quinazolines has been researched along with adenosine in 102 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (5.88) | 18.7374 |
| 1990's | 42 (41.18) | 18.2507 |
| 2000's | 42 (41.18) | 29.6817 |
| 2010's | 11 (10.78) | 24.3611 |
| 2020's | 1 (0.98) | 2.80 |
| Authors | Studies |
|---|---|
| Leonard, NJ; Morrice, AG; Sprecker, MA | 1 |
| O'Regan, MH; Perkins, LM; Phillis, JW; Simpson, RE | 1 |
| Cox, BF; Lappe, RW; Sheldon, JH | 1 |
| Adén, U; Fredholm, BB; Johansson, B; Lindström, K; Svenningsson, P | 1 |
| Abels, BC; Branch, RA; Callis, JT; Sabra, R | 1 |
| Araki, T; Hara, H; Kato, H; Kogure, K; Onodera, H | 1 |
| Barraco, RA; Phillis, JW | 1 |
| Holtzman, SG; Mumford, GK | 1 |
| Holtzman, SG | 1 |
| Czuczwar, SJ; Janusz, W; Kleinrok, Z; Szczepanik, B | 1 |
| Do, UH; Jarvis, MF; Sills, MA; Williams, M | 1 |
| Bourguignon, JJ; Griebel, G; Misslin, R; Remmy, D; Saffroy-Spittler, M; Vogel, E | 1 |
| Brown, GL; Douglas, FL; Kotake, AN; Mustafa, SJ; Sabouni, MH | 1 |
| Behnke, N; Müller, W; Neumann, J; Schmitz, W; Scholz, H; Stein, B | 1 |
| Gewirtz, H; Mills, I | 1 |
| Imai, S; Ishibashi, T; Nakazawa, M | 1 |
| Abels, BC; Branch, KR; Branch, RA; Callis, JT; Jackson, EK; Kuan, CJ; Sabra, R | 1 |
| Braunwalder, A; Cash, WD; Francis, J; Ghai, G; Psychoyos, S; Stone, GA; Williams, M | 1 |
| Atkins, C; Cash, WD; Francis, JE; Friedmann, RC; Furness, P; Ghai, G; Hyun, JL; Psychoyos, S; Warren, V; Wenk, P | 1 |
| Cote, DT; Dotson, RA; Francis, JE; Ghai, G; Goodman, FR; Hopkins, MF; Williams, M; Zimmerman, MB | 1 |
| Amoroso, S; Annunziato, L; Di Renzo, G; Iannotti, E; Saggese, ML | 1 |
| Howell, LL; Landrum, AM | 1 |
| Imaizumi, M; Miyazaki, S; Onodera, K | 1 |
| Cazin, L; Mei, YA; Vaudry, H | 1 |
| Jarvis, JE; Reeves, JJ; Sheehan, MJ; Strong, P | 1 |
| Borchard, U; Felsch, A; Stöcker, K | 1 |
| Patel, M; Sheehan, MJ; Strong, P | 1 |
| Schmitz, W; Scholz, H; Seeland, C; Stein, B | 1 |
| Conti, A; Dionisotti, S; Gatta, F; Ongini, E; Sandoli, D; Zocchi, C | 1 |
| Currin, RT; Lemasters, JJ; Lichtman, SN; Reinstein, LJ; Thurman, RG; Wang, J | 1 |
| Kroll, K; Schrader, J | 1 |
| Ahlberg, S; Fredholm, BB; Olsson, RA; Parkinson, FE; van der Ploeg, I | 1 |
| Baraldi, PG; Dionisotti, S; Ferrara, S; Ongini, E; Zocchi, C | 1 |
| Dobson, JG; Fenton, RA; Sawmiller, DR | 1 |
| Jacobson, KA; Ji, XD; Kim, YC | 1 |
| Anderson, GF; Barraco, RA; Helfman, CC | 1 |
| Dobson, JG; Ethier, MF | 1 |
| Abbracchio, MP; Jacobson, KA; Jiang, JL; Kim, YC; Sei, Y; Yao, Y | 1 |
| Jones, CA; Reeves, JJ; Sheehan, MJ; Vardey, CJ; Whelan, CJ | 1 |
| Arteaga, CL; Guyer, CA; Ramsey, TT; Shawver, LK | 1 |
| Alexander, SP; Cooper, J; Hill, SJ | 1 |
| Jacobson, KA; Ji, XD; Jiang, JL; Kim, YC; Olah, ME; Park, KS; Stiles, GL | 1 |
| Baraldi, PG; Borea, PA; Cacciari, B; Dionisotti, S; Ongini, E; Varani, K | 1 |
| Glenn, JR; Heptinstall, S | 1 |
| Cutler, BS; Dobson, JG; Fenton, RA; Li, Jm; Peyton, BD; Powell, CC; Wheeler, HB | 1 |
| Hata, K; Kloner, RA; Przyklenk, K; Whittaker, P | 1 |
| Fredholm, BB; Lindström, K | 1 |
| Borgeat, P; Bourgoin, SG; Harbour, D; Naccache, PH; Thibault, N | 1 |
| Gean, PW; Lu, KT; Wu, SP | 1 |
| Abbracchio, MP; Barbieri, D; Brambilla, R; Cattabeni, F; Ceruti, S; Franceschi, C; Jacobson, KA; Kim, YC; Klotz, KN; Lohse, MJ | 1 |
| Bar-Yehuda, S; Barer, F; Farbstein, T; Fishman, P; Ohana, G | 1 |
| Brand, A; Eschke, D; Nieber, K; Vissiennon, Z | 1 |
| Khoo, HE; Mittal, RA; Tan, CH | 1 |
| Coyne, EF; Meno, JR; Ngai, AC; West, GA; Winn, HR | 1 |
| Chen, Y; Hertz, L; Rathbone, MP | 1 |
| Boon, K; Fooks, HM; Hourani, SM; Prentice, DJ | 1 |
| Hamann, M; Richter, A | 1 |
