quinazolines has been researched along with cr4056 in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 4 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Caselli, G; Ferrari, F; Lanza, M; Menghetti, I; Tremolada, D | 1 |
| He, XH; Li, JX; Qiu, Y; Zhang, Y | 1 |
| Jia, S; Li, JX; Qiu, Y; Thorn, DA; Zhang, Y | 1 |
| Li, JX; Siemian, JN; Wang, K; Zhang, Y | 1 |
| Li, JX; Seaman, RW; Shang, L; Siemian, JN; Zhang, Y; Zhu, Q | 1 |
| Caselli, G; Giacomoni, C; Lanza, M; Letari, O; Milia, C; Rovati, LC; Sabatini, C; Vellani, V | 1 |
| Blicharski, T; Bonazzi, A; Brambilla, N; Connell, J; D'Amato, M; Giacovelli, G; Girolami, F; Rovati, LC; Vitalini, C | 1 |
| Bonazzi, A; Borsi Franchini, M; Caselli, G; Comi, E; Ferrari, F; Lanza, M; Milia, C; Rovati, LC; Sabatini, C; Sala, E | 1 |
| Abelleira-Hervas, L; Aleksynas, R; Ashburner, N; Caselli, G; Liu, L; Mota, BC; Rovati, LC; Sastre, M | 1 |
1 trial(s) available for quinazolines and cr4056
| Article | Year |
|---|---|
Efficacy and safety of the first-in-class imidazoline-2 receptor ligand CR4056 in pain from knee osteoarthritis and disease phenotypes: a randomized, double-blind, placebo-controlled phase 2 trial.
Topics: Arthralgia; Double-Blind Method; Female; Humans; Imidazoles; Male; Middle Aged; Osteoarthritis, Knee; Pain Measurement; Proof of Concept Study; Quinazolines; Treatment Outcome | 2020 |
8 other study(ies) available for quinazolines and cr4056
| Article | Year |
|---|---|
Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Binding Sites; Drug Synergism; Female; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Morphine; Naloxone; Narcotic Antagonists; Pain, Postoperative; Quinazolines; Rats, Sprague-Dawley; Yohimbine | 2014 |
Discriminative stimulus effects of the novel imidazoline I₂ receptor ligand CR4056 in rats.
Topics: Animals; Benzofurans; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Methadone; Morphine; Quinazolines; Rats | 2014 |
Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzofurans; Disease Models, Animal; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Injections, Intraventricular; Locomotion; Male; Pain; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Time Factors | 2016 |
Mechanisms of imidazoline I
Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Biogenic Monoamines; Discrimination, Psychological; Drug Interactions; Hypothermia, Induced; Imidazoles; Imidazoline Receptors; Male; Neurotransmitter Uptake Inhibitors; Pain Measurement; Quinazolines; Rats; Serotonin Antagonists; Synaptic Transmission | 2018 |
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Pain; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Reserpine | 2019 |
CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKCε phosphorylation and membrane translocation in sensory neurons.
Topics: Amino Acid Sequence; Analgesics; Animals; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Freund's Adjuvant; Humans; Imidazoles; Imidazoline Receptors; Inflammation; Male; Pain; Phosphorylation; Protein Kinase C-epsilon; Quinazolines; Rats; Rats, Wistar; Sensory Receptor Cells | 2020 |
Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Imidazoles; Morphine; Quinazolines; Rats; Rodentia | 2020 |
I2-Imidazoline Ligand CR4056 Improves Memory, Increases ApoE Expression and Reduces BBB Leakage in 5xFAD Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; Blood-Brain Barrier; Disease Models, Animal; Imidazoles; Imidazolines; Ligands; Mice; Mice, Transgenic; Quinazolines | 2022 |