Compounds > quinazolines
Page last updated: 2024-08-21

quinazolines and cyclazosin

quinazolines has been researched along with cyclazosin in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (27.78)18.2507
2000's9 (50.00)29.6817
2010's2 (11.11)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Giardinà, D; Gulini, U; Massi, M; Melchiorre, C; Piloni, MG; Pompei, P; Rafaiani, G1
Crucianelli, M; Giardinà, D; Melchiorre, C; Taddei, C; Testa, R1
Crucianelli, M; Giardinà, D; Leonardi, A; Melchiorre, C; Poggesi, E; Romanelli, R1
Saxena, PR; Stam, WB; Van der Graaf, PH1
Budriesi, R; Chiarini, A; Leonardi, A; Melchiorre, C; Minarini, A1
De Groat, WC; Yoshiyama, M1
Angeli, P; Giardinà, D; Gulini, U; Leonardi, A; Marucci, G; Melchiorre, C; Poggesi, E; Polimanti, O; Sagratini, G1
Cerri, PS; de Arruda Camargo, GM; de Arruda Camargo, LA; Saad, WA1
Avellar, MC; Hamamura, M; Mendes, FR; Porto, CS; Queiróz, DB1
Antolini, L; Giardinà, D; Grelli, M; Gulini, U; Melchiorre, C; Sagratini, G1
Angeli, P; Buccioni, M; Giardinà, D; Gulini, U; Marucci, G; Melchiorre, C; Sagratini, G; Testa, R1
Angeli, P; Buccioni, M; Giardinà, D; Gulini, U; Leonardi, A; Marucci, G; Melchiorre, C; Poggesi, E; Sagratini, G1
Bexis, S; Docherty, JR1
Imanishi, A; Latifpour, J; Ueda, S; Yamamoto, Y; Yono, M; Yoshida, M1
Aono, Y; Cools, AR; Koshikawa, N; Saigusa, T; Shimizu, N; Shirakawa, T; Taguchi, H; Takada, K; Takiguchi, H; Uchida, T1
Abdelkarim, H; Albee, LJ; Gao, X; Gaponenko, V; Majetschak, M; Volkman, BF1
Alsufyani, HA; Docherty, JR; McCormick, PA1
Chalmers, DK; Cridge, RR; de Zhang, LA; Deluigi, M; Eberle, SA; Egloff, P; Klenk, C; Klipp, A; Merklinger, L; Mittl, PRE; Morstein, L; Plückthun, A; Schuster, M; Scott, DJ; Vacca, S; Vaid, TM; Zerbe, O1

Other Studies

18 other study(ies) available for quinazolines and cyclazosin

ArticleYear
Structure-activity relationships in prazosin-related compounds. 2. Role of the piperazine ring on alpha-blocking activity.
    Journal of medicinal chemistry, 1993, Mar-19, Volume: 36, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Hemodynamics; Male; Piperazines; Prazosin; Quinazolines; Quinoxalines; Rats; Rats, Inbred SHR; Stereoisomerism; Structure-Activity Relationship

1993
Receptor binding profile of cyclazosin, a new alpha 1B-adrenoceptor antagonist.
    European journal of pharmacology, 1995, Dec-04, Volume: 287, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Brain; Male; Prazosin; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1

1995
Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.
    Journal of medicinal chemistry, 1996, Nov-08, Volume: 39, Issue:23

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Cattle; Cerebral Cortex; CHO Cells; COS Cells; Cricetinae; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Stereoisomerism

1996
Functional characterisation of the pharmacological profile of the putative alpha1B-adrenoceptor antagonist, (+)-cyclazosin.
    European journal of pharmacology, 1998, Nov-13, Volume: 361, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Dose-Response Relationship, Drug; In Vitro Techniques; Isometric Contraction; Male; Mesenteric Arteries; Mice; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Spleen; Vasoconstrictor Agents

1998
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.
    Bioorganic & medicinal chemistry letters, 1998, Jun-02, Volume: 8, Issue:11

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Drug Design; Humans; In Vitro Techniques; Male; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Spleen; Structure-Activity Relationship; Vas Deferens

1998
Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:5

    Topics: Anesthesia, General; Animals; Brain Stem; Efferent Pathways; Female; Injections, Spinal; Locus Coeruleus; Models, Neurological; Muscle Contraction; Piperazines; Pressure; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Reflex; Thymine; Urethane; Urinary Bladder