| Baldwin, SA; Cass, CE; Duszyk, M; Man, SF; Ng, AM; Sawicka, J; Szkotak, AJ; Young, JD | 1 |
| Ashton, K; Berr, SS; Cerniway, RJ; Harrison, GJ; Headrick, JP; Paul Matherne, G; Peart, J; Regan, S | 1 |
| Karasawa, A; Kusaka, H; Mizutani, M; Noji, T; Okamura, Y; Takai, H; Takayama, M | 1 |
| Ijzerman, AP; Timmerman, H; van Muijlwijk-Koezen, JE | 1 |
| Jacobson, KA; Jacobson, MA; Ledent, C; Morrison, RR; Mustafa, SJ; Talukder, MA | 1 |
| Bivalacqua, TJ; Champion, HC; Kadowitz, PJ; Lambert, DG | 1 |
| Karasawa, A; Kusaka, H; Nishikawa, S; Noji, T; Sano, J; Sato, H | 1 |
| Le Crom, S; Prou, D; Vernier, P | 1 |
| Cohen, MV; Downey, JM; Krieg, T; McIntosh, EC; Qin, Q | 1 |
| Karasawa, A; Katagiri, C; Kusaka, H; Mizutani, M; Nan-ya, K; Nishikawa, S; Noji, T; Sano, J; Takada, C | 1 |
| Karasawa, A; Katagiri, C; Kusaka, H; Mizutani, M; Nan-ya, K; Nishikawa, S; Noji, T; Sano, J | 1 |
| Ezeamuzie, CI; Philips, E | 1 |
| Feldkamp, T; Heemann, U; Herget-Rosenthal, S; Horbelt, M; Kribben, A; Lange, B; Philipp, T; Pietruck, F | 1 |
| Saccone, GT; Toouli, J; Woods, CM | 1 |
| Hague, BF; Kindt, TJ; Zhao, TM | 1 |
| Karasawa, A; Kusaka, H; Noji, T | 1 |
| O'Regan, MH; Phillis, JW | 1 |
| Archer, RG; Hammond, JR | 1 |
| Baharav, E; Bar-Yehuda, S; Fishman, P; Halpren, M; Madi, L; Ochaion, A; Rath-Wolfson, L; Silberman, D; Weinberger, A | 1 |
| Baba, K; Fujiwara, H; Kariya, T; Kawai, T; Minatoguchi, S; Takahashi, M; Takemura, G; Uno, Y; Zhang, C | 1 |
| Andrisani, OM; Bilodeau, ML; Ji, M; Paris, M | 1 |
| Sladek, CD; Song, Z | 1 |
| Cavalheiro, EA; da Silva Fernandes, MJ; Doná, F; Ferreira, AT; Vianna, EP | 1 |
| Cortés, D; Díaz-Cruz, A; Guinzberg, R; Piña, E; Riveros-Rosas, H; Villalobos-Molina, R | 1 |
| Bennett, MR; Lin, YQ | 1 |
| Broadley, KJ; Clark, JH; James, S; Kidd, EJ; Martin, TJ; Yates, L | 1 |
| Mulè, F; Serio, R; Zizzo, MG | 1 |
| Gao, C; Gao, N; Hu, HZ; Liu, S; Wood, JD; Xia, Y | 1 |
| Coe, IR; Naydenova, Z; Rose, JB | 1 |
| Arcella, A; Cantore, G; Di Gennaro, G; Esposito, V; Eusebi, F; Fredholm, BB; Fucile, S; Limatola, C; Manfredi, M; Martinello, K; Mascia, A; Miledi, R; Piccari, V; Quarato, PP; Roseti, C; Simonato, M | 1 |
| Chen, G; Liu, BR; Xie, L | 1 |
| Miriel, VA; Rivers, RJ; Thengchaisri, N | 1 |
| Aung, HH; Barnholt, KE; Kota, RS; Rutledge, JC | 1 |
| Faldyna, M; Kovaru, F; Kovaru, H; Leva, L; Matiasovic, J; Ondrackova, P | 1 |
| Atadja, P; Fan, H; Frederiksen, M; Gao, J; Gu, XJ; Guo, W; Harrington, E; Jiang, L; Li, E; Li, S; Lin, Y; Lu, C; Meier, P; Scheufler, C; Wang, Z; Xu, YC; Zhao, K; Zhou, S | 1 |
| Catar, R; Chaykovska, L; Dragun, D; Fuller, TF; Haller, M; Hoff, U; Kusch, A; Pützer, J; Troppmair, J | 1 |
| Burton, VJ; Butler, M; Parkinson, SJ; Pearson, R; Sanmugalingam, D; Smith, P; Watson, RP; Wilson, T | 1 |
| Ambudkar, SV; Bakhsheshian, J; Chang, KE; Gottesman, MM; Hall, MD; Shukla, S; Simpson, RM; Wei, BR | 1 |
| Kaminska, B; Maleszewska, M; Steranka, A | 1 |
| Birnbaum, Y; Kodakandla, M; Ling, S; Nanhwan, MK; Nylander, S; Ye, Y | 1 |
| Assaraf, YG; Azzariti, A; Giovannetti, E; Jansen, G; Kathman, I; Paradiso, A; Peters, GJ; Porcelli, L; Scheffer, GL | 1 |
| Geutskens, SB; Goedhart, M; Haasnoot, GW; Miggelbrink, XM; Muggen, AF; van den Elsen, PJ; van Eggermond, MC; van Zwet, E; Wierda, RJ | 1 |
| Bekerman, E; Einav, S | 1 |
| Chen, WL; Guo, XK; Li, DD; Sun, HP; Wang, ZH; You, QD | 1 |
| Chang, P; Chen, J; Gao, L; Li, J; Liu, F; Liu, X; Lu, M; Tang, H; Tang, Y; Wang, H; Yao, L | 1 |
4 review(s) available for quinazolines and adenosine
| Article | Year |
|---|---|
The adenosine A3 receptor and its ligands.
