quinazolines has been researched along with cyclic gmp in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (26.32) | 18.7374 |
| 1990's | 13 (34.21) | 18.2507 |
| 2000's | 10 (26.32) | 29.6817 |
| 2010's | 4 (10.53) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Hess, HJ | 1 |
| Chasin, M; Harris, DN | 1 |
| Jorgensen, R; Sands, H | 1 |
| Bühler, FR; Erne, P; Mittelholzer, E; Resink, TJ; Rogg, H | 1 |
| Shida, T; Yanagihara, Y | 1 |
| Kane, KA; Morcillo-Sanchez, EJ; Parratt, JR; Rodger, IW; Shahid, M | 1 |
| Houslay, MD; Price, B; Pyne, NJ | 1 |
| Kambayashi, J; Kawasaki, T; Mori, T; Sakon, M; Suga, K | 1 |
| Ishihara, Y; Kitamura, S; Kosaka, K; Yotsumoto, H | 1 |
| Hayashi, H; Ogasawara, B; Ogawa, K; Sassa, H | 1 |
| Adachi, H; Saeki, T; Saito, I; Souda, S; Takase, Y; Yoshitake, S | 1 |
| Forssmann, WG; Jonas, U; Meyer, M; Schulz-Knappe, P; Stief, CG; Taher, A; Truss, M | 1 |
| Adachi, H; Saeki, T; Saito, I; Souda, S; Takase, Y; Watanabe, N | 1 |
| Fujimoto, M; Saeki, T; Saito, I; Takase, Y | 1 |
| Clarke, W; Cohen, AH; Fouty, B; Hanson, K; McMurty, IF; Morris, K; Rodman, DM | 1 |
| Becker, AJ; Forssmann, WG; Jonas, U; Meyer, M; Schulz-Knappe, P; Stief, CG; Taher, A; Truss, M; Uckert, S | 1 |
| Matsumori, A; Nose, Y; Ono, K; Sasayama, S; Sato, Y; Shioi, T | 1 |
| Hung, WC; Lee, YM; Sheu, JR; Yen, MH | 1 |
| Forssmann, WG; Jonas, U; Meyer, M; Stief, CG; Taher, A | 1 |
| Artemyev, NO; Cote, RH; D'Amours, MR; Granovsky, AE | 1 |
| Fukuchi, Y; Kira, S; Muramatsu, M; Ohnishi, M; Oka, M; Sato, K | 1 |
| Chen, CF; Huang, YT; Lin, LC; Pang, PK; Shan, J; Wang, GJ; Wu, XC | 1 |
| Dukarm, RC; Morin, FC; Perry, BJ; Russell, JA; Steinhorn, RH | 1 |
| Bischoff, E; Jonas, U; Kühn, R; Lietz, B; Schramm, M; Stief, CG; Truss, MC; Uckert, S | 1 |
| Ahnen, D; Fetter, J; Li, H; Liu, L; Pamukcu, R; Piazza, GA; Sperl, G; Thompson, WJ; Zhu, B | 1 |
| Andersson, K; Fujiwara, M; Persson, K | 1 |
| Potter, DE; Thompson, WJ; Zhou, L | 1 |
| Casadei, B; Musialek, P; Paterson, DJ; Rigg, L; Terrar, DA | 1 |
| Hirose, R; Ichimura, M; Irie, J; Nomoto, Y; Ohno, T; Okumura, H; Onoda, Y; Takai, H; Yoshimatsu, A | 1 |
| Hayakawa, H; Hirata, Y; Homma, Y; Horie, S; Kawabe, K; Kitamura, T; Minowada, S; Nagai, R; Nagata, D; Nishimatsu, H; Ohta, N; Satonaka, H; Suzuki, E; Takeuchi, T | 1 |
| Delbecque, JP; Gautron, F; Manière, G; Vanhems, E | 1 |
| Azegami, Y; Kaneda, T; Nakajyo, S; Shimizu, K; Urakawa, N; Yamamoto, H | 1 |
| Allen, MP; Chappie, TA; Estep, KG; Fox, CB; Humphrey, JM; Lebel, LA; Liras, S; Marr, ES; Menniti, FS; Pandit, J; Schmidt, CJ; Tu, M; Williams, RD; Yang, FV | 1 |
| Freudzon, M; Jaffe, LA; Nikolaev, VO; Norris, RP | 1 |
| Chen, Q; Liu, W; Wang, C; Xia, G; Yang, Y; Zhang, M; Zhang, W | 1 |
| Kanamitsu, K; Kusuhara, H; Schuetz, JD; Sugiyama, Y; Takeuchi, K | 1 |
| Chen, XP; Hou, HH; Lin, SX; Sun, AS; Xu, Y; Zhang, F; Zhang, JY | 1 |
| Chatturong, U; Chootip, K; Demougeot, C; Gleeson, MP; Ingkaninan, K; Konsue, A; Martin, H; Sermsenaphorn, S; Somarin, T; Temkitthawon, P; Totoson, P | 1 |
1 review(s) available for quinazolines and cyclic gmp
| Article | Year |
|---|---|
Inhibitory and activators of cyclic nucleotide phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antidepressive Agents, Tricyclic; Catecholamines; Cerebral Cortex; Chelating Agents; Cyclic GMP; Enzyme Activation; Guinea Pigs; Imidazoles; Insulin; Kinetics; Nucleotides, Cyclic; Organ Specificity; Papaverine; Phosphoric Diester Hydrolases; Pyrazoles; Pyridines; Quinazolines; Species Specificity; Sulfonylurea Compounds; Xanthines | 1976 |
37 other study(ies) available for quinazolines and cyclic gmp
| Article | Year |
|---|---|
Prazosin: biochemistry and structure-activity studies.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antihypertensive Agents; Blood Pressure; Cyclic AMP; Cyclic GMP; Depression, Chemical; Dogs; In Vitro Techniques; Male; Piperazines; Quinazolines; Rats; Structure-Activity Relationship; Vascular Resistance | 1975 |
Effects of prazosin on cyclic nucleotide content and blood pressure of the spontaneously hypertensive rat.
Topics: Animals; Aorta; Blood Pressure; Cyclic AMP; Cyclic GMP; Hypertension; In Vitro Techniques; Muscle, Smooth; Myocardium; Prazosin; Quinazolines; Rats | 1979 |