2001
Searching for cyclazosin analogues as alpha(1B)-adrenoceptor antagonists.
    Farmaco (Societa chimica italiana : 1989), 2003, Volume: 58, Issue:7

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Binding Sites; CHO Cells; Clone Cells; Cricetinae; Guinea Pigs; Humans; Male; Prazosin; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1; Spleen; Vas Deferens

2003
Effects of subtypes of adrenergic and angiotensinergic antagonists on the water and sodium intake induced by adrenaline injected into the paraventricular nucleus.
    Brain research, 2003, Dec-24, Volume: 994, Issue:2

    Topics: Adrenergic alpha-Antagonists; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Diuretics; Dose-Response Relationship, Drug; Drinking; Epinephrine; Feeding Behavior; Furosemide; Losartan; Male; Oligopeptides; Paraventricular Hypothalamic Nucleus; Piperazines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary

2003
Effects of androgen manipulation on alpha1-adrenoceptor subtypes in the rat seminal vesicle.
    Life sciences, 2004, Aug-06, Volume: 75, Issue:12

    Topics: Adrenergic alpha-1 Receptor Antagonists; Analysis of Variance; Androgens; Animals; Autoradiography; Barium Compounds; Chlorides; Clonidine; Cyproterone Acetate; Dioxanes; Gene Expression Regulation; Male; Orchiectomy; Organ Size; Phenylephrine; Piperazines; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; RNA, Messenger; Seminal Vesicles; Testosterone

2004
Absolute configuration of the alpha (1B)-adrenoceptor antagonist (+)-cyclazosin.
    Farmaco (Societa chimica italiana : 1989), 2004, Volume: 59, Issue:12

    Topics: Adrenergic alpha-1 Receptor Antagonists; Crystallography, X-Ray; Hydrogen Bonding; Molecular Conformation; Quinazolines; Quinoxalines; Stereoisomerism

2004
(+)-Cyclazosin, a selective alpha1B-adrenoceptor antagonist: functional evaluation in rat and rabbit tissues.
    European journal of pharmacology, 2005, Oct-17, Volume: 522, Issue:1-3

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Methoxamine; Molecular Structure; Muscle Contraction; Norepinephrine; Quinazolines; Quinoxalines; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Vas Deferens; Vasoconstriction

2005
Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin.
    Bioorganic & medicinal chemistry, 2007, Mar-15, Volume: 15, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta; Binding, Competitive; Furans; Male; Molecular Structure; Prazosin; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Stereoisomerism; Structure-Activity Relationship; Vas Deferens

2007
Role of alpha1-adrenoceptor subtypes in the effects of methylenedioxy methamphetamine (MDMA) on body temperature in the mouse.
    British journal of pharmacology, 2008, Volume: 153, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Body Temperature; Fever; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Prazosin; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha-1; Thymine

2008
Differential effects of prazosin and naftopidil on pelvic blood flow and nitric oxide synthase levels in spontaneously hypertensive rats.
    Journal of receptor and signal transduction research, 2008, Volume: 28, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Hypertension; Male; Naphthalenes; Nitric Oxide Synthase; Pelvis; Penis; Piperazines; Prazosin; Prostate; Quinazolines; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Regional Blood Flow; Urinary Bladder

2008
Simultaneous activation of the α1A-, α1B- and α1D-adrenoceptor subtypes in the nucleus accumbens reduces accumbal dopamine efflux in freely moving rats.
    Behavioural pharmacology, 2015, Volume: 26, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-1 Receptor Agonists; Animals; Dopamine; Dose-Response Relationship, Drug; Male; Methoxamine; Microdialysis; Nucleus Accumbens; Piperazines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1

2015
Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3.
    PloS one, 2018, Volume: 13, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; beta-Arrestins; Binding Sites; Cells, Cultured; Chemokine CXCL12; Chemotaxis; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Humans; MAP Kinase Signaling System; Myocytes, Smooth Muscle; Nuclear Magnetic Resonance, Biomolecular; Prazosin; Quinazolines; Quinoxalines; Receptors, CXCR; Receptors, CXCR4

2018
Both α
    Pharmacological reports : PR, 2021, Volume: 73, Issue:1

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Male; Muscle Contraction; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Thymine; Yohimbine

2021
Crystal structure of the α
    Nature communications, 2022, 01-19, Volume: 13, Issue:1

    Topics: Binding Sites; Crystallography, X-Ray; HEK293 Cells; Humans; Ligands; Lipids; Models, Molecular; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2

2022