Topics: Adenosine; Amino Acid Sequence; Animals; Cardiovascular Diseases; Cloning, Molecular; Flavonoids; Humans; Immune System Diseases; Lung Diseases; Models, Animal; Molecular Sequence Data; Protein Binding; Pyrans; Pyridines; Quinazolines; Receptors, Purinergic; Sequence Alignment; Species Specificity; Triazoles; Xanthines | 2001 |
[Pharmacological study on the effects of the adenosine uptake inhibitor KF24345 on inflammatory diseases].
Topics: Acute Disease; Adenosine; Animals; Depression, Chemical; Erythrocytes; Glomerulonephritis; Humans; Inflammation; Leukopenia; Lipopolysaccharides; Mice; Neurotransmitter Uptake Inhibitors; Pancreatitis; Pyrimidinones; Quinazolines; Tumor Necrosis Factor-alpha | 2003 |
[Stem cell-targeted therapy--a new strategy for cancer treatment].
Topics: Adenosine; Animals; Antineoplastic Agents; ATP-Binding Cassette Transporters; Biomarkers, Tumor; Cell Differentiation; Diketopiperazines; Heterocyclic Compounds, 4 or More Rings; Humans; Lapatinib; Neoplasms; Neoplastic Stem Cells; Protein Kinase Inhibitors; Pyrimidinones; Quinazolines; Signal Transduction; Triazines; Wnt Proteins | 2008 |
G9a - An Appealing Antineoplastic Target.
Topics: Adenosine; Animals; Antineoplastic Agents; Azepines; Benzimidazoles; DNA Methylation; Enzyme Inhibitors; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Molecular Targeted Therapy; Quinazolines | 2017 |
1 trial(s) available for quinazolines and adenosine
| Article | Year |
|---|---|
Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Chemotaxis; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Immunity, Innate; Inflammation; Mice; Mice, Knockout; Neutrophils; Quinazolines; Receptor, Adenosine A3; Triazoles; Up-Regulation | 2012 |
97 other study(ies) available for quinazolines and adenosine
| Article | Year |
|---|---|
Defined dimensional changes in enzyme substrates and cofactors. Synthesis of lin-benzoadenosine and enzymatic evaluation of derivatives of the benzopurines.
Topics: Adenosine; Chemical Phenomena; Chemistry; Purine-Nucleoside Phosphorylase; Quinazolines; Spectrum Analysis | 1976 |
Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Purinergic Antagonists; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Triazoles; Xanthines | 1992 |
Selective adenosine-2 agonist produces both direct and reflex tachycardia in normotensive rats.
Topics: Adenosine; Adrenergic beta-Antagonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Heart Rate; Male; Purinergic Antagonists; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Sympathetic Nervous System; Triazoles; Vascular Resistance | 1992 |
Evidence that the increase in striatal c-fos following acute high-dose caffeine is not due to direct interaction with striatal adenosine receptors.
Topics: Adenosine; Animals; Caffeine; Corpus Striatum; Dose-Response Relationship, Drug; Genes, fos; Purinergic Antagonists; Quinazolines; Rats; RNA, Messenger; Triazoles; Xanthines | 1992 |
Influence of the adenosine receptor antagonist, CGS 15943A, on renal function after reconstruction of chronic renal artery stenosis in the dog.
Topics: Adenosine; Animals; Constriction, Pathologic; Creatinine; Dogs; Hemodynamics; Kidney; Purinergic Antagonists; Quinazolines; Renal Artery; Renal Circulation; Triazoles | 1992 |
Involvement of lipid peroxidation and inhibitory mechanisms on ischemic neuronal damage in gerbil hippocampus: quantitative autoradiographic studies on second messenger and neurotransmitter systems.
Topics: Adenosine; Animals; Autoradiography; Body Temperature; Brain Ischemia; Calcium Channels; Chlorides; Colforsin; Gerbillinae; Hippocampus; Inositol 1,4,5-Trisphosphate; Ion Channels; Lipid Peroxidation; Male; Neurons; Neurotransmitter Agents; Pentobarbital; Phorbol 12,13-Dibutyrate; Quinazolines; Quinuclidinyl Benzilate; Receptors, GABA-A; Second Messenger Systems | 1991 |
Subtypes of adenosine receptors in the brainstem mediate opposite blood pressure responses.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Dose-Response Relationship, Drug; Male; Phenethylamines; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Triazoles; Xanthines | 1991 |
Do adenosinergic substrates mediate methylxanthine effects upon reinforcement thresholds for electrical brain stimulation in the rat?
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Carbolines; Chlordiazepoxide; Electric Stimulation; Hypothalamic Area, Lateral; Male; Midazolam; Phenylisopropyladenosine; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Reinforcement, Psychology; Self Stimulation; Sensory Thresholds; Theophylline; Triazoles | 1991 |
CGS 15943, a nonxanthine adenosine receptor antagonist: effects on locomotor activity of nontolerant and caffeine-tolerant rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Motor Activity; Quinazolines; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Influence of CGS 15943 A (a nonxanthine adenosine antagonist) on the protection offered by a variety of antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Adenosine; Animals; Anticonvulsants; Disease Susceptibility; Drug Interactions; Electroshock; Epilepsy; Male; Mice; Motor Activity; Quinazolines; Triazoles | 1991 |
Characterization of the binding of a novel nonxanthine adenosine antagonist radioligand, [3H]CGS 15943, to multiple affinity states of the adenosine A1 receptor in the rat cortex.
Topics: 2-Chloroadenosine; Adenosine; Animals; Binding, Competitive; Cerebral Cortex; Dose-Response Relationship, Drug; Phenylisopropyladenosine; Purinergic Antagonists; Pyrazoles; Quinazolines; Rats; Receptors, Purinergic; Triazoles; Tritium | 1991 |
Comparison of the behavioural effects of an adenosine A1/A2-receptor antagonist, CGS 15943A, and an A1-selective antagonist, DPCPX.