Vasodilating agents and platelet function: intracellular free calcium concentration, cyclic nucleotides, and shape-change response.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Atrial Natriuretic Factor; Blood Platelets; Calcium; Cyclic AMP; Cyclic GMP; Humans; Pyridines; Quinazolines; Thrombin; Vasodilator Agents; Vasopressins | 1986 |
Immunopharmacological actions of the new antiallergic drug 11-oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid. Effects on type I hypersensitivity reactions in human leukocytes and in human and monkey lungs.
Topics: Animals; Calcimycin; Cyclic AMP; Cyclic GMP; Histamine Release; Humans; Hypersensitivity; Leukocytes; Lung; Macaca; Mites; Quinazolines | 1986 |
The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat.
Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Arrhythmias, Cardiac; Bucladesine; Coronary Disease; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Heart; Male; Myocardium; Quinazolines; Rats; Rats, Inbred Strains | 1985 |
Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be inhibited by compounds which exert positive inotropic actions in cardiac tissue.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Amrinone; Animals; Carbamates; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Dogs; Kinetics; Milrinone; Myocardium; Peptide Hydrolases; Pyridazines; Pyridones; Quinazolines; Trypsin | 1987 |
Phosphorylation of phosphoinositides in human platelets.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminoquinolines; Blood Platelets; Bucladesine; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Epoprostenol; Humans; Phosphatidic Acids; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphorus Radioisotopes; Phosphorylation; Quinazolines | 1986 |
The potentiating effect of an alpha-adrenergic blocking agent (E-643) on the action of bronchodilators.
Topics: Adrenergic alpha-Antagonists; Animals; Bronchodilator Agents; Cyclic AMP; Cyclic GMP; Drug Synergism; Epinephrine; Guinea Pigs; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Prostaglandins E; Quinazolines; Trachea | 1980 |
Plasma renin activity and plasma concentrations of norepinephrine and cyclic nucleotides in heart failure after prazosin.
Topics: Adult; Aged; Cyclic AMP; Cyclic GMP; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Norepinephrine; Prazosin; Quinazolines; Renin | 1981 |
A selective type V phosphodiesterase inhibitor, E4021, dilates porcine large coronary artery.
Topics: Animals; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Isoenzymes; Isosorbide Dinitrate; Male; Phosphodiesterase Inhibitors; Piperidines; Quinazolines; Rabbits; Swine; Vasodilation | 1995 |
Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Calmodulin; Chromatography, DEAE-Cellulose; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Hydrolysis; In Vitro Techniques; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Papaverine; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Quinazolines; Rolipram; Ureter | 1994 |
Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Coronary Vessels; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Muscle, Smooth, Vascular; Quinazolines; Spectrometry, Fluorescence; Structure-Activity Relationship; Swine; Vasodilation | 1994 |
Cyclic GMP phosphodiesterase inhibitors. 1. The discovery of a novel potent inhibitor, 4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Chromones; Coronary Vessels; Cyclic GMP; Dinoprost; Isoenzymes; Molecular Structure; Muscle Relaxation; Purinones; Quinazolines; Structure-Activity Relationship; Swine | 1993 |
Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium Channel Blockers; Cyclic GMP; Diltiazem; Hemodynamics; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; Nitric Oxide; Perfusion; Phosphodiesterase Inhibitors; Piperidines; Pulmonary Circulation; Purinones; Quinazolines; Rats; Rats, Sprague-Dawley; Vasodilation | 1996 |
Phosphodiesterase isoenzymes in human ureteral smooth muscle: identification, characterization, and functional effects of various phosphodiesterase inhibitors in vitro.
