H; Sun, P; Wang, C; Yang, X; Zhang, Y	1
Abumiya, M; Guo, YM; Takahashi, N; Ubukawa, K; Yamashita, T	1
Adedoyin, A; Cho, CR; Iwamoto, M; Kraft, WK; Levine, V; Liu, F; Macha, S; Marshall, W; McCrea, JB; Menzel, K; Panebianco, D; Stoch, SA; Yoon, E; Zhao, T	1

Reviews

3 review(s) available for quinazolines and cyclosporine

Article	Year
Novel immunosuppressive agents in kidney transplantation. Clinical nephrology, 2010, Volume: 73, Issue:5 Topics: Abatacept; Alefacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cyclosporine; Everolimus; Graft Rejection; Graft Survival; Humans; Immunoconjugates; Immunosuppressive Agents; Kidney Transplantation; Piperidines; Pyrimidines; Pyrroles; Quinazolines; Recombinant Fusion Proteins; Sirolimus	2010
Evaluation of the novel protein kinase C inhibitor sotrastaurin as immunosuppressive therapy after renal transplantation. Expert opinion on drug metabolism & toxicology, 2011, Volume: 7, Issue:1 Topics: Calcineurin Inhibitors; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cyclosporine; Drug Evaluation; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Mycophenolic Acid; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Sirolimus; Tacrolimus; Treatment Outcome	2011
Renal-sparing regimens employing new agents. Current opinion in organ transplantation, 2012, Volume: 17, Issue:6 Topics: Abatacept; Calcineurin Inhibitors; Cyclosporine; Everolimus; Graft Rejection; Humans; Immunoconjugates; Immunosuppressive Agents; Kidney; Kidney Transplantation; Mycophenolic Acid; Pyrroles; Quinazolines; Sirolimus; TOR Serine-Threonine Kinases	2012

Trials

3 trial(s) available for quinazolines and cyclosporine

Article	Year
Sotrastaurin and cyclosporine drug interaction study in healthy subjects. Biopharmaceutics & drug disposition, 2010, Volume: 31, Issue:5-6 Topics: Adult; Biomarkers, Pharmacological; Cyclosporine; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Humans; Lymphocyte Activation; Male; Pyrroles; Quinazolines; T-Lymphocytes	2010
The protein kinase C inhibitor sotrastaurin allows regulatory T cell function. Clinical and experimental immunology, 2014, Volume: 175, Issue:2 Topics: Adult; CD4 Antigens; Cell Proliferation; Cyclosporine; Female; Flow Cytometry; Forkhead Transcription Factors; Humans; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Kidney Transplantation; Lymphocyte Count; Lymphocyte Culture Test, Mixed; Male; Middle Aged; NF-kappa B; Phosphorylation; Protein Kinase C; Pyrroles; Quinazolines; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes, Regulatory	2014
Pharmacokinetic Drug-Drug Interactions Between Letermovir and the Immunosuppressants Cyclosporine, Tacrolimus, Sirolimus, and Mycophenolate Mofetil. Journal of clinical pharmacology, 2019, Volume: 59, Issue:10 Topics: Acetates; Adolescent; Adult; Aged; Antiviral Agents; Area Under Curve; Cyclosporine; Double-Blind Method; Drug Interactions; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Middle Aged; Mycophenolic Acid; Quinazolines; Sirolimus; Tacrolimus; Young Adult	2019