Topics: Adenosine; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Mice; Motor Activity; Purinergic Antagonists; Quinazolines; Triazoles; Xanthines | 1991 |
Effects of CGS-15943A on the relaxations produced by adenosine analogs in human blood vessels.
Topics: Adenosine; Adult; Coronary Vessels; Humans; In Vitro Techniques; Mammary Arteries; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Chloride; Quinazolines; Saphenous Vein; Theophylline; Triazoles | 1990 |
Differential antagonism by 1,3-dipropylxanthine-8-cyclopentylxanthine and 9-chloro-2-(2-furanyl)-5,6-dihydro-1,2,4-triazolo(1,5-c)quinazolin-5-im ine of the effects of adenosine derivatives in the presence of isoprenaline on contractile response and cycli
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cyclic AMP; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Heart; Isoproterenol; Male; Myocardial Contraction; Quinazolines; Receptors, Purinergic; Triazoles; Vasodilator Agents; Xanthines | 1990 |
Cultured vascular smooth muscle cells from porcine coronary artery possess A1 and A2 adenosine receptor activity.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Analysis of Variance; Animals; Cells, Cultured; Coronary Vessels; Muscle, Smooth, Vascular; Phenylisopropyladenosine; Quinazolines; Receptors, Purinergic; Swine; Triazoles | 1990 |
Effect of MCI-176, a new calcium channel blocker, on large and small coronary arteries in dogs.
Topics: Adenosine; Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Male; Quinazolines; Quinazolinones; Vascular Resistance; Vasodilator Agents | 1989 |
Inhibition of renal vasoconstriction induced by intrarenal hypertonic saline by the nonxanthine adenosine antagonist CGS 15943A.
Topics: Adenosine; Animals; Dogs; Quinazolines; Receptors, Purinergic; Renal Circulation; Saline Solution, Hypertonic; Sodium Chloride; Theophylline; Triazoles; Vasoconstriction | 1989 |
Biochemical characterization of the triazoloquinazoline, CGS 15943, a novel, non-xanthine adenosine antagonist.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Brain; Guinea Pigs; Kinetics; Neurotransmitter Agents; Pyrazoles; Quinazolines; Rats; Receptors, Purinergic; Triazoles; Xanthines | 1987 |
Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists.
Topics: Adenosine; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Molecular Conformation; Muscle, Smooth; Quinazolines; Rats; Receptors, Purinergic; Structure-Activity Relationship; Triazoles | 1988 |
Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist.
Topics: 2-Chloroadenosine; Adenosine; Animals; Blood Pressure; Coronary Vessels; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Trachea; Triazoles | 1987 |
The A1 agonist CCPA reduced bisoxonol-monitored membrane potential depolarization elicited by high K+ in cerebrocortical nerve endings.
Topics: Adenosine; Animals; Cerebral Cortex; Fluorescent Dyes; Male; Membrane Potentials; Nerve Endings; Phenethylamines; Potassium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Synaptosomes; Thiobarbiturates; Triazoles; Veratridine; Xanthines | 1995 |
Attenuation of hypoxia-induced increases in ventilation by adenosine antagonists in rhesus monkeys.
Topics: Adenosine; Animals; Hypoxia; Macaca mulatta; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinazolines; Respiration; Rolipram; Triazoles | 1995 |
Effects of a non-xanthine adenosine antagonist, CGS 15943, and a phosphodiesterase inhibitor, Ro 20-1724, in a light/dark test in mice.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Animals; Anxiety; Darkness; Light; Male; Mice; Mice, Inbred ICR; Motor Activity; Phosphodiesterase Inhibitors; Quinazolines; Triazoles | 1994 |
Inhibitory effect of adenosine on electrical activity of frog melanotrophs mediated through A1 purinergic receptors.
Topics: Action Potentials; Adenosine; alpha-MSH; Animals; Cells, Cultured; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Male; Membrane Potentials; Patch-Clamp Techniques; Pertussis Toxin; Phenylisopropyladenosine; Pituitary Gland; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Quinazolines; Rana ridibunda; Tachyphylaxis; Theophylline; Triazoles; Virulence Factors, Bordetella | 1994 |
Further investigations into adenosine A1 receptor-mediated contraction in rat colonic muscularis mucosae and its augmentation by certain alkylxanthine antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colon; Cyclooxygenase Inhibitors; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Muscle Contraction; Muscle, Smooth; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Theophylline; Triazoles; Vasodilator Agents; Xanthines | 1995 |
Adenosine A1 and A2 receptor agonists alter cardiac functions and prostacyclin release in the isolated guinea-pig heart.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Animals; Antihypertensive Agents; Cardiac Pacing, Artificial; Cells, Cultured; Coronary Circulation; Dose-Response Relationship, Drug; Endothelium, Vascular; Epoprostenol; Guinea Pigs; Heart; Heart Rate; Male; Myocardium; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Triazoles; Vasodilation; Ventricular Function, Left; Xanthines | 1994 |
Failure of CGS15943A to block the hypotensive action of agonists acting at the adenosine A3 receptor.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Female; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Triazoles | 1994 |
Pharmacological characterization of A2-adenosine receptors in guinea-pig ventricular cardiomyocytes.
Topics: Adenosine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cells, Cultured; Cyclic AMP; Drug Interactions; Female; Guinea Pigs; Heart Ventricles; Isoproterenol; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Pertussis Toxin; Phenethylamines; Quinazolines; Receptors, Adrenergic, beta; Receptors, Purinergic P1; Signal Transduction; Triazoles; Virulence Factors, Bordetella; Xanthines | 1994 |
Effects of the new A2 adenosine receptor antagonist 8FB-PTP, an 8 substituted pyrazolo-triazolo-pyrimidine, on in vitro functional models.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cattle; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Phosphoric Diester Hydrolases; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Rabbits; Rats; Rats, Sprague-Dawley; Triazoles; Vasodilator Agents; Xanthines | 1994 |
Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: evidence for A2 receptors on rat Kupffer cells.