Topics: Chromatography, Ion Exchange; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Hydrolysis; In Vitro Techniques; Isoenzymes; Muscle Contraction; Muscle, Smooth; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrrolidinones; Quinazolines; Rolipram; Ureter | 1995 |
Differential modulation of cytokine production by drugs: implications for therapy in heart failure.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Amrinone; Cells, Cultured; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Heart Failure; Humans; Interleukin-1; Interleukin-6; Kinetics; Leukocytes, Mononuclear; Lipopolysaccharides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Pyrazines; Pyridazines; Quinazolines; Quinolines; Tumor Necrosis Factor-alpha | 1996 |
Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa.
Topics: Alkaloids; Blood Platelets; Cyclic AMP; Cyclic GMP; Humans; Indole Alkaloids; Nitric Oxide; Phosphatidylinositols; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinazolines; Thromboxane B2 | 1996 |
Cyclic nucleotide phosphodiesterase in human cavernous smooth muscle.
Topics: Animals; Cyclic AMP; Cyclic GMP; Humans; In Vitro Techniques; Isoenzymes; Male; Muscle, Smooth; Papaverine; Penile Erection; Penis; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrrolidinones; Quinazolines; Rolipram | 1997 |
Potency and mechanism of action of E4021, a type 5 phosphodiesterase isozyme-selective inhibitor, on the photoreceptor phosphodiesterase depend on the state of activation of the enzyme.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Binding, Competitive; Catalytic Domain; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclic Nucleotide Phosphodiesterases, Type 6; Enzyme Activation; Holoenzymes; Isoenzymes; Phosphodiesterase Inhibitors; Photoreceptor Cells, Vertebrate; Piperidines; Quinazolines; Ranidae | 1999 |
E4021, a selective phosphodiesterase 5 inhibitor, potentiates the vasodilator effect of inhaled nitric oxide in isolated perfused rat lungs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Inhalation; Animals; Bronchodilator Agents; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Synergism; Hypertension, Pulmonary; In Vitro Techniques; Isoproterenol; Lung; Male; Nitric Oxide; Nitroprusside; Perfusion; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Pulmonary Circulation; Quinazolines; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 1999 |
Vasorelaxing action of rutaecarpine: effects of rutaecarpine on calcium channel activities in vascular endothelial and smooth muscle cells.
Topics: 4-Aminopyridine; Alkaloids; Animals; Aorta, Thoracic; Calcium; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Hydroquinones; In Vitro Techniques; Indole Alkaloids; Isometric Contraction; Male; Membrane Potentials; Models, Cardiovascular; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Patch-Clamp Techniques; Potassium Channel Blockers; Quinazolines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1999 |
The cGMP-specific phosphodiesterase inhibitor E4021 dilates the pulmonary circulation.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fetus; Humans; Infant, Newborn; Infusions, Intravenous; Nitric Oxide; Persistent Fetal Circulation Syndrome; Phosphodiesterase Inhibitors; Piperidines; Pregnancy; Pulmonary Artery; Pulmonary Circulation; Quinazolines; Sheep; Statistics, Nonparametric; Vasodilation | 1999 |
Relaxation of human ureteral smooth muscle in vitro by modulation of cyclic nucleotide-dependent pathways.
Topics: Colforsin; Cyclic AMP; Cyclic GMP; Humans; In Vitro Techniques; Isoquinolines; Muscle, Smooth; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Platelet Aggregation Inhibitors; Potassium Chloride; Purinones; Quinazolines; Rolipram; Tetrahydroisoquinolines; Ureter; Vasodilator Agents | 2000 |
Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Antineoplastic Agents; Apoptosis; beta Catenin; Cadherins; Colonic Neoplasms; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoskeletal Proteins; Enzyme Activation; Humans; Isoenzymes; Kinetics; Phosphodiesterase Inhibitors; Piperidines; Protein Kinases; Quinazolines; Sulindac; Trans-Activators; Tumor Cells, Cultured | 2000 |
Nitric oxide-induced cGMP accumulation in the mouse bladder is not related to smooth muscle relaxation.
