quinazolines has been researched along with ag 1879 in 36 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 27 (75.00) | 29.6817 |
2010's | 9 (25.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Berk, BC; Chen, K; Keaney, JF; Vita, JA | 1 |
Barrett, KE; McCole, DF; Uribe, JM | 1 |
Li, J; Majumdar, AP; Xiao, ZQ | 1 |
Arbel, R; Ben-Bassat, H; Hartzstark, Z; Klein, BY; Laufer, N; Levitzki, R; Rojansky, N | 1 |
Bader, B; Glienke, J; Sturz, A; Thierauch, KH | 1 |
Slomiany, A; Slomiany, BL | 2 |
Anaganti, S; Billaud, M; Carlomagno, F; Fusco, A; Guida, T; Ryan, AJ; Santoro, M; Vecchio, G | 1 |
Baumgarten, CM; Ren, Z | 1 |
Delamere, NA; Tamiya, S | 1 |
Bigner, DD; Kwatra, MM; Richardson, MD; Yamaguchi, K | 1 |
Churg, A; Vincent, R; Wang, RD; Wang, X; Xie, C | 1 |
Ali, N; Fujita, Y; Ishizawa, K; Izawa, Y; Kanematsu, Y; Ohnishi, H; Tamaki, T; Tsuchiya, K; Yoshizumi, M | 1 |
Kim, SY; Kim, YK; Kwon, CH; Lee, JS | 1 |
Cai, K; Enomoto, A; Hosoi, Y; Li, Z; Matsumoto, Y; Miyagawa, K; Morita, A; Nakagawa, K; Tanno, Y | 1 |
Alagarsamy, S; Alexander, LD; Cui, XL; Ding, Y; Douglas, JG | 1 |
Boron, WF; Bouyer, P; Zhou, Y | 1 |
Azar, ZM; Mehdi, MZ; Srivastava, AK | 1 |
Ascoli, M; Shiraishi, K | 1 |
Abel, J; Cline, JE; Fritsche, E; Moors, M | 1 |
Botta, M; Manetti, F; Schenone, S | 1 |
Chen, YR; Cheng, HH; Fu, YN; Huang, SF; Tsai, SF; Yang, CH; Yeh, CL | 1 |
Bhattacharya, S; Johnson, LR; Ray, RM | 1 |
Cruz-Rangel, S; Islas, LD; Lezama, RA; Pasantes-Morales, H; Ramos-Mandujano, G; Vázquez-Juárez, E | 1 |
Cheon, H; Cho, S; Kim, HJ; Kim, HS; Lee, JY; Sohn, J; Won, NH; Woo, YS | 1 |
Linsdell, P; McDonald, TF; Missan, S | 1 |
Choi, WS; Han, JW; Jeong, KJ; Kang, JK; Kim, YK; Lee, HY; Lee, KB; Park, CG; Park, SY; Seo, JH | 1 |
Bareford, MD; Cruickshanks, N; Dai, Y; Dent, P; Grant, S; Hamed, HA; Hubbard, N; Mitchell, C; Tang, Y; Tye, G; Yacoub, A | 1 |
Blanco, G; Jansson, K; Nguyen, AN; Reif, GA; Sánchez, G; Sharma, M; Wallace, DP | 1 |
Adès, L; Boehrer, S; Bouteloup, C; de Botton, S; Fenaux, P; Galluzzi, L; Gardin, C; Harper, F; Kroemer, G; Lainey, E; Pierron, G; Sébert, M; Tailler, M; Thépot, S | 1 |
Cicha, I; Daniel, WG; Garlichs, CD; Urschel, K | 1 |
Chen, SY; Hsu, HC; Huang, CY; Tang, CH; Tsai, HC | 1 |
Jeong, YJ; Kim, CH; Kim, DJ; Kim, JC; Lee, KB; Oh, SM; Park, JH | 1 |
Liu, Y; Wang, Y; Wu, W; Xu, Y; Zhang, H | 1 |
Jensen, RT; Moody, TW; Moreno, P; Nuche-Berenguer, B | 1 |
Ciotkowska, A; Gratzke, C; Hennenberg, M; Herlemann, A; Janich, S; Liu, C; Rutz, B; Stief, CG; Strittmatter, F; Tamalunas, A; Waidelich, R; Wang, Y | 1 |
1 review(s) available for quinazolines and ag 1879
Article | Year |
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SRC inhibitors and angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Humans; Neoplasms; Neovascularization, Physiologic; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Quinazolines; src-Family Kinases; Structure-Activity Relationship | 2007 |
35 other study(ies) available for quinazolines and ag 1879
Article | Year |
---|---|
c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aorta; Benzoquinones; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Genistein; GRB2 Adaptor Protein; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Pyrimidines; Quinazolines; Quinones; Rifabutin; Swine; Transcriptional Activation; Tyrphostins | 2001 |
Interferon-gamma activates EGF receptor and increases TGF-alpha in T84 cells: implications for chloride secretion.