Topics: Adenosine; Alprostadil; Animals; Bucladesine; Cells, Cultured; Cyclic AMP; Kupffer Cells; Lipopolysaccharides; Nisoldipine; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazoles; Tumor Necrosis Factor-alpha; Xanthines | 1994 |
Myocardial adenosine stimulates release of cyclic adenosine monophosphate from capillary endothelial cells in guinea pig heart.
Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Alprostadil; Animals; Capillaries; Coronary Vessels; Cyclic AMP; Endothelium, Vascular; Guinea Pigs; Myocardium; Oxygen; Procaterol; Quinazolines; Theophylline; Triazoles; Vasodilation | 1993 |
Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Colforsin; Cyclic AMP; DNA; Humans; Isotope Labeling; Lethal Dose 50; Leukemia, T-Cell; Molecular Sequence Data; PC12 Cells; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Quinazolines; Rats; Receptors, Purinergic P1; RNA, Messenger; Triazoles; Tumor Cells, Cultured | 1996 |
Binding of the radioligand [3H]-SCH 58261, a new non-xanthine A2A adenosine receptor antagonist, to rat striatal membranes.
Topics: Adenosine; Animals; Binding, Competitive; Corpus Striatum; In Vitro Techniques; Kinetics; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazoles; Tritium | 1996 |
Myocardial adenosine A1 and A2 receptor activities during juvenile and adult stages of development.
Topics: Adenosine; Aging; Animals; Coronary Vessels; Drug Synergism; Heart; Isoproterenol; Male; Myocardial Contraction; Myocardium; Osmolar Concentration; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazoles; Veins; Xanthines | 1996 |
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.
Topics: Adenosine; Affinity Labels; Animals; Binding Sites; Binding, Competitive; Cell Line; Cerebral Cortex; Corpus Striatum; Humans; Magnetic Resonance Spectroscopy; Quinazolines; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Substrate Specificity; Triazoles | 1996 |
Augmented release of serotonin by adenosine A2a receptor activation and desensitization by CGS 21680 in the rat nucleus tractus solitarius.
Topics: Adenosine; Animals; In Vitro Techniques; Kinetics; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Serotonin; Solitary Nucleus; Triazoles; Xanthines | 1996 |
Adenosine stimulation of DNA synthesis in human endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Endothelium, Vascular; Humans; Kinetics; Poly A; Purinergic P1 Receptor Antagonists; Quinazolines; Tetradecanoylphorbol Acetate; Thioinosine; Thionucleotides; Thymidine; Triazoles; Umbilical Veins | 1997 |
Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists.
Topics: Adenosine; Apoptosis; Dihydropyridines; DNA Fragmentation; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazoles; Quinazolines; Triazoles | 1997 |
Adenosine A3 receptors promote degranulation of rat mast cells both in vitro and in vivo.
Topics: Adenosine; Administration, Cutaneous; Animals; Blood Proteins; Cell Degranulation; Cyproheptadine; Dinitrophenols; Female; Humans; In Vitro Techniques; Injections, Intravenous; Male; Mast Cells; Mice; p-Methoxy-N-methylphenethylamine; Pleura; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic P1; Serotonin; Serotonin Antagonists; Serum Albumin; Skin; Theophylline; Triazoles; Xanthines | 1997 |
Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site.
Topics: Adenosine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Binding Sites; Carrier Proteins; Dimerization; Enzyme Inhibitors; ErbB Receptors; Glycoproteins; Humans; Ligands; Neuregulin-1; Nitriles; Phosphorylation; Protein Binding; Protein Conformation; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1997 |
An endogenous A2B adenosine receptor coupled to cyclic AMP generation in human embryonic kidney (HEK 293) cells.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Cells, Cultured; Cyclic AMP; DNA, Complementary; Gene Amplification; Humans; In Vitro Techniques; Kidney; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2B; Receptors, Purinergic P1; Triazoles | 1997 |
Pharmacological characterization of novel A3 adenosine receptor-selective antagonists.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Dihydropyridines; Flavonoids; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Macrophages; Protein Binding; Purinergic P1 Receptor Antagonists; Quinazolines; Radioligand Assay; Receptor, Adenosine A3; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha | 1997 |
Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Kidney; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Transfection; Triazines; Triazoles | 1998 |
Evidence that adenosine diphosphate can activate adenylate cyclase via conversion to adenosine in platelet-rich plasma containing magnesium.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Colforsin; Cyclic AMP; Enzyme Activation; Humans; Iloprost; Magnesium; Platelet Aggregation Inhibitors; Platelet Count; Quinazolines; Receptors, Purinergic P2; Reference Values | 1998 |
Adenosine A2a receptors increase arterial endothelial cell nitric oxide.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Carotid Arteries; Cells, Cultured; Endothelium, Vascular; Humans; Iliac Artery; Nitric Oxide; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Xanthines | 1998 |
Brief myocardial ischemia attenuates platelet thrombosis in remote, damaged, and stenotic carotid arteries.
Topics: Adenosine; Animals; Blood Platelets; Carotid Artery Thrombosis; Carotid Stenosis; Dogs; Myocardial Ischemia; Quinazolines; Rabbits; Receptors, Purinergic P1; Triazoles; Vascular Patency | 1999 |
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines | 1999 |
Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases.
Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); ADP-Ribosylation Factor 1; Adult; Caffeine; Cell Membrane; Enzyme Activation; GTP Phosphohydrolases; Humans; In Vitro Techniques; Isoenzymes; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenethylamines; Phospholipase D; Protein Kinase C; Protein Kinase C-alpha; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; rhoA GTP-Binding Protein; Triazoles | 2000 |
Promotion of forskolin-induced long-term potentiation of synaptic transmission by caffeine in area CA1 of the rat hippocampus.