Topics: Animals; Arginine; Carbachol; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Mice; Mice, Inbred BALB C; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Phosphodiesterase Inhibitors; Piperazines; Piperidines; Purines; Quinazolines; Sildenafil Citrate; Sulfones; Urethra; Urinary Bladder | 2000 |
Functional identification of phosphodiesterase activity in human trabecular meshwork cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Cells, Cultured; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Humans; Isoproterenol; Nitroprusside; Piperidines; Quinazolines; Signal Transduction; Trabecular Meshwork | 2000 |
Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors.
Topics: Animals; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Heart Rate; Hydrazines; Indoles; Isoquinolines; Male; Milrinone; Models, Biological; Molsidomine; Nitric Oxide Donors; Nitrogen Oxides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Pyrroles; Quinazolines; Ryanodine; Sarcoplasmic Reticulum; Signal Transduction; Spectrometry, Fluorescence; Sulfonamides; Superoxide Dismutase; Tetrahydroisoquinolines; Thionucleotides; Time Factors; Vasodilator Agents | 2000 |
KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dogs; Dose-Response Relationship, Drug; Imidazoles; Isoenzymes; Kinetics; Molecular Structure; Nitroglycerin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Platelet Aggregation Inhibitors; Purines; Quinazolines; Rabbits; Sildenafil Citrate; Sulfones | 2001 |
Effects of intracavernous administration of adrenomedullin on erectile function in rats.
Topics: Adrenomedullin; Animals; Arginine; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Erectile Dysfunction; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penile Erection; Peptides; Phosphodiesterase Inhibitors; Piperidines; Quinazolines; Rats; Rats, Wistar | 2001 |
Inhibition of ovarian steroidogenesis by cyclic GMP in a fly.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Alkaloids; Animals; Brain; Calcium Channels; Carbazoles; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diptera; Ecdysteroids; Female; Indoles; Organ Culture Techniques; Ovary; Phosphodiesterase Inhibitors; Quinazolines; Signal Transduction; Stimulation, Chemical | 2003 |
Lack of cyclic nucleotide regulation of MBCQ-induced relaxation of rat ileal smooth muscle.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbachol; Cholinergic Agonists; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dipyridamole; Ileum; Male; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Potassium; Purinones; Quinazolines; Rats; Rats, Wistar | 2003 |
Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors.
Topics: Animals; Corpus Striatum; Crystallography, X-Ray; Cyclic GMP; Mice; Models, Molecular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidines; Quinazolines; Structure-Activity Relationship | 2007 |
Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH.
Topics: Amphiregulin; Animals; Cyclic GMP; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Gap Junctions; Glycoproteins; Immunoblotting; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Meiosis; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Ovarian Follicle; Quinazolines; Tyrphostins | 2010 |
Epidermal growth factor-network signaling mediates luteinizing hormone regulation of BNP and CNP and their receptor NPR2 during porcine oocyte meiotic resumption.
Topics: Amphiregulin; Animals; Cyclic GMP; DNA Primers; Female; Granulosa Cells; In Situ Hybridization; Luteinizing Hormone; Meiosis; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Oocytes; Quinazolines; Radioimmunoassay; Real-Time Polymerase Chain Reaction; Receptors, Atrial Natriuretic Factor; Signal Transduction; Swine; Tyrphostins | 2014 |
Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.
Topics: 2,4-Dichlorophenoxyacetic Acid; Acridines; Adenosine Triphosphate; Animals; Biological Transport; Blood-Brain Barrier; Brain; Central Nervous System; Cyclic GMP; Humans; Kinetics; Male; Methotrexate; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Ochratoxins; Pravastatin; Quinazolines; Quinolines; Tetrahydroisoquinolines; Thiophenes; Uric Acid | 2017 |
Rutaecarpine Inhibits Intimal Hyperplasia in A Balloon-Injured Rat Artery Model.
Topics: Actins; Animals; Carotid Arteries; Carotid Artery Injuries; Cyclic GMP; Disease Models, Animal; Gene Expression Regulation; Hyperplasia; Indole Alkaloids; Male; Nitric Oxide; Phosphorylation; Proliferating Cell Nuclear Antigen; Quinazolines; Rats, Sprague-Dawley; RNA, Messenger; Tunica Intima | 2018 |
Quinazoline-based human phosphodiesterase 5 inhibitors exhibited a selective vasorelaxant effect on rat isolated pulmonary arteries involving NO-sGC-cGMP pathway and calcium inhibitory effects.
Topics: Animals; Calcium; Cyclic GMP; Humans; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Quinazolines; Rats; Sildenafil Citrate; Vasodilation; Vasodilator Agents | 2022 |