quinazolines has been researched along with ast 1306 in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y; Chen, Z; Ding, J; Geng, M; Jiang, H; Jiang, X; Jiang, Y; Lin, L; Qu, W; Ren, X; Tong, L; Wan, H; Xie, H; Yang, Y; Zhang, X; Zheng, M; Zuo, J | 1 |
| Chen, X; Gao, Z; Lin, L; Zhong, D | 1 |
| Chen, X; Gao, Z; Lin, L; Xie, C; Zhong, D | 1 |
| Cao, J; Chen, Z; Li, J; Peng, W; Sun, S; Wang, J; Zhang, J; Zhang, X; Zhang, Y; Zhao, N; Zhong, D | 1 |
| Chen, ZS; Fu, LW; Kathawala, RJ; Patel, A; Talele, TT; Wang, DS; Wang, YJ; Zhang, H; Zhang, YK | 1 |
| Carvalho, AL; Cruvinel-Carloni, A; de Paula, FE; de Souza Viana, L; Martinho, O; Melendez, ME; Reis, RM; Rosa, MN; Silva, VA; Silva-Oliveira, RJ | 1 |
| Baltazar, F; Barbosa, AM; Cardoso-Carneiro, D; Cury, FP; de Paula, FE; Evangelista, AF; Granja, S; Longatto-Filho, A; Marques, F; Martinho, O; Miranda-Gonçalves, V; Moreira, MA; Reis, RM; Scapulatempo-Neto, C; Silva-Oliveira, R; Zanon, M | 1 |
| Gong, L; Liu, J; Qian, Z; Song, G; Xu, J | 1 |
| Chen, XY; Jiang, JF; Zhong, DF | 1 |
1 review(s) available for quinazolines and ast 1306
| Article | Year |
|---|---|
[Metabolic research of domestically developed small molecule tyrosine kinase inhibitors].
Topics: Acrylamides; Aniline Compounds; Antineoplastic Agents; Benzofurans; China; Crown Ethers; Drug Interactions; Humans; Indoles; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Quinazolines | 2016 |
2 trial(s) available for quinazolines and ast 1306
| Article | Year |
|---|---|
Metabolism and pharmacokinetics of allitinib in cancer patients: the roles of cytochrome P450s and epoxide hydrolase in its biotransformation.
Topics: Acrylamides; Antineoplastic Agents; Biotransformation; Caco-2 Cells; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Feces; Female; Humans; Male; Mass Spectrometry; Microsomes, Liver; Neoplasms; Permeability; Quinazolines | 2014 |
A phase I study of AST1306, a novel irreversible EGFR and HER2 kinase inhibitor, in patients with advanced solid tumors.
Topics: Acrylamides; Adolescent; Adult; Aged; Dose-Response Relationship, Drug; ErbB Receptors; Female; Humans; Male; Middle Aged; Neoplasms; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Treatment Outcome; Young Adult | 2014 |
6 other study(ies) available for quinazolines and ast 1306
| Article | Year |
|---|---|
AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo.
Topics: Acrylamides; Amino Acids; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Gene Silencing; Humans; Mice; Mice, Transgenic; Mutant Proteins; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Signal Transduction; Xenograft Model Antitumor Assays | 2011 |
Development and validation of a sensitive LC-MS/MS assay for the simultaneous quantification of allitinib and its two metabolites in human plasma.
Topics: Acrylamides; Chromatography, Liquid; Humans; Mass Spectrometry; Quinazolines; Tandem Mass Spectrometry | 2013 |
AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.
Topics: Acrylamides; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Mitoxantrone; Molecular Docking Simulation; Neoplasm Proteins; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2 | 2014 |
Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker.
Topics: Acrylamides; Cell Line, Tumor; Cell Survival; DNA Mutational Analysis; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Mutation; Neoplasms; Proto-Oncogene Proteins p21(ras); Quinazolines | 2016 |
HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors.
Topics: Acrylamides; Adenocarcinoma; Antimetabolites; Antineoplastic Agents; Biomarkers, Tumor; Diagnostic Tests, Routine; Drug Resistance, Neoplasm; ErbB Receptors; Female; Glucose; Humans; Lapatinib; Quinazolines; Theranostic Nanomedicine; Therapeutic Uses; Uterine Cervical Neoplasms | 2017 |
ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway.
Topics: Acrylamides; Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Transplantation; Phosphatidylinositol 3-Kinases; Prognosis; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-4; Signal Transduction; Stomach Neoplasms; Survival Analysis; Up-Regulation | 2018 |