Topics: Antibodies; Blotting, Western; Carbachol; Cell Line; Cell Membrane; Chlorides; Colon; Enzyme Inhibitors; ErbB Receptors; Humans; Immunosorbent Techniques; Interferon-gamma; Intestinal Mucosa; Kinetics; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; src-Family Kinases; Transforming Growth Factor alpha; Tyrphostins | 2002 |
Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.
Topics: Aging; Animals; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Gastric Mucosa; Male; Mitogen-Activated Protein Kinase Kinases; Pyrimidines; Quinazolines; Rats; Rats, Inbred F344; Signal Transduction; src-Family Kinases; Transcription Factor AP-1; Transforming Growth Factor alpha | 2003 |
Inhibitors that target protein kinases for the treatment of ovarian carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Catechols; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Nitriles; Ovarian Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Time Factors; Tumor Cells, Cultured; Tyrphostins | 2003 |
EphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration.
Topics: Animals; Cell Movement; Cells, Cultured; CHO Cells; Cricetinae; Endothelium, Vascular; Enzyme Inhibitors; Ephrin-B2; ErbB Receptors; Humans; Microcirculation; Phosphorylation; Pyrimidines; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, EphB4; Recombinant Proteins; Signal Transduction; src-Family Kinases; Vascular Endothelial Growth Factors | 2004 |
Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Androstadienes; Animals; Bucladesine; Choline; Colforsin; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Isoproterenol; Phosphoinositide-3 Kinase Inhibitors; Phospholipids; Pyrimidines; Quinazolines; Rats; Receptors, Adrenergic, beta; Saliva; src-Family Kinases; Sublingual Gland; Transcriptional Activation; Wortmannin | 2004 |
Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors.
Topics: Carcinoma, Medullary; Catalytic Domain; Cell Line; Drug Resistance; Enzyme Inhibitors; Mitogens; Piperidines; Point Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Pyrazoles; Pyrimidines; Quinazolines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thyroid Neoplasms; Valine | 2004 |
Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases.
Topics: Animals; Cadmium; Chloride Channels; Enzyme Inhibitors; ErbB Receptors; Genistein; Heart Ventricles; Membrane Potentials; Pyrimidines; Quinazolines; Rabbits; src-Family Kinases; Tamoxifen; Ventricular Function | 2005 |
Porphyromonas gingivalis lipopolysaccharide-induced up-regulation in endothelin-1 interferes with salivary mucin synthesis via epidermal growth factor receptor transactivation.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; ErbB Receptors; Lipopolysaccharides; Mucins; Oligopeptides; Porphyromonas gingivalis; Pyrimidines; Quinazolines; Rats; Saliva; Salivary Glands; src-Family Kinases; Time Factors; Transcriptional Activation; Trypan Blue; Up-Regulation | 2004 |
Studies of tyrosine phosphorylation and Src family tyrosine kinases in the lens epithelium.
Topics: Animals; Blotting, Western; Cell Proliferation; Enzyme Inhibitors; Epithelium; Lens, Crystalline; Organ Culture Techniques; Phosphorylation; Phosphotyrosine; Proliferating Cell Nuclear Antigen; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; src-Family Kinases; Swine; Tyrosine; Tyrphostins | 2005 |
Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
Topics: Acetophenones; Benzopyrans; Cell Line, Tumor; Cell Proliferation; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; Intracellular Signaling Peptides and Proteins; Oligonucleotides, Antisense; Phosphorylation; Protein Kinase C-delta; Pyrimidines; Quinazolines; Receptors, Neurokinin-1; RNA, Small Interfering; Signal Transduction; Tyrphostins | 2005 |
Air pollution particles activate NF-kappaB on contact with airway epithelial cell surfaces.