Topics: Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Central Nervous System Stimulants; Colforsin; Cyclic AMP; Drug Synergism; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Triazoles; Xanthines | 1999 |
Activation of the A3 adenosine receptor affects cell cycle progression and cell growth.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Analysis of Variance; Animals; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Membrane; Cell Survival; CHO Cells; Cricetinae; Dihydropyridines; Flow Cytometry; Humans; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Transfection; Triazoles | 2000 |
Adenosine acts as a chemoprotective agent by stimulating G-CSF production: a role for A1 and A3 adenosine receptors.
Topics: Adenosine; Animals; Bone Marrow Cells; Cell Cycle; Cell Division; Cells, Cultured; Cyclophosphamide; Granulocyte Colony-Stimulating Factor; Humans; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Theobromine; Triazoles; Xanthines | 2000 |
Adenosine A(1) and A(3) receptors mediate inhibition of synaptic transmission in rat cortical neurons.
Topics: Adenosine; Animals; Cerebral Cortex; Drug Interactions; Electric Stimulation; Female; In Vitro Techniques; Male; Neurons; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptor, Adenosine A3; Receptors, Purinergic P1; Synaptic Transmission; Triazoles; Xanthines | 2001 |
Adenosine modulates cell growth in baby hamster kidney (BHK) cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Kinase; Animals; Cell Division; Cell Line; Cricetinae; Enzyme Inhibitors; Kidney; Mutation; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles | 2000 |
Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles.
Topics: Adenosine; Adenosine Triphosphate; Animals; Antihypertensive Agents; Arterioles; Cerebrovascular Circulation; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Phenethylamines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation | 2001 |
Guanosine-induced increase in free cytosolic calcium concentration in mouse astrocytes in primary cultures: does it act on an A3 adenosine receptor?
Topics: Adenosine; Animals; Astrocytes; Brain; Calcium; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Extracellular Space; Guanosine; Mice; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Theophylline; Triazoles; Xanthines | 2001 |
Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Male; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Purinones; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2001 |
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines | 2001 |
Regulation of K(+) current in human airway epithelial cells by exogenous and autocrine adenosine.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine; Affinity Labels; Amiloride; Autocrine Communication; Cell Line; Cell Polarity; Clotrimazole; Diuretics; Epithelial Cells; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Growth Inhibitors; Humans; Membrane Transport Proteins; Patch-Clamp Techniques; Potassium; Potassium Channels; Quinazolines; Receptors, Purinergic P1; Respiratory Mucosa; Theobromine; Thioinosine; Triazoles; Uridine; Xanthines | 2001 |
Effects of A(3) adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart.
Topics: Adenosine; Amino Acids; Animals; Creatine; Heart Rate; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Phenethylamines; Pipecolic Acids; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles; Xanthines | 2002 |
KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice.
Topics: Adenosine; Animals; Cricetinae; Erythrocytes; Humans; Leukopenia; Lipopolysaccharides; Mesocricetus; Mice; Neurotransmitter Uptake Inhibitors; Pyrimidinones; Quinazolines; Rabbits; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha | 2002 |
Targeted deletion of adenosine A(3) receptors augments adenosine-induced coronary flow in isolated mouse heart.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Vessels; Gene Deletion; Heart Rate; Mice; Mice, Knockout; Phenethylamines; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles; Vasodilation; Ventricular Pressure | 2002 |
Vasodilator responses to adenosine and hyperemia are mediated by A(1) and A(2) receptors in the cat vascular bed.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cats; Dose-Response Relationship, Drug; Female; Hemodynamics; Hindlimb; Hyperemia; Male; Perfusion; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Triazoles; Vascular Resistance; Vasodilation; Xanthines | 2002 |
Treatment with an adenosine uptake inhibitor attenuates glomerulonephritis in mice.
Topics: Adenosine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Bilirubin; Cyclophosphamide; Erythrocyte Count; Glomerular Mesangium; Glomerulonephritis; Immunosuppressive Agents; Kidney Function Tests; Kidney Tubules; Male; Mice; Neurotransmitter Uptake Inhibitors; Organ Size; Periodic Acid-Schiff Reaction; Prednisolone; Pyrimidinones; Quinazolines; Rabbits; Spleen; Thymus Gland | 2002 |
Autocrine activation of adenosine A1 receptors blocks D1A but not D1B dopamine receptor desensitization.
Topics: Adenosine; Animals; Autocrine Communication; Cell Line; COS Cells; Cyclic AMP; Dopamine Agonists; Fibroblasts; Mice; Phosphodiesterase Inhibitors; Quinazolines; Receptors, Dopamine D1; Receptors, Dopamine D5; Receptors, Purinergic P1; Time Factors; Transfection; Triazoles; Xanthines | 2002 |
ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases.
Topics: Acetylcholine; Adenosine; Animals; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Female; Heart; In Vitro Techniques; Male; Myocardium; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Rabbits; Receptor Protein-Tyrosine Kinases; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins; Vasodilator Agents | 2002 |
KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice.
Topics: Acute Disease; Adenosine; Amylases; Animals; Choline Deficiency; Diet; Female; L-Lactate Dehydrogenase; Mice; Neurotransmitter Uptake Inhibitors; Organ Size; Pancreas; Pancreatitis; Pyrimidinones; Quinazolines; Time Factors; Tumor Necrosis Factor-alpha | 2002 |
Adenosine uptake inhibition ameliorates cerulein-induced acute pancreatitis in mice.
Topics: Acute Disease; Adenosine; Amylases; Animals; Biological Transport; Ceruletide; Dipyridamole; Female; Lipase; Mice; Mice, Inbred BALB C; Models, Chemical; Pancreatitis; Piperazines; Pyrimidinones; Quinazolines; Theophylline | 2002 |
Positive coupling of atypical adenosine A3 receptors on human eosinophils to adenylyl cyclase.