Other Studies

14 other study(ies) available for quinazolines and cyclosporine

Article	Year
Structurally distinct MDR modulators show specific patterns of reversal against P-glycoproteins bearing unique mutations at serine939/941. Biochemistry, 1994, May-03, Volume: 33, Issue:17 Topics: Amino Acid Sequence; Animals; Cell Survival; CHO Cells; Clone Cells; Cricetinae; Cyclosporine; Dibenzocycloheptenes; Drug Resistance; Glycoproteins; Isoquinolines; Mice; Phenylalanine; Point Mutation; Quinazolines; Quinolines; Recombinant Proteins; Serine; Transfection; Vinblastine	1994
Opposing effects of cyclosporin A and tyrphostin AG-1478 indicate a role for Src protein in the cellular control of mineralization. Journal of cellular biochemistry, 1998, Oct-01, Volume: 71, Issue:1 Topics: Animals; Calcification, Physiologic; Cell Differentiation; Cells, Cultured; Cyclosporine; Dexamethasone; Enzyme Inhibitors; Female; Phosphorylation; Proteins; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rats; Rats, Inbred Strains; Stromal Cells; Tyrosine; Tyrphostins	1998
Prevention of islet allograft rejection in diabetic mice by targeting Janus Kinase 3 with 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (JANEX-1). Arzneimittel-Forschung, 2003, Volume: 53, Issue:9 Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Enzyme Inhibitors; Graft Rejection; Immunosuppressive Agents; Islets of Langerhans Transplantation; Janus Kinase 3; Major Histocompatibility Complex; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Protein-Tyrosine Kinases; Quinazolines	2003
Erlotinib combined with cyclosporine in a liver-transplant recipient with epidermal growth factor receptor-mutated non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2009, Volume: 4, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cyclosporine; ErbB Receptors; Erlotinib Hydrochloride; Humans; Liver Transplantation; Lung Neoplasms; Male; Middle Aged; Mutation; Quinazolines	2009
Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720. Transplant international : official journal of the European Society for Organ Transplantation, 2010, May-01, Volume: 23, Issue:5 Topics: Animals; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Everolimus; Fingolimod Hydrochloride; Heart Transplantation; Immunosuppressive Agents; Male; Propylene Glycols; Protein Kinase C; Pyrroles; Quinazolines; Rats; Rats, Inbred Lew; Rats, Wistar; Sirolimus; Sphingosine	2010
The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells. European journal of medicinal chemistry, 2011, Volume: 46, Issue:7 Topics: Acetylcysteine; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; Caspases; Cell Line, Tumor; Cyclosporine; Cytochromes c; DNA Fragmentation; Fas Ligand Protein; fas Receptor; Fas-Associated Death Domain Protein; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; Osteoblasts; Quinazolines; Reactive Oxygen Species; Signal Transduction	2011
The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus. PloS one, 2011, Volume: 6, Issue:9 Topics: Calcineurin; Calcineurin Inhibitors; Cell Line, Tumor; Cyclosporine; Hepacivirus; Hepatitis B virus; Humans; Immunosuppressive Agents; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; RNA, Viral; Virus Internalization; Virus Replication	2011
Sotrastaurin, a new selective protein kinase C inhibitor, on the way. Transplantation, 2012, Jan-27, Volume: 93, Issue:2 Topics: Animals; Cyclosporine; Graft Survival; Humans; Kidney Transplantation; Pyrroles; Quinazolines	2012
Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts. Transplantation, 2012, Jan-27, Volume: 93, Issue:2 Topics: Animals; Cyclosporine; Drug Synergism; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Activation; Macaca fascicularis; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; T-Lymphocytes; Time Factors; Transplantation, Homologous	2012
Association of BK viremia with human leukocyte antigen mismatches and acute rejection, but not with type of calcineurin inhibitor. Transplant infectious disease : an official journal of the Transplantation Society, 2014, Volume: 16, Issue:1 Topics: Adult; Aged; Allografts; Antibodies, Monoclonal; Azathioprine; Basiliximab; BK Virus; Cohort Studies; Cyclosporine; Female; Glomerular Filtration Rate; Graft Rejection; Histocompatibility; HLA Antigens; Humans; Immunosuppressive Agents; Kidney Diseases; Kidney Transplantation; Logistic Models; Male; Middle Aged; Multivariate Analysis; Mycophenolic Acid; Polyomavirus Infections; Proteinuria; Pyrroles; Quinazolines; Recombinant Fusion Proteins; Tacrolimus; Tumor Virus Infections; Viremia	2014
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:5 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cyclosporins; In Vitro Techniques; Intestinal Mucosa; Isoquinolines; Ketoconazole; Male; Quinazolines; Quinidine; Rats, Wistar; Rhodamine 123; Verapamil	2015
Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3. Cancer letters, 2016, 08-28, Volume: 379, Issue:1 Topics: A549 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cyclosporine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Humans; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; NFATC Transcription Factors; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays	2016
P-gp is involved in the intestinal absorption and biliary excretion of afatinib in vitro and in rats. Pharmacological reports : PR, 2018, Volume: 70, Issue:2 Topics: Adenosine Triphosphatases; Afatinib; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Biological Transport; Caco-2 Cells; Cell Line, Tumor; Cyclosporine; Hepatobiliary Elimination; Hepatocytes; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Quinazolines; Rats; Rats, Wistar; Verapamil	2018
Pharmacokinetics of Tacrolimus Coadministered With Letermovir in Allogeneic Hematopoietic Stem Cell Transplantation Patients. Clinical pharmacology in drug development, 2019, Volume: 8, Issue:3 Topics: Acetates; Cyclosporine; Healthy Volunteers; Hematopoietic Stem Cell Transplantation; Humans; Quinazolines; Tacrolimus	2019