Topics: Air Pollutants; Animals; Binding, Competitive; Biological Transport; Deferoxamine; Dust; Epithelial Cells; Ferric Compounds; Free Radical Scavengers; In Vitro Techniques; NF-kappa B; Particle Size; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiourea; Time Factors; Titanium; Trachea; Tyrphostins | 2005 |
Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation.
Topics: Atherosclerosis; Benzoquinones; Blotting, Western; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Cinnamates; CSK Tyrosine-Protein Kinase; Disease Progression; Endothelial Cells; Endothelium, Vascular; Humans; Immunoblotting; Immunoprecipitation; Lactams, Macrocyclic; Ligands; Lysophosphatidylcholines; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Quinones; Rifabutin; src-Family Kinases; Transcriptional Activation; Transfection; Vascular Endothelial Growth Factor Receptor-2 | 2006 |
EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells.
Topics: Animals; Apoptosis; Butadienes; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hydrogen Peroxide; Kidney Tubules, Proximal; MAP Kinase Kinase 1; Membrane Potentials; Mitochondrial Membranes; Nitriles; Opossums; Oxidants; Pyrimidines; Quinazolines; Transfection; Tyrphostins | 2006 |
Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.
Topics: Androstadienes; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Infrared Rays; Intracellular Signaling Peptides and Proteins; Kinetics; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; Radiation, Ionizing; Signal Transduction; src-Family Kinases; Temperature; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Wortmannin; X-Rays | 2006 |
Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor.
Topics: Angiotensin II; Animals; Arachidonic Acid; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Glutathione Transferase; Kidney Tubules, Proximal; Kinetics; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Quinazolines; Rabbits; Recombinant Fusion Proteins; Transcriptional Activation; Tyrphostins | 2006 |
Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules.
Topics: Absorption; Animals; Bicarbonates; Carbon Dioxide; Dimethyl Sulfoxide; Enzyme Inhibitors; Female; Genistein; Imidazoles; Kidney Tubules, Proximal; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Rabbits; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction | 2006 |
Activation of insulin-like growth factor type-1 receptor is required for H2O2-induced PKB phosphorylation in vascular smooth muscle cells.
Topics: Animals; Cell Line; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Focal Adhesion Kinase 2; Hydrogen Peroxide; Immunoblotting; Insulin-Like Growth Factor I; Models, Biological; Muscle, Smooth, Vascular; Oxidants; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Receptor, IGF Type 1; src-Family Kinases; Tyrosine; Tyrphostins | 2006 |
Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.
Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Dipeptides; Epidermal Growth Factor; Flavonoids; Immunohistochemistry; Inositol Phosphates; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyrazoles; Pyrimidines; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Steroids; Tyrphostins | 2007 |
ERK-dependent and -independent pathways trigger human neural progenitor cell migration.
Topics: Astrocytes; Blotting, Western; Cell Differentiation; Cell Movement; Cell Survival; Cells, Cultured; Flavonoids; Humans; Indoles; Maleimides; Methylmercury Compounds; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Protein Kinase C; Pyrimidines; Quinazolines; Signal Transduction; Spheroids, Cellular; src-Family Kinases; Stem Cells; Sulfonamides; Tetradecanoylphorbol Acetate; Tyrphostins | 2007 |
EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy.
Topics: Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Exons; Gefitinib; Humans; Immunoprecipitation; Lung Neoplasms; Phosphorylation; Point Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Quinazolines; Sequence Deletion; Tyrosine | 2008 |
EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.
Topics: Animals; Apoptosis; Cell Survival; Cycloheximide; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibronectins; Integrin beta3; Intestinal Mucosa; MAP Kinase Kinase Kinases; Mice; Mutation; Oligopeptides; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphorylation; Polyamines; Protein Kinase Inhibitors; Putrescine; Pyrimidines; Quinazolines; Rats; Signal Transduction; src-Family Kinases; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2007 |
Thrombin increases hyposmotic taurine efflux and accelerates ICI-swell and RVD in 3T3 fibroblasts by a src-dependent EGFR transactivation.
Topics: Animals; Calcium; Cell Size; Chloride Channels; Chlorides; Egtazic Acid; Enzyme Inhibitors; ErbB Receptors; Estrenes; Hemostatics; Mice; Osmotic Pressure; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pyrimidines; Pyrrolidinones; Quinazolines; Signal Transduction; src-Family Kinases; Swiss 3T3 Cells; Taurine; Thrombin; Tritium; Tyrphostins | 2008 |
Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages.