Topics: Adenosine; Adenylyl Cyclases; Adult; Cell Degranulation; Cyclic AMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Eosinophils; Histamine; Humans; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles | 2003 |
ATP protects, by way of receptor-mediated mechanisms, against hypoxia-induced injury in renal proximal tubules.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Energy Metabolism; Hemolysis; Hypotonic Solutions; Hypoxia; Kidney Tubules, Proximal; Kinetics; L-Lactate Dehydrogenase; Male; Potassium; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Triazoles | 2003 |
A2A and A3 receptors mediate the adenosine-induced relaxation in spontaneously active possum duodenum in vitro.
Topics: Adenosine; Animals; Duodenum; Female; In Vitro Techniques; Male; Opossums; Purinergic P1 Receptor Antagonists; Pyrrolidinones; Quinazolines; Receptors, Purinergic P1; Tetrodotoxin; Time Factors; Triazoles; Xanthines | 2003 |
Binding of HTLV-1 virions to T cells occurs by a temperature and calcium-dependent process and is blocked by certain type 2 adenosine receptor antagonists.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Antibodies, Monoclonal; Calcium; Cations, Divalent; Cell Line, Transformed; Human T-lymphotropic virus 1; Humans; Kinetics; Membrane Microdomains; Phenethylamines; Purinergic P1 Receptor Agonists; Quinazolines; T-Lymphocytes; Thermodynamics; Triazoles | 2003 |
Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation.
Topics: Adenosine; Administration, Inhalation; Animals; Caffeine; Carbon Dioxide; Cerebral Cortex; Cerebral Veins; Cerebrovascular Circulation; Drug Interactions; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Sprague-Dawley; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines | 2003 |
Interaction of the novel adenosine uptake inhibitor 3-[1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1H,3H)-quinazolinedione hydrochloride (KF24345) with the es and ei subtypes of equilibrative nucleoside transporters.
Topics: Adenosine; Allosteric Regulation; Animals; Binding Sites; Biological Transport; Cells, Cultured; Formycins; Humans; Mice; Pyrimidinones; Quinazolines; Rats; Thioinosine; Tritium; Tumor Cells, Cultured | 2004 |
Antiinflammatory effect of A3 adenosine receptor agonists in murine autoimmune arthritis models.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Collagen; Dose-Response Relationship, Drug; Female; Joints; Lymph Nodes; Male; Mice; Mice, Inbred DBA; Quinazolines; Rats; Receptor, Adenosine A3; Spleen; Triazoles; Tumor Necrosis Factor-alpha | 2005 |
Alpha1-receptor or adenosine A1-receptor dependent pathway alone is not sufficient but summation of these pathways is required to achieve an ischaemic preconditioning effect in rabbits.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Enzyme Inhibitors; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Protein Kinase C; Quinazolines; Rabbits; Receptor, Adenosine A1; Receptors, Adrenergic, alpha-1; Staurosporine; Theophylline; Tyramine; Vasodilator Agents | 2005 |
Adenosine signaling promotes neuronal, catecholaminergic differentiation of primary neural crest cells and CNS-derived CAD cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine-5'-(N-ethylcarboxamide); Adrenal Medulla; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Catecholamines; Cell Differentiation; Cell Line; Cells, Cultured; Chromaffin Cells; Coturnix; Culture Media, Serum-Free; Cyclic AMP; Neural Crest; Neurons; Quinazolines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Signal Transduction; Sympathetic Nervous System; Transforming Growth Factor beta; Triazoles; Tyrosine 3-Monooxygenase | 2005 |
Does conversion of ATP to adenosine terminate ATP-stimulated vasopressin release from hypothalamo-neurohypophyseal explants?
Topics: 5'-Nucleotidase; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Triphosphate; Animals; Enzyme Inhibitors; Hypothalamo-Hypophyseal System; Male; Organ Culture Techniques; Pituitary Gland, Posterior; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Purinergic P1; Supraoptic Nucleus; Time Factors; Triazoles; Vasopressins; Water-Electrolyte Balance; Xanthines | 2005 |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Topics: 5'-Nucleotidase; Adenosine; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; In Situ Nick-End Labeling; Male; Neuronal Plasticity; Neuroprotective Agents; Pilocarpine; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic P1; Status Epilepticus; Synapses; Triazoles; Xanthines | 2005 |
Inosine released after hypoxia activates hepatic glucose liberation through A3 adenosine receptors.
Topics: Adenosine; Adenosine A3 Receptor Antagonists; Animals; Calcium; Cell Hypoxia; Cyclic AMP; Gluconeogenesis; Glucose; Glycogen Phosphorylase; Glycogenolysis; Hepatocytes; Inosine; Liver; Male; Phylogeny; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptor, Adenosine A3; Receptors, G-Protein-Coupled; Receptors, Purinergic; Receptors, Purinergic P1; Triazoles; Urea | 2006 |
Schwann cells in rat vascular autonomic nerves activated via purinergic receptors.
Topics: Adenosine; Adenosine Triphosphate; Animals; Autonomic Nervous System; Calcium; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic; Schwann Cells; Splanchnic Circulation; Suramin; Triazoles; Uridine Triphosphate | 2006 |
Radioligand binding and functional responses of ligands for human recombinant adenosine A(3) receptors.
Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Iodine Radioisotopes; Ligands; Magnesium Chloride; Quinazolines; Radioligand Assay; Receptor, Adenosine A3; Recombinant Proteins; Transfection; Triazoles | 2006 |
Inhibitory responses to exogenous adenosine in murine proximal and distal colon.
Topics: Adenosine; Animals; Colon; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Signal Transduction; Theobromine; Triazoles; Xanthines | 2006 |
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Boron Compounds; Enzyme Inhibitors; Estrenes; Excitatory Postsynaptic Potentials; Guinea Pigs; Ileum; Indoles; Male; Maleimides; Norepinephrine; Phenethylamines; Pyrrolidinones; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Signal Transduction; Submucous Plexus; Synaptic Transmission; Tetrodotoxin; Theophylline; Triazines; Triazoles | 2007 |
Inosine and equilibrative nucleoside transporter 2 contribute to hypoxic preconditioning in the murine cardiomyocyte HL-1 cell line.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Cell Hypoxia; Cell Line; Cell Survival; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Inosine; Mice; Myocytes, Cardiac; Nucleoside Transport Proteins; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A3; Thioinosine; Triazoles; Up-Regulation; Xanthines | 2008 |
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
Topics: Adenosine; Adenosine Deaminase; Adult; Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Male; Neurons; Oocytes; Purinergic P1 Receptor Antagonists; Pyramidal Tracts; Pyrimidines; Quinazolines; Rats; Receptors, GABA-A; Triazoles; Xanthines; Xenopus | 2008 |
Multiple receptor subtypes and multiple mechanisms of dilation are involved in vascular network dilation caused by adenosine.
Topics: Adenosine; Animals; Arterioles; Cricetinae; Drug Antagonism; Endothelium, Vascular; Flavins; Mesocricetus; Methacholine Chloride; Nitroprusside; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 2009 |
Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation.
Topics: Adenosine; Adenosine A3 Receptor Antagonists; Analgesics; Animals; Cell Line; Dihydropyridines; Gene Expression; Humans; Interferon-gamma; Janus Kinases; Macrophage Activation; Macrophages; Mice; Microarray Analysis; Phosphorylation; Quinazolines; Receptor, Adenosine A3; Serine; Signal Transduction; STAT1 Transcription Factor; Transcriptional Activation; Triazoles; Tyrosine | 2009 |
The effect of adenosine on pro-inflammatory cytokine production by porcine T cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Concanavalin A; Dose-Response Relationship, Drug; Flow Cytometry; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-2; Quinazolines; Swine; T-Lymphocyte Subsets; T-Lymphocytes; Triazoles; Tumor Necrosis Factor-alpha | 2012 |
Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay.
Topics: Adenosine; Azepines; Catalytic Domain; Chromatography, High Pressure Liquid; Fluorescent Dyes; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Kinetics; Protein Binding; Quinazolines; Recombinant Proteins; S-Adenosylhomocysteine; Tandem Mass Spectrometry; Time Factors | 2012 |
Protein kinase C inhibition ameliorates posttransplantation preservation injury in rat renal transplants.
Topics: Adenosine; Allopurinol; Animals; Apoptosis; Biomarkers; Blotting, Western; Cell Proliferation; Cold Temperature; Creatinine; Cytokines; Cytoprotection; Delayed Graft Function; Glutathione; Immunohistochemistry; Inflammation Mediators; Insulin; Kidney; Kidney Transplantation; Male; Mycophenolic Acid; Organ Preservation; Organ Preservation Solutions; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Raffinose; Rats; Rats, Inbred Lew; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Signal Transduction; Time Factors | 2012 |
Bioluminescent imaging of drug efflux at the blood-brain barrier mediated by the transporter ABCG2.
Topics: 3T3 Cells; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Cell Line, Tumor; Diketopiperazines; Endothelial Cells; Firefly Luciferin; Gefitinib; Gene Expression; HEK293 Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Luciferases, Firefly; Luminescent Agents; Luminescent Measurements; Mice; Mice, Transgenic; Neoplasm Proteins; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Xenobiotics | 2013 |
The effects of selected inhibitors of histone modifying enzyme on C6 glioma cells.
Topics: Acetylation; Adenosine; Animals; Azepines; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Epigenesis, Genetic; Glioma; Histones; Hydroxamic Acids; Piperazines; Quinazolines; Rats; Valproic Acid | 2014 |
Chronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Aspirin; Cardiotonic Agents; Clopidogrel; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Evaluation, Preclinical; Enzyme Induction; Lipoxins; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type III; Pyrazoles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Ticagrelor; Ticlopidine; Triazoles; Up-Regulation | 2014 |
The EGFR pathway regulates BCRP expression in NSCLC cells: role of erlotinib.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Membrane; Chromones; Cytoplasm; Diketopiperazines; ErbB Receptors; Erlotinib Hydrochloride; Heterocyclic Compounds, 4 or More Rings; Humans; Lung Neoplasms; Morpholines; Neoplasm Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction | 2014 |
A role for KMT1c in monocyte to dendritic cell differentiation: Epigenetic regulation of monocyte differentiation.
Topics: Acetylation; Adenosine; Azepines; Cell Adhesion Molecules; Cell Differentiation; Chromatin; Chromatin Assembly and Disassembly; Dendritic Cells; Epigenesis, Genetic; Gene Expression Profiling; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Lectins, C-Type; Methylation; Monocytes; Primary Cell Culture; Quinazolines; Receptors, Cell Surface; Signal Transduction; Transcription, Genetic | 2015 |
Infectious disease. Combating emerging viral threats.
Topics: Adenine; Adenosine; Antiviral Agents; Benzamides; Chloroquine; Communicable Diseases, Emerging; Cyclosporins; Cytosine; Dengue; Drug Approval; Drug Design; Erlotinib Hydrochloride; Hemorrhagic Fever, Ebola; Humans; Imatinib Mesylate; Indoles; Organophosphonates; Piperazines; Purine Nucleosides; Pyrimidines; Pyrroles; Pyrrolidines; Quinazolines; Sunitinib; Viruses | 2015 |
Impaired airway epithelial barrier integrity was mediated by PI3Kδ in a mouse model of lipopolysaccharide-induced acute lung injury.
Topics: Acute Lung Injury; Adenine; Adenosine; Animals; Bronchoalveolar Lavage Fluid; Cadherins; Class I Phosphatidylinositol 3-Kinases; Claudins; Cytokines; Disease Models, Animal; Lipopolysaccharides; Lung; Male; Mice, Inbred BALB C; Quinazolines; Quinolines | 2021 |