Topics: Animals; Benzoflavones; Cell Differentiation; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Genistein; Hazardous Substances; Humans; Macrophages; MAP Kinase Signaling System; Mice; Phosphorylation; Polychlorinated Dibenzodioxins; Pyrimidines; Quinazolines; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; src-Family Kinases; Tumor Necrosis Factor-alpha | 2007 |
Involvement of tyrosine kinase in the hyposmotic stimulation of I Ks in guinea-pig ventricular myocytes.
Topics: Action Potentials; Animals; Cell Size; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; ErbB Receptors; Genistein; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Kinetics; Myocytes, Cardiac; Osmotic Pressure; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Signal Transduction; src-Family Kinases; Tyrphostins; Vanadates | 2008 |
Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.
Topics: Butadienes; Cell Line, Tumor; Cell Movement; CSK Tyrosine-Protein Kinase; Cyclooxygenase 2; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Nitriles; Ovarian Neoplasms; Pertussis Toxin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrimidines; Quinazolines; Receptors, Lysophosphatidic Acid; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins | 2008 |
Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death.
Topics: Animals; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Benzimidazoles; Benzodioxoles; Breast Neoplasms; Cell Death; Cell Line, Transformed; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Dasatinib; Female; Fibroblasts; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Protease Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Pyrimidines; Quinazolines; Radiation Tolerance; src-Family Kinases; Thiazoles | 2011 |
Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation.
Topics: beta-Cyclodextrins; Caveolin 1; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Inhibitors; ErbB Receptors; Humans; MAP Kinase Kinase Kinases; Ouabain; Phosphorylation; Polycystic Kidney, Autosomal Dominant; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-fyn; Pyrimidines; Quinazolines; Signal Transduction; Sodium-Potassium-Exchanging ATPase; src-Family Kinases; Tyrphostins | 2011 |
Erlotinib antagonizes constitutive activation of SRC family kinases and mTOR in acute myeloid leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Biomarkers, Tumor; Enzyme Activation; Erlotinib Hydrochloride; Flow Cytometry; G1 Phase Cell Cycle Checkpoints; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Microscopy, Electron; Microscopy, Fluorescence; Microtubule-Associated Proteins; Phosphorylation; Pyrimidines; Quinazolines; Signal Transduction; Sirolimus; src-Family Kinases; Stilbenes; TOR Serine-Threonine Kinases | 2011 |
VEGFR2 signalling contributes to increased endothelial susceptibility to TNF-α under chronic non-uniform shear stress.
Topics: Active Transport, Cell Nucleus; Blotting, Western; Cell Adhesion; Cells, Cultured; Chromones; Coculture Techniques; Dose-Response Relationship, Drug; E-Selectin; Fluorescent Antibody Technique; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Mechanotransduction, Cellular; Monocytes; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; RNA Interference; src-Family Kinases; Stress, Mechanical; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts.
Topics: Acetophenones; Adult; Amino Acid Chloromethyl Ketones; Benzopyrans; Chemokine CCL2; Enzyme Inhibitors; ErbB Receptors; Humans; Middle Aged; Osteoblasts; Protein Kinase C; Pyrimidines; Quinazolines; Receptor, PAR-1; Signal Transduction; src-Family Kinases; Thrombin; Transcriptional Activation; Tyrphostins | 2012 |
RIP2/RICK-dependent cytokine production upon Yersinia enterocolitica infection in macrophages with TLR4 deficiency.
Topics: Animals; Enzyme Inhibitors; Gefitinib; Imidazoles; Interleukin-10; Interleukin-6; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Nod1 Signaling Adaptor Protein; Nod2 Signaling Adaptor Protein; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinazolines; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Yersinia enterocolitica; Yersinia Infections | 2013 |
Dysregulated activation of c-Src in gestational trophoblastic disease contributes to its aggressive progression.
Topics: Benzodioxoles; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chorionic Gonadotropin; Enzyme Inhibitors; Female; Gestational Trophoblastic Disease; Humans; Pregnancy; Pyrimidines; Quinazolines; src-Family Kinases | 2014 |
CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dipeptides; ErbB Receptors; Gastrins; Gefitinib; Hormone Antagonists; Humans; Indoles; Lung Neoplasms; Meglumine; Pyrimidines; Quinazolines | 2015 |
Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2.
Topics: Blotting, Western; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Prostate; Prostatic Hyperplasia; Pyrimidines; Quinazolines; Real-Time Polymerase Chain Reaction; src-Family Kinases; Stromal Cells | 